Structure information

CCR8

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8U1U

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 20, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CCL1 I116 N-term Van der Waals
CCL1 I116 N-term polar (hydrogen bond with backbone)
CCL1 C117 N-term polar (hydrogen bond)
CCL1 C117 N-term polar (hydrogen bond)
CCL1 C117 N-term polar (hydrogen bond with backbone)
CCL1 S118 N-term polar (hydrogen bond)
CCL1 S118 N-term polar (hydrogen bond with backbone)
CCL1 S119 N-term Van der Waals
CCL1 S119 N-term polar (hydrogen bond with backbone)
CCL1 P120 N-term Van der Waals
CCL1 P120 N-term hydrophobic
CCL1 C121 N-term Van der Waals
CCL1 C121 N-term polar (hydrogen bond with backbone)
CCL1 D122 N-term polar (charge-assisted hydrogen bond)
CCL1 A123 N-term polar (hydrogen bond with backbone)
CCL1 A123 N-term Van der Waals
CCL1 E124 N-term Van der Waals
CCL1 Q187 2.60x60 TM2 polar (hydrogen bond)
CCL1 Q187 2.60x60 TM2 polar (hydrogen bond)
CCL1 Q187 2.60x60 TM2 polar (hydrogen bond)
CCL1 Y190 2.63x63 TM2 polar (hydrogen bond with backbone)
CCL1 Y190 2.63x63 TM2 Van der Waals
CCL1 L191 2.64x64 TM2 Van der Waals
CCL1 L191 2.64x64 TM2 hydrophobic
CCL1 D193 2.66x66 TM2 Van der Waals
CCL1 Q194 23.49x49 ECL1 Van der Waals
CCL1 W195 23.50x50 ECL1 Van der Waals
CCL1 Y209 3.32x32 TM3 Van der Waals
CCL1 Y209 3.32x32 TM3 hydrophobic
CCL1 Y210 3.33x33 TM3 Van der Waals
CCL1 Y210 3.33x33 TM3 polar (hydrogen bond)
CCL1 Y268 4.64x65 TM4 polar (hydrogen bond)
CCL1 Y268 4.64x65 TM4 Van der Waals
CCL1 D274 ECL2 polar (charge-assisted hydrogen bond)
CCL1 V276 ECL2 hydrophobic
CCL1 V276 ECL2 Van der Waals
CCL1 Q278 ECL2 polar (hydrogen bond)
CCL1 Q278 ECL2 polar (hydrogen bond)
CCL1 C279 45.50x50 ECL2 Van der Waals
CCL1 Y280 45.51x51 ECL2 hydrophobic
CCL1 Y280 45.51x51 ECL2 Van der Waals
CCL1 F282 ECL2 Van der Waals
CCL1 T287 5.31x32 TM5 polar (hydrogen bond)
CCL1 L288 5.32x33 TM5 hydrophobic
CCL1 L288 5.32x33 TM5 Van der Waals
CCL1 L354 6.55x55 TM6 Van der Waals
CCL1 H360 6.61x61 TM6 Van der Waals
CCL1 S361 6.62x62 TM6 polar (hydrogen bond with backbone)
CCL1 S361 6.62x62 TM6 Van der Waals
CCL1 H363 6.64x64 TM6 polar (hydrogen bond)
CCL1 H363 6.64x64 TM6 Van der Waals
CCL1 D366 ECL3 Van der Waals
CCL1 G367 7.24x23 TM7 Van der Waals
CCL1 C368 7.25x24 TM7 hydrophobic
CCL1 C368 7.25x24 TM7 Van der Waals
CCL1 S371 7.28x27 TM7 Van der Waals
CCL1 T375 7.32x31 TM7 Van der Waals
CCL1 T378 7.35x34 TM7 Van der Waals
CCL1 H379 7.36x35 TM7 Van der Waals
CCL1 E382 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CCL1

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Residue Diagrams

S N G L L S F V F L L C Y F V A L L L K 1 L N L A L S D L L F V F S F P F Q T Y Y 2 L T I F F M S S Y F G I Y Y F G S V V K 3 G T T L C L A V W L T A I M A T I P L 4 Y C F M F I T F P I L L G L I N M K F N T 5 L I V V I A S L L F W V P F N V V L F L 6 V P N V C C H T F S I I E T V H T A Y 7
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ICL1 K K L R ICL1ECL1 Q W V F ECL1ICL2 A V Y A L K V R ICL2ECL2 Q V A S E D G V L Q C Y S F Y N Q Q ECL2ICL3 Q N ICL3ECL3 L D ECL3N-term M D Y T L D L S V T T V T D Y Y Y P D I F S S P C D A E L I N-termC-term S C S Q I F N Y L G R Q M P R E S C E K S S S C Q Q H S S R S S S V D Y I L C-term Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H T I R M G T T L C L A V W L T A I M A T I P L L V F Y T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K L S E F K K H I F Q K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR8
TM2
2x60 2.60x60 Q91
2x63 2.63x63 Y94
2x64 2.64x64 L95
2x66 2.66x66 D97
ECL1
23x49 23.49x49 Q98
23x50 23.50x50 W99
TM3
3x32 3.32x32 Y113
3x33 3.33x33 Y114
TM4
4x65 4.64x65 Y172
ECL2
45x50 45.50x50 C183
45x51 45.51x51 Y184
TM5
5x32 5.31x32 T191
5x33 5.32x33 L192
TM6
6x55 6.55x55 L258
6x61 6.61x61 H264
6x62 6.62x62 S265
6x64 6.64x64 H267
TM7
7x23 7.24x23 G271
7x24 7.25x24 C272
7x27 7.28x27 S275
7x31 7.32x31 T279
7x34 7.35x34 T282
7x35 7.36x35 H283
7x38 7.39x38 E286