Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 16133225 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 172198 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 2504 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 45266664 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 5272 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| CHEMBL408403 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| DB11842 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 16133225 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 172198 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 2504 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 45266664 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 5272 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| CHEMBL408403 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| DB11842 | 7207 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 127030943 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787243 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787375 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787700 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 127030943 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787243 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787375 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787700 | 145973 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 16133225 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 172198 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 2504 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 45266664 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 5272 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL408403 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| DB11842 | 7207 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 127029976 | 145995 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786145 | 145995 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787767 | 145995 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127029976 | 145995 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786145 | 145995 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787767 | 145995 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 155564502 | 182039 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4572408 | 182039 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 11943 | 10647 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 145925549 | 10647 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL4438122 | 10647 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155558059 | 181462 | 0 | None | -5 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4559239 | 181462 | 0 | None | -5 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| 155541440 | 179798 | 0 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| CHEMBL4518530 | 179798 | 0 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| 155541295 | 179790 | 0 | None | 4 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4518318 | 179790 | 0 | None | 4 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 155540639 | 179712 | 0 | None | -1 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4516768 | 179712 | 0 | None | -1 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL2028943 | 215914 | 0 | None | -1 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||||
| 155553930 | 182220 | 0 | None | -1 | 2 | Rat | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4576650 | 182220 | 0 | None | -1 | 2 | Rat | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155540033 | 179669 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| CHEMBL4515768 | 179669 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| 127029977 | 145996 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786986 | 145996 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787768 | 145996 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127029977 | 145996 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786986 | 145996 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787768 | 145996 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127031545 | 145974 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787379 | 145974 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787701 | 145974 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 127031545 | 145974 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787379 | 145974 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787701 | 145974 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 16133225 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 172198 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 2504 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 45266664 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 5272 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL408403 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| DB11842 | 7207 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155541440 | 179798 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| CHEMBL4518530 | 179798 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| 10533900 | 182748 | 8 | None | 10 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL4588454 | 182748 | 8 | None | 10 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| 155556507 | 181265 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4554466 | 181265 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155563538 | 182079 | 0 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | ||
| CHEMBL4573250 | 182079 | 0 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | ||
| 155559104 | 181585 | 0 | None | 2 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| CHEMBL4562270 | 181585 | 0 | None | 2 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| 155554865 | 181133 | 0 | None | 2 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4551317 | 181133 | 0 | None | 2 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 155540328 | 179680 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| CHEMBL4516066 | 179680 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| 155553479 | 180957 | 0 | None | 3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4547423 | 180957 | 0 | None | 3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 155558003 | 181472 | 0 | None | 1 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4559421 | 181472 | 0 | None | 1 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155547428 | 180394 | 0 | None | -22 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4533618 | 180394 | 0 | None | -22 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155566196 | 182525 | 0 | None | -5 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4583284 | 182525 | 0 | None | -5 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155558428 | 181508 | 0 | None | 1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| CHEMBL4560224 | 181508 | 0 | None | 1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| 11944 | 10648 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155552190 | 10648 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL4544228 | 10648 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL77838 | 222657 | 5 | None | -1 | 2 | Rat | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | ||||
| 155552475 | 180831 | 0 | None | 9 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 180831 | 0 | None | 9 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155542907 | 179956 | 0 | None | 3 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | ||
| CHEMBL4522038 | 179956 | 0 | None | 3 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | ||
| CHEMBL2028943 | 215914 | 0 | None | 1 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||||
| 155552475 | 180831 | 0 | None | -9 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 180831 | 0 | None | -9 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155556530 | 181290 | 0 | None | 2 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4555119 | 181290 | 0 | None | 2 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | ||
| 155561376 | 182454 | 0 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | ||
| CHEMBL4581718 | 182454 | 0 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | ||
| 155541125 | 179744 | 0 | None | 6 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | ||
| CHEMBL4517561 | 179744 | 0 | None | 6 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | ||
| 24892627 | 62427 | 5 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| CHEMBL1460676 | 62427 | 5 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| CHEMBL1621632 | 62427 | 5 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| 155558059 | 181462 | 0 | None | 5 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4559239 | 181462 | 0 | None | 5 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL938 | 222686 | 28 | None | -10 | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | ||||
| CHEMBL312754 | 217889 | 18 | None | 1 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||||
| 154573825 | 182768 | 9 | None | 8 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4588946 | 182768 | 9 | None | 8 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| 155560463 | 181819 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | ||
| CHEMBL4567667 | 181819 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | ||
| 155553003 | 180855 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL4544308 | 180855 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| 10533900 | 182748 | 8 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL4588454 | 182748 | 8 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL2392353 | 217193 | 6 | None | -50 | 3 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155553098 | 180889 | 0 | None | 22 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4545153 | 180889 | 0 | None | 22 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 1588251 | 66051 | 10 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 436 | 4 | 0 | 5 | 5.8 | CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O | nan | ||
| CHEMBL1704271 | 66051 | 10 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 436 | 4 | 0 | 5 | 5.8 | CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O | nan | ||
| 155540328 | 179680 | 0 | None | 3 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| CHEMBL4516066 | 179680 | 0 | None | 3 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| 155540033 | 179669 | 0 | None | 2 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| CHEMBL4515768 | 179669 | 0 | None | 2 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| 155539838 | 179674 | 0 | None | 1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4515848 | 179674 | 0 | None | 1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL2370909 | 216727 | 0 | None | 7 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||||
| 155558784 | 181555 | 0 | None | -2 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4561366 | 181555 | 0 | None | -2 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 154573825 | 182768 | 9 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4588946 | 182768 | 9 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| 155553003 | 180855 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL4544308 | 180855 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| 3025727 | 190859 | 10 | None | 10000 | 2 | Rabbit | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL48242 | 190859 | 10 | None | 10000 | 2 | Rabbit | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971704 | 119162 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329616 | 119162 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 133031 | 107636 | 21 | None | 1 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
| CHEMBL293511 | 107636 | 21 | None | 1 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
| 9892554 | 106970 | 6 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 510 | 9 | 1 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL288246 | 106970 | 6 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 510 | 9 | 1 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971715 | 175015 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 492 | 10 | 2 | 6 | 5.4 | CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL433646 | 175015 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 492 | 10 | 2 | 6 | 5.4 | CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971716 | 21296 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 506 | 11 | 2 | 6 | 5.6 | CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120199 | 21296 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 506 | 11 | 2 | 6 | 5.6 | CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971706 | 213988 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92654 | 213988 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 183134 | 211623 | 17 | None | -4 | 7 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm1013693 | ||
| CHEMBL7550 | 211623 | 17 | None | -4 | 7 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm1013693 | ||
| 14971698 | 214072 | 0 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93226 | 214072 | 0 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9827346 | 106513 | 4 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL284918 | 106513 | 4 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL34866 | 106513 | 4 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| 9870652 | 77667 | 75 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951143 | 77667 | 75 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971720 | 121600 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL334145 | 121600 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971720 | 121600 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334145 | 121600 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971705 | 213528 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 492 | 9 | 2 | 6 | 5.7 | CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL90011 | 213528 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 492 | 9 | 2 | 6 | 5.7 | CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10325927 | 213665 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 7.3 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL90774 | 213665 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 7.3 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971714 | 105966 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 484 | 9 | 2 | 6 | 4.9 | CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL281386 | 105966 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 484 | 9 | 2 | 6 | 4.9 | CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 183134 | 211623 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a013 | ||
| 183134 | 211623 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL7550 | 211623 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a013 | ||
| CHEMBL7550 | 211623 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a014 | ||
| 14971639 | 120909 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL332897 | 120909 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971639 | 120909 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL332897 | 120909 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971702 | 213958 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92472 | 213958 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971710 | 214177 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 554 | 10 | 2 | 6 | 7.0 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93886 | 214177 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 554 | 10 | 2 | 6 | 7.0 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971717 | 21354 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.0 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120457 | 21354 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.0 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10369813 | 123758 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.3 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL338740 | 123758 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.3 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 142534045 | 173257 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 543 | 9 | 1 | 7 | 4.9 | CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4278280 | 173257 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 543 | 9 | 1 | 7 | 4.9 | CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956763 | 170176 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL419483 | 170176 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971701 | 214198 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL94002 | 214198 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971708 | 121372 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 508 | 10 | 2 | 7 | 5.4 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL333800 | 121372 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 508 | 10 | 2 | 7 | 5.4 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10393717 | 122877 | 0 | None | 524 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL335722 | 122877 | 0 | None | 524 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| 9914666 | 123448 | 0 | None | 3388 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL337086 | 123448 | 0 | None | 3388 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 14956739 | 213081 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87074 | 213081 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 192567 | 123430 | 6 | None | 223 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL337007 | 123430 | 6 | None | 223 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10140613 | 112873 | 0 | None | 3 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313371 | 112873 | 0 | None | 3 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956772 | 112724 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL312913 | 112724 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 192345 | 33008 | 6 | None | 12022 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL135775 | 33008 | 6 | None | 12022 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 10326140 | 123429 | 0 | None | 2884 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL337006 | 123429 | 0 | None | 2884 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| 9807766 | 77659 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 555 | 9 | 1 | 8 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951136 | 77659 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 555 | 9 | 1 | 8 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 60770 | 176278 | 17 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 506 | 8 | 2 | 6 | 5.1 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL443269 | 176278 | 17 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 506 | 8 | 2 | 6 | 5.1 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 142534141 | 173956 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4291216 | 173956 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956757 | 74367 | 0 | None | 831 | 2 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL19018 | 74367 | 0 | None | 831 | 2 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971700 | 214236 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL94221 | 214236 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9871638 | 77668 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 529 | 11 | 1 | 7 | 5.0 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951144 | 77668 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 529 | 11 | 1 | 7 | 5.0 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44320012 | 174702 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL431411 | 174702 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 155542482 | 179906 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 487 | 9 | 1 | 6 | 5.5 | CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| CHEMBL4520827 | 179906 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 487 | 9 | 1 | 6 | 5.5 | CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| 44213341 | 77652 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 511 | 9 | 1 | 7 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951129 | 77652 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 511 | 9 | 1 | 7 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 137532858 | 173869 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 517 | 9 | 1 | 7 | 4.4 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4289788 | 173869 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 517 | 9 | 1 | 7 | 4.4 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971719 | 121570 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 470 | 8 | 2 | 6 | 4.5 | CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL333978 | 121570 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 470 | 8 | 2 | 6 | 4.5 | CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971711 | 23326 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 479 | 9 | 2 | 7 | 4.7 | CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL123767 | 23326 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 479 | 9 | 2 | 7 | 4.7 | CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971707 | 214115 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 523 | 10 | 2 | 8 | 5.3 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93547 | 214115 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 523 | 10 | 2 | 8 | 5.3 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44213349 | 77658 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 9 | 1 | 8 | 3.2 | CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951135 | 77658 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 9 | 1 | 8 | 3.2 | CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 20081627 | 98945 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL24224 | 98945 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/j.bmc.2010.10.043 | ||
