ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155524115	183326	0	None	-1	3	Rat	10.3	pEC50	=	10.3	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4454158	183326	0	None	-1	3	Rat	10.3	pEC50	=	10.3	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4597218	183326	0	None	-1	3	Rat	10.3	pEC50	=	10.3	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	155524115	183326	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4454158	183326	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4597218	183326	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	155524115	183326	0	None	-4	3	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4454158	183326	0	None	-4	3	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4597218	183326	0	None	-4	3	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
	46235428	13376	0	None	263	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083162	13376	0	None	263	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	58227401	183230	0	None	2	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4443126	183230	0	None	2	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596409	183230	0	None	2	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	58227401	183230	0	None	-2	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4443126	183230	0	None	-2	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596409	183230	0	None	-2	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	155513612	183099	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	-18	3	Rat	9.2	pEC50	=	9.2	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	51354300	65663	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	CHEMBL1688946	65663	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	155491015	183274	4	None	-10	4	Mouse	9.0	pEC50	=	9	Functional	Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assayAgonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4441731	183274	4	None	-10	4	Mouse	9.0	pEC50	=	9	Functional	Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assayAgonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4596734	183274	4	None	-10	4	Mouse	9.0	pEC50	=	9	Functional	Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assayAgonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	155513612	183099	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	-14	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	58227401	183230	0	None	-2	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4443126	183230	0	None	-2	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596409	183230	0	None	-2	3	Mouse	9.0	pEC50	=	9.0	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	45257132	10454	10	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	8983	10454	10	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	CHEMBL595180	10454	10	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	155552061	183257	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4543119	183257	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596606	183257	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	155517880	183446	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4445423	183446	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4598198	183446	0	None	2	3	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	45257132	10454	10	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	8983	10454	10	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	CHEMBL595180	10454	10	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
	58227373	183287	0	None	-1	3	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4455324	183287	0	None	-1	3	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596881	183287	0	None	-1	3	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	155513612	183099	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	14	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	136030655	63256	0	None	1	3	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632413	63256	0	None	1	3	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	136030655	63256	0	None	-1	3	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632413	63256	0	None	-1	3	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	25068753	195217	19	None	-1	2	Rat	8.0	pEC50	=	8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL502347	195217	19	None	-1	2	Rat	8.0	pEC50	=	8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	10105117	110972	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL309819	110972	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	127051301	146978	0	None	4	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804906	146978	0	None	4	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	136141537	63255	3	None	1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632412	63255	3	None	1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	4024	8796	20	None	-3388	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	9989505	8796	20	None	-3388	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL82298	8796	20	None	-3388	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	58227259	123920	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393556	123920	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	1194	6834	3	None	-50	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	23786499	6834	3	None	-50	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	CHEMBL26116	6834	3	None	-50	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	24797598	68336	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1771001	68336	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	11846299	145998	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
	CHEMBL378788	145998	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
	46228114	206955	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL596551	206955	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	25130576	194405	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL494890	194405	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	25130232	194342	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cn(C)cn3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494576	194342	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cn(C)cn3)nc(N)n2)CC1	10.1021/jm8005959
	25131229	194374	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	CHEMBL494724	194374	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	25130576	194405	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	CHEMBL494890	194405	1	None	2	2	Mouse	7.0	pEC50	=	7.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	11846635	85455	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
	CHEMBL211242	85455	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
	46228132	208924	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
	CHEMBL609161	208924	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as inhibition of 100 nM dopamine-induced stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
	25129178	194408	1	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL494910	194408	1	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	1267	10576	49	None	-17	5	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm900526h
	3035905	10576	49	None	-17	5	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm900526h
	CHEMBL260374	10576	49	None	-17	5	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm900526h
	44480708	12547	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(/NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1021/jm900526h
	CHEMBL1078632	12547	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(/NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1021/jm900526h
	53233804	68300	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770966	68300	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	1204	8713	119	None	-3	11	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	1247	8713	119	None	-3	11	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	1375	8713	119	None	-3	11	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	774	8713	119	None	-3	11	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	CHEMBL90	8713	119	None	-3	11	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	DB05381	8713	119	None	-3	11	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
	127052293	147016	3	None	10	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805361	147016	3	None	10	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1247	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1375	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	774	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	CHEMBL90	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	DB05381	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	45257131	206687	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	CHEMBL594731	206687	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	56593499	147020	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	3	4	3.2	N#C/N=C(/NCCSc1ccccc1)N[C@H]1CC[C@@H](c2c[nH]cn2)CC1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805392	147020	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	6	3	4	3.2	N#C/N=C(/NCCSc1ccccc1)N[C@H]1CC[C@@H](c2c[nH]cn2)CC1	10.1021/acs.jmedchem.6b00120
	127050776	147025	0	None	3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805437	147025	0	None	3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	127050431	147093	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806206	147093	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	58227165	123900	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393536	123900	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	25130578	194112	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	251	4	1	5	1.4	CN(C)CCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL493099	194112	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	251	4	1	5	1.4	CN(C)CCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	25129525	194362	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL494648	194362	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	25128833	195181	38	None	-2	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	CHEMBL501882	195181	38	None	-2	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	25128831	179392	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL449157	179392	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	11043445	63253	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL1632410	63253	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	16061839	195197	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	284	3	2	6	1.6	CN1CCN(c2cc(Nc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL502104	195197	0	None	-	1	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	284	3	2	6	1.6	CN1CCN(c2cc(Nc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	127050431	147093	0	None	3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806206	147093	0	None	3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	54585780	68332	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770998	68332	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	1204	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	1247	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	1375	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	774	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	CHEMBL90	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	DB05381	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	25130914	194033	0	None	15	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
	CHEMBL492677	194033	0	None	15	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
	11957573	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	1250	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	3692	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	CHEMBL19439	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm100064d
	11957573	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1250	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	3692	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL19439	8791	34	None	-54	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1253	8839	7	None	-251	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	132937	8839	7	None	-251	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL19010	8839	7	None	-251	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	10176414	10835	16	None	-25	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1246	10835	16	None	-25	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL281576	10835	16	None	-25	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1204	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1267	10576	49	None	-17	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	3035905	10576	49	None	-17	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	CHEMBL260374	10576	49	None	-17	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	44482032	12504	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	262	7	3	3	1.4	CC(C)CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1078346	12504	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	262	7	3	3	1.4	CC(C)CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	25130581	194004	0	None	3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	CHEMBL492489	194004	0	None	3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	44482029	12408	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1cccnc1	10.1021/jm900526h
	CHEMBL1077737	12408	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1cccnc1	10.1021/jm900526h
	25131234	194441	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccccc3C#N)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL495083	194441	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccccc3C#N)nc(N)n2)CC1	10.1021/jm8005959
	25130235	194366	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	194366	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at mouse histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	25130235	194366	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	CHEMBL494678	194366	1	None	4	3	Mouse	6.9	pEC50	=	6.9	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	25130234	194182	0	None	-	1	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	2	6	-0.7	CN1CCN(c2cc(N3CCNC3=O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493663	194182	0	None	-	1	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	2	6	-0.7	CN1CCN(c2cc(N3CCNC3=O)nc(N)n2)CC1	10.1021/jm8005959
	127051986	147082	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806098	147082	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	51354301	65666	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
	CHEMBL1688969	65666	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
	10934158	115354	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL320331	115354	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	10017821	110563	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL308913	110563	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
	1238	8863	13	None	-1258	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	6603865	8863	13	None	-1258	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	CHEMBL11919	8863	13	None	-1258	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	11043445	63253	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632410	63253	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	10945113	116406	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL322256	116406	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	44480707	12535	0	None	5	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	328	8	3	4	2.2	N#C/N=C(/NCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	CHEMBL1078529	12535	0	None	5	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	328	8	3	4	2.2	N#C/N=C(/NCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	10945113	116406	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL322256	116406	1	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	127052294	147080	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806079	147080	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1247	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	1375	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	774	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	CHEMBL90	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	DB05381	8713	119	None	-3	11	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2009.08.059
	10934158	115354	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL320331	115354	1	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	25129182	194062	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	291	2	1	7	-0.4	CN1CCN(c2cc(N3CCN(C)CC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492869	194062	0	None	-	1	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	291	2	1	7	-0.4	CN1CCN(c2cc(N3CCN(C)CC3)nc(N)n2)CC1	10.1021/jm8005959
	127052293	147016	3	None	10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805361	147016	3	None	10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	11846634	84784	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	CHEMBL209758	84784	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	11846464	85235	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
	CHEMBL211170	85235	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
	25071319	195841	14	None	1	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL509540	195841	14	None	1	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	44482030	12447	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	338	9	3	3	2.9	CC(CCN/C(=N\C#N)NCCCCc1c[nH]cn1)c1ccccc1	10.1021/jm900526h
	CHEMBL1077860	12447	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	338	9	3	3	2.9	CC(CCN/C(=N\C#N)NCCCCc1c[nH]cn1)c1ccccc1	10.1021/jm900526h
	25131561	194183	0	None	-3	2	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493664	194183	0	None	-3	2	Rat	4.9	pEC50	=	4.9	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	135897837	194407	13	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	209	1	2	6	-0.5	CN1CCN(c2cc(O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494909	194407	13	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	209	1	2	6	-0.5	CN1CCN(c2cc(O)nc(N)n2)CC1	10.1021/jm8005959
	127048828	147098	0	None	38	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806255	147098	0	None	38	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	58227255	123903	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393539	123903	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	44568832	193962	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	2	1	6	1.2	CN1CCN(c2cc(-c3ccc(F)nc3F)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492242	193962	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	2	1	6	1.2	CN1CCN(c2cc(-c3ccc(F)nc3F)nc(N)n2)CC1	10.1021/jm8005959
	25128822	194260	0	None	19	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
	CHEMBL494093	194260	0	None	19	2	Rat	7.8	pEC50	=	7.8	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
	1251	8795	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm100064d
	3035842	8795	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm100064d
	CHEMBL18661	8795	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptorAgonist activity at human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm100064d
	1251	8795	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	3035842	8795	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	CHEMBL18661	8795	39	None	-204	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	25149712	185765	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	299	7	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL470790	185765	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	299	7	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1	10.1016/j.bmcl.2010.10.041
	25149335	191004	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL483406	191004	0	None	-6	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	1278	8931	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	1279	8931	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	4908365	8931	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	CHEMBL129198	8931	84	None	1	4	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
	127048890	147073	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805995	147073	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	46890548	13356	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083084	13356	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	44481761	12546	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	324	9	3	3	2.4	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccc1	10.1021/jm900526h
	CHEMBL1078631	12546	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	324	9	3	3	2.4	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccc1	10.1021/jm900526h
	51354301	65666	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	CHEMBL1688969	65666	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
	155513612	183099	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	1204	8713	119	None	-288	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	8713	119	None	-288	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	8713	119	None	-288	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	8713	119	None	-288	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	8713	119	None	-288	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	8713	119	None	-288	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1248	8206	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	3077	8206	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	90045	8206	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	CHEMBL12344	8206	28	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
	5310982	100387	4	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
	CHEMBL24665	100387	4	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
	1269	6909	41	None	-35	6	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse histamine H4 receptorAgonist activity at mouse histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	6909	41	None	-35	6	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse histamine H4 receptorAgonist activity at mouse histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	6909	41	None	-35	6	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse histamine H4 receptorAgonist activity at mouse histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	53233802	68321	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770987	68321	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
	25131559	194364	0	None	23	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494667	194364	0	None	23	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	1204	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1204	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1247	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1375	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	774	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	CHEMBL90	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	DB05381	8713	119	None	-3	11	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	44480959	12448	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	206	5	3	3	0.1	N#C/N=C(\N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077861	12448	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	206	5	3	3	0.1	N#C/N=C(\N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	1484519	180675	60	None	-	1	Rat	4.8	pEC50	=	4.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	227	1	1	5	0.5	CN1CCN(c2cc(Cl)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL454007	180675	60	None	-	1	Rat	4.8	pEC50	=	4.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	227	1	1	5	0.5	CN1CCN(c2cc(Cl)nc(N)n2)CC1	10.1021/jm8005959
	21638785	195437	5	None	1	2	Mouse	7.8	pEC50	=	7.8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	CHEMBL503605	195437	5	None	1	2	Mouse	7.8	pEC50	=	7.8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	127051958	147056	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805813	147056	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	165	2	2	2	1.3	NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	25129880	199909	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	2	1	5	2.6	CN1CCN(c2cc(-c3ccc4ccccc4c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL522841	199909	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	2	1	5	2.6	CN1CCN(c2cc(-c3ccc4ccccc4c3)nc(N)n2)CC1	10.1021/jm8005959
	25130231	194483	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	309	2	1	7	1.2	CN1CCN(c2cc(-n3cnc4ccccc43)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL495280	194483	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	309	2	1	7	1.2	CN1CCN(c2cc(-n3cnc4ccccc43)nc(N)n2)CC1	10.1021/jm8005959
	25131228	194373	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL494723	194373	0	None	-	1	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25128828	195031	2	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	237	4	2	5	1.3	CN(C)CCNc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL499631	195031	2	None	-	1	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	237	4	2	5	1.3	CN(C)CCNc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	58227163	183242	0	None	4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4518374	183242	0	None	4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596491	183242	0	None	4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	25071319	195841	14	None	-1	2	Mouse	7.7	pEC50	=	7.7	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL509540	195841	14	None	-1	2	Mouse	7.7	pEC50	=	7.7	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	1204	8713	119	None	-3	11	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	1247	8713	119	None	-3	11	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	1375	8713	119	None	-3	11	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	774	8713	119	None	-3	11	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	CHEMBL90	8713	119	None	-3	11	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	DB05381	8713	119	None	-3	11	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	25130233	177392	7	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3cn[nH]c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL445091	177392	7	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3cn[nH]c3)nc(N)n2)CC1	10.1021/jm8005959
	25128831	179392	0	None	-1	2	Rat	4.7	pEC50	=	4.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL449157	179392	0	None	-1	2	Rat	4.7	pEC50	=	4.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	277	2	0	5	1.6	CN1CCN(c2cc(C(C)(C)C)nc(N(C)C)n2)CC1	10.1021/jm8005959
	25130574	194155	0	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(N)nc(-c3ccc(C#N)cc3)c2)CC1	10.1021/jm8005959
	CHEMBL493461	194155	0	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(N)nc(-c3ccc(C#N)cc3)c2)CC1	10.1021/jm8005959
	44568790	178193	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	2	2	5	1.4	CN[C@@H]1CCN(c2nc(N)nc3c2Cc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL446269	178193	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	2	2	5	1.4	CN[C@@H]1CCN(c2nc(N)nc3c2Cc2ccccc2-3)C1	10.1021/jm800670r
	155552061	183257	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4543119	183257	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596606	183257	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	45257133	206683	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594721	206683	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	11846300	87041	3	None	-2	2	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL213912	87041	3	None	-2	2	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
	1204	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	3032915	22267	24	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL12160	22267	24	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	53321919	63252	0	None	-50	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632409	63252	0	None	-50	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	10060213	109688	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL306077	109688	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	25128823	199496	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
	CHEMBL521995	199496	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
	25131230	199888	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	329	4	1	7	1.5	COc1cccc(OC)c1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL522679	199888	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	329	4	1	7	1.5	COc1cccc(OC)c1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	10037650	11981	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106158	11981	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	170389	213760	35	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL4634086	213760	35	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL91353	213760	35	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	155513612	183099	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	-14	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	136141537	63255	3	None	-1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632412	63255	3	None	-1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	136192874	63257	0	None	-3	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632414	63257	0	None	-3	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	46228133	206833	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL595639	206833	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	10197870	12073	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106612	12073	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	10197870	12073	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106612	12073	0	None	-47	2	Human	5.7	pEC50	=	5.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10879463	12062	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106570	12062	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	1278	8931	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	1279	8931	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	4908365	8931	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	CHEMBL129198	8931	84	None	-1	4	Mouse	8.6	pEC50	=	8.6	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	1278	8931	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	1279	8931	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	4908365	8931	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	CHEMBL129198	8931	84	None	-1	4	Rat	8.6	pEC50	=	8.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
	58227260	123910	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393546	123910	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
	11846636	84727	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	CHEMBL209628	84727	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
	1204	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	1247	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	1375	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	774	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	CHEMBL90	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	DB05381	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
	16061961	206458	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL593103	206458	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	1204	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	1247	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	1375	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	774	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	CHEMBL90	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	DB05381	8713	119	None	-3	11	Human	7.7	pEC50	=	7.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0300025
	127052635	146985	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805003	146985	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	25130237	194061	2	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	1	1	5	0.4	CN1CCN(c2cc(I)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492864	194061	2	None	-	1	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	319	1	1	5	0.4	CN1CCN(c2cc(I)nc(N)n2)CC1	10.1021/jm8005959
	127051301	146978	0	None	4	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804906	146978	0	None	4	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	25131555	193958	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3cccnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492227	193958	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3cccnc3)nc(N)n2)CC1	10.1021/jm8005959
	25130914	194033	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL492677	194033	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	10879463	12062	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106570	12062	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	1613	9127	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	205	9127	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	3964	9127	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	CHEMBL831	9127	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	DB00408	9127	53	None	-26	34	Human	6.7	pEC50	=	6.7	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
	753256	186129	12	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL473662	186129	12	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1021/jm8005959
	25131560	194125	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cnn(C)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493229	194125	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	273	2	1	7	0.2	CN1CCN(c2cc(-c3cnn(C)c3)nc(N)n2)CC1	10.1021/jm8005959
	1223	7740	41	None	-21	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	2790	7740	41	None	-21	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	CHEMBL14690	7740	41	None	-21	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	155512725	183020	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4437371	183020	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4594753	183020	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	10037650	11981	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106158	11981	0	None	47	2	Human	6.7	pEC50	=	6.7	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	25129881	193961	5	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3ccncc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492241	193961	5	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	270	2	1	6	0.9	CN1CCN(c2cc(-c3ccncc3)nc(N)n2)CC1	10.1021/jm8005959
	44568855	199973	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	285	2	1	5	2.0	CC(C)(C)c1cc(N2CCNCC2)nc(-n2cccc2)n1	10.1021/jm8005959
	CHEMBL523335	199973	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	285	2	1	5	2.0	CC(C)(C)c1cc(N2CCNCC2)nc(-n2cccc2)n1	10.1021/jm8005959
	25128832	178791	0	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	5	1.2	CN1CCN(c2cc(C(C)(C)C)nc(O)n2)CC1	10.1021/jm8005959
	CHEMBL447151	178791	0	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	5	1.2	CN1CCN(c2cc(C(C)(C)C)nc(O)n2)CC1	10.1021/jm8005959
	25071940	194133	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
	CHEMBL493281	194133	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
	127049156	146972	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804837	146972	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	11437850	194440	1	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3cccc(C#N)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL495082	194440	1	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3cccc(C#N)c3)nc(N)n2)CC1	10.1021/jm8005959
	25129883	199502	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ccncc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL522019	199502	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ccncc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25133972	194129	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(-c3ccc(C#N)cc3)cc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493262	194129	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	293	2	1	5	2.0	CN1CCN(c2cc(-c3ccc(C#N)cc3)cc(N)n2)CC1	10.1021/jm8005959
	25130575	194368	1	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.6	CC1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494687	194368	1	None	-	1	Rat	4.6	pEC50	=	4.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.6	CC1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	25130577	179377	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	4	1	6	1.0	CN(C)CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL449021	179377	0	None	-	1	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	306	4	1	6	1.0	CN(C)CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	10773349	14863	1	None	-89	2	Human	4.6	pEC50	=	4.6	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL109130	14863	1	None	-89	2	Human	4.6	pEC50	=	4.6	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	127052634	147087	0	None	6	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806146	147087	0	None	6	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	272	4	3	3	1.5	N#C/N=C(\NC[C@@H]1CC[C@H](c2c[nH]cn2)C1)NC1CC1	10.1021/acs.jmedchem.6b00120
	90667240	116256	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	356	9	3	4	2.8	Cc1[nH]cnc1CCCCN/C(=N\C#N)NCCSc1ccccc1	10.1039/C3MD00245D
	CHEMBL3220642	116256	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	356	9	3	4	2.8	Cc1[nH]cnc1CCCCN/C(=N\C#N)NCCSc1ccccc1	10.1039/C3MD00245D
	25130576	194405	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL494890	194405	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
	25128826	195595	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.5	CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL506187	195595	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.5	CCN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	25130576	194405	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	CHEMBL494890	194405	1	None	-2	2	Rat	6.6	pEC50	=	6.6	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
	58227157	122695	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3354815	122695	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
	1204	8713	119	None	-3	11	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	1247	8713	119	None	-3	11	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	1375	8713	119	None	-3	11	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	774	8713	119	None	-3	11	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	CHEMBL90	8713	119	None	-3	11	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	DB05381	8713	119	None	-3	11	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
	1226	8800	20	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
	41376	8800	20	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
	CHEMBL12608	8800	20	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
	25133970	194367	2	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL494679	194367	2	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	25130230	179235	2	None	3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL448085	179235	2	None	3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	1269	6909	41	None	-56	6	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptorAgonist activity at rat histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	6909	41	None	-56	6	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptorAgonist activity at rat histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	6909	41	None	-56	6	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat histamine H4 receptorAgonist activity at rat histamine H4 receptor	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	44480958	12445	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccncc1	10.1021/jm900526h
	CHEMBL1077859	12445	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccncc1	10.1021/jm900526h
	25131556	195650	7	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL507063	195650	7	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	127051047	147089	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806162	147089	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	45257134	206722	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
	CHEMBL594949	206722	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
	25131231	193966	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(I)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492288	193966	0	None	-	1	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(I)cc3)nc(N)n2)CC1	10.1021/jm8005959
	10381810	211953	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL7828	211953	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
	155512725	183020	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4437371	183020	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4594753	183020	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	127052294	147080	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3806079	147080	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	8713	119	None	-288	11	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	8713	119	None	-288	11	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	8713	119	None	-288	11	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	8713	119	None	-288	11	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	8713	119	None	-288	11	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	8713	119	None	-288	11	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	25128822	194260	0	None	-19	2	Human	6.5	pEC50	=	6.5	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	CHEMBL494093	194260	0	None	-19	2	Human	6.5	pEC50	=	6.5	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	155491015	183274	4	None	-31	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assayAgonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4441731	183274	4	None	-31	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assayAgonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	CHEMBL4596734	183274	4	None	-31	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assayAgonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
	46890072	13682	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084355	13682	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46890166	14088	0	None	3	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086105	14088	0	None	3	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	58227373	183287	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4455324	183287	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596881	183287	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	21638785	195437	5	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	CHEMBL503605	195437	5	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
	25130911	192009	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	236	2	1	6	-0.1	CN1CCN(c2cc(N(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL485802	192009	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	236	2	1	6	-0.1	CN1CCN(c2cc(N(C)C)nc(N)n2)CC1	10.1021/jm8005959
	16352	123963	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL339414	123963	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
	1267	10576	49	None	-8	5	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	3035905	10576	49	None	-8	5	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	CHEMBL260374	10576	49	None	-8	5	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
	25130579	194491	2	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	238	4	1	5	1.3	CN(C)CCOc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL495341	194491	2	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	238	4	1	5	1.3	CN(C)CCOc1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	10678661	12134	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106931	12134	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	46228101	206577	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594022	206577	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	1249	8790	16	None	-18	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	13499360	8790	16	None	-18	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90019	8790	16	None	-18	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1269	6909	41	None	35	6	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	6909	41	None	35	6	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	6909	41	None	35	6	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	25129528	193965	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(Cl)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492287	193965	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(Cl)c3)nc(N)n2)CC1	10.1021/jm8005959
	44568923	199882	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	327	2	1	5	2.3	CN1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL522661	199882	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	327	2	1	5	2.3	CN1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)CC1	10.1021/jm8005959
	67087450	123914	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393550	123914	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	44547127	122696	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3354816	122696	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	58227148	123911	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393547	123911	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	10678661	12134	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106931	12134	1	None	-309	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	25131557	200038	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	8	0.3	COc1ncc(-c2cc(N3CCN(C)CC3)nc(N)n2)cn1	10.1021/jm8005959
	CHEMBL523835	200038	0	None	-	1	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	8	0.3	COc1ncc(-c2cc(N3CCN(C)CC3)nc(N)n2)cn1	10.1021/jm8005959
	25130909	194159	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	CHEMBL493478	194159	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	44478385	12548	6	None	20	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	CHEMBL1078642	12548	6	None	20	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
	46890549	13357	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083085	13357	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	44480960	12402	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	248	6	3	3	1.2	CC(C)N/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077636	12402	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	248	6	3	3	1.2	CC(C)N/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	42625303	187545	0	None	-2089	6	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	CHEMBL475621	187545	0	None	-2089	6	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	56954425	88856	0	None	-13	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	584	23	6	4	4.0	N/C(=N\C(=O)CCCCCCCCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165643	88856	0	None	-13	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	584	23	6	4	4.0	N/C(=N\C(=O)CCCCCCCCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	25130913	176966	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	278	2	1	7	-0.4	CN1CCN(c2cc(N3CCOCC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL444484	176966	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	278	2	1	7	-0.4	CN1CCN(c2cc(N3CCOCC3)nc(N)n2)CC1	10.1021/jm8005959
	1274	10836	16	None	-776	4	Rat	4.5	pEC50	=	4.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	3063228	10836	16	None	-776	4	Rat	4.5	pEC50	=	4.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	CHEMBL1196470	10836	16	None	-776	4	Rat	4.5	pEC50	=	4.5	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	155517880	183446	0	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4445423	183446	0	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4598198	183446	0	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	155552061	183257	0	None	-8	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4543119	183257	0	None	-8	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596606	183257	0	None	-8	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
	25129180	194030	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	4	1	6	0.7	CCN(CC)c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL492662	194030	0	None	-	1	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	4	1	6	0.7	CCN(CC)c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	3228743	194160	5	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL493479	194160	5	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	12769844	116255	0	None	-3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	234	5	3	3	0.7	CN/C(=N/C#N)NCCCCc1nc[nH]c1C	10.1039/C3MD00245D
	CHEMBL3220641	116255	0	None	-3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	234	5	3	3	0.7	CN/C(=N/C#N)NCCCCc1nc[nH]c1C	10.1039/C3MD00245D
	25129181	194031	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	305	3	1	7	-0.0	CN1CCN(c2cc(N3CCC(N(C)C)C3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492663	194031	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	305	3	1	7	-0.0	CN1CCN(c2cc(N3CCC(N(C)C)C3)nc(N)n2)CC1	10.1021/jm8005959
	25128825	194343	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.2	CN1CCC(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494585	194343	0	None	-	1	Rat	5.4	pEC50	=	5.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	248	1	1	4	2.2	CN1CCC(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	44478385	12548	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/acs.jmedchem.6b00120
	CHEMBL1078642	12548	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/acs.jmedchem.6b00120
	44478385	12548	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1039/C3MD00245D
	CHEMBL1078642	12548	6	None	20	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1039/C3MD00245D
	25129527	194193	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493720	194193	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm8005959
	24798596	206646	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594491	206646	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	127052292	147044	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805663	147044	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1274	10836	16	None	7	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	3063228	10836	16	None	7	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	CHEMBL1196470	10836	16	None	7	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	11846465	148710	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
	CHEMBL387054	148710	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
	25131559	194364	0	None	-23	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494667	194364	0	None	-23	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	2	6	0.2	CN1CCN(c2cc(-c3c[nH]cn3)nc(N)n2)CC1	10.1021/jm8005959
	25131561	194183	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL493664	194183	0	None	3	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	286	2	1	7	-0.0	CN1CCN(c2cc(-n3ccccc3=O)nc(N)n2)CC1	10.1021/jm8005959
	46235428	13376	0	None	-263	3	Mouse	7.4	pEC50	=	7.4	Functional	Intrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083162	13376	0	None	-263	3	Mouse	7.4	pEC50	=	7.4	Functional	Intrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at mouse histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	1269	6909	41	None	35	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	37463	6909	41	None	35	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL275443	6909	41	None	35	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
	136030655	63256	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632413	63256	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	25129523	194066	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492884	194066	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25129523	194066	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
	CHEMBL492884	194066	45	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
	70692530	82466	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
	CHEMBL2047474	82466	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
	91613	24759	34	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL12620	24759	34	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
	58227326	123906	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393542	123906	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
	58227373	183287	0	None	-3	3	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4455324	183287	0	None	-3	3	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596881	183287	0	None	-3	3	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
	25071004	199497	0	None	1	2	Mouse	8.4	pEC50	=	8.4	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL521996	199497	0	None	1	2	Mouse	8.4	pEC50	=	8.4	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	42625303	187545	0	None	-2	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	CHEMBL475621	187545	0	None	-2	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	25128824	199957	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	CHEMBL523225	199957	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	10702196	115345	1	None	-1	2	Human	4.4	pEC50	=	4.4	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL320279	115345	1	None	-1	2	Human	4.4	pEC50	=	4.4	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	56954320	88854	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	472	15	6	4	0.9	N/C(=N\C(=O)CCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165641	88854	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	472	15	6	4	0.9	N/C(=N\C(=O)CCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	1267	10576	49	None	-17	5	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2015.12.035
	3035905	10576	49	None	-17	5	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2015.12.035
	CHEMBL260374	10576	49	None	-17	5	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2015.12.035
	25129524	193963	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	CHEMBL492274	193963	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1cccc(-c2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1021/jm8005959
	25130909	194159	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	CHEMBL493478	194159	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2nc(N)ncc2N)CC1	10.1021/jm8005959
	1278	8931	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	1279	8931	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	4908365	8931	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	CHEMBL129198	8931	84	None	-1	4	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
	25128833	195181	38	None	2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	CHEMBL501882	195181	38	None	2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1021/jm8005959
	25129526	194192	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL493719	194192	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	299	3	1	6	1.5	COc1ccccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	24797248	206645	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594490	206645	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	127050434	147028	0	None	3	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	160	3	4	3	0.2	CC(=N)SCCNC(=N)N	10.1021/acs.jmedchem.6b00120
	CHEMBL3805514	147028	0	None	3	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	160	3	4	3	0.2	CC(=N)SCCNC(=N)N	10.1021/acs.jmedchem.6b00120
	25129169	193960	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	CHEMBL492231	193960	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	24798595	177155	2	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	276	2	1	6	0.8	CN1CCN(c2cc(N3CCCCC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL444782	177155	2	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	276	2	1	6	0.8	CN1CCN(c2cc(N3CCCCC3)nc(N)n2)CC1	10.1021/jm8005959
	90667239	116254	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	8	3	4	2.5	Cc1nc(CCCN/C(=N\C#N)NCCSc2ccccc2)c[nH]1	10.1039/C3MD00245D
	CHEMBL3220640	116254	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	342	8	3	4	2.5	Cc1nc(CCCN/C(=N\C#N)NCCSc2ccccc2)c[nH]1	10.1039/C3MD00245D
	25130573	193664	2	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL489663	193664	2	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(N)nc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	25130581	194004	0	None	-3	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	CHEMBL492489	194004	0	None	-3	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	264	2	0	5	1.5	COc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	25130235	194366	1	None	-4	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	194366	1	None	-4	3	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein by GTPgammaS assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	46890546	13287	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082771	13287	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46228143	206862	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL595880	206862	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	117724523	123893	2	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393529	123893	2	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
	25130914	194033	0	None	-15	2	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492677	194033	0	None	-15	2	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25129179	194447	4	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	222	2	2	6	-0.1	CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL495112	194447	4	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	222	2	2	6	-0.1	CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25130236	194480	0	None	1	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	CHEMBL495265	194480	0	None	1	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	25068753	195217	19	None	1	2	Mouse	8.2	pEC50	=	8.2	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	CHEMBL502347	195217	19	None	1	2	Mouse	8.2	pEC50	=	8.2	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
	53233805	68298	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770964	68298	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	46890545	14157	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086460	14157	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	1274	10836	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
	3063228	10836	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
	CHEMBL1196470	10836	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
	1274	10836	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activityAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activity	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
	3063228	10836	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activityAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activity	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
	CHEMBL1196470	10836	16	None	7	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activityAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-induced cAMP-mediated CRE-beta galactosidase activity	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
	136141537	63255	3	None	-5	3	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632412	63255	3	None	-5	3	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayAgonist activity at rat histamine H4 receptor by luciferase reporter gene assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
	11313837	9278	8	None	-15848	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	1254	9278	8	None	-15848	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	CHEMBL175782	9278	8	None	-15848	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
	10583206	116137	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL321920	116137	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	1204	8713	119	None	-151	11	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	8713	119	None	-151	11	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	8713	119	None	-151	11	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	8713	119	None	-151	11	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	8713	119	None	-151	11	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	8713	119	None	-151	11	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	155513612	183099	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	-18	3	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	155512725	183020	0	None	-6	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4437371	183020	0	None	-6	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4594753	183020	0	None	-6	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
	58227163	183242	0	None	-4	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4518374	183242	0	None	-4	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596491	183242	0	None	-4	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	25130580	181081	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.6	CNc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	CHEMBL455016	181081	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	263	2	1	5	1.6	CNc1nc(N2CCN(C)CC2)cc(C(C)(C)C)n1	10.1021/jm8005959
	25129878	194114	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	324	3	1	7	1.4	COc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL493103	194114	0	None	-	1	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	324	3	1	7	1.4	COc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	127052295	146975	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	352	7	3	4	2.4	N#C/N=C(/NCCOc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3804862	146975	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	352	7	3	4	2.4	N#C/N=C(/NCCOc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	1204	8713	119	None	-288	11	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	8713	119	None	-288	11	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	8713	119	None	-288	11	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	8713	119	None	-288	11	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	8713	119	None	-288	11	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	8713	119	None	-288	11	Rat	4.3	pEC50	=	4.3	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	53233803	68296	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770962	68296	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
	25129169	193960	0	None	-1	2	Rat	7.3	pEC50	=	7.3	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	CHEMBL492231	193960	0	None	-1	2	Rat	7.3	pEC50	=	7.3	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
	127049856	147023	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	CHEMBL3805431	147023	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assayAgonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
	90667238	116253	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	220	4	3	3	0.3	CN/C(=N/C#N)NCCCc1c[nH]c(C)n1	10.1039/C3MD00245D
	CHEMBL3220639	116253	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation countingAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting	ChEMBL	220	4	3	3	0.3	CN/C(=N/C#N)NCCCc1c[nH]c(C)n1	10.1039/C3MD00245D
	565544	116520	11	None	-4466	2	Human	6.3	pEC50	=	6.3	Functional	Inhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptor	ChEMBL	125	2	2	2	0.5	CC(CN)c1cnc[nH]1	10.1021/jm0300025
	CHEMBL322988	116520	11	None	-4466	2	Human	6.3	pEC50	=	6.3	Functional	Inhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production for human Histamine H4 receptor	ChEMBL	125	2	2	2	0.5	CC(CN)c1cnc[nH]1	10.1021/jm0300025
	10583206	116137	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL321920	116137	0	None	-6	2	Human	5.3	pEC50	=	5.3	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	25130915	194067	1	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	CHEMBL492885	194067	1	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	283	2	1	5	1.8	Cc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1021/jm8005959
	46228125	206767	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL595215	206767	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	44482028	12396	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccn1	10.1021/jm900526h
	CHEMBL1077580	12396	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	325	9	3	4	1.8	N#C/N=C(/NCCCCc1c[nH]cn1)NCCCc1ccccn1	10.1021/jm900526h
	25131232	194069	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	308	2	1	6	1.7	Cc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL492900	194069	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	308	2	1	6	1.7	Cc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	25130235	194366	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	194366	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	25130235	194366	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	CHEMBL494678	194366	1	None	-4	3	Rat	7.2	pEC50	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
	45257133	206683	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL594721	206683	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	25128824	199957	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	CHEMBL523225	199957	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
	155517880	183446	0	None	-2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4445423	183446	0	None	-2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4598198	183446	0	None	-2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
	45269820	202128	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
	CHEMBL1202326	202128	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
	CHEMBL551790	202128	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assayAgonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
	25071004	199497	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL521996	199497	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	46890022	13818	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	8	3	4	4.3	Cc1cc(OCCCNCC2CCCNC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084869	13818	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	410	8	3	4	4.3	Cc1cc(OCCCNCC2CCCNC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46228158	208937	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL609289	208937	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	46890547	13288	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082772	13288	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
	1255	9969	19	None	-19	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
	6421522	9969	19	None	-19	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL19173	9969	19	None	-19	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
	9974306	211253	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL72372	211253	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
	10060212	211313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	CHEMBL72769	211313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
	136192874	63257	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632414	63257	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse histamine H4 receptor by luciferase reporter gene assayAgonist activity at mouse histamine H4 receptor by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	1236	8848	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	1237	8848	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	156615	8848	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	CHEMBL268229	8848	25	None	-549	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
	25129175	194158	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL493477	194158	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	223	2	1	6	-0.2	COc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	25130914	194033	0	None	15	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492677	194033	0	None	15	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25130908	178630	2	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	CHEMBL446896	178630	2	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	207	1	1	5	0.1	Cc1cnc(N)nc1N1CCN(C)CC1	10.1021/jm8005959
	24797775	194024	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492631	194024	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2cc(C(C)(C)C)nc(N)n2)CC1	10.1021/jm8005959
	1204	8713	119	None	-151	11	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	8713	119	None	-151	11	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	8713	119	None	-151	11	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	8713	119	None	-151	11	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	8713	119	None	-151	11	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	8713	119	None	-151	11	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	25130912	195518	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL505061	195518	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1021/jm8005959
	1204	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R by [35S]-GTPgammaS-binding assayAgonist activity at human H4R by [35S]-GTPgammaS-binding assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	25149521	185831	0	None	9	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL471413	185831	0	None	9	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.10.041
	1204	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	1247	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	1375	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	774	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	CHEMBL90	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	DB05381	8713	119	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2015.12.035
	1267	10576	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	3035905	10576	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	CHEMBL260374	10576	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	1269	6909	41	None	35	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	37463	6909	41	None	35	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	CHEMBL275443	6909	41	None	35	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	1267	10576	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	3035905	10576	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	CHEMBL260374	10576	49	None	-17	5	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingInverse agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	44482031	12414	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	234	6	3	3	0.8	CCN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077756	12414	1	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	234	6	3	3	0.8	CCN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	46890019	14084	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086085	14084	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAgonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	156015638	185051	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4642520	185051	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4650832	185051	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	1278	8931	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	1279	8931	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	4908365	8931	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	CHEMBL129198	8931	84	None	-1	4	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat H4R by [35S]-GTPgammaS-binding assayAgonist activity at rat H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	10978141	11922	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	CHEMBL105803	11922	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
	58227127	123907	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393543	123907	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
	44481489	12485	0	None	18	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(\NCCCc1ccccc1)NCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1078210	12485	0	None	18	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	310	8	3	3	2.0	N#C/N=C(\NCCCc1ccccc1)NCCCc1c[nH]cn1	10.1021/jm900526h
	10419556	12130	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL106913	12130	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	11086114	14166	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL108649	14166	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10820930	12571	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL107877	12571	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10106063	116048	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL321860	116048	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
	10106063	116048	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
	CHEMBL321860	116048	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 6 hrs by CRE/beta-galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
	56954318	88853	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	444	13	6	4	0.1	N/C(=N\C(=O)CCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165640	88853	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	444	13	6	4	0.1	N/C(=N\C(=O)CCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	10106063	116048	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL321860	116048	10	None	40	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	10017000	211264	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
	CHEMBL72431	211264	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
	1204	8713	119	None	-3	11	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	8713	119	None	-3	11	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	8713	119	None	-3	11	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	8713	119	None	-3	11	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	8713	119	None	-3	11	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	8713	119	None	-3	11	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	136192874	63257	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	CHEMBL1632414	63257	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assayAgonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
	1267	10576	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayInverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
	3035905	10576	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayInverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
	CHEMBL260374	10576	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assayInverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
	1239	8814	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1240	8814	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	912	8814	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL268490	8814	24	None	-1995	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	10978141	11922	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	CHEMBL105803	11922	1	None	-7	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
	1278	8931	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	1279	8931	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	4908365	8931	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	CHEMBL129198	8931	84	None	-1	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.9b01342
	42625303	187545	0	None	-501	6	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	CHEMBL475621	187545	0	None	-501	6	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/acs.jmedchem.9b01342
	10419556	12130	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL106913	12130	0	None	-9	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	11086114	14166	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	CHEMBL108649	14166	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
	155513612	183099	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4439142	183099	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4515149	183099	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	CHEMBL4595327	183099	0	None	-14	3	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
	25130230	179235	2	None	-3	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL448085	179235	2	None	-3	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	259	2	1	7	-0.0	CN1CCN(c2cc(-n3ccnc3)nc(N)n2)CC1	10.1021/jm8005959
	25133971	194128	2	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2nc(N)cc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	CHEMBL493261	194128	2	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	249	1	1	5	1.1	CN1CCN(c2nc(N)cc(C(C)(C)C)n2)CC1	10.1021/jm8005959
	25130229	195534	7	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	271	2	1	7	0.3	CN1CCN(c2cc(-c3cncnc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL505346	195534	7	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	271	2	1	7	0.3	CN1CCN(c2cc(-c3cncnc3)nc(N)n2)CC1	10.1021/jm8005959
	56954515	88840	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	546	17	6	6	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165628	88840	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	546	17	6	6	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm201128q
	56954322	88855	0	None	-4	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	500	17	6	4	1.7	N/C(=N\C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	CHEMBL2165642	88855	0	None	-4	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assayAgonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay	ChEMBL	500	17	6	4	1.7	N/C(=N\C(=O)CCCCCCCCC(=O)/N=C(\N)NCCCc1c[nH]cn1)NCCCc1c[nH]cn1	10.1021/jm201128q
	45257131	206687	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	CHEMBL594731	206687	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
	11846298	146059	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
	CHEMBL379102	146059	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Activity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assayActivity at human histamine H4 receptor transfected in SK-N-MC cells by cAMP assay	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
	25129176	179540	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2nc(N)ncc2-c2ccccc2)CC1	10.1021/jm8005959
	CHEMBL451108	179540	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	269	2	1	5	1.5	CN1CCN(c2nc(N)ncc2-c2ccccc2)CC1	10.1021/jm8005959
	58227388	123902	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393538	123902	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	1223	7740	41	None	-812	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	2790	7740	41	None	-812	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	CHEMBL14690	7740	41	None	-812	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.9b01342
	10820929	114984	1	None	-30	2	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	CHEMBL319658	114984	1	None	-30	2	Human	4.1	pEC50	=	4.1	Functional	Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptorInhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
	53233801	68319	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770985	68319	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrsAgonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
	58227252	123908	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393544	123908	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
	1204	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1204	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1247	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1247	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1375	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	1375	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	774	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	774	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	CHEMBL90	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	CHEMBL90	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	DB05381	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
	DB05381	8713	119	None	-151	11	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
	1274	10836	16	None	-199	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	3063228	10836	16	None	-199	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	CHEMBL1196470	10836	16	None	-199	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse H4R by [35S]-GTPgammaS-binding assayAgonist activity at mouse H4R by [35S]-GTPgammaS-binding assay	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/acs.jmedchem.9b01342
	25130236	194480	0	None	-1	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	CHEMBL495265	194480	0	None	-1	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	268	1	0	4	2.2	CN1CCN(c2cc(C(C)(C)C)nc(Cl)n2)CC1	10.1021/jm8005959
	1267	10576	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	3035905	10576	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	CHEMBL260374	10576	49	None	-17	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
