PDB
9LDV
Resolution
2.8 Å
Released
Jan. 28, 2026
Receptor
OR6C76
Class
O2
Species
Homo sapiens
Ligands
Cholesterol
ethyl (2R,3S)-3-methyl-3-phenyl-oxirane-2-carboxylate
Function
PAM
Agonist
Reference
—
Cholesterol ethyl (2R,3S)-3-methyl-3-phenyl-oxirane-2-carboxylate

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol W70 2.52x52 TM2 hydrophobic
Cholesterol V74 2.56x56 TM2 hydrophobic
Cholesterol F101 3.31x31 TM3 hydrophobic
ethyl (2R,3S)-3-methyl-3-phenyl-oxirane-2-carboxylate I103 3.33x33 TM3 hydrophobic
ethyl (2R,3S)-3-methyl-3-phenyl-oxirane-2-carboxylate L200 5.42x42 TM5 hydrophobic
ethyl (2R,3S)-3-methyl-3-phenyl-oxirane-2-carboxylate Y257 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S H L K ICL1ECL1 D K S I ECL1ICL2 P L H Y T T I M ICL2ECL2 Q L D F C D S N V I D H F T C D S A P L L Q I S C T D ECL2ICL3 I P ICL3ECL3 K T ECL3N-term M K N R T S V T D F I L L G L T D N-termC-term K H C-term N P Q L Q V V I F S F L F L T Y V L S V T G N L T I I S L T L L D T P M Y F F L R N F S L E I S F T S V C N P R F L I S I L T G S Y N A C A A Q L F F F I F L G S T E F F L L A S M S Y D C Y V A I C K S D R I C Y Q L I I S S W L A G F L V I F P P L A M G L T S T L E L M S F I L A L F T L I S T L I L V I L S Y T Y I I R T I L R S A Q Q R K K A F S T C S S H V I V V S I S Y G S C I F M Y V S A K E G V A L T K G V A I L N T S V A P M L N P F I Y T L R N Q Q F K D I S H V K Q A V L R K K K K
Helix box plot — Download: PNG | SVG L N G T V S L V Y T L F L F S F I V V Q 1 R N F S L E I S F T S V C N P R F L I 2 S A L L F F E T S G L F I F F F L Q A A 3 C Y Q L I I S S W L A G F L V I F P P L 4 Y S L I V L I L T S I L T F L A L I F S 5 S S H V I V V S I S Y G S C I F M Y V 6 F P N L M P A V S T N L I A V G K T L 7

GPCRdb(A)
GPCRdb(A)
OR6C76
TM2
2x52 2.52x52 S69
2x56 2.56x56 V73
TM3
3x31 3.31x31 F100
3x33 3.33x33 I102
TM5
5x42 5.42x42 L199
TM6
6x55 6.55x55 Y256