PGE2


SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O
InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 12
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 7CX2 7D7M 6AK3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP1 PE2R1 Human Prostanoid A pKd 7.6 7.75 7.9 Guide to Pharmacology
EP1 PE2R1 Human Prostanoid A pKi 7.3 7.65 8.0 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pKi 7.66 7.66 7.66 ChEMBL
EP3 PE2R3 Mouse Prostanoid A pKi 8.3 8.3 8.3 ChEMBL
EP1 PE2R1 Human Prostanoid A pKi 7.75 7.94 8.04 ChEMBL
EP2 PE2R2 Human Prostanoid A pKi 7.42 8.35 8.99 ChEMBL
EP3 PE2R3 Human Prostanoid A pKi 8.3 8.98 9.48 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 8.51 9.2 9.96 ChEMBL
DP1 PD2R Human Prostanoid A pKi 8.15 8.15 8.15 Drug Central
DP2 PD2R2 Human Prostanoid A pKi 8.28 8.28 8.28 Drug Central
DP1 PD2R Human Prostanoid A pKi 6.5 6.75 7.0 Guide to Pharmacology
DP1 PD2R Human Prostanoid A pKi 6.51 6.51 6.51 PDSP Ki database
DP2 PD2R2 Human Prostanoid A pKi 5.3 5.3 5.3 Guide to Pharmacology
EP1 PE2R1 Human Prostanoid A pKi 8.04 8.04 8.04 PDSP Ki database
EP1 PE2R1 Human Prostanoid A pKi 8.09 8.09 8.09 Drug Central
EP2 PE2R2 Human Prostanoid A pKi 7.5 7.9 8.3 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKd 7.7 7.8 7.9 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 8.06 8.06 8.06 Drug Central
EP3 PE2R3 Human Prostanoid A pKd 8.2 8.73 9.5 Guide to Pharmacology
EP3 PE2R3 Human Prostanoid A pKi 9.48 9.48 9.48 Guide to Pharmacology
EP3 PE2R3 Human Prostanoid A pKi 9.48 9.48 9.48 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 8.02 8.02 8.02 Drug Central
EP4 PE2R4 Human Prostanoid A pKi 8.1 8.6 9.1 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKd 7.62 8.57 9.52 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKi 8.31 8.71 9.1 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 8.01 8.01 8.01 Drug Central
FP PF2R Human Prostanoid A pKi 6.4 6.65 6.9 Guide to Pharmacology
FP PF2R Human Prostanoid A pKi 6.92 6.92 6.92 PDSP Ki database
FP PF2R Human Prostanoid A pKi 8.16 8.16 8.16 Drug Central
IP PI2R Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
TP TA2R Human Prostanoid A pKi 4.5 4.5 4.5 Guide to Pharmacology
TP TA2R Human Prostanoid A pKi 8.35 8.35 8.35 Drug Central
EP1 PE2R1 Mouse Prostanoid A pKi 7.7 7.7 7.7 Guide to Pharmacology
EP1 PE2R1 Mouse Prostanoid A pKi 8.22 8.22 8.22 ChEMBL
EP1 PE2R1 Mouse Prostanoid A pKi 7.7 7.7 7.7 PDSP Ki database
EP1 PE2R1 Mouse Prostanoid A pKi 8.09 8.09 8.09 Drug Central
TP TA2R Mouse Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP3 PE2R3 Rat Prostanoid A pKd 7.82 8.72 9.1 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 9.0 9.0 9.0 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKi 9.07 9.07 9.07 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKd 8.85 8.85 8.85 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKi 9.07 9.07 9.07 PDSP Ki database
EP3 PE2R3 Mouse Prostanoid A pKi 8.08 8.08 8.08 Drug Central
