PDB
9LW5
Resolution
2.9 Å
Released
Feb. 18, 2026
Receptor
β2
Class
A
Species
Homo sapiens
Ligand
dopamine
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dopamine V114 3.33x33 TM3 Van der Waals
dopamine V114 3.33x33 TM3 hydrophobic
dopamine S117 3.36x36 TM3 Van der Waals
dopamine S203 5.42x43 TM5 polar (hydrogen bond with backbone)
dopamine S203 5.42x43 TM5 polar (hydrogen bond)
dopamine S203 5.42x43 TM5 Van der Waals
dopamine S207 5.46x461 TM5 Van der Waals
dopamine S207 5.46x461 TM5 polar (hydrogen bond)
dopamine F289 6.51x51 TM6 aromatic (edge-to-face)
dopamine F289 6.51x51 TM6 Van der Waals
dopamine F290 6.52x52 TM6 Van der Waals
dopamine F290 6.52x52 TM6 hydrophobic
dopamine Y316 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
TM5
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x42 7.43x42 Y316