Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

9IVG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.APSB.2024.09.002

PUBLICATION DATE

Nov. 27, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL410972 S31 N-term polar (hydrogen bond)
CHEMBL410972 L32 N-term Van der Waals
CHEMBL410972 L32 N-term polar (hydrogen bond with backbone)
CHEMBL410972 T35 N-term polar (hydrogen bond)
CHEMBL410972 D67 N-term polar (hydrogen bond with backbone)
CHEMBL410972 D67 N-term Van der Waals
CHEMBL410972 E68 N-term polar (charge-assisted hydrogen bond)
CHEMBL410972 Y69 N-term Van der Waals
CHEMBL410972 Y69 N-term hydrophobic
CHEMBL410972 L89 N-term hydrophobic
CHEMBL410972 L89 N-term Van der Waals
CHEMBL410972 P90 N-term Van der Waals
CHEMBL410972 W91 N-term Van der Waals
CHEMBL410972 L118 N-term hydrophobic
CHEMBL410972 L118 N-term Van der Waals
CHEMBL410972 L141 1.36x36 TM1 polar (hydrogen bond with backbone)
CHEMBL410972 L141 1.36x36 TM1 Van der Waals
CHEMBL410972 L142 1.37x37 TM1 Van der Waals
CHEMBL410972 Y145 1.40x40 TM1 Van der Waals
CHEMBL410972 Y145 1.40x40 TM1 hydrophobic
CHEMBL410972 Y148 1.43x43 TM1 Van der Waals
CHEMBL410972 D198 2.68x68 TM2 Van der Waals
CHEMBL410972 L201 2.71x71 TM2 hydrophobic
CHEMBL410972 L201 2.71x71 TM2 Van der Waals
CHEMBL410972 K202 2.72x72 TM2 Van der Waals
CHEMBL410972 Y205 2.75x75 TM2 hydrophobic
CHEMBL410972 Y205 2.75x75 TM2 Van der Waals
CHEMBL410972 A208 2.78x78 TM2 Van der Waals
CHEMBL410972 A208 2.78x78 TM2 polar (hydrogen bond with backbone)
CHEMBL410972 Q211 ECL1 polar (hydrogen bond)
CHEMBL410972 W214 ECL1 Van der Waals
CHEMBL410972 W214 ECL1 hydrophobic

Ligands

CHEMBL410972

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x33 1.37x37 L142
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x61 2.68x68 D198
2x64 2.71x71 L201
2x65 2.72x72 K202
2x68 2.75x75 Y205