| 145981239 | 173388 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 9 | 1 | 7 | 5.7 | CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4280574 | 173388 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 9 | 1 | 7 | 5.7 | CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 131654 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956781 | 212952 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86314 | 212952 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9845644 | 213212 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87964 | 213212 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 10095589 | 122297 | 0 | None | 851 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL335289 | 122297 | 0 | None | 851 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 19939399 | 112941 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 609 | 11 | 2 | 10 | 5.2 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313696 | 112941 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 609 | 11 | 2 | 10 | 5.2 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10222835 | 212924 | 0 | None | 2 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86084 | 212924 | 0 | None | 2 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 142533975 | 173827 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4288964 | 173827 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44348352 | 23300 | 0 | None | 1 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL123713 | 23300 | 0 | None | 1 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| 14971675 | 213748 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL91287 | 213748 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10048220 | 32961 | 0 | None | 109 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL135704 | 32961 | 0 | None | 109 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 14956760 | 172279 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL424053 | 172279 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956777 | 213108 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 415 | 8 | 1 | 7 | 3.6 | CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87276 | 213108 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 415 | 8 | 1 | 7 | 3.6 | CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 164611301 | 191797 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4854916 | 191797 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 1240113 | 36243 | 7 | None | -3 | 3 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 265 | 3 | 0 | 2 | 4.8 | Cc1cccc(CSc2cccc3cccnc23)c1 | nan | ||
| CHEMBL1384550 | 36243 | 7 | None | -3 | 3 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 265 | 3 | 0 | 2 | 4.8 | Cc1cccc(CSc2cccc3cccnc23)c1 | nan | ||
| 164622816 | 192653 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4868159 | 192653 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 5411796 | 78702 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 335 | 4 | 1 | 3 | 3.9 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl | nan | ||
| CHEMBL1972216 | 78702 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 335 | 4 | 1 | 3 | 3.9 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl | nan | ||
| 5740287 | 46969 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 394 | 6 | 0 | 7 | 4.3 | COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1480264 | 46969 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 394 | 6 | 0 | 7 | 4.3 | COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 | nan | ||
| 5738419 | 55228 | 14 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 2 | 1 | 3 | 4.2 | Oc1cccc2ccc(/C=C/c3cccs3)nc12 | nan | ||
| CHEMBL1555793 | 55228 | 14 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 2 | 1 | 3 | 4.2 | Oc1cccc2ccc(/C=C/c3cccs3)nc12 | nan | ||
| 659124 | 45211 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 406 | 7 | 1 | 7 | 4.4 | CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 | nan | ||
| CHEMBL1463829 | 45211 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 406 | 7 | 1 | 7 | 4.4 | CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 | nan | ||
| 1183382 | 30277 | 15 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O | nan | ||
| CHEMBL1333737 | 30277 | 15 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O | nan | ||
| 1334532 | 43700 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 365 | 2 | 3 | 4 | 3.0 | Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 | nan | ||
| CHEMBL1451169 | 43700 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 365 | 2 | 3 | 4 | 3.0 | Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 | nan | ||
| 10257526 | 119149 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329541 | 119149 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 5952109 | 78821 | 7 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.6 | CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 | nan | ||
| CHEMBL1976317 | 78821 | 7 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.6 | CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 | nan | ||
| 2236648 | 35478 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 355 | 2 | 3 | 3 | 3.0 | CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL1377849 | 35478 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 355 | 2 | 3 | 3 | 3.0 | CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 6154033 | 115258 | 5 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.4 | O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 | nan | ||
| CHEMBL3199403 | 115258 | 5 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.4 | O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 | nan | ||
| 4116022 | 57769 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 368 | 10 | 1 | 9 | 3.4 | CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 | nan | ||
| CHEMBL1578324 | 57769 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 368 | 10 | 1 | 9 | 3.4 | CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 | nan | ||
| 19939367 | 112727 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL312921 | 112727 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956804 | 112776 | 0 | None | 1 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313222 | 112776 | 0 | None | 1 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956792 | 113543 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314447 | 113543 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956754 | 164164 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL407827 | 164164 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956787 | 213126 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 461 | 9 | 1 | 9 | 3.0 | CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87363 | 213126 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 461 | 9 | 1 | 9 | 3.0 | CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44373246 | 175046 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1021/jm9504722 | ||
| CHEMBL433895 | 175046 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1021/jm9504722 | ||
| 14956796 | 212578 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83182 | 212578 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10094520 | 31530 | 0 | None | 11 | 2 | Rabbit | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
| CHEMBL134433 | 31530 | 0 | None | 11 | 2 | Rabbit | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
| 3504072 | 40404 | 12 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 299 | 2 | 2 | 3 | 2.1 | O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 | nan | ||
| CHEMBL1421427 | 40404 | 12 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 299 | 2 | 2 | 3 | 2.1 | O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 | nan | ||
| 869765 | 45362 | 8 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 322 | 5 | 2 | 6 | 3.1 | COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC | nan | ||
| CHEMBL1464917 | 45362 | 8 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 322 | 5 | 2 | 6 | 3.1 | COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC | nan | ||
| 16446215 | 54381 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 467 | 7 | 1 | 6 | 4.3 | Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 | nan | ||
| CHEMBL1546607 | 54381 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 467 | 7 | 1 | 6 | 4.3 | Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 | nan | ||
| 5295671 | 42290 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 314 | 2 | 0 | 6 | 2.1 | CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| CHEMBL1438779 | 42290 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 314 | 2 | 0 | 6 | 2.1 | CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| 1653161 | 47099 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 3 | 3 | 5 | 1.2 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 | nan | ||
| CHEMBL1481281 | 47099 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 3 | 3 | 5 | 1.2 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 | nan | ||
| 14956759 | 212881 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85704 | 212881 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 5335659 | 115240 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 | nan | ||
| CHEMBL3199216 | 115240 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 | nan | ||
| 16446684 | 49769 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 405 | 5 | 1 | 5 | 3.5 | O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl | nan | ||
| CHEMBL1504077 | 49769 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 405 | 5 | 1 | 5 | 3.5 | O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl | nan | ||
| 2426231 | 44897 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 394 | 3 | 3 | 3 | 5.3 | Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| CHEMBL1461119 | 44897 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 394 | 3 | 3 | 3 | 5.3 | Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| 53319274 | 64374 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668000 | 64374 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| 10027714 | 122215 | 0 | None | 398 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL335066 | 122215 | 0 | None | 398 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 14956793 | 213087 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87129 | 213087 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956791 | 213120 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 8 | 2 | 8 | 3.4 | CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87341 | 213120 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 8 | 2 | 8 | 3.4 | CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956798 | 213188 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87798 | 213188 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14951059 | 213208 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87942 | 213208 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 11744670 | 122032 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 5 | 0 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334775 | 122032 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 5 | 0 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 14956742 | 213107 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87275 | 213107 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 5187118 | 58636 | 6 | None | -5 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 338 | 3 | 1 | 3 | 4.8 | Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 | nan | ||
| CHEMBL1585527 | 58636 | 6 | None | -5 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 338 | 3 | 1 | 3 | 4.8 | Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 | nan | ||
| 2313746 | 58894 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl | nan | ||
| CHEMBL1587672 | 58894 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl | nan | ||
| 6917582 | 52447 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1529805 | 52447 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 665535 | 51768 | 6 | None | -1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 425 | 7 | 1 | 9 | 1.8 | COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 | nan | ||
| CHEMBL1523699 | 51768 | 6 | None | -1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 425 | 7 | 1 | 9 | 1.8 | COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 | nan | ||
| 2812568 | 43981 | 5 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 3.8 | O=C(NNc1ccc(Cl)cc1)c1sccc1Cl | nan | ||
| CHEMBL1453309 | 43981 | 5 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 3.8 | O=C(NNc1ccc(Cl)cc1)c1sccc1Cl | nan | ||
| 921731 | 58950 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 321 | 5 | 0 | 7 | 2.1 | O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1588194 | 58950 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 321 | 5 | 0 | 7 | 2.1 | O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 6173110 | 114937 | 4 | None | 1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 331 | 5 | 1 | 4 | 3.3 | COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 | nan | ||
| CHEMBL3196139 | 114937 | 4 | None | 1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 331 | 5 | 1 | 4 | 3.3 | COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 | nan | ||
| 2351493 | 56559 | 2 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 301 | 4 | 1 | 3 | 3.3 | O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 | nan | ||
| CHEMBL1567294 | 56559 | 2 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 301 | 4 | 1 | 3 | 3.3 | O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 | nan | ||
| 11467216 | 129380 | 0 | None | - | 1 | Rabbit | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 567 | 15 | 1 | 10 | 5.2 | CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL360220 | 129380 | 0 | None | - | 1 | Rabbit | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 567 | 15 | 1 | 10 | 5.2 | CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 135457059 | 57789 | 23 | None | -2 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 1 | 5 | 4.2 | Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 | nan | ||
| CHEMBL1578482 | 57789 | 23 | None | -2 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 1 | 5 | 4.2 | Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 | nan | ||
| 2303647 | 35199 | 10 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 262 | 3 | 2 | 4 | 3.1 | NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 | nan | ||
| CHEMBL1375248 | 35199 | 10 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 262 | 3 | 2 | 4 | 3.1 | NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 | nan | ||
| 11328757 | 212746 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL84573 | 212746 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 9896251 | 105549 | 0 | None | 1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | ||
| CHEMBL278176 | 105549 | 0 | None | 1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | ||
| 9958963 | 214011 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92821 | 214011 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971680 | 214150 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 520 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93735 | 214150 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 520 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57391456 | 77666 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 10 | 1 | 8 | 4.4 | CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951142 | 77666 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 10 | 1 | 8 | 4.4 | CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971687 | 21585 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120716 | 21585 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956812 | 113449 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314333 | 113449 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 793621 | 33353 | 8 | None | 1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 281 | 1 | 1 | 5 | 3.3 | CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 | nan | ||
| CHEMBL1361034 | 33353 | 8 | None | 1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 281 | 1 | 1 | 5 | 3.3 | CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 | nan | ||
