PDB
9JH5
Resolution
2.8 Å
Released
April 23, 2025
Receptor
CysLT2
Class
A
Species
Homo sapiens
Ligand
C16:0 ceramide
Function
Agonist
Reference
10.1038/S41586-025-08792-8

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Ligand Amino Acid Generic Number Segment Interaction Type
C16:0 ceramide Y116 3.30x30 TM3 hydrophobic
C16:0 ceramide Y123 3.37x37 TM3 polar (hydrogen bond)
C16:0 ceramide Y127 3.41x41 TM3 Van der Waals
C16:0 ceramide Y127 3.41x41 TM3 hydrophobic
C16:0 ceramide I166 4.53x53 TM4 hydrophobic
C16:0 ceramide I166 4.53x53 TM4 Van der Waals
C16:0 ceramide S170 4.57x57 TM4 Van der Waals
C16:0 ceramide I195 ECL2 Van der Waals
C16:0 ceramide I195 ECL2 hydrophobic
C16:0 ceramide L198 5.35x36 TM5 Van der Waals
C16:0 ceramide N202 5.39x40 TM5 polar (hydrogen bond)
C16:0 ceramide N202 5.39x40 TM5 Van der Waals
C16:0 ceramide R267 6.55x55 TM6 polar (charge-assisted hydrogen bond)
C16:0 ceramide H270 6.58x58 TM6 Van der Waals
C16:0 ceramide L271 6.59x59 TM6 hydrophobic
C16:0 ceramide L271 6.59x59 TM6 Van der Waals
C16:0 ceramide K275 ECL3 Van der Waals

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ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
Helix box plot — Download: PNG | SVG G N G L V G W F F I I L Y V I P F F E R 1 L N L A I S D L L F I S T L P F R A D Y 2 V T L F Y I S S Y M N V Y L S Y S M I R 3 A W I L C G I I W I L I M A S S I M L 4 Y C I S L T F F P L L C G V V L A I Y N M 5 I I I T L I I F L F C F L P Y H T L R T V 6 L P N F C A N A A A L A L T I V L A K 7

GPCRdb(A)
GPCRdb(A)
CysLT2 receptor
TM3
3x30 3.30x30 Y116
3x37 3.37x37 Y123
3x41 3.41x41 Y127
TM4
4x53 4.53x53 I166
4x57 4.57x57 S170
TM5
5x36 5.35x36 L198
5x40 5.39x40 N202
TM6
6x55 6.55x55 R267
6x58 6.58x58 H270
6x59 6.59x59 L271