	25129877	176239	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(I)c3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL442865	176239	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	395	2	1	5	2.1	CN1CCN(c2cc(-c3cccc(I)c3)nc(N)n2)CC1	10.1021/jm8005959
	44568847	194028	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	6	2.0	CN1CCN(c2cc(Sc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL492652	194028	0	None	-	1	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	301	3	1	6	2.0	CN1CCN(c2cc(Sc3ccccc3)nc(N)n2)CC1	10.1021/jm8005959
	25101945	199885	0	None	1	2	Mouse	8.0	pEC50	=	8.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL522673	199885	0	None	1	2	Mouse	8.0	pEC50	=	8.0	Functional	Antagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at mouse histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	25101945	199885	0	None	-1	2	Rat	8.0	pEC50	=	8.0	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	CHEMBL522673	199885	0	None	-1	2	Rat	8.0	pEC50	=	8.0	Functional	Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assayAntagonist activity at rat histamine H4 receptor expressed in HEK293 cells assessed as inhibition of histamine-induced intracellular calcium elevation by FLIPR assay	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
	58227143	123905	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393541	123905	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activityAgonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
	16061961	206458	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	CHEMBL593103	206458	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
	112936251	144044	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
	CHEMBL3752085	144044	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
	58227163	183242	0	None	-8	3	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4518374	183242	0	None	-8	3	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	CHEMBL4596491	183242	0	None	-8	3	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayAgonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
	25131556	195650	7	None	-3	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	CHEMBL507063	195650	7	None	-3	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	300	3	1	7	0.9	COc1ncccc1-c1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm8005959
	25128830	194492	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	234	1	0	4	1.5	CN1CCN(c2cc(C(C)(C)C)ncn2)CC1	10.1021/jm8005959
	CHEMBL495342	194492	0	None	-	1	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	234	1	0	4	1.5	CN1CCN(c2cc(C(C)(C)C)ncn2)CC1	10.1021/jm8005959
	127035835	144063	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	CHEMBL3752270	144063	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation countingAntagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
	11983344	12449	5	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	220	5	3	3	0.4	CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	CHEMBL1077862	12449	5	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayAgonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay	ChEMBL	220	5	3	3	0.4	CN/C(=N\C#N)NCCCCc1c[nH]cn1	10.1021/jm900526h
	25128829	194113	0	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	265	5	1	5	1.7	CN(C)CCCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	CHEMBL493100	194113	0	None	-	1	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assayAgonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay	ChEMBL	265	5	1	5	1.7	CN(C)CCCN(C)c1cc(C(C)(C)C)nc(N)n1	10.1021/jm8005959
	24745335	7083	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	7083	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	7083	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	7083	12	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	24745335	7083	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	7083	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	7083	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	7083	12	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	156013896	185019	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4635634	185019	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4650570	185019	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	44129134	206287	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	CHEMBL591969	206287	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	56835171	76515	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935574	76515	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	16082828	87035	0	None	-6	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	CHEMBL213886	87035	0	None	-6	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	71525678	96500	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376800	96500	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	71525679	96501	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376801	96501	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
	1278	8931	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	1279	8931	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	4908365	8931	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	CHEMBL129198	8931	84	None	1	4	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
	10446295	8913	34	None	11	2	Human	6.9	pIC50	=	6.9	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	1277	8913	34	None	11	2	Human	6.9	pIC50	=	6.9	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	CHEMBL185951	8913	34	None	11	2	Human	6.9	pIC50	=	6.9	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	155563181	182082	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	498	12	1	7	5.1	CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCCN2CCCCC2)cc1	10.1021/acs.jmedchem.9b00937
	CHEMBL4573309	182082	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	498	12	1	7	5.1	CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCCN2CCCCC2)cc1	10.1021/acs.jmedchem.9b00937
	25147771	181017	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	CHEMBL454890	181017	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	16082833	87122	0	None	-40	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
	CHEMBL214312	87122	0	None	-40	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
	90645145	118955	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	CHEMBL3290578	118955	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	1267	10576	49	None	-17	5	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.9b00937
	3035905	10576	49	None	-17	5	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.9b00937
	CHEMBL260374	10576	49	None	-17	5	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assayAntagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.9b00937
	1278	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1278	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	1279	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	4908365	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	CHEMBL129198	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assayAntagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proximity assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
	3201696	22541	4	None	-22	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human histamine H4 receptorAntagonist activity at human histamine H4 receptor	ChEMBL	348	5	0	6	2.1	CN1CCN(C(c2ccccc2)c2nnnn2Cc2ccccc2)CC1	10.1016/j.bmcl.2010.07.009
	CHEMBL1222728	22541	4	None	-22	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human histamine H4 receptorAntagonist activity at human histamine H4 receptor	ChEMBL	348	5	0	6	2.1	CN1CCN(C(c2ccccc2)c2nnnn2Cc2ccccc2)CC1	10.1016/j.bmcl.2010.07.009
	1278	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	8931	84	None	1	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	63868328	181030	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
	CHEMBL4549015	181030	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
	71548412	8690	20	None	14	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	9879	8690	20	None	14	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	CHEMBL4790724	8690	20	None	14	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	16656871	14748	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1090531	14748	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	16718567	14934	0	None	3311	2	Human	8.5	pIC50	=	8.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1091874	14934	0	None	3311	2	Human	8.5	pIC50	=	8.5	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	1278	8931	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	8931	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	8931	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	8931	84	None	1	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayAntagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	155540438	179320	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
	CHEMBL4483783	179320	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assayAntagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-induced intracellular calcium flux preincubated for 30 mins followed by histamine addition and measured for 30 secs in presence of coelenterazine by luminescence assay	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
	44129130	206335	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	CHEMBL592379	206335	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
	11682208	15046	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
	CHEMBL1092542	15046	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
	25112105	14935	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1091875	14935	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	24745335	7083	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	7083	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	7083	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	7083	12	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	1278	8931	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	1279	8931	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	4908365	8931	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	CHEMBL129198	8931	84	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Inhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptorInhibition of mouse bone-marrow mast cell chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	16656872	14684	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1090190	14684	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	122193095	130692	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
	CHEMBL3628042	130692	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
	49841846	76513	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935572	76513	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	49841719	76512	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935571	76512	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	1278	8931	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	8931	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	8931	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	8931	84	None	1	4	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationAntagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	90645147	118953	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	CHEMBL3290576	118953	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassayAntagonist activity at human histamine H4 receptor expressed in gamma-irradiated recombinant CHO cells assessed as inhibition of forskolin/histamine-induced intracellular cAMP accumulation preincubated for 30 mins followed by Eu chelate-labeled cAMP/anti-cAMP mAb addition measured after 1 hr by TR-FRET immunoassay	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
	24745335	7083	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	8985	7083	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	CHEMBL1915540	7083	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	DB15027	7083	12	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
	10446295	8913	34	None	11	2	Human	6.3	pIC50	=	6.3	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	1277	8913	34	None	11	2	Human	6.3	pIC50	=	6.3	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	CHEMBL185951	8913	34	None	11	2	Human	6.3	pIC50	=	6.3	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	122194625	130799	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
	CHEMBL3629828	130799	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassayAntagonist activity at human H4R expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by TR-FRET immunoassay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
	1267	10576	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assayAntagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.09.061
	3035905	10576	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assayAntagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.09.061
	CHEMBL260374	10576	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assayAntagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamine-induced cAMP accumulation after 5 hrs by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.09.061
	1267	10576	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
	3035905	10576	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
	CHEMBL260374	10576	49	None	-17	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
	25147772	180188	9	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	CHEMBL452847	180188	9	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayInverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assay	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
	71548412	8690	20	None	-14	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	9879	8690	20	None	-14	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	CHEMBL4790724	8690	20	None	-14	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assayAntagonist activity at recombinant mouse histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced stimulation of [35S]-GTPgammaS binding by scintillation proximity assay	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
	11709443	15018	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
	CHEMBL1092332	15018	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
	71519674	96504	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376804	96504	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	16656874	14878	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	CHEMBL1091569	14878	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assayInverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
	49841845	76514	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935573	76514	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	156013896	185019	0	None	-38	3	Mouse	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4635634	185019	0	None	-38	3	Mouse	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	CHEMBL4650570	185019	0	None	-38	3	Mouse	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assayInverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskolin stimulated luciferase activity by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
	1278	8931	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	1279	8931	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	4908365	8931	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	CHEMBL129198	8931	84	None	1	4	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human eosinophil chemotaxis mediated by histamine H4 receptorInhibition of human eosinophil chemotaxis mediated by histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	16082831	87121	0	None	-100	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	CHEMBL214311	87121	0	None	-100	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	71525681	96503	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	CHEMBL2376803	96503	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human histamine H4 receptor expressed in HEK cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
	1267	10576	49	None	-17	5	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	3035905	10576	49	None	-17	5	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	CHEMBL260374	10576	49	None	-17	5	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	58227148	123911	0	None	-	1	Human	10.1	pKd	=	10.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393547	123911	0	None	-	1	Human	10.1	pKd	=	10.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	59777258	116910	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
	CHEMBL3236561	116910	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
	24797604	116901	2	None	-	0	Human	9.9	pKd	=	9.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
	CHEMBL3236552	116901	2	None	-	0	Human	9.9	pKd	=	9.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
	24994542	116903	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236554	116903	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
	24798144	116902	2	None	-	1	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	CHEMBL3236553	116902	2	None	-	1	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	53257796	116924	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236575	116924	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
	54587790	68314	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770980	68314	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	24745337	68313	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770979	68313	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	59777338	116905	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
	CHEMBL3236556	116905	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
	44547268	123890	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393526	123890	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	58227340	123896	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393532	123896	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	58227200	123899	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393535	123899	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	54585781	68335	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	CHEMBL1771000	68335	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
	54583873	68303	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770969	68303	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	54587787	68305	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770971	68305	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
	54581940	68326	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770992	68326	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	25130912	195518	0	None	-	1	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL505061	195518	0	None	-	1	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
	23653543	74823	2	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	CHEMBL1914541	74823	2	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	24994636	116914	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
	CHEMBL3236565	116914	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
	42624149	116917	1	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236568	116917	1	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	59777262	116921	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236572	116921	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
	54584824	68311	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770977	68311	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	58227337	123917	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393553	123917	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	58227259	123920	0	None	-	1	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393556	123920	0	None	-	1	Human	8.0	pKd	=	8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	24798144	116902	2	None	-	1	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	CHEMBL3236553	116902	2	None	-	1	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
	24826766	74876	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	CHEMBL1914750	74876	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	9944571	123795	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL338937	123795	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	24994634	8923	31	None	-	1	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	8984	8923	31	None	-	1	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	CHEMBL3236549	8923	31	None	-	1	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	53258370	116918	1	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236569	116918	1	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	24994635	116919	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236570	116919	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
	54582865	68293	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770959	68293	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
	54584825	68324	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770990	68324	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
	11587279	131829	4	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL364400	131829	4	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
	46890627	13361	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1083098	13361	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	66740470	116575	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
	CHEMBL3233048	116575	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
	11687917	21737	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
	CHEMBL120854	21737	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
	9966927	25647	5	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128252	25647	5	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
	54581938	68306	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770972	68306	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
	67087450	123914	0	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393550	123914	0	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	11594278	21462	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	CHEMBL120591	21462	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	9923162	25712	6	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128613	25712	6	None	-	1	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
	11120826	25690	1	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128505	25690	1	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
	46890677	14063	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086038	14063	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46890166	14088	0	None	-3	4	Mouse	4.8	pKd	=	4.8	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086105	14088	0	None	-3	4	Mouse	4.8	pKd	=	4.8	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	66740898	116911	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
	CHEMBL3236562	116911	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
	10468601	202370	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activityAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activity	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
	CHEMBL1202324	202370	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activityAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activity	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
	CHEMBL555434	202370	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activityAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of 2-[3-(imidazol-4-yl)-propyl]-1-(4-iodo-benzyl)-isothiourea dihydrobromide-induced intrinsic activity	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
	53233904	68299	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770965	68299	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
	10446295	8913	34	None	11	2	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	1277	8913	34	None	11	2	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	CHEMBL185951	8913	34	None	11	2	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
	4242975	25614	9	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	CHEMBL128088	25614	9	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	9900313	26196	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129444	26196	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
	9839217	79294	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	CHEMBL199062	79294	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	11565330	103995	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
	CHEMBL268525	103995	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
	4906599	175441	11	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL436381	175441	11	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	24996854	116913	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
	CHEMBL3236564	116913	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
	42624150	116926	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236577	116926	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
	24797956	116907	3	None	-	1	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
	CHEMBL3236558	116907	3	None	-	1	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
	24992735	116932	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
	CHEMBL3236582	116932	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
	10244243	148091	3	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	CHEMBL383384	148091	3	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
	46890592	13164	0	None	-	2	Human	7.6	pKd	=	7.6	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082296	13164	0	None	-	2	Human	7.6	pKd	=	7.6	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	44547127	122696	0	None	-	1	Human	8.5	pKd	=	8.5	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3354816	122696	0	None	-	1	Human	8.5	pKd	=	8.5	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
	24992077	116920	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236571	116920	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	10934567	26030	1	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	CHEMBL129026	26030	1	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	11630326	79346	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	CHEMBL199231	79346	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
	44547567	123897	2	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393533	123897	2	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
	4060730	26151	56	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129199	26151	56	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
	53378711	116927	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236578	116927	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
	24994634	8923	31	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	8984	8923	31	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	CHEMBL3236549	8923	31	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	54753437	74958	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	CHEMBL1915048	74958	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
	42624149	116917	1	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	CHEMBL3236568	116917	1	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at mouse histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
	46890590	13796	0	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084810	13796	0	None	-	0	Mouse	7.3	pKd	=	7.3	Functional	Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challengeAntagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 mins before forskolin challenge	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	11572877	73854	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	CHEMBL187285	73854	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
	9992865	121204	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL333220	121204	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
	11601630	139595	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL370135	139595	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
	46890546	13287	0	None	-	1	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1082771	13287	0	None	-	1	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	46890590	13796	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1084810	13796	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	2063135	15150	9	None	-	1	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	CHEMBL1093180	15150	9	None	-	1	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at recombinant human histamine H4 receptorAntagonist activity at recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
	11066922	26195	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129436	26195	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
	24994634	8923	31	None	-	1	Rat	7.2	pKd	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	8984	8923	31	None	-	1	Rat	7.2	pKd	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	CHEMBL3236549	8923	31	None	-	1	Rat	7.2	pKd	=	7.2	Functional	Antagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at rat histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
	10083188	147712	3	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL382276	147712	3	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
	46890019	14084	0	None	-	1	Human	7.2	pKd	=	7.2	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	CHEMBL1086085	14084	0	None	-	1	Human	7.2	pKd	=	7.2	Functional	Intrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assayIntrinsic activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP responsive element-beta-galactosidase activity after 6 hrs by colorimetric cAMP assay	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
	1278	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	1279	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	4908365	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	CHEMBL129198	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
	10967174	26214	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
	CHEMBL129540	26214	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Decrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptorDecrease in the forskolin stimulatedcAMP levels was determined using SK-N-MC cells stably transfected with the human H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
	42624148	116923	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
	CHEMBL3236574	116923	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysisAntagonist activity at human histamine H4 receptor expressed in SK-N-MC cells assessed as reduction of histamine-induced inhibition of cAMP-mediated beta-galactosidase reporter gene activity treated 10 mins prior to histamine challenge by microplate reader analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
	54583875	68329	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	CHEMBL1770995	68329	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrsAntagonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 6 hrs	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
	58227179	123912	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393548	123912	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
	58227086	123921	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	CHEMBL3393557	123921	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
	1278	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	1279	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	4908365	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	CHEMBL129198	8931	84	None	1	4	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
	10967174	26214	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL129540	26214	3	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
	10988959	124886	4	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL340740	124886	4	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
	10923241	25937	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL128958	25937	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
	9878733	123622	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	CHEMBL338051	123622	1	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
	11623296	123801	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
	CHEMBL338972	123801	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activityAntagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
	16202258	74993	0	None	-	0	Human	10.5	pKi	=	10.5	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915536	74993	0	None	-	0	Human	10.5	pKi	=	10.5	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	24745506	74994	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915537	74994	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	24745335	7083	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	8985	7083	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	CHEMBL1915540	7083	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	DB15027	7083	12	None	-	1	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
	44187557	202278	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at histamine H4 receptorAgonistic activity at histamine H4 receptor	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm1013488
	CHEMBL1202332	202278	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at histamine H4 receptorAgonistic activity at histamine H4 receptor	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm1013488
	CHEMBL553423	202278	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at histamine H4 receptorAgonistic activity at histamine H4 receptor	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm1013488
	135525668	74987	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915348	74987	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	136042270	76690	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938979	76690	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	24745507	74995	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915538	74995	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
	57401167	76644	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938846	76644	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57400778	74985	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915346	74985	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	135525668	74987	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915348	74987	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57391926	76677	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938967	76677	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	136042269	76689	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938978	76689	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57402929	76642	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938844	76642	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57395538	74986	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915347	74986	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	136042267	76687	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938976	76687	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57400777	74984	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915345	74984	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	57400777	74984	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1915345	74984	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	49841846	76513	0	None	-	1	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935572	76513	0	None	-	1	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	11688307	76678	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938968	76678	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	54754351	74992	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
	CHEMBL1915535	74992	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
	57400778	74985	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915346	74985	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	10446295	8913	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
	1277	8913	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
	CHEMBL185951	8913	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
	10446295	8913	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
	1277	8913	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
	CHEMBL185951	8913	34	None	11	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
	49841719	76512	0	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935571	76512	0	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	57391927	76679	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938969	76679	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	1278	8931	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	1279	8931	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	4908365	8931	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	CHEMBL129198	8931	84	None	1	4	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	49841845	76514	0	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935573	76514	0	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
	57395538	74986	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915347	74986	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
	136042265	76685	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938974	76685	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	57395620	74991	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915534	74991	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
	57395620	74991	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
	CHEMBL1915534	74991	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
	1278	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1279	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	4908365	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	CHEMBL129198	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
	1278	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	1279	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	4908365	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	CHEMBL129198	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor by functional assayAntagonist activity at human histamine H4 receptor by functional assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
	1278	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	1279	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	4908365	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	CHEMBL129198	8931	84	None	1	4	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
	1267	10576	49	None	-17	5	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	3035905	10576	49	None	-17	5	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	CHEMBL260374	10576	49	None	-17	5	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
	56835171	76515	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	CHEMBL1935574	76515	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingAntagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
	57390145	76681	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938970	76681	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
	136042268	76688	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	CHEMBL1938977	76688	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
	136042266	76686	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	CHEMBL1938975	76686	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	54754351	74992	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
	CHEMBL1915535	74992	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assayAntagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamase reporter gene assay	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
	56950378	76643	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	CHEMBL1938845	76643	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assayAntagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by CRE-betalactamase reporter gene assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
	135	9310	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	9310	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	9310	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	9310	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	9310	43	None	-2	33	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1225	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	5344	180252	101	None	60	6	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	None
	CHEMBL453	180252	101	None	60	6	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	None
	1272	7618	0	None	-	1	Human	8.1	pIC50	None	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15265943

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		51354301	65666	0	None	-10	2	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
		CHEMBL1688969	65666	0	None	-10	2	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/acs.jmedchem.8b00435
		70692530	82466	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
		CHEMBL2047474	82466	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1021/acs.jmedchem.8b00435
		90667434	116266	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	2	3	1.9	CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220892	116266	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	2	3	1.9	CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1	10.1039/C3MD00245D
		44367568	52515	5	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@@H]2CCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL153051	52515	5	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@@H]2CCNC2)c[nH]1	10.1021/jm030905y
		9877454	212392	2	None	-4	2	Human	5.0	pEC50	=	5.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL81644	212392	2	None	-4	2	Human	5.0	pEC50	=	5.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		155512725	183020	0	None	-	2	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	183020	0	None	-	2	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	183020	0	None	-	2	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		1267	10576	49	None	-33	27	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm9000693
		3035905	10576	49	None	-33	27	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm9000693
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm9000693
		9793791	52792	3	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	137	2	2	2	0.5	NCC1CC1c1c[nH]cn1	10.1021/jm030905y
		CHEMBL153284	52792	3	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	137	2	2	2	0.5	NCC1CC1c1c[nH]cn1	10.1021/jm030905y
		155524115	183326	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	183326	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	183326	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		1204	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1247	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1375	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		774	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		DB05381	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1236	8848	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		1237	8848	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		156615	8848	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		CHEMBL268229	8848	25	None	-204	7	Human	6.0	pEC50	=	6.0	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm030905y
		46890592	13164	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082296	13164	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		46890166	14088	0	None	-4786	2	Mouse	7.9	pEC50	=	7.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086105	14088	0	None	-4786	2	Mouse	7.9	pEC50	=	7.9	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		1204	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1247	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1375	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		774	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		DB05381	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1204	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1247	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1375	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		774	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		DB05381	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1278	8931	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		1279	8931	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		4908365	8931	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitmentAgonist activity at histamine H4 receptor (unknown origin) assessed as increase in beta-arrestin recruitment	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.8b00435
		155524115	183326	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	183326	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	183326	0	None	1	3	Mouse	7.9	pEC50	=	7.9	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		11344458	211977	2	None	-14	2	Human	5.9	pEC50	=	5.9	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78497	211977	2	None	-14	2	Human	5.9	pEC50	=	5.9	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		1204	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1247	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1375	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		774	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		DB05381	8713	119	None	-3	25	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		24797956	116907	3	None	-	1	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human H4 receptorAgonist activity at human H4 receptor	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		CHEMBL3236558	116907	3	None	-	1	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human H4 receptorAgonist activity at human H4 receptor	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		58227373	183287	0	None	-	2	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	183287	0	None	-	2	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	183287	0	None	-	2	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		155552061	183257	0	None	38	2	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	183257	0	None	38	2	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	183257	0	None	38	2	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		46887115	15283	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)C[C@H](C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1094144	15283	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)C[C@H](C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		58227373	183287	0	None	1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	183287	0	None	1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	183287	0	None	1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		155517880	183446	0	None	-	2	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	183446	0	None	-	2	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	183446	0	None	-	2	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		25149335	191004	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9000693
		CHEMBL483406	191004	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9000693
		25149335	191004	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL483406	191004	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1039/C3MD00245D
		25149335	191004	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm800841w
		CHEMBL483406	191004	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm800841w
		45267230	203261	0	None	-1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL1202318	203261	0	None	-1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL563342	203261	0	None	-1	2	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		42625223	186704	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	395	8	4	3	1.4	CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm9000693
		CHEMBL474617	186704	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	395	8	4	3	1.4	CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm9000693
		11240759	111990	5	None	-190	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL311473	111990	5	None	-190	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		9812843	212023	1	None	-4	2	Human	4.8	pEC50	=	4.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78838	212023	1	None	-4	2	Human	4.8	pEC50	=	4.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		11469514	110945	2	None	-64	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL309654	110945	2	None	-64	2	Human	5.8	pEC50	=	5.8	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		155524115	183326	0	None	-	3	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	183326	0	None	-	3	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	183326	0	None	-	3	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		127052293	147016	3	None	-	4	Mouse	6.8	pEC50	=	6.8	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	147016	3	None	-	4	Mouse	6.8	pEC50	=	6.8	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		155513612	183099	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		42626109	186547	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	324	6	4	2	1.5	N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL474447	186547	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	324	6	4	2	1.5	N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		155512725	183020	0	None	-	2	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	183020	0	None	-	2	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	183020	0	None	-	2	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		42625386	185132	0	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL465170	185132	0	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		46830167	15533	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096429	15533	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		11171320	52702	5	None	-	1	Human	5.7	pEC50	=	5.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	179	3	2	2	1.3	c1nc(CCC2CCCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL153207	52702	5	None	-	1	Human	5.7	pEC50	=	5.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	179	3	2	2	1.3	c1nc(CCC2CCCNC2)c[nH]1	10.1021/jm030905y
		170389	213760	35	None	1	3	Human	6.7	pEC50	=	6.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/jm030905y
		CHEMBL4634086	213760	35	None	1	3	Human	6.7	pEC50	=	6.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/jm030905y
		CHEMBL91353	213760	35	None	1	3	Human	6.7	pEC50	=	6.7	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/jm030905y
		46887041	15532	1	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096428	15532	1	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		155517880	183446	0	None	-	2	Mouse	6.6	pEC50	=	6.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	183446	0	None	-	2	Mouse	6.6	pEC50	=	6.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	183446	0	None	-	2	Mouse	6.6	pEC50	=	6.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		1204	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	8713	119	None	-15	25	Mouse	5.6	pEC50	=	5.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		127052293	147016	3	None	34	4	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	147016	3	None	34	4	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11301441	102929	10	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/acs.jmedchem.8b00435
		CHEMBL260549	102929	10	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/acs.jmedchem.8b00435
		1278	8931	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		1279	8931	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		4908365	8931	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		CHEMBL129198	8931	84	None	-3	8	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assayAgonist activity at human H4R expressed in human U2OS cells assessed as recruitment of beta-arrestin after 2 hrs by PathHunter beta-galactosidase enzyme fragment complementation assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401677g
		58227401	183230	0	None	-	2	Mouse	7.6	pEC50	=	7.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	183230	0	None	-	2	Mouse	7.6	pEC50	=	7.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	183230	0	None	-	2	Mouse	7.6	pEC50	=	7.6	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-2	4	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		42625222	186549	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	367	7	5	3	0.7	N/C(=N\C(=O)CNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL474449	186549	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	367	7	5	3	0.7	N/C(=N\C(=O)CNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		1267	10576	49	None	-21	27	Mouse	7.6	pEC50	=	7.6	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-21	27	Mouse	7.6	pEC50	=	7.6	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-21	27	Mouse	7.6	pEC50	=	7.6	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		90667228	116246	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220629	116246	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1ccccc1	10.1039/C3MD00245D
		58227401	183230	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	183230	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	183230	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		42625303	187545	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL475621	187545	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		42625304	185879	0	None	-	1	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL471724	185879	0	None	-	1	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		11286909	212063	2	None	-1	2	Human	5.5	pEC50	=	5.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL79126	212063	2	None	-1	2	Human	5.5	pEC50	=	5.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		9964223	212466	11	None	-36	2	Human	4.5	pEC50	=	4.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL82244	212466	11	None	-36	2	Human	4.5	pEC50	=	4.5	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		42626111	196473	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	381	8	5	3	1.1	N/C(=N\C(=O)CCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL515428	196473	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	381	8	5	3	1.1	N/C(=N\C(=O)CCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		1204	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	8713	119	None	-3	25	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		58227373	183287	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	183287	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	183287	0	None	-	2	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		155552061	183257	0	None	-	2	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	183257	0	None	-	2	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	183257	0	None	-	2	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		58227163	183242	0	None	-	2	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	183242	0	None	-	2	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	183242	0	None	-	2	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		127050776	147025	0	None	-	2	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805437	147025	0	None	-	2	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1204	8713	119	None	-12	25	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	8713	119	None	-12	25	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	8713	119	None	-12	25	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	8713	119	None	-12	25	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	8713	119	None	-12	25	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	8713	119	None	-12	25	Rat	5.4	pEC50	=	5.4	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		45269820	202128	0	None	-1	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL1202326	202128	0	None	-1	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		CHEMBL551790	202128	0	None	-1	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1021/acs.jmedchem.8b00435
		155512725	183020	0	None	154	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	183020	0	None	154	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	183020	0	None	154	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		16078981	50847	12	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	c1nc(CC2CCCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL151467	50847	12	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	c1nc(CC2CCCNC2)c[nH]1	10.1021/jm030905y
		155524115	183326	0	None	-2	3	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	183326	0	None	-2	3	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	183326	0	None	-2	3	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		46887043	15535	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096431	15535	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		42625384	176552	0	None	-	1	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL443896	176552	0	None	-	1	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		44367567	175980	3	None	-	1	Human	6.4	pEC50	=	6.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@H]2CCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL440730	175980	3	None	-	1	Human	6.4	pEC50	=	6.4	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(C[C@H]2CCNC2)c[nH]1	10.1021/jm030905y
		58227163	183242	0	None	40	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	183242	0	None	40	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	183242	0	None	40	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assayAgonist activity at mouse recombinant H4R expressed in HEK293T cells by beta-arrestin recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		156013896	185019	0	None	-22	4	Mouse	7.3	pEC50	=	7.3	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.3	pEC50	=	7.3	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.3	pEC50	=	7.3	Binding	Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assayAntagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment preincubated for 15 mins followed by histamine addition by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		127049855	147006	0	None	-1	4	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	147006	0	None	-1	4	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11957573	8791	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		1250	8791	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		3692	8791	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		CHEMBL19439	8791	34	None	-40	6	Human	7.3	pEC50	=	7.3	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm020415q
		155513612	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		127051301	146978	0	None	-	2	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	146978	0	None	-	2	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1204	8713	119	None	-3	25	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1247	8713	119	None	-3	25	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1375	8713	119	None	-3	25	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		774	8713	119	None	-3	25	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		CHEMBL90	8713	119	None	-3	25	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		DB05381	8713	119	None	-3	25	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		46235428	13376	0	None	-	1	Mouse	6.3	pEC50	=	6.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083162	13376	0	None	-	1	Mouse	6.3	pEC50	=	6.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		1251	8795	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		3035842	8795	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		CHEMBL18661	8795	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		1251	8795	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm030905y
		3035842	8795	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm030905y
		CHEMBL18661	8795	39	None	-100	5	Human	7.3	pEC50	=	7.3	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm030905y
		11206058	111192	9	None	-10	2	Human	4.2	pEC50	=	4.2	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL310360	111192	9	None	-10	2	Human	4.2	pEC50	=	4.2	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		127049855	147006	0	None	-	4	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	147006	0	None	-	4	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		25149708	195215	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	319	7	4	4	2.2	CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)c1cccs1	10.1021/jm800841w
		CHEMBL502339	195215	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	319	7	4	4	2.2	CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)c1cccs1	10.1021/jm800841w
		58227401	183230	0	None	7	2	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	183230	0	None	7	2	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	183230	0	None	7	2	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		46887079	15281	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)CC(C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1094142	15281	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	365	7	4	5	3.2	Cc1nc(N)sc1CCCNC(=N)NC(=O)CC(C)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		127051301	146978	0	None	5	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	146978	0	None	5	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		25130914	194033	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
		CHEMBL492677	194033	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assayAgonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1021/acs.jmedchem.8b00435
		156015638	185051	0	None	-58	4	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	185051	0	None	-58	4	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	185051	0	None	-58	4	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assayAgonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		58227163	183242	0	None	-	2	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	183242	0	None	-	2	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	183242	0	None	-	2	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayAgonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		25149613	185979	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	382	8	4	5	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1	10.1021/jm800841w
		CHEMBL472441	185979	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	382	8	4	5	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1	10.1021/jm800841w
		136773074	164144	0	None	-	1	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4077914	164144	0	None	-	1	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		42625221	196367	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	338	7	4	2	1.9	N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL514641	196367	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	338	7	4	2	1.9	N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
		24798144	116902	2	None	-19	3	Mouse	8.1	pEC50	=	8.1	Binding	Partial agonist activity at mouse histamine H4 receptorPartial agonist activity at mouse histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		CHEMBL3236553	116902	2	None	-19	3	Mouse	8.1	pEC50	=	8.1	Binding	Partial agonist activity at mouse histamine H4 receptorPartial agonist activity at mouse histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		10374457	35668	2	None	-	2	Human	5.2	pEC50	=	5.2	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	123	1	2	2	0.2	N[C@H]1C[C@@H]1c1c[nH]cn1	10.1021/jm030905y
		CHEMBL13795	35668	2	None	-	2	Human	5.2	pEC50	=	5.2	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	123	1	2	2	0.2	N[C@H]1C[C@@H]1c1c[nH]cn1	10.1021/jm030905y
		11819221	52534	3	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(CC2CCNC2)c[nH]1	10.1021/jm030905y
		CHEMBL153061	52534	3	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	151	2	2	2	0.6	c1nc(CC2CCNC2)c[nH]1	10.1021/jm030905y
		1204	8713	119	None	-3	25	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		1247	8713	119	None	-3	25	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		1375	8713	119	None	-3	25	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		774	8713	119	None	-3	25	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		CHEMBL90	8713	119	None	-3	25	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		DB05381	8713	119	None	-3	25	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Histamine H4 receptorInhibition of human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		90667229	116247	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	319	7	3	3	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1cccs1	10.1039/C3MD00245D
		CHEMBL3220630	116247	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	319	7	3	3	2.0	CC(CC(=O)/N=C(\N)NCCCc1ncc[nH]1)c1cccs1	10.1039/C3MD00245D
		11546127	102259	2	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL25725	102259	2	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		182527	117345	8	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	167	4	4	2	-0.2	N=C(N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL325327	117345	8	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	167	4	4	2	-0.2	N=C(N)NCCCc1c[nH]cn1	10.1021/jm9000693
		46887042	15534	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096430	15534	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		25149521	185831	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1021/jm800841w
		CHEMBL471413	185831	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assayActivity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1021/jm800841w
		155552061	183257	0	None	-	2	Mouse	6.1	pEC50	=	6.1	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	183257	0	None	-	2	Mouse	6.1	pEC50	=	6.1	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	183257	0	None	-	2	Mouse	6.1	pEC50	=	6.1	Binding	Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assayAgonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		155517880	183446	0	None	16	2	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	183446	0	None	16	2	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	183446	0	None	16	2	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assayAgonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		1249	8790	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		13499360	8790	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		CHEMBL90019	8790	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		1249	8790	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm030905y
		13499360	8790	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm030905y
		CHEMBL90019	8790	16	None	-3	3	Human	7.1	pEC50	=	7.1	Binding	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm030905y
		1204	8713	119	None	-3	25	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1247	8713	119	None	-3	25	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1375	8713	119	None	-3	25	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		774	8713	119	None	-3	25	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		CHEMBL90	8713	119	None	-3	25	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		DB05381	8713	119	None	-3	25	Human	8.0	pEC50	=	8.0	Binding	Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assayActivity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		4024	8796	20	None	-301	2	Human	6.0	pEC50	=	6.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		9989505	8796	20	None	-301	2	Human	6.0	pEC50	=	6.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		CHEMBL82298	8796	20	None	-301	2	Human	6.0	pEC50	=	6.0	Binding	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptorInhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		1204	8713	119	None	-15	25	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1247	8713	119	None	-15	25	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1375	8713	119	None	-15	25	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		774	8713	119	None	-15	25	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90	8713	119	None	-15	25	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		DB05381	8713	119	None	-15	25	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assayAgonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		16718567	14934	0	None	-	1	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091874	14934	0	None	-	1	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		46885297	15187	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	318	1	1	6	2.5	CN1CCN(c2nc(O)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093438	15187	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	318	1	1	6	2.5	CN1CCN(c2nc(O)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		17747460	68103	12	None	-	4	Human	5.0	pIC50	=	5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
		CHEMBL1767164	68103	12	None	-	4	Human	5.0	pIC50	=	5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
		46884945	15017	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	330	1	0	5	3.6	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CC(C)N1C	10.1016/j.bmcl.2010.02.097
		CHEMBL1092331	15017	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	330	1	0	5	3.6	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CC(C)N1C	10.1016/j.bmcl.2010.02.097
		71547931	189890	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3c3ncnn23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4794724	189890	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3c3ncnn23)C1	10.1021/acs.jmedchem.7b01855
		11335478	167744	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL4115693	167744	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		1224	8214	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	8214	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	8214	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	8214	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	8214	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	8214	83	None	-194	13	Human	5.0	pIC50	=	5.0	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		11709443	15018	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		CHEMBL1092332	15018	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	314	1	0	5	2.9	CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		71548405	188938	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	0	7	1.1	CN(C)C1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4782441	188938	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	0	7	1.1	CN(C)C1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		46884998	14749	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	1	1	5	2.6	NC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090532	14749	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	1	1	5	2.6	NC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		25112105	14935	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091875	14935	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		71547681	189724	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.7	Clc1cnc2nc(N3CCNCC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4792733	189724	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.7	Clc1cnc2nc(N3CCNCC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		46885128	14742	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.2	CNC1(C)CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090519	14742	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.2	CNC1(C)CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		46885129	14743	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	1	5	3.2	Clc1ccc2oc3c(N4CC5CCCNC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090520	14743	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	1	5	3.2	Clc1ccc2oc3c(N4CC5CCCNC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		46885241	15047	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	2	1	5	3.8	CN[C@@H]1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092543	15047	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	2	1	5	3.8	CN[C@@H]1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		156013896	185019	0	None	-7	4	Human	7.8	pIC50	=	7.8	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	7.8	pIC50	=	7.8	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	7.8	pIC50	=	7.8	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		16656869	14876	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.1	CNC1CCN(c2nc(C)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091559	14876	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	1	5	3.1	CNC1CCN(c2nc(C)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		124087	8171	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	8171	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	8171	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	8171	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	8171	114	None	-5888	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		11566111	15118	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1CC2CCC1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		CHEMBL1092933	15118	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1CC2CCC1CN2c1ncnc2c1oc1ccc(Cl)cc12	10.1016/j.bmcl.2010.02.097
		71547932	189546	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3c3ncnn23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4790239	189546	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3c3ncnn23)CC1	10.1021/acs.jmedchem.7b01855
		13680692	190213	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	313	2	0	8	0.9	CN1CCN(c2nc3ccc([N+](=O)[O-])cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4798729	190213	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	313	2	0	8	0.9	CN1CCN(c2nc3ccc([N+](=O)[O-])cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		46885239	14966	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092064	14966	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2010.02.097
		71547762	189498	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.7	CN1CCN(c2nc3nc(Cl)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4789645	189498	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.7	CN1CCN(c2nc3nc(Cl)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		2063135	15150	9	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093180	15150	9	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		11695388	15016	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.2	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CCN1C	10.1016/j.bmcl.2010.02.097
		CHEMBL1092330	15016	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.2	CC1CN(c2ncnc3c2oc2ccc(Cl)cc23)CCN1C	10.1016/j.bmcl.2010.02.097
		9904236	20848	22	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL1197564	20848	22	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46884997	14492	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	0	5	3.2	CN(C)C1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1088888	14492	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	2	0	5	3.2	CN(C)C1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		1530	8963	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-21379	21	Human	4.7	pIC50	=	4.7	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		20889070	188651	6	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	302	1	0	6	1.7	CN1CCN(c2nc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778864	188651	6	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	302	1	0	6	1.7	CN1CCN(c2nc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		820836	109718	10	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	268	1	0	6	1.0	CN1CCN(c2nc3ccccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL306316	109718	10	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	268	1	0	6	1.0	CN1CCN(c2nc3ccccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		121237834	154137	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL3929465	154137	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	ChEMBL	297	0	2	3	3.5	O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46884996	14769	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	Clc1ccc2oc3c(N4CCN5CCCC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090655	14769	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	Clc1ccc2oc3c(N4CCN5CCCC5C4)ncnc3c2c1	10.1016/j.bmcl.2010.02.097
		71548223	188639	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	401	3	0	8	2.0	CN1CCN(c2nc3nc(OCC(F)(F)F)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778712	188639	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	401	3	0	8	2.0	CN1CCN(c2nc3nc(OCC(F)(F)F)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71547685	189769	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	294	1	0	8	0.3	CN1CCN(c2nc3ncc(C#N)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4793425	189769	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	294	1	0	8	0.3	CN1CCN(c2nc3ncc(C#N)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71548412	8690	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		9879	8690	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		CHEMBL4790724	8690	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		71547764	189132	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	328	1	0	8	0.9	CN1CCN(c2nc3nc(C#N)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4784683	189132	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	328	1	0	8	0.9	CN1CCN(c2nc3nc(C#N)c(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71548498	189019	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	348	1	0	8	0.6	CN1CCN(c2nc3ncc(Br)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4783487	189019	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	348	1	0	8	0.6	CN1CCN(c2nc3ncc(Br)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71548031	189687	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.4	CN1CCN(c2nc3ncc(C(F)(F)F)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4792352	189687	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	337	1	0	7	1.4	CN1CCN(c2nc3ncc(C(F)(F)F)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		16656871	14748	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090531	14748	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		1278	8931	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		1279	8931	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		4908365	8931	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		CHEMBL129198	8931	84	None	-3	8	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.7b01855
		71548412	8690	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		9879	8690	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		CHEMBL4790724	8690	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant mouse histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	10.1021/acs.jmedchem.7b01855
		71548319	190017	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	CN1CCCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4796300	190017	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	CN1CCCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		46885178	14485	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	336	2	1	5	3.2	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1088859	14485	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	336	2	1	5	3.2	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2010.02.097
		71548224	189307	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	361	1	0	7	1.5	Cc1c(Br)cnc2nc(N3CCN(C)CC3)c3nncn3c12	10.1021/acs.jmedchem.7b01855
		CHEMBL4787243	189307	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	361	1	0	7	1.5	Cc1c(Br)cnc2nc(N3CCN(C)CC3)c3nncn3c12	10.1021/acs.jmedchem.7b01855
		71547599	188847	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3ncccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4781409	188847	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3ncccc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		71547680	189606	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3cccnc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4791152	189606	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	269	1	0	7	0.4	CN1CCN(c2nc3cccnc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		11709905	15143	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	342	2	0	5	3.7	CN1CCN(c2nc(C3CC3)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093138	15143	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	342	2	0	5	3.7	CN1CCN(c2nc(C3CC3)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		16656872	14684	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1090190	14684	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		71548027	188629	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	395	1	0	7	1.0	CN1CCN(c2nc3ncc(I)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778591	188629	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	395	1	0	7	1.0	CN1CCN(c2nc3ncc(I)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		3934857	14875	29	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.1	Cc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091558	14875	29	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	316	1	0	5	3.1	Cc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		71547282	189852	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1C	10.1021/acs.jmedchem.7b01855