| 2420694 | 39824 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.8 | Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL1416497 | 39824 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.8 | Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 1477595 | 51433 | 29 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 264 | 3 | 0 | 5 | 1.8 | O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 | nan | ||
| CHEMBL1520753 | 51433 | 29 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 264 | 3 | 0 | 5 | 1.8 | O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 | nan | ||
| 1336836 | 39783 | 10 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 398 | 5 | 0 | 6 | 4.5 | Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 | nan | ||
| CHEMBL1416155 | 39783 | 10 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 398 | 5 | 0 | 6 | 4.5 | Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 | nan | ||
| 135489943 | 114643 | 3 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 387 | 9 | 2 | 5 | 4.0 | CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O | nan | ||
| CHEMBL3192625 | 114643 | 3 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 387 | 9 | 2 | 5 | 4.0 | CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O | nan | ||
| 1139588 | 45135 | 11 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 363 | 5 | 0 | 6 | 3.2 | O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1463168 | 45135 | 11 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 363 | 5 | 0 | 6 | 3.2 | O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 6873170 | 115242 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 249 | 2 | 1 | 3 | 1.2 | S=C(N/N=C/c1ccccc1)N1CCOCC1 | nan | ||
| CHEMBL3199234 | 115242 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 249 | 2 | 1 | 3 | 1.2 | S=C(N/N=C/c1ccccc1)N1CCOCC1 | nan | ||
| 804442 | 60601 | 56 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 289 | 4 | 1 | 2 | 3.7 | O=C(CNc1ccc(Br)cc1)c1ccccc1 | nan | ||
| CHEMBL1604367 | 60601 | 56 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 289 | 4 | 1 | 2 | 3.7 | O=C(CNc1ccc(Br)cc1)c1ccccc1 | nan | ||
| 929469 | 53336 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 5 | 0 | 7 | 1.4 | O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1537991 | 53336 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 5 | 0 | 7 | 1.4 | O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 3244543 | 206275 | 25 | None | -3 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 188 | 0 | 2 | 3 | 2.1 | Cc1cc(C)c2ccc(N)nc2c1O | nan | ||
| CHEMBL591834 | 206275 | 25 | None | -3 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 188 | 0 | 2 | 3 | 2.1 | Cc1cc(C)c2ccc(N)nc2c1O | nan | ||
| 43001 | 59559 | 26 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 230 | 1 | 1 | 4 | 2.0 | Nc1c(N2CCCC2)c2ccccc2oc1=O | nan | ||
| CHEMBL1594894 | 59559 | 26 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 230 | 1 | 1 | 4 | 2.0 | Nc1c(N2CCCC2)c2ccccc2oc1=O | nan | ||
| 788616 | 59848 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 269 | 5 | 1 | 4 | 2.8 | COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 | nan | ||
| CHEMBL1597563 | 59848 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 269 | 5 | 1 | 4 | 2.8 | COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 | nan | ||
| 2998385 | 31926 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 2.7 | CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1347643 | 31926 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 2.7 | CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 9549748 | 30011 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 1 | 1 | 1 | 4.4 | SC1=NCCc2ccccc2C1c1ccccc1Cl | nan | ||
| CHEMBL1331656 | 30011 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 1 | 1 | 1 | 4.4 | SC1=NCCc2ccccc2C1c1ccccc1Cl | nan | ||
| 2939261 | 28887 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 3 | 4 | 3.4 | CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1322052 | 28887 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 3 | 4 | 3.4 | CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 14956799 | 113676 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314590 | 113676 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956766 | 113756 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315128 | 113756 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956813 | 213118 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 477 | 9 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87330 | 213118 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 477 | 9 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44211606 | 107990 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 10 | 1 | 10 | 5.2 | CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295905 | 107990 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 10 | 1 | 10 | 5.2 | CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44246747 | 62611 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| CHEMBL1521291 | 62611 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| CHEMBL1623128 | 62611 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| 135501733 | 43834 | 17 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 336 | 3 | 2 | 5 | 2.4 | Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 | nan | ||
| CHEMBL1452116 | 43834 | 17 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 336 | 3 | 2 | 5 | 2.4 | Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 | nan | ||
| 2898747 | 43540 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 1.8 | O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1449757 | 43540 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 1.8 | O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 788619 | 52341 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 | nan | ||
| CHEMBL1528883 | 52341 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 | nan | ||
| 3648468 | 58281 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 4 | 1 | 3 | 4.6 | O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 | nan | ||
| CHEMBL1582697 | 58281 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 4 | 1 | 3 | 4.6 | O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 | nan | ||
| 135419079 | 36999 | 7 | None | -1 | 4 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 340 | 2 | 2 | 5 | 4.0 | Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O | nan | ||
| CHEMBL1390716 | 36999 | 7 | None | -1 | 4 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 340 | 2 | 2 | 5 | 4.0 | Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O | nan | ||
| 877472 | 43450 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 323 | 4 | 1 | 2 | 4.4 | O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 | nan | ||
| CHEMBL1449035 | 43450 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 323 | 4 | 1 | 2 | 4.4 | O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 | nan | ||
| 902793 | 49987 | 18 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1505893 | 49987 | 18 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 67903280 | 192981 | 0 | None | 4 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4872989 | 192981 | 0 | None | 4 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 44355662 | 33235 | 0 | None | 125 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL135999 | 33235 | 0 | None | 125 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 10004013 | 123471 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 452 | 7 | 1 | 7 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL337217 | 123471 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 452 | 7 | 1 | 7 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 | 10.1021/jm00078a014 | ||
| 14956744 | 212942 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86255 | 212942 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1726745 | 30702 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.4 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl | nan | ||
| CHEMBL1337184 | 30702 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.4 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl | nan | ||
| 5731702 | 193431 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 277 | 3 | 1 | 3 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 | nan | ||
| CHEMBL488140 | 193431 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 277 | 3 | 1 | 3 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 | nan | ||
| 2476054 | 54671 | 3 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 347 | 3 | 3 | 4 | 3.9 | FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 | nan | ||
| CHEMBL1549272 | 54671 | 3 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 347 | 3 | 3 | 4 | 3.9 | FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 | nan | ||
| 2458676 | 38184 | 4 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 6 | 1 | 6 | 2.4 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 | nan | ||
| CHEMBL1402558 | 38184 | 4 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 6 | 1 | 6 | 2.4 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 | nan | ||
| 2221657 | 41289 | 11 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 353 | 2 | 0 | 5 | 3.6 | O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 | nan | ||
| CHEMBL1428950 | 41289 | 11 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 353 | 2 | 0 | 5 | 3.6 | O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 | nan | ||
| 44342039 | 17065 | 0 | None | -21 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL116170 | 17065 | 0 | None | -21 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2426360 | 53661 | 6 | None | -8 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 382 | 3 | 3 | 3 | 4.6 | Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 | nan | ||
| CHEMBL1540808 | 53661 | 6 | None | -8 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 382 | 3 | 3 | 3 | 4.6 | Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 | nan | ||
| 9653239 | 114425 | 5 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 291 | 3 | 2 | 4 | 2.7 | O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O | nan | ||
| CHEMBL3190198 | 114425 | 5 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 291 | 3 | 2 | 4 | 2.7 | O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O | nan | ||
| 5730138 | 41568 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 307 | 4 | 1 | 4 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| CHEMBL1431014 | 41568 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 307 | 4 | 1 | 4 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| 12005285 | 59838 | 6 | None | 3 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 402 | 8 | 1 | 9 | 4.0 | CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1597454 | 59838 | 6 | None | 3 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 402 | 8 | 1 | 9 | 4.0 | CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 1767917 | 38010 | 10 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 375 | 5 | 3 | 4 | 2.2 | Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br | nan | ||
| CHEMBL1401122 | 38010 | 10 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 375 | 5 | 3 | 4 | 2.2 | Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br | nan | ||
| 14956806 | 113707 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 10 | 1 | 8 | 5.0 | CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314810 | 113707 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 10 | 1 | 8 | 5.0 | CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956768 | 113748 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 499 | 8 | 1 | 7 | 5.2 | CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315077 | 113748 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 499 | 8 | 1 | 7 | 5.2 | CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956745 | 213048 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86906 | 213048 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14951062 | 213170 | 0 | None | -1 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87669 | 213170 | 0 | None | -1 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971694 | 21464 | 0 | None | - | 1 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120605 | 21464 | 0 | None | - | 1 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44355660 | 28329 | 0 | None | 89 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL131676 | 28329 | 0 | None | 89 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 10410730 | 31390 | 0 | None | 6 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
| CHEMBL134307 | 31390 | 0 | None | 6 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
| 2898434 | 60642 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 1.9 | O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1604741 | 60642 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 1.9 | O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 3532334 | 49126 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 303 | 2 | 1 | 4 | 3.2 | O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| CHEMBL1498428 | 49126 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 303 | 2 | 1 | 4 | 3.2 | O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| 2640418 | 28920 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 6 | 0 | 6 | 2.5 | O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1322344 | 28920 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 6 | 0 | 6 | 2.5 | O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 5687785 | 115181 | 2 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.2 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL3198576 | 115181 | 2 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.2 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 5735740 | 48424 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 4.5 | CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| CHEMBL1491932 | 48424 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 4.5 | CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| 2320855 | 43326 | 6 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1448161 | 43326 | 6 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 | nan | ||
| 5091521 | 32067 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 402 | 2 | 2 | 9 | 2.9 | CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 | nan | ||
| CHEMBL1348954 | 32067 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 402 | 2 | 2 | 9 | 2.9 | CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 | nan | ||
| 2121806 | 48839 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 266 | 4 | 1 | 6 | 2.3 | CCSc1nnc(NC(=O)c2ccccn2)s1 | nan | ||
| CHEMBL1495849 | 48839 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 266 | 4 | 1 | 6 | 2.3 | CCSc1nnc(NC(=O)c2ccccn2)s1 | nan | ||
| 2733001 | 36070 | 4 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 288 | 5 | 1 | 4 | 3.7 | Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 | nan | ||
| CHEMBL1382939 | 36070 | 4 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 288 | 5 | 1 | 4 | 3.7 | Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 | nan | ||
| 25162518 | 46626 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 417 | 8 | 0 | 6 | 2.7 | O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1477291 | 46626 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 417 | 8 | 0 | 6 | 2.7 | O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 14956784 | 113334 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314179 | 113334 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956764 | 212856 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85541 | 212856 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44355628 | 31678 | 0 | None | 5 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL134567 | 31678 | 0 | None | 5 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
| 10095493 | 32820 | 0 | None | 93 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL135521 | 32820 | 0 | None | 93 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
| 1336623 | 45061 | 20 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 350 | 5 | 0 | 6 | 3.5 | Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 | nan | ||
| CHEMBL1462517 | 45061 | 20 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 350 | 5 | 0 | 6 | 3.5 | Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 | nan | ||
| 2165745 | 41454 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 0.7 | O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1430172 | 41454 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 0.7 | O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 659805 | 28738 | 6 | None | -2 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 302 | 1 | 2 | 4 | 3.7 | ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 | nan | ||
| CHEMBL1320678 | 28738 | 6 | None | -2 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 302 | 1 | 2 | 4 | 3.7 | ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 | nan | ||
| 135415440 | 205829 | 11 | None | -10 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 295 | 3 | 2 | 6 | 3.0 | Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 | nan | ||
| CHEMBL586135 | 205829 | 11 | None | -10 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 295 | 3 | 2 | 6 | 3.0 | Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 | nan | ||
| 579121 | 55906 | 12 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 4.7 | COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 | nan | ||
| CHEMBL1561907 | 55906 | 12 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 4.7 | COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 | nan | ||
| 24983202 | 34587 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 444 | 7 | 1 | 6 | 2.9 | CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| CHEMBL1371002 | 34587 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 444 | 7 | 1 | 6 | 2.9 | CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| 14971686 | 22021 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 507 | 10 | 1 | 8 | 5.2 | CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121125 | 22021 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 507 | 10 | 1 | 8 | 5.2 | CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10414429 | 122775 | 0 | None | 363 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL335535 | 122775 | 0 | None | 363 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
| 10322211 | 176251 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1021/jm00078a013 | ||
| CHEMBL442963 | 176251 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1021/jm00078a013 | ||
| 14956741 | 113831 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315615 | 113831 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44292094 | 108221 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 9 | 1 | 9 | 6.4 | CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL297583 | 108221 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 9 | 1 | 9 | 6.4 | CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 23205 | 123698 | 40 | None | -7 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 262 | 0 | 1 | 4 | 1.2 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 | nan | ||
| CHEMBL338474 | 123698 | 40 | None | -7 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 262 | 0 | 1 | 4 | 1.2 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 | nan | ||
