PDB
9OXB
Resolution
3.0 Å
Released
April 22, 2026
Receptor
TAS2R43
Class
T2
Species
Homo sapiens
Ligand
aristolochic acid
Function
Agonist
Reference
10.1038/S41594-026-01776-W

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Ligand Amino Acid Generic Number Segment Interaction Type
aristolochic acid N65 2.60x60 TM2 Van der Waals
aristolochic acid N65 2.60x60 TM2 polar (hydrogen bond)
aristolochic acid A84 3.28x28 TM3 hydrophobic
aristolochic acid A84 3.28x28 TM3 Van der Waals
aristolochic acid Y85 3.29x29 TM3 Van der Waals
aristolochic acid Y85 3.29x29 TM3 hydrophobic
aristolochic acid W88 3.32x32 TM3 Van der Waals
aristolochic acid W88 3.32x32 TM3 aromatic (face-to-face)
aristolochic acid N176 5.39x40 TM5 Van der Waals
aristolochic acid T180 5.43x44 TM5 Van der Waals
aristolochic acid S248 6.55x55 TM6 polar (charge-assisted hydrogen bond)
aristolochic acid V249 6.56x56 TM6 Van der Waals
aristolochic acid V249 6.56x56 TM6 hydrophobic
aristolochic acid F252 6.59x59 TM6 aromatic (face-to-face)
aristolochic acid F252 6.59x59 TM6 Van der Waals
aristolochic acid R268 7.42x41 TM7 polar (charge-assisted hydrogen bond)
aristolochic acid R268 7.42x41 TM7 polar (charge-charge)

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ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N F I F L H L K R ICL2ECL2 V R T K E F E G N M T W K I K L K S A M Y F S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K T S S P C-term I T F L P I I F S S L V V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L L L N W Y S T V L N S V E V R T T A Y N I W A V I N H F S N W L A T T L S I F Y L L K I A R V K S V I L V M L L G P L L F L A C H L F V I N M N E I N M T V T M V A N L V P F T L T L L S F M L L I C S L C K H L K K M Q L H G D P S T K V H I K A L Q T V I S F L L L C A I Y F L S I M I S V W S F G S K P V F M F C K A I R F S Y P S I H P F I L I W G N K K F L S M R Y L K Q T V F W Q W V
Helix box plot — Download: PNG | SVG G N A F N G I V F T V V V L S S F I I P 1 T A L A V S R V G L L W V L L L N W Y S 2 T T A L W N S F H N I V A W I N Y A T T 3 I L V M L L G P L L F L A C H L F V I N 4 F S L L T L T F P V L N A V M T V T M N 5 V I S F L L L C A I Y F L S I M I S V W 6 F P H I S P Y S F R I A K C F M F V P 7

GPCRdb(A)
GPCRdb(A)
TAS2R43
TM2
2x60 2.60x60 N65
TM3
3x28 3.28x28 A84
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM5
5x40 5.39x40 N176
5x44 5.43x44 T180
TM6
6x55 6.55x55 S248
6x56 6.56x56 V249
6x59 6.59x59 F252
TM7
7x41 7.42x41 R268