		CHEMBL4794336	189852	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	1	0	7	1.5	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1C	10.1021/acs.jmedchem.7b01855
		1278	8931	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		1279	8931	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		4908365	8931	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		CHEMBL129198	8931	84	None	-4	8	Mouse	7.4	pIC50	=	7.4	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsInhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		89477685	190353	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	1	7	1.1	CN[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4800462	190353	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	2	1	7	1.1	CN[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		89477651	190227	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	315	1	0	7	1.2	CN1C[C@@H]2C[C@H]1CN2c1nc2ncc(Cl)cc2n2cnnc12	10.1021/acs.jmedchem.7b01855
		CHEMBL4798915	190227	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	315	1	0	7	1.2	CN1C[C@@H]2C[C@H]1CN2c1nc2ncc(Cl)cc2n2cnnc12	10.1021/acs.jmedchem.7b01855
		11638468	15119	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1C2CCC1CN(c1ncnc3c1oc1ccc(Cl)cc13)C2	10.1016/j.bmcl.2010.02.097
		CHEMBL1092934	15119	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	328	1	0	5	3.3	CN1C2CCC1CN(c1ncnc3c1oc1ccc(Cl)cc13)C2	10.1016/j.bmcl.2010.02.097
		71547281	190066	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	2	0	7	1.5	CN(C)[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4796842	190066	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	317	2	0	7	1.5	CN(C)[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		1267	10576	49	None	-33	27	Human	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assayInverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-arrestin recruitment by luciferase reporter gene assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		89477709	189473	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	1	7	0.9	Clc1cnc2nc(N3C[C@@H]4C[C@H]3CN4)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4789385	189473	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	1	7	0.9	Clc1cnc2nc(N3C[C@@H]4C[C@H]3CN4)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71547597	189910	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	283	1	0	7	0.7	Cc1cnc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4795091	189910	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	283	1	0	7	0.7	Cc1cnc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71547848	189816	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	329	1	0	7	1.6	Clc1cnc2nc(N3CCN4CCCC4C3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4793974	189816	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	329	1	0	7	1.6	Clc1cnc2nc(N3CCN4CCCC4C3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71547765	189267	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	3	0	8	1.5	CCOc1nc2nc(N3CCN(C)CC3)c3nncn3c2cc1Cl	10.1021/acs.jmedchem.7b01855
		CHEMBL4786816	189267	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	3	0	8	1.5	CCOc1nc2nc(N3CCN(C)CC3)c3nncn3c2cc1Cl	10.1021/acs.jmedchem.7b01855
		71547682	188981	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	275	1	1	7	0.5	NC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4782945	188981	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	275	1	1	7	0.5	NC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		89477439	188855	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	290	2	1	8	0.1	CNC1CN(c2nc3ncc(Cl)cc3n3nnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4781484	188855	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	290	2	1	8	0.1	CNC1CN(c2nc3ncc(Cl)cc3n3nnnc23)C1	10.1021/acs.jmedchem.7b01855
		58475282	188431	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	282	1	0	6	1.3	Cc1ccc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		CHEMBL4776004	188431	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	282	1	0	6	1.3	Cc1ccc2nc(N3CCN(C)CC3)c3nncn3c2c1	10.1021/acs.jmedchem.7b01855
		71548411	189358	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	304	1	0	8	0.5	CN1CCN(c2nc3ncc(Cl)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4787983	189358	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	304	1	0	8	0.5	CN1CCN(c2nc3ncc(Cl)cc3n3nnnc23)CC1	10.1021/acs.jmedchem.7b01855
		53380276	189583	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	0	5	2.3	CN1CCN(c2cc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4790726	189583	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	301	1	0	5	2.3	CN1CCN(c2cc3ccc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		46885181	15109	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	293	2	1	6	2.0	CNC1CCN(c2ncnc3c2oc2ccc(C#N)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092880	15109	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	293	2	1	6	2.0	CNC1CCN(c2ncnc3c2oc2ccc(C#N)cc23)C1	10.1016/j.bmcl.2010.02.097
		89477539	189489	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.9	N[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4789543	189489	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	1	1	7	0.9	N[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		71515465	188923	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		CHEMBL4782303	188923	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	289	2	1	7	0.7	CNC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1	10.1021/acs.jmedchem.7b01855
		71547683	188583	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	1	0	7	1.2	CN1CCN(c2nc3ncc(Br)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4778068	188583	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	347	1	0	7	1.2	CN1CCN(c2nc3ncc(Br)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL5087167	221853	0	None	-	2	Mouse	5.2	pIC50	=	5.2	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL		None	None	None		Cn1cc2c(-c3c(-c4ccc(F)cn4)nn4c3COC(C)(C)C4)ccnc2n1	10.6019/CHEMBL5058645
		89477445	188829	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	1	7	1.1	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1	10.1021/acs.jmedchem.7b01855
		CHEMBL4781143	188829	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	1	7	1.1	C[C@H]1CN(c2nc3ncc(Cl)cc3n3cnnc23)CCN1	10.1021/acs.jmedchem.7b01855
		71547678	190119	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		CHEMBL4797517	190119	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta scintillation counting method	ChEMBL	303	1	0	7	1.1	CN1CCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1	10.1021/acs.jmedchem.7b01855
		24994634	8923	31	None	2	7	Mouse	8.1	pIC50	=	8.1	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		8984	8923	31	None	2	7	Mouse	8.1	pIC50	=	8.1	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		CHEMBL3236549	8923	31	None	2	7	Mouse	8.1	pIC50	=	8.1	Binding	mBMMC chemotaxismBMMC chemotaxis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		11682208	15046	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1092542	15046	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	370	1	0	5	3.8	CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		46885177	14901	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	282	2	1	5	2.5	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091729	14901	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	282	2	1	5	2.5	CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C)cc23)C1	10.1016/j.bmcl.2010.02.097
		1278	8931	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		1279	8931	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		4908365	8931	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		CHEMBL129198	8931	84	None	-3	8	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsInhibition of histamine H4 receptor-mediated chemotaxis in human eosinophils	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		16656874	14878	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1091569	14878	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	288	2	1	5	2.4	CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		46885298	15188	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	332	2	0	6	2.8	COc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093439	15188	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	332	2	0	6	2.8	COc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2010.02.097
		16656870	14493	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CNC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		CHEMBL1088889	14493	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayDisplacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay	ChEMBL	302	2	1	5	2.8	CNC1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2010.02.097
		1278	8931	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		1279	8931	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		4908365	8931	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		CHEMBL129198	8931	84	None	-3	8	Human	8.0	pKd	=	8	Binding	pA2 value against histamine h4 receptorpA2 value against histamine h4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		71525681	96503	0	None	2	6	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	96503	0	None	2	6	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		11846300	87041	3	None	-2	4	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	87041	3	None	-2	4	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		156013896	185019	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		135398737	7745	93	None	-57	90	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	7745	93	None	-57	90	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	7745	93	None	-57	90	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	7745	93	None	-57	90	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	7745	93	None	-57	90	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		24994634	8923	31	None	-2	7	Human	7.9	pKd	=	7.9	Binding	Cell based cAMP Assays (pA2)Cell based cAMP Assays (pA2)	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		8984	8923	31	None	-2	7	Human	7.9	pKd	=	7.9	Binding	Cell based cAMP Assays (pA2)Cell based cAMP Assays (pA2)	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKd	=	7.9	Binding	Cell based cAMP Assays (pA2)Cell based cAMP Assays (pA2)	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		11846300	87041	3	None	-2	4	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	87041	3	None	-2	4	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 10 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		71519674	96504	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	96504	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		1204	8713	119	None	-12	25	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	8713	119	None	-12	25	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	8713	119	None	-12	25	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	8713	119	None	-12	25	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	8713	119	None	-12	25	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	8713	119	None	-12	25	Rat	6.9	pKd	=	6.9	Binding	Binding affinity to rat H4RBinding affinity to rat H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		135398737	7745	93	None	-57	90	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	7745	93	None	-57	90	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	7745	93	None	-57	90	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	7745	93	None	-57	90	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	7745	93	None	-57	90	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		155513612	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156015638	185051	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	185051	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	185051	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1247	8713	119	None	-3	25	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1375	8713	119	None	-3	25	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		774	8713	119	None	-3	25	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		CHEMBL90	8713	119	None	-3	25	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		DB05381	8713	119	None	-3	25	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		119570	9933	96	None	-181	39	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		2233	9933	96	None	-181	39	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		953	9933	96	None	-181	39	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		CHEMBL301265	9933	96	None	-181	39	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		DB00413	9933	96	None	-181	39	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		168268716	199541	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5170276	199541	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221176	199541	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168268680	199545	0	None	-2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5172675	199545	0	None	-2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221210	199545	0	None	-2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		168268827	199558	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5179906	199558	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221314	199558	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		168268853	199564	0	None	-83	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5180504	199564	0	None	-83	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221353	199564	0	None	-83	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		168273471	199580	0	None	-50	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173079	199580	0	None	-50	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221433	199580	0	None	-50	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273549	199582	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174342	199582	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221438	199582	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		168273640	199584	0	None	-12	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176229	199584	0	None	-12	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221444	199584	0	None	-12	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273745	199587	0	None	-11	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5178472	199587	0	None	-11	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221451	199587	0	None	-11	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		168274129	199588	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176780	199588	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221468	199588	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168275750	199605	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5175558	199605	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221581	199605	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		168276867	199614	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174278	199614	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221653	199614	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		168277996	199625	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173373	199625	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221736	199625	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		168278471	199627	0	None	-17	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183205	199627	0	None	-17	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221757	199627	0	None	-17	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		168278543	199630	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184846	199630	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221764	199630	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168280339	199644	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5188592	199644	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221885	199644	0	None	-3	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168281536	199660	0	None	2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5189006	199660	0	None	2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221966	199660	0	None	2	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		168281746	199661	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184911	199661	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221974	199661	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		168283097	199672	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5186770	199672	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222043	199672	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		168283321	199674	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183015	199674	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222057	199674	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		168283536	199679	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5187758	199679	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222074	199679	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		168284289	199685	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5194860	199685	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222123	199685	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168284480	199689	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5197548	199689	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222137	199689	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		168286141	199703	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5192993	199703	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222231	199703	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		168286426	199705	0	None	-109	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5198795	199705	0	None	-109	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222241	199705	0	None	-109	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168290235	199747	0	None	-1071	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	199747	0	None	-1071	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	199747	0	None	-1071	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168290815	199752	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200771	199752	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222529	199752	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168291233	199758	0	None	5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200106	199758	0	None	5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222556	199758	0	None	5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		168292954	199776	0	None	-112	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5202592	199776	0	None	-112	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222660	199776	0	None	-112	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		168294161	199785	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204739	199785	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222742	199785	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		168294445	199789	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208113	199789	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222768	199789	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		168294166	199793	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209081	199793	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222775	199793	0	None	-4	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		168294449	199797	0	None	-181	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204599	199797	0	None	-181	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222793	199797	0	None	-181	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		168294767	199798	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294770	199799	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208327	199799	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222806	199799	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		168294776	199805	0	None	7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209479	199805	0	None	7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222831	199805	0	None	7	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		168295528	199810	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	199810	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	199810	0	None	-301	20	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294178	199814	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5205197	199814	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222887	199814	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168295541	199819	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208845	199819	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222926	199819	0	None	-1071	6	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168295543	199820	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209021	199820	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222929	199820	0	None	-8	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		168295803	199824	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207206	199824	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222937	199824	0	None	-6	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168294182	199827	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208722	199827	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222960	199827	0	None	-5	4	Human	7.8	pKd	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		156013896	185019	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156015638	185051	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	185051	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	185051	0	None	-158	4	Mouse	6.8	pKd	=	6.8	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		155513612	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.8	pKd	=	7.8	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	185019	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		135398737	7745	93	None	-57	90	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	7745	93	None	-57	90	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	7745	93	None	-57	90	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	7745	93	None	-57	90	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	7745	93	None	-57	90	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		71525679	96501	0	None	6	6	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	96501	0	None	6	6	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		155513612	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-2	4	Rat	7.7	pKd	=	7.7	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		11846300	87041	3	None	-2	4	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	87041	3	None	-2	4	Human	7.7	pKd	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 30 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		24745335	7083	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	7083	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	7083	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	7083	12	None	4	5	Human	7.6	pKd	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		1278	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		1279	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		4908365	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2013.02.091
		1223	7740	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		2790	7740	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		CHEMBL14690	7740	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		1223	7740	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		2790	7740	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		CHEMBL14690	7740	41	None	-60	11	Human	7.5	pKd	=	7.5	Binding	Binding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H4R expressed in HEK293T cell homogenates using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.2c00125
		156013896	185019	0	None	-22	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		155513612	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.5	pKd	=	7.5	Binding	Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-2	4	Rat	7.5	pKd	=	7.5	Binding	Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	185019	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		56835171	76515	0	None	1	9	Human	7.4	pKd	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL1935574	76515	0	None	1	9	Human	7.4	pKd	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		155513612	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	185019	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	7.4	pKd	=	7.4	Binding	Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-15	25	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	8713	119	None	-15	25	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	8713	119	None	-15	25	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	8713	119	None	-15	25	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	8713	119	None	-15	25	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	8713	119	None	-15	25	Mouse	7.4	pKd	=	7.4	Binding	Binding affinity to mouse H4RBinding affinity to mouse H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		156013896	185019	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1247	8713	119	None	-3	25	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1375	8713	119	None	-3	25	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		774	8713	119	None	-3	25	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL90	8713	119	None	-3	25	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		DB05381	8713	119	None	-3	25	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		156013896	185019	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.3	pKd	=	7.3	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		155513612	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		155513612	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyBinding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding study	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156013896	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156013896	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryBinding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometry	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156013896	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-22	4	Mouse	7.2	pKd	=	7.2	Binding	Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		135398737	7745	93	None	-57	90	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	7745	93	None	-57	90	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	7745	93	None	-57	90	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	7745	93	None	-57	90	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	7745	93	None	-57	90	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uMDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		11846300	87041	3	None	-2	4	Human	7.1	pKd	=	7.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	87041	3	None	-2	4	Human	7.1	pKd	=	7.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nMDisplacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		156015638	185051	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	185051	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	185051	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		156015638	185051	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	185051	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	185051	0	None	-58	4	Human	7.1	pKd	=	7.1	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		71525678	96500	0	None	5	6	Human	8.1	pKd	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	96500	0	None	5	6	Human	8.1	pKd	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysisDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells by competitive kinetic analysis	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		156013896	185019	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assayBinding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in presence of thioperamide by furimazine substrate based BRET assay	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		54587788	68309	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	4	3	5	1.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770975	68309	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	4	3	5	1.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		23653543	74823	2	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914541	74823	2	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		54587787	68305	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770971	68305	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	5	3	5	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		46235428	13376	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083162	13376	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	407	9	3	4	4.3	Cc1cc(OCCCNCCc2c[nH]cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		54586763	68302	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	3	2	5	1.9	CN1CCN(c2cc(N)nc(NCC(C)(C)C)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770968	68302	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	3	2	5	1.9	CN1CCN(c2cc(N)nc(NCC(C)(C)C)c2)CC1	10.1016/j.bmcl.2011.03.017
		24826169	74815	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914462	74815	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		16718567	14934	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1091874	14934	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24737950	74906	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	361	2	2	6	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914781	74906	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	361	2	2	6	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		58227148	123911	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393547	123911	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		57399746	74881	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914755	74881	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		54580885	68307	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	4	3	5	1.8	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770973	68307	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	4	3	5	1.8	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		24826766	74876	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914750	74876	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CNC1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		59777338	116905	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236556	116905	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		1204	8713	119	None	-3	25	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		1247	8713	119	None	-3	25	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		1375	8713	119	None	-3	25	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		774	8713	119	None	-3	25	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		CHEMBL90	8713	119	None	-3	25	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		DB05381	8713	119	None	-3	25	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmc.2020.115924
		1223	7740	41	None	-60	11	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		54581940	68326	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770992	68326	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(N)nc(NCC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		24797598	68336	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1771001	68336	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(NC3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		11224088	143235	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1021/jm800876b
		CHEMBL373579	143235	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1021/jm800876b
		24798144	116902	2	None	19	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3236553	116902	2	None	19	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		58227342	123898	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393534	123898	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		11224088	143235	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		CHEMBL373579	143235	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		24825998	74886	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914760	74886	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)CC1	10.1016/j.bmcl.2011.08.014
		57396301	74908	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	2.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914783	74908	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	2.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(C(F)(F)F)cc23)C1	10.1016/j.bmcl.2011.08.014
		127050310	147613	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	347	3	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(C(C)(F)F)cc23)C1	10.1039/C6MD00108D
		CHEMBL3819260	147613	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	347	3	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(C(C)(F)F)cc23)C1	10.1039/C6MD00108D
		46222048	15756	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1016/j.bmc.2010.04.052
		CHEMBL1098230	15756	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1016/j.bmc.2010.04.052
		24994542	116903	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236554	116903	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		24948752	74822	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.4	Nc1nc(N2CCCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914540	74822	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.4	Nc1nc(N2CCCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		24825727	74824	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914542	74824	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		46222048	15756	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Inhibition of human recombinant histamine H4 receptor expressed in CHO cellsInhibition of human recombinant histamine H4 receptor expressed in CHO cells	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1021/jm901890s
		CHEMBL1098230	15756	0	None	-4	13	Human	9.0	pKi	=	9.0	Binding	Inhibition of human recombinant histamine H4 receptor expressed in CHO cellsInhibition of human recombinant histamine H4 receptor expressed in CHO cells	ChEMBL	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	10.1021/jm901890s
		155524115	183326	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	183326	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	183326	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		24798144	116902	2	None	19	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		CHEMBL3236553	116902	2	None	19	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		155524115	183326	0	None	1	3	Mouse	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	183326	0	None	1	3	Mouse	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	183326	0	None	1	3	Mouse	8.9	pKi	=	8.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		24797604	116901	2	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
		CHEMBL3236552	116901	2	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	1	5	1.5	CN1CCN(c2cc(C3CCCC3)nc(N)n2)CC1	10.1021/jm401727m
		44231618	12662	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1079516	12662	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		25128824	199957	0	None	3	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		CHEMBL523225	199957	0	None	3	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		24992077	116920	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236571	116920	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	5	2	5	1.2	CCCCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		44231618	12662	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1079516	12662	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	287	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		44129130	206335	0	None	2	2	Rat	8.8	pKi	=	8.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592379	206335	0	None	2	2	Rat	8.8	pKi	=	8.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		1223	7740	41	None	-60	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		44187557	202278	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202332	202278	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL553423	202278	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	342	6	3	3	4.1	N=C(NCc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1204	8713	119	None	-3	25	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		1247	8713	119	None	-3	25	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		1375	8713	119	None	-3	25	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		774	8713	119	None	-3	25	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		CHEMBL90	8713	119	None	-3	25	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		DB05381	8713	119	None	-3	25	Human	8.8	pKi	=	8.8	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2016.09.049
		11957573	8791	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		1250	8791	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		3692	8791	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		CHEMBL19439	8791	34	None	-40	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2011.03.046
		16202258	74993	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915536	74993	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	264	4	3	6	0.9	CNC1CN(c2cc(NCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		66740859	116928	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	327	3	2	5	2.3	CN[C@@H]1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236579	116928	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	327	3	2	5	2.3	CN[C@@H]1CCN(c2cc(C34CC5CC(CC(C5)C3)C4)nc(N)n2)C1	10.1021/jm401727m
		24798232	116909	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	1.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCCN[C@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236560	116909	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	1.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCCN[C@H]3C2)n1	10.1021/jm401727m
		44231735	14557	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089390	14557	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		25129527	194193	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL493720	194193	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		135525668	74987	0	None	263	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915348	74987	0	None	263	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		25217643	118947	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysis	ChEMBL	289	2	0	5	1.9	CN1CCN(c2ncnc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290570	118947	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysis	ChEMBL	289	2	0	5	1.9	CN1CCN(c2ncnc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		1249	8790	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		13499360	8790	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90019	8790	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10176414	10835	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1246	10835	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL281576	10835	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10060212	211313	0	None	5	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL72769	211313	0	None	5	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CCC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		71681807	96421	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	8	3	8	1.6	CC(C)CCc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375668	96421	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	8	3	8	1.6	CC(C)CCc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		71681804	96446	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1ccnc(N)n1)c1cc(-c2ccccc2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375770	96446	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1ccnc(N)n1)c1cc(-c2ccccc2)nc(N)n1	10.1021/jm301886t
		1223	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		1223	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		1249	8790	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm0504353
		13499360	8790	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm0504353
		CHEMBL90019	8790	16	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm0504353
		53233802	68321	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770987	68321	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	3	2	6	1.2	CN1CCN(c2cc(N)nc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		70692529	82458	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	303	2	1	2	2.7	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047466	82458	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	303	2	1	2	2.7	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		46228994	206208	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	466	6	1	7	2.7	CC1CCCCN1S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591249	206208	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	466	6	1	7	2.7	CC1CCCCN1S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		1223	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2009.04.007
		2790	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2009.04.007
		CHEMBL14690	7740	41	None	-60	11	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2009.04.007
		45268092	202793	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	352	6	3	3	3.6	N=C(NCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1743881	202793	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	352	6	3	3	3.6	N=C(NCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560111	202793	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	352	6	3	3	3.6	N=C(NCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		45268093	202794	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	400	6	3	3	3.4	N=C(NCc1ccc(I)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202321	202794	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	400	6	3	3	3.4	N=C(NCc1ccc(I)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560112	202794	0	None	-3	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	400	6	3	3	3.4	N=C(NCc1ccc(I)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		45267230	203261	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202318	203261	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL563342	203261	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1ccccc1Cl)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		24737954	74904	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(F)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914778	74904	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(F)c23)C1	10.1016/j.bmcl.2011.08.014
		24826522	74911	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914786	74911	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		24826168	74914	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914789	74914	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24745335	7083	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	7083	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	7083	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	7083	12	None	4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		71525680	96506	0	None	97	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	284	3	2	6	1.3	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376806	96506	0	None	97	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	284	3	2	6	1.3	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		71525678	96500	0	None	5	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	96500	0	None	5	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25101945	199885	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL522673	199885	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		136192886	63254	0	None	-1	4	Mouse	7.0	pKi	=	7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632411	63254	0	None	-1	4	Mouse	7.0	pKi	=	7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		44129134	206287	0	None	-22	2	Rat	7.0	pKi	=	7	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591969	206287	0	None	-22	2	Rat	7.0	pKi	=	7	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		11694543	82574	4	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	6	2	2	1.3	CCNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL204843	82574	4	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	6	2	2	1.3	CCNCCCCc1c[nH]cn1	10.1021/jm0504353
		11521414	148075	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	2	2	2.7	c1nc(CCCCNC2CCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL383324	148075	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	2	2	2.7	c1nc(CCCCNC2CCCCC2)c[nH]1	10.1021/jm0504353
		9812843	212023	1	None	-4	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1016/j.bmcl.2011.06.123
		CHEMBL78838	212023	1	None	-4	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1016/j.bmcl.2011.06.123
		53233904	68299	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770965	68299	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	2	1	5	1.0	CN1CCN(c2cc(N)nc(N3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		39732699	82455	2	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	1	2	2	1.4	O=C(c1cc2cccc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047463	82455	2	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	1	2	2	1.4	O=C(c1cc2cccc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		70696623	82463	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	2	2	2	2.0	CNC1CN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047471	82463	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	2	2	2	2.0	CNC1CN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		51354298	65661	2	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	233	4	1	4	1.9	CC(C)(C)c1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		CHEMBL1688944	65661	2	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	233	4	1	4	1.9	CC(C)(C)c1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		45267237	202981	0	None	-7	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	7	3	3	3.2	Cc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202320	202981	0	None	-7	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	7	3	3	3.2	Cc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL561451	202981	0	None	-7	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	7	3	3	3.2	Cc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		53378933	116922	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	269	3	2	5	1.2	Nc1nc(Cc2ccccc2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236573	116922	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	269	3	2	5	1.2	Nc1nc(Cc2ccccc2)cc(N2CC[C@@H](N)C2)n1	10.1021/jm401727m
		11087453	82419	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL2047270	82419	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1039/C2MD20212C
		44395335	73836	0	None	25	2	Human	6.0	pKi	=	6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	266	4	2	3	1.5	CN(C)CCNC(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL187210	73836	0	None	25	2	Human	6.0	pKi	=	6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	266	4	2	3	1.5	CN(C)CCNC(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		10978141	11922	1	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL105803	11922	1	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		71681477	96433	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	398	7	4	8	3.3	Nc1nc(NCCNc2cc(-c3ccccc3)nc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		CHEMBL2375758	96433	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	398	7	4	8	3.3	Nc1nc(NCCNc2cc(-c3ccccc3)nc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		71681802	96444	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1cc(NCCNc2ccnc(N)n2)ncn1	10.1021/jm301886t
		CHEMBL2375769	96444	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1cc(NCCNc2ccnc(N)n2)ncn1	10.1021/jm301886t
		206876	25717	7	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL128637	25717	7	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		66572107	82414	1	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047265	82414	1	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		66572115	82434	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047442	82434	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		11469514	110945	2	None	-64	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL309654	110945	2	None	-64	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cc(CCCc2c[nH]cn2)ccn1	10.1021/jm049932u
		46890591	13797	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	436	6	1	4	4.8	Cc1cc(OCCCN2CC3CCCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084811	13797	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	436	6	1	4	4.8	Cc1cc(OCCCN2CC3CCCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		44275807	105746	0	None	-9120	10	Human	5.0	pKi	=	5	Binding	Binding affinity towards human histaminergic (H4) receptorBinding affinity towards human histaminergic (H4) receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		CHEMBL27979	105746	0	None	-9120	10	Human	5.0	pKi	=	5	Binding	Binding affinity towards human histaminergic (H4) receptorBinding affinity towards human histaminergic (H4) receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		4242418	124210	12	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	2	1	2	1.9	CN1CCN(Cc2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL339826	124210	12	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	2	1	2	1.9	CN1CCN(Cc2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		71681978	96428	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	310	5	3	5	1.7	CN(CCNc1ccnc(N)n1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm301886t
		CHEMBL2375753	96428	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	310	5	3	5	1.7	CN(CCNc1ccnc(N)n1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm301886t
		58227158	123913	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1cc(N2CCN(C)CC2)cnn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393549	123913	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1cc(N2CCN(C)CC2)cnn1	10.1016/j.bmcl.2014.12.027
		57391926	76677	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938967	76677	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		11846300	87041	3	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL213912	87041	3	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2015.12.035
		24854583	102897	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	304	2	0	4	3.0	CN1CCN(c2nc3ccccc3nc2-c2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260372	102897	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	304	2	0	4	3.0	CN1CCN(c2nc3ccccc3nc2-c2ccccc2)CC1	10.1021/jm7014217
		16082860	145389	0	None	-7	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL377572	145389	0	None	-7	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		57391032	74875	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@H]3C[C@@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914749	74875	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@H]3C[C@@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25179297	180610	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL453877	180610	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		24759518	186088	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL473302	186088	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178342	193565	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489070	193565	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25179297	180610	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL453877	180610	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3nccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25178342	193565	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489070	193565	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	385	4	1	5	3.8	CN1CCN(c2nc(NCc3ccc(F)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		71518535	93262	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	1	5	2.6	CN1CCN(c2nc(N(C)C)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314763	93262	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	1	5	2.6	CN1CCN(c2nc(N(C)C)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		10978141	11922	1	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL105803	11922	1	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		57393730	74659	0	None	-2754	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910386	74659	0	None	-2754	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
		24826681	74894	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914768	74894	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.0	Nc1nc(N2CCNCC2)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		127049855	147006	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	147006	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		57391869	69894	0	None	-19	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774589	69894	0	None	-19	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789349	69894	0	None	-19	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		90645163	118967	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1cc(C)cc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290590	118967	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1cc(C)cc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		10656971	23193	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL123137	23193	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1016/j.bmcl.2011.07.114
		121238070	173266	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4278404	173266	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		25178555	181018	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454891	181018	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178555	181018	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL454891	181018	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	374	4	1	7	3.1	CN1CCN(c2nc(NCc3cncs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		155540201	179687	0	None	-67	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	513	16	2	4	5.5	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1	10.1039/C8MD00527C
		CHEMBL4516173	179687	0	None	-67	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	513	16	2	4	5.5	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1	10.1039/C8MD00527C
		1278	8931	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	8931	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	8931	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	8931	84	None	-281	8	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		832283	19170	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL118572	19170	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		832283	19170	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL118572	19170	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc(NCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		10269628	145494	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	355	1	0	4	4.6	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL377985	145494	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	355	1	0	4	4.6	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		54582866	68322	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(N)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770988	68322	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(N)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2011.03.017
		25133970	194367	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL494679	194367	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	1	1	6	0.5	CN1CCN(c2nc(N)nc(C(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		49841962	76503	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3c(-c4ccoc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935562	76503	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3c(-c4ccoc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		44547568	123894	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393530	123894	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		13731320	165429	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	2	2	2	4.0	O=C(Nc1cccc2ccccc12)N1CCC(c2c[nH]cn2)CC1	10.1016/j.ejmech.2016.09.074
		CHEMBL4092578	165429	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	2	2	2	4.0	O=C(Nc1cccc2ccccc12)N1CCC(c2c[nH]cn2)CC1	10.1016/j.ejmech.2016.09.074
		127035837	144195	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	403	4	1	5	3.7	CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753334	144195	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	403	4	1	5	3.7	CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		21842421	118948	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	270	2	1	6	0.9	CN1CCN(c2nc(N)nc(-c3ccccc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290571	118948	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	270	2	1	6	0.9	CN1CCN(c2nc(N)nc(-c3ccccc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		10688021	162890	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	332	8	1	3	4.3	O=C(/C=C/c1ccccc1)c1ccc(OCCCc2c[nH]cn2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4063170	162890	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	332	8	1	3	4.3	O=C(/C=C/c1ccccc1)c1ccc(OCCCc2c[nH]cn2)cc1	10.1016/j.ejmech.2016.09.074
		9944571	123795	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL338937	123795	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9944571	123795	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL338937	123795	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		23650961	10618	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		9276	10618	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		CHEMBL3301609	10618	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		DB12522	10618	26	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	nan
		24803710	157108	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	400	6	2	5	4.1	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(F)c(F)ccc2[nH]1	nan
		CHEMBL3953011	157108	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	400	6	2	5	4.1	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(F)c(F)ccc2[nH]1	nan
		25101945	199885	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL522673	199885	0	None	-3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		118720437	122691	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	275	3	2	5	1.0	CN[C@@H]1CCN(c2cc(CC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354811	122691	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	275	3	2	5	1.0	CN[C@@H]1CCN(c2cc(CC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		24737952	74909	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(OC)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914784	74909	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(OC)cc23)C1	10.1016/j.bmcl.2011.08.014
		9944571	123795	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338937	123795	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3cc(Cl)cc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		24996854	116913	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
		CHEMBL3236564	116913	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	2	5	2.0	Nc1nc(C2CCCC2)cc(N2CCC3(CCCN3)C2)n1	10.1021/jm401727m
		71603142	96496	0	None	54	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	3	2	5	1.2	CCc1ccc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376796	96496	0	None	54	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	3	2	5	1.2	CCc1ccc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		44129282	205978	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)cc(Cl)c3n2)CC1	10.1021/jm901379s
		CHEMBL589746	205978	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)cc(Cl)c3n2)CC1	10.1021/jm901379s
		71603139	96493	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	2	2	5	1.5	Nc1nc(N2CCNCC2)c2ccc(C3CC3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376793	96493	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	2	2	5	1.5	Nc1nc(N2CCNCC2)c2ccc(C3CC3)cc2n1	10.1016/j.bmcl.2013.02.091
		45257132	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		8983	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		CHEMBL595180	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		155513612	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		44450493	103309	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	1	1	4	1.3	CN1CCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		CHEMBL262859	103309	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	1	1	4	1.3	CN1CCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		1278	8931	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-4	8	Mouse	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		126963283	167742	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL4115677	167742	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		1224	8214	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	8214	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	8214	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	8214	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	8214	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	8214	83	None	-194	13	Human	5.0	pKi	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		1241	8818	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		1242	8818	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		3614	8818	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		CHEMBL507	8818	52	None	-89	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	125	2	1	3	-0.1	Cn1cc(nc1)CCN	10.1016/j.bmcl.2016.09.049
		49841609	76497	15	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3c(Br)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935556	76497	15	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3c(Br)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		51354871	65679	0	None	-22	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	290	6	0	4	3.3	c1c(CC2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		CHEMBL1688982	65679	0	None	-22	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	290	6	0	4	3.3	c1c(CC2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		164618508	192711	0	None	-363	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	6	4	4	2.7	Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4869194	192711	0	None	-363	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	6	4	4	2.7	Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		164620678	192798	0	None	-177	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.7	CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4870510	192798	0	None	-177	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.7	CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		58227159	183164	0	None	47	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	1	5	1.7	CN1CCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4534254	183164	0	None	47	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	1	5	1.7	CN1CCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595907	183164	0	None	47	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	1	5	1.7	CN1CCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		122193099	130696	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	374	3	1	6	2.1	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Br)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628046	130696	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	374	3	1	6	2.1	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Br)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		51354008	65656	0	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	253	5	1	4	1.8	c1ccc(Cc2cn(CCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688939	65656	0	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	253	5	1	4	1.8	c1ccc(Cc2cn(CCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		51354586	65676	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	2.9	CC(c1cn(CCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		CHEMBL1688978	65676	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	2.9	CC(c1cn(CCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		16082824	84723	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL209598	84723	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		54585778	68323	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(N)nc(NCCO)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770989	68323	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(N)nc(NCCO)n2)CC1	10.1016/j.bmcl.2011.03.017
		58227165	123900	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393536	123900	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	1	5	1.0	CC(C)Nc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		24853664	103116	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261517	103116	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		10773349	14863	1	None	-11	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL109130	14863	1	None	-11	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		10715857	81791	1	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	398	8	1	3	3.5	O=C(CCCc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		CHEMBL20338	81791	1	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	398	8	1	3	3.5	O=C(CCCc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		16082820	86893	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL213250	86893	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	261	5	2	2	3.0	Clc1ccc(CNC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		10776393	12268	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	239	7	2	3	2.1	CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1076267	12268	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	239	7	2	3	2.1	CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL156912	12268	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	239	7	2	3	2.1	CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		118725542	123901	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393537	123901	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		1278	8931	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1279	8931	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		4908365	8931	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL129198	8931	84	None	-3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		90645161	118965	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3cc(F)cc(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290588	118965	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3cc(F)cc(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		45257132	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		8983	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		CHEMBL595180	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	10.1016/j.bmc.2009.08.059
		24994634	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1016/j.bmcl.2014.12.027
		24994634	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1016/j.bmcl.2014.12.027
		8984	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1016/j.bmcl.2014.12.027
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		24994635	116919	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236570	116919	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(C(C)C)nc(N)n2)C1	10.1021/jm401727m
		24826442	74882	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1ccc2oc3c(N4CCN(C)CC4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914756	74882	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1ccc2oc3c(N4CCN(C)CC4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm1013488
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014217
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm901379s
		155513612	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		1226	8800	20	None	2	7	Human	7.9	pKi	=	7.9	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm0341047
		41376	8800	20	None	2	7	Human	7.9	pKi	=	7.9	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm0341047
		CHEMBL12608	8800	20	None	2	7	Human	7.9	pKi	=	7.9	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm0341047
		24745335	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		71603135	96489	0	None	26	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	2	2	5	2.3	Nc1nc(N2CCNCC2)c2ccc(C3CCCC3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376789	96489	0	None	26	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	2	2	5	2.3	Nc1nc(N2CCNCC2)c2ccc(C3CCCC3)cc2n1	10.1016/j.bmcl.2013.02.091
		71525589	96507	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	286	3	2	6	1.5	CN[C@@H]1CCN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376807	96507	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	286	3	2	6	1.5	CN[C@@H]1CCN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		24745335	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	7083	12	None	-4	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		24994634	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Binding assayBinding assay	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		8984	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Binding assayBinding assay	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Binding assayBinding assay	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.6019/CHEMBL5058644
		24994634	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		3035746	194959	9	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL1237146	194959	9	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		CHEMBL498770	194959	9	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human H4RBinding affinity to human H4R	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.9b01342
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		155513612	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	183099	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1249	8790	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		13499360	8790	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90019	8790	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1253	8839	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		132937	8839	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL19010	8839	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10023327	175795	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor Q7.42L mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		10023327	175795	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		10023327	175795	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T6.55M mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		1253	8839	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1021/jm201042n
		132937	8839	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1021/jm201042n
		CHEMBL19010	8839	7	None	-11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	10.1021/jm201042n
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm060880d
		11065080	26206	2	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL129488	26206	2	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		66573460	82443	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.2	Cc1cc(Cl)cc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047451	82443	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.2	Cc1cc(Cl)cc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		21638785	195437	5	None	-4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL503605	195437	5	None	-4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		44129132	206313	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	6	1	7	1.3	CN1CCN(c2nc(NCCS(=O)(=O)N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592188	206313	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	6	1	7	1.3	CN1CCN(c2nc(NCCS(=O)(=O)N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10176414	10835	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		1246	10835	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL281576	10835	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	184	4	3	3	1.0	NC(=N)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		45267233	201686	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	304	7	3	4	2.8	COc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202319	201686	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	304	7	3	4	2.8	COc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL541171	201686	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	304	7	3	4	2.8	COc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1249	8790	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		13499360	8790	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90019	8790	16	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		25128823	199496	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		CHEMBL521995	199496	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		127050431	147093	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806206	147093	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11451949	74820	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	384	6	1	4	3.9	CN1CCN(CCCOc2ccc(-c3nc4cc(Cl)ccc4[nH]3)cc2)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914533	74820	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	384	6	1	4	3.9	CN1CCN(CCCOc2ccc(-c3nc4cc(Cl)ccc4[nH]3)cc2)CC1	10.1016/j.bmcl.2011.08.014
		46228126	209391	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.4	CN1CCN(c2cc(NCc3ccc(C(F)(F)F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL612131	209391	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.4	CN1CCN(c2cc(NCc3ccc(C(F)(F)F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		60150166	181503	0	None	-323	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	524	17	2	6	4.7	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1	10.1039/C8MD00527C
		CHEMBL4560123	181503	0	None	-323	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	524	17	2	6	4.7	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1	10.1039/C8MD00527C
		168295543	199820	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209021	199820	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222929	199820	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		164610648	191617	0	None	-120	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4852212	191617	0	None	-120	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		10820930	12571	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL107877	12571	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@H]1C=C[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		24826443	74896	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914770	74896	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		10800875	13052	0	None	-75	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1081718	13052	0	None	-75	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL345828	13052	0	None	-75	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		24745335	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		24745335	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	7083	12	None	-22	5	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		1223	7740	41	None	-363	11	Mouse	6.9	pKi	=	6.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-363	11	Mouse	6.9	pKi	=	6.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-363	11	Mouse	6.9	pKi	=	6.9	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		10800875	13052	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1081718	13052	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL345828	13052	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	253	8	2	3	2.5	CCC(C)CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		11206058	111192	9	None	-10	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL310360	111192	9	None	-10	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1ccc(CCc2c[nH]cn2)nc1	10.1021/jm049932u
		1267	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
		3035905	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
		CHEMBL260374	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0603318
		3062060	17153	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	221	4	6	3	-1.0	N=C(N)NCc1cccc(CNC(=N)N)n1	10.1021/jm7014777
		CHEMBL1162346	17153	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	221	4	6	3	-1.0	N=C(N)NCc1cccc(CNC(=N)N)n1	10.1021/jm7014777
		11511026	22808	0	None	-208	4	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3ccc4ccccc4n3)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		CHEMBL1223683	22808	0	None	-208	4	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3ccc4ccccc4n3)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		1267	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		3035905	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		CHEMBL260374	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		10106063	116048	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting method	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
		CHEMBL321860	116048	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation counting method	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/acs.jmedchem.6b00120
		24826000	74918	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	2	2	6	3.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914793	74918	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	2	2	6	3.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)C1	10.1016/j.bmcl.2011.08.014
		1267	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		3035905	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		CHEMBL260374	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		1278	8931	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-4	8	Mouse	6.9	pKi	=	6.9	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		10106063	116048	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL321860	116048	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		9974306	211253	0	None	-15	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL72372	211253	0	None	-15	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1016/j.bmcl.2010.10.041
		56849569	78387	0	None	-77	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	381	7	2	4	4.4	N#Cc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923033	78387	0	None	-77	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	381	7	2	4	4.4	N#Cc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963332	78387	0	None	-77	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	381	7	2	4	4.4	N#Cc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11499453	82986	0	None	-79	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	2	2	2.4	CC(C)CNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205834	82986	0	None	-79	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	2	2	2.4	CC(C)CNCCCCCc1c[nH]cn1	10.1021/jm0504353
		11672850	83448	3	None	-10	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.1	CC(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL206451	83448	3	None	-10	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.1	CC(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		1267	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.04.007
		3035905	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.04.007
		CHEMBL260374	10576	49	None	-33	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.04.007
		10106063	116048	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL321860	116048	10	None	16	2	Human	6.9	pKi	=	6.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		5310982	100387	4	None	-1348	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
		CHEMBL24665	100387	4	None	-1348	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
		71681975	96425	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	296	5	4	5	1.4	Nc1nccc(NCCNC(=O)c2cc3ccccc3[nH]2)n1	10.1021/jm301886t
		CHEMBL2375750	96425	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	296	5	4	5	1.4	Nc1nccc(NCCNC(=O)c2cc3ccccc3[nH]2)n1	10.1021/jm301886t
		71681642	96440	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nc(NCCNc2ccnc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		CHEMBL2375765	96440	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nc(NCCNc2ccnc(N)n2)cc(-c2ccccc2)n1	10.1021/jm301886t
		11286909	212063	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL79126	212063	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1ccc(CCCc2c[nH]cn2)nc1	10.1021/jm049932u