EP1 PE2R1 Rat Prostanoid A pKi 7.7 7.7 7.7 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKd 7.3 7.45 7.6 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKi 8.11 8.11 8.11 Drug Central
FP PF2R Mouse Prostanoid A pKi 7.0 7.0 7.0 Guide to Pharmacology
FP PF2R Mouse Prostanoid A pKi 7.0 7.0 7.0 PDSP Ki database
FP PF2R Mouse Prostanoid A pKi 8.15 8.15 8.15 Drug Central
FP PF2R Bovine Prostanoid A pKi 5.47 5.47 5.47 PDSP Ki database
DP2 PD2R2 Mouse Prostanoid A pKi 5.5 5.5 5.5 Guide to Pharmacology
DP2 PD2R2 Mouse Prostanoid A pKi 8.26 8.26 8.26 Drug Central
EP2 PE2R2 Rat Prostanoid A pKi 8.2 8.2 8.2 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pKd 7.8 8.05 8.3 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 9.0 9.0 9.0 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKd 9.0 9.0 9.0 Guide to Pharmacology
EP3 PE2R3 Bovine Prostanoid A pKi 8.4 8.46 8.52 PDSP Ki database
EP4 PE2R4 Mouse Prostanoid A pKi 8.52 8.61 8.7 Guide to Pharmacology
EP4 PE2R4 Mouse Prostanoid A pKd 8.6 8.6 8.6 Guide to Pharmacology
EP4 PE2R4 Mouse Prostanoid A pKi 8.51 8.51 8.51 ChEMBL
EP4 PE2R4 Mouse Prostanoid A pKi 8.72 8.72 8.72 PDSP Ki database
EP4 PE2R4 Mouse Prostanoid A pKi 8.07 8.07 8.07 Drug Central
IP PI2R Mouse Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
DP1 PD2R Rat Prostanoid A pKi 5.53 5.53 5.53 PDSP Ki database
EP2 PE2R2 Mouse Prostanoid A pKi 7.4 7.65 7.9 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pKd 7.7 7.7 7.7 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pKi 7.92 7.92 7.92 PDSP Ki database
EP2 PE2R2 Mouse Prostanoid A pKi 8.12 8.12 8.12 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Rat Prostanoid A pIC50 8.28 8.28 8.28 ChEMBL
EP2 PE2R2 Rat Prostanoid A pEC50 7.72 8.71 9.7 ChEMBL
IP PI2R Human Prostanoid A pIC50 6.58 6.58 6.58 ChEMBL
IP PI2R Human Prostanoid A pEC50 6.46 6.46 6.46 ChEMBL
EP1 PE2R1 Human Prostanoid A pIC50 8.96 8.96 8.96 ChEMBL
EP1 PE2R1 Human Prostanoid A pEC50 8.43 8.43 8.43 ChEMBL
EP2 PE2R2 Human Prostanoid A pIC50 7.42 8.36 8.66 ChEMBL
EP2 PE2R2 Human Prostanoid A pEC50 6.46 7.67 8.72 ChEMBL
EP3 PE2R3 Human Prostanoid A pEC50 8.6 8.6 8.6 ChEMBL
EP3 PE2R3 Human Prostanoid A pIC50 9.03 9.03 9.03 ChEMBL
EP4 PE2R4 Human Prostanoid A pIC50 8.0 8.78 9.35 ChEMBL
EP4 PE2R4 Human Prostanoid A pEC50 8.12 9.02 10.7 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 8.0 8.0 8.0 ChEMBL
EP4 PE2R4 Human Prostanoid A pEC50 6.05 6.05 6.05 Guide to Pharmacology
FP PF2R Human Prostanoid A pEC50 6.6 6.6 6.6 ChEMBL
IP PI2R Human Prostanoid A pIC50 8.18 8.18 8.18 Drug Central
EP3 PE2R3 Rat Prostanoid A pEC50 9.39 9.39 9.39 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pEC50 8.03 8.03 8.03 Drug Central
EP2 PE2R2 Rat Prostanoid A pIC50 8.08 8.08 8.08 Drug Central
EP4 PE2R4 Rat Prostanoid A pIC50 8.68 8.68 8.68 ChEMBL
EP4 PE2R4 Rat Prostanoid A pEC50 8.46 8.8 9.15 ChEMBL
EP4 PE2R4 Rat Prostanoid A pIC50 8.06 8.06 8.06 Drug Central