| 24981067 | 51977 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 1 | 7 | 1.8 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| CHEMBL1525764 | 51977 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 1 | 7 | 1.8 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| 768473 | 56745 | 6 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 267 | 6 | 0 | 2 | 3.9 | CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL1568922 | 56745 | 6 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 267 | 6 | 0 | 2 | 3.9 | CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 4799115 | 31302 | 8 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 332 | 3 | 2 | 4 | 4.1 | O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F | nan | ||
| CHEMBL1342423 | 31302 | 8 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 332 | 3 | 2 | 4 | 4.1 | O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F | nan | ||
| 11957260 | 39787 | 6 | None | 5 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 389 | 6 | 2 | 10 | 3.3 | O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| CHEMBL1416184 | 39787 | 6 | None | 5 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 389 | 6 | 2 | 10 | 3.3 | O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 10069786 | 175880 | 0 | None | -19 | 3 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL439968 | 175880 | 0 | None | -19 | 3 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 10393397 | 29571 | 0 | None | 6 | 2 | Rabbit | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL132807 | 29571 | 0 | None | 6 | 2 | Rabbit | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| 568849 | 38495 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 313 | 7 | 0 | 5 | 3.0 | O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1405657 | 38495 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 313 | 7 | 0 | 5 | 3.0 | O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 5720743 | 115027 | 10 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 | nan | ||
| CHEMBL3197070 | 115027 | 10 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 | nan | ||
| 761850 | 45568 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.3 | Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1466556 | 45568 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.3 | Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] | nan | ||
| 142534050 | 173745 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 545 | 11 | 1 | 7 | 5.2 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4287379 | 173745 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 545 | 11 | 1 | 7 | 5.2 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971712 | 106379 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 402 | 8 | 3 | 5 | 3.9 | CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL283975 | 106379 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 402 | 8 | 3 | 5 | 3.9 | CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956756 | 213150 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87513 | 213150 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 20081627 | 98945 | 0 | None | -1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24224 | 98945 | 0 | None | -1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459871 | 99305 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079791 | 99305 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24319 | 99305 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 44459655 | 100000 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079788 | 100000 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24478 | 100000 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459835 | 174818 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079790 | 174818 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL432271 | 174818 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459654 | 174889 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079787 | 174889 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL432847 | 174889 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 22942227 | 77653 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 569 | 10 | 1 | 9 | 3.5 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951130 | 77653 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 569 | 10 | 1 | 9 | 3.5 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 22942226 | 77654 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 554 | 10 | 2 | 8 | 2.8 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951131 | 77654 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 554 | 10 | 2 | 8 | 2.8 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 142534121 | 173500 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 559 | 11 | 1 | 7 | 5.4 | CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4282931 | 173500 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 559 | 11 | 1 | 7 | 5.4 | CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971638 | 121653 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.5 | CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334192 | 121653 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.5 | CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9845644 | 213212 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87964 | 213212 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956779 | 75438 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL19202 | 75438 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 142533975 | 173827 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4288964 | 173827 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 155517399 | 176960 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 557 | 10 | 1 | 6 | 6.8 | CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| CHEMBL4444760 | 176960 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 557 | 10 | 1 | 6 | 6.8 | CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| 14971699 | 119560 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL330571 | 119560 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44213343 | 77649 | 29 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 9 | 1 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951126 | 77649 | 29 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 9 | 1 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 9935106 | 72056 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL18287 | 72056 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44213346 | 77655 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 9 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951132 | 77655 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 9 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971709 | 22119 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 553 | 11 | 2 | 9 | 5.3 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121416 | 22119 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 553 | 11 | 2 | 9 | 5.3 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57401930 | 77643 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 500 | 11 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951120 | 77643 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 500 | 11 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44213342 | 77646 | 15 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 458 | 9 | 2 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951123 | 77646 | 15 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 458 | 9 | 2 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971713 | 174762 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL431887 | 174762 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57393227 | 77657 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 9 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951134 | 77657 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 9 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 108185 | 8395 | 78 | None | -3 | 5 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| 586 | 8395 | 78 | None | -3 | 5 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| CHEMBL907 | 8395 | 78 | None | -3 | 5 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| 14971697 | 118318 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.4 | CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327982 | 118318 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.4 | CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10298977 | 213102 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87239 | 213102 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 131654 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971683 | 21634 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120750 | 21634 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971692 | 119730 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.7 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL331078 | 119730 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.7 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10026868 | 30631 | 0 | None | 331 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL133653 | 30631 | 0 | None | 331 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 14956766 | 113756 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315128 | 113756 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2540 | 11173 | 111 | None | -28 | 28 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1014 | 11173 | 111 | None | -28 | 28 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 10409549 | 122756 | 0 | None | 104 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL335514 | 122756 | 0 | None | 104 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10345459 | 123548 | 0 | None | 43 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
| CHEMBL337663 | 123548 | 0 | None | 43 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
| 25163176 | 50866 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 431 | 8 | 0 | 6 | 2.8 | COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 | nan | ||
| CHEMBL1514866 | 50866 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 431 | 8 | 0 | 6 | 2.8 | COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 | nan | ||
| 3116640 | 27179 | 12 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 542 | 6 | 0 | 7 | 2.1 | O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1306605 | 27179 | 12 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 542 | 6 | 0 | 7 | 2.1 | O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 1653162 | 56771 | 11 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 335 | 3 | 3 | 5 | 1.7 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 | nan | ||
| CHEMBL1569107 | 56771 | 11 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 335 | 3 | 3 | 5 | 1.7 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 | nan | ||
| 11957180 | 29516 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 7 | 2 | 10 | 3.7 | O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| CHEMBL1327721 | 29516 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 7 | 2 | 10 | 3.7 | O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| 11957209 | 49808 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1504429 | 49808 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 9550611 | 56538 | 6 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 6 | 1 | 10 | 3.3 | CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1567159 | 56538 | 6 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 6 | 1 | 10 | 3.3 | CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 780302 | 38657 | 7 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.9 | NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 | nan | ||
| CHEMBL1407100 | 38657 | 7 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.9 | NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 | nan | ||
| 14971681 | 118297 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327862 | 118297 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956771 | 213132 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87392 | 213132 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956750 | 212864 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85596 | 212864 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2412928 | 28489 | 7 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 500 | 7 | 1 | 11 | 1.5 | Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O | nan | ||
| CHEMBL1318653 | 28489 | 7 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 500 | 7 | 1 | 11 | 1.5 | Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O | nan | ||
| 6418891 | 29588 | 13 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 3 | 0 | 4 | 5.7 | FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 | nan | ||
| CHEMBL1328168 | 29588 | 13 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 3 | 0 | 4 | 5.7 | FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 | nan | ||
| 2815589 | 48447 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 272 | 5 | 2 | 3 | 2.2 | NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 | nan | ||
| CHEMBL1492089 | 48447 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 272 | 5 | 2 | 3 | 2.2 | NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 | nan | ||
| 16436605 | 45234 | 9 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 | nan | ||
| CHEMBL1464024 | 45234 | 9 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 | nan | ||
| 11159916 | 130629 | 6 | None | - | 1 | Rabbit | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| CHEMBL362550 | 130629 | 6 | None | - | 1 | Rabbit | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| 442142 | 192249 | 16 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 304 | 1 | 0 | 5 | 1.8 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 | nan | ||
| CHEMBL486196 | 192249 | 16 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 304 | 1 | 0 | 5 | 1.8 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 | nan | ||
| 53317942 | 64372 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1667999 | 64372 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| 14971695 | 21643 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.5 | CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120762 | 21643 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.5 | CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44292181 | 107941 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295529 | 107941 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 9982177 | 33272 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL136028 | 33272 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10275744 | 212897 | 0 | None | 2 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85876 | 212897 | 0 | None | 2 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2939837 | 44046 | 7 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 363 | 2 | 3 | 4 | 3.9 | CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1453857 | 44046 | 7 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 363 | 2 | 3 | 4 | 3.9 | CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 800048 | 31257 | 28 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 252 | 2 | 0 | 4 | 2.6 | CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 | nan | ||
| CHEMBL1342053 | 31257 | 28 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 252 | 2 | 0 | 4 | 2.6 | CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 | nan | ||
| 972880 | 201143 | 10 | None | -6 | 3 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 268 | 3 | 1 | 5 | 3.7 | Cc1cccnc1Nc1nc(-c2ccccn2)cs1 | nan | ||
| CHEMBL528694 | 201143 | 10 | None | -6 | 3 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 268 | 3 | 1 | 5 | 3.7 | Cc1cccnc1Nc1nc(-c2ccccn2)cs1 | nan | ||
| 9660957 | 79531 | 12 | None | -1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 330 | 4 | 0 | 5 | 2.3 | CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 | nan | ||
| CHEMBL1999049 | 79531 | 12 | None | -1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 330 | 4 | 0 | 5 | 2.3 | CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 | nan | ||
| 1472225 | 31516 | 11 | None | -5 | 7 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 3.9 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 | nan | ||
| CHEMBL1344225 | 31516 | 11 | None | -5 | 7 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 3.9 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 | nan | ||
| 3734285 | 53388 | 17 | None | -2 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.8 | CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 | nan | ||
| CHEMBL1538399 | 53388 | 17 | None | -2 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.8 | CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 | nan | ||
| 5335941 | 114686 | 8 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 279 | 2 | 2 | 2 | 3.4 | CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 | nan | ||
| CHEMBL3193181 | 114686 | 8 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 279 | 2 | 2 | 2 | 3.4 | CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 | nan | ||
| 9590741 | 114625 | 5 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 | nan | ||
| CHEMBL3192432 | 114625 | 5 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 | nan | ||
| 2539399 | 46663 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 392 | 4 | 2 | 5 | 2.4 | Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 | nan | ||
| CHEMBL1477553 | 46663 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 392 | 4 | 2 | 5 | 2.4 | Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 | nan | ||
| 11159916 | 130629 | 6 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| CHEMBL362550 | 130629 | 6 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| 2283939 | 51188 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 404 | 8 | 1 | 6 | 3.7 | Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1518619 | 51188 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 404 | 8 | 1 | 6 | 3.7 | Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] | nan | ||
| 14971685 | 163298 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 582 | 11 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL406791 | 163298 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 582 | 11 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10113613 | 113536 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 7 | 1 | 7 | 4.0 | CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314436 | 113536 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 7 | 1 | 7 | 4.0 | CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956797 | 213198 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87885 | 213198 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10048776 | 122000 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334622 | 122000 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 1096078 | 56394 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 364 | 4 | 1 | 4 | 4.2 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 | nan | ||
| CHEMBL1566084 | 56394 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 364 | 4 | 1 | 4 | 4.2 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 | nan | ||