		10678661	12134	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106931	12134	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		11043445	63253	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632410	63253	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		168294449	199797	0	None	-181	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204599	199797	0	None	-181	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222793	199797	0	None	-181	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		66572111	82420	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047271	82420	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		118720435	122690	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	225	3	2	5	0.3	CN[C@@H]1CCN(c2cc(CF)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354809	122690	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	225	3	2	5	0.3	CN[C@@H]1CCN(c2cc(CF)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		90645151	118949	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290572	118949	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2014.06.032
		16082833	87122	0	None	-23	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL214312	87122	0	None	-23	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		54584826	68327	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770993	68327	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		57395538	74986	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915347	74986	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		57395538	74986	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915347	74986	0	None	151	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		25178343	179370	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL448962	179370	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178343	179370	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL448962	179370	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	392	4	1	6	3.5	CN1CCN(c2nc(NCc3ccc(C#N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		57403269	74892	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	1	6	2.5	CN1CCN(c2nc(N)nc3c4cc(Cl)ccc4[s+]([O-])c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914766	74892	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	1	6	2.5	CN1CCN(c2nc(N)nc3c4cc(Cl)ccc4[s+]([O-])c23)CC1	10.1016/j.bmcl.2011.08.014
		24854705	102886	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	3	0	6	2.6	CN1CCN(c2nc3ccccc3nc2Oc2cccnc2)CC1	10.1021/jm7014217
		CHEMBL260274	102886	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	3	0	6	2.6	CN1CCN(c2nc3ccccc3nc2Oc2cccnc2)CC1	10.1021/jm7014217
		164619208	192441	0	None	-446	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F	10.1016/j.ejmech.2021.113190
		CHEMBL4864852	192441	0	None	-446	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F	10.1016/j.ejmech.2021.113190
		10678661	12134	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106931	12134	1	None	-61	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		57402929	76642	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938844	76642	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		57392827	74898	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914772	74898	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.4	Nc1nc(N2CCNCC2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		58227163	183242	0	None	40	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4518374	183242	0	None	40	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596491	183242	0	None	40	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	3	2	5	1.7	CC(C)(C)CNc1nccc(N2CCCNCC2)n1	10.1021/acs.jmedchem.9b01342
		1204	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		1247	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		1375	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		774	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		DB05381	8713	119	None	-3	25	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm7014777
		16082856	87888	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL215628	87888	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		46929647	23530	0	None	-91	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		CHEMBL1243394	23530	0	None	-91	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		11858011	165782	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	9	0	3	4.6	O=C(c1ccccc1)c1ccc(OCCCCCN2CCCC2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4096444	165782	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	9	0	3	4.6	O=C(c1ccccc1)c1ccc(OCCCCCN2CCCC2)cc1	10.1016/j.ejmech.2016.09.074
		16352	123963	13	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL339414	123963	13	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	293	0	0	4	3.1	CN1CCN(C2=Nc3ccccc3Oc3ccccc32)CC1	10.1021/jm051008s
		11240759	111990	5	None	-190	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		CHEMBL311473	111990	5	None	-190	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cc(CCc2c[nH]cn2)ccn1	10.1021/jm049932u
		24853662	102850	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	3	0	5	3.1	CN1CCN(c2nc3ccccc3nc2OC2CCCCC2)CC1	10.1021/jm7014217
		CHEMBL260043	102850	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	3	0	5	3.1	CN1CCN(c2nc3ccccc3nc2OC2CCCCC2)CC1	10.1021/jm7014217
		54584378	69933	0	None	-50	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774595	69933	0	None	-50	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789782	69933	0	None	-50	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		164626153	193157	0	None	-6456	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4875600	193157	0	None	-6456	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
		54583874	68320	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N)nc(N3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770986	68320	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N)nc(N3CCCC3)n2)CC1	10.1016/j.bmcl.2011.03.017
		54584378	69933	0	None	-50	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774595	69933	0	None	-50	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789782	69933	0	None	-50	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CC/C=C/CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		46890122	14145	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	421	9	2	5	4.3	Cc1cc(OCCCNCCc2cn(C)cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086344	14145	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	421	9	2	5	4.3	Cc1cc(OCCCNCCc2cn(C)cn2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		155568016	182817	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	4	1	6	1.1	CCC(CC)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4590367	182817	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	4	1	6	1.1	CCC(CC)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		58227319	123904	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393540	123904	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		56849571	78388	0	None	-117	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	401	8	2	5	4.5	O=[N+]([O-])c1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923034	78388	0	None	-117	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	401	8	2	5	4.5	O=[N+]([O-])c1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963347	78388	0	None	-117	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	401	8	2	5	4.5	O=[N+]([O-])c1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		25179126	180192	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm800876b
		CHEMBL452849	180192	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm800876b
		25179126	180192	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm901379s
		CHEMBL452849	180192	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)o1	10.1021/jm901379s
		164609729	191877	0	None	-2187	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856059	191877	0	None	-2187	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		164622886	192721	0	None	-131	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4869389	192721	0	None	-131	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		164626509	193114	0	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	358	3	4	4	3.2	N/C(=N\C(=O)NC1CCCCC1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4874969	193114	0	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	358	3	4	4	3.2	N/C(=N\C(=O)NC1CCCCC1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		11043445	63253	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL1632410	63253	1	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		1204	8713	119	None	-12	25	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	8713	119	None	-12	25	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	8713	119	None	-12	25	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	8713	119	None	-12	25	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	8713	119	None	-12	25	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	8713	119	None	-12	25	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		11609325	21302	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.3	CN1CCN(C(=O)c2nc3c(Cl)cc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL120221	21302	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.3	CN1CCN(C(=O)c2nc3c(Cl)cc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		24825796	74870	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	NC[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914744	74870	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	NC[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		46228100	206795	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	315	4	1	6	2.1	CN1CCN(c2cc(SCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595413	206795	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	315	4	1	6	2.1	CN1CCN(c2cc(SCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		44628631	74899	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3c(Cl)cc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914773	74899	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3c(Cl)cc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		71525679	96501	0	None	-9	6	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	96501	0	None	-9	6	Rat	6.9	pKi	=	6.9	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		4060730	26151	56	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL129199	26151	56	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		24853594	102912	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	4	0	5	3.3	Cc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL260470	102912	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	4	0	5	3.3	Cc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		44414495	86794	0	None	-34	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	5	0	2	6.3	CC1CC(C)CN(Cc2ccc(-c3ccc(CN4CC(C)CC(C)C4)cc3)cc2)C1	10.1016/j.bmc.2008.10.029
		CHEMBL212869	86794	0	None	-34	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	5	0	2	6.3	CC1CC(C)CN(Cc2ccc(-c3ccc(CN4CC(C)CC(C)C4)cc3)cc2)C1	10.1016/j.bmc.2008.10.029
		127026017	144136	0	None	-12	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752972	144136	0	None	-12	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1	10.1016/j.bmcl.2015.12.035
		164614907	191363	0	None	-436	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848697	191363	0	None	-436	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1	10.1016/j.ejmech.2021.113190
		57390263	74962	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	330	1	2	7	1.8	Nc1nc(N2CC3CCNC3C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915052	74962	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	330	1	2	7	1.8	Nc1nc(N2CC3CCNC3C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		9900313	26196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL129444	26196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9900313	26196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129444	26196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0341047
		1278	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		1279	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		4908365	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		CHEMBL129198	8931	84	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		46890592	13164	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082296	13164	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		9900313	26196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129444	26196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3cc(F)cc(F)c3[nH]2)CC1	10.1021/jm0502081
		156013896	185019	0	None	-7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4635634	185019	0	None	-7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650570	185019	0	None	-7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	401	9	1	2	5.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		25129523	194066	45	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL492884	194066	45	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		1249	8790	16	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		13499360	8790	16	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		CHEMBL90019	8790	16	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	139	4	2	2	0.7	NCCCCc1cnc[nH]1	10.1021/jm049932u
		1204	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1247	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		1375	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		774	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		CHEMBL90	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		DB05381	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorInhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030905y
		137655927	165667	0	None	17	2	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	403	7	2	3	5.2	O=C(NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		CHEMBL4095224	165667	0	None	17	2	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	403	7	2	3	5.2	O=C(NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		71603141	96495	0	None	14	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	5	1.2	CCc1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376795	96495	0	None	14	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	5	1.2	CCc1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		54585779	68325	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770991	68325	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		25179303	196125	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCCC3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL512568	196125	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCCC3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		51354304	65670	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCn2cc(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688972	65670	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCn2cc(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		71519016	93244	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314501	93244	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		71518859	93270	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	294	2	3	5	1.6	Nc1nc(N2CCNCC2)c2cc(-c3ccccc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314772	93270	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	294	2	3	5	1.6	Nc1nc(N2CCNCC2)c2cc(-c3ccccc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		156014317	185056	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	575	10	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/C=C/c3ccc(N(C)C)cc3)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634728	185056	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	575	10	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/C=C/c3ccc(N(C)C)cc3)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650854	185056	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	575	10	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/C=C/c3ccc(N(C)C)cc3)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		11724853	103795	0	None	-19	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	340	0	0	4	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C)c3ccccc32)CC1	10.1021/jm051008s
		CHEMBL266723	103795	0	None	-19	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	340	0	0	4	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C)c3ccccc32)CC1	10.1021/jm051008s
		57398985	74658	0	None	-1122	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910385	74658	0	None	-1122	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		118725539	123887	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	2	0	4	1.8	CN1CCN(c2ccnc(N3CCCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393523	123887	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	2	0	4	1.8	CN1CCN(c2ccnc(N3CCCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		16082822	86755	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@@H]2C[C@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL212705	86755	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@@H]2C[C@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		46228160	206638	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	308	3	0	6	1.6	CN1CCN(c2ncnc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594468	206638	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	308	3	0	6	1.6	CN1CCN(c2ncnc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		2306318	93783	12	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1039/C5MD00022J
		CHEMBL232421	93783	12	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1039/C5MD00022J
		127036980	144124	0	None	-16	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752885	144124	0	None	-16	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		57391033	74895	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	287	1	2	6	1.5	Nc1nc(N2CCNCC2)c2oc3cccc(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914769	74895	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	287	1	2	6	1.5	Nc1nc(N2CCNCC2)c2oc3cccc(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		1236	8848	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		1237	8848	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		156615	8848	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		CHEMBL268229	8848	25	None	-204	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm0341047
		24797248	206645	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594490	206645	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	324	2	1	6	1.4	CN1CCN(c2cc(N3CCc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		9951970	12272	1	None	-81	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1076300	12272	1	None	-81	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL154797	12272	1	None	-81	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		121238066	173471	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	2	8	-1.0	CN1CCN(c2nc(N)nc(CN3C(=O)NC(C)(C)C3=O)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4282283	173471	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	2	8	-1.0	CN1CCN(c2nc(N)nc(CN3C(=O)NC(C)(C)C3=O)n2)CC1	10.1016/j.ejmech.2017.09.035
		10860228	123613	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL338001	123613	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0341047
		10860228	123613	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338001	123613	1	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3ccc(Br)cc3[nH]2)CC1	10.1021/jm0502081
		3840250	143395	16	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	5	2.4	Cc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		CHEMBL3739776	143395	16	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	5	2.4	Cc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		56851447	78400	0	None	-144	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	424	7	2	3	5.9	Clc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1923026	78400	0	None	-144	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	424	7	2	3	5.9	Clc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1963433	78400	0	None	-144	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	424	7	2	3	5.9	Clc1ccc(C/N=C(/NC2CCCCC2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		90645157	118961	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1Cl	10.1016/j.ejmech.2014.06.032
		CHEMBL3290584	118961	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1Cl	10.1016/j.ejmech.2014.06.032
		2971762	200006	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL523617	200006	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		44450401	162910	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	3	2	4	2.0	O=c1[nH]c2ccc(Cl)cc2nc1NCN1CCCC1	10.1021/jm7014217
		CHEMBL406345	162910	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	278	3	2	4	2.0	O=c1[nH]c2ccc(Cl)cc2nc1NCN1CCCC1	10.1021/jm7014217
		2971762	200006	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL523617	200006	4	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	347	5	1	5	3.0	CN1CCN(c2nc(NCCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		164622190	192395	0	None	-93	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4864067	192395	0	None	-93	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCCc1ccccc1	10.1016/j.ejmech.2021.113190
		54586762	68301	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	4	2	5	2.0	CN1CCN(c2cc(N)nc(NCc3ccccc3)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770967	68301	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	4	2	5	2.0	CN1CCN(c2cc(N)nc(NCc3ccccc3)c2)CC1	10.1016/j.bmcl.2011.03.017
		136066109	207213	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	289	6	2	2	3.7	Cc1[nH]cnc1[C@@H]1C[C@H]1CCNCc1ccc(Cl)cc1	10.1016/j.bmc.2009.12.046
		46231557	207213	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	289	6	2	2	3.7	Cc1[nH]cnc1[C@@H]1C[C@H]1CCNCc1ccc(Cl)cc1	10.1016/j.bmc.2009.12.046
		CHEMBL598291	207213	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	289	6	2	2	3.7	Cc1[nH]cnc1[C@@H]1C[C@H]1CCNCc1ccc(Cl)cc1	10.1016/j.bmc.2009.12.046
		5477514	17152	1	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	408	4	4	5	2.6	C/N=C(\N)N/N=C(/C)c1ccc2sc3ccc(/C(C)=N\N/C(N)=N/C)cc3c2c1	10.1021/jm7014777
		CHEMBL1162345	17152	1	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	408	4	4	5	2.6	C/N=C(\N)N/N=C(/C)c1ccc2sc3ccc(/C(C)=N\N/C(N)=N/C)cc3c2c1	10.1021/jm7014777
		24826083	74922	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914797	74922	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		10988959	124886	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL340740	124886	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		4906599	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL436381	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		10988959	124886	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL340740	124886	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0341047
		4906599	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL436381	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0341047
		57391819	76511	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935570	76511	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)c1	10.1016/j.bmcl.2011.10.104
		53233801	68319	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770985	68319	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		10988959	124886	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL340740	124886	4	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		4906599	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL436381	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		71519674	96504	0	None	-1	5	Mouse	7.8	pKi	=	7.8	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	96504	0	None	-1	5	Mouse	7.8	pKi	=	7.8	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		56835171	76515	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		CHEMBL1935574	76515	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2013.02.091
		71603138	96492	0	None	32	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	2	5	1.9	CNC1CN(c2nc(N)nc3cc(C(C)(C)C)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376792	96492	0	None	32	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	2	5	1.9	CNC1CN(c2nc(N)nc3cc(C(C)(C)C)ccc23)C1	10.1016/j.bmcl.2013.02.091
		25128822	194260	0	None	-10	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		CHEMBL494093	194260	0	None	-10	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		44129214	205980	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	538	7	2	7	3.7	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Br)c(Cl)cc3n2)CC1	10.1021/jm901379s
		CHEMBL589782	205980	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	538	7	2	7	3.7	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Br)c(Cl)cc3n2)CC1	10.1021/jm901379s
		136192874	63257	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632414	63257	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		25147772	180188	9	None	1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452847	180188	9	None	1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		136192874	63257	0	None	-1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632414	63257	0	None	-1	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1204	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		1247	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		1375	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		774	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		CHEMBL90	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		DB05381	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C5MD00022J
		1223	7740	41	None	-60	11	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		1204	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		1247	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		1375	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		774	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		CHEMBL90	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		DB05381	8713	119	None	-3	25	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm201042n
		1278	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		1279	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		4908365	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		CHEMBL129198	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm201042n
		10967174	26214	3	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL129540	26214	3	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70681963	82462	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	2	1	2	2.9	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047470	82462	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	2	1	2	2.9	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		4906599	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL436381	175441	11	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1278	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		1279	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		4908365	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		CHEMBL129198	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014217
		3035746	194959	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL1237146	194959	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL498770	194959	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		45269820	202128	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202326	202128	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL551790	202128	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	308	6	3	3	3.5	N=C(NCc1cccc(Cl)c1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1278	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		1279	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		4908365	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		CHEMBL129198	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm051008s
		155491015	183274	4	None	-15	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4441731	183274	4	None	-15	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4596734	183274	4	None	-15	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		25129525	194362	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1039/C2MD20212C
		CHEMBL494648	194362	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	299	3	1	6	1.5	COc1ccc(-c2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1039/C2MD20212C
		46228125	206767	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595215	206767	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	366	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(Cl)c(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46890020	14140	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	8	3	4	4.5	Cc1cc(OCCCNCC2CCCCN2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086327	14140	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	8	3	4	4.5	Cc1cc(OCCCNCC2CCCCN2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		42641407	206165	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(Cl)cc(Cl)cc3n2)CC1	10.1021/jm901379s
		CHEMBL591013	206165	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(Cl)cc(Cl)cc3n2)CC1	10.1021/jm901379s
		127036981	144228	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753621	144228	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		135570464	185876	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	1	5	1.7	CN1CCN(c2nc(O)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL471712	185876	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	1	5	1.7	CN1CCN(c2nc(O)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		51354297	65660	0	None	-5	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	289	6	1	6	0.4	CN1CCN(Cc2cn(CCCc3c[nH]cn3)nn2)CC1	10.1021/jm1013488
		CHEMBL1688943	65660	0	None	-5	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	289	6	1	6	0.4	CN1CCN(Cc2cn(CCCc3c[nH]cn3)nn2)CC1	10.1021/jm1013488
		46890074	13375	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	403	8	1	3	6.2	Cc1cc(OCCCCCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083160	13375	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	403	8	1	3	6.2	Cc1cc(OCCCCCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		10107667	69939	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774599	69939	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789800	69939	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		25178755	183653	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCC[C@H]3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL461537	183653	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	5	2.6	CNc1nc(N2CCN3CCC[C@H]3C2)nc2ccc(Cl)cc12	10.1021/jm800876b
		24759518	186088	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL473302	186088	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	277	1	1	5	1.6	CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		1267	10576	49	None	-33	27	Human	6.8	pKi	=	6.8	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.8	pKi	=	6.8	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.8	pKi	=	6.8	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		118720439	122697	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	246	2	2	4	2.2	Nc1nc(C2CCCC2)cc(C2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354817	122697	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	246	2	2	4	2.2	Nc1nc(C2CCCC2)cc(C2CCNCC2)n1	10.1016/j.bmcl.2014.10.013
		24853527	174206	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	4	0	6	3.2	CN1CCN(c2nc3ccccc3nc2Oc2cccc(N(C)C)c2)CC1	10.1021/jm7014217
		CHEMBL429691	174206	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	4	0	6	3.2	CN1CCN(c2nc3ccccc3nc2Oc2cccc(N(C)C)c2)CC1	10.1021/jm7014217
		10107667	69939	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774599	69939	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789800	69939	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	279	7	2	3	3.0	O=C(NCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		10760516	69946	0	None	-9	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774598	69946	0	None	-9	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789829	69946	0	None	-9	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		127050431	147093	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806206	147093	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		10760516	69946	0	None	-9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774598	69946	0	None	-9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789829	69946	0	None	-9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	7	2	3	1.9	O=C(NCCC1CC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		57391034	74919	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914794	74919	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		57396299	74884	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	1	1	6	2.0	CN1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914758	74884	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	1	1	6	2.0	CN1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		57396300	74901	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	305	1	2	6	1.6	Nc1nc(N2CCNCC2)c2oc3ccc(F)c(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914775	74901	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	305	1	2	6	1.6	Nc1nc(N2CCNCC2)c2oc3ccc(F)c(F)c3c2n1	10.1016/j.bmcl.2011.08.014
		46228161	206679	14	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	233	1	2	6	-0.3	CN1CCN(c2nc(N)nc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594694	206679	14	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	233	1	2	6	-0.3	CN1CCN(c2nc(N)nc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		1223	7740	41	None	-363	11	Mouse	6.8	pKi	=	6.8	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-363	11	Mouse	6.8	pKi	=	6.8	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-363	11	Mouse	6.8	pKi	=	6.8	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		10023327	175795	0	None	-144	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11615601	81795	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	1	2	3.0	c1nc(CCCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL203390	81795	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	1	2	3.0	c1nc(CCCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		11600849	147322	0	None	-31	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL381074	147322	0	None	-31	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		66572108	82415	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3c(O)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047266	82415	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3c(O)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		9965450	82421	3	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3ccc(Cl)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047272	82421	3	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3ccc(Cl)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		45268970	202962	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	318	8	3	4	2.9	COc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202325	202962	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	318	8	3	4	2.9	COc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL561369	202962	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	318	8	3	4	2.9	COc1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		45267238	203009	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	345	7	4	2	3.5	N=C(NC=C(c1ccccc1)c1ccccc1)NCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL561651	203009	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	345	7	4	2	3.5	N=C(NC=C(c1ccccc1)c1ccccc1)NCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1204	8713	119	None	-3	25	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	6.8	pKi	=	6.8	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		127050019	147543	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	233	2	2	5	0.3	CN[C@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1039/C6MD00108D
		CHEMBL3818355	147543	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	233	2	2	5	0.3	CN[C@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1039/C6MD00108D
		1194	6834	3	None	-1318	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
		23786499	6834	3	None	-1318	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
		CHEMBL26116	6834	3	None	-1318	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
		127035835	144063	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752270	144063	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		70690368	82453	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	1	1	2	2.3	Cc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047461	82453	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	1	1	2	2.3	Cc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		24854707	103070	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	338	3	0	5	3.3	CN1CCN(c2nc3ccccc3nc2Oc2ccc(F)cc2)CC1	10.1021/jm7014217
		CHEMBL261222	103070	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	338	3	0	5	3.3	CN1CCN(c2nc3ccccc3nc2Oc2ccc(F)cc2)CC1	10.1021/jm7014217
		57390224	74652	0	None	-776	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910379	74652	0	None	-776	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		4905344	42110	9	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2cc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL1437043	42110	9	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1ccc2cc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1016/j.ejmech.2012.06.016
		70690367	82451	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	3	2.0	COc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047459	82451	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	3	2.0	COc1cccc2cc(C(=O)N3CCCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		59777309	116931	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.3	CN[C@@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1021/jm401727m
		CHEMBL3236581	116931	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.3	CN[C@@H]1CCN(c2nc(N)nc3c2CCC3)C1	10.1021/jm401727m
		57400777	74984	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915345	74984	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		56835171	76515	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	76515	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		3035746	194959	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL1237146	194959	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL498770	194959	9	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		53378928	122692	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	289	4	2	5	1.4	CN[C@@H]1CCN(c2cc(CCC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354812	122692	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	289	4	2	5	1.4	CN[C@@H]1CCN(c2cc(CCC(F)(F)F)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		44547564	123895	2	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	2.2	CN1CCN(c2ccnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393531	123895	2	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	2.2	CN1CCN(c2ccnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		57400777	74984	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915345	74984	0	None	426	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	1	2	2.5	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		57400738	74959	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.5	Nc1nc(N2CC[C@@H](N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915049	74959	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.5	Nc1nc(N2CC[C@@H](N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		56851445	78416	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	8	2	3	3.8	CCCCN/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923025	78416	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	8	2	3	3.8	CCCCN/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963551	78416	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	8	2	3	3.8	CCCCN/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		71603194	96497	0	None	35	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	3	2	5	1.6	CCc1ccc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376797	96497	0	None	35	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	3	2	5	1.6	CCc1ccc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		45257133	206683	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594721	206683	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		155540438	179320	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4483783	179320	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		57394625	75092	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	325	7	2	6	1.7	COc1ccccc1Cn1ccc(NCCc2cnc[nH]2)nc1=O	10.1016/j.bmcl.2011.07.114
		CHEMBL1916493	75092	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	325	7	2	6	1.7	COc1ccccc1Cn1ccc(NCCc2cnc[nH]2)nc1=O	10.1016/j.bmcl.2011.07.114
		124087	8171	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	8171	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	8171	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	8171	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	8171	114	None	-5888	15	Human	4.8	pKi	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		54587791	68317	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770983	68317	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		10515050	13021	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCCC(C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1081541	13021	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCCC(C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL350478	13021	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.5	CCCC(C)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		73355143	98645	0	None	-22	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	323	8	2	4	2.8	O=C(NCCOc1ccccc1Cl)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL2413362	98645	0	None	-22	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	323	8	2	4	2.8	O=C(NCCOc1ccccc1Cl)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		56678756	72403	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4	ChEMBL	391	5	1	4	4.2	CCC(=O)N[C@@H]1CC[C@H](C(=O)N(C)c2ccc(-c3nc4ccccc4o3)cc2)C1	10.6019/CHEMBL5212743
		CHEMBL1834199	72403	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4Selectivity interaction (GPCR panel (PDSP screen)) EUB0000738a HRH4	ChEMBL	391	5	1	4	4.2	CCC(=O)N[C@@H]1CC[C@H](C(=O)N(C)c2ccc(-c3nc4ccccc4o3)cc2)C1	10.6019/CHEMBL5212743
		137634349	162794	0	None	-741	2	Human	4.8	pKi	=	4.8	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	6	0	3	4.7	CC(=O)c1ccc(OCc2ccc(CN3CCCC(C)C3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4062122	162794	0	None	-741	2	Human	4.8	pKi	=	4.8	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	6	0	3	4.7	CC(=O)c1ccc(OCc2ccc(CN3CCCC(C)C3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		164626370	193252	0	None	-14	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	6	4	4	1.8	CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		CHEMBL4876799	193252	0	None	-14	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	6	4	4	1.8	CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		155568977	182931	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	281	6	3	3	2.6	c1ccc2[nH]c(CNCC[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		CHEMBL4592695	182931	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	281	6	3	3	2.6	c1ccc2[nH]c(CNCC[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		24854706	102753	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)c(Cl)c2)CC1	10.1021/jm7014217
		CHEMBL259536	102753	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	388	3	0	5	4.5	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)c(Cl)c2)CC1	10.1021/jm7014217
		1278	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		1279	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		4908365	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		CHEMBL129198	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		46929554	23526	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	349	5	1	3	4.7	FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243367	23526	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	349	5	1	3	4.7	FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		4060730	26151	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129199	26151	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		49841608	76506	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935565	76506	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	321	1	1	5	1.7	CN1CCN(c2nc(N)nc3cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		1278	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		1279	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		4908365	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		CHEMBL129198	8931	84	None	-3	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm7014777
		4060730	26151	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129199	26151	56	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0502081
		45379805	206207	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	7	1.9	CN1CCN(c2nc(NCCS(=O)(=O)N3CCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591248	206207	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	7	1.9	CN1CCN(c2nc(NCCS(=O)(=O)N3CCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		164585473	191341	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to H4 receptor (unknown origin)Binding affinity to H4 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4848380	191341	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to H4 receptor (unknown origin)Binding affinity to H4 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		71519177	93259	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314760	93259	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		112936262	144054	1	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752195	144054	1	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		1403136	187288	9	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL475331	187288	9	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm901379s
		164611143	191495	0	None	-75	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	414	6	4	4	2.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F	10.1016/j.ejmech.2021.113190
		CHEMBL4850448	191495	0	None	-75	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	414	6	4	4	2.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F	10.1016/j.ejmech.2021.113190
		137646744	164599	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	391	10	1	5	3.0	O=C(CCNC(=O)C(Cc1ccccc1)Cn1ccnc1)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4083336	164599	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	391	10	1	5	3.0	O=C(CCNC(=O)C(Cc1ccccc1)Cn1ccnc1)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		56835171	76515	0	None	-10	9	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from rat H4RDisplacement of [3H]histamine from rat H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	76515	0	None	-10	9	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from rat H4RDisplacement of [3H]histamine from rat H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		90645149	118951	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1cccc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290574	118951	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1cccc(-c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2014.06.032
		46890021	14141	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.8	Cc1cc(OCCCNCC2CCCCN2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086328	14141	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.8	Cc1cc(OCCCNCC2CCCCN2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		118725541	123892	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	1	4	2.0	CCCCNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393528	123892	2	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	1	4	2.0	CCCCNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		16082858	86867	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL213133	86867	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		45379809	206168	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	420	5	1	8	2.1	CN1CCN(c2nc(NCCN3C(=O)CSC3=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591027	206168	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	420	5	1	8	2.1	CN1CCN(c2nc(NCCN3C(=O)CSC3=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		135398737	7745	93	None	-57	90	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		38	7745	93	None	-57	90	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		722	7745	93	None	-57	90	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		CHEMBL42	7745	93	None	-57	90	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		DB00363	7745	93	None	-57	90	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm051008s
		10575070	74656	0	None	-79	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	439	7	1	3	4.7	O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910383	74656	0	None	-79	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	439	7	1	3	4.7	O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2011.09.001
		164622330	192641	0	None	-724	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4867962	192641	0	None	-724	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		1267	10576	49	None	-33	27	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		3035905	10576	49	None	-33	27	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		CHEMBL260374	10576	49	None	-33	27	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.6b00120
		122193098	130695	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628045	130695	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		90645162	118966	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	324	2	1	6	1.3	CN1CCN(c2nc(N)nc(-c3cc(F)c(F)c(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290589	118966	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	324	2	1	6	1.3	CN1CCN(c2nc(N)nc(-c3cc(F)c(F)c(F)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		24745507	74995	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915538	74995	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	302	5	3	6	1.2	CNC1CN(c2cc(NCc3cccc(F)c3)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		45257133	206683	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594721	206683	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccccc3Cl)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		24826165	74889	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914763	74889	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	1	1	6	2.8	CN1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		1278	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		1279	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		4908365	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		CHEMBL129198	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		3032915	22267	24	None	-1	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1021/jm0341047
		CHEMBL12160	22267	24	None	-1	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1021/jm0341047
		127052294	147080	0	None	5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806079	147080	0	None	5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		57394550	74891	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	2	1	7	2.2	COc1ccc2c(c1)sc1c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.08.014
		CHEMBL1914765	74891	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	2	1	7	2.2	COc1ccc2c(c1)sc1c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.08.014
		51354009	65657	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cc2cn(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688940	65657	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cc2cn(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		156011119	183901	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	841	18	4	6	8.7	Cc1cc(OCCCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6ccc[nH]6)n5[B-]4(F)F)C=C3)cc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4633688	183901	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	841	18	4	6	8.7	Cc1cc(OCCCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6ccc[nH]6)n5[B-]4(F)F)C=C3)cc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		51354296	65659	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	274	6	1	5	1.6	c1nc(CCCn2cc(CN3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688942	65659	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	274	6	1	5	1.6	c1nc(CCCn2cc(CN3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		1236	8848	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		1237	8848	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		156615	8848	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		CHEMBL268229	8848	25	None	-204	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1021/jm7014777
		756701	206596	33	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	218	1	1	5	0.1	CN1CCN(c2ncnc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594152	206596	33	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	218	1	1	5	0.1	CN1CCN(c2ncnc3[nH]cnc23)CC1	10.1016/j.bmc.2009.08.059
		63868328	181030	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4549015	181030	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	3	1	6	0.2	CCCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		58227381	183395	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.3	CC(C)(C)CNc1nccc(N2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4513989	183395	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.3	CC(C)(C)CNc1nccc(N2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597817	183395	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.3	CC(C)(C)CNc1nccc(N2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		25128822	194260	0	None	-10	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL494093	194260	0	None	-10	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		25179124	181012	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm800876b
		CHEMBL454883	181012	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm800876b
		25179122	200052	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL523941	200052	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25179124	181012	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm901379s
		CHEMBL454883	181012	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	371	4	1	6	3.5	Cc1cc(Cl)cc2c(NCc3ccco3)nc(N3CCN(C)CC3)nc12	10.1021/jm901379s
		25179122	200052	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL523941	200052	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	403	4	1	5	3.9	CN1CCN(c2nc(NCc3ccc(F)c(F)c3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		1265	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		6422124	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		CHEMBL14638	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		24994634	8923	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	8923	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	8923	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from rat histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		24994634	8923	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat recombinant histamine H4 receptorDisplacement of [3H]histamine from rat recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	8923	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat recombinant histamine H4 receptorDisplacement of [3H]histamine from rat recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	8923	31	None	-21	7	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from rat recombinant histamine H4 receptorDisplacement of [3H]histamine from rat recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL4520788	220754	10	None	-89	25	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HRH4Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HRH4	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		54581937	68297	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	3	1	5	1.3	CC(C)N(C)c1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770963	68297	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	3	1	5	1.3	CC(C)N(C)c1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		137646939	164517	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	335	5	3	4	3.6	CC(C)(CN=C(c1ccccc1O)c1ccccc1O)c1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		CHEMBL4082297	164517	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	335	5	3	4	3.6	CC(C)(CN=C(c1ccccc1O)c1ccccc1O)c1c[nH]cn1	10.1016/j.ejmech.2016.09.074
		9878733	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL338051	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9878733	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL338051	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0341047
		49841610	76507	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3cc(-c4ccccc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935566	76507	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3cc(-c4ccccc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		44547127	122696	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		44547127	122696	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3354816	122696	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354816	122696	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	234	4	2	4	1.7	CN[C@@H]1CCN(c2ccnc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		24739219	74828	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	289	1	2	6	1.8	Nc1nc(N2CC(N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914546	74828	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	289	1	2	6	1.8	Nc1nc(N2CC(N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		24826265	74887	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.3	CN1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914761	74887	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.3	CN1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)CC1	10.1016/j.bmcl.2011.08.014
		9992865	121204	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL333220	121204	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	262	1	1	3	1.1	CN1CCN(C(=O)c2nc3cc(F)ccc3[nH]2)CC1	10.1021/jm0502081
		9878733	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338051	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1021/jm0502081
		2063135	15150	9	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL1093180	15150	9	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2010.02.097
		44129213	206162	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)c(Cl)cc3n2)CC1	10.1021/jm901379s
		CHEMBL590995	206162	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)c(Cl)cc3n2)CC1	10.1021/jm901379s
		71525681	96503	0	None	-2	6	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	96503	0	None	-2	6	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		136141537	63255	3	None	2	3	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632412	63255	3	None	2	3	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		136030655	63256	0	None	-2	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632413	63256	0	None	-2	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1278	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		1279	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		4908365	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		CHEMBL129198	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2004.08.035
		1251	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		3035842	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		CHEMBL18661	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		1251	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		3035842	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		CHEMBL18661	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		1251	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm201042n
		3035842	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm201042n
		CHEMBL18661	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm201042n
		11673377	146040	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	263	7	2	2	3.2	Clc1ccc(CNCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		CHEMBL379027	146040	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	263	7	2	2	3.2	Clc1ccc(CNCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		25129523	194066	45	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL492884	194066	45	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		66572114	82425	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047276	82425	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70690369	82465	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	1	2	2	2.0	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047473	82465	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	281	1	2	2	2.0	O=C(c1cc2cc(Cl)cc(F)c2[nH]1)N1CCNCC1	10.1016/j.ejmech.2012.06.016
		9878733	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL338051	123622	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3cccc(Cl)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1204	8713	119	None	-3	25	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		1247	8713	119	None	-3	25	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		1375	8713	119	None	-3	25	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		774	8713	119	None	-3	25	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		CHEMBL90	8713	119	None	-3	25	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		DB05381	8713	119	None	-3	25	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C2MD20212C
		1278	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		1279	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		4908365	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		CHEMBL129198	8931	84	None	-3	8	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		11846298	146059	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
		CHEMBL379102	146059	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccc(F)cc32)CC1	10.1021/jm051008s
		155538989	183108	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	3	5	2.1	CC(C)(C)CNc1nccc(NC2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4513421	183108	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	3	5	2.1	CC(C)(C)CNc1nccc(NC2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595438	183108	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	3	5	2.1	CC(C)(C)CNc1nccc(NC2CCNCC2)n1	10.1021/acs.jmedchem.9b01342
		164608815	191233	0	None	-47	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4846638	191233	0	None	-47	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
		164611342	191867	0	None	-416	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856005	191867	0	None	-416	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
		155513612	183099	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-2	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		156015838	185025	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	373	7	1	2	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4640263	185025	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	373	7	1	2	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650622	185025	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	373	7	1	2	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		127036982	144245	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	525	6	1	6	5.9	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753784	144245	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	525	6	1	6	5.9	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1	10.1016/j.bmcl.2015.12.035
		57393769	74945	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	281	1	2	6	1.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915030	74945	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	281	1	2	6	1.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		11688307	76678	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938968	76678	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	318	2	1	3	2.2	CCN1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		136141537	63255	3	None	-10	3	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632412	63255	3	None	-10	3	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		44395364	73673	0	None	15	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	276	2	1	2	3.3	CN1CCC(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL186456	73673	0	None	15	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	276	2	1	2	3.3	CN1CCC(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		10037650	11981	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106158	11981	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		135398737	7745	93	None	-57	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		38	7745	93	None	-57	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		722	7745	93	None	-57	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		CHEMBL42	7745	93	None	-57	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		DB00363	7745	93	None	-57	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm201042n
		11572015	81805	0	None	-50	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	9	2	2	2.5	CCCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL203441	81805	0	None	-50	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	9	2	2	2.5	CCCCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		11600780	82824	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	2	2	1.7	CC(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205732	82824	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	2	2	1.7	CC(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		1408942	71897	4	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL1824046	71897	4	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.06.123
		4060730	26151	56	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL129199	26151	56	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		25129527	194193	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL493720	194193	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		66573462	82445	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	2	2	2	2.2	CNC1CN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047453	82445	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	2	2	2	2.2	CNC1CN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		767246	102792	5	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	242	1	0	4	1.7	Cc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL259745	102792	5	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	242	1	0	4	1.7	Cc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		155550732	183408	0	None	-794	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4540849	183408	0	None	-794	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4597895	183408	0	None	-794	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		11313837	9278	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		1254	9278	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		CHEMBL175782	9278	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmcl.2010.10.041
		11313837	9278	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		1254	9278	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		CHEMBL175782	9278	8	None	-1995	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptorDisplacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor	ChEMBL	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049475h
		71681480	96436	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	307	6	3	7	2.0	Nc1nc(NCCNc2ccncn2)cc(-c2ccccc2)n1	10.1021/jm301886t
		CHEMBL2375761	96436	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	307	6	3	7	2.0	Nc1nc(NCCNc2ccncn2)cc(-c2ccccc2)n1	10.1021/jm301886t
		57392460	76641	0	None	14	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL1938843	76641	0	None	14	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572104	82411	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ccncc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047262	82411	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ccncc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572112	82423	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3ccc([N+](=O)[O-])cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047274	82423	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3ccc([N+](=O)[O-])cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		44395361	73714	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	293	1	2	3	2.0	CN1CCN(C(=O)Nc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL186640	73714	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	293	1	2	3	2.0	CN1CCN(C(=O)Nc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		10879463	12062	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106570	12062	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		10945113	116406	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL322256	116406	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		127035836	144296	0	None	-5	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	4	1	5	3.9	Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3754176	144296	0	None	-5	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	4	1	5	3.9	Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		164618283	191323	0	None	-537	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	5	2.4	COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848026	191323	0	None	-537	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	5	2.4	COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		53233805	68298	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770964	68298	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.5	CC(C)CNc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		54585781	68335	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1771000	68335	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		118720442	122699	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	3	5	1.4	Nc1cc(N2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354820	122699	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	3	5	1.4	Nc1cc(N2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		44547268	123890	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393526	123890	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		58227255	123903	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393539	123903	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2ccnc(NCC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		58227252	123908	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393544	123908	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		25112105	14935	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1091875	14935	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24737949	74907	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914782	74907	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	2	2	6	1.9	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		24825996	74913	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914788	74913	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		59777341	116925	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	275	3	2	5	1.9	CN[C@@H]1CCN(c2cc(C3CCCCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236576	116925	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	275	3	2	5	1.9	CN[C@@H]1CCN(c2cc(C3CCCCC3)nc(N)n2)C1	10.1021/jm401727m
		1278	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		1279	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		4908365	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		CHEMBL129198	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		24745335	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		24745335	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	7083	12	None	4	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		53257796	116924	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236575	116924	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	3	2	5	1.1	CN[C@@H]1CCN(c2cc(C3CCC3)nc(N)n2)C1	10.1021/jm401727m
		24738269	74825	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.1	Nc1nc(N2CC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914543	74825	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	1	2	6	2.1	Nc1nc(N2CC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		1223	7740	41	None	-60	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor T5.42A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		44231735	14557	0	None	-1	4	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089390	14557	0	None	-1	4	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	301	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC32CCCC2)C1	10.1016/j.bmcl.2010.01.131
		44462956	12371	0	None	2	2	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL1077276	12371	0	None	2	2	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		1278	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1278	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		1279	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		1279	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		4908365	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		4908365	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		CHEMBL129198	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8005959
		CHEMBL129198	8931	84	None	3	8	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800670r
		137657169	166366	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	8	1	4	4.1	O=[N+]([O-])c1cccc(C(OCCCc2c[nH]cn2)c2ccccc2)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4102970	166366	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	337	8	1	4	4.1	O=[N+]([O-])c1cccc(C(OCCCc2c[nH]cn2)c2ccccc2)c1	10.1016/j.ejmech.2016.09.074
		59777258	116910	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236561	116910	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.5	Nc1nc(C2CCCC2)cc(N2C[C@H]3CCN[C@H]3C2)n1	10.1021/jm401727m
		25130914	194033	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL492677	194033	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		46890547	13288	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082772	13288	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	7	2	4	4.0	CNC1CCN(CCCOc2ccc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)c2)C1	10.1016/j.bmcl.2010.04.017
		10446295	8913	34	None	269	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm401727m
		1277	8913	34	None	269	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm401727m
		CHEMBL185951	8913	34	None	269	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm401727m
		68081305	116899	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	1	1	2	1.3	CN1CCN(C(=O)c2cc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		CHEMBL3236550	116899	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	1	1	2	1.3	CN1CCN(C(=O)c2cc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		24798144	116902	2	None	-19	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		CHEMBL3236553	116902	2	None	-19	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.1	Nc1nc(C2CCCC2)cc(N2CCNCC2)n1	10.1021/jm401727m
		24738103	74905	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(OC)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914780	74905	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	3	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(OC)c23)C1	10.1016/j.bmcl.2011.08.014
		24745335	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		24745335	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	7083	12	None	-6	5	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		16362	9899	71	None	-562	29	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		2172	9899	71	None	-562	29	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		90	9899	71	None	-562	29	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		CHEMBL1423	9899	71	None	-562	29	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		DB01100	9899	71	None	-562	29	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1016/j.ejmech.2016.09.074
		9904236	20848	22	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL1197564	20848	22	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46890589	13794	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	7	1	4	4.8	Cc1cc(OCCCN2CCCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084809	13794	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	7	1	4	4.8	Cc1cc(OCCCN2CCCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		57396382	75094	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	9	2	7	3.8	COCc1ccc(CN2CC[C@H](Nc3cc(NCCC(C)(C)C)ncn3)C2)o1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916495	75094	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	9	2	7	3.8	COCc1ccc(CN2CC[C@H](Nc3cc(NCCC(C)(C)C)ncn3)C2)o1	10.1016/j.bmcl.2011.07.114
		57391122	75095	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	7	3	6	3.9	CC(C)(C)CCNc1cc(N[C@H]2CCN(Cc3cccc(F)c3O)C2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916496	75095	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	387	7	3	6	3.9	CC(C)(C)CCNc1cc(N[C@H]2CCN(Cc3cccc(F)c3O)C2)ncn1	10.1016/j.bmcl.2011.07.114
		57394628	75100	1	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	4	2	5	1.7	CC(C)(C)CCNc1cc(N2CCNCC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916500	75100	1	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	4	2	5	1.7	CC(C)(C)CCNc1cc(N2CCNCC2)ncn1	10.1016/j.bmcl.2011.07.114
		57397738	76639	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	245	1	0	5	0.1	CN1CCN(C(=O)c2cn3ccncc3n2)CC1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938841	76639	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	245	1	0	5	0.1	CN1CCN(C(=O)c2cn3ccncc3n2)CC1	10.1016/j.bmcl.2011.11.098
		10399535	125219	3	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	2	2	1.6	CC1CN(C(=O)c2cc3ccccc3[nH]2)CCN1	10.1021/jm0341047
		CHEMBL341087	125219	3	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	243	1	2	2	1.6	CC1CN(C(=O)c2cc3ccccc3[nH]2)CCN1	10.1021/jm0341047
		90645147	118953	0	None	13	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290576	118953	0	None	13	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		155567108	183415	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	223	5	3	5	1.3	CC(C)(C)CNc1nccc(NCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4586599	183415	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	223	5	3	5	1.3	CC(C)(C)CNc1nccc(NCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597946	183415	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	223	5	3	5	1.3	CC(C)(C)CNc1nccc(NCCN)n1	10.1021/acs.jmedchem.9b01342
		155536509	183251	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	274	6	3	5	2.3	CC(C)(C)CNc1nccc(NCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4473753	183251	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	274	6	3	5	2.3	CC(C)(C)CNc1nccc(NCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596582	183251	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	274	6	3	5	2.3	CC(C)(C)CNc1nccc(NCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		4687476	103086	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL261320	103086	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		9928073	210428	0	None	-67	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL67284	210428	0	None	-67	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm051008s
		90654501	117086	0	None	-21877	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	314	6	0	5	3.1	Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238444	117086	0	None	-21877	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	314	6	0	5	3.1	Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		4687476	103086	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1021/jm7014217
		CHEMBL261320	103086	4	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2nccc3ccccc23)CC1	10.1021/jm7014217
		10879463	12062	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106570	12062	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		46228132	208924	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		CHEMBL609161	208924	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		46228071	206957	18	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL596562	206957	18	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		51354870	65678	0	None	-26	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	305	6	0	5	2.0	CN1CCN(CCCn2cc(CC3CCCCC3)nn2)CC1	10.1021/jm1013488
		CHEMBL1688981	65678	0	None	-26	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	305	6	0	5	2.0	CN1CCN(CCCn2cc(CC3CCCCC3)nn2)CC1	10.1021/jm1013488
