PDB
9GG5
Resolution
3.3 Å
Released
Aug. 27, 2025
Receptor
TP
Class
A
Species
Homo sapiens
Ligands
Cholesterol
U46619
Function
PAM
Agonist
Reference
10.1038/S41467-026-69844-9
Cholesterol U46619

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol F30 1.38x38 TM1 hydrophobic
U46619 A31 1.39x39 TM1 hydrophobic
U46619 L78 2.54x54 TM2 hydrophobic
U46619 V85 2.61x61 TM2 hydrophobic
U46619 H89 2.65x65 TM2 Van der Waals
U46619 H89 2.65x65 TM2 polar (hydrogen bond)
U46619 M112 3.32x32 TM3 Van der Waals
U46619 M112 3.32x32 TM3 hydrophobic
U46619 G116 3.36x36 TM3 Van der Waals
U46619 P179 ECL2 Van der Waals
U46619 S181 ECL2 Van der Waals
U46619 W182 ECL2 Van der Waals
U46619 W182 ECL2 hydrophobic
U46619 F184 45.51x51 ECL2 Van der Waals
U46619 W258 6.48x48 TM6 hydrophobic
U46619 W258 6.48x48 TM6 Van der Waals
Cholesterol I292 7.37x36 TM7 hydrophobic
U46619 R295 7.40x39 TM7 Van der Waals
Cholesterol V296 7.41x40 TM7 hydrophobic
U46619 T298 7.43x42 TM7 Van der Waals
Cholesterol W299 7.44x43 TM7 hydrophobic
U46619 Q301 7.46x46 TM7 Van der Waals
U46619 Q301 7.46x46 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 G G S H T R ICL1ECL1 L F E W H A V D P G ECL1ICL2 P F S R P A V A ICL2ECL2 V G R Y T V Q Y P G S W C F L T L G A ECL2ICL3 E A A Q ICL3ECL3 N P P A M S P A G Q L ECL3N-term M W P N G S S L G P C F R P T N I T L E E R R L I A N-termC-term L Q P Q L T Q R S G L Q C-term S P W F A A S F C V V G L A S N L L A L S V L A G A R Q S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R S Q R R A W A T V G L V W A A A L A L G L L P L L G E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A L Q P R P R V L R R R L S T S L S
Helix box plot — Download: PNG | SVG L N S A L G V V C F S A A F W P S 1 C G L V L T D F L G L L V T G T I V V S 2 A A G L L L P S L G F F I M V V G M F R 3 A W A T V G L V W A A A L A L G L L P L 4 N L L F S L G V S L G G L M S F L L G F 5 L G I M V V A S V C W L P L L V F I A Q 6 W P D L I Q N W T A V R L Y I L L E K 7

GPCRdb(A)
GPCRdb(A)
TP receptor
TM1
1x38 1.38x38 F30
1x39 1.39x39 A31
TM2
2x54 2.54x54 L78
2x61 2.61x61 V85
2x65 2.65x65 H89
TM3
3x32 3.32x32 M112
3x36 3.36x36 G116
ECL2
45x51 45.51x51 F184
TM6
6x48 6.48x48 W258
TM7
7x36 7.37x36 I292
7x39 7.40x39 R295
7x40 7.41x40 V296
7x42 7.43x42 T298
7x43 7.44x43 W299
7x46 7.46x46 Q301