PDB
9UXO
Resolution
3.0 Å
Released
May 27, 2026
Receptor
oxoglutarate
Class
A
Species
Homo sapiens
Ligand
maleic acid
Function
Agonist
Reference
10.1038/S44318-026-00823-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
maleic acid Y40 1.39x39 TM1 polar (hydrogen bond)
maleic acid Y40 1.39x39 TM1 Van der Waals
maleic acid L89 2.60x60 TM2 Van der Waals
maleic acid Y93 2.64x64 TM2 Van der Waals
maleic acid R110 3.29x29 TM3 polar (charge-assisted hydrogen bond)
maleic acid F113 3.32x32 TM3 hydrophobic
maleic acid F113 3.32x32 TM3 Van der Waals
maleic acid H114 3.33x33 TM3 Van der Waals
maleic acid R288 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M R P W ICL1ECL1 G E N W I F ECL1ICL2 P M S C F S I H ICL2ECL2 T S T N R T N R S A C L D L T S S D E ECL2ICL3 G L Q T ICL3ECL3 R L L S I ECL3N-term M N E P L D Y L A N A S D F P D Y A A A F G N C T D E N I P N-termC-term C K V S G N L E Q A K K I S Y S N N P C-term L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H K T R C A V V A C A V V W I I S L V A V I P M T F L I L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N V C S F Q Q A T V R
Helix box plot — Download: PNG | SVG A N G P F G V L F I I G Y I V P L Y H M 1 L N L A C T D L L Y L T S L P F L I H Y 2 C T L F L I S S Y L N F H F S F R I F K 3 A V V A C A V V W I I S L V A V I P M 4 Y C L T V I V L P L C F T T A T L I L N Y 5 I L L L L A F Y V C F L P F H I L R V I 6 L L N G F T N L A A L P R S V I Y A E 7

GPCRdb(A)
GPCRdb(A)
oxoglutarate receptor
TM1
1x39 1.39x39 Y40
TM2
2x60 2.60x60 L89
2x64 2.64x64 Y93
TM3
3x29 3.29x29 R110
3x32 3.32x32 F113
3x33 3.33x33 H114
TM7
7x38 7.39x38 R288