PDB
9KZ2
Resolution
3.4 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
Function
EP67
Agonist
Reference
10.1073/PNAS.2614459123

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Ligand Amino Acid Generic Number Segment Interaction Type
EP67 F77 2.59x59 TM2 Van der Waals
EP67 S78 2.60x60 TM2 Van der Waals
EP67 H81 2.63x63 TM2 Van der Waals
EP67 P99 3.29x29 TM3 hydrophobic
EP67 I102 3.32x32 TM3 hydrophobic
EP67 V103 3.33x33 TM3 Van der Waals
EP67 M106 3.36x36 TM3 hydrophobic
EP67 V157 4.60x61 TM4 Van der Waals
EP67 F164 ECL2 hydrophobic
EP67 F164 ECL2 aromatic (edge-to-face)
EP67 R171 ECL2 Van der Waals
EP67 Y174 45.52x52 ECL2 Van der Waals
EP67 L333 5.35x36 TM5 hydrophobic
EP67 R340 5.42x43 TM5 polar (charge-charge)
EP67 R340 5.42x43 TM5 polar (hydrogen bond)
EP67 Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
EP67 F396 6.54x54 TM6 Van der Waals
EP67 G397 6.55x55 TM6 Van der Waals
EP67 M414 7.32x31 TM7 Van der Waals
EP67 D417 7.35x34 TM7 polar (charge-charge)
EP67 D417 7.35x34 TM7 polar (hydrogen bond)
EP67 H418 7.36x35 TM7 Van der Waals
EP67 I421 7.39x38 TM7 hydrophobic

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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x59 2.59x59 F77
2x60 2.60x60 S78
2x63 2.63x63 H81
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
3x33 3.33x33 V103
3x36 3.36x36 M106
TM4
4x61 4.60x61 V157
ECL2
45x52 45.52x52 Y174
TM5
5x36 5.35x36 L333
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x31 7.32x31 M414
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421