PDB
9IQR
Resolution
3.4 Å
Released
July 23, 2025
Receptor
α2A
Class
A
Species
Homo sapiens
Ligand
muscarinic toxin 3
Function
Antagonist
Reference
10.1038/S41467-025-61695-0

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Ligand Amino Acid Generic Number Segment Interaction Type
muscarinic toxin 3 Y124 3.28x28 TM3 hydrophobic
muscarinic toxin 3 L125 3.29x29 TM3 hydrophobic
muscarinic toxin 3 D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
muscarinic toxin 3 E200 ECL2 Van der Waals
muscarinic toxin 3 R202 ECL2 Van der Waals
muscarinic toxin 3 C203 45.50x50 ECL2 Van der Waals
muscarinic toxin 3 E204 45.51x51 ECL2 Van der Waals
muscarinic toxin 3 K209 ECL2 Van der Waals
muscarinic toxin 3 I213 5.40x41 TM5 hydrophobic
muscarinic toxin 3 I213 5.40x41 TM5 Van der Waals
muscarinic toxin 3 F405 6.51x51 TM6 Van der Waals
muscarinic toxin 3 F405 6.51x51 TM6 hydrophobic
muscarinic toxin 3 Y409 6.55x55 TM6 polar (hydrogen bond)
muscarinic toxin 3 Y409 6.55x55 TM6 Van der Waals
muscarinic toxin 3 T412 6.58x58 TM6 Van der Waals
muscarinic toxin 3 A413 6.59x59 TM6 polar (hydrogen bond with backbone)
muscarinic toxin 3 A413 6.59x59 TM6 Van der Waals
muscarinic toxin 3 V414 6.60x60 TM6 polar (hydrogen bond with backbone)
muscarinic toxin 3 V414 6.60x60 TM6 Van der Waals
muscarinic toxin 3 G415 6.61x61 TM6 Van der Waals
muscarinic toxin 3 G415 6.61x61 TM6 polar (hydrogen bond with backbone)
muscarinic toxin 3 V418 ECL3 Van der Waals
muscarinic toxin 3 R420 7.32x31 TM7 polar (charge-assisted hydrogen bond)
muscarinic toxin 3 F423 7.35x34 TM7 hydrophobic
muscarinic toxin 3 F423 7.35x34 TM7 Van der Waals
muscarinic toxin 3 K424 7.36x35 TM7 Van der Waals
muscarinic toxin 3 F427 7.39x38 TM7 hydrophobic
muscarinic toxin 3 F427 7.39x38 TM7 Van der Waals

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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Helix box plot — Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7

GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x28 3.28x28 Y124
3x29 3.29x29 L125
3x32 3.32x32 D128
ECL2
45x50 45.50x50 C203
45x51 45.51x51 E204
TM5
5x41 5.40x41 I213
TM6
6x51 6.51x51 F405
6x55 6.55x55 Y409
6x58 6.58x58 T412
6x59 6.59x59 A413
6x60 6.60x60 V414
6x61 6.61x61 G415
TM7
7x31 7.32x31 R420
7x34 7.35x34 F423
7x35 7.36x35 K424
7x38 7.39x38 F427