		57391928	76684	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4ccc(Cl)nc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938973	76684	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4ccc(Cl)nc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		23650960	155908	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(F)ccc2[nH]1	nan
		CHEMBL3943309	155908	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(F)ccc2[nH]1	nan
		42624149	116917	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3236568	116917	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1016/j.bmcl.2014.10.013
		25218146	123885	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	2	0	4	2.6	CN1CCN(c2ccnc(-c3ccsc3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393521	123885	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	2	0	4	2.6	CN1CCN(c2ccnc(-c3ccsc3)c2)CC1	10.1016/j.bmcl.2014.12.027
		42624149	116917	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236568	116917	1	None	3	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		53258370	116918	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236569	116918	1	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CCc1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		57394548	74873	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@@H]3CCCN[C@@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914747	74873	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@@H]3CCCN[C@@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		57396298	74878	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	1	1	6	1.8	CN1CCN(c2nc(N)nc3c2oc2cccc(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914752	74878	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	301	1	1	6	1.8	CN1CCN(c2nc(N)nc3c2oc2cccc(F)c23)CC1	10.1016/j.bmcl.2011.08.014
		44628629	74893	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	269	1	2	6	1.4	Nc1nc(N2CCNCC2)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914767	74893	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	269	1	2	6	1.4	Nc1nc(N2CCNCC2)c2oc3ccccc3c2n1	10.1016/j.bmcl.2011.08.014
		11630326	79346	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		CHEMBL199231	79346	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	263	1	1	3	1.9	Cc1csc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		51354582	65672	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.3	CC(c1cn(CCCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		CHEMBL1688974	65672	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.3	CC(c1cn(CCCc2c[nH]cn2)nn1)C1CCCCC1	10.1021/jm1013488
		71603195	96498	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	3	2	5	1.9	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376798	96498	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	3	2	5	1.9	CN[C@@H]1CCN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		1251	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		3035842	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		CHEMBL18661	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1021/jm049932u
		1530	8963	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-21379	21	Human	4.7	pKi	=	4.7	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		57399107	74989	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1021/acs.jmedchem.5b00516
		CHEMBL1915532	74989	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1021/acs.jmedchem.5b00516
		57399107	74989	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915532	74989	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.125
		57399107	74989	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915532	74989	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	373	8	3	7	3.1	CC(C)(C)CCNc1cc(NC2CCN(Cc3ccc(CO)o3)C2)ncn1	10.1016/j.bmcl.2011.07.114
		57395619	74990	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915533	74990	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		57395619	74990	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915533	74990	14	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	309	3	1	5	1.8	CN1CCN(c2cc(NC3Cc4ccccc4C3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		168268680	199545	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5172675	199545	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221210	199545	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		1403136	187288	9	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL475331	187288	9	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)c3ccccc3n2)CC1	10.1021/jm800876b
		1204	8713	119	None	-15	25	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-15	25	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-15	25	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-15	25	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-15	25	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-15	25	Mouse	5.7	pKi	=	5.7	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		164610824	191889	0	None	-14	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	452	8	4	4	3.6	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856200	191889	0	None	-14	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	452	8	4	4	3.6	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		10945113	116406	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL322256	116406	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		21896704	166305	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	429	9	1	7	2.7	CC(=O)SCC(Cc1ccc2c(c1)OCO2)C(=O)NCC(=O)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4102243	166305	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	429	9	1	7	2.7	CC(=O)SCC(Cc1ccc2c(c1)OCO2)C(=O)NCC(=O)OCc1ccccc1	10.1016/j.ejmech.2016.09.074
		46912441	17674	0	None	-117	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	309	3	1	2	3.9	FC(F)(F)c1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		CHEMBL1172754	17674	0	None	-117	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	309	3	1	2	3.9	FC(F)(F)c1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		118725538	123886	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	3	1	4	2.6	CN[C@@H]1CCN(c2ccnc(-c3ccsc3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393522	123886	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	259	3	1	4	2.6	CN[C@@H]1CCN(c2ccnc(-c3ccsc3)c2)C1	10.1016/j.bmcl.2014.12.027
		1204	8713	119	None	-3	25	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	6.7	pKi	=	6.7	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		155567030	183196	0	None	-645	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4586133	183196	0	None	-645	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4596108	183196	0	None	-645	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		24854708	162502	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL405416	162502	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		51354587	65677	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	0	5	2.7	c1cn(CCCn2cc(CC3CCCCC3)nn2)cn1	10.1021/jm1013488
		CHEMBL1688979	65677	0	None	-3	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	0	5	2.7	c1cn(CCCn2cc(CC3CCCCC3)nn2)cn1	10.1021/jm1013488
		10702196	115345	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL320279	115345	1	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	165	2	2	3	0.4	NC[C@@H]1C=C[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		136016345	17156	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	377	5	4	6	2.1	CCOC(=O)c1ccc(NC2=CC(=O)/C(=N\NC(=N)N)c3ccccc32)cc1	10.1021/jm7014777
		CHEMBL1162352	17156	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	377	5	4	6	2.1	CCOC(=O)c1ccc(NC2=CC(=O)/C(=N\NC(=N)N)c3ccccc32)cc1	10.1021/jm7014777
		127052293	147016	3	None	34	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	147016	3	None	34	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1251	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmc.2010.04.052
		3035842	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmc.2010.04.052
		CHEMBL18661	8795	39	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	10.1016/j.bmc.2010.04.052
		11258459	91004	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		CHEMBL220933	91004	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1cc(C)c2nc(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)[nH]c2c1	10.1016/j.bmcl.2006.08.117
		46228082	209158	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	340	5	2	6	2.5	CC(C)c1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		CHEMBL610626	209158	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	340	5	2	6	2.5	CC(C)c1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		49841721	76499	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		CHEMBL1935558	76499	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		25178551	181010	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454882	181010	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm800876b
		25178551	181010	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL454882	181010	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	341	4	1	6	2.7	CN1CCN(c2nc(NCc3ccco3)c3cc(F)ccc3n2)CC1	10.1021/jm901379s
		45379807	206288	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	6	3.5	CN1CCN(c2nc(NCCC(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591970	206288	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	438	6	1	6	3.5	CN1CCN(c2nc(NCCC(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10037650	11981	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106158	11981	0	None	31	2	Human	6.7	pKi	=	6.7	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		122194624	130798	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccccc1/C=C/c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629827	130798	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccccc1/C=C/c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2015.08.014
		57400700	74653	0	None	-3090	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910380	74653	0	None	-3090	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		164610421	192039	0	None	-7	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	332	5	4	4	2.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4858567	192039	0	None	-7	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	332	5	4	4	2.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113190
		46890120	13309	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	416	6	1	4	5.2	Cc1cc(OCCCN2Cc3cccnc3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082851	13309	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	416	6	1	4	5.2	Cc1cc(OCCCN2Cc3cccnc3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		56851604	78404	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	8	2	3	5.1	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923028	78404	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	8	2	3	5.1	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963460	78404	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	8	2	3	5.1	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		24853663	102806	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	272	3	0	5	1.8	CCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL259839	102806	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	272	3	0	5	1.8	CCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		24278976	103026	61	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2nc3ccccc3nc2Cl)CC1	10.1021/jm7014217
		CHEMBL261010	103026	61	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2nc3ccccc3nc2Cl)CC1	10.1021/jm7014217
		24854704	102909	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		CHEMBL260456	102909	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		10923241	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128958	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		10923241	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128958	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0341047
		56835171	76515	0	None	-1	9	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from mouse H4RDisplacement of [3H]histamine from mouse H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	76515	0	None	-1	9	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from mouse H4RDisplacement of [3H]histamine from mouse H4R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		11687917	21737	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
		CHEMBL120854	21737	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	292	1	1	3	1.9	Cc1cc(Cl)c2nc(C(=O)N3CCN(C)CC3)[nH]c2c1	10.1021/jm0502081
		10923241	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128958	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1021/jm0502081
		45257131	206687	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		CHEMBL594731	206687	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		57403350	75097	0	None	35	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	3	1	5	1.7	CN1CCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916498	75097	0	None	35	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	3	1	5	1.7	CN1CCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		24804058	150875	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	424	7	2	5	5.1	Cc1c(F)ccc2[nH]c(-c3cnc(NCCCC4CCN(C)CC4)nc3C(C)C)nc12	nan
		CHEMBL3903520	150875	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	424	7	2	5	5.1	Cc1c(F)ccc2[nH]c(-c3cnc(NCCCC4CCN(C)CC4)nc3C(C)C)nc12	nan
		126963284	151552	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL3909134	151552	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	311	1	1	3	4.2	CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		46890675	14014	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	1	4	4.4	Cc1cc(OCCCN2CC3CCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1085803	14014	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	1	4	4.4	Cc1cc(OCCCN2CC3CCN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		49841722	76500	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3c(-c4ccc(C#N)cc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935559	76500	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3c(-c4ccc(C#N)cc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		168276867	199614	0	None	-4	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174278	199614	0	None	-4	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221653	199614	0	None	-4	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		24853598	102998	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	350	4	0	6	3.2	COc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL260851	102998	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	350	4	0	6	3.2	COc1ccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		24853596	103073	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	354	3	0	5	3.8	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		CHEMBL261225	103073	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	354	3	0	5	3.8	CN1CCN(c2nc3ccccc3nc2Oc2ccc(Cl)cc2)CC1	10.1021/jm7014217
		164610289	191912	0	None	-38	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	7	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856602	191912	0	None	-38	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	7	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		57399827	75101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916501	75101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2cc(NCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		90645155	118959	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290582	118959	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		90645155	118959	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL3290582	118959	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3ccc(C#N)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		46228114	206955	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL596551	206955	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	314	4	3	7	1.1	CN1CCN(c2cc(NCc3ccc(O)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		25178131	193717	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	381	5	1	5	3.7	CN1CCN(c2nc(NCCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL490072	193717	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	381	5	1	5	3.7	CN1CCN(c2nc(NCCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		90645152	118956	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	396	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(I)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290579	118956	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	396	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3ccc(I)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		49818718	76505	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935564	76505	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		54582867	68333	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770999	68333	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		25147771	181017	0	None	1	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454890	181017	0	None	1	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		11440060	213810	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	368	8	1	2	5.4	c1ccc(C(OCCCc2c[nH]cn2)(c2ccccc2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL91576	213810	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	368	8	1	2	5.4	c1ccc(C(OCCCc2c[nH]cn2)(c2ccccc2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		127051301	146978	0	None	5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	146978	0	None	5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		58227216	123918	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393554	123918	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		550981	75806	12	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	280	5	2	3	2.9	OC(CNC1CC1)Cn1c2ccccc2c2ccccc21	10.1021/jm2011589
		CHEMBL1923533	75806	12	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	280	5	2	3	2.9	OC(CNC1CC1)Cn1c2ccccc2c2ccccc21	10.1021/jm2011589
		24804056	157431	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	420	8	2	5	5.1	CCCc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(C)ccc2[nH]1	nan
		CHEMBL3955597	157431	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	420	8	2	5	5.1	CCCc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)c(C)ccc2[nH]1	nan
		71461658	85832	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	4	0.5	CN1CCN(C(=O)c2nc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL2113162	85832	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	259	1	2	4	0.5	CN1CCN(C(=O)c2nc3cc(N)ccc3[nH]2)CC1	10.1021/jm0502081
		4024	8796	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		9989505	8796	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		CHEMBL82298	8796	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1021/jm049932u
		122193101	130698	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.4	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C(F)(F)F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628048	130698	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.4	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C(F)(F)F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		155546701	180434	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	2	1	6	0.8	CN1CCN(c2nc(N)nc(CC(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4534504	180434	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	264	2	1	6	0.8	CN1CCN(c2nc(N)nc(CC(C)(C)C)n2)CC1	10.1016/j.bmc.2019.02.020
		24798596	206646	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594491	206646	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	310	2	1	6	1.3	CN1CCN(c2cc(N3Cc4ccccc4C3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		21193534	18037	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	292	7	1	2	4.1	c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL1179089	18037	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	292	7	1	2	4.1	c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL59679	18037	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	292	7	1	2	4.1	c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		54587789	68310	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(NCCO)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770976	68310	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	4	3	7	-0.8	CN1CCN(c2cc(NCCO)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		45257131	206687	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		CHEMBL594731	206687	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1ccccc1CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmc.2009.08.059
		90655027	116904	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236555	116904	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	3	2	5	1.5	CN[C@H]1CCN(c2cc(C3CCCC3)nc(N)n2)C1	10.1021/jm401727m
		66740898	116911	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
		CHEMBL3236562	116911	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	287	2	1	5	1.7	CN1C[C@H]2CN(c3cc(C4CCCC4)nc(N)n3)C[C@H]2C1	10.1021/jm401727m
		24826082	74916	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914791	74916	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)C1	10.1016/j.bmcl.2011.08.014
		11587279	131829	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL364400	131829	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3cc(Cl)sc3[nH]2)CC1	10.1021/jm0502081
		1226	8800	20	None	2	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
		41376	8800	20	None	2	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
		CHEMBL12608	8800	20	None	2	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1016/j.bmcl.2010.10.041
		10105117	110972	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL309819	110972	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	226	6	3	2	1.6	CC/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		10466840	211260	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CC/N=C(\S)NCCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL72424	211260	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	7	3	2	2.0	CC/N=C(\S)NCCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		1204	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1247	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1375	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		774	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		CHEMBL90	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		DB05381	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		71681476	96431	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	316	8	4	8	1.5	CC(C)CCc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375756	96431	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	316	8	4	8	1.5	CC(C)CCc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		4060730	26151	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm301886t
		CHEMBL129199	26151	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm301886t
		10923241	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL128958	25937	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3cc(O)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		4060730	26151	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL129199	26151	56	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		22660616	82422	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3ccc(O)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047273	82422	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	259	1	2	3	1.3	CN1CCN(C(=O)c2cc3ccc(O)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		71525588	96505	0	None	33	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.1	CNC1CN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376805	96505	0	None	33	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.1	CNC1CN(c2nc(N)nc3cc(C(C)C)cnc23)C1	10.1016/j.bmcl.2013.02.091
		11846300	87041	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm7014217
		CHEMBL213912	87041	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm7014217
		45271470	201829	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	6	3	3	3.1	Cc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL1202329	201829	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	6	3	3	3.1	Cc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		CHEMBL549481	201829	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	6	3	3	3.1	Cc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1	10.1016/j.bmc.2009.04.007
		45270644	202251	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	257	6	4	2	1.7	N=C(NCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmc.2009.04.007
		CHEMBL552694	202251	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	257	6	4	2	1.7	N=C(NCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmc.2009.04.007
		45271464	202282	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	6	3	3	2.9	N=C(NCc1ccc(F)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202328	202282	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	6	3	3	2.9	N=C(NCc1ccc(F)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL553455	202282	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	292	6	3	3	2.9	N=C(NCc1ccc(F)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		10468601	202370	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202324	202370	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL555434	202370	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	274	6	3	3	2.8	N=C(NCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		45268095	202819	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	378	9	3	3	4.8	N=C(NCCC(c1ccccc1)c1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202323	202819	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	378	9	3	3	4.8	N=C(NCCC(c1ccccc1)c1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560313	202819	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	378	9	3	3	4.8	N=C(NCCC(c1ccccc1)c1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1204	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1247	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1375	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		774	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		CHEMBL90	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		DB05381	8713	119	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1274	10836	16	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1039/C2MD20212C
		3063228	10836	16	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1039/C2MD20212C
		CHEMBL1196470	10836	16	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1039/C2MD20212C
		10988959	124886	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL340740	124886	4	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1039/C2MD20212C
		21638785	195437	5	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		CHEMBL503605	195437	5	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		127052294	147080	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806079	147080	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		11751419	144659	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		CHEMBL376268	144659	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		11751419	144659	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2006.08.117
		CHEMBL376268	144659	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	7	1	4	5.6	CN(C)C1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2006.08.117
		57402512	74942	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915022	74942	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	3	2	7	2.2	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(OC)ccc23)C1	10.1016/j.bmcl.2011.08.014
		46228092	206727	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	299	4	1	6	1.4	CN1CCN(c2cc(OCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594973	206727	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	299	4	1	6	1.4	CN1CCN(c2cc(OCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		4024	8796	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		9989505	8796	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL82298	8796	20	None	-301	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	159	2	1	2	1.4	n1ccc(cc1)Cc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		1252	8798	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		9793868	8798	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL417096	8798	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1236	8848	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		1237	8848	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		156615	8848	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		CHEMBL268229	8848	25	None	-204	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		1252	8798	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/jm0504353
		9793868	8798	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/jm0504353
		CHEMBL417096	8798	21	None	-100	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/jm0504353
		81371	19542	11	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	178	3	4	4	0.2	N=C(N)SCCSC(=N)N	10.1021/jm060880d
		CHEMBL1187946	19542	11	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	178	3	4	4	0.2	N=C(N)SCCSC(=N)N	10.1021/jm060880d
		CHEMBL534494	19542	11	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	178	3	4	4	0.2	N=C(N)SCCSC(=N)N	10.1021/jm060880d
		52128564	82408	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	0	3	2.5	CN1CCN(C(=O)c2cc3cc(Cl)ccc3o2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047259	82408	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	278	1	0	3	2.5	CN1CCN(C(=O)c2cc3cc(Cl)ccc3o2)CC1	10.1016/j.ejmech.2012.06.016
		70684084	82444	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	2	2	2.6	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047452	82444	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	2	2	2.6	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		70692528	82450	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047458	82450	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70686224	82464	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	2	2.4	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047472	82464	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	2	2	2	2.4	CN[C@@H]1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		51355156	65684	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	3.1	c1nc(CCCc2cn(C3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688989	65684	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	5	1	4	3.1	c1nc(CCCc2cn(C3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		9990475	63251	0	None	3	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	205	2	2	3	-0.5	Cc1nc(N)[se]c1CCN	10.1016/j.bmcl.2010.10.041
		CHEMBL1632408	63251	0	None	3	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	205	2	2	3	-0.5	Cc1nc(N)[se]c1CCN	10.1016/j.bmcl.2010.10.041
		CHEMBL2448450	63251	0	None	3	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	205	2	2	3	-0.5	Cc1nc(N)[se]c1CCN	10.1016/j.bmcl.2010.10.041
		10583206	116137	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL321920	116137	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		71681640	96438	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nc(Cl)cc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375763	96438	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nc(Cl)cc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		12438303	82407	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	260	1	0	3	2.3	CN1CCN(C(=O)c2cc3ccccc3s2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047258	82407	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	260	1	0	3	2.3	CN1CCN(C(=O)c2cc3ccccc3s2)CC1	10.1016/j.ejmech.2012.06.016
		22660598	82432	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047440	82432	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	273	2	1	3	1.6	COc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		24854636	163096	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	296	1	0	4	2.4	CN1CCN(c2nc3ccccc3nc2C(F)(F)F)CC1	10.1021/jm7014217
		CHEMBL406558	163096	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	296	1	0	4	2.4	CN1CCN(c2nc3ccccc3nc2C(F)(F)F)CC1	10.1021/jm7014217
		10583206	116137	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL321920	116137	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		44395263	73477	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	292	2	2	3	1.7	CN1CCN(NC(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL185546	73477	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	292	2	2	3	1.7	CN1CCN(NC(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		44395336	73564	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	280	4	1	3	1.9	CN(C)CCN(C)C(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL185948	73564	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	280	4	1	3	1.9	CN(C)CCN(C)C(=O)c1nc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		44395290	132295	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	279	4	1	2	2.5	CN(C)CCN(C)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL364629	132295	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	279	4	1	2	2.5	CN(C)CCN(C)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		15984057	146899	0	None	-35481	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	348	5	0	2	5.3	c1cc(-c2ccc(CN3CCCCC3)cc2)ccc1CN1CCCCC1	10.1016/j.bmc.2008.10.029
		CHEMBL380101	146899	0	None	-35481	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	348	5	0	2	5.3	c1cc(-c2ccc(CN3CCCCC3)cc2)ccc1CN1CCCCC1	10.1016/j.bmc.2008.10.029
		71519348	93265	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	3	2	6	1.5	Nc1nc(N2CCNCC2)c2ccn(Cc3ccccc3)c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314766	93265	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	3	2	6	1.5	Nc1nc(N2CCNCC2)c2ccn(Cc3ccccc3)c2n1	10.1016/j.bmcl.2012.10.139
		122193106	130702	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	335	3	2	6	1.9	CN1CCN(c2nc(N)nc(/C=C/c3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628052	130702	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	335	3	2	6	1.9	CN1CCN(c2nc(N)nc(/C=C/c3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		122193095	130692	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628042	130692	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		54585776	68295	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(N)nc(NCCO)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770961	68295	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(N)nc(NCCO)n2)C1	10.1016/j.bmcl.2011.03.017
		24994630	116908	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	2	5	1.6	Nc1nc(C2CCCC2)cc(N2CCC[C@@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236559	116908	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	261	2	2	5	1.6	Nc1nc(C2CCCC2)cc(N2CCC[C@@H](N)C2)n1	10.1021/jm401727m
		25178933	193716	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL490071	193716	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178933	193716	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL490071	193716	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	367	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		122193103	130700	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	341	4	1	8	1.3	CN1CCN(c2nc(N)nc(/C=C/c3cccc([N+](=O)[O-])c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628050	130700	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	341	4	1	8	1.3	CN1CCN(c2nc(N)nc(/C=C/c3cccc([N+](=O)[O-])c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		10446295	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.10.104
		1277	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL185951	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.10.104
		10446295	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.03.017
		1277	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.03.017
		CHEMBL185951	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.03.017
		46890627	13361	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083098	13361	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	2	4	4.0	Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		11340020	91038	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		CHEMBL221210	91038	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		136042265	76685	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938974	76685	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	303	1	2	3	2.0	CN1C[C@H]2CN(C(=N)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		11340020	91038	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL221210	91038	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	454	6	1	4	5.6	CN1CCCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		11189343	148755	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	420	6	1	4	4.9	Cc1cc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)ccc1OCCCN1CCN(C)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL387342	148755	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	420	6	1	4	4.9	Cc1cc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)ccc1OCCCN1CCN(C)CC1	10.1016/j.bmcl.2006.08.117
		57394549	74874	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914748	74874	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		10446295	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
		1277	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
		CHEMBL185951	8913	34	None	269	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1021/jm0502081
		24759624	102907	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	0	5	2.0	COc1nc2cc(Cl)ccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL260444	102907	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	0	5	2.0	COc1nc2cc(Cl)ccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		25147771	181017	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454890	181017	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		44129211	207754	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	383	5	1	7	1.5	CN1CCN(c2nc(NCCS(C)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL601946	207754	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	383	5	1	7	1.5	CN1CCN(c2nc(NCCS(C)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		11821243	25624	8	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	2	1	2	1.9	CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128134	25624	8	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	2	1	2	1.9	CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0341047
		155549319	183103	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	5	2	5	2.0	CCC(=O)N[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4538671	183103	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	5	2	5	2.0	CCC(=O)N[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595399	183103	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	5	2	5	2.0	CCC(=O)N[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		164620704	192862	0	None	-17	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	8	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4871482	192862	0	None	-17	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	8	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1	10.1016/j.ejmech.2021.113190
		127026016	144267	0	None	-13	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753967	144267	0	None	-13	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		71518861	93272	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	5	2.1	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314774	93272	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	5	2.1	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		122193102	130699	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	321	3	1	7	1.2	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628049	130699	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	321	3	1	7	1.2	CN1CCN(c2nc(N)nc(/C=C/c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		63868018	182155	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	208	1	1	6	-0.5	Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4574940	182155	2	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	208	1	1	6	-0.5	Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		71518536	93269	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	3	5	0.3	Cc1cc2c(N3CCNCC3)nc(N)nc2[nH]1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314771	93269	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	3	5	0.3	Cc1cc2c(N3CCNCC3)nc(N)nc2[nH]1	10.1016/j.bmcl.2012.10.139
		57391927	76679	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938969	76679	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	332	2	1	3	2.6	CC(C)N1C[C@H]2CN(C(=O)c3nc4cc(Cl)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		3991311	143639	9	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	296	2	0	5	2.7	CCc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		CHEMBL3741986	143639	9	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	296	2	0	5	2.7	CCc1nc(N2CCN(C)CC2)c2oc3ccccc3c2n1	10.1039/C5MD00022J
		25178556	195864	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL509961	195864	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		44563707	209377	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccc(Cl)cc3nc2OCc2ccccc2)CC1	10.1021/jm800876b
		CHEMBL612059	209377	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccc(Cl)cc3nc2OCc2ccccc2)CC1	10.1021/jm800876b
		24853595	166950	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2cccc(Cl)c2)CC1	10.1021/jm7014217
		CHEMBL410925	166950	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	368	4	0	5	3.6	CN1CCN(c2nc3ccccc3nc2OCc2cccc(Cl)c2)CC1	10.1021/jm7014217
		155535098	183165	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	3	3	5	1.3	CC(C)(C)CNc1nccc(N2CCCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4471442	183165	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	3	3	5	1.3	CC(C)(C)CNc1nccc(N2CCCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595908	183165	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	305	3	3	5	1.3	CC(C)(C)CNc1nccc(N2CCCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		10782821	102997	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	332	4	0	4	3.4	CCN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260850	102997	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	332	4	0	4	3.4	CCN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		164616851	191729	0	None	-446	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4853772	191729	0	None	-446	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		10591811	166132	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	9	1	2	4.7	c1ccc(-c2ccc(CCCOCCCc3c[nH]cn3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4100315	166132	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	320	9	1	2	4.7	c1ccc(-c2ccc(CCCOCCCc3c[nH]cn3)cc2)cc1	10.1016/j.ejmech.2016.09.074
		1267	10576	49	None	-33	27	Human	7.6	pKi	=	7.6	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0341047
		3035905	10576	49	None	-33	27	Human	7.6	pKi	=	7.6	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0341047
		CHEMBL260374	10576	49	None	-33	27	Human	7.6	pKi	=	7.6	Binding	Binding affinity to the human histamine H4 receptorBinding affinity to the human histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm0341047
		24804219	155342	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	378	6	2	5	4.2	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cccc2[nH]1	nan
		CHEMBL3938862	155342	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	378	6	2	5	4.2	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cccc2[nH]1	nan
		11565330	103995	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
		CHEMBL268525	103995	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	275	1	1	2	2.0	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1021/jm0502081
		1267	10576	49	None	-33	27	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2010.02.097
		3035905	10576	49	None	-33	27	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2010.02.097
		CHEMBL260374	10576	49	None	-33	27	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2010.02.097
		71525681	96503	0	None	-3	6	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	96503	0	None	-3	6	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		11846634	84784	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		CHEMBL209758	84784	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		57395496	74948	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915034	74948	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		51354302	65668	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688970	65668	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		25130235	194366	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		25130235	194366	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	194366	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	194366	1	None	-7	11	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		57390225	74657	0	None	-3235	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910384	74657	0	None	-3235	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		55251397	180043	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	2	1	6	0.3	CC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4525008	180043	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	236	2	1	6	0.3	CC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		53233803	68296	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770962	68296	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	3	2	5	1.2	CC(C)Nc1cc(N2CCN(C)CC2)cc(N)n1	10.1016/j.bmcl.2011.03.017
		11293460	91618	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	434	6	1	4	5.1	CN1CCN(CCCOc2ccc(-c3nc4c(ccc5ccccc54)[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL223490	91618	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	434	6	1	4	5.1	CN1CCN(CCCOc2ccc(-c3nc4c(ccc5ccccc54)[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		42624148	116923	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236574	116923	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	3	2	5	0.7	CN[C@@H]1CCN(c2cc(C3CC3)nc(N)n2)C1	10.1021/jm401727m
		11846300	87041	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm800876b
		CHEMBL213912	87041	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm800876b
		11846300	87041	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	87041	3	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		217674	186060	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL473098	186060	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		217674	186060	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL473098	186060	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc(Oc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		156009715	185099	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	601	8	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/c3cc4c5c(c3)CCCN5CCC4)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634631	185099	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	601	8	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/c3cc4c5c(c3)CCCN5CCC4)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4651103	185099	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	601	8	1	3	8.2	Cc1cc(OCCC[n+]2c(C)cc(/C=C/c3cc4c5c(c3)CCCN5CCC4)cc2C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		45257134	206722	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
		CHEMBL594949	206722	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	312	4	2	6	1.7	Cc1cccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)c1	10.1016/j.bmc.2009.08.059
		155539562	179622	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	304	4	1	6	1.7	CN1CCN(c2nc(N)nc(CCC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4514667	179622	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	304	4	1	6	1.7	CN1CCN(c2nc(N)nc(CCC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		10083188	147712	3	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL382276	147712	3	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2011.09.001
		9927983	86627	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	341	1	0	4	4.2	CCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL1795042	86627	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	341	1	0	4	4.2	CCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL212212	86627	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	341	1	0	4	4.2	CCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		49841612	76509	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3cc(-c4ccc(C#N)cc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935568	76509	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	344	2	1	6	2.5	CN1CCN(c2nc(N)nc3cc(-c4ccc(C#N)cc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		54587786	68304	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770970	68304	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	263	4	2	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(N(C)C(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		24825897	74885	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	1	1	6	2.2	CN1CCN(c2nc(N)nc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914759	74885	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	1	1	6	2.2	CN1CCN(c2nc(N)nc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		71519674	96504	0	None	-3	5	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	96504	0	None	-3	5	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		56851610	78402	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	5	2	3	3.8	CC(C)(C)N/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923031	78402	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	5	2	3	3.8	CC(C)(C)N/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963448	78402	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	5	2	3	3.8	CC(C)(C)N/C(=N/C1CCCC1)SCCCc1c[nH]cn1	10.1021/jm201042n
		127049856	147023	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805431	147023	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		10680721	12753	0	None	-23	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	225	6	2	3	1.9	CC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1080089	12753	0	None	-23	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	225	6	2	3	1.9	CC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL158085	12753	0	None	-23	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	225	6	2	3	1.9	CC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		753256	186129	12	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL473662	186129	12	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46228133	206833	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595639	206833	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3cccc(Cl)c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		29136870	75796	7	None	-46	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		CHEMBL1923522	75796	7	None	-46	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		71519176	93258	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	2	5	2.5	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314759	93258	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	2	5	2.5	CN1CCCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		155545717	180248	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	238	3	2	2	2.6	c1ccc2[nH]c(C[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		CHEMBL4529871	180248	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 30 mins by liquid scintillation analysis	ChEMBL	238	3	2	2	2.6	c1ccc2[nH]c(C[C@@H]3C[C@H]3c3c[nH]cn3)nc2c1	10.1016/j.bmcl.2018.10.041
		156015791	185023	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	442	8	1	3	4.6	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCN1CCc2nc[nH]c2C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4646286	185023	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	442	8	1	3	4.6	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCN1CCc2nc[nH]c2C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650609	185023	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	442	8	1	3	4.6	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCN1CCc2nc[nH]c2C1	10.1021/acs.jmedchem.0c00160
		24854638	161974	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL402470	161974	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCc2ccccc2)CC1	10.1021/jm7014217
		24854702	102832	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2cccnc2)CC1	10.1021/jm7014217
		CHEMBL259955	102832	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2cccnc2)CC1	10.1021/jm7014217
		24853592	162936	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	376	7	0	5	3.8	CN1CCN(c2nc3ccccc3nc2OCCCCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL406380	162936	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	376	7	0	5	3.8	CN1CCN(c2nc3ccccc3nc2OCCCCc2ccccc2)CC1	10.1021/jm7014217
		122193104	130666	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3627724	130666	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2015.08.014
		137632569	163051	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	418	7	1	2	4.8	Ic1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4065099	163051	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	418	7	1	2	4.8	Ic1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1	10.1016/j.ejmech.2016.09.074
		53233804	68300	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770966	68300	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	275	3	2	5	1.8	CN1CCN(c2cc(N)nc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2011.03.017
		54583873	68303	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770969	68303	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2011.03.017
		54584824	68311	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770977	68311	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(NC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		54585780	68332	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770998	68332	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	3	2	6	0.6	CC(C)Nc1cc(N2CCN(C)CC2)nc(N)n1	10.1016/j.bmcl.2011.03.017
		58227326	123906	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393542	123906	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	6	2	5	1.5	CCCCNc1nccc(N2CC[C@@H](NC)C2)n1	10.1016/j.bmcl.2014.12.027
		9839217	79294	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		CHEMBL199062	79294	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	297	1	1	3	2.6	Cc1c(Cl)sc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		54583873	68303	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL1770969	68303	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	3	5	1.3	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)c2)C1	10.1016/j.bmcl.2014.10.013
		54585781	68335	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		CHEMBL1771000	68335	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	264	4	2	6	0.9	CC(C)CNc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		71551636	96448	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	263	4	1	5	1.4	CC(C)CCc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375772	96448	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	263	4	1	5	1.4	CC(C)CCc1cc(N2CCN(C)CC2)nc(N)n1	10.1021/jm301886t
		25129527	194193	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm301886t
		CHEMBL493720	194193	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1021/jm301886t
		46881855	14518	0	None	15	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089040	14518	0	None	15	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		10967174	26214	3	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129540	26214	3	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity of compound towards rat histamine H4 receptorBinding affinity of compound towards rat histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		46890166	14088	0	None	4786	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086105	14088	0	None	4786	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	419	6	2	4	4.5	Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		1278	8931	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	8931	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	8931	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	8931	84	None	-3	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		71603136	96490	0	None	46	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	3	2	5	2.3	CNC1CN(c2nc(N)nc3cc(C4CCCC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376790	96490	0	None	46	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	297	3	2	5	2.3	CNC1CN(c2nc(N)nc3cc(C4CCCC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		25109291	198165	10	None	-79	8	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	198165	10	None	-79	8	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		127050309	147627	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	283	2	2	6	1.8	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1039/C6MD00108D
		CHEMBL3819470	147627	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	283	2	2	6	1.8	CN[C@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1039/C6MD00108D
		53476465	74829	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	2	2	6	2.0	NCC1CN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914547	74829	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	303	2	2	6	2.0	NCC1CN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		24737947	74902	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	283	2	2	6	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914776	74902	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	283	2	2	6	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccccc23)C1	10.1016/j.bmcl.2011.08.014
		25071004	199497	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL521996	199497	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		25071004	199497	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL521996	199497	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		11957573	8791	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		1250	8791	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		3692	8791	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL19439	8791	34	None	-40	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm7014777
		24826358	74871	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	1	2	6	2.4	Nc1nc(N2CC3CCNC3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914745	74871	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	329	1	2	6	2.4	Nc1nc(N2CC3CCNC3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25101945	199885	0	None	3	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL522673	199885	0	None	3	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	2	2	5	1.6	CNC1CN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		58227401	183230	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4443126	183230	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596409	183230	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	263	4	2	5	1.7	CN[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		25068753	195217	19	None	1	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL502347	195217	19	None	1	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		1278	8931	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	8931	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	8931	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	8931	84	None	-4	8	Mouse	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from mouse H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1267	10576	49	None	-33	27	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
		3035905	10576	49	None	-33	27	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
		CHEMBL260374	10576	49	None	-33	27	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2009.08.059
		21638785	195437	5	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		CHEMBL503605	195437	5	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	263	1	2	2	1.9	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCNCC1	10.1021/jm800670r
		24994636	116914	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
		CHEMBL3236565	116914	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	3	3	6	0.5	CN[C@H]1CN(c2cc(C3CCCC3)nc(N)n2)C[C@@H]1O	10.1021/jm401727m
		24826441	74880	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1cccc2oc3c(N4CCN(C)CC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		CHEMBL1914754	74880	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	1	7	1.7	COc1cccc2oc3c(N4CCN(C)CC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		10244243	148091	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		CHEMBL383384	148091	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1cccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		73353369	96488	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	6	0.4	CN1CCN(c2nc(N)nc3cccnc23)CC1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376788	96488	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	6	0.4	CN1CCN(c2nc(N)nc3cccnc23)CC1	10.1016/j.bmcl.2013.02.091
		11846636	84727	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		CHEMBL209628	84727	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(F)cccc32)CC1	10.1021/jm051008s
		155513612	183099	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4439142	183099	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4515149	183099	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		CHEMBL4595327	183099	0	None	-1	4	Mouse	7.5	pKi	=	7.5	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.0c00160
		206876	25717	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		CHEMBL128637	25717	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		206876	25717	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL128637	25717	7	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		11249610	164746	0	None	-6309	2	Human	4.5	pKi	=	4.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	354	9	2	5	3.6	Nc1ccc(NCCc2ccc(OCCCN3CCCCC3)cc2)nc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4084820	164746	0	None	-6309	2	Human	4.5	pKi	=	4.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	354	9	2	5	3.6	Nc1ccc(NCCc2ccc(OCCCN3CCCCC3)cc2)nc1	10.1016/j.ejmech.2016.09.074
		137634777	162755	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	453	8	3	6	1.0	CCOC(=O)CN1Cc2ccccc2C[C@@H](NC(=O)C(Cc2ccccc2)C(=O)NO)C1=O	10.1016/j.ejmech.2016.09.074
		CHEMBL4061504	162755	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	453	8	3	6	1.0	CCOC(=O)CN1Cc2ccccc2C[C@@H](NC(=O)C(Cc2ccccc2)C(=O)NO)C1=O	10.1016/j.ejmech.2016.09.074
		164611474	192231	0	None	-478	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	6	4	5	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1	10.1016/j.ejmech.2021.113190
		CHEMBL4861704	192231	0	None	-478	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	6	4	5	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1	10.1016/j.ejmech.2021.113190
		164619427	192848	0	None	-7	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	5	4	4	3.1	N/C(=N\C(=O)NCCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4871221	192848	0	None	-7	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	5	4	4	3.1	N/C(=N\C(=O)NCCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		164627774	193344	0	None	-58	6	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	344	3	4	4	1.4	N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		CHEMBL4878215	193344	0	None	-58	6	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	344	3	4	4	1.4	N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		24994634	8923	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	8923	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	8923	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		24994634	8923	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from guinea pig recombinant histamine H4 receptorDisplacement of [3H]histamine from guinea pig recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	8923	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from guinea pig recombinant histamine H4 receptorDisplacement of [3H]histamine from guinea pig recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	8923	31	None	-60	7	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from guinea pig recombinant histamine H4 receptorDisplacement of [3H]histamine from guinea pig recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		155552341	183163	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	4	3	5	1.7	CC(C)(C)CNc1nccc(NC2CCNC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543928	183163	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	4	3	5	1.7	CC(C)(C)CNc1nccc(NC2CCNC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595906	183163	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	4	3	5	1.7	CC(C)(C)CNc1nccc(NC2CCNC2)n1	10.1021/acs.jmedchem.9b01342
		44129283	207806	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3ccc(Cl)c(Cl)c3n2)CC1	10.1021/jm901379s
		CHEMBL602330	207806	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3ccc(Cl)c(Cl)c3n2)CC1	10.1021/jm901379s
		11846299	145998	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
		CHEMBL378788	145998	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3cc(Cl)ccc32)CC1	10.1021/jm051008s
		10934567	26030	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		CHEMBL129026	26030	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		10934567	26030	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		CHEMBL129026	26030	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		25128833	195181	38	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL501882	195181	38	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	193	1	1	5	-0.2	CN1CCN(c2ccnc(N)n2)CC1	10.1016/j.bmcl.2011.10.104
		24826354	74915	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914790	74915	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2sc2ccc(F)cc23)C1	10.1016/j.bmcl.2011.08.014
		10934567	26030	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL129026	26030	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	271	1	1	2	2.2	Cc1cc(C)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		16006947	145835	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL378619	145835	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	247	6	2	2	3.1	c1nc([C@@H]2C[C@H]2CCNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		136030655	63256	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632413	63256	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		9923162	25712	6	None	199	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL128613	25712	6	None	199	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		170389	213760	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634086	213760	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL91353	213760	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		1274	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
		3063228	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
		CHEMBL1196470	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1016/j.bmcl.2010.10.041
		170389	213760	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL4634086	213760	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL91353	213760	35	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.3	NCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		71681808	96423	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	3	8	3.1	CC(C)CNc1nccc(NCCN(C)c2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375748	96423	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	3	8	3.1	CC(C)CNc1nccc(NCCN(C)c2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		1274	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm201042n
		3063228	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm201042n
		CHEMBL1196470	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm201042n
		56851608	78405	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	334	6	2	3	4.3	c1nc(CCCS/C(=N\C2CCCC2)NC2CCCCC2)c[nH]1	10.1021/jm201042n
		CHEMBL1923030	78405	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	334	6	2	3	4.3	c1nc(CCCS/C(=N\C2CCCC2)NC2CCCCC2)c[nH]1	10.1021/jm201042n
		CHEMBL1963461	78405	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	334	6	2	3	4.3	c1nc(CCCS/C(=N\C2CCCC2)NC2CCCCC2)c[nH]1	10.1021/jm201042n
		1274	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
		3063228	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
		CHEMBL1196470	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	10.1021/jm060880d
		1278	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		1279	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		4908365	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		CHEMBL129198	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		66572105	82412	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047263	82412	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	1	1	2	1.7	CN1CCN(C(=O)c2cc3c(F)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572106	82413	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3c(Cl)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047264	82413	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(C(=O)c2cc3c(Cl)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573463	82446	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	2	3.1	Cc1cc(Cl)cc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047454	82446	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	317	2	1	2	3.1	Cc1cc(Cl)cc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		70696622	82461	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047469	82461	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10988959	124886	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL340740	124886	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10087533	202789	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	322	7	3	3	3.5	N=C(NCCc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202322	202789	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	322	7	3	3	3.5	N=C(NCCc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL560068	202789	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	322	7	3	3	3.5	N=C(NCCc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		46929648	23531	0	None	-6	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		CHEMBL1243395	23531	0	None	-6	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		137650793	164221	0	None	-1096	2	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	484	7	1	4	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc(Br)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4078910	164221	0	None	-1096	2	Human	5.5	pKi	=	5.5	Binding	Antagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	484	7	1	4	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc(Br)c1	10.1016/j.ejmech.2016.09.074
		46912442	17676	0	None	-575	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	271	4	1	3	2.9	COc1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		CHEMBL1172775	17676	0	None	-575	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting	ChEMBL	271	4	1	3	2.9	COc1ccc(N2CCC(Cc3c[nH]cn3)CC2)cc1	10.1016/j.bmc.2010.04.052
		57392460	76641	0	None	14	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938843	76641	0	None	14	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cccnc3[nH]2)CC1	10.1016/j.bmcl.2011.11.098
		136192886	63254	0	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632411	63254	0	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1248	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		3077	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		90045	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		CHEMBL12344	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1016/j.bmcl.2010.10.041
		1239	8814	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1240	8814	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		912	8814	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL268490	8814	24	None	-154	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	3	2	2	0.2	CNCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		71681976	96426	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	5	4	5	2.0	Nc1nccc(NCCNC(=O)c2cc3cc(Cl)ccc3[nH]2)n1	10.1021/jm301886t
		CHEMBL2375751	96426	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	330	5	4	5	2.0	Nc1nccc(NCCNC(=O)c2cc3cc(Cl)ccc3[nH]2)n1	10.1021/jm301886t
		10023327	175795	0	None	-144	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor N4.57Y mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11622672	81794	2	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	1	2	2.6	c1nc(CCCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL203389	81794	2	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	6	1	2	2.6	c1nc(CCCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		11679919	82316	0	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL204413	82316	0	None	-39	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCNCCCCCc1c[nH]cn1	10.1021/jm0504353
		11701199	82347	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	1	2	2.1	CCN(CC)CCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL204615	82347	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	1	2	2.1	CCN(CC)CCCCc1c[nH]cn1	10.1021/jm0504353
		1248	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		3077	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		90045	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		CHEMBL12344	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm060880d
		4060730	26151	56	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL129199	26151	56	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		10377814	82417	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3c(N)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047268	82417	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3c(N)cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1248	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		3077	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		90045	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		CHEMBL12344	8206	28	None	-15	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hrDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1039/C2MD20212C
		4563101	73532	11	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	265	4	2	2	2.1	CN(C)CCNC(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL185842	73532	11	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	265	4	2	2	2.1	CN(C)CCNC(=O)c1cc2cc(Cl)ccc2[nH]1	10.1016/j.bmcl.2004.08.035
		71681977	96427	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	344	5	3	5	2.4	CN(CCNc1ccnc(N)n1)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1021/jm301886t
		CHEMBL2375752	96427	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	344	5	3	5	2.4	CN(CCNc1ccnc(N)n1)C(=O)c1cc2cc(Cl)ccc2[nH]1	10.1021/jm301886t
		71681479	96435	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	393	9	5	9	2.7	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375760	96435	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	393	9	5	9	2.7	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		3063453	19544	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	189	5	5	3	-0.1	N=C(N)NCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL1187950	19544	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	189	5	5	3	-0.1	N=C(N)NCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL534498	19544	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	189	5	5	3	-0.1	N=C(N)NCCCCSC(=N)N	10.1021/jm060880d
		112936341	144252	1	None	-12	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753849	144252	1	None	-12	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		164628701	193246	0	None	-186	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	5	4	4	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4876743	193246	0	None	-186	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	5	4	4	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1	10.1016/j.ejmech.2021.113190
		57402928	76640	0	None	9	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	0	4	1.4	CN1CCN(C(=O)c2cn3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938842	76640	0	None	9	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	0	4	1.4	CN1CCN(C(=O)c2cn3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.11.098
		121238071	174019	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	271	2	1	7	0.3	CN1CCN(c2nc(N)nc(-c3ccncc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4292486	174019	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	271	2	1	7	0.3	CN1CCN(c2nc(N)nc(-c3ccncc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		11120826	25690	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128505	25690	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		11120826	25690	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128505	25690	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0341047
		49841720	76498	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3c(-c4ccccc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935557	76498	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	319	2	1	5	2.6	CN1CCN(c2nc(N)nc3c(-c4ccccc4)cccc23)CC1	10.1016/j.bmcl.2011.10.104
		44275465	105997	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL281590	105997	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		46890545	14157	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086460	14157	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	1	4	4.0	Cc1cc(OCCCN2CCN(C)CC2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		11120826	25690	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128505	25690	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(Br)cccc3[nH]2)CC1	10.1021/jm0502081
		57399829	75105	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	235	7	2	5	1.3	CN(C)CCNc1cc(NCC2CC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916505	75105	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	235	7	2	5	1.3	CN(C)CCNc1cc(NCC2CC2)ncn1	10.1016/j.bmcl.2011.07.114
		44126357	122693	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(N)nc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354813	122693	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	3	2	5	1.0	CN[C@@H]1CCN(c2cc(N)nc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		57393772	74952	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Br)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915041	74952	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Br)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		24854637	103094	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc3ccccc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261363	103094	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	320	3	0	5	3.2	CN1CCN(c2nc3ccccc3nc2Oc2ccccc2)CC1	10.1021/jm7014217
		11738520	146044	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1O2	10.1021/jm051008s
		CHEMBL1794919	146044	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1O2	10.1021/jm051008s
		CHEMBL379044	146044	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1O2	10.1021/jm051008s
		60150162	180645	0	None	-524	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	479	16	2	4	4.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4539444	180645	0	None	-524	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	479	16	2	4	4.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		164624107	192501	0	None	-70	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4865765	192501	0	None	-70	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
		164608941	191162	0	None	-75	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4845733	191162	0	None	-75	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		57392890	75091	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	370	7	1	5	2.5	COc1cccc(C(O)(COc2ccccc2C)CN2CCN(C)CC2)c1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916492	75091	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	370	7	1	5	2.5	COc1cccc(C(O)(COc2ccccc2C)CN2CCN(C)CC2)c1	10.1016/j.bmcl.2011.07.114
		21029584	195645	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncnc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL506969	195645	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncnc3ccccc23)CC1	10.1016/j.bmcl.2011.10.104
		1267	10576	49	None	-33	27	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014777
		3035905	10576	49	None	-33	27	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014777
		CHEMBL260374	10576	49	None	-33	27	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014777
