Structure information

FFA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8T3V

SPECIES

Homo sapiens

RESOLUTION

3.390

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADJ2384

PUBLICATION DATE

Jan. 24, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid A83 3.29x29 TM3 hydrophobic
docosahexaenoic acid V84 3.30x30 TM3 hydrophobic
docosahexaenoic acid F87 3.33x33 TM3 hydrophobic
docosahexaenoic acid L135 4.54x54 TM4 hydrophobic
docosahexaenoic acid L138 4.57x57 TM4 hydrophobic
docosahexaenoic acid F142 4.61x61 TM4 hydrophobic
docosahexaenoic acid R183 5.39x40 TM5 polar (charge-assisted hydrogen bond)
docosahexaenoic acid Y240 6.51x51 TM6 polar (hydrogen bond)
docosahexaenoic acid Y240 6.51x51 TM6 Van der Waals
docosahexaenoic acid R258 7.35x34 TM7 polar (charge-assisted hydrogen bond)

Ligands

docosahexaenoic acid

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Residue Diagrams

V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7
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ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM3
3x29 3.29x29 A83
3x30 3.30x30 V84
3x33 3.33x33 F87
TM4
4x54 4.54x54 L135
4x57 4.57x57 L138
4x61 4.61x61 F142
TM5
5x40 5.39x40 R183
TM6
6x51 6.51x51 Y240
TM7
7x34 7.35x34 R258