PDB
9S37
Resolution
3.9 Å
Released
July 30, 2025
Receptor
LGR4
Class
A
Species
Homo sapiens
Ligand
NB21
Function
Antagonist
Reference
10.1038/S41467-025-63410-5

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Ligand Amino Acid Generic Number Segment Interaction Type
NB21 A89 N-term hydrophobic
NB21 Q113 N-term polar (hydrogen bond)
NB21 Q113 N-term Van der Waals
NB21 N114 N-term Van der Waals
NB21 S133 N-term Van der Waals
NB21 R135 N-term Van der Waals
NB21 H157 N-term Van der Waals
NB21 W159 N-term Van der Waals
NB21 W159 N-term aromatic (face-to-edge)
NB21 D161 N-term Van der Waals
NB21 L186 N-term Van der Waals
NB21 L186 N-term hydrophobic
NB21 H207 N-term Van der Waals
NB21 T229 N-term Van der Waals
NB21 D231 N-term polar (charge-assisted hydrogen bond)
NB21 N233 N-term polar (hydrogen bond)
NB21 N233 N-term Van der Waals
NB21 Y234 N-term Van der Waals
NB21 E252 N-term polar (charge-assisted hydrogen bond)
NB21 G254 N-term Van der Waals
NB21 H278 N-term Van der Waals
NB21 Y280 N-term Van der Waals
NB21 R346 N-term polar (charge-assisted hydrogen bond)

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Helix box plot — Download: PNG | SVG L N F F L A V L F I F W V T L R I M W S 1 G L I S V S N L F M G I Y T G I L T F L 2 L M L L F I A S E S S F V A L F G A V K 3 F R V A A L L A F L G A T V A G C F P L 4 Y I V A M L L F A L S N L L V L T V T F 5 A W L I F T N C I F F C P V A F F S F A 6 V P N L C A P L P F F I L T V S K M I 7

GPCRdb(A)
GPCRdb(A)
LGR4