		90655029	116912	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.4	Nc1nc(C2CCCC2)cc(N2C[C@@H]3CNC[C@@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236563	116912	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	273	2	2	5	1.4	Nc1nc(C2CCCC2)cc(N2C[C@@H]3CNC[C@@H]3C2)n1	10.1021/jm401727m
		71518862	93273	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	342	2	2	5	2.6	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314775	93273	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	342	2	2	5	2.6	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		44547567	123897	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393533	123897	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		24826163	74941	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915020	74941	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		57393773	74954	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	1	7	1.8	CN1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915044	74954	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	1	7	1.8	CN1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		11572877	73854	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL187285	73854	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)c2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		44129210	206264	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	7	2	7	1.4	CNS(=O)(=O)CCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591711	206264	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	412	7	2	7	1.4	CNS(=O)(=O)CCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		156015638	185051	0	None	-58	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4642520	185051	0	None	-58	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4650832	185051	0	None	-58	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	415	10	1	2	5.5	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		25179127	195858	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL509852	195858	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25179127	195858	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL509852	195858	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1ccsc1CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		71518863	93274	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	338	3	2	6	2.0	COc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314776	93274	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	338	3	2	6	2.0	COc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		8070960	162471	10	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	258	2	0	5	1.4	COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL405044	162471	10	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	258	2	0	5	1.4	COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		25130576	194405	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		25130576	194405	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		CHEMBL494890	194405	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		CHEMBL494890	194405	1	None	-8	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		86277887	130589	26	None	-	1	Human	5.5	pKi	=	5.5	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL	802	18	0	11	7.4	COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@H](c2cc(OC)c(OC)c(OC)c2)C2CCCCC2)c2cccc(OCCN3CCOCC3)c2)cc1OC	10.6019/CHEMBL5058648
		CHEMBL3623630	130589	26	None	-	1	Human	5.5	pKi	=	5.5	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL	802	18	0	11	7.4	COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@H](c2cc(OC)c(OC)c(OC)c2)C2CCCCC2)c2cccc(OCCN3CCOCC3)c2)cc1OC	10.6019/CHEMBL5058648
		168294445	199789	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208113	199789	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222768	199789	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		25130235	194366	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		25130235	194366	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	194366	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	194366	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		46228076	208879	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	354	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(C(C)(C)C)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL608864	208879	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	354	4	2	6	2.7	CN1CCN(c2cc(NCc3ccc(C(C)(C)C)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46228158	208937	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL609289	208937	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	4	2	7	1.3	CN1CCN(c2cc(NCc3ccc(C#N)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		57402514	74950	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Br)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915039	74950	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	375	1	2	6	2.7	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Br)cc3c2n1	10.1016/j.bmcl.2011.08.014
		164619039	192927	0	None	-17	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	4	4	4	3.0	N/C(=N\C(=O)NCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4872277	192927	0	None	-17	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	4	4	4	3.0	N/C(=N\C(=O)NCc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		57392889	75090	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	379	4	1	5	2.2	CN1CCN(c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916491	75090	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	379	4	1	5	2.2	CN1CCN(c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		25130235	194366	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	194366	1	None	1	11	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		57393774	74955	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.4	Nc1nc(N2CCNCC2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915045	74955	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	1	2	7	1.4	Nc1nc(N2CCNCC2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		10083188	147712	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL382276	147712	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2nc3ccccc3[nH]2)CC1	10.1021/jm0502081
		1278	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		1279	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		4908365	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		CHEMBL129198	8931	84	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine 4 receptor (unknown origin)Binding affinity to histamine 4 receptor (unknown origin)	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		71603137	96491	0	None	23	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	1	2	5	1.9	CC(C)(C)c1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376791	96491	0	None	23	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	1	2	5	1.9	CC(C)(C)c1ccc2c(N3CCNCC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25179125	195803	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL509142	195803	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25179125	195803	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL509142	195803	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3ccsc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		127051047	147089	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806162	147089	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		7015108	206685	8	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	3	0	7	1.7	CN1CCN(c2ncnc3c2nnn3Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594729	206685	8	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	3	0	7	1.7	CN1CCN(c2ncnc3c2nnn3Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2009.08.059
		46228070	206504	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	271	4	0	5	1.1	CN1CCN(Cc2cn(Cc3ccccc3)nn2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593448	206504	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	271	4	0	5	1.1	CN1CCN(Cc2cn(Cc3ccccc3)nn2)CC1	10.1016/j.bmc.2009.08.059
		122193100	130697	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	314	3	1	6	1.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc(F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628047	130697	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	314	3	1	6	1.5	CN1CCN(c2nc(N)nc(/C=C/c3cccc(F)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		155513612	183099	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		127050018	147546	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	221	2	2	5	0.5	CN[C@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1039/C6MD00108D
		CHEMBL3818402	147546	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibition of histamine H4 receptor (unknown origin)Inhibition of histamine H4 receptor (unknown origin)	ChEMBL	221	2	2	5	0.5	CN[C@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1039/C6MD00108D
		24994950	116930	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.5	CN[C@@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1021/jm401727m
		CHEMBL3236580	116930	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.5	CN[C@@H]1CCN(c2nc(N)nc(C)c2C)C1	10.1021/jm401727m
		54583875	68329	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770995	68329	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		90655028	116906	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@H](N)C2)n1	10.1021/jm401727m
		CHEMBL3236557	116906	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	1.3	Nc1nc(C2CCCC2)cc(N2CC[C@H](N)C2)n1	10.1021/jm401727m
		59777262	116921	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236572	116921	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	283	4	2	5	1.4	CN[C@@H]1CCN(c2cc(Cc3ccccc3)nc(N)n2)C1	10.1021/jm401727m
		155512725	183020	0	None	154	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4437371	183020	0	None	154	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4594753	183020	0	None	154	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	237	6	3	5	1.7	CC(C)(C)CNc1nccc(NCCCN)n1	10.1021/acs.jmedchem.9b01342
		46929553	23525	0	None	-5	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2cccnc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243366	23525	0	None	-5	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2cccnc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		71519011	93239	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	376	2	2	5	3.3	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)c(Cl)c4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314496	93239	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	376	2	2	5	3.3	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Cl)c(Cl)c4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		24826598	74944	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	2	7	1.9	COc1ccc2oc3c(N4CCC[C@H](N)C4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915027	74944	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	313	2	2	7	1.9	COc1ccc2oc3c(N4CCC[C@H](N)C4)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		25178939	193629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm800876b
		CHEMBL489464	193629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm800876b
		24853529	102898	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	336	3	0	5	3.5	CN1CCN(c2nc3ccccc3nc2Sc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260388	102898	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	336	3	0	5	3.5	CN1CCN(c2nc3ccccc3nc2Sc2ccccc2)CC1	10.1021/jm7014217
		25178939	193629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm901379s
		CHEMBL489464	193629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	397	5	1	6	3.7	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)cc1	10.1021/jm901379s
		164611757	191682	0	None	-50	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4853107	191682	0	None	-50	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		112936357	144137	1	None	-18	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752978	144137	1	None	-18	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		71519346	93263	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	2	6	-0.0	Cn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		CHEMBL2314764	93263	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	232	1	2	6	-0.0	Cn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		58227144	123919	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2cnnc(NC3CC4CCC3C4)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393555	123919	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2cnnc(NC3CC4CCC3C4)c2)CC1	10.1016/j.bmcl.2014.12.027
		57399018	74957	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	332	1	1	7	2.1	CN1CCCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915047	74957	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	332	1	1	7	2.1	CN1CCCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		16082831	87121	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL214311	87121	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		25178554	180206	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm800876b
		CHEMBL452870	180206	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm800876b
		25178554	180206	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm901379s
		CHEMBL452870	180206	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	8	2.3	Cc1noc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)n1	10.1021/jm901379s
		164610892	191977	0	None	-52	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4857560	191977	0	None	-52	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
		71518864	93275	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	Cc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314777	93275	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	322	2	2	5	2.3	Cc1ccc(-c2cc3c(N4CCN(C)CC4)nc(N)nc3[nH]2)cc1	10.1016/j.bmcl.2012.10.139
		122194626	130800	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629829	130800	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1ccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2015.08.014
		57399019	74961	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	2	2	7	1.4	NCC1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915051	74961	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	304	2	2	7	1.4	NCC1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		90645146	118954	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	288	2	1	6	1.0	CN1CCN(c2nc(N)nc(-c3ccc(F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290577	118954	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	288	2	1	6	1.0	CN1CCN(c2nc(N)nc(-c3ccc(F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		54584374	69898	0	None	-6	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774590	69898	0	None	-6	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789360	69898	0	None	-6	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		122193105	130701	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628051	130701	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	346	3	1	6	2.5	CN1CCN(c2nc(N)nc(/C=C/c3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		921599	26227	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0341047
		CHEMBL129660	26227	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0341047
		921599	26227	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0502081
		CHEMBL129660	26227	51	None	234	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	10.1021/jm0502081
		4060730	26151	56	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.02.097
		CHEMBL129199	26151	56	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine human recombinant histamine H4 receptorDisplacement of [3H]histamine human recombinant histamine H4 receptor	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.02.097
		25178553	180205	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm800876b
		CHEMBL452869	180205	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm800876b
		25178553	180205	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm901379s
		CHEMBL452869	180205	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	4	1	6	4.0	Cc1csc(CNc2nc(N3CCN(C)CC3)nc3ccc(Cl)cc23)c1	10.1021/jm901379s
		11846465	148710	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
		CHEMBL387054	148710	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	345	0	0	4	3.9	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3cc(F)ccc32)CC1	10.1021/jm051008s
		56851606	78375	0	None	-11	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	432	8	2	3	5.7	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1923029	78375	0	None	-11	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	432	8	2	3	5.7	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		CHEMBL1963244	78375	0	None	-11	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	432	8	2	3	5.7	Clc1ccc(C/N=C(/NCc2ccccc2)SCCCc2c[nH]cn2)cc1Cl	10.1021/jm201042n
		51354877	65683	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCc2cn(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688988	65683	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	7	1	4	3.1	c1nc(CCCc2cn(CCC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		137658819	166089	0	None	-7585	2	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	467	9	1	5	3.9	COc1cc2c(cc1OC)C(C)=C(C(=O)NCCCCN1CCN(c3ccccc3F)CC1)C2	10.1016/j.ejmech.2016.09.074
		CHEMBL4099779	166089	0	None	-7585	2	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	467	9	1	5	3.9	COc1cc2c(cc1OC)C(C)=C(C(=O)NCCCCN1CCN(c3ccccc3F)CC1)C2	10.1016/j.ejmech.2016.09.074
		54584374	69898	0	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774590	69898	0	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789360	69898	0	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	223	7	2	3	1.6	C=CCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		58227207	123915	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393551	123915	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		51354872	66973	0	None	-323	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	291	6	0	5	2.1	c1c(CN2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		CHEMBL1688983	66973	0	None	-323	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	291	6	0	5	2.1	c1c(CN2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		CHEMBL1739923	66973	0	None	-323	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	291	6	0	5	2.1	c1c(CN2CCCCC2)nnn1CCCN1CCCCC1	10.1021/jm1013488
		68081433	116900	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	248	1	1	3	0.7	CN1CCN(C(=O)c2nc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		CHEMBL3236551	116900	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	248	1	1	3	0.7	CN1CCN(C(=O)c2nc3c([nH]2)CCCC3)CC1	10.1021/jm401727m
		57399747	74912	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	2	2	6	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914787	74912	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	319	2	2	6	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(F)c(F)c23)C1	10.1016/j.bmcl.2011.08.014
		25129169	193960	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		CHEMBL492231	193960	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		25129169	193960	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL492231	193960	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		3032915	22267	24	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL12160	22267	24	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		71681806	96420	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	331	8	4	9	1.0	CC(C)CNc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375667	96420	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	331	8	4	9	1.0	CC(C)CNc1cc(N(C)CCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		71681639	96437	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	321	6	3	7	2.3	Cc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375762	96437	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	321	6	3	7	2.3	Cc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		11492393	10832	6	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	7	2	2	3.0	C(CCc1cnc[nH]1)CCNC1CCCCC1	10.1021/jm0504353
		1263	10832	6	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	7	2	2	3.0	C(CCc1cnc[nH]1)CCNC1CCCCC1	10.1021/jm0504353
		CHEMBL206346	10832	6	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	7	2	2	3.0	C(CCc1cnc[nH]1)CCNC1CCCCC1	10.1021/jm0504353
		11557610	81222	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	7	2	2	2.7	c1nc(CCCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL202744	81222	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	7	2	2	2.7	c1nc(CCCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		11615406	146270	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	2	2	2.3	c1nc(CCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL379447	146270	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	2	2	2.3	c1nc(CCCCNC2CCCC2)c[nH]1	10.1021/jm0504353
		66572116	82435	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	2	2	1.5	Cc1cccc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047443	82435	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	2	2	1.5	Cc1cccc2cc(C(=O)N3CCNCC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		70681961	82447	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.6	CN1CCCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047455	82447	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.6	CN1CCCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70696621	82454	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	2	2.2	O=C(c1cc2cccc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047462	82454	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	287	2	1	2	2.2	O=C(c1cc2cccc(F)c2[nH]1)N1CC(N2CCCC2)C1	10.1016/j.ejmech.2012.06.016
		70692531	82467	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.0	Cc1ccc(F)c2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047475	82467	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.0	Cc1ccc(F)c2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		24759623	103124	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm800876b
		CHEMBL261551	103124	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm800876b
		25129169	193960	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		CHEMBL492231	193960	0	None	-8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		24759623	103124	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261551	103124	20	None	18	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		10429016	202939	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	366	7	3	3	3.6	N=C(NCCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL561250	202939	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	366	7	3	3	3.6	N=C(NCCc1ccc(Br)cc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1223	7740	41	None	-60	11	Human	7.4	pKi	=	7.4	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.4	pKi	=	7.4	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.4	pKi	=	7.4	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		71519012	93240	0	None	218	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.8	Nc1nc(N2CCNCC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314497	93240	0	None	218	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.8	Nc1nc(N2CCNCC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		10934158	115354	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		CHEMBL320331	115354	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1016/j.bmcl.2010.10.041
		71681478	96434	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	4	8	3.2	CC(C)CCc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375759	96434	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	392	9	4	8	3.2	CC(C)CCc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)nc(N)n1	10.1021/jm301886t
		11629829	82797	0	None	-19	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	5	1	2	2.2	c1nc(CCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL205583	82797	0	None	-19	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	5	1	2	2.2	c1nc(CCCCN2CCCCC2)c[nH]1	10.1021/jm0504353
		25831	19780	28	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	144	3	6	2	-2.0	N=C(N)NCCNC(=N)N	10.1021/jm060880d
		CHEMBL1189742	19780	28	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	144	3	6	2	-2.0	N=C(N)NCCNC(=N)N	10.1021/jm060880d
		CHEMBL539343	19780	28	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	144	3	6	2	-2.0	N=C(N)NCCNC(=N)N	10.1021/jm060880d
		1278	8931	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		1279	8931	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		4908365	8931	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		CHEMBL129198	8931	84	None	-3	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1039/C2MD20212C
		66573456	82437	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	2	2	2	1.5	CNC1CN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047445	82437	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	2	2	2	1.5	CNC1CN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		43398194	82448	25	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	CN1CCCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047456	82448	25	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	CN1CCCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70694582	82452	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047460	82452	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	275	1	1	2	2.1	CN1CCCN(C(=O)c2cc3cccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		70686223	82457	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	2	2	2	1.4	CNC1CN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047465	82457	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	247	2	2	2	1.4	CNC1CN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		70692530	82466	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047474	82466	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	322	2	1	4	2.1	CN1CCN(C(=O)c2cc3cc(Cl)cc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1238	8863	13	None	-19	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		6603865	8863	13	None	-19	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		CHEMBL11919	8863	13	None	-19	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	10.1016/j.bmcl.2010.10.041
		44417445	19574	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	217	7	5	3	0.7	N=C(N)NCCCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL1188154	19574	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	217	7	5	3	0.7	N=C(N)NCCCCCCSC(=N)N	10.1021/jm060880d
		CHEMBL535387	19574	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	217	7	5	3	0.7	N=C(N)NCCCCCCSC(=N)N	10.1021/jm060880d
		66572102	82409	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ncccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047260	82409	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3ncccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		24854634	162935	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	400	4	0	4	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2CCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL406379	162935	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	400	4	0	4	4.5	CN1CCN(c2nc3cc(Cl)c(Cl)cc3nc2CCc2ccccc2)CC1	10.1021/jm7014217
		24853528	173861	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	329	6	0	6	1.7	CN(C)CCCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL428964	173861	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	329	6	0	6	1.7	CN(C)CCCOc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		137659490	165975	0	None	11	2	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	420	7	1	2	6.1	Brc1ccc(C(OCCCc2c[nH]cn2)c2ccc3ccccc3c2)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4098585	165975	0	None	11	2	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	420	7	1	2	6.1	Brc1ccc(C(OCCCc2c[nH]cn2)c2ccc3ccccc3c2)cc1	10.1016/j.ejmech.2016.09.074
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1007/s00044-004-0106-7
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0341047
		24803709	152708	1	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cc(F)cc2[nH]1	nan
		CHEMBL3917992	152708	1	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting methodDisplacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in human SK-N-MC cells or African green monkey COS7 cell membranes after 45 mins by scintillation counting method	ChEMBL	396	6	2	5	4.3	Cc1nc(NCCCC2CCN(C)CC2)ncc1-c1nc2c(C)cc(F)cc2[nH]1	nan
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		49841846	76513	0	None	18	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935572	76513	0	None	18	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		44129130	206335	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL592379	206335	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.10.104
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.03.017
		24745337	68313	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770979	68313	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	5	3	6	0.9	CN[C@@H]1CCN(c2cc(NCC(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		58227340	123896	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393532	123896	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	4	2	4	2.2	CN[C@@H]1CCN(c2ccnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm0502081
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm800876b
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	8931	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	8931	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	8931	84	None	3	8	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from rat H4R expressed in HEK293T cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		44129133	206164	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	398	6	2	7	1.0	CNS(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591011	206164	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	398	6	2	7	1.0	CNS(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		1223	7740	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2011.03.046
		2790	7740	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2011.03.046
		CHEMBL14690	7740	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmc.2011.03.046
		1223	7740	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmcl.2009.10.005
		2790	7740	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmcl.2009.10.005
		CHEMBL14690	7740	41	None	-60	11	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1016/j.bmcl.2009.10.005
		25129169	193960	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL492231	193960	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		44129134	206287	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591969	206287	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	384	5	2	7	0.7	CN1CCN(c2nc(NCCS(N)(=O)=O)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25129169	193960	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		CHEMBL492231	193960	0	None	8	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	323	2	2	5	2.3	Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1	10.1021/jm800670r
		1278	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		1279	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		4908365	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.5b00516
		24745506	74994	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915537	74994	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	278	5	3	6	1.3	CNC1CN(c2cc(NCCC(C)(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.07.125
		136042266	76686	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		CHEMBL1938975	76686	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	301	1	2	3	1.8	Cc1c(F)ccc2[nH]c(C(=N)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		136042268	76688	0	None	186	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938977	76688	0	None	186	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	287	1	2	3	1.5	CN1C[C@H]2CN(C(=N)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		25068753	195217	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL502347	195217	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		1278	8931	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1279	8931	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		4908365	8931	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		CHEMBL129198	8931	84	None	3	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		25068753	195217	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL502347	195217	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		2063135	15150	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1093180	15150	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1016/j.bmcl.2011.08.014
		24826437	74872	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@H]3CCCN[C@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914746	74872	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	343	1	2	6	2.8	Nc1nc(N2C[C@H]3CCCN[C@H]3C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25128823	199496	0	None	2	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		CHEMBL521995	199496	0	None	2	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	267	1	2	5	1.0	Nc1nc2c(c(N3CCNCC3)n1)Cc1ccccc1-2	10.1021/jm800670r
		1204	8713	119	None	-3	25	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	8713	119	None	-3	25	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	8713	119	None	-3	25	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	8713	119	None	-3	25	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	8713	119	None	-3	25	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	8713	119	None	-3	25	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1278	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		1279	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		4908365	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		CHEMBL129198	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assayDisplacement of [3H]histamine from human histamine 4 receptor expressed in HEK293T cell membranes incubated for 1 hr by radioligand binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2015.12.035
		44129130	206335	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592379	206335	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	460	7	2	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		54581941	68331	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	288	2	2	6	0.8	Nc1nc(N2CCCC2)cc(N2CC3CCCNC3C2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770997	68331	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	288	2	2	6	0.8	Nc1nc(N2CCCC2)cc(N2CC3CCCNC3C2)n1	10.1016/j.bmcl.2011.03.017
		24826680	74903	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914777	74903	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	2	2	6	2.4	CN[C@@H]1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)C1	10.1016/j.bmcl.2011.08.014
		11601630	139595	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL370135	139595	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	283	1	1	3	2.3	CN1CCN(C(=O)c2cc3sc(Cl)cc3[nH]2)CC1	10.1021/jm0502081
		137640214	163746	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	394	6	1	2	5.5	O=C(NCCCCN1Cc2cccc3cccc(c23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4072893	163746	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	394	6	1	2	5.5	O=C(NCCCCN1Cc2cccc3cccc(c23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2016.09.074
		71519013	93241	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	3	2	5	2.5	CCN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314498	93241	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	3	2	5	2.5	CCN1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		168284289	199685	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5194860	199685	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222123	199685	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		3076002	186061	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL473099	186061	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		3076002	186061	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL473099	186061	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	4	0	5	3.0	CN1CCN(c2nc(OCc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		90645150	118950	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290573	118950	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	304	2	1	6	1.5	CN1CCN(c2nc(N)nc(-c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		25130576	194405	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		25130576	194405	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		CHEMBL494890	194405	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm8005959
		CHEMBL494890	194405	1	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	280	2	2	6	1.0	N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1	10.1021/jm800670r
		10018335	78787	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL197477	78787	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.6	CN1CCN(C(=O)c2cc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		57393771	74949	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	311	2	2	7	1.5	COc1ccc2oc3c(N4C[C@@H]5C[C@H]4CN5)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915035	74949	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	311	2	2	7	1.5	COc1ccc2oc3c(N4C[C@@H]5C[C@H]4CN5)nc(N)nc3c2c1	10.1016/j.bmcl.2011.08.014
		10545988	69921	0	None	-93	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774593	69921	0	None	-93	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789558	69921	0	None	-93	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		46228071	206957	18	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL596562	206957	18	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	283	4	1	5	1.8	CN1CCN(c2cc(NCc3ccccc3)ncn2)CC1	10.1016/j.bmc.2009.08.059
		1204	8713	119	None	-15	25	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	8713	119	None	-15	25	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	8713	119	None	-15	25	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	8713	119	None	-15	25	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	8713	119	None	-15	25	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	8713	119	None	-15	25	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		46890590	13796	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084810	13796	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		57400735	74943	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	2	6	2.9	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915026	74943	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	2	6	2.9	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(C(F)(F)F)cc3c2n1	10.1016/j.bmcl.2011.08.014
		56851441	78374	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	7	2	3	4.2	c1ccc(CN/C(=N/C2CCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923023	78374	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	7	2	3	4.2	c1ccc(CN/C(=N/C2CCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963243	78374	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	342	7	2	3	4.2	c1ccc(CN/C(=N/C2CCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		25147772	180188	9	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL452847	180188	9	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2015.12.035
		16061961	206458	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593103	206458	0	None	7	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		10381810	211953	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL7828	211953	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1	10.1021/jm051008s
		137647794	164760	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	464	8	1	6	4.2	COc1ccc2c(c1)c(CC(=O)NCCCn1ccnc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4085023	164760	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	464	8	1	6	4.2	COc1ccc2c(c1)c(CC(=O)NCCCn1ccnc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		10545988	69921	0	None	-93	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774593	69921	0	None	-93	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789558	69921	0	None	-93	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	237	8	2	3	2.0	C=CCCCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		122193096	130693	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628043	130693	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		90645154	118958	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	1.9	CN1CCN(c2nc(N)nc(-c3ccc(C(F)(F)F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290581	118958	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	1.9	CN1CCN(c2nc(N)nc(-c3ccc(C(F)(F)F)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		10777275	12667	1	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079553	12667	1	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL156005	12667	1	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		1267	10576	49	None	-33	27	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2013.06.075
		3035905	10576	49	None	-33	27	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2013.06.075
		CHEMBL260374	10576	49	None	-33	27	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2013.06.075
		127036978	144059	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752225	144059	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		164612037	192156	0	None	-81283	20	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4860528	192156	0	None	-81283	20	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		1224	8214	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		3100	8214	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		8980	8214	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		916	8214	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		CHEMBL657	8214	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		DB01075	8214	83	None	-194	13	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		9883231	120163	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.0	CN1CCN(C(=O)c2nc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL331773	120163	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	312	1	1	3	2.0	CN1CCN(C(=O)c2nc3cc(C(F)(F)F)ccc3[nH]2)CC1	10.1021/jm0502081
		1267	10576	49	None	-33	27	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.03.046
		3035905	10576	49	None	-33	27	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.03.046
		CHEMBL260374	10576	49	None	-33	27	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmc.2011.03.046
		1267	10576	49	None	-33	27	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2009.10.005
		3035905	10576	49	None	-33	27	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2009.10.005
		CHEMBL260374	10576	49	None	-33	27	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2009.10.005
		24992735	116932	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
		CHEMBL3236582	116932	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	247	2	2	5	0.7	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC3)C1	10.1021/jm401727m
		24826081	74888	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914762	74888	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	1	1	6	2.9	CN1CCN(c2nc(N)nc3c2sc2cc(Br)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		90645153	118957	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290580	118957	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	284	2	1	6	1.2	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2014.06.032
		25178344	193665	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489664	193665	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10934158	115354	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		CHEMBL320331	115354	1	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	258	5	1	3	2.8	c1ccc(COC[C@@H]2CC[C@H](c3c[nH]cn3)O2)cc1	10.1021/jm0300025
		24853593	102833	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccncc2)CC1	10.1021/jm7014217
		CHEMBL259956	102833	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccncc2)CC1	10.1021/jm7014217
		54586765	68316	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(NCCO)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770982	68316	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	252	5	4	7	-0.7	CN[C@@H]1CCN(c2cc(NCCO)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		44275465	105997	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2013.02.091
		CHEMBL281590	105997	2	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	243	1	1	5	1.0	CN1CCN(c2nc(N)nc3ccccc23)CC1	10.1016/j.bmcl.2013.02.091
		24826080	74890	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	1	1	6	3.2	CN1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914764	74890	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	367	1	1	6	3.2	CN1CCN(c2nc(N)nc3c2sc2cc(C(F)(F)F)ccc23)CC1	10.1016/j.bmcl.2011.08.014
		71519349	93266	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	6	1.8	Cn1c(-c2ccc(F)cc2)cc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		CHEMBL2314767	93266	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	326	2	2	6	1.8	Cn1c(-c2ccc(F)cc2)cc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		57393770	74946	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915031	74946	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	315	1	2	6	2.2	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		155534519	183262	0	None	-47	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	288	7	3	5	2.7	CC(C)(C)CNc1nccc(NCCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4470527	183262	0	None	-47	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	288	7	3	5	2.7	CC(C)(C)CNc1nccc(NCCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596640	183262	0	None	-47	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	288	7	3	5	2.7	CC(C)(C)CNc1nccc(NCCCc2c[nH]cn2)n1	10.1021/acs.jmedchem.9b01342
		51354873	65680	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688984	65680	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	267	6	1	4	2.2	c1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		51354874	65681	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	335	6	1	4	3.5	Clc1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1Cl	10.1021/jm1013488
		CHEMBL1688985	65681	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	335	6	1	4	3.5	Clc1ccc(Cn2cc(CCCc3c[nH]cn3)nn2)cc1Cl	10.1021/jm1013488
		168292954	199776	0	None	-112	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5202592	199776	0	None	-112	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222660	199776	0	None	-112	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		11779175	69940	0	None	-5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774600	69940	0	None	-5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789801	69940	0	None	-5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		164612760	191497	0	None	-38	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4850490	191497	0	None	-38	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		11779175	69940	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774600	69940	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789801	69940	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		58227085	123909	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393545	123909	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@H]1CCN(c2ccnc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2014.12.027
		1267	10576	49	None	-33	27	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1039/C8MD00527C
		3035905	10576	49	None	-33	27	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1039/C8MD00527C
		CHEMBL260374	10576	49	None	-33	27	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysisDisplacement of [3H]-Nalpha-Methylhistamine from human recombinant histamine H4 receptor expressed in CHO cell membranes after 1 hrs by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1039/C8MD00527C
		11846464	85235	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
		CHEMBL211170	85235	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	361	0	0	4	4.4	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3c(Cl)cccc32)CC1	10.1021/jm051008s
		118720433	122688	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	206	3	1	4	0.8	CCc1cc(N2CC[C@@H](NC)C2)ncn1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354807	122688	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	206	3	1	4	0.8	CCc1cc(N2CC[C@@H](NC)C2)ncn1	10.1016/j.bmcl.2014.10.013
		51354581	65671	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	275	10	1	4	3.1	CCCCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		CHEMBL1688973	65671	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	275	10	1	4	3.1	CCCCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		9877454	212392	2	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		CHEMBL81644	212392	2	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1ccc(Cc2c[nH]cn2)nc1	10.1021/jm049932u
		1613	9127	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		205	9127	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		3964	9127	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		CHEMBL831	9127	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		DB00408	9127	53	None	-134	44	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm051008s
		164609493	191215	0	None	-2630	6	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
		CHEMBL4846380	191215	0	None	-2630	6	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
		71518698	93268	2	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	218	1	3	5	-0.1	Nc1nc(N2CCNCC2)c2cc[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314770	93268	2	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	218	1	3	5	-0.1	Nc1nc(N2CCNCC2)c2cc[nH]c2n1	10.1016/j.bmcl.2012.10.139
		4242975	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		CHEMBL128088	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1007/s00044-004-0106-7
		4242975	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		CHEMBL128088	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0341047
		16061961	206458	0	None	7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593103	206458	0	None	7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	316	4	2	6	1.6	CN1CCN(c2cc(NCc3ccc(F)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		11258458	90228	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		CHEMBL219930	90228	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	412	6	1	4	4.5	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		57398183	74827	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	347	4	3	7	1.8	Nc1nc(N2CC[C@@H](NCCO)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914545	74827	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	347	4	3	7	1.8	Nc1nc(N2CC[C@@H](NCCO)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		4242975	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		CHEMBL128088	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1021/jm0502081
		118720438	122694	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	220	3	1	4	1.4	CN[C@@H]1CCN(c2ccnc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354814	122694	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	220	3	1	4	1.4	CN[C@@H]1CCN(c2ccnc(C(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		24854640	102834	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccccn2)CC1	10.1021/jm7014217
		CHEMBL259957	102834	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	335	4	0	6	2.4	CN1CCN(c2nc3ccccc3nc2OCc2ccccn2)CC1	10.1021/jm7014217
		135589846	148598	3	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	356	2	2	5	3.1	OCCN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL386333	148598	3	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	356	2	2	5	3.1	OCCN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1021/jm051008s
		24826439	74897	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	2	2	7	1.4	COc1cccc2oc3c(N4CCNCC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		CHEMBL1914771	74897	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	299	2	2	7	1.4	COc1cccc2oc3c(N4CCNCC4)nc(N)nc3c12	10.1016/j.bmcl.2011.08.014
		10446295	8913	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
		1277	8913	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
		CHEMBL185951	8913	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.07.114
		10446295	8913	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
		1277	8913	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL185951	8913	34	None	269	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2011.11.098
		10023327	175795	0	None	-144	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		1267	10576	49	None	-33	27	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		3035905	10576	49	None	-33	27	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		CHEMBL260374	10576	49	None	-33	27	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		155556721	181333	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	248	2	1	6	0.6	CC(C)=Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4556243	181333	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	248	2	1	6	0.6	CC(C)=Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		24854639	102910	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	5	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260458	102910	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	348	5	0	5	3.0	CN1CCN(c2nc3ccccc3nc2OCCc2ccccc2)CC1	10.1021/jm7014217
		11344458	211977	2	None	-14	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78497	211977	2	None	-14	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	187	4	1	2	2.0	c1cncc(CCCc2c[nH]cn2)c1	10.1021/jm049932u
		51354588	66945	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	6	0	5	2.1	c1c(CC2CCCCC2)nnn1CCCN1CCOCC1	10.1021/jm1013488
		CHEMBL1688980	66945	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	6	0	5	2.1	c1c(CC2CCCCC2)nnn1CCCN1CCOCC1	10.1021/jm1013488
		CHEMBL1739759	66945	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	6	0	5	2.1	c1c(CC2CCCCC2)nnn1CCCN1CCOCC1	10.1021/jm1013488
		16106	124924	34	None	-20	11	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL340801	124924	34	None	-20	11	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	10.1021/jm051008s
		46881855	14518	0	None	-15	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		CHEMBL1089040	14518	0	None	-15	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	337	3	2	5	2.5	CN[C@@H]1CCN(c2nc(N)nc3c2CCCC(c2ccccc2)C3)C1	10.1016/j.bmcl.2010.01.131
		71519014	93242	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	2	5	2.9	CC(C)N1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314499	93242	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	354	3	2	5	2.9	CC(C)N1CCN(c2nc(N)nc3[nH]c(-c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		122193094	130691	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628041	130691	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		155513612	183099	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4439142	183099	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4515149	183099	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		CHEMBL4595327	183099	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1	10.1021/acs.jmedchem.9b01342
		45379808	207998	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	362	5	2	6	1.6	CC(=O)NCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL603621	207998	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	362	5	2	6	1.6	CC(=O)NCCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		168286426	199705	0	None	-109	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5198795	199705	0	None	-109	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222241	199705	0	None	-109	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		164620139	192567	0	None	-56	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	436	8	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4866734	192567	0	None	-56	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	436	8	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		136042267	76687	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938976	76687	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		11623296	123801	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL338972	123801	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	280	1	1	3	1.2	CN1CCN(C(=O)c2nc3c(F)c(F)ccc3[nH]2)CC1	10.1021/jm0502081
		11066922	26195	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL129436	26195	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		11066922	26195	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129436	26195	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0341047
		49841845	76514	0	None	19	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935573	76514	0	None	19	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		25068753	195217	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.10.104
		CHEMBL502347	195217	19	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	295	1	2	5	1.8	Nc1nc2c(c(N3CC[C@@H](N)C3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.10.104
		1223	7740	41	None	-60	11	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm7014777
		2790	7740	41	None	-60	11	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm7014777
		CHEMBL14690	7740	41	None	-60	11	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm7014777
		1278	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		1278	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		1279	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		1279	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		4908365	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		4908365	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		CHEMBL129198	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.10.013
		CHEMBL129198	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2014.12.027
		58227086	123921	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393557	123921	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		1278	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		1279	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		4908365	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		CHEMBL129198	8931	84	None	-3	8	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm401727m
		2063135	15150	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1021/jm401727m
		CHEMBL1093180	15150	9	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	302	1	0	5	2.8	CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1	10.1021/jm401727m
		23650959	116898	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	410	7	1	4	5.3	Cc1cnc(OCCCCC2CCN(C)CC2)cc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/jm401727m
		CHEMBL3236548	116898	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	410	7	1	4	5.3	Cc1cnc(OCCCCC2CCN(C)CC2)cc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/jm401727m
		11066922	26195	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129436	26195	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1021/jm0502081
		155524115	183326	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4454158	183326	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		CHEMBL4597218	183326	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.0c00160
		70696620	82442	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	1	2	3	1.8	CN1CCN(C(=O)c2cc3cc(Cl)cc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047450	82442	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	292	1	2	3	1.8	CN1CCN(C(=O)c2cc3cc(Cl)cc(N)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		25129523	194066	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL492884	194066	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm800670r
		76311195	112828	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	284	2	2	6	1.1	CN1CCN(c2cc(-c3ccc(N)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL3133130	112828	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	284	2	2	6	1.1	CN1CCN(c2cc(-c3ccc(N)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		25129523	194066	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL492884	194066	45	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		25128824	199957	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		CHEMBL523225	199957	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		155524115	183326	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4454158	183326	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597218	183326	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	286	3	2	5	2.2	CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1	10.1021/acs.jmedchem.9b01342
		25128824	199957	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		CHEMBL523225	199957	0	None	-3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	313	1	2	5	1.8	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccc(F)cc1-2	10.1021/jm800670r
		25071004	199497	0	None	-1	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		CHEMBL521996	199497	0	None	-1	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	309	2	2	5	2.0	CN[C@@H]1CCN(c2nc(N)nc3c2CCCc2ccccc2-3)C1	10.1021/jm800670r
		11705395	22824	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		CHEMBL1223749	22824	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.6	Clc1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1Cl	10.1016/j.ejmech.2016.09.074
		24826162	74917	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914792	74917	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@@H]1CCN(c2nc(N)nc3c2sc2cc(Cl)ccc23)C1	10.1016/j.bmcl.2011.08.014
		71519674	96504	0	None	1	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	96504	0	None	1	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		46890072	13682	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084355	13682	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	404	8	2	4	4.9	Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		24994634	8923	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		8984	8923	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		CHEMBL3236549	8923	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/jm401727m
		24994634	8923	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		8984	8923	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		CHEMBL3236549	8923	31	None	2	7	Mouse	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from mouse recombinant histamine H4 receptorDisplacement of [3H]histamine from mouse recombinant histamine H4 receptor	ChEMBL	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	10.1021/acs.jmedchem.5b00516
		44129056	206379	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	474	7	1	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592663	206379	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	474	7	1	7	2.9	CN1CCN(c2nc(NCCS(=O)(=O)N(C)c3ccccc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25128822	194260	0	None	10	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		CHEMBL494093	194260	0	None	10	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1021/jm800670r
		11554490	22825	0	None	-5	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.3	FC(F)(F)c1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL1223750	22825	0	None	-5	4	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	428	7	1	4	5.3	FC(F)(F)c1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1	10.1016/j.ejmech.2016.09.074
		24797956	116907	3	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		CHEMBL3236558	116907	3	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	233	2	2	5	0.9	Nc1nc(C2CCCC2)cc(N2CC(N)C2)n1	10.1021/jm401727m
		24825514	193634	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	256	4	1	2	3.6	CC(C)(C)CC(=O)c1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		CHEMBL489493	193634	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	256	4	1	2	3.6	CC(C)(C)CC(=O)c1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		24825515	194096	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	238	2	1	1	3.4	CC(C)(C)C#Cc1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		CHEMBL493014	194096	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	238	2	1	1	3.4	CC(C)(C)C#Cc1cccc(Cc2c[nH]cn2)c1	10.1021/jm7014149
		11301441	102929	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm800876b
		CHEMBL260549	102929	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm800876b
		11301441	102929	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm7014217
		CHEMBL260549	102929	10	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1021/jm7014217
		24825791	74830	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914548	74830	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		25109291	198165	10	None	-501	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	198165	10	None	-501	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		45379922	206342	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	552	7	2	7	2.8	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(I)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL592434	206342	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	552	7	2	7	2.8	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3cc(I)ccc3n2)CC1	10.1021/jm901379s
		54585777	68308	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	5	3	5	2.1	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770974	68308	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	297	5	3	5	2.1	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)c2)C1	10.1016/j.bmcl.2011.03.017
		118720441	122698	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	3	4	2.5	Nc1cc(C2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354819	122698	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	3	4	2.5	Nc1cc(C2CCNCC2)cc(NC2CCCC2)n1	10.1016/j.bmcl.2014.10.013
		24826518	74879	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2cccc(C(F)(F)F)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914753	74879	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	2.7	CN1CCN(c2nc(N)nc3c2oc2cccc(C(F)(F)F)c23)CC1	10.1016/j.bmcl.2011.08.014
		1278	8931	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		1279	8931	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		4908365	8931	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		CHEMBL129198	8931	84	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H4 receptorBinding affinity to histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2009.08.059
		136192886	63254	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632411	63254	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	257	2	2	3	2.7	CN1CCC(/C(=N/O)c2cc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		136141537	63255	3	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632412	63255	3	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	271	2	2	3	3.0	Cc1ccc2[nH]c(/C(=N\O)C3CCN(C)CC3)cc2c1	10.1016/j.bmcl.2010.10.041
		71525678	96500	0	None	-5	6	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	96500	0	None	-5	6	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		1267	10576	49	None	-14	27	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		3035905	10576	49	None	-14	27	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		CHEMBL260374	10576	49	None	-14	27	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm100064d
		1223	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1269	6909	41	None	213	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
		37463	6909	41	None	213	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL275443	6909	41	None	213	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1016/j.bmcl.2010.10.041
		1255	9969	19	None	-12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
		6421522	9969	19	None	-12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
		CHEMBL19173	9969	19	None	-12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	216	6	1	2	2.6	C(CCc1cnc[nH]1)OCc1ccccc1	10.1016/j.bmcl.2010.10.041
		10017000	211264	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
		CHEMBL72431	211264	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	288	7	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCc1ccccc1	10.1016/j.bmcl.2010.10.041
		1223	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		1223	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		2790	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		CHEMBL14690	7740	41	None	-60	11	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]JNJ7777120 from human H4 receptor E5.46Q mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/jm201042n
		71681644	96442	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	412	9	4	8	3.8	CC(C)CNc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375767	96442	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	412	9	4	8	3.8	CC(C)CNc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		71681805	96447	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	426	9	3	8	3.8	CC(C)CNc1nccc(NCCN(C)c2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375771	96447	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	426	9	3	8	3.8	CC(C)CNc1nccc(NCCN(C)c2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		11506928	81217	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	2	2	3.0	c1nc(CCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL202728	81217	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	235	6	2	2	3.0	c1nc(CCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		11600779	82823	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205731	82823	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	7	2	2	1.7	CCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		11536119	145485	0	None	-15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	249	7	2	2	3.4	c1nc(CCCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL377954	145485	0	None	-15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	249	7	2	2	3.4	c1nc(CCCCCNC2CCCCCC2)c[nH]1	10.1021/jm0504353
		4242975	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		CHEMBL128088	25614	9	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	1	1	2	1.9	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1016/j.ejmech.2012.06.016
		45379921	205982	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	426	6	1	7	3.6	CN1CCN(c2nc(NCCc3ccc([N+](=O)[O-])cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL589800	205982	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	426	6	1	7	3.6	CN1CCN(c2nc(NCCc3ccc([N+](=O)[O-])cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		9972181	201996	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	8	3	3	3.2	N=C(NCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202331	201996	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	8	3	3	3.2	N=C(NCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL550757	201996	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	302	8	3	3	3.2	N=C(NCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		10063835	69897	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774601	69897	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789356	69897	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		46890200	13932	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	442	9	1	4	5.4	CN(C)CCN(C)CCCOc1ccc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)cc1Cl	10.1016/j.bmcl.2010.04.017
		CHEMBL1085403	13932	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	442	9	1	4	5.4	CN(C)CCN(C)CCCOc1ccc(-c2nc3cc(C(C)(C)C)ccc3[nH]2)cc1Cl	10.1016/j.bmcl.2010.04.017
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-15	25	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-15	25	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-15	25	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-15	25	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-15	25	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-15	25	Mouse	6.3	pKi	=	6.3	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1267	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		71681803	96391	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)ncn1	10.1021/jm301886t
		CHEMBL2375363	96391	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1cc(NCCNc2cc(-c3ccccc3)nc(N)n2)ncn1	10.1021/jm301886t
		11672774	10833	11	None	-31	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	1	2	1.7	CN(CCCCCc1[nH]cnc1)C	10.1021/jm0504353
		1245	10833	11	None	-31	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	1	2	1.7	CN(CCCCCc1[nH]cnc1)C	10.1021/jm0504353
		CHEMBL206548	10833	11	None	-31	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	181	6	1	2	1.7	CN(CCCCCc1[nH]cnc1)C	10.1021/jm0504353
		11564628	82306	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	193	5	1	2	1.8	c1nc(CCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL204360	82306	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	193	5	1	2	1.8	c1nc(CCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		11629931	83086	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	5	1	2	2.6	c1nc(CCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL205868	83086	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	221	5	1	2	2.6	c1nc(CCCCN2CCCCCC2)c[nH]1	10.1021/jm0504353
		70686222	82456	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	2	2	2	1.7	CN[C@@H]1CCN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047464	82456	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	261	2	2	2	1.7	CN[C@@H]1CCN(C(=O)c2cc3cccc(F)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		135398737	7745	93	None	-57	90	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		38	7745	93	None	-57	90	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		722	7745	93	None	-57	90	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		CHEMBL42	7745	93	None	-57	90	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		DB00363	7745	93	None	-57	90	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD20212C
		44395314	130464	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	2	2	2	3.2	CN1CCC(C(O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL362163	130464	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	2	2	2	3.2	CN1CCC(C(O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		126688	7192	33	None	1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
		4025	7192	33	None	1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
		CHEMBL293762	7192	33	None	1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
		66572110	82418	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047269	82418	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	285	2	1	3	1.8	CC(=O)c1cccc2[nH]c(C(=O)N3CCN(C)CC3)cc12	10.1016/j.ejmech.2012.06.016
		70684085	82449	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	325	1	1	2	3.0	CN1CCCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047457	82449	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	325	1	1	2	3.0	CN1CCCN(C(=O)c2cc3cccc(C(F)(F)F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10063835	69897	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774601	69897	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789356	69897	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	9	2	3	3.8	O=C(NCCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		206876	25717	7	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1039/C2MD20212C
		CHEMBL128637	25717	7	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	273	2	1	3	1.6	COc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1	10.1039/C2MD20212C
		57395620	74991	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915534	74991	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.125
		57395620	74991	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915534	74991	0	None	15	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		90645160	118964	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3c(F)cccc3F)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290587	118964	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	306	2	1	6	1.2	CN1CCN(c2nc(N)nc(-c3c(F)cccc3F)n2)CC1	10.1016/j.ejmech.2014.06.032
		57390145	76681	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938970	76681	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	290	1	2	3	1.5	O=C(c1nc2cc(Cl)ccc2[nH]1)N1C[C@@H]2CNC[C@@H]2C1	10.1016/j.bmcl.2011.11.098
		49865668	22823	0	None	-51	4	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	390	8	1	5	4.3	COc1ccccc1N1CCN(CCCCNc2nccc3ccccc23)CC1	10.1016/j.ejmech.2016.09.074
		CHEMBL1223748	22823	0	None	-51	4	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	390	8	1	5	4.3	COc1ccccc1N1CCN(CCCCNc2nccc3ccccc23)CC1	10.1016/j.ejmech.2016.09.074
		54586764	68312	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N(C)C(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770978	68312	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	4	2	6	0.7	CN[C@@H]1CCN(c2cc(N(C)C(C)C)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		44546966	123889	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	4	1	4	1.9	CC(C)CNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393525	123889	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	4	1	4	1.9	CC(C)CNc1cc(N2CCN(C)CC2)ccn1	10.1016/j.bmcl.2014.12.027
		9964223	212466	11	None	-36	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL82244	212466	11	None	-36	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	173	3	1	2	1.6	c1cncc(CCc2c[nH]cn2)c1	10.1021/jm049932u
		90645148	118952	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290575	118952	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	295	2	1	7	0.7	CN1CCN(c2nc(N)nc(-c3cccc(C#N)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		56950378	76643	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		CHEMBL1938845	76643	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	302	1	1	3	1.6	Cc1c(F)ccc2[nH]c(C(=O)N3C[C@@H]4CN(C)C[C@@H]4C3)nc12	10.1016/j.bmcl.2011.11.098
		25071940	194133	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		CHEMBL493281	194133	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		90645145	118955	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL3290578	118955	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		66741667	116915	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		CHEMBL3236566	116915	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		122194623	130797	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	296	3	1	6	1.4	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629826	130797	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	296	3	1	6	1.4	CN1CCN(c2nc(N)nc(/C=C/c3ccccc3)n2)CC1	10.1016/j.ejmech.2015.08.014
		90645145	118955	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290578	118955	0	None	28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	348	2	1	6	1.6	CN1CCN(c2nc(N)nc(-c3ccc(Br)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		10083861	22279	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)nc2c1	10.1021/jm0502081
		CHEMBL121679	22279	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	1	3	1.3	Cc1ccc2[nH]c(C(=O)N3CCN(C)CC3)nc2c1	10.1021/jm0502081
		121238067	173890	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4290148	173890	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		57394636	74821	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	284	1	0	5	2.6	CN1CCN(c2ncnc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914534	74821	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	284	1	0	5	2.6	CN1CCN(c2ncnc3c2sc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		71525587	96502	0	None	177	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	255	2	2	7	-0.1	CNC1CN(c2nc(N)nc3cc(C#N)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376802	96502	0	None	177	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	255	2	2	7	-0.1	CNC1CN(c2nc(N)nc3cc(C#N)cnc23)C1	10.1016/j.bmcl.2013.02.091
		753256	186129	12	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL473662	186129	12	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	208	1	2	6	-0.6	CN1CCN(c2cc(N)nc(N)n2)CC1	10.1016/j.bmcl.2012.10.139
		46228143	206862	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL595880	206862	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	343	5	2	8	1.3	CN1CCN(c2cc(NCc3cccc([N+](=O)[O-])c3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		24745335	7083	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	7083	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	7083	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	7083	12	None	-6	5	Mouse	7.3	pKi	=	7.3	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		24745335	7083	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		8985	7083	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		CHEMBL1915540	7083	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		DB15027	7083	12	None	-4	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2013.02.091