| 2645512 | 39234 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 455 | 6 | 0 | 6 | 3.3 | O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1411597 | 39234 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 455 | 6 | 0 | 6 | 3.3 | O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 2171031 | 45947 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 356 | 8 | 1 | 6 | 1.7 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1469682 | 45947 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 356 | 8 | 1 | 6 | 1.7 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 889369 | 61260 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 315 | 3 | 3 | 4 | 3.0 | CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1609718 | 61260 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 315 | 3 | 3 | 4 | 3.0 | CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 2905495 | 26792 | 14 | None | 1 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 400 | 4 | 1 | 9 | 3.3 | Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C | nan | ||
| CHEMBL1303426 | 26792 | 14 | None | 1 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 400 | 4 | 1 | 9 | 3.3 | Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C | nan | ||
| 3239204 | 60791 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 319 | 4 | 1 | 7 | 4.0 | COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 | nan | ||
| CHEMBL1605977 | 60791 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 319 | 4 | 1 | 7 | 4.0 | COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 | nan | ||
| 2848041 | 28854 | 6 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 | nan | ||
| CHEMBL1321754 | 28854 | 6 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 | nan | ||
| 1472220 | 48669 | 11 | None | 3 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 | nan | ||
| CHEMBL1494120 | 48669 | 11 | None | 3 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 | nan | ||
| 135636104 | 50849 | 9 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 217 | 3 | 1 | 5 | 2.7 | O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 | nan | ||
| CHEMBL1514691 | 50849 | 9 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 217 | 3 | 1 | 5 | 2.7 | O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 | nan | ||
| 936147 | 59444 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 306 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 | nan | ||
| CHEMBL1593888 | 59444 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 306 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 | nan | ||
| 8480343 | 50685 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 330 | 4 | 2 | 5 | 2.2 | Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 | nan | ||
| CHEMBL1512236 | 50685 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 330 | 4 | 2 | 5 | 2.2 | Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 | nan | ||
| 2632794 | 29533 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 312 | 5 | 0 | 4 | 3.5 | O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1327815 | 29533 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 312 | 5 | 0 | 4 | 3.5 | O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 14956786 | 113742 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 9 | 2 | 8 | 2.8 | CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315012 | 113742 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 9 | 2 | 8 | 2.8 | CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10250898 | 125266 | 0 | None | 37 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL341407 | 125266 | 0 | None | 37 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
| 6908540 | 114525 | 19 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 305 | 5 | 1 | 5 | 1.9 | O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 | nan | ||
| CHEMBL3191392 | 114525 | 19 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 305 | 5 | 1 | 5 | 1.9 | O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 | nan | ||
| 2739277 | 36464 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 364 | 4 | 2 | 5 | 4.3 | O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 | nan | ||
| CHEMBL1386393 | 36464 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 364 | 4 | 2 | 5 | 4.3 | O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 | nan | ||
| 135478724 | 41905 | 33 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 240 | 1 | 1 | 2 | 2.9 | O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 | nan | ||
| CHEMBL1434292 | 41905 | 33 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 240 | 1 | 1 | 2 | 2.9 | O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 | nan | ||
| 3118020 | 54260 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 400 | 6 | 0 | 7 | 1.7 | CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O | nan | ||
| CHEMBL1545561 | 54260 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 400 | 6 | 0 | 7 | 1.7 | CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O | nan | ||
| 164613537 | 191905 | 0 | None | 21 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4856425 | 191905 | 0 | None | 21 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 10025873 | 122312 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 433 | 4 | 0 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335323 | 122312 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 433 | 4 | 0 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 14956765 | 213201 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87890 | 213201 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 773605 | 51952 | 22 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 253 | 2 | 2 | 3 | 3.3 | Fc1ccc(NC(S)=Nc2nccs2)cc1 | nan | ||
| CHEMBL1525546 | 51952 | 22 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 253 | 2 | 2 | 3 | 3.3 | Fc1ccc(NC(S)=Nc2nccs2)cc1 | nan | ||
| 3754656 | 54706 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 362 | 8 | 1 | 6 | 2.6 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 | nan | ||
| CHEMBL1549587 | 54706 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 362 | 8 | 1 | 6 | 2.6 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 | nan | ||
| 933895 | 29490 | 32 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 166 | 2 | 2 | 5 | 1.0 | CC(C)c1nc(C#N)c(NN)o1 | nan | ||
| CHEMBL1327546 | 29490 | 32 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 166 | 2 | 2 | 5 | 1.0 | CC(C)c1nc(C#N)c(NN)o1 | nan | ||
| 42600949 | 61160 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| CHEMBL1608922 | 61160 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| CHEMBL2131333 | 61160 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| 2811327 | 41098 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 288 | 4 | 2 | 2 | 4.0 | CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| CHEMBL1427235 | 41098 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 288 | 4 | 2 | 2 | 4.0 | CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| 2896074 | 52434 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 491 | 3 | 2 | 7 | 5.2 | O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 | nan | ||
| CHEMBL1529705 | 52434 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 491 | 3 | 2 | 7 | 5.2 | O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 | nan | ||
| 2813088 | 55320 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 290 | 3 | 2 | 5 | 2.9 | Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 | nan | ||
| CHEMBL1556712 | 55320 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 290 | 3 | 2 | 5 | 2.9 | Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 | nan | ||
| 6887818 | 114914 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 430 | 4 | 1 | 4 | 4.8 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 | nan | ||
| CHEMBL3195898 | 114914 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 430 | 4 | 1 | 4 | 4.8 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 | nan | ||
| 2883150 | 57722 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 413 | 9 | 2 | 7 | 2.7 | CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1577988 | 57722 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 413 | 9 | 2 | 7 | 2.7 | CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| 14956788 | 113807 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 447 | 9 | 2 | 8 | 2.9 | CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315469 | 113807 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 447 | 9 | 2 | 8 | 2.9 | CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2321121 | 62228 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1412385 | 62228 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1619819 | 62228 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2378336 | 42897 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 271 | 6 | 2 | 4 | 2.5 | COc1ccc(C(=O)CNc2ccccc2CO)cc1 | nan | ||
| CHEMBL1444275 | 42897 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 271 | 6 | 2 | 4 | 2.5 | COc1ccc(C(=O)CNc2ccccc2CO)cc1 | nan | ||
| 3118009 | 51419 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.4 | O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1520643 | 51419 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.4 | O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 135492609 | 115033 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 521 | 2 | 1 | 7 | 3.6 | CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 | nan | ||
| CHEMBL3197135 | 115033 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 521 | 2 | 1 | 7 | 3.6 | CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 | nan | ||
| 183134 | 211623 | 17 | None | -134 | 7 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| CHEMBL7550 | 211623 | 17 | None | -134 | 7 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| 11527144 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL297425 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47177 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956749 | 212997 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86613 | 212997 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956803 | 213064 | 0 | None | 10 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86986 | 213064 | 0 | None | 10 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956767 | 213166 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87650 | 213166 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54500223 | 77647 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 444 | 8 | 2 | 7 | 3.0 | CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951124 | 77647 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 444 | 8 | 2 | 7 | 3.0 | CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 324450 | 47689 | 25 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 219 | 3 | 2 | 3 | 1.4 | O=C(CCl)NNc1cccc(Cl)n1 | nan | ||
| CHEMBL1486528 | 47689 | 25 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 219 | 3 | 2 | 3 | 1.4 | O=C(CCl)NNc1cccc(Cl)n1 | nan | ||
| 3103390 | 51613 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 410 | 7 | 1 | 7 | 2.1 | O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1522230 | 51613 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 410 | 7 | 1 | 7 | 2.1 | O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 1231596 | 42624 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 406 | 4 | 1 | 7 | 4.2 | COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O | nan | ||
| CHEMBL1441794 | 42624 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 406 | 4 | 1 | 7 | 4.2 | COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O | nan | ||
| 9653430 | 78522 | 3 | None | -3 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 331 | 3 | 2 | 3 | 4.2 | COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 | nan | ||
| CHEMBL1966283 | 78522 | 3 | None | -3 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 331 | 3 | 2 | 3 | 4.2 | COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 | nan | ||
| 161167 | 102266 | 40 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 3.0 | O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 | nan | ||
| CHEMBL257286 | 102266 | 40 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 3.0 | O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 | nan | ||
| 3235730 | 58915 | 12 | None | -2 | 3 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 432 | 8 | 1 | 9 | 3.4 | CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N | nan | ||
| CHEMBL1587831 | 58915 | 12 | None | -2 | 3 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 432 | 8 | 1 | 9 | 3.4 | CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N | nan | ||
| 793994 | 114479 | 7 | None | -1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 | nan | ||
| CHEMBL3190827 | 114479 | 7 | None | -1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 | nan | ||
| 135444079 | 45917 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 270 | 1 | 1 | 2 | 3.7 | Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 | nan | ||
| CHEMBL1469448 | 45917 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 270 | 1 | 1 | 2 | 3.7 | Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 | nan | ||
| 2412176 | 61679 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 259 | 5 | 1 | 3 | 3.1 | COc1ccc(C(=O)CNc2cccc(F)c2)cc1 | nan | ||
| CHEMBL1613520 | 61679 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 259 | 5 | 1 | 3 | 3.1 | COc1ccc(C(=O)CNc2cccc(F)c2)cc1 | nan | ||
| 10411101 | 172444 | 0 | None | 676 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL424465 | 172444 | 0 | None | 676 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
| 10371403 | 73696 | 20 | None | - | 1 | Rabbit | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL186572 | 73696 | 20 | None | - | 1 | Rabbit | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 3119388 | 54110 | 12 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 556 | 7 | 0 | 7 | 2.5 | O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1544373 | 54110 | 12 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 556 | 7 | 0 | 7 | 2.5 | O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 4691872 | 54032 | 1 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.8 | COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 | nan | ||
| CHEMBL1543866 | 54032 | 1 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.8 | COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 | nan | ||
| 135557876 | 115032 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 326 | 4 | 3 | 6 | 2.4 | Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O | nan | ||
| CHEMBL3197126 | 115032 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 326 | 4 | 3 | 6 | 2.4 | Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O | nan | ||
| 2767330 | 103149 | 26 | None | 1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 272 | 1 | 0 | 3 | 3.7 | Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| CHEMBL261693 | 103149 | 26 | None | 1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 272 | 1 | 0 | 3 | 3.7 | Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| 852940 | 56615 | 12 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 257 | 2 | 1 | 5 | 3.0 | CCc1cc2c(O)nc(-c3ccccn3)nc2s1 | nan | ||
| CHEMBL1567827 | 56615 | 12 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 257 | 2 | 1 | 5 | 3.0 | CCc1cc2c(O)nc(-c3ccccn3)nc2s1 | nan | ||
| 3138587 | 41293 | 3 | None | 1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 391 | 6 | 5 | 10 | -2.3 | CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 | nan | ||
| CHEMBL1428985 | 41293 | 3 | None | 1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 391 | 6 | 5 | 10 | -2.3 | CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 | nan | ||
| 1472222 | 35463 | 11 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 3.6 | COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 | nan | ||
| CHEMBL1377737 | 35463 | 11 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 3.6 | COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 | nan | ||
| 135443160 | 38491 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 435 | 2 | 1 | 5 | 4.5 | O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 | nan | ||
| CHEMBL1405610 | 38491 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 435 | 2 | 1 | 5 | 4.5 | O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 | nan | ||
| 2920316 | 44448 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 446 | 9 | 1 | 6 | 3.6 | Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1457414 | 44448 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 446 | 9 | 1 | 6 | 3.6 | Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| 4146306 | 31991 | 2 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 347 | 2 | 1 | 4 | 3.3 | O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| CHEMBL1348215 | 31991 | 2 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 347 | 2 | 1 | 4 | 3.3 | O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 20081616 | 99015 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 6 | 2 | 8 | 5.3 | Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24266 | 99015 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 6 | 2 | 8 | 5.3 | Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459656 | 106402 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079789 | 106402 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL284140 | 106402 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| 14956814 | 212579 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 493 | 10 | 1 | 7 | 4.8 | CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83194 | 212579 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 493 | 10 | 1 | 7 | 4.8 | CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971703 | 113865 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL315878 | 113865 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956761 | 112748 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313025 | 112748 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956778 | 213072 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87057 | 213072 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44320509 | 213117 | 0 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL87327 | 213117 | 0 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 22942224 | 77660 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 11 | 1 | 9 | 3.9 | CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951137 | 77660 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 11 | 1 | 9 | 3.9 | CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44292471 | 164331 | 0 | None | - | 1 | Bovine | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 563 | 10 | 3 | 8 | 5.0 | CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| CHEMBL408033 | 164331 | 0 | None | - | 1 | Bovine | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 563 | 10 | 3 | 8 | 5.0 | CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| 54277224 | 77656 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 540 | 9 | 1 | 8 | 3.1 | CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951133 | 77656 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 540 | 9 | 1 | 8 | 3.1 | CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971718 | 22304 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 388 | 7 | 3 | 5 | 3.5 | CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121847 | 22304 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 388 | 7 | 3 | 5 | 3.5 | CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956753 | 113847 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315776 | 113847 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971721 | 119960 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 544 | 8 | 2 | 6 | 6.3 | O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| CHEMBL331475 | 119960 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 544 | 8 | 2 | 6 | 6.3 | O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| 4673492 | 10910 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| 8324 | 10910 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| CHEMBL159096 | 10910 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| 14971689 | 18980 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 5.4 | CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL118431 | 18980 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 5.4 | CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44211605 | 177539 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 10 | 1 | 10 | 5.0 | CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44526 | 177539 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 10 | 1 | 10 | 5.0 | CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956809 | 112969 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 656 | 15 | 1 | 9 | 6.5 | CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313837 | 112969 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 656 | 15 | 1 | 9 | 6.5 | CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 132562 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm9504722 | ||
