PDB
9N2I
Resolution
3.0 Å
Released
April 22, 2026
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
SRB103Q
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
SRB103Q A26 N-term Van der Waals
SRB103Q A26 N-term polar (hydrogen bond with backbone)
SRB103Q Q27 N-term Van der Waals
SRB103Q V28 N-term Van der Waals
SRB103Q V28 N-term polar (hydrogen bond with backbone)
SRB103Q M29 N-term Van der Waals
SRB103Q M29 N-term polar (hydrogen bond with backbone)
SRB103Q L32 N-term hydrophobic
SRB103Q L32 N-term Van der Waals
SRB103Q W36 N-term hydrophobic
SRB103Q W36 N-term Van der Waals
SRB103Q K64 N-term Van der Waals
SRB103Q Y65 N-term Van der Waals
SRB103Q Y65 N-term hydrophobic
SRB103Q L85 N-term Van der Waals
SRB103Q L85 N-term hydrophobic
SRB103Q W87 N-term Van der Waals
SRB103Q W87 N-term hydrophobic
SRB103Q R116 N-term Van der Waals
SRB103Q M123 N-term Van der Waals
SRB103Q Q131 1.29x29 TM1 polar (hydrogen bond)
SRB103Q Q131 1.29x29 TM1 polar (hydrogen bond)
SRB103Q A135 1.33x33 TM1 Van der Waals
SRB103Q Y138 1.36x36 TM1 hydrophobic
SRB103Q Y138 1.36x36 TM1 Van der Waals
SRB103Q F141 1.39x39 TM1 Van der Waals
SRB103Q F141 1.39x39 TM1 hydrophobic
SRB103Q Y145 1.43x43 TM1 hydrophobic
SRB103Q Y145 1.43x43 TM1 Van der Waals
SRB103Q Y149 1.47x47 TM1 Van der Waals
SRB103Q Y149 1.47x47 TM1 polar (hydrogen bond)
SRB103Q V191 2.64x64 TM2 Van der Waals
SRB103Q V191 2.64x64 TM2 hydrophobic
SRB103Q L198 2.71x71 TM2 Van der Waals
SRB103Q Y202 2.75x75 TM2 polar (hydrogen bond with backbone)
SRB103Q Y202 2.75x75 TM2 Van der Waals
SRB103Q Q204 ECL1 Van der Waals
SRB103Q Q204 ECL1 polar (hydrogen bond with backbone)
SRB103Q I206 ECL1 Van der Waals
SRB103Q I206 ECL1 hydrophobic
SRB103Q G207 ECL1 Van der Waals
SRB103Q D208 ECL1 Van der Waals
SRB103Q W215 ECL1 Van der Waals
SRB103Q W215 ECL1 hydrophobic
SRB103Q M231 3.36x36 TM3 hydrophobic
SRB103Q M231 3.36x36 TM3 Van der Waals
SRB103Q I235 3.40x40 TM3 Van der Waals
SRB103Q I235 3.40x40 TM3 hydrophobic
SRB103Q Q293 ECL2 Van der Waals
SRB103Q Q293 ECL2 polar (hydrogen bond)
SRB103Q T296 45.52x52 ECL2 polar (hydrogen bond)
SRB103Q S297 ECL2 Van der Waals
SRB103Q N298 ECL2 Van der Waals
SRB103Q W304 5.36x37 TM5 Van der Waals
SRB103Q W304 5.36x37 TM5 hydrophobic
SRB103Q L307 5.39x39 TM5 Van der Waals
SRB103Q D370 ECL3 polar (charge-assisted hydrogen bond)
SRB103Q R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
SRB103Q L382 7.39x38 TM7 hydrophobic
SRB103Q L382 7.39x38 TM7 Van der Waals
SRB103Q D385 7.42x41 TM7 Van der Waals
SRB103Q L386 7.43x42 TM7 hydrophobic
SRB103Q L386 7.43x42 TM7 Van der Waals

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x64 2.71x71 L198
2x68 2.75x75 Y202
TM3
3x32 3.36x36 M231
3x36 3.40x40 I235
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x43 5.39x39 L307
TM7
7x30 7.35x34 R378
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386