PDB
8WCA
Resolution
3.5 Å
Released
Dec. 27, 2023
Receptor
TA1
Class
A
Species
Homo sapiens
Ligand
Function
β-phenylethylamine
Agonist
Reference
10.1016/J.CELL.2023.10.014

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Ligand Amino Acid Generic Number Segment Interaction Type
β-phenylethylamine D103 3.32x32 TM3 polar (hydrogen bond)
β-phenylethylamine D103 3.32x32 TM3 polar (charge-charge)
β-phenylethylamine I104 3.33x33 TM3 hydrophobic
β-phenylethylamine S107 3.36x36 TM3 Van der Waals
β-phenylethylamine F186 ECL2 hydrophobic
β-phenylethylamine T194 5.42x43 TM5 hydrophobic
β-phenylethylamine W264 6.48x48 TM6 Van der Waals
β-phenylethylamine F267 6.51x51 TM6 hydrophobic
β-phenylethylamine F268 6.52x52 TM6 hydrophobic
β-phenylethylamine F268 6.52x52 TM6 aromatic (edge-to-face)
β-phenylethylamine I290 7.39x38 TM7 Van der Waals
β-phenylethylamine Y294 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
Helix box plot — Download: PNG | SVG L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 T194
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290
7x42 7.43x42 Y294