Structure information

NK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8U26

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

R

REFERENCE

10.1038/S41592-023-02082-9

PUBLICATION DATE

Nov. 15, 2023

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
substance P Q24 N-term polar (hydrogen bond)
substance P F25 N-term polar (hydrogen bond)
substance P N85 2.57x57 TM2 polar (hydrogen bond)
substance P N85 2.57x57 TM2 polar (hydrogen bond)
substance P N89 2.61x61 TM2 polar (hydrogen bond)
substance P N89 2.61x61 TM2 Van der Waals
substance P Y92 2.64x64 TM2 polar (hydrogen bond)
substance P A93 2.65x65 TM2 Van der Waals
substance P N96 2.68x68 TM2 polar (hydrogen bond)
substance P N96 2.68x68 TM2 polar (hydrogen bond)
substance P H108 3.28x28 TM3 Van der Waals
substance P N109 3.29x29 TM3 polar (hydrogen bond)
substance P I113 3.33x33 TM3 Van der Waals
substance P Q165 4.60x61 TM4 polar (hydrogen bond)
substance P E172 ECL2 polar (charge-charge)
substance P M174 ECL2 polar (charge-assisted hydrogen bond)
substance P M174 ECL2 polar (hydrogen bond)
substance P R177 ECL2 polar (charge-assisted hydrogen bond)
substance P V179 ECL2 hydrophobic
substance P V179 ECL2 Van der Waals
substance P C180 45.50x50 ECL2 Van der Waals
substance P C180 45.50x50 ECL2 polar (hydrogen bond with backbone)
substance P M181 45.51x51 ECL2 polar (hydrogen bond)
substance P H197 5.39x40 TM5 Van der Waals
substance P F264 6.51x51 TM6 Van der Waals
substance P F264 6.51x51 TM6 hydrophobic
substance P F267 6.54x54 TM6 Van der Waals
substance P F268 6.55x55 TM6 polar (hydrogen bond)
substance P Y278 ECL3 polar (hydrogen bond with backbone)
substance P Y278 ECL3 Van der Waals
substance P L279 ECL3 polar (hydrogen bond)
substance P I283 7.31x30 TM7 hydrophobic
substance P I283 7.31x30 TM7 Van der Waals
substance P Q284 7.32x31 TM7 Van der Waals
substance P Y287 7.35x34 TM7 aromatic (face-to-edge)
substance P Y287 7.35x34 TM7 polar (hydrogen bond)
substance P Y287 7.35x34 TM7 polar (hydrogen bond)
substance P M291 7.39x38 TM7 polar (hydrogen bond)

Ligands

substance P

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

V N G V V S T V V I V T Y A A A W L V I 1 V N L A F A E A S M A A F N T V V N F T 2 A T M S Y I S A F V A A I P F F N H F K 3 T K V V I C V I W V L A L L L A F P Q 4 Y A Y G I V L L P L F Y I L V T V C I H Y 5 I V V V C T F A I C W L P F H I F F L L 6 I P N Y M T S S M A L W M I A L Y V Q 7
Download: PNG | SVG
ICL1 K R M R ICL1ECL1 E W Y Y ECL1ICL2 P L Q P R L ICL2ECL2 T T E T M P S R V V C M I E W P E H ECL2ICL3 S S D ICL3ECL3 P D L Y L K ECL3N-term M D N V L P V D S D L S P N I S T N T S E P N Q F V Q N-termC-term R C C P F I S A G D Y E G L E M K S T R Y L Q T Q G S V Y K V S R L E T T I S T V V G A H E E E P E D G P K A T P S S L D L T S N C S S R S D S K T M T E S F S F S S N V L S C-term P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A S E I P G D R Y H E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F K H F R L G A F
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
NK1 receptor
TM2
2x57 2.57x57 N85
2x61 2.61x61 N89
2x64 2.64x64 Y92
2x65 2.65x65 A93
2x68 2.68x68 N96
TM3
3x28 3.28x28 H108
3x29 3.29x29 N109
3x33 3.33x33 I113
TM4
4x61 4.60x61 Q165
ECL2
45x50 45.50x50 C180
45x51 45.51x51 M181
TM5
5x40 5.39x40 H197
TM6
6x51 6.51x51 F264
6x54 6.54x54 F267
6x55 6.55x55 F268
TM7
7x30 7.31x30 I283
7x31 7.32x31 Q284
7x34 7.35x34 Y287
7x38 7.39x38 M291