		51354583	65673	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.1	c1nc(CCCn2cc(CC3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688975	65673	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	287	6	1	4	3.1	c1nc(CCCn2cc(CC3CCCCCC3)nn2)c[nH]1	10.1021/jm1013488
		71518860	93271	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	2	2	5	2.0	CN1CCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314773	93271	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	308	2	2	5	2.0	CN1CCN(c2nc(N)nc3[nH]c(-c4ccccc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		46228113	208852	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	328	5	2	7	1.4	COc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		CHEMBL608717	208852	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	328	5	2	7	1.4	COc1ccc(CNc2cc(N3CCN(C)CC3)nc(N)n2)cc1	10.1016/j.bmc.2009.08.059
		164611807	191763	0	None	-162	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4854278	191763	0	None	-162	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		49841718	76510	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)cc1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935569	76510	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2ccc3c(N4CCN(C)CC4)nc(N)nc3c2)cc1	10.1016/j.bmcl.2011.10.104
		58227143	123905	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393541	123905	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	1	5	1.4	CCCCNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		67087450	123914	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393550	123914	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	5	2	5	1.3	CN[C@@H]1CCN(c2cnnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		46890071	13681	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.7	Cc1cc(OCCCNCC2CCCN(C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1084354	13681	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	424	8	2	4	4.7	Cc1cc(OCCCNCC2CCCN(C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		66740470	116575	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		CHEMBL3233048	116575	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	289	2	2	6	0.9	Nc1nc(C2CCCC2)cc(N2C[C@H]3NCCO[C@@H]3C2)n1	10.1021/jm401727m
		2306318	93783	12	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL232421	93783	12	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	268	1	0	5	2.1	CN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1016/j.bmcl.2011.08.014
		121238068	163989	0	None	-281	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	1	6	2.0	CN1CCN(c2nc(N)nc(Cc3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4076046	163989	0	None	-281	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	334	3	1	6	2.0	CN1CCN(c2nc(N)nc(Cc3cccc4ccccc34)n2)CC1	10.1016/j.ejmech.2017.09.035
		25178341	193588	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489271	193588	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178341	193588	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489271	193588	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	382	4	2	6	3.2	CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		25178556	195864	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL509961	195864	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	423	4	1	6	4.9	CN1CCN(c2nc(NCc3cc4ccccc4s3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		23649429	103072	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	2	0	5	2.7	COc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL261224	103072	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	326	2	0	5	2.7	COc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		44478385	12548	6	None	9	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
		CHEMBL1078642	12548	6	None	9	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
		25178344	193665	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489664	193665	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	321	4	2	6	1.4	CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		24853597	103071	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1cccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)c1	10.1021/jm7014217
		CHEMBL261223	103071	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	334	3	0	5	3.5	Cc1cccc(Oc2nc3ccccc3nc2N2CCN(C)CC2)c1	10.1021/jm7014217
		8070044	162731	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	300	4	0	5	2.4	CC(C)COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL406123	162731	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	300	4	0	5	2.4	CC(C)COc1nc2ccccc2nc1N1CCN(C)CC1	10.1021/jm7014217
		16061844	68315	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(NCc3ccccc3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770981	68315	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(NCc3ccccc3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		57403351	75098	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2cc(NCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916499	75098	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN(C)[C@@H]1CCN(c2cc(NCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		156011443	185120	0	None	-50	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	387	8	1	2	4.7	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4636487	185120	0	None	-50	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	387	8	1	2	4.7	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4651225	185120	0	None	-50	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	387	8	1	2	4.7	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		25178339	193562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489061	193562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		51354585	65675	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	245	5	1	4	2.0	c1nc(CCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688977	65675	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	245	5	1	4	2.0	c1nc(CCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		51354876	66974	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1739924	66974	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL3216267	66974	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		12741697	102935	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		CHEMBL260565	102935	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		25178339	193562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489061	193562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	5	4.0	CN1CCN(c2nc(NCC3CCCCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		919019	143510	7	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2[nH]c3c(N4CCN(C)CC4)ncnc3c2c1	10.1039/C5MD00022J
		CHEMBL3740837	143510	7	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2[nH]c3c(N4CCN(C)CC4)ncnc3c2c1	10.1039/C5MD00022J
		929854	205864	8	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	289	4	2	4	2.7	CN(C)CCNc1ncnc2c1[nH]c1ccc(Cl)cc12	10.1039/C5MD00022J
		CHEMBL588176	205864	8	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	289	4	2	4	2.7	CN(C)CCNc1ncnc2c1[nH]c1ccc(Cl)cc12	10.1039/C5MD00022J
		168278543	199630	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184846	199630	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221764	199630	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168295803	199824	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207206	199824	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222937	199824	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		57402471	74651	0	None	-549	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910378	74651	0	None	-549	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		164614645	191911	0	None	-57	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		CHEMBL4856572	191911	0	None	-57	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		57394627	75096	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	5	2	5	2.4	CN1CC[C@H](Nc2cc(NCCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916497	75096	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	5	2	5	2.4	CN1CC[C@H](Nc2cc(NCCC(C)(C)C)ncn2)C1	10.1016/j.bmcl.2011.07.114
		71519179	93261	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	3	4	5	2.1	Nc1nc(N[C@H]2CCNC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314762	93261	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	3	4	5	2.1	Nc1nc(N[C@H]2CCNC2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		1204	8713	119	None	1	25	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	8713	119	None	1	25	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	8713	119	None	1	25	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	8713	119	None	1	25	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	8713	119	None	1	25	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	8713	119	None	1	25	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity to guinea pig histamine H4 receptorBinding affinity to guinea pig histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1278	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1279	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		4908365	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL129198	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1278	8931	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		1279	8931	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		4908365	8931	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		CHEMBL129198	8931	84	None	3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.10.104
		44538833	76494	26	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@H]2CCCC[C@H]2O1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935450	76494	26	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@H]2CCCC[C@H]2O1	10.1016/j.bmcl.2011.10.104
		49841719	76512	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935571	76512	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		11846300	87041	3	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL213912	87041	3	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2011.10.104
		11301441	102929	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL260549	102929	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	312	1	1	4	2.0	CN1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]c2=O)CC1	10.1016/j.bmcl.2011.10.104
		54582865	68293	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770959	68293	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(N)nc(NC3CCCC3)n2)C1	10.1016/j.bmcl.2011.03.017
		54584825	68324	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770990	68324	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2011.03.017
		25130912	195518	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		CHEMBL505061	195518	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	2	1	6	0.4	CN1CCN(c2cc(N3CCCC3)nc(N)n2)CC1	10.1016/j.bmcl.2011.03.017
		54584825	68324	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL1770990	68324	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	250	4	3	6	0.7	CN[C@@H]1CCN(c2cc(N)nc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		58227157	122695	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354815	122695	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.10.013
		58227200	123899	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393535	123899	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	286	4	2	4	2.5	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		58227337	123917	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393553	123917	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	4	2	5	1.6	CN[C@@H]1CCN(c2cnnc(NC3CCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		24745335	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		8985	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		CHEMBL1915540	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		DB15027	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human H4R expressed in HEK293T cellsDisplacement of [3H]-histamine from human H4R expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1016/j.bmcl.2011.07.125
		24745335	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		8985	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		CHEMBL1915540	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		DB15027	7083	12	None	4	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	10.1021/acs.jmedchem.5b00516
		11957573	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1250	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		3692	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL19439	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		44595856	96432	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375757	96432	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	356	6	4	8	2.3	Nc1nccc(NCCNc2cc(-c3cccc(Cl)c3)nc(N)n2)n1	10.1021/jm301886t
		1278	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		1279	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		4908365	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		CHEMBL129198	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm301886t
		11957573	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		1250	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		3692	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		CHEMBL19439	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1021/jm201042n
		25129523	194066	45	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL492884	194066	45	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1016/j.bmcl.2011.06.123
		1278	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		1279	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		4908365	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		CHEMBL129198	8931	84	None	-3	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.ejmech.2012.06.016
		11066922	26195	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL129436	26195	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	311	1	1	2	2.9	CN1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573458	82439	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047447	82439	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3c(F)c(Cl)ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573459	82440	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047448	82440	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	295	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		9860842	82441	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)cc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047449	82441	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	1	1	2	2.5	Cc1cc(Cl)cc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1016/j.ejmech.2012.06.016
		11957573	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		1250	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		3692	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		CHEMBL19439	8791	34	None	-40	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	10.1016/j.bmc.2009.04.007
		71525681	96503	0	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	96503	0	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		136042270	76690	0	None	426	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938979	76690	0	None	426	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	269	1	2	3	1.4	CN1C[C@H]2CN(C(=N)c3nc4ccccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.04.017
		25178552	180190	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452848	180190	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178552	180190	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL452848	180190	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	387	5	1	6	3.8	CN1CCN(c2nc(NCCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		90645158	118962	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(Cl)cc1-c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290585	118962	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	334	3	1	7	1.5	COc1ccc(Cl)cc1-c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2014.06.032
		57399828	75102	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	345	5	1	5	3.8	CC(C)(C)CCNc1cc(N2CCN(C3CCCCC3)CC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916502	75102	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	345	5	1	5	3.8	CC(C)(C)CCNc1cc(N2CCN(C3CCCCC3)CC2)ncn1	10.1016/j.bmcl.2011.07.114
		805994	181134	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL455133	181134	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm800876b
		805994	181134	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL455133	181134	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	323	4	1	6	2.6	CN1CCN(c2nc(NCc3ccco3)c3ccccc3n2)CC1	10.1021/jm901379s
		168286141	199703	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5192993	199703	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222231	199703	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		46890167	14030	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN1CCC(N(C)CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		CHEMBL1085872	14030	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	454	7	1	4	5.6	CN1CCC(N(C)CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)C1	10.1016/j.bmcl.2010.04.017
		9966927	25647	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128252	25647	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		9966927	25647	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128252	25647	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0341047
		9966927	25647	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128252	25647	5	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cccc(Br)c3[nH]2)CC1	10.1021/jm0502081
		12686479	168574	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1021/jm7014217
		CHEMBL414183	168574	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1021/jm7014217
		1265	7729	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmc.2011.03.046
		6422124	7729	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmc.2011.03.046
		CHEMBL14638	7729	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmc.2011.03.046
		1265	7729	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmcl.2009.10.005
		6422124	7729	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmcl.2009.10.005
		CHEMBL14638	7729	60	None	-2290	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1016/j.bmcl.2009.10.005
		57390262	74960	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	290	1	2	7	1.2	Nc1nc(N2CC(N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915050	74960	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	290	1	2	7	1.2	Nc1nc(N2CC(N)C2)c2oc3ncc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		155552102	183342	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	3	3	5	1.0	CC(C)(C)CNc1nccc(N2CCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4576393	183342	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	3	3	5	1.0	CC(C)(C)CNc1nccc(N2CCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4597352	183342	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	3	3	5	1.0	CC(C)(C)CNc1nccc(N2CCN(C(=N)N)CC2)n1	10.1021/acs.jmedchem.9b01342
		25178936	193561	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL489060	193561	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25178936	193561	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL489060	193561	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	305	2	0	5	2.1	CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		137646103	164685	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	393	8	3	3	3.7	O=C(O)C(Cc1cccc2ccccc12)NC(=O)[C@@H](CS)Cc1ccccc1	10.1016/j.ejmech.2016.09.074
		CHEMBL4084275	164685	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting methodAntagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta scintillation counting method	ChEMBL	393	8	3	3	3.7	O=C(O)C(Cc1cccc2ccccc12)NC(=O)[C@@H](CS)Cc1ccccc1	10.1016/j.ejmech.2016.09.074
		42624149	116917	1	None	-3	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236568	116917	1	None	-3	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from mouse histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	221	3	2	5	0.4	CCc1cc(N2CC[C@@H](NC)C2)nc(N)n1	10.1021/jm401727m
		58227127	123907	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393543	123907	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2ccnc(NC3CCCC3)n2)CC1	10.1016/j.bmcl.2014.12.027
		1204	8713	119	None	-12	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	8713	119	None	-12	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	8713	119	None	-12	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	8713	119	None	-12	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	8713	119	None	-12	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	8713	119	None	-12	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		44395308	73602	0	None	39	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	369	1	1	2	2.2	CN1CCN(C(=O)c2cc3cc(I)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		CHEMBL186108	73602	0	None	39	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	369	1	1	2	2.2	CN1CCN(C(=O)c2cc3cc(I)ccc3[nH]2)CC1	10.1016/j.bmcl.2004.08.035
		155552061	183257	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4543119	183257	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596606	183257	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	277	3	1	5	2.1	CN1CCCN(c2ccnc(NCC(C)(C)C)n2)CC1	10.1021/acs.jmedchem.9b01342
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19 measured after 60 mins by microbeta scintillation counting method	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS19	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		10017821	110563	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
		CHEMBL308913	110563	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	302	8	3	2	2.4	S=C(NCCCCc1c[nH]cn1)NCCc1ccccc1	10.1016/j.bmcl.2010.10.041
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenates	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1204	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1247	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1375	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		774	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL90	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		DB05381	8713	119	None	-3	25	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesDisplacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranes	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.0c00160
		10023327	175795	0	None	-144	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL43934	175795	0	None	-144	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor V3.40A mutant expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	390	7	2	3	5.2	Clc1ccc(CN/C(=N\C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		11499454	81195	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	6	2	2	2.5	CC(C)(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL202638	81195	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	6	2	2	2.5	CC(C)(C)NCCCCCc1c[nH]cn1	10.1021/jm0504353
		10446240	81773	1	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	277	8	2	2	3.6	Clc1ccc(CNCCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		CHEMBL203263	81773	1	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	277	8	2	2	3.6	Clc1ccc(CNCCCCCc2c[nH]cn2)cc1	10.1021/jm0504353
		11622495	83352	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL206303	83352	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	8	2	2	2.1	CCCCNCCCCc1c[nH]cn1	10.1021/jm0504353
		1267	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.ejmech.2014.03.014
		3035905	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.ejmech.2014.03.014
		CHEMBL260374	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.ejmech.2014.03.014
		12686479	168574	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL414183	168574	2	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	244	1	1	5	1.1	CN1CCN(c2nc3ccccc3nc2O)CC1	10.1016/j.bmcl.2011.06.123
		25129523	194066	45	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL492884	194066	45	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1039/C2MD20212C
		25129527	194193	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL493720	194193	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from human histamine H4 receptor L175'5.39V mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	303	2	1	5	2.1	CN1CCN(c2cc(-c3ccc(Cl)cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		70681962	82459	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.3	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCNCC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047467	82459	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	277	1	2	2	2.3	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCNCC1	10.1016/j.ejmech.2012.06.016
		70688339	82460	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047468	82460	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	309	1	1	2	2.7	CN1CCCN(C(=O)c2cc3cc(Cl)cc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		1267	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
		3035905	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
		CHEMBL260374	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm1013488
		1267	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014217
		1267	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm901379s
		3035905	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014217
		3035905	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm901379s
		CHEMBL260374	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm7014217
		CHEMBL260374	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm901379s
		24854635	103117	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	310	1	0	4	3.0	Cc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		CHEMBL261519	103117	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	310	1	0	4	3.0	Cc1nc2cc(Cl)c(Cl)cc2nc1N1CCN(C)CC1	10.1021/jm7014217
		10085528	201973	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	7	3	3	2.8	N=C(NCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL1202330	201973	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	7	3	3	2.8	N=C(NCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL550570	201973	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	288	7	3	3	2.8	N=C(NCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		10041484	202029	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	316	9	3	3	3.6	N=C(NCCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		CHEMBL551047	202029	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting	ChEMBL	316	9	3	3	3.6	N=C(NCCCCc1ccccc1)SCCCc1c[nH]cn1	10.1016/j.bmc.2009.04.007
		1267	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-33	27	Human	7.2	pKi	=	7.2	Binding	Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayDisplacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		1252	8798	21	None	-100	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		9793868	8798	21	None	-100	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL417096	8798	21	None	-100	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting methodDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes measured after 60 mins by microbeta scintillation counting method	ChEMBL	153	5	2	2	1.1	NCCCCCc1cnc[nH]1	10.1021/acs.jmedchem.0c00160
		71681641	96439	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	350	8	4	8	2.2	CC(C)CCc1cc(NCCNc2cc(Cl)nc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375764	96439	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	350	8	4	8	2.2	CC(C)CCc1cc(NCCNc2cc(Cl)nc(N)n2)nc(N)n1	10.1021/jm301886t
		11492189	82781	0	None	-10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	1	2	2.5	CCN(CC)CCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205511	82781	0	None	-10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	209	8	1	2	2.5	CCN(CC)CCCCCc1c[nH]cn1	10.1021/jm0504353
		14712103	68659	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	201	5	2	2	1.7	c1ccc(CNCCc2c[nH]cn2)cc1	10.1016/j.bmcl.2011.06.123
		CHEMBL17740	68659	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	201	5	2	2	1.7	c1ccc(CNCCc2c[nH]cn2)cc1	10.1016/j.bmcl.2011.06.123
		12741697	102935	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL260565	102935	2	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	0	3	2.6	CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2011.06.123
		9793921	71902	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	164	2	1	1	2.5	c1nc(CC2CCCCC2)c[nH]1	10.1016/j.bmcl.2011.06.123
		CHEMBL1824228	71902	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	164	2	1	1	2.5	c1nc(CC2CCCCC2)c[nH]1	10.1016/j.bmcl.2011.06.123
		24764570	82436	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	2	1.9	CN[C@@H]1CCN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047444	82436	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	257	2	2	2	1.9	CN[C@@H]1CCN(C(=O)c2cc3cccc(C)c3[nH]2)C1	10.1016/j.ejmech.2012.06.016
		25178938	193538	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm901379s
		CHEMBL488885	193538	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm901379s
		933006	143351	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2c(c1)[nH]c1c(N3CCN(C)CC3)ncnc12	10.1039/C5MD00022J
		CHEMBL3739430	143351	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	297	2	1	5	1.9	COc1ccc2c(c1)[nH]c1c(N3CCN(C)CC3)ncnc12	10.1039/C5MD00022J
		10419556	12130	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106913	12130	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		168273549	199582	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174342	199582	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221438	199582	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		66572103	82410	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cnccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047261	82410	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	244	1	1	3	1.0	CN1CCN(C(=O)c2cc3cnccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		164627020	193187	0	None	-144	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	422	7	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4876025	193187	0	None	-144	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	422	7	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		10515993	12733	1	None	-27	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079918	12733	1	None	-27	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL154944	12733	1	None	-27	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	267	9	2	3	3.0	CCCCC[C@@H](C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		54587792	68328	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.2	Nc1nc(N2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770994	68328	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.2	Nc1nc(N2CCCC2)cc(N2CC[C@@H](N)C2)n1	10.1016/j.bmcl.2011.03.017
		90645156	118960	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	313	3	1	7	0.9	CN1CCN(c2nc(N)nc(-c3ccc(N(C)C)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290583	118960	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	313	3	1	7	0.9	CN1CCN(c2nc(N)nc(-c3ccc(N(C)C)cc3)n2)CC1	10.1016/j.ejmech.2014.06.032
		763018	143512	10	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	6	1.3	Cc1nnc2c(N3CCN(C)CC3)nc3ccccc3n12	10.1039/C5MD00022J
		CHEMBL3740846	143512	10	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	282	1	0	6	1.3	Cc1nnc2c(N3CCN(C)CC3)nc3ccccc3n12	10.1039/C5MD00022J
		44414498	86771	0	None	-173	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	7	0	2	6.9	CN(Cc1ccc(-c2ccc(CN(C)C3CCCCC3)cc2)cc1)C1CCCCC1	10.1016/j.bmc.2008.10.029
		CHEMBL212775	86771	0	None	-173	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	404	7	0	2	6.9	CN(Cc1ccc(-c2ccc(CN(C)C3CCCCC3)cc2)cc1)C1CCCCC1	10.1016/j.bmc.2008.10.029
		44414433	146307	0	None	-8	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	352	13	2	2	5.9	CCCCCNCc1ccc(-c2ccc(CNCCCCC)cc2)cc1	10.1016/j.bmc.2008.10.029
		CHEMBL379545	146307	0	None	-8	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]RAMHA from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	352	13	2	2	5.9	CCCCCNCc1ccc(-c2ccc(CNCCCCC)cc2)cc1	10.1016/j.bmc.2008.10.029
		10419556	12130	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106913	12130	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		164623155	192354	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	352	3	4	4	3.4	N/C(=N\C(=O)Nc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4863393	192354	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	352	3	4	4	3.4	N/C(=N\C(=O)Nc1ccccc1)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		57395260	76504	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2nc(N)nc(N3CCN(C)CC3)c2c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935563	76504	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1ccc2nc(N)nc(N3CCN(C)CC3)c2c1	10.1016/j.bmcl.2011.10.104
		11408069	91039	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		CHEMBL221211	91039	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2010.04.017
		11408069	91039	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL221211	91039	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)cc2Cl)CC1	10.1016/j.bmcl.2006.08.117
		24825995	74920	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914795	74920	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	377	2	2	6	3.0	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Br)cc23)C1	10.1016/j.bmcl.2011.08.014
		1267	10576	49	None	-21	27	Mouse	7.2	pKi	=	7.2	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-21	27	Mouse	7.2	pKi	=	7.2	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-21	27	Mouse	7.2	pKi	=	7.2	Binding	Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		762810	206686	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	262	2	0	5	2.0	CCc1cc2c(N3CCN(C)CC3)ncnc2s1	10.1016/j.bmc.2009.08.059
		CHEMBL594730	206686	11	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	262	2	0	5	2.0	CCc1cc2c(N3CCN(C)CC3)ncnc2s1	10.1016/j.bmc.2009.08.059
		51354299	65662	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	247	8	1	4	2.4	CCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		CHEMBL1688945	65662	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	247	8	1	4	2.4	CCCCCc1cn(CCCc2c[nH]cn2)nn1	10.1021/jm1013488
		136773074	164144	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		CHEMBL4077914	164144	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	335	6	2	4	3.6	COc1ccc(/C(=N/[C@H](C)Cc2cnc[nH]2)c2ccccc2)c(O)c1	10.1016/j.ejmech.2016.09.074
		57400473	76502	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935561	76502	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	361	3	1	6	2.8	CC(=O)c1cccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)c1	10.1016/j.bmcl.2011.10.104
		57397301	74655	0	None	-891	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910382	74655	0	None	-891	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		127026018	144270	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753985	144270	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		73346048	98642	0	None	-15	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	7	2	3	3.0	O=C(NCCc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL2413359	98642	0	None	-15	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	307	7	2	3	3.0	O=C(NCCc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		164617783	191369	0	None	-104	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848815	191369	0	None	-104	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		71519499	93267	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	1	6	2.1	CN1CCN(c2nc(N)nc3c2cc(-c2ccc(F)cc2)n3C)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314768	93267	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	340	2	1	6	2.1	CN1CCN(c2nc(N)nc3c2cc(-c2ccc(F)cc2)n3C)CC1	10.1016/j.bmcl.2012.10.139
		54583872	68294	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770960	68294	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	298	5	3	6	1.5	CN[C@@H]1CCN(c2cc(N)nc(NCc3ccccc3)n2)C1	10.1016/j.bmcl.2011.03.017
		1278	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		1279	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		4908365	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		CHEMBL129198	8931	84	None	-3	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/acs.jmedchem.6b00120
		58227388	123902	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393538	123902	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	249	4	1	5	1.3	CC(C)CNc1nccc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2014.12.027
		155517880	183446	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	183446	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	183446	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		155517880	183446	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4445423	183446	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4598198	183446	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 40 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	291	4	4	5	1.0	CC(C)(C)CNc1nccc(N2CC[C@@H](NC(=N)N)C2)n1	10.1021/acs.jmedchem.9b01342
		46890626	13360	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@@H]3CCCN[C@@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083097	13360	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	422	6	2	4	4.4	Cc1cc(OCCCN2C[C@@H]3CCCN[C@@H]3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		25178938	193538	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm800876b
		CHEMBL488885	193538	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	271	2	1	5	1.7	CNc1nc(N2CCN(C)CC2)nc2cccc(C)c12	10.1021/jm800876b
		9812843	212023	1	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		CHEMBL78838	212023	1	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	159	2	1	2	1.4	c1cncc(Cc2c[nH]cn2)c1	10.1021/jm049932u
		647957	35850	13	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	2	0	6	0.4	Cc1cc(N2CCN(C)CC2)nc(N2CCOCC2)n1	10.1039/C5MD00022J
		CHEMBL1381010	35850	13	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	277	2	0	6	0.4	Cc1cc(N2CCN(C)CC2)nc(N2CCOCC2)n1	10.1039/C5MD00022J
		747187	143416	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	249	4	1	3	2.8	Cc1cc2nc(SCCN(C)C)[nH]c2cc1C	10.1039/C5MD00022J
		CHEMBL3739949	143416	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis	ChEMBL	249	4	1	3	2.8	Cc1cc2nc(SCCN(C)C)[nH]c2cc1C	10.1039/C5MD00022J
		168268716	199541	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5170276	199541	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221176	199541	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168268853	199564	0	None	-83	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5180504	199564	0	None	-83	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221353	199564	0	None	-83	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		5013	107013	32	None	-16	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2ccc3ccccc3n2)CC1	10.1021/jm7014217
		CHEMBL288591	107013	32	None	-16	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	227	1	0	3	2.0	CN1CCN(c2ccc3ccccc3n2)CC1	10.1021/jm7014217
		10243990	12666	0	None	-79	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCCC(C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079552	12666	0	None	-79	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCCC(C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL155830	12666	0	None	-79	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	253	8	2	3	2.6	CCCCC(C)NC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		11065080	26206	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1007/s00044-004-0106-7
		CHEMBL129488	26206	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1007/s00044-004-0106-7
		11065080	26206	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0341047
		CHEMBL129488	26206	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0341047
		117724523	123893	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393529	123893	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	6	2	4	2.1	CCCCNc1cc(N2CC[C@@H](NC)C2)ccn1	10.1016/j.bmcl.2014.12.027
		11594278	21462	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		CHEMBL120591	21462	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	276	1	1	3	1.4	Cc1c(F)ccc2[nH]c(C(=O)N3CCN(C)CC3)nc12	10.1021/jm0502081
		11065080	26206	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		CHEMBL129488	26206	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	257	1	1	2	1.9	Cc1cccc2cc(C(=O)N3CCN(C)CC3)[nH]c12	10.1021/jm0502081
		44462956	12371	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		CHEMBL1077276	12371	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	2	2	5	3.1	Nc1nc2c(c(N3CC4CCCNC4C3)n1)CCCCC2c1ccccc1	10.1016/j.bmcl.2010.01.131
		71603140	96494	0	None	97	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	3	2	5	1.5	CNC1CN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376794	96494	0	None	97	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	269	3	2	5	1.5	CNC1CN(c2nc(N)nc3cc(C4CC4)ccc23)C1	10.1016/j.bmcl.2013.02.091
		25147772	180188	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452847	180188	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		25147772	180188	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL452847	180188	9	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		44129131	206233	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	440	8	1	7	2.1	CCN(CC)S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL591500	206233	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	440	8	1	7	2.1	CCN(CC)S(=O)(=O)CCNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		25071319	195841	14	None	9	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL509540	195841	14	None	9	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		16082828	87035	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		CHEMBL213886	87035	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
		57398091	74883	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	3.0	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914757	74883	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	1	1	6	3.0	CN1CCN(c2nc(N)nc3c2oc2ccc(Cl)c(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		57401517	74900	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)c(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914774	74900	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	337	1	2	6	2.7	Nc1nc(N2CCNCC2)c2oc3ccc(Cl)c(Cl)c3c2n1	10.1016/j.bmcl.2011.08.014
		3035746	194959	9	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL1237146	194959	9	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/jm7014777
		CHEMBL498770	194959	9	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	414	7	2	3	3.2	N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1	10.1021/jm7014777
		136030655	63256	0	None	2	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632413	63256	0	None	2	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	1	2	3	2.2	CN1CCN(/C(=N\O)c2cc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		136192874	63257	0	None	1	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632414	63257	0	None	1	3	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	292	2	2	4	2.7	CN1CCC(/C(=N/O)c2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2010.10.041
		1204	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		1247	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		1375	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		774	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2004.08.035
		1204	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		53321919	63252	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL1632409	63252	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	322	7	3	3	3.8	N=C(NCc1ccc(Cl)cc1)SCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		10060213	109688	1	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		CHEMBL306077	109688	1	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	240	6	3	2	2.0	CC(C)/N=C(\S)NCCCCc1c[nH]cn1	10.1016/j.bmcl.2010.10.041
		155491015	183274	4	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4441731	183274	4	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		CHEMBL4596734	183274	4	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisDisplacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis	ChEMBL	207	4	2	5	0.2	CCCNC1CN(c2ccnc(N)n2)C1	10.1021/acs.jmedchem.9b01462
		44609412	96449	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	322	6	4	8	1.6	Nc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375773	96449	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	322	6	4	8	1.6	Nc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		25129523	194066	45	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm301886t
		CHEMBL492884	194066	45	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsDisplacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 mins	ChEMBL	269	2	1	5	1.5	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1	10.1021/jm301886t
		51354584	65674	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	6	1	4	2.4	c1nc(CCCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688976	65674	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	6	1	4	2.4	c1nc(CCCn2cc(CC3CCCC3)nn2)c[nH]1	10.1021/jm1013488
		76314798	112829	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	314	3	1	7	1.4	CN1CCN(c2cc(-c3ccc([N+](=O)[O-])cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		CHEMBL3133131	112829	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	314	3	1	7	1.4	CN1CCN(c2cc(-c3ccc([N+](=O)[O-])cc3)nc(N)n2)CC1	10.1039/C2MD20212C
		136042269	76689	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938978	76689	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	323	1	2	3	1.8	CN1C[C@H]2CN(C(=N)c3nc4c(F)c(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		71525678	96500	0	None	-7	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	96500	0	None	-7	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to rat histamine H4 receptorBinding affinity to rat histamine H4 receptor	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25178937	193563	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL489062	193563	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25071319	195841	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL509540	195841	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		44129209	208808	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	586	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccc(I)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL608373	208808	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	586	7	2	7	3.5	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccc(I)cc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		11013044	25682	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	333	4	1	2	3.2	O=C(c1cc2ccccc2[nH]1)N1CCN(CCc2ccccc2)CC1	10.1021/jm0341047
		CHEMBL128470	25682	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	333	4	1	2	3.2	O=C(c1cc2ccccc2[nH]1)N1CCN(CCc2ccccc2)CC1	10.1021/jm0341047
		122194625	130799	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
		CHEMBL3629828	130799	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	310	3	1	6	1.7	Cc1cccc(/C=C/c2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2015.08.014
		52952957	69937	0	None	-29	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1774594	69937	0	None	-29	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		CHEMBL1789799	69937	0	None	-29	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins by liquid scintillation counting	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
		24854703	173666	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	364	5	0	6	3.0	COc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL428606	173666	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	364	5	0	6	3.0	COc1ccc(COc2nc3ccccc3nc2N2CCN(C)CC2)cc1	10.1021/jm7014217
		CHEMBL4748908	220814	1	None	-8	12	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		156013005	184278	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	899	20	2	7	10.6	Cc1cc(OCCCNC(=O)CCCCCN2/C(=C\C=C\C=C\C3=[N+](CCCCS(=O)(=O)[O-])c4ccccc4C3(C)C)C(C)(C)c3ccccc32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		CHEMBL4639472	184278	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	899	20	2	7	10.6	Cc1cc(OCCCNC(=O)CCCCCN2/C(=C\C=C\C=C\C3=[N+](CCCCS(=O)(=O)[O-])c4ccccc4C3(C)C)C(C)(C)c3ccccc32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1021/acs.jmedchem.0c00160
		168268827	199558	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5179906	199558	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221314	199558	0	None	-6	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		52952957	69937	0	None	-29	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1774594	69937	0	None	-29	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		CHEMBL1789799	69937	0	None	-29	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunit	ChEMBL	251	8	2	3	2.4	CCC/C=C/CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2013.06.075
		25071319	195841	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		CHEMBL509540	195841	14	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1021/jm800670r
		46228101	206577	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL594022	206577	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	332	4	2	6	2.1	CN1CCN(c2cc(NCc3ccc(Cl)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL4748908	220814	1	None	-8	12	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of H4GPCRScan assay: inhibition of H4	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		46228083	206520	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	374	5	2	6	3.1	CN1CCN(c2cc(NCc3ccc(-c4ccccc4)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL593551	206520	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	374	5	2	6	3.1	CN1CCN(c2cc(NCc3ccc(-c4ccccc4)cc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		46890549	13357	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083085	13357	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	396	6	2	4	4.2	Cc1cc(OCCCN2CCCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		112936352	144272	1	None	-17	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3754008	144272	1	None	-17	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		155563489	182108	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.7	CCC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4573929	182108	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	250	3	1	6	0.7	CCC(C)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		71518865	93237	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	333	2	2	6	1.8	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(C#N)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314494	93237	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	333	2	2	6	1.8	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(C#N)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		57401167	76644	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938846	76644	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	306	1	1	3	1.5	CN1C[C@H]2CN(C(=O)c3nc4c(F)c(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		24826679	74877	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914751	74877	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	1	6	2.4	CN1CCN(c2nc(N)nc3c2oc2cccc(Cl)c23)CC1	10.1016/j.bmcl.2011.08.014
		168294161	199785	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204739	199785	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222742	199785	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		168294770	199799	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208327	199799	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222806	199799	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		44450438	102896	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc3ccccc3nc2NCc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL260371	102896	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	333	4	1	5	3.0	CN1CCN(c2nc3ccccc3nc2NCc2ccccc2)CC1	10.1021/jm7014217
		71528209	93747	0	None	-1148	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		CHEMBL2323582	93747	0	None	-1148	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		121238069	165905	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting methodDisplacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.04.033
		CHEMBL4097856	165905	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting methodDisplacement of [3H]-histamine from human histamine H4R expressed in insect Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.04.033
		24826268	74826	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	3	2	6	2.8	CCN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914544	74826	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	3	2	6	2.8	CCN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		56851443	78403	0	None	-7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	356	7	2	3	4.6	c1ccc(CN/C(=N/C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1923024	78403	0	None	-7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	356	7	2	3	4.6	c1ccc(CN/C(=N/C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		CHEMBL1963459	78403	0	None	-7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	356	7	2	3	4.6	c1ccc(CN/C(=N/C2CCCCC2)SCCCc2c[nH]cn2)cc1	10.1021/jm201042n
		121238069	165905	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		CHEMBL4097856	165905	0	None	-79	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	284	3	1	6	0.8	CN1CCN(c2nc(N)nc(Cc3ccccc3)n2)CC1	10.1016/j.ejmech.2017.09.035
		25178132	193718	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL490073	193718	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25178132	193718	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL490073	193718	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	2.9	CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		168283321	199674	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183015	199674	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222057	199674	0	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		24759622	176458	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL443764	176458	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm800876b
		24759622	176458	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm7014217
		24759622	176458	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL443764	176458	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm7014217
		CHEMBL443764	176458	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2ncc3ccccc3n2)CC1	10.1021/jm901379s
		164622259	192509	0	None	-7244	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	336	6	4	5	1.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1	10.1016/j.ejmech.2021.113190
		CHEMBL4865965	192509	0	None	-7244	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	336	6	4	5	1.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1	10.1016/j.ejmech.2021.113190
		24826167	74921	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914796	74921	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	333	2	2	6	2.9	CN[C@H]1CCN(c2nc(N)nc3c2sc2ccc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		54581938	68306	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770972	68306	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	261	3	2	5	1.1	CN[C@@H]1CCN(c2cc(N)nc(N3CCCC3)c2)C1	10.1016/j.bmcl.2011.03.017
		46890019	14084	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086085	14084	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2C3CN(C)CC32)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		24994945	116916	1	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CN[C@@H]1CCN(c2cc(C)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236567	116916	1	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	207	2	2	5	0.2	CN[C@@H]1CCN(c2cc(C)nc(N)n2)C1	10.1021/jm401727m
		1223	7740	41	None	-60	11	Human	7.1	pKi	=	7.1	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		2790	7740	41	None	-60	11	Human	7.1	pKi	=	7.1	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		CHEMBL14690	7740	41	None	-60	11	Human	7.1	pKi	=	7.1	Binding	Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayInhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assay	ChEMBL	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	10.1021/acs.jmedchem.0c00160
		51354301	65666	0	None	-10	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688969	65666	0	None	-10	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.4	c1nc(CCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		164609017	191204	0	None	-13	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4846201	191204	0	None	-13	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
		168294166	199793	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209081	199793	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222775	199793	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		168294178	199814	0	None	-5	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5205197	199814	0	None	-5	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222887	199814	0	None	-5	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		127026019	144238	0	None	-6	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	378	2	0	6	1.7	CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753705	144238	0	None	-6	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	378	2	0	6	1.7	CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		11546127	102259	2	None	-	1	Human	5.1	pKi	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		CHEMBL25725	102259	2	None	-	1	Human	5.1	pKi	=	5.1	Binding	Agonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assayAgonist activity at human H4 receptor expressed in CHO cell membranes co-expressing Galphai2 by GTPgamma[35S] binding assay	ChEMBL	414	7	2	5	3.3	COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.ejmech.2016.09.074
		10715823	12702	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	281	10	2	3	3.3	CCCCC(CC)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		CHEMBL1079747	12702	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in SF9 cells coexpressing Galphai2, Gbeta1gamma2	ChEMBL	281	10	2	3	3.3	CCCCC(CC)CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmcl.2009.10.005
		1267	10576	49	None	-33	27	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
		3035905	10576	49	None	-33	27	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
		CHEMBL260374	10576	49	None	-33	27	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1016/j.bmcl.2011.10.104
		25071319	195841	14	None	-9	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.06.123
		CHEMBL509540	195841	14	None	-9	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	295	1	2	5	1.6	Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2	10.1016/j.bmcl.2011.06.123
		25109291	198165	10	None	-501	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1016/j.bmcl.2011.06.123
		CHEMBL519240	198165	10	None	-501	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to H4R receptorBinding affinity to H4R receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1016/j.bmcl.2011.06.123
		1204	8713	119	None	-15	25	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1247	8713	119	None	-15	25	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		1375	8713	119	None	-15	25	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		774	8713	119	None	-15	25	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL90	8713	119	None	-15	25	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		DB05381	8713	119	None	-15	25	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
		10446295	8913	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2004.08.035
		1277	8913	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2004.08.035
		CHEMBL185951	8913	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	10.1016/j.bmcl.2004.08.035
		1267	10576	49	None	-21	27	Mouse	7.1	pKi	=	7.1	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		3035905	10576	49	None	-21	27	Mouse	7.1	pKi	=	7.1	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		CHEMBL260374	10576	49	None	-21	27	Mouse	7.1	pKi	=	7.1	Binding	Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsDisplacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/acs.jmedchem.0c00160
		937120	181880	8	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	244	1	0	3	1.8	CN1CCN(C(=O)c2cc3ccccc3o2)CC1	10.1016/j.bmc.2020.115924
		CHEMBL4568949	181880	8	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	244	1	0	3	1.8	CN1CCN(C(=O)c2cc3ccccc3o2)CC1	10.1016/j.bmc.2020.115924
		71681974	96424	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1cc(-c2ccccc2)nc(N)n1)c1ccnc(N)n1	10.1021/jm301886t
		CHEMBL2375749	96424	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	336	6	3	8	1.6	CN(CCNc1cc(-c2ccccc2)nc(N)n1)c1ccnc(N)n1	10.1021/jm301886t
		71681475	96430	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	317	8	5	9	1.0	CC(C)CNc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		CHEMBL2375755	96430	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	317	8	5	9	1.0	CC(C)CNc1cc(NCCNc2ccnc(N)n2)nc(N)n1	10.1021/jm301886t
		71681643	96441	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375766	96441	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	378	9	4	8	3.1	CC(C)CNc1nccc(NCCNc2cc(-c3ccccc3)nc(N)n2)n1	10.1021/jm301886t
		71681645	96443	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375768	96443	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	302	8	4	8	1.4	CC(C)CNc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		11679993	82792	0	None	-25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.0	CC(C)CNCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL205559	82792	0	None	-25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	7	2	2	2.0	CC(C)CNCCCCc1c[nH]cn1	10.1021/jm0504353
		11087453	82419	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047270	82419	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cc([N+](=O)[O-])ccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66572113	82424	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3ccc(N)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047275	82424	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3ccc(N)cc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		66573457	82438	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	2	1	2	2.4	Cc1cccc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		CHEMBL2047446	82438	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	283	2	1	2	2.4	Cc1cccc2cc(C(=O)N3CC(N4CCCC4)C3)[nH]c12	10.1016/j.ejmech.2012.06.016
		70688340	82468	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3c(F)ccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047476	82468	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	279	1	1	2	1.8	CN1CCN(C(=O)c2cc3c(F)ccc(F)c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		51354875	65682	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688986	65682	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCc2cn(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		25178937	193563	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL489062	193563	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		11846635	85455	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
		CHEMBL211242	85455	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cellsDisplacement of [3H]histamine from human histamine H4 receptor transfected in SK-N-MC cells	ChEMBL	307	0	0	4	3.4	Cc1ccc2c(c1)Oc1ccccc1C(N1CCN(C)CC1)=N2	10.1021/jm051008s
		4060730	26151	56	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		CHEMBL129199	26151	56	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysisDisplacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis	ChEMBL	243	1	1	2	1.6	CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1	10.1039/C2MD20212C
		90645159	118963	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	2.2	CN1CCN(c2nc(N)nc(-c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		CHEMBL3290586	118963	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	338	2	1	6	2.2	CN1CCN(c2nc(N)nc(-c3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2014.06.032
		162671115	189726	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	266	2	0	3	1.9	CN1CCN(CC2Cc3cc(Cl)ccc3O2)CC1	10.1016/j.bmc.2020.115924
		CHEMBL4792753	189726	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysisDisplacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis	ChEMBL	266	2	0	3	1.9	CN1CCN(CC2Cc3cc(Cl)ccc3O2)CC1	10.1016/j.bmc.2020.115924
		10197870	12073	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL106612	12073	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		91613	24759	34	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
		CHEMBL12620	24759	34	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
		71681474	96429	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	246	5	4	8	-0.0	Nc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		CHEMBL2375754	96429	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 minsDisplacement of [3H]histamine displacement from human histamine H4 receptor expressed in SK-NM-C cells after 60 mins	ChEMBL	246	5	4	8	-0.0	Nc1nccc(NCCNc2ccnc(N)n2)n1	10.1021/jm301886t
		11637064	81729	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	1	2	2.2	c1nc(CCCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		CHEMBL203228	81729	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	207	6	1	2	2.2	c1nc(CCCCCN2CCCC2)c[nH]1	10.1021/jm0504353
		11708125	83294	3	None	-251	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	5	1	2	1.3	CN(C)CCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL206000	83294	3	None	-251	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	167	5	1	2	1.3	CN(C)CCCCc1c[nH]cn1	10.1021/jm0504353
		11499376	145281	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	5	2	2	2.1	CC(C)(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		CHEMBL377491	145281	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human H4 receptor expressed in SK-N-MC cells	ChEMBL	195	5	2	2	2.1	CC(C)(C)NCCCCc1c[nH]cn1	10.1021/jm0504353
		56672434	71898	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	1	2	3.3	CN1CCC(=Cc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2011.06.123
		CHEMBL1824048	71898	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation countingDisplacement of [3H]histamine from human H4R receptor expressed in SK-N-MC cells at 10 uM after 1.5 hrs by liquid scintillation counting	ChEMBL	261	1	1	2	3.3	CN1CCC(=Cc2nc3cc(Cl)ccc3[nH]2)CC1	10.1016/j.bmcl.2011.06.123
		66572109	82416	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3c([N+](=O)[O-])cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047267	82416	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3c([N+](=O)[O-])cccc3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		10957150	82433	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		CHEMBL2047441	82433	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	288	2	1	4	1.5	CN1CCN(C(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1	10.1016/j.ejmech.2012.06.016
		3939214	133423	6	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	262	1	1	1	3.4	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCCC1	10.1016/j.bmcl.2004.08.035
		CHEMBL365257	133423	6	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranesBinding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes	ChEMBL	262	1	1	1	3.4	O=C(c1cc2cc(Cl)ccc2[nH]1)N1CCCCC1	10.1016/j.bmcl.2004.08.035
		11086114	14166	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		CHEMBL108649	14166	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1016/j.bmcl.2010.10.041
		2247	7293	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		249	7293	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		2603	7293	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		CHEMBL296419	7293	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		DB00637	7293	81	None	-117	42	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		44417471	19543	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	175	4	5	3	-0.5	N=C(N)NCCCSC(=N)N	10.1021/jm060880d
		CHEMBL1187948	19543	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	175	4	5	3	-0.5	N=C(N)NCCCSC(=N)N	10.1021/jm060880d
		CHEMBL534496	19543	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	175	4	5	3	-0.5	N=C(N)NCCCSC(=N)N	10.1021/jm060880d
		164614841	192053	0	None	-223	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	7	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		CHEMBL4858849	192053	0	None	-223	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	7	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		9923162	25712	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL128613	25712	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1007/s00044-004-0106-7
		10967174	26214	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		CHEMBL129540	26214	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at Homo sapiens (human) histamine H4 receptorAntagonist activity at Homo sapiens (human) histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1007/s00044-004-0106-7
		1204	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H4 receptor (unknown origin)Binding affinity to histamine H4 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		9923162	25712	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0341047
		CHEMBL128613	25712	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0341047
		10967174	26214	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		CHEMBL129540	26214	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- histamine from the recombinant human histamine H4 receptorDisplacement of [3H]- histamine from the recombinant human histamine H4 receptor	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0341047
		1278	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		1279	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		4908365	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		CHEMBL129198	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.125
		54580746	68165	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.1	Nc1nc(N2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770160	68165	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	248	2	2	6	0.1	Nc1nc(N2CCCC2)cc(N2CCNCC2)n1	10.1016/j.bmcl.2011.03.017
		1278	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		1279	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		4908365	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		CHEMBL129198	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.07.114
		58227157	122695	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3354815	122695	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	235	4	2	5	1.1	CN[C@@H]1CCN(c2ccnc(NC(C)C)n2)C1	10.1016/j.bmcl.2014.12.027
		58227179	123912	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393548	123912	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@H]1CCN(c2ccnc(NC3CC4CCC3C4)n2)C1	10.1016/j.bmcl.2014.12.027
		58227259	123920	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393556	123920	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	4	2	5	1.9	CN[C@@H]1CCN(c2cnnc(NC3CC4CCC3C4)c2)C1	10.1016/j.bmcl.2014.12.027
		1278	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		1279	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		4908365	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		CHEMBL129198	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.11.098
		42624150	116926	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
		CHEMBL3236577	116926	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	249	2	2	5	1.2	CN[C@@H]1CCN(c2cc(C(C)(C)C)nc(N)n2)C1	10.1021/jm401727m
		24827129	74910	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2c(Cl)cc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914785	74910	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	351	2	2	6	3.1	CN[C@@H]1CCN(c2nc(N)nc3c2oc2c(Cl)cc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		9923162	25712	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL128613	25712	6	None	199	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	321	1	1	2	2.3	CN1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)CC1	10.1021/jm0502081
		10967174	26214	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
		CHEMBL129540	26214	3	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	258	1	2	3	1.1	CN1CCN(C(=O)c2cc3cccc(N)c3[nH]2)CC1	10.1021/jm0502081
		44129212	206232	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.3	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(C(F)(F)F)cccc3n2)CC1	10.1021/jm901379s
		CHEMBL591496	206232	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	494	7	2	7	3.3	CN1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)c3c(C(F)(F)F)cccc3n2)CC1	10.1021/jm901379s
		24825522	194422	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	283	3	1	3	3.3	CC1CC(C)(C)N=C(c2cccc(Cc3c[nH]cn3)c2)O1	10.1021/jm7014149
		CHEMBL494982	194422	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells	ChEMBL	283	3	1	3	3.3	CC1CC(C)(C)N=C(c2cccc(Cc3c[nH]cn3)c2)O1	10.1021/jm7014149
		51354300	65663	0	None	15	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688946	65663	0	None	15	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	273	6	1	4	2.8	c1nc(CCCn2cc(CC3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		58227373	183287	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4455324	183287	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		CHEMBL4596881	183287	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayDisplacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay	ChEMBL	249	3	2	5	1.5	CC(C)(C)CNc1nccc(N2CC[C@@H](N)C2)n1	10.1021/acs.jmedchem.9b01342
		168294182	199827	0	None	-5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208722	199827	0	None	-5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222960	199827	0	None	-5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		46890546	13287	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1082771	13287	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	382	6	2	4	3.8	Cc1cc(OCCCN2CCC(N)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		46228069	206929	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	3	1	7	1.2	CN1CCN(c2nc(N)nc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL596348	206929	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	323	3	1	7	1.2	CN1CCN(c2nc(N)nc3c2ncn3Cc2ccccc2)CC1	10.1016/j.bmc.2009.08.059
		63868172	182835	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	222	2	1	6	-0.2	CCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		CHEMBL4590628	182835	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2	ChEMBL	222	2	1	6	-0.2	CCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.bmc.2019.02.020
		164614549	191722	0	None	-575	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4853668	191722	0	None	-575	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		164621681	192359	0	None	-64	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	444	7	4	5	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4863523	192359	0	None	-64	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	444	7	4	5	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1	10.1016/j.ejmech.2021.113190
		164627241	193208	0	None	-269	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	6	4	4	3.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4876267	193208	0	None	-269	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	6	4	4	3.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1	10.1016/j.ejmech.2021.113190
		11086114	14166	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL108649	14166	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	248	3	3	4	0.3	C/N=C(\NC#N)NC[C@H]1CC[C@@H](c2c[nH]cn2)O1	10.1021/jm0300025
		71519347	93264	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	274	4	2	6	1.2	CCCCn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		CHEMBL2314765	93264	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	274	4	2	6	1.2	CCCCn1ccc2c(N3CCNCC3)nc(N)nc21	10.1016/j.bmcl.2012.10.139
		54754351	74992	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915535	74992	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.125
		54754351	74992	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1915535	74992	0	None	10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	277	4	1	5	2.1	CN1CCN(c2cc(NCCC(C)(C)C)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		58227242	123916	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2cnnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393552	123916	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	261	3	1	5	1.6	CN1CCN(c2cnnc(NC3CCCC3)c2)CC1	10.1016/j.bmcl.2014.12.027
		121238067	173890	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2017.09.035
		CHEMBL4290148	173890	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	250	3	1	6	0.4	CC(C)Cc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2017.09.035
		57400778	74985	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915346	74985	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.07.125
		54584827	68330	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770996	68330	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	262	3	2	6	0.5	CN[C@H]1CCN(c2cc(N3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		57400778	74985	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915346	74985	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	288	1	1	3	1.3	CN1C[C@H]2CN(C(=O)c3nc4cc(F)ccc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		57400589	76683	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)cnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938972	76683	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	304	1	1	3	1.9	CN1C[C@H]2CN(C(=O)c3cc4cc(Cl)cnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		90645164	118968	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1C	10.1016/j.ejmech.2014.06.032
		CHEMBL3290591	118968	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor expressed in insect Sf9 cell membrane co-expressing Galphai2/Gbeta1gamma2 subunits after 60 mins by liquid scintillation counting analysis	ChEMBL	298	2	1	6	1.5	Cc1ccc(-c2nc(N)nc(N3CCN(C)CC3)n2)cc1C	10.1016/j.ejmech.2014.06.032
		57399016	74951	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915040	74951	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		46890548	13356	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1083084	13356	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	410	7	1	4	4.4	Cc1cc(OCCCN2CCC(N(C)C)C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		46929551	23516	0	None	-52	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2ccccn2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243335	23516	0	None	-52	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H4 receptorBinding affinity to human histamine H4 receptor	ChEMBL	337	5	1	3	5.0	CC(C)(C)c1ccc(SCC(c2ccccn2)c2c[nH]cn2)cc1	10.1021/jm100643t
		5159263	17155	11	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	259	4	3	4	0.8	Cc1cc(C)nc(N/C(N)=N/CCc2c[nH]cn2)n1	10.1021/jm7014777
		CHEMBL1162351	17155	11	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	259	4	3	4	0.8	Cc1cc(C)nc(N/C(N)=N/CCc2c[nH]cn2)n1	10.1021/jm7014777
		71525679	96501	0	None	-6	6	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	96501	0	None	-6	6	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity to mouse histamine H4 receptorBinding affinity to mouse histamine H4 receptor	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25178130	196524	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		CHEMBL515870	196524	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm800876b
		25178130	196524	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		CHEMBL515870	196524	1	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	319	3	1	5	3.1	CN1CCN(c2nc(Nc3ccccc3)c3ccccc3n2)CC1	10.1021/jm901379s
		164622153	192347	0	None	-181	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	6	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4863347	192347	0	None	-181	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	6	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1	10.1016/j.ejmech.2021.113190
		54581939	68318	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770984	68318	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	264	3	1	6	0.7	CC(C)N(C)c1nc(N)cc(N2CCN(C)CC2)n1	10.1016/j.bmcl.2011.03.017
