PDB
9JHJ
Resolution
3.2 Å
Released
March 19, 2025
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Function
C18 Ceramide
Agonist
Reference
10.1126/SCIENCE.ADO4188

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Ligand Amino Acid Generic Number Segment Interaction Type
C18 Ceramide L109 3.36x36 TM3 hydrophobic
C18 Ceramide F110 3.37x37 TM3 hydrophobic
C18 Ceramide T168 ECL2 Van der Waals
C18 Ceramide I169 ECL2 Van der Waals
C18 Ceramide P170 ECL2 Van der Waals
C18 Ceramide T177 45.51x51 ECL2 hydrophobic
C18 Ceramide F178 45.52x52 ECL2 Van der Waals
C18 Ceramide N179 ECL2 Van der Waals
C18 Ceramide R201 5.38x39 TM5 Van der Waals
C18 Ceramide R205 5.42x43 TM5 Van der Waals
C18 Ceramide F257 6.51x51 TM6 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM3
3x36 3.36x36 L109
3x37 3.37x37 F110
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x51 6.51x51 F257