PDB
9N04
Resolution
2.3 Å
Released
April 22, 2026
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Peptide 15
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 15 A26 N-term polar (hydrogen bond with backbone)
Peptide 15 A26 N-term Van der Waals
Peptide 15 Q27 N-term Van der Waals
Peptide 15 V28 N-term polar (hydrogen bond with backbone)
Peptide 15 V28 N-term Van der Waals
Peptide 15 M29 N-term polar (hydrogen bond with backbone)
Peptide 15 M29 N-term Van der Waals
Peptide 15 L32 N-term Van der Waals
Peptide 15 L32 N-term hydrophobic
Peptide 15 F33 N-term hydrophobic
Peptide 15 W36 N-term Van der Waals
Peptide 15 W36 N-term aromatic (face-to-edge)
Peptide 15 K64 N-term Van der Waals
Peptide 15 Y65 N-term Van der Waals
Peptide 15 Y65 N-term hydrophobic
Peptide 15 Y84 N-term Van der Waals
Peptide 15 W87 N-term hydrophobic
Peptide 15 R116 N-term polar (charge-assisted hydrogen bond)
Peptide 15 Q131 1.29x29 TM1 Van der Waals
Peptide 15 V134 1.32x32 TM1 Van der Waals
Peptide 15 A135 1.33x33 TM1 Van der Waals
Peptide 15 Y138 1.36x36 TM1 polar (hydrogen bond)
Peptide 15 Y138 1.36x36 TM1 polar (hydrogen bond)
Peptide 15 Y138 1.36x36 TM1 aromatic (edge-to-face)
Peptide 15 F141 1.39x39 TM1 Van der Waals
Peptide 15 F141 1.39x39 TM1 hydrophobic
Peptide 15 Q142 1.40x40 TM1 polar (hydrogen bond)
Peptide 15 Q142 1.40x40 TM1 Van der Waals
Peptide 15 Y145 1.43x43 TM1 aromatic (edge-to-face)
Peptide 15 Y145 1.43x43 TM1 Van der Waals
Peptide 15 Y149 1.47x47 TM1 Van der Waals
Peptide 15 Y149 1.47x47 TM1 polar (hydrogen bond)
Peptide 15 V191 2.64x64 TM2 hydrophobic
Peptide 15 V191 2.64x64 TM2 Van der Waals
Peptide 15 L198 2.71x71 TM2 Van der Waals
Peptide 15 Y202 2.75x75 TM2 hydrophobic
Peptide 15 Y202 2.75x75 TM2 Van der Waals
Peptide 15 I206 ECL1 Van der Waals
Peptide 15 I206 ECL1 hydrophobic
Peptide 15 G207 ECL1 Van der Waals
Peptide 15 D209 ECL1 Van der Waals
Peptide 15 V212 ECL1 Van der Waals
Peptide 15 V212 ECL1 hydrophobic
Peptide 15 M231 3.36x36 TM3 hydrophobic
Peptide 15 M231 3.36x36 TM3 Van der Waals
Peptide 15 Q232 3.37x37 TM3 polar (hydrogen bond)
Peptide 15 I235 3.40x40 TM3 Van der Waals
Peptide 15 I235 3.40x40 TM3 hydrophobic
Peptide 15 Y239 3.44x44 TM3 Van der Waals
Peptide 15 Q293 ECL2 Van der Waals
Peptide 15 T296 45.52x52 ECL2 Van der Waals
Peptide 15 T296 45.52x52 ECL2 polar (hydrogen bond)
Peptide 15 S297 ECL2 Van der Waals
Peptide 15 N298 ECL2 Van der Waals
Peptide 15 N298 ECL2 polar (hydrogen bond with backbone)
Peptide 15 W304 5.36x37 TM5 aromatic (edge-to-face)
Peptide 15 W304 5.36x37 TM5 Van der Waals
Peptide 15 R308 5.40x40 TM5 Van der Waals
Peptide 15 D370 ECL3 Van der Waals
Peptide 15 R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide 15 K381 7.38x37 TM7 Van der Waals
Peptide 15 L382 7.39x38 TM7 hydrophobic
Peptide 15 L382 7.39x38 TM7 Van der Waals
Peptide 15 D385 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Peptide 15 L386 7.43x42 TM7 hydrophobic
Peptide 15 L386 7.43x42 TM7 Van der Waals

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x28 1.32x32 V134
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x64 2.71x71 L198
2x68 2.75x75 Y202
TM3
3x32 3.36x36 M231
3x33 3.37x37 Q232
3x36 3.40x40 I235
3x40 3.44x44 Y239
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x44 5.40x40 R308
TM7
7x30 7.35x34 R378
7x33 7.38x37 K381
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386