		122193095	130692	0	None	-3	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assayDisplacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628042	130692	0	None	-3	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assayDisplacement of [3H]histamine from mouse H4 receptor expressed in HEK293 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 1 hr by liquid scintillation counting assay	ChEMBL	330	3	1	6	2.0	CN1CCN(c2nc(N)nc(/C=C/c3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2015.08.014
		58227260	123910	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393546	123910	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	287	3	1	5	1.8	CN1CCN(c2ccnc(NC3CC4CCC3C4)n2)CC1	10.1016/j.bmcl.2014.12.027
		57398176	75103	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	273	2	0	5	1.4	CN1CCN(c2cc(N3[C@@H]4CCC[C@@H]3C4)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916503	75103	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	273	2	0	5	1.4	CN1CCN(c2cc(N3[C@@H]4CCC[C@@H]3C4)ncn2)CC1	10.1016/j.bmcl.2011.07.114
		127050776	147025	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805437	147025	0	None	6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		164627189	193100	0	None	-831	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	298	6	4	4	1.0	CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4874758	193100	0	None	-831	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	298	6	4	4	1.0	CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		71519015	93243	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	246	1	2	5	0.7	CN1CCCN(c2nc(N)nc3[nH]ccc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314500	93243	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	246	1	2	5	0.7	CN1CCCN(c2nc(N)nc3[nH]ccc23)CC1	10.1016/j.bmcl.2012.10.139
		57400737	74953	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Cl)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915042	74953	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	331	1	2	6	2.6	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Cl)ccc3c2n1	10.1016/j.bmcl.2011.08.014
		57395494	74947	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915032	74947	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	349	1	2	6	2.5	Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3cccc(C(F)(F)F)c3c2n1	10.1016/j.bmcl.2011.08.014
		57395499	74956	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	2	7	1.8	C[C@H]1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CCN1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915046	74956	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	1	2	7	1.8	C[C@H]1CN(c2nc(N)nc3c2oc2ncc(Cl)cc23)CCN1	10.1016/j.bmcl.2011.08.014
		46890677	14063	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1086038	14063	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	394	6	1	4	3.8	Cc1cc(OCCCN2CC3C(C2)N3C)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		56851612	78376	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	9	2	3	5.3	CCCCN/C(=N/Cc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923032	78376	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	9	2	3	5.3	CCCCN/C(=N/Cc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963245	78376	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	398	9	2	3	5.3	CCCCN/C(=N/Cc1ccc(Cl)c(Cl)c1)SCCCc1c[nH]cn1	10.1021/jm201042n
		56851602	78378	0	None	-18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	364	9	2	3	4.7	CCCCN/C(=N/Cc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1923027	78378	0	None	-18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	364	9	2	3	4.7	CCCCN/C(=N/Cc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1021/jm201042n
		CHEMBL1963260	78378	0	None	-18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	364	9	2	3	4.7	CCCCN/C(=N/Cc1ccc(Cl)cc1)SCCCc1c[nH]cn1	10.1021/jm201042n
		25178345	180225	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccco3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452925	180225	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccco3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		51354303	65669	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.7	c1nc(CCCn2cc(C3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		CHEMBL1688971	65669	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	259	5	1	4	2.7	c1nc(CCCn2cc(C3CCCCC3)nn2)c[nH]1	10.1021/jm1013488
		25147771	181017	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL454890	181017	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		10656971	23193	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1021/jm7014217
		CHEMBL123137	23193	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	228	1	0	4	1.4	CN1CCN(c2cnc3ccccc3n2)CC1	10.1021/jm7014217
		25179123	195879	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		CHEMBL510181	195879	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm901379s
		10197870	12073	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		CHEMBL106612	12073	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Histamine H4 receptor competition binding using [3H]Na-methylhistamineHistamine H4 receptor competition binding using [3H]Na-methylhistamine	ChEMBL	167	2	2	3	0.6	NC[C@H]1CC[C@H](c2c[nH]cn2)O1	10.1021/jm0300025
		168273471	199580	0	None	-50	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173079	199580	0	None	-50	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221433	199580	0	None	-50	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysisDisplacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		57402472	74654	0	None	-1819	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910381	74654	0	None	-1819	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		44576985	17154	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	212	4	7	4	-1.3	CC(/C=C(\C)NNC(=N)N)=N/NC(=N)N	10.1021/jm7014777
		CHEMBL1162347	17154	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	212	4	7	4	-1.3	CC(/C=C(\C)NNC(=N)N)=N/NC(=N)N	10.1021/jm7014777
		71519010	93238	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	386	2	2	5	2.7	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Br)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314495	93238	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	386	2	2	5	2.7	CN1CCN(c2nc(N)nc3[nH]c(-c4ccc(Br)cc4)cc23)CC1	10.1016/j.bmcl.2012.10.139
		1204	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		1247	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		1375	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		774	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2011.10.104
		54587790	68314	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		CHEMBL1770980	68314	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human histamine H4 receptorDisplacement of [3H]histamine from human histamine H4 receptor	ChEMBL	276	4	3	6	1.2	CN[C@@H]1CCN(c2cc(NC3CCCC3)nc(N)n2)C1	10.1016/j.bmcl.2011.03.017
		54753437	74958	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL1915048	74958	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2014.12.027
		11750684	90235	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		CHEMBL219982	90235	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	426	6	1	4	4.9	Cc1ccc2[nH]c(-c3ccc(OCCCN4CCCN(C)CC4)cc3Cl)nc2c1C	10.1016/j.bmcl.2006.08.117
		54753437	74958	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1021/jm401727m
		CHEMBL1915048	74958	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1021/jm401727m
		24825794	74831	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		CHEMBL1914549	74831	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	317	1	2	6	2.5	Nc1nc(N2CCC[C@@H](N)C2)c2oc3ccc(Cl)cc3c2n1	10.1016/j.bmcl.2011.08.014
		71525679	96501	0	None	6	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	96501	0	None	6	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		25071940	194133	0	None	5	2	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		CHEMBL493281	194133	0	None	5	2	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cellsDisplacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293 cells	ChEMBL	281	1	2	5	1.2	Nc1nc2c(c(N3CCNCC3)n1)CCc1ccccc1-2	10.1021/jm800670r
		71525586	96499	0	None	22	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	2	1	6	0.9	CCc1cnc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376799	96499	0	None	22	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	272	2	1	6	0.9	CCc1cnc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		44129135	206209	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	454	6	1	8	1.1	CN1CCN(c2nc(NCCS(=O)(=O)N3CCOCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		CHEMBL591250	206209	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	454	6	1	8	1.1	CN1CCN(c2nc(NCCS(=O)(=O)N3CCOCC3)c3cc(Cl)ccc3n2)CC1	10.1021/jm901379s
		53378711	116927	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		CHEMBL3236578	116927	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis	ChEMBL	235	1	2	5	0.9	CC(C)(C)c1cc(N2CC[C@@H](N)C2)nc(N)n1	10.1021/jm401727m
		54753437	74958	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		CHEMBL1915048	74958	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptorDisplacement of [3H]histamine from recombinant human histamine H4 receptor	ChEMBL	318	2	2	7	1.8	CN[C@@H]1CCN(c2nc(N)nc3c2oc2ncc(Cl)cc23)C1	10.1016/j.bmcl.2011.08.014
		135525668	74987	0	None	263	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1915348	74987	0	None	263	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	305	1	2	3	1.7	CN1C[C@H]2CN(C(=N)c3nc4cc(F)c(F)cc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		49841611	76508	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935567	76508	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	347	2	1	5	3.2	Cc1cccc(C)c1-c1ccc2c(N3CCN(C)CC3)nc(N)nc2c1	10.1016/j.bmcl.2011.10.104
		1248	8206	28	None	-15	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		3077	8206	28	None	-15	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		90045	8206	28	None	-15	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		CHEMBL12344	8206	28	None	-15	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells	ChEMBL	161	4	2	3	0.6	CN(CCCSC(=N)N)C	10.1021/jm7014777
		11615753	79713	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3sccc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL200546	79713	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3sccc3[nH]2)CC1	10.1021/jm0502081
		10444761	130616	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3ccsc3[nH]2)CC1	10.1021/jm0502081
		CHEMBL362495	130616	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsDisplacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells	ChEMBL	249	1	1	3	1.6	CN1CCN(C(=O)c2cc3ccsc3[nH]2)CC1	10.1021/jm0502081
		16082826	87088	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@H]2C[C@@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		CHEMBL214156	87088	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine form human H4 receptorDisplacement of [3H]histamine form human H4 receptor	ChEMBL	233	5	2	2	2.7	c1nc([C@H]2C[C@@H]2CNCC2CCCCC2)c[nH]1	10.1021/jm0603318
		122193097	130694	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		CHEMBL3628044	130694	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assayDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting assay	ChEMBL	364	3	1	6	2.7	CN1CCN(c2nc(N)nc(/C=C/c3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2015.08.014
		57390344	74996	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	248	5	3	6	0.3	CNC1CN(c2cc(N)nc(NCC3CC3)n2)C1	10.1016/j.bmcl.2011.07.125
		CHEMBL1915539	74996	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsDisplacement of [3H]-histamine from full length human H4R expressed in HEK293 cells	ChEMBL	248	5	3	6	0.3	CNC1CN(c2cc(N)nc(NCC3CC3)n2)C1	10.1016/j.bmcl.2011.07.125
		49841607	76496	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		CHEMBL1935555	76496	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	257	1	1	5	1.3	Cc1cccc2c(N3CCN(C)CC3)nc(N)nc12	10.1016/j.bmcl.2011.10.104
		12686451	210828	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2cnc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		CHEMBL1743969	210828	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2cnc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		CHEMBL6992	210828	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	262	1	0	4	2.0	CN1CCN(c2cnc3cc(Cl)ccc3n2)CC1	10.1021/jm7014217
		51354010	65658	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	281	7	1	4	2.6	c1ccc(Cc2cn(CCCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		CHEMBL1688941	65658	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting	ChEMBL	281	7	1	4	2.6	c1ccc(Cc2cn(CCCCc3c[nH]cn3)nn2)cc1	10.1021/jm1013488
		127036979	144266	0	None	1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753962	144266	0	None	1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		118720434	122689	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	241	3	2	5	0.6	CN[C@@H]1CCN(c2cc(CCl)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		CHEMBL3354808	122689	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	241	3	2	5	0.6	CN[C@@H]1CCN(c2cc(CCl)nc(N)n2)C1	10.1016/j.bmcl.2014.10.013
		11212855	91005	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		CHEMBL220934	91005	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cellsDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells	ChEMBL	440	6	1	4	5.2	CN1CCN(CCCOc2ccc(-c3nc4cc(C(C)(C)C)ccc4[nH]3)c(Cl)c2)CC1	10.1016/j.bmcl.2006.08.117
		57401602	75104	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	242	1	0	4	1.3	Cc1ccc(C#N)c(N2CC3CN(C)CC3C2)n1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916504	75104	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	242	1	0	4	1.3	Cc1ccc(C#N)c(N2CC3CN(C)CC3C2)n1	10.1016/j.bmcl.2011.07.114
		156010537	185088	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	430	11	2	3	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCNCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4634235	185088	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	430	11	2	3	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCNCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		CHEMBL4651053	185088	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesDisplacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes	ChEMBL	430	11	2	3	4.3	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCNCCc1c[nH]cn1	10.1021/acs.jmedchem.0c00160
		90654503	117089	0	None	-123	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	483	9	1	4	4.9	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238447	117089	0	None	-123	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysisDisplacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting analysis	ChEMBL	483	9	1	4	4.9	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		57394626	75093	0	None	14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		CHEMBL1916494	75093	0	None	14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting techniqueDisplacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique	ChEMBL	263	5	3	5	2.1	CC(C)(C)CCNc1cc(N[C@@H]2CCNC2)ncn1	10.1016/j.bmcl.2011.07.114
		49841723	76501	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)cc1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935560	76501	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes	ChEMBL	349	3	1	6	2.6	COc1ccc(-c2cccc3c(N4CCN(C)CC4)nc(N)nc23)cc1	10.1016/j.bmcl.2011.10.104
		112936251	144044	1	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752085	144044	1	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		25178340	193564	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm800876b
		CHEMBL489069	193564	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm800876b
		25179123	195879	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		CHEMBL510181	195879	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells	ChEMBL	363	5	1	7	2.0	CCOC(=O)CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12	10.1021/jm800876b
		25178340	193564	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm901379s
		CHEMBL489069	193564	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	291	2	1	5	2.1	CNc1nc(N2CCN(C)CC2)nc2cc(Cl)ccc12	10.1021/jm901379s
		164618690	192935	0	None	-13	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	3.4	CCCCCCNC(=O)/N=C(\N)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4872375	192935	0	None	-13	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	7	4	4	3.4	CCCCCCNC(=O)/N=C(\N)Nc1cccc(-c2csc(N)n2)c1	10.1016/j.ejmech.2021.113190
		44547126	123891	1	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393527	123891	1	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	248	5	2	4	1.9	CN[C@H]1CCN(c2ccnc(NCC(C)C)c2)C1	10.1016/j.bmcl.2014.12.027
		118725540	123888	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	1.9	CN[C@@H]1CCN(c2ccnc(N3CCCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		CHEMBL3393524	123888	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	260	3	1	4	1.9	CN[C@@H]1CCN(c2ccnc(N3CCCCC3)c2)C1	10.1016/j.bmcl.2014.12.027
		46890676	14015	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	1	4	4.0	Cc1cc(OCCCN2CC3CN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		CHEMBL1085804	14015	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptorDisplacement of [3H]histamine from human recombinant histamine H4 receptor	ChEMBL	408	6	1	4	4.0	Cc1cc(OCCCN2CC3CN(C)C3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1	10.1016/j.bmcl.2010.04.017
		57393651	76682	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3cc4cccnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		CHEMBL1938971	76682	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assayDisplacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding assay	ChEMBL	270	1	1	3	1.2	CN1C[C@H]2CN(C(=O)c3cc4cccnc4[nH]3)C[C@H]2C1	10.1016/j.bmcl.2011.11.098
		24853666	162897	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	1	1	4	1.7	CN1CCCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		CHEMBL406327	162897	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsDisplacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells	ChEMBL	292	1	1	4	1.7	CN1CCCN(c2nc3cc(Cl)ccc3[nH]c2=O)CC1	10.1021/jm7014217
		112936267	144073	1	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752383	144073	1	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		127051301	146978	0	None	5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3804906	146978	0	None	5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	246	3	3	3	0.9	CN/C(=N\C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		25130914	194033	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		CHEMBL492677	194033	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2	ChEMBL	298	4	2	6	1.4	CN1CCN(c2cc(NCc3ccccc3)nc(N)n2)CC1	10.1016/j.bmc.2009.08.059
		71519178	93260	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		CHEMBL2314761	93260	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gammaDisplacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma	ChEMBL	312	2	3	5	1.9	Nc1nc(N2CC[C@H](N)C2)c2cc(-c3ccc(F)cc3)[nH]c2n1	10.1016/j.bmcl.2012.10.139
		127052293	147016	3	None	34	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	147016	3	None	34	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		1530	8963	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	8963	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	8963	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	8963	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	8963	50	None	-21379	21	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		124087	8171	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		7157	8171	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		814	8171	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		CHEMBL1172	8171	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		DB00967	8171	114	None	-5888	15	Human	8.3	pIC50	=	8.3	Binding	Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding AssayHistamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		71548412	8690	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		9879	8690	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		CHEMBL4790724	8690	20	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing mouse H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		71548412	8690	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		9879	8690	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		CHEMBL4790724	8690	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.Radioligand competitive binding assay using [<sup>3</sup>H]Histamine as tracer, and membrane preparations from CHO-K1 cells expressing human H<sub>4</sub> receptor.	Guide to Pharmacology	334	2	1	8	0.2	CNC1CN(C1)c1nc2ncc(cc2n2c1nnn2)Br	29579390
		1278	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1279	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		4908365	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		CHEMBL129198	8931	84	None	-3	8	Human	8.4	pKd	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1204	8713	119	None	-12	25	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	8713	119	None	-12	25	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	8713	119	None	-12	25	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	8713	119	None	-12	25	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	8713	119	None	-12	25	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	8713	119	None	-12	25	Rat	6.9	pKd	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1236	8848	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1237	8848	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		156615	8848	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		CHEMBL268229	8848	25	None	-204	7	Human	7.2	pKd	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1204	8713	119	None	-15	25	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	8713	119	None	-15	25	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	8713	119	None	-15	25	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	8713	119	None	-15	25	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	8713	119	None	-15	25	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	8713	119	None	-15	25	Mouse	7.4	pKd	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1241	8818	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1242	8818	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		3614	8818	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		CHEMBL507	8818	52	None	-89	5	Human	7.8	pKd	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1204	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		1204	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1204	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		1204	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1204	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1204	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1247	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		1247	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1247	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		1247	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1247	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1375	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		1375	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1375	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		1375	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1375	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		774	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		774	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		774	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		774	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		774	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		DB05381	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	10973974
		DB05381	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		DB05381	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179435
		DB05381	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		DB05381	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	8713	119	None	-3	25	Human	7.9	pKd	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		None	222920	0	3H-Histamine	4	7	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		1204	8713	119	3H-Histamine	1	25	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	1	25	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	1	25	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	1	25	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	1	25	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	1	25	Guinea pig	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		None	222920	0	3H-Histamine	4	7	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		179	7188	115	3H-Histamine	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	3H-Histamine	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	3H-Histamine	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	3H-Histamine	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	3H-Histamine	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		242	7258	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-Histamine	-7244	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		1231	7724	116	3H-Histamine	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		1231	7724	116	3H-PYRILAMINE	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		2756	7724	116	3H-Histamine	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		2756	7724	116	3H-PYRILAMINE	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		645	7724	116	3H-Histamine	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		645	7724	116	3H-PYRILAMINE	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		CHEMBL30	7724	116	3H-Histamine	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		CHEMBL30	7724	116	3H-PYRILAMINE	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		DB00501	7724	116	3H-Histamine	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		DB00501	7724	116	3H-PYRILAMINE	-177	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		277	8083	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-Histamine	-301	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1248	8206	28	3H-PYRILAMINE	-15	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		3077	8206	28	3H-PYRILAMINE	-15	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		90045	8206	28	3H-PYRILAMINE	-15	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		CHEMBL12344	8206	28	3H-PYRILAMINE	-15	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		1224	8214	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	8214	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	8214	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	8214	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	8214	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	8214	83	3H-Histamine	-194	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1212	8443	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-Histamine	-19952	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1353	8692	93	3H-Histamine	-6918	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-Histamine	-6918	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-Histamine	-6918	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-Histamine	-6918	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-Histamine	-6918	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	9688	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-Histamine	-5128	65	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		119570	9933	96	3H-Histamine	-181	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-Histamine	-181	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-Histamine	-181	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-Histamine	-181	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-Histamine	-181	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2337	10030	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-Histamine	-1122	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1234	10064	68	3H-Histamine	-190	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		3001055	10064	68	3H-Histamine	-190	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		CHEMBL512	10064	68	3H-Histamine	-190	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		DB00863	10064	68	3H-Histamine	-190	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		2389	10104	118	3H-Histamine	-26915	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-Histamine	-26915	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-Histamine	-26915	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-Histamine	-26915	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-Histamine	-26915	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6917970	10463	61	3H-Histamine	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	10463	61	3H-Histamine	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	10463	61	3H-Histamine	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		213	10625	55	3H-Histamine	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	3H-Histamine	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	3H-Histamine	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	3H-Histamine	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	3H-Histamine	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		185	10778	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	10778	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	10778	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	10778	60	3H-Histamine	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		2865	10915	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-Histamine	-20417	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		10297	33885	30	3H-Histamine	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	33885	30	3H-Histamine	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	53574	99	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	53574	99	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	53574	99	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		10624	77075	19	3H-Histamine	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	77075	19	3H-Histamine	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	77075	19	3H-Histamine	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		21830793	98610	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	98610	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		46780481	114308	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-Histamine	-58884	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		446220	140299	14	3H-Histamine	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	140299	14	3H-Histamine	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		4495	203314	92	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	203314	92	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	207330	115	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	207330	115	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	207330	115	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	209053	22	3H-Histamine	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-Histamine	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-Histamine	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4054	212280	72	3H-Histamine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	212280	72	3H-Histamine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	212280	72	3H-Histamine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		11954259	222758	0	3H-Histamine	-33113	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		None	222772	0	3H-Histamine	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	222798	0	3H-Histamine	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	222920	0	3H-PYRILAMINE	-7585	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		25137849	222958	0	3H-Histamine	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	222958	0	3H-Histamine	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	223090	0	3H-Histamine	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	223091	0	3H-Histamine	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	223092	0	3H-Histamine	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	223093	0	3H-Histamine	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	223094	0	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	223095	0	3H-Histamine	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	223096	0	3H-Histamine	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	223104	0	3H-Histamine	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	223105	0	3H-Histamine	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		135269	223168	0	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	223169	0	3H-Histamine	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		123619	223172	0	3H-Histamine	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	223173	0	3H-Histamine	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	223174	0	3H-Histamine	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	223268	0	3H-Histamine	-4570	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		135409468	8816	69	3H-Histamine	-363	39	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	8816	69	3H-Histamine	-363	39	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	8816	69	3H-Histamine	-363	39	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		1204	8713	119	3H-Histamine	1	25	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	1	25	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	1	25	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	1	25	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	1	25	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	1	25	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1225	8253	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	8253	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	8253	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	8253	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	8253	26	3H-PYRILAMINE	-371	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		1226	8800	20	3H-Histamine	2	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		41376	8800	20	3H-Histamine	2	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		CHEMBL12608	8800	20	3H-Histamine	2	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		1223	7740	41	3H-JNJ 7777120	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	3H-JNJ 7777120	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	3H-JNJ 7777120	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1251	8795	39	3H-JNJ 7777120	-100	5	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	8795	39	3H-JNJ 7777120	-100	5	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	8795	39	3H-JNJ 7777120	-100	5	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		1253	8839	7	3H-N-alpha-methylhistamine	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	None
		132937	8839	7	3H-N-alpha-methylhistamine	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	None
		CHEMBL19010	8839	7	3H-N-alpha-methylhistamine	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	342	6	1	2	3.2	Ic1ccc(cc1)COCCCc1cnc[nH]1	None
		None	223033	0	3H-Histamine	-13	20	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		None	223033	0	3H-N-alpha-methylhistamine	-13	20	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		1223	7740	41	3H-Histamine	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	3H-Histamine	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	3H-Histamine	-60	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1267	10576	49	3H-Histamine	-33	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	10576	49	3H-N-alpha-methylhistamine	-33	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-Histamine	-33	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-N-alpha-methylhistamine	-33	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-Histamine	-33	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-N-alpha-methylhistamine	-33	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1547484	7727	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	7727	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	7727	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	7727	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	7727	74	3H-PYRILAMINE	-5	20	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		45037031	222935	0	3H-Histamine	-70	4	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	285	2	2	2	1.5	C[C@H](CC1=CN=CN1)N.Br.Br	None
		1223	7740	41	125I-iodophenpropit	-60	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	125I-iodophenpropit	-60	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	125I-iodophenpropit	-60	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1204	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	8713	119	3H-N-alpha-methylhistamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-N-alpha-methylhistamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-N-alpha-methylhistamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-N-alpha-methylhistamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-N-alpha-methylhistamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-N-alpha-methylhistamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		2286	9957	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	3H-PYRILAMINE	-10	30	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		1204	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	-3	25	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		3032915	22267	24	3H-Histamine	-1	7	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	22267	24	3H-Histamine	-1	7	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		1204	8713	119	3H-JNJ 7777120	-3	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-JNJ 7777120	-3	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-JNJ 7777120	-3	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-JNJ 7777120	-3	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-JNJ 7777120	-3	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-JNJ 7777120	-3	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1251	8795	39	125I-iodophenpropit	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		1251	8795	39	3H-Histamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		1251	8795	39	3H-N-alpha-methylhistamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	8795	39	125I-iodophenpropit	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	8795	39	3H-Histamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	8795	39	3H-N-alpha-methylhistamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	8795	39	125I-iodophenpropit	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	8795	39	3H-Histamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	8795	39	3H-N-alpha-methylhistamine	-100	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		None	223033	0	125I-iodophenpropit	-13	20	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		None	223033	0	3H-JNJ 7777120	-13	20	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		103	10925	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-Histamine	-89	53	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	7745	93	3H-Histamine	-57	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-Histamine	-57	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-Histamine	-57	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-Histamine	-57	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-Histamine	-57	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1204	8713	119	3H-Histamine	-3	25	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	-3	25	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	-3	25	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	-3	25	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	-3	25	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	-3	25	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		11957573	8791	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		1250	8791	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		3692	8791	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		CHEMBL19439	8791	34	3H-Histamine	-40	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		277	8083	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-PYRILAMINE	-301	50	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1241	8818	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		1242	8818	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		3614	8818	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		CHEMBL507	8818	52	3H-Histamine	-89	5	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	125	2	1	3	-0.1	Cn1cc(nc1)CCN	None
		None	222920	0	3H-Histamine	-7585	7	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		100	10577	58	3H-Histamine	-56	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-Histamine	-56	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-Histamine	-56	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-Histamine	-56	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-Histamine	-56	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1204	8713	119	125I-iodophenpropit	-3	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	125I-iodophenpropit	-3	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	125I-iodophenpropit	-3	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	125I-iodophenpropit	-3	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	125I-iodophenpropit	-3	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	125I-iodophenpropit	-3	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1226	8800	20	3H-N-alpha-methylhistamine	2	7	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		41376	8800	20	3H-N-alpha-methylhistamine	2	7	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		CHEMBL12608	8800	20	3H-N-alpha-methylhistamine	2	7	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	None
		45037031	222935	0	3H-N-alpha-methylhistamine	-70	4	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	285	2	2	2	1.5	C[C@H](CC1=CN=CN1)N.Br.Br	None
		1267	10576	49	3H-Histamine	-33	27	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-Histamine	-33	27	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-Histamine	-33	27	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1210	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	7705	51	3H-PYRILAMINE	-295	21	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		135398737	7745	93	125I-iodophenpropit	-57	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	125I-iodophenpropit	-57	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	125I-iodophenpropit	-57	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	125I-iodophenpropit	-57	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	125I-iodophenpropit	-57	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1239	8814	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		1240	8814	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		912	8814	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		CHEMBL268490	8814	24	3H-N-alpha-methylhistamine	-154	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	3	2	2	0.2	CNCCc1cnc[nH]1	None
		180	7189	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	3H-PYRILAMINE	-32	40	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1204	8713	119	3H-PYRILAMINE	-3	25	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-PYRILAMINE	-3	25	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-PYRILAMINE	-3	25	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-PYRILAMINE	-3	25	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-PYRILAMINE	-3	25	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-PYRILAMINE	-3	25	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		None	222920	0	3H-Histamine	-7585	7	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		1248	8206	28	3H-Histamine	-15	7	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		3077	8206	28	3H-Histamine	-15	7	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		90045	8206	28	3H-Histamine	-15	7	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		CHEMBL12344	8206	28	3H-Histamine	-15	7	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		11957573	8791	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		1250	8791	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		3692	8791	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		CHEMBL19439	8791	34	3H-PYRILAMINE	-40	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		921599	26227	51	3H-Histamine	234	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	None
		CHEMBL129660	26227	51	3H-Histamine	234	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	2	1.2	O=C(c1cc2ccccc2[nH]1)N1CCNCC1	None
		1204	8713	119	3H-Histamine	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1267	10576	49	125I-iodophenpropit	-33	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	125I-iodophenpropit	-33	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	125I-iodophenpropit	-33	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3032915	22267	24	3H-Histamine	-1	7	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		3032915	22267	24	3H-N-alpha-methylhistamine	-1	7	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	22267	24	3H-Histamine	-1	7	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	22267	24	3H-N-alpha-methylhistamine	-1	7	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		135398737	7745	93	3H-JNJ 7777120	-57	90	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-JNJ 7777120	-57	90	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-JNJ 7777120	-57	90	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-JNJ 7777120	-57	90	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-JNJ 7777120	-57	90	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		45073439	222936	0	3H-N-alpha-methylhistamine	-75	4	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	285	2	2	2	1.5	C[C@@H](CC1=CN=CN1)N.Br.Br	None
		1224	8214	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	8214	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	8214	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	8214	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	8214	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	8214	83	None	-194	13	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		2782	38774	67	3H-PYRILAMINE	-	1	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL1407943	38774	67	3H-PYRILAMINE	-	1	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL3216363	38774	67	3H-PYRILAMINE	-	1	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		1223	7740	41	3H-Histamine	-60	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	3H-Histamine	-60	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	3H-Histamine	-60	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		4761	20213	42	3H-PYRILAMINE	-	1	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1193	20213	42	3H-PYRILAMINE	-	1	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1580221	20213	42	3H-PYRILAMINE	-	1	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		1267	10576	49	3H-Histamine	-33	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-Histamine	-33	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-Histamine	-33	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	10576	49	3H-Histamine	-33	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-Histamine	-33	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-Histamine	-33	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		115237	62359	119	None	-891	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	None	-891	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2247	7293	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	7293	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	7293	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	7293	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	7293	81	None	-117	42	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation countingDisplacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		5625	206447	72	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	None
		CHEMBL593	206447	72	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	None
		1613	9127	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	None	-134	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		16106	124924	34	None	-20	11	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
		CHEMBL340801	124924	34	None	-20	11	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
		4761	20213	42	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1193	20213	42	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		CHEMBL1580221	20213	42	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	None
		135398737	7745	93	None	-54	90	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-54	90	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-54	90	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-54	90	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-54	90	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	10577	58	None	-56	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	None	-56	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	None	-56	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	None	-56	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	None	-56	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		16362	9899	71	None	-562	29	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	None	-562	29	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	None	-562	29	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	None	-562	29	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	None	-562	29	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at H4 receptor (unknown origin)Antagonist activity at H4 receptor (unknown origin)	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		135398737	7745	93	None	-44	90	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-44	90	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-44	90	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-44	90	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-44	90	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		103	10925	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	None	-89	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	7706	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-PYRILAMINE	-70	72	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	7706	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-Histamine	-70	72	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1613	9127	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-Histamine	-134	44	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398737	7745	93	3H-Histamine	-57	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-Histamine	-57	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-Histamine	-57	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-Histamine	-57	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-Histamine	-57	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11957573	8791	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		1250	8791	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		3692	8791	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		CHEMBL19439	8791	34	3H-N-alpha-methylhistamine	-40	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	None
		2782	38774	67	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL1407943	38774	67	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		CHEMBL3216363	38774	67	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	None
		1210	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	7705	51	None	-295	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2286	9957	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	None	-10	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2726	7706	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-70	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1204	8713	119	None	-15	25	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	None	-15	25	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	None	-15	25	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	None	-15	25	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	None	-15	25	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	None	-15	25	Mouse	8.2	pKi	=	8.2	Binding	Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	8713	119	None	-12	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	None	-12	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	None	-12	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	None	-12	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	None	-12	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	None	-12	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayBinding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1223	7740	41	3H-Histamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		1223	7740	41	3H-N-alpha-methylhistamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	3H-Histamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	3H-N-alpha-methylhistamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	3H-Histamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	3H-N-alpha-methylhistamine	-60	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		135	9310	43	3H-PYRILAMINE	-389	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-PYRILAMINE	-389	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-PYRILAMINE	-389	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-PYRILAMINE	-389	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-PYRILAMINE	-389	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1267	10576	49	3H-JNJ 7777120	-33	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	10576	49	3H-JNJ-5207852	-33	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-JNJ 7777120	-33	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-JNJ-5207852	-33	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-JNJ 7777120	-33	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-JNJ-5207852	-33	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1204	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	8713	119	3H-Histamine	-3	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-Histamine	-3	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-Histamine	-3	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-Histamine	-3	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-Histamine	-3	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-Histamine	-3	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		180	7189	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	None	-32	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		277	8083	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	None	-301	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1204	8713	119	None	1	25	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	None	1	25	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	None	1	25	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	None	1	25	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	None	1	25	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	None	1	25	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		135398737	7745	93	None	-57	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-57	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-57	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-57	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-57	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-Histamine	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-Histamine	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-Histamine	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-Histamine	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-Histamine	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-PYRILAMINE	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-PYRILAMINE	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-PYRILAMINE	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-PYRILAMINE	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-PYRILAMINE	-57	90	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		115237	62359	119	3H-Histamine	-891	54	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-Histamine	-891	54	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1251	8795	39	3H-Histamine	-100	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		3035842	8795	39	3H-Histamine	-100	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		CHEMBL18661	8795	39	3H-Histamine	-100	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	None
		23650961	10618	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		9276	10618	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		CHEMBL3301609	10618	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		DB12522	10618	26	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacament of histamine from human H4 recepotor expressed in mammalian cells.Displacament of histamine from human H4 recepotor expressed in mammalian cells.	Guide to Pharmacology	392	6	2	5	4.5	CN1CCC(CC1)CCCNc1ncc(c(n1)C)c1nc2c([nH]1)cc(cc2C)C	None
		1265	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	12606603
		1265	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	15294456
		1265	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		6422124	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	12606603
		6422124	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	15294456
		6422124	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		CHEMBL14638	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	12606603
		CHEMBL14638	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	15294456
		CHEMBL14638	7729	60	None	-2290	8	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		1267	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179434
		1267	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179436
		1267	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11181941
		1267	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		1267	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	12606603
		1267	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	15294456
		3035905	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179434
		3035905	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179436
		3035905	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11181941
		3035905	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		3035905	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	12606603
		3035905	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	15294456
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179434
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11179436
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11181941
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	12606603
		CHEMBL260374	10576	49	None	-33	27	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	15294456
		10446295	8913	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	15454206
		1277	8913	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	15454206
		CHEMBL185951	8913	34	None	269	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	1	1	3	1.6	CN1CCN(CC1)C(=O)c1nc2c([nH]1)cc(cc2)Cl	15454206
		1223	7740	41	None	-338	11	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		2790	7740	41	None	-338	11	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		CHEMBL14690	7740	41	None	-338	11	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		1274	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	17154494
		3063228	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	17154494
		CHEMBL1196470	10836	16	None	19	2	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	4	3	-1.1	NC(=N)SCCN=C(N)N	17154494
		1269	6909	41	None	213	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	15947036
		1269	6909	41	None	213	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	16432504
		37463	6909	41	None	213	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	15947036
		37463	6909	41	None	213	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	16432504
		CHEMBL275443	6909	41	None	213	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	15947036
		CHEMBL275443	6909	41	None	213	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	16432504
		1223	7740	41	None	-363	11	Mouse	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		2790	7740	41	None	-363	11	Mouse	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		CHEMBL14690	7740	41	None	-363	11	Mouse	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		1223	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11179434
		1223	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11181941
		1223	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		1223	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		1223	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	15947036
		2790	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11179434
		2790	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11181941
		2790	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		2790	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		2790	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	15947036
		CHEMBL14690	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11179434
		CHEMBL14690	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11181941
		CHEMBL14690	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	11561071
		CHEMBL14690	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		CHEMBL14690	7740	41	None	-60	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	15947036
		24994634	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	24495018
		24994634	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		8984	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	24495018
		8984	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	24495018
		CHEMBL3236549	8923	31	None	-2	7	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		45257132	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		8983	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		CHEMBL595180	10454	10	None	42	4	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		1278	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1278	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		1278	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		1279	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		1279	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		1279	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		4908365	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		4908365	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		4908365	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		CHEMBL129198	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	14722321
		CHEMBL129198	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	15947036
		CHEMBL129198	8931	84	None	-3	8	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	16854056
		117072554	8804	0	None	81	4	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	5	2	6	2.3	CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1	26084539
		8982	8804	0	None	81	4	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	5	2	6	2.3	CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1	26084539
		24745335	7083	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		8985	7083	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		CHEMBL1915540	7083	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		DB15027	7083	12	None	4	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	6	0.7	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N	26084539
		5048	9907	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		8924	9907	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		9948102	9907	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		CHEMBL462605	9907	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		DB11642	9907	64	None	-48977	7	Human	4.0	pKi	>	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		441082	7946	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		8981	7946	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		CHEMBL191703	7946	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		11697697	9325	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		7346	9325	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		CHEMBL476323	9325	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		DB11910	9325	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		1547484	7727	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	7727	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	7727	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	7727	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	7727	74	None	-5	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		10058807	8799	2	None	-1	2	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	4	3	3	-0.0	CN=C(NC#N)NCCCc1cnc[nH]1	11179436
		1276	8799	2	None	-1	2	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	4	3	3	-0.0	CN=C(NC#N)NCCCc1cnc[nH]1	11179436
		CHEMBL2261340	8799	2	None	-1	2	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	4	3	3	-0.0	CN=C(NC#N)NCCCc1cnc[nH]1	11179436
		135398737	7745	93	None	-54	90	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		38	7745	93	None	-54	90	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		722	7745	93	None	-54	90	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		CHEMBL42	7745	93	None	-54	90	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		DB00363	7745	93	None	-54	90	Mouse	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		1238	8863	13	None	-19	3	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	11181941
		6603865	8863	13	None	-19	3	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	11181941
		CHEMBL11919	8863	13	None	-19	3	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@@H](Cc1cnc[nH]1)N	11181941
		1248	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		1248	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		1248	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		1248	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		3077	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		3077	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		3077	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		3077	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		90045	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		90045	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		90045	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		90045	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		CHEMBL12344	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179434
		CHEMBL12344	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11179436
		CHEMBL12344	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	11181941
		CHEMBL12344	8206	28	None	-15	7	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	4	2	3	0.6	CN(CCCSC(=N)N)C	15947036
		135398737	7745	93	None	-44	90	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		38	7745	93	None	-44	90	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		722	7745	93	None	-44	90	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		CHEMBL42	7745	93	None	-44	90	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		DB00363	7745	93	None	-44	90	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		11313837	9278	8	None	-1995	2	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	15771452
		1254	9278	8	None	-1995	2	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	15771452
		CHEMBL175782	9278	8	None	-1995	2	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	1	2	1.3	CN1CCC(CC1)Cc1[nH]cnc1	15771452
		124846	8727	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	10	3	3	4.1	CC(NCCc1cnc[nH]1)CCCCC(=O)Nc1ccc(cc1)C(F)(F)F	11179436
		1273	8727	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	10	3	3	4.1	CC(NCCc1cnc[nH]1)CCCCC(=O)Nc1ccc(cc1)C(F)(F)F	11179436
		CHEMBL67601	8727	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	10	3	3	4.1	CC(NCCc1cnc[nH]1)CCCCC(=O)Nc1ccc(cc1)C(F)(F)F	11179436
		12656	8821	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	2	0.5	CN(CCc1[nH]cnc1)C	16432504
		1270	8821	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	2	0.5	CN(CCc1[nH]cnc1)C	16432504
		CHEMBL12704	8821	0	None	-	1	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	2	0.5	CN(CCc1[nH]cnc1)C	16432504
		1194	6834	3	None	-1318	4	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	15947036
		23786499	6834	3	None	-1318	4	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	15947036
		CHEMBL26116	6834	3	None	-1318	4	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	15947036
		1229	7530	0	None	-19	6	Rat	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		5311293	7530	0	None	-19	6	Rat	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		1229	7530	0	None	-15	6	Mouse	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		5311293	7530	0	None	-15	6	Mouse	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		1236	8848	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1237	8848	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		156615	8848	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		CHEMBL268229	8848	25	None	-851	7	Rat	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1241	8818	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1242	8818	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		3614	8818	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		CHEMBL507	8818	52	None	-407	5	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1268	6870	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	15947036
		1268	6870	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	16432504
		92613	6870	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	15947036
		92613	6870	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	4	3	5	-2.0	OCCN1CN(CO)C(=S)N(C1)CO	16432504
		1236	8848	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1237	8848	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		156615	8848	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		CHEMBL268229	8848	25	None	-537	7	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		135398737	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		135398737	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		135398737	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		135398737	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		38	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		38	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		38	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		38	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		722	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		722	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		722	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		722	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		CHEMBL42	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		CHEMBL42	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		CHEMBL42	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		CHEMBL42	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		DB00363	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179434
		DB00363	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11179436
		DB00363	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11561071
		DB00363	7745	93	None	-57	90	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15947036
		1241	8818	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1242	8818	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		3614	8818	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		CHEMBL507	8818	52	None	-257	5	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1236	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1236	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		1236	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		1236	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1237	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		1237	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		1237	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		1237	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		156615	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		156615	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		156615	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		156615	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		CHEMBL268229	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179434
		CHEMBL268229	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11179436
		CHEMBL268229	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11181941
		CHEMBL268229	8848	25	None	-204	7	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	2	2	0.3	C[C@H](Cc1cnc[nH]1)N	11561071
		1271	8817	0	None	-	1	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	3	0.4	NCCc1ncn(c1)CC	16432504
		44292270	8817	0	None	-	1	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	3	0.4	NCCc1ncn(c1)CC	16432504
		CHEMBL46296	8817	0	None	-	1	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	139	3	1	3	0.4	NCCc1ncn(c1)CC	16432504
		1239	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		1239	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		1240	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		1240	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		912	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		912	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		CHEMBL268490	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11179436
		CHEMBL268490	8814	24	None	-154	5	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	3	2	2	0.2	CNCCc1cnc[nH]1	11181941
		1229	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179434
		1229	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179436
		1229	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11181941
		1229	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		1229	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	15947036
		5311293	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179434
		5311293	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11179436
		5311293	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11181941
		5311293	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	11561071
		5311293	7530	0	None	-1	6	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	5	3	2	2.0	CNC(=S)NCCCCc1cccc2c1cn[nH]2	15947036
		1204	8713	119	None	-12	25	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	8713	119	None	-12	25	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	8713	119	None	-12	25	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	8713	119	None	-12	25	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	8713	119	None	-12	25	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	8713	119	None	-12	25	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1204	8713	119	None	-15	25	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	8713	119	None	-15	25	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	8713	119	None	-15	25	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	8713	119	None	-15	25	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	8713	119	None	-15	25	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	8713	119	None	-15	25	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1241	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1241	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1241	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		1242	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		1242	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		1242	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		3614	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		3614	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		3614	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		CHEMBL507	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11179434
		CHEMBL507	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	11561071
		CHEMBL507	8818	52	None	-89	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	125	2	1	3	-0.1	Cn1cc(nc1)CCN	16432504
		1267	10576	49	None	-21	27	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		1267	10576	49	None	-14	27	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		3035905	10576	49	None	-21	27	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		3035905	10576	49	None	-14	27	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		CHEMBL260374	10576	49	None	-21	27	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		CHEMBL260374	10576	49	None	-14	27	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	11561071
		1266	8838	0	None	-23	3	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	9	3	4	2.8	N[C@H](SCCCc1cnc[nH]1)NCCc1ccc(cc1)I	11179436
		3960	8838	0	None	-23	3	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	9	3	4	2.8	N[C@H](SCCCc1cnc[nH]1)NCCc1ccc(cc1)I	11179436
		5311186	8838	0	None	-23	3	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	9	3	4	2.8	N[C@H](SCCCc1cnc[nH]1)NCCc1ccc(cc1)I	11179436
		1226	8800	20	None	2	7	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	11179434
		1226	8800	20	None	2	7	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	15947036
		41376	8800	20	None	2	7	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	11179434
		41376	8800	20	None	2	7	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	15947036
		CHEMBL12608	8800	20	None	2	7	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	11179434
		CHEMBL12608	8800	20	None	2	7	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	15947036
		1251	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179434
		1251	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179436
		1251	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	14640553
		3035842	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179434
		3035842	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179436
		3035842	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	14640553
		CHEMBL18661	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179434
		CHEMBL18661	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	11179436
		CHEMBL18661	8795	39	None	-100	5	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	165	2	2	2	1.0	N1CCC(CC1)Cc1[nH]cnc1	14640553
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		1204	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		1247	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		1375	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		774	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		CHEMBL90	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179434
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11179436
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11181941
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	11561071
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15454206
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15947036
		DB05381	8713	119	None	-3	25	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16432504
		11957573	8791	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		11957573	8791	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		1250	8791	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		1250	8791	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		3692	8791	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		3692	8791	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		CHEMBL19439	8791	34	None	-27	6	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		CHEMBL19439	8791	34	None	-27	6	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		11957573	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		11957573	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		11957573	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		11957573	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		1250	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		1250	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		1250	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		1250	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		3692	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		3692	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		3692	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		3692	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071
		CHEMBL19439	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179434
		CHEMBL19439	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11179436
		CHEMBL19439	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11181941
		CHEMBL19439	8791	34	None	-40	6	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	170	3	3	3	0.6	NC(=N)SCCc1cnc[nH]1	11561071

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Ligand source activities (1 row/activity)