PDB
9B9Y
Resolution
3.5 Å
Released
Nov. 20, 2024
Receptor
CB1
Class
A
Species
Homo sapiens
Ligand
taranabant
Function
Inverse agonist
Reference
10.1038/S41467-024-54206-0

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
taranabant F102 N-term hydrophobic
taranabant M103 N-term hydrophobic
taranabant F108 N-term hydrophobic
taranabant G166 2.53x53 TM2 Van der Waals
taranabant G166 2.53x53 TM2 polar (hydrogen bond with backbone)
taranabant F170 2.57x57 TM2 Van der Waals
taranabant F170 2.57x57 TM2 aromatic (edge-to-face)
taranabant V196 3.32x32 TM3 hydrophobic
taranabant V196 3.32x32 TM3 Van der Waals
taranabant F268 ECL2 Van der Waals
taranabant F268 ECL2 hydrophobic
taranabant L359 6.51x51 TM6 hydrophobic
taranabant L359 6.51x51 TM6 Van der Waals
taranabant F379 7.35x34 TM7 Van der Waals
taranabant A380 7.36x35 TM7 Van der Waals
taranabant S383 7.39x38 TM7 polar (hydrogen bond)
taranabant M384 7.40x39 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x53 2.53x53 G166
2x57 2.57x57 F170
TM3
3x32 3.32x32 V196
TM6
6x51 6.51x51 L359
TM7
7x34 7.35x34 F379
7x35 7.36x35 A380
7x38 7.39x38 S383
7x39 7.40x39 M384