PDB
9VIF
Resolution
3.2 Å
Released
Dec. 3, 2025
Receptor
NPFF1
Class
A
Species
Homo sapiens
Ligand
neuropeptide FF (Human)
Function
Agonist
Reference
10.1093/PROCEL/PWAF090

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Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF (Human) V127 3.36x36 TM3 hydrophobic
neuropeptide FF (Human) S176 4.60x61 TM4 polar (hydrogen bond)
neuropeptide FF (Human) S176 4.60x61 TM4 Van der Waals
neuropeptide FF (Human) E205 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
neuropeptide FF (Human) W287 6.52x52 TM6 Van der Waals
neuropeptide FF (Human) W287 6.52x52 TM6 aromatic (face-to-edge)
neuropeptide FF (Human) L290 6.55x55 TM6 Van der Waals
neuropeptide FF (Human) I293 6.58x58 TM6 Van der Waals
neuropeptide FF (Human) T307 7.31x30 TM7 Van der Waals
neuropeptide FF (Human) H315 7.39x38 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R H M H ICL1ECL1 G W P F ECL1ICL2 P F R E K L ICL2ECL2 T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K ECL2ICL3 G G E E A ICL3ECL3 Q L S A P Q L ECL3N-term M E G E P S Q P P N S S W P L S Q N G T N T E A T P A T N L T F S S Y Y Q H T S P V N-termC-term P R P S G S H K E A Y S E R P G G L L H R R V F V V V R P S D S G L P S E S G P S S G A P R P G R L P L R N G R V A H H G L P R E G P G C S H L P L T I P A W D I C-term A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H T L R K A L V T I A V I W A L A L L I M C P S A V T L G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P G P A P A D P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F Q A R L C F R R G A F R A
Helix box plot — Download: PNG | SVG T N G V M C L L F I L A Y A V I F M A A 1 L N L A V S D L L V G F I C M P T T L V D 2 A V L T F V S A S V S M G Q V L G S M K 3 A L V T I A V I W A L A L L I M C P S 4 Y M V V I L A L P A L Y I H S F L V T T Y 5 V M V A L F F T L S W L P L W A L L L L 6 I P N A S S N F F A L W H A F P F A Y 7

GPCRdb(A)
GPCRdb(A)
NPFF1 receptor
TM3
3x36 3.36x36 V127
TM4
4x61 4.60x61 S176
ECL2
45x52 45.52x52 E205
TM6
6x52 6.52x52 W287
6x55 6.55x55 L290
6x58 6.58x58 I293
TM7
7x30 7.31x30 T307
7x38 7.39x38 H315