PDB
8TAO
Resolution
2.9 Å
Released
Oct. 11, 2023
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligands
Nanobody 43
quisqualate
CDPPB
Function
PAM
Agonist
Ago-PAM
Reference
10.1101/2023.08.29.555158
Nanobody 43 quisqualate CDPPB

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Ligand Amino Acid Generic Number Segment Interaction Type
Nanobody 43 R25 N-term polar (hydrogen bond with backbone)
Nanobody 43 R25 N-term Van der Waals
Nanobody 43 V27 N-term Van der Waals
quisqualate Y64 N-term Van der Waals
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate W100 N-term aromatic (edge-to-face)
quisqualate W100 N-term Van der Waals
quisqualate G150 N-term Van der Waals
quisqualate S151 N-term Van der Waals
quisqualate S152 N-term polar (hydrogen bond)
quisqualate S152 N-term Van der Waals
quisqualate S173 N-term polar (hydrogen bond)
quisqualate S173 N-term polar (hydrogen bond with backbone)
quisqualate S173 N-term Van der Waals
quisqualate A174 N-term Van der Waals
quisqualate T175 N-term polar (hydrogen bond)
quisqualate Y223 N-term Van der Waals
quisqualate Y223 N-term hydrophobic
quisqualate E279 N-term Van der Waals
quisqualate D305 N-term polar (charge-assisted hydrogen bond)
quisqualate G306 N-term Van der Waals
quisqualate R310 N-term Van der Waals
Nanobody 43 H350 N-term polar (hydrogen bond)
Nanobody 43 H350 N-term Van der Waals
Nanobody 43 R351 N-term Van der Waals
Nanobody 43 N352 N-term Van der Waals
Nanobody 43 P353 N-term Van der Waals
Nanobody 43 P353 N-term hydrophobic
Nanobody 43 Q356 N-term Van der Waals
Nanobody 43 E368 N-term Van der Waals
Nanobody 43 G369 N-term polar (hydrogen bond with backbone)
Nanobody 43 G369 N-term Van der Waals
Nanobody 43 F370 N-term hydrophobic
Nanobody 43 F370 N-term Van der Waals
Nanobody 43 P371 N-term Van der Waals
Nanobody 43 P371 N-term polar (hydrogen bond with backbone)
Nanobody 43 Q372 N-term polar (hydrogen bond)
Nanobody 43 Q372 N-term Van der Waals
Nanobody 43 E373 N-term polar (charge-assisted hydrogen bond)
Nanobody 43 S375 N-term Van der Waals
quisqualate K396 N-term Van der Waals
CDPPB P655 3.40x40 TM3 hydrophobic
CDPPB Y659 3.44x44 TM3 hydrophobic
CDPPB L744 5.44x44 TM5 hydrophobic
CDPPB W785 6.50x50 TM6 hydrophobic
CDPPB V806 7.36x37 TM7 hydrophobic
CDPPB A810 7.40x41 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM3
3x36 3.40x40 P655
3x40 3.44x44 Y659
TM5
5x44 5.44x44 L744
TM6
6x48 6.50x50 W785
TM7
7x42 7.36x37 V806
7x46 7.40x41 A810