PDB
9MBA
Resolution
3.1 Å
Released
Oct. 1, 2025
Receptor
mGlu8
Class
C
Species
Homo sapiens
Ligand
L-glutamic acid
Function
Agonist
Reference
10.1016/J.MOLCEL.2025.08.019

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid K71 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid R75 N-term Van der Waals
L-glutamic acid A154 N-term polar (hydrogen bond with backbone)
L-glutamic acid A154 N-term Van der Waals
L-glutamic acid A155 N-term Van der Waals
L-glutamic acid S156 N-term polar (hydrogen bond)
L-glutamic acid S156 N-term polar (hydrogen bond with backbone)
L-glutamic acid S156 N-term Van der Waals
L-glutamic acid A177 N-term Van der Waals
L-glutamic acid A177 N-term polar (hydrogen bond with backbone)
L-glutamic acid S178 N-term Van der Waals
L-glutamic acid T179 N-term polar (hydrogen bond)
L-glutamic acid T179 N-term polar (hydrogen bond with backbone)
L-glutamic acid T179 N-term Van der Waals
L-glutamic acid Y227 N-term hydrophobic
L-glutamic acid Y227 N-term Van der Waals
L-glutamic acid D309 N-term Van der Waals
L-glutamic acid K401 N-term polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T N D P I V R A S ICL1ECL1 A P ECL1ICL2 G K K S V T A P K F I ICL2ECL2 P P H I I I D Y G E Q R T L D P E K A R G V L K C D I ECL2ICL3 G V P E T ICL3ECL3 A Q S A E K M Y ECL3N-term M V C E G K R S A S C P C F F L L T A K F Y W I L T M M Q R T H S Q E Y A H S I R V D G D I I L G G L F P V H A K G E R G V P C G E L K K E K G I H R L E A M L Y A I D Q I N K D P D L L S N I T L G V R I L D T C S R D T Y A L E Q S L T F V Q A L I E K D A S D V K C A N G D P P I F T K P D K I S G V I G A A A S S V S I M V A N I L R L F K I P Q I S Y A S T A P E L S D N T R Y D F F S R V V P P D S Y Q A Q A M V D I V T A L G W N Y V S T L A S E G N Y G E S G V E A F T Q I S R E I G G V C I A Q S Q K I P R E P R P G E F E K I I K R L L E T P N A R A V I M F A N E D D I R R I L E A A K K L N Q S G H F L W I G S D S W G S K I A P V Y Q Q E E I A E G A V T I L P K R A S I D G F D R Y F R S R T L A N N R R N V W F A E F W E E N F G C K L G S H G K R N S H I K K C T G L E R I A R D S S Y E Q E G K V Q F V I D A V Y S M A Y A L H N M H K D L C P G Y I G L C P R M S T I D G K E L L G Y I R A V N F N G S A G T P V T F N E N G D A P G R Y D I F Q Y Q I T N K S T E Y K V I G H W T N Q L H L K V E D M Q W A H R E H T H P A S V C S L P C K P G E R K K T V K G V P C C W H C E R C E G Y N Y Q V D E L S C E L C P L D Q R P N M N R T G C Q L I P I I K L E W H S P N-termC-term K A V V T A A T M Q S K L I Q K G N D R P N G E V K S E L C E S L E T N T S S T K T T Y I S Y S N H S I C-term W A V V P V F V A I L G I I A T T F V I V T F V R Y G R E L S Y V L L T G I F L C Y S I T F L M I A D T I I C S F R R V F L G L G M C F S Y A A L L T K T N R I H R I F E Q S P A S Q L V I T F S L I S V Q L L G V F V W F V V D S D L S L I C S L G Y S I L L M V T C T V Y A I K T R F N E A K P I G F T M Y T T C I I W L A F I P I F F G T I Q T T T L T V S M S L S A S V S L G M L Y M P K V Y I I I F H P E Q R K R N V Q K S F
Helix box plot — Download: PNG | SVG T T A I I G L I A V F V P V V A W 1 Y V L L T G I F L C Y S I T F L M I A 2 T L L A A Y S F C M G L G L F V R R F S 3 Q L V I T F S L I S V Q L L G V F V W F 4 A Y V T C T V M L L I S Y G L S C I L S 5 G F T M Y T T C I I W L A F I P I F F G 6 G L S V S A S L S M S V T L T T T Q I 7

GPCRdb(A)
GPCRdb(C)
mGlu8 receptor