PDB
8WMA
Resolution
3.5 Å
Released
Sept. 11, 2024
Receptor
FZD4
Class
F
Species
Homo sapiens
Ligand
DEP domain of DVL2
Function
Allosteric agonist
Reference
10.1038/S41467-024-52174-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
DEP domain of DVL2 L333 ICL2 polar (hydrogen bond with backbone)
DEP domain of DVL2 L333 ICL2 Van der Waals
DEP domain of DVL2 K334 ICL2 polar (hydrogen bond with backbone)
DEP domain of DVL2 K334 ICL2 Van der Waals
DEP domain of DVL2 W335 ICL2 polar (hydrogen bond with backbone)
DEP domain of DVL2 W335 ICL2 Van der Waals
DEP domain of DVL2 G336 ICL2 Van der Waals
DEP domain of DVL2 H337 ICL2 polar (hydrogen bond with backbone)
DEP domain of DVL2 H337 ICL2 polar (hydrogen bond)
DEP domain of DVL2 H337 ICL2 Van der Waals
DEP domain of DVL2 E338 4.36x36 TM4 polar (charge-assisted hydrogen bond)
DEP domain of DVL2 A339 4.37x37 TM4 Van der Waals
DEP domain of DVL2 K429 6.25x25 TM6 polar (charge-assisted hydrogen bond)

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ICL1 S S R F S ICL1ECL1 R E R I S C D F E E A A E P V L I Q E G L K ECL1ICL2 L K W ICL2ECL2 L V D A D E L T G L C Y V G N Q ECL2ICL3 Q K D G T K T D K L ICL3ECL3 W A L F R Y S A D D S ECL3N-term M A W R G A G P S V P G A P G G V G L S L G L L L Q L L L L L G P A R G F G D E E E R R C D P I R I S M C Q N L G Y N V T K M P N L V G H E L Q T D A E L Q L T T F T P L I Q Y G C S S Q L Q F F L C S V Y V P M C T E K I N I P I G P C G G M C L S V K R R C E P V L K E F G F A W P E S L N C S K F P P Q N D H N H M C M E G P G D E E V P L P H K T P I Q P G E E C H S V G T N S D Q Y I W V K R S L N C V L K C G Y D A G L Y N-termC-term N S G K V K R E K R G N G W V K P G K G S E T V V C-term S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G N T G C A I I F L L M Y F F G M A S S I W W V I L T L T W F L A A G G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N L E R L M V K I G V F S V L Y T V P A T C V I A C Y F Y E I S N N M A V E M L K I F M S L L V G I T S G M W I W S A K W Q K L V T L H T C S N R
Helix box plot — Download: PNG | SVG A T S I F C L S A W V A M W I D T F E K 1 I F L S M C Y N I Y S I A Y I V R L T V 2 I V W W I S S A M G F F Y M L L F I I A 3 S S Y F H I A A W A I P A V K T I V I L 4 I F L T G I V L Y T F L P A V V F G T L A 5 G V F S V L Y T V P A T C V I A C Y F Y 6 M G S T I G V L L S M F I K L M E V A M 7

GPCRdb(A)
GPCRdb(F)
FZD4
TM4
4x36 4.36x36 E338
4x37 4.37x37 A339