| CHEMBL284536 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm9504722 | ||
| 57403666 | 77645 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 472 | 9 | 1 | 8 | 3.5 | CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951122 | 77645 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 472 | 9 | 1 | 8 | 3.5 | CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O | 10.1016/j.bmcl.2011.12.116 | ||
| 57396698 | 77650 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 513 | 11 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951127 | 77650 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 513 | 11 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 6918269 | 105246 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL275875 | 105246 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295959 | 105246 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10027636 | 31366 | 0 | None | 70 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL134286 | 31366 | 0 | None | 70 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 135406019 | 30805 | 15 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 264 | 2 | 1 | 3 | 3.0 | CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 | nan | ||
| CHEMBL1338100 | 30805 | 15 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 264 | 2 | 1 | 3 | 3.0 | CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 | nan | ||
| 3395163 | 36610 | 5 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 441 | 11 | 1 | 7 | 3.5 | CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1387520 | 36610 | 5 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 441 | 11 | 1 | 7 | 3.5 | CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 16012865 | 30113 | 9 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 480 | 6 | 1 | 7 | 2.6 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| CHEMBL1332454 | 30113 | 9 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 480 | 6 | 1 | 7 | 2.6 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| 67903275 | 193302 | 5 | None | 257 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4877651 | 193302 | 5 | None | 257 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 142534170 | 173583 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 591 | 9 | 1 | 7 | 5.8 | CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4284403 | 173583 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 591 | 9 | 1 | 7 | 5.8 | CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44292039 | 188872 | 1 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 547 | 8 | 1 | 8 | 5.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47817 | 188872 | 1 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 547 | 8 | 1 | 8 | 5.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956801 | 212889 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85765 | 212889 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10251520 | 105597 | 0 | None | - | 1 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 419 | 5 | 0 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL278656 | 105597 | 0 | None | - | 1 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 419 | 5 | 0 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 5731496 | 59957 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 281 | 2 | 1 | 2 | 4.8 | Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 | nan | ||
| CHEMBL1598569 | 59957 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 281 | 2 | 1 | 2 | 4.8 | Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 | nan | ||
| 1613606 | 54797 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 392 | 8 | 1 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1550301 | 54797 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 392 | 8 | 1 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| 44417426 | 148354 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 | 10.1021/jm0603163 | ||
| CHEMBL384936 | 148354 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 | 10.1021/jm0603163 | ||
| 14956751 | 213080 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87073 | 213080 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956802 | 213094 | 0 | None | 1 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87184 | 213094 | 0 | None | 1 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 9126 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 3941 | 9126 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 3961 | 9126 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 590 | 9126 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL191 | 9126 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| DB00678 | 9126 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 44355656 | 122862 | 0 | None | - | 1 | Rabbit | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 467 | 6 | 1 | 6 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335680 | 122862 | 0 | None | - | 1 | Rabbit | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 467 | 6 | 1 | 6 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 | 10.1021/jm00078a013 | ||
| 44202070 | 46392 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 271 | 1 | 0 | 2 | 3.5 | Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 | nan | ||
| CHEMBL1474191 | 46392 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 271 | 1 | 0 | 2 | 3.5 | Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 | nan | ||
| 1730709 | 30812 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 370 | 8 | 1 | 6 | 3.0 | Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1338165 | 30812 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 370 | 8 | 1 | 6 | 3.0 | Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2899190 | 59325 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1592181 | 59325 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] | nan | ||
| 2285607 | 45335 | 10 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 400 | 9 | 1 | 7 | 3.1 | COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1464749 | 45335 | 10 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 400 | 9 | 1 | 7 | 3.1 | COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 | nan | ||
| 44201736 | 34235 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 586 | 9 | 2 | 5 | 5.2 | O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 | nan | ||
| CHEMBL1368499 | 34235 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 586 | 9 | 2 | 5 | 5.2 | O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 | nan | ||
| 16195321 | 57816 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 413 | 6 | 0 | 5 | 4.9 | CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 | nan | ||
| CHEMBL1578651 | 57816 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 413 | 6 | 0 | 5 | 4.9 | CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 | nan | ||
| 10344571 | 123392 | 0 | None | 125 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336773 | 123392 | 0 | None | 125 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 4210369 | 49204 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 4.0 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl | nan | ||
| CHEMBL1499072 | 49204 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 4.0 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl | nan | ||
| 1726742 | 40169 | 13 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 398 | 9 | 1 | 7 | 2.9 | CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1419495 | 40169 | 13 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 398 | 9 | 1 | 7 | 2.9 | CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| 9548123 | 54538 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1548173 | 54538 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 5416363 | 114960 | 3 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 3.5 | C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 | nan | ||
| CHEMBL3196324 | 114960 | 3 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 3.5 | C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 | nan | ||
| 44292214 | 182669 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 9 | 2 | 9 | 4.6 | CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45864 | 182669 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 9 | 2 | 9 | 4.6 | CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10364891 | 33017 | 0 | None | 33 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL135792 | 33017 | 0 | None | 33 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
| 9550553 | 61295 | 6 | None | 2 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1610025 | 61295 | 6 | None | 2 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 1266032 | 47652 | 6 | None | 3 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 343 | 2 | 0 | 3 | 4.9 | O=C(Sc1cccc2cccnc12)c1ccccc1Br | nan | ||
| CHEMBL1486214 | 47652 | 6 | None | 3 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 343 | 2 | 0 | 3 | 4.9 | O=C(Sc1cccc2cccnc12)c1ccccc1Br | nan | ||
| 9608279 | 114567 | 6 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 366 | 6 | 1 | 8 | 3.1 | COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 | nan | ||
| CHEMBL3191846 | 114567 | 6 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 366 | 6 | 1 | 8 | 3.1 | COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 | nan | ||
| 5341487 | 79126 | 15 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 317 | 3 | 1 | 3 | 3.0 | C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 | nan | ||
| CHEMBL1984876 | 79126 | 15 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 317 | 3 | 1 | 3 | 3.0 | C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 | nan | ||
| 11100 | 132734 | 80 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 192 | 3 | 1 | 4 | 1.8 | O=C(c1ccco1)C(O)c1ccco1 | nan | ||
| CHEMBL364893 | 132734 | 80 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 192 | 3 | 1 | 4 | 1.8 | O=C(c1ccco1)C(O)c1ccco1 | nan | ||
| 135472780 | 35219 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C | nan | ||
| CHEMBL1375373 | 35219 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C | nan | ||
| 2360979 | 45724 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 275 | 5 | 1 | 3 | 3.6 | COc1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1467838 | 45724 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 275 | 5 | 1 | 3 | 3.6 | COc1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| 3106500 | 31561 | 9 | None | -1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 306 | 3 | 1 | 7 | 1.5 | CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 | nan | ||
| CHEMBL1344603 | 31561 | 9 | None | -1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 306 | 3 | 1 | 7 | 1.5 | CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 | nan | ||
| 2431535 | 45697 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 343 | 4 | 0 | 4 | 4.1 | O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl | nan | ||
| CHEMBL1467556 | 45697 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 343 | 4 | 0 | 4 | 4.1 | O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl | nan | ||
| 2324620 | 31671 | 14 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 455 | 4 | 4 | 4 | 4.3 | CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O | nan | ||
| CHEMBL1345564 | 31671 | 14 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 455 | 4 | 4 | 4 | 4.3 | CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O | nan | ||
| 1875884 | 31276 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 436 | 5 | 3 | 6 | 3.0 | COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 | nan | ||
| CHEMBL1342221 | 31276 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 436 | 5 | 3 | 6 | 3.0 | COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 | nan | ||
| 16012896 | 39773 | 10 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 7 | 1 | 7 | 3.0 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 | nan | ||
| CHEMBL1416089 | 39773 | 10 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 7 | 1 | 7 | 3.0 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 | nan | ||
| 2352555 | 59146 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 | nan | ||
| CHEMBL1589900 | 59146 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 | nan | ||
| 3146836 | 114435 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 5.6 | CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 | nan | ||
| CHEMBL3190347 | 114435 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 5.6 | CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 | nan | ||
| 135400342 | 46540 | 7 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 2 | 7 | 2.2 | O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 | nan | ||
| CHEMBL1476264 | 46540 | 7 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 2 | 7 | 2.2 | O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 | nan | ||
| 1612942 | 47610 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 370 | 7 | 1 | 6 | 2.4 | Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1485784 | 47610 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 370 | 7 | 1 | 6 | 2.4 | Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 | nan | ||
| 24818379 | 47872 | 5 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 353 | 6 | 2 | 8 | 1.3 | COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1487991 | 47872 | 5 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 353 | 6 | 2 | 8 | 1.3 | COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] | nan | ||
| 82533 | 47818 | 70 | None | -6 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 | nan | ||
| CHEMBL1487635 | 47818 | 70 | None | -6 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 | nan | ||
| 5286934 | 56075 | 8 | None | -2 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 294 | 9 | 0 | 4 | 2.4 | CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC | nan | ||
| CHEMBL1563483 | 56075 | 8 | None | -2 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 294 | 9 | 0 | 4 | 2.4 | CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC | nan | ||
| 930382 | 40783 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1424582 | 40783 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 2811457 | 41195 | 5 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 4 | 2 | 4 | 3.2 | Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 | nan | ||
| CHEMBL1428121 | 41195 | 5 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 4 | 2 | 4 | 3.2 | Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 | nan | ||
| 14971679 | 118428 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 608 | 10 | 1 | 7 | 7.8 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL328598 | 118428 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 608 | 10 | 1 | 7 | 7.8 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 108185 | 8395 | 78 | None | -3 | 5 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | ||
| 586 | 8395 | 78 | None | -3 | 5 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | ||
| CHEMBL907 | 8395 | 78 | None | -3 | 5 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | ||
| 108185 | 8395 | 78 | None | -3 | 5 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 586 | 8395 | 78 | None | -3 | 5 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| CHEMBL907 | 8395 | 78 | None | -3 | 5 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 14956783 | 212555 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 414 | 8 | 1 | 8 | 2.8 | CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL82920 | 212555 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 414 | 8 | 1 | 8 | 2.8 | CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9612783 | 114701 | 3 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 345 | 6 | 1 | 4 | 3.7 | C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 | nan | ||
| CHEMBL3193378 | 114701 | 3 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 345 | 6 | 1 | 4 | 3.7 | C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 | nan | ||
| 142534004 | 174137 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4294618 | 174137 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 15229102 | 107969 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295695 | 107969 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 9982458 | 33282 | 0 | None | - | 1 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL136034 | 33282 | 0 | None | - | 1 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 | 10.1021/jm00078a014 | ||
| 1720698 | 26311 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 378 | 8 | 1 | 7 | 1.3 | O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1299557 | 26311 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 378 | 8 | 1 | 7 | 1.3 | O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2812498 | 50417 | 5 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 362 | 5 | 2 | 4 | 4.3 | Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 | nan | ||
| CHEMBL1509694 | 50417 | 5 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 362 | 5 | 2 | 4 | 4.3 | Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 | nan | ||
| 888488 | 57472 | 11 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 301 | 5 | 0 | 7 | 1.7 | Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1575784 | 57472 | 11 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 301 | 5 | 0 | 7 | 1.7 | Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] | nan | ||
