PDB
9LE0
Resolution
2.5 Å
Released
Jan. 28, 2026
Receptor
OR6A2
Class
O2
Species
Homo sapiens
Ligand
Octanal
Function
Agonist
Reference
10.1016/J.CELL.2025.12.017

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Ligand Amino Acid Generic Number Segment Interaction Type
Octanal F102 3.32x32 TM3 hydrophobic
Octanal L103 3.33x33 TM3 hydrophobic
Octanal L200 5.42x42 TM5 hydrophobic
Octanal A201 5.43x43 TM5 hydrophobic
Octanal I204 5.46x46 TM5 hydrophobic
Octanal F249 6.47x47 TM6 hydrophobic
Octanal Y257 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S T L H ICL1ECL1 K Q D H G Q L I ECL1ICL2 P L H Y P V I V ICL2ECL2 L S Y C G P N I I N H F F C D V S P L L N L S C T D ECL2ICL3 I P ICL3ECL3 R P K A L S A F ECL3N-term M E W R N H S G R V S E F V L L G F P A N-termC-term H L Y Q H Q D P D P K K A S R N V C-term P A P L Q V L L F A L L L L A Y V L V L T E N T L I I M A I R N H K P M Y F F L A N M S F L E I W Y V T V T I P K M L A G F V G S S F E G C M T Q L Y F F L G L G C T E C V L L A V M A Y D R Y M A I C Y S G R L C V Q M A A G S W A G G F G I S M V K V F L I S G M S T A E L T D F I L A I F I L L G P L S V T G A S Y V A I T G A V M H S A A G R Y K A F S T C A S H L T V V I I F Y A A S I F I Y A D T N K L V S V L Y A V I V P L L N P I I Y C L R N Q E L C C V K R A T L
Helix box plot — Download: PNG | SVG T N E T L V L V Y A L L L L A F L L V Q 1 A N M S F L E I W Y V T V T I P K M L A 2 V A L L V C E T C G L G L F F Y L Q T M 3 C V Q M A A G S W A G G F G I S M V K V 4 Y S A G T V S L P G L L I F I A L I F D 5 A S H L T V V I I F Y A A S I F I Y A 6 I P N L L P V I V A Y L V S V L K N T 7

GPCRdb(A)
GPCRdb(A)
OR6A2
TM3
3x32 3.32x32 F109
3x33 3.33x33 L110
TM5
5x42 5.42x42 L207
5x43 5.43x43 A208
5x46 5.46x46 I211
TM6
6x47 6.47x47 F256
6x55 6.55x55 Y264