| 2766929 | 57084 | 26 | None | -20 | 4 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 287 | 1 | 0 | 4 | 3.1 | CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 | nan | ||
| CHEMBL1572001 | 57084 | 26 | None | -20 | 4 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 287 | 1 | 0 | 4 | 3.1 | CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 | nan | ||
| 130606 | 43044 | 54 | None | 1 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.4 | COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 | nan | ||
| CHEMBL1445650 | 43044 | 54 | None | 1 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.4 | COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 | nan | ||
| 44292173 | 179231 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44798 | 179231 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 164616479 | 192095 | 0 | None | 16 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4859498 | 192095 | 0 | None | 16 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2426323 | 44345 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.6 | Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| CHEMBL1456428 | 44345 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.6 | Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| 1472216 | 57387 | 12 | None | -3 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 384 | 6 | 1 | 4 | 3.6 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 | nan | ||
| CHEMBL1574879 | 57387 | 12 | None | -3 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 384 | 6 | 1 | 4 | 3.6 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 | nan | ||
| 135421501 | 56604 | 16 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 344 | 2 | 1 | 3 | 3.8 | COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| CHEMBL1567702 | 56604 | 16 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 344 | 2 | 1 | 3 | 3.8 | COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| 16193016 | 62903 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1602056 | 62903 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1625597 | 62903 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| 3368605 | 26593 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O | nan | ||
| CHEMBL1301939 | 26593 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O | nan | ||
| 2114872 | 27555 | 6 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 2 | 1 | 4 | 3.1 | O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 | nan | ||
| CHEMBL1309573 | 27555 | 6 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 2 | 1 | 4 | 3.1 | O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 | nan | ||
| 2928370 | 52241 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 3.2 | CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 | nan | ||
| CHEMBL1528033 | 52241 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 3.2 | CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 | nan | ||
| 135426090 | 41120 | 12 | None | 3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 318 | 3 | 2 | 6 | 4.0 | Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 | nan | ||
| CHEMBL1427431 | 41120 | 12 | None | 3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 318 | 3 | 2 | 6 | 4.0 | Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 | nan | ||
| 135632169 | 58443 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| 136087362 | 58443 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| CHEMBL1583998 | 58443 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| 10456041 | 32627 | 0 | None | 186 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135346 | 32627 | 0 | None | 186 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 44459595 | 106233 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079785 | 106233 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL283055 | 106233 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459878 | 106483 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 8 | 1 | 9 | 4.6 | COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL284704 | 106483 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 8 | 1 | 9 | 4.6 | COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 53657506 | 77661 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 557 | 10 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951138 | 77661 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 557 | 10 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956738 | 212577 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83180 | 212577 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9870652 | 77667 | 75 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL1951143 | 77667 | 75 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 11974939 | 88914 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 5 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL216747 | 88914 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 5 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 10183373 | 171789 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL422593 | 171789 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10183373 | 171789 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL422593 | 171789 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54199501 | 77642 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 486 | 10 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951119 | 77642 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 486 | 10 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 54558598 | 77651 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 10 | 1 | 7 | 3.8 | CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951128 | 77651 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 10 | 1 | 7 | 3.8 | CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 142534183 | 174048 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 503 | 8 | 1 | 7 | 4.0 | CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4293170 | 174048 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 503 | 8 | 1 | 7 | 4.0 | CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956794 | 212857 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85545 | 212857 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 5335625 | 115470 | 10 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 3 | 1 | 3 | 3.2 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL3208035 | 115470 | 10 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 3 | 1 | 3 | 3.2 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 46495021 | 114605 | 5 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 315 | 5 | 1 | 7 | 1.7 | O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | nan | ||
| CHEMBL3192235 | 114605 | 5 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 315 | 5 | 1 | 7 | 1.7 | O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | nan | ||
| 14971636 | 121591 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 6.0 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334083 | 121591 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 6.0 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44292040 | 107912 | 0 | None | - | 1 | Bovine | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 601 | 9 | 1 | 9 | 6.9 | CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295279 | 107912 | 0 | None | - | 1 | Bovine | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 601 | 9 | 1 | 9 | 6.9 | CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 5759185 | 45451 | 5 | None | -5 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 300 | 4 | 0 | 6 | 2.8 | CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 | nan | ||
| CHEMBL1465592 | 45451 | 5 | None | -5 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 300 | 4 | 0 | 6 | 2.8 | CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 | nan | ||
| 5217512 | 49174 | 5 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 278 | 3 | 3 | 5 | 2.8 | NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 | nan | ||
| CHEMBL1498886 | 49174 | 5 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 278 | 3 | 3 | 5 | 2.8 | NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 | nan | ||
| 10371403 | 73696 | 20 | None | - | 1 | Rabbit | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL186572 | 73696 | 20 | None | - | 1 | Rabbit | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 14956743 | 170884 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL420970 | 170884 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 56991879 | 77644 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 528 | 13 | 1 | 8 | 4.9 | CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951121 | 77644 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 528 | 13 | 1 | 8 | 4.9 | CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 9618012 | 84693 | 4 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 289 | 3 | 1 | 3 | 3.4 | C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 | nan | ||
| CHEMBL2094484 | 84693 | 4 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 289 | 3 | 1 | 3 | 3.4 | C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 | nan | ||
| 1475345 | 36009 | 11 | None | -1 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 | nan | ||
| CHEMBL1382438 | 36009 | 11 | None | -1 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 | nan | ||
| 18666499 | 182398 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 591 | 9 | 2 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45805 | 182398 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 591 | 9 | 2 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 11743704 | 122276 | 0 | None | 3 | 2 | Rabbit | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
| CHEMBL335179 | 122276 | 0 | None | 3 | 2 | Rabbit | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
| 44292038 | 189314 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47873 | 189314 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 5218417 | 31586 | 6 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 285 | 3 | 0 | 2 | 3.9 | CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 | nan | ||
| CHEMBL1344824 | 31586 | 6 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 285 | 3 | 0 | 2 | 3.9 | CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 | nan | ||
| 10411653 | 31196 | 0 | None | 208 | 2 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL134151 | 31196 | 0 | None | 208 | 2 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
| 14956799 | 113676 | 0 | None | - | 1 | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314590 | 113676 | 0 | None | - | 1 | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 6873617 | 79192 | 5 | None | -3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 386 | 4 | 1 | 4 | 4.7 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 | nan | ||
| CHEMBL1987579 | 79192 | 5 | None | -3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 386 | 4 | 1 | 4 | 4.7 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 | nan | ||
| 10367704 | 29115 | 0 | None | 25 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL132408 | 29115 | 0 | None | 25 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 131654 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956748 | 212752 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL84627 | 212752 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9887844 | 169979 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm9504722 | ||
| CHEMBL418226 | 169979 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm9504722 | ||
| 54393565 | 77662 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951139 | 77662 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 10004112 | 32302 | 0 | None | 93 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL135089 | 32302 | 0 | None | 93 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 10344052 | 123385 | 0 | None | 107 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336738 | 123385 | 0 | None | 107 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 142534191 | 173562 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 9 | 1 | 8 | 4.2 | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4284022 | 173562 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 9 | 1 | 8 | 4.2 | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956758 | 113308 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314042 | 113308 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956769 | 113893 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL316052 | 113893 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956762 | 105606 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL278741 | 105606 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54479908 | 77664 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 525 | 10 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951140 | 77664 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 525 | 10 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956759 | 212881 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85704 | 212881 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956800 | 212929 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86143 | 212929 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 14956805 | 213123 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87354 | 213123 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9893748 | 189303 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 9 | 2 | 9 | 4.5 | CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47872 | 189303 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 9 | 2 | 9 | 4.5 | CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 742856 | 60543 | 21 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 4 | 1 | 2 | 4.3 | O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1603871 | 60543 | 21 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 4 | 1 | 2 | 4.3 | O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 | nan | ||
| 14956789 | 213218 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 10 | 1 | 9 | 3.7 | CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL88002 | 213218 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 10 | 1 | 9 | 3.7 | CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2811329 | 35425 | 5 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 3 | 2 | 4 | 3.0 | Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl | nan | ||
| CHEMBL1377329 | 35425 | 5 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 3 | 2 | 4 | 3.0 | Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl | nan | ||
| 4328866 | 26265 | 3 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 247 | 3 | 0 | 4 | 1.2 | CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 | nan | ||
| CHEMBL1299266 | 26265 | 3 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 247 | 3 | 0 | 4 | 1.2 | CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 | nan | ||
| 5770964 | 33228 | 2 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 2.6 | COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 | nan | ||
| CHEMBL1359902 | 33228 | 2 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 2.6 | COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 | nan | ||
| 2744279 | 33432 | 2 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 351 | 5 | 0 | 10 | 2.5 | CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C | nan | ||
| CHEMBL1361740 | 33432 | 2 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 351 | 5 | 0 | 10 | 2.5 | CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C | nan | ||
| 4068403 | 27494 | 11 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] | nan | ||
| CHEMBL1309127 | 27494 | 11 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] | nan | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 788411 | 34143 | 13 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| CHEMBL1367827 | 34143 | 13 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| 14971674 | 214079 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93289 | 214079 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 15233933 | 107942 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295532 | 107942 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14971693 | 119688 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.5 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL331063 | 119688 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.5 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 18655851 | 108078 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 623 | 9 | 1 | 8 | 6.7 | CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296519 | 108078 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 623 | 9 | 1 | 8 | 6.7 | CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 100520 | 39499 | 6 | None | -4 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 240 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cnc(Sc2ccncn2)s1 | nan | ||
| CHEMBL1413680 | 39499 | 6 | None | -4 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 240 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cnc(Sc2ccncn2)s1 | nan | ||
| 788410 | 27939 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(NCC(=O)c2ccccc2)cc1Cl | nan | ||
| CHEMBL1312651 | 27939 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(NCC(=O)c2ccccc2)cc1Cl | nan | ||
| 44292072 | 108077 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 9 | 1 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296518 | 108077 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 9 | 1 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956773 | 212874 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 504 | 9 | 2 | 6 | 5.0 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85659 | 212874 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 504 | 9 | 2 | 6 | 5.0 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00069a015 | ||
| 44292162 | 179070 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44749 | 179070 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 16446380 | 38396 | 9 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 447 | 7 | 1 | 7 | 3.4 | COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 | nan | ||
| CHEMBL1404578 | 38396 | 9 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 447 | 7 | 1 | 7 | 3.4 | COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 | nan | ||
| 718402 | 40662 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 | nan | ||
| CHEMBL1423567 | 40662 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 | nan | ||
| 16437205 | 38777 | 9 | None | -5 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| CHEMBL1407961 | 38777 | 9 | None | -5 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| 6873485 | 114355 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 7 | 1 | 5 | 4.9 | CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 | nan | ||
| CHEMBL3189289 | 114355 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 7 | 1 | 5 | 4.9 | CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 | nan | ||
| 9569064 | 79025 | 2 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 363 | 6 | 1 | 4 | 4.0 | C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 | nan | ||
| CHEMBL1981898 | 79025 | 2 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 363 | 6 | 1 | 4 | 4.0 | C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 | nan | ||
| 1481 | 8847 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 3749 | 8847 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 589 | 8847 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 6908 | 8847 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL1513 | 8847 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| DB01029 | 8847 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 108185 | 8395 | 78 | None | -3 | 5 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 586 | 8395 | 78 | None | -3 | 5 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| CHEMBL907 | 8395 | 78 | None | -3 | 5 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 57393229 | 77669 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.5 | CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951145 | 77669 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.5 | CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956740 | 212587 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83248 | 212587 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971677 | 118288 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327837 | 118288 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956775 | 210760 | 0 | None | -1 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL69508 | 210760 | 0 | None | -1 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956808 | 213210 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 1 | 9 | 4.9 | CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87957 | 213210 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 1 | 9 | 4.9 | CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 330973 | 56463 | 3 | None | -16 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 592 | 4 | 0 | 10 | 3.0 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 | nan | ||
| CHEMBL1566610 | 56463 | 3 | None | -16 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 592 | 4 | 0 | 10 | 3.0 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 | nan | ||
| 2812572 | 31796 | 5 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 274 | 4 | 2 | 2 | 3.7 | CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 | nan | ||
| CHEMBL1346661 | 31796 | 5 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 274 | 4 | 2 | 2 | 3.7 | CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 | nan | ||
| 890649 | 60404 | 14 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 3.6 | O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 | nan | ||
| CHEMBL1602759 | 60404 | 14 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 3.6 | O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 | nan | ||
| 44292456 | 107939 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 9 | 1 | 9 | 5.6 | CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295514 | 107939 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 9 | 1 | 9 | 5.6 | CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 16436607 | 30837 | 10 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 | nan | ||
| CHEMBL1338304 | 30837 | 10 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 | nan | ||
| 9619214 | 114854 | 6 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 351 | 5 | 1 | 8 | 2.9 | Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 | nan | ||
| CHEMBL3195226 | 114854 | 6 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 351 | 5 | 1 | 8 | 2.9 | Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 | nan | ||
| 11744592 | 122281 | 0 | None | 33 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335228 | 122281 | 0 | None | 33 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
| 6091989 | 56626 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 337 | 5 | 1 | 5 | 4.1 | COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC | nan | ||
| CHEMBL1567899 | 56626 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 337 | 5 | 1 | 5 | 4.1 | COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC | nan | ||
| 44292070 | 178633 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44690 | 178633 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44292342 | 184038 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL46361 | 184038 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 6883924 | 78466 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 315 | 3 | 1 | 4 | 3.7 | O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl | nan | ||
| CHEMBL1964873 | 78466 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 315 | 3 | 1 | 4 | 3.7 | O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl | nan | ||
| 10366811 | 31598 | 0 | None | 31 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL134491 | 31598 | 0 | None | 31 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
| 3117 | 214620 | 103 | None | -9 | 24 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| CHEMBL964 | 214620 | 103 | None | -9 | 24 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| 780062 | 35720 | 7 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 276 | 3 | 2 | 4 | 3.4 | Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 | nan | ||
| CHEMBL1380035 | 35720 | 7 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 276 | 3 | 2 | 4 | 3.4 | Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 | nan | ||
| 10048602 | 32822 | 0 | None | 37 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
| CHEMBL135522 | 32822 | 0 | None | 37 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
| 9556585 | 161691 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.6 | O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 | nan | ||
| CHEMBL400912 | 161691 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.6 | O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 | nan | ||
| 14956800 | 212929 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86143 | 212929 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956810 | 212938 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 566 | 10 | 1 | 8 | 5.9 | CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86232 | 212938 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 566 | 10 | 1 | 8 | 5.9 | CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 135449568 | 48436 | 3 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 286 | 4 | 2 | 7 | 2.5 | COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 | nan | ||
| CHEMBL1492017 | 48436 | 3 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 286 | 4 | 2 | 7 | 2.5 | COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 | nan | ||
| 44292428 | 107871 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 644 | 9 | 1 | 9 | 5.3 | CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL294992 | 107871 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 644 | 9 | 1 | 9 | 5.3 | CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44291956 | 178053 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 619 | 10 | 1 | 10 | 5.3 | CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44605 | 178053 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 619 | 10 | 1 | 10 | 5.3 | CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956746 | 212973 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86440 | 212973 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 379338 | 23661 | 26 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 288 | 2 | 0 | 4 | 3.4 | COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| CHEMBL125044 | 23661 | 26 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 288 | 2 | 0 | 4 | 3.4 | COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| 14956807 | 112901 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 566 | 12 | 1 | 9 | 4.9 | CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313435 | 112901 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 566 | 12 | 1 | 9 | 4.9 | CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956755 | 112926 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313579 | 112926 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10202093 | 213214 | 0 | None | 2 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87985 | 213214 | 0 | None | 2 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 145987183 | 174011 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 9 | 1 | 7 | 6.1 | CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4292297 | 174011 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 9 | 1 | 7 | 6.1 | CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44291955 | 103401 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL263471 | 103401 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 18942289 | 108107 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 6.8 | CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296719 | 108107 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 6.8 | CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10003482 | 172522 | 0 | None | 158 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL424643 | 172522 | 0 | None | 158 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 14956776 | 112745 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313017 | 112745 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956790 | 178129 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 10 | 2 | 8 | 3.6 | CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL446152 | 178129 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 10 | 2 | 8 | 3.6 | CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 851388 | 62000 | 12 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| CHEMBL1328306 | 62000 | 12 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| CHEMBL1617841 | 62000 | 12 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| 1728272 | 51609 | 12 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 309 | 5 | 3 | 4 | 1.5 | CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 | nan | ||
| CHEMBL1522211 | 51609 | 12 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 309 | 5 | 3 | 4 | 1.5 | CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 | nan | ||
| 135411933 | 47991 | 21 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 300 | 1 | 1 | 2 | 3.5 | O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 | nan | ||
| CHEMBL1488802 | 47991 | 21 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 300 | 1 | 1 | 2 | 3.5 | O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 | nan | ||
| 2796987 | 30145 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 288 | 5 | 2 | 3 | 2.7 | NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1332717 | 30145 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 288 | 5 | 2 | 3 | 2.7 | NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| 379337 | 170986 | 27 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 258 | 1 | 0 | 3 | 3.4 | O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 | nan | ||
| CHEMBL421088 | 170986 | 27 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 258 | 1 | 0 | 3 | 3.4 | O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 | nan | ||
| 788612 | 59100 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 | nan | ||
| CHEMBL1589540 | 59100 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 | nan | ||
| 583493 | 49508 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 255 | 5 | 2 | 3 | 2.7 | O=C(CNc1ccccc1C(=O)O)c1ccccc1 | nan | ||
| CHEMBL1501792 | 49508 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 255 | 5 | 2 | 3 | 2.7 | O=C(CNc1ccccc1C(=O)O)c1ccccc1 | nan | ||
| 1593681 | 37138 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 9 | 2 | 8 | 1.1 | O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1391919 | 37138 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 9 | 2 | 8 | 1.1 | O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 10258828 | 21431 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 498 | 9 | 1 | 7 | 5.0 | CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120549 | 21431 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 498 | 9 | 1 | 7 | 5.0 | CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971696 | 120205 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 9 | 1 | 7 | 6.7 | CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| CHEMBL331886 | 120205 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 9 | 1 | 7 | 6.7 | CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| 14956782 | 213184 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 457 | 8 | 1 | 7 | 3.8 | CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87780 | 213184 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 457 | 8 | 1 | 7 | 3.8 | CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44341650 | 176666 | 0 | None | -2 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL444060 | 176666 | 0 | None | -2 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 135400371 | 60074 | 20 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 314 | 1 | 1 | 2 | 3.8 | Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 | nan | ||
| CHEMBL1599499 | 60074 | 20 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 314 | 1 | 1 | 2 | 3.8 | Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 | nan | ||
| 135403068 | 30275 | 15 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 358 | 3 | 1 | 3 | 4.2 | CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| CHEMBL1333730 | 30275 | 15 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 358 | 3 | 1 | 3 | 4.2 | CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| 6884203 | 115021 | 10 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 352 | 4 | 1 | 4 | 4.1 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 | nan | ||
| CHEMBL3197021 | 115021 | 10 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 352 | 4 | 1 | 4 | 4.1 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 | nan | ||
| 2989697 | 55522 | 17 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.4 | CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 | nan | ||
| CHEMBL1558462 | 55522 | 17 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.4 | CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 | nan | ||
| 10435200 | 30635 | 0 | None | - | 1 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 478 | 5 | 1 | 7 | 4.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 | 10.1021/jm00078a013 | ||
| CHEMBL133654 | 30635 | 0 | None | - | 1 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 478 | 5 | 1 | 7 | 4.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 | 10.1021/jm00078a013 | ||
| 5953874 | 47876 | 5 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 277 | 2 | 1 | 6 | 2.8 | N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 | nan | ||
| CHEMBL1488024 | 47876 | 5 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 277 | 2 | 1 | 6 | 2.8 | N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 | nan | ||
| 9675542 | 114586 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.8 | Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 | nan | ||
| CHEMBL3191999 | 114586 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.8 | Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 | nan | ||
| 44292215 | 182219 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 605 | 9 | 1 | 10 | 4.8 | CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45766 | 182219 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 605 | 9 | 1 | 10 | 4.8 | CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956774 | 213017 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86741 | 213017 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 6873171 | 115501 | 6 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 283 | 2 | 1 | 3 | 1.9 | S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 | nan | ||
| CHEMBL3208447 | 115501 | 6 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 283 | 2 | 1 | 3 | 1.9 | S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 | nan | ||
| 14971678 | 21317 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120290 | 21317 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10365283 | 32625 | 0 | None | 416 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135345 | 32625 | 0 | None | 416 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10223724 | 212536 | 0 | None | 1 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL82797 | 212536 | 0 | None | 1 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10479472 | 122003 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 462 | 6 | 1 | 7 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334660 | 122003 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 462 | 6 | 1 | 7 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 10344235 | 212939 | 0 | None | -1 | 3 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL86247 | 212939 | 0 | None | -1 | 3 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 10322504 | 33155 | 0 | None | 19 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135929 | 33155 | 0 | None | 19 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 14956747 | 212753 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL84630 | 212753 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971673 | 119137 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.8 | CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329466 | 119137 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.8 | CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 5339648 | 79727 | 13 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 270 | 4 | 1 | 5 | 1.8 | O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL2005961 | 79727 | 13 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 270 | 4 | 1 | 5 | 1.8 | O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 10322995 | 122041 | 0 | None | 134 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
| CHEMBL334832 | 122041 | 0 | None | 134 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
| 10026268 | 123708 | 0 | None | 173 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL338505 | 123708 | 0 | None | 173 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
| 854200 | 42806 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 239 | 4 | 1 | 2 | 3.6 | Cc1ccc(C(=O)CNc2ccccc2C)cc1 | nan | ||
| CHEMBL1443417 | 42806 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 239 | 4 | 1 | 2 | 3.6 | Cc1ccc(C(=O)CNc2ccccc2C)cc1 | nan | ||
| 973504 | 101997 | 9 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL256042 | 101997 | 9 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 | nan | ||
| 44292180 | 187727 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47583 | 187727 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 200953 | 52613 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 196 | 1 | 0 | 2 | 2.5 | O=C(C#Cc1ccccc1)c1ccco1 | nan | ||
| CHEMBL1531308 | 52613 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 196 | 1 | 0 | 2 | 2.5 | O=C(C#Cc1ccccc1)c1ccco1 | nan | ||
| 2812483 | 50358 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 245 | 3 | 2 | 4 | 2.4 | Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 | nan | ||
| CHEMBL1509162 | 50358 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 245 | 3 | 2 | 4 | 2.4 | Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 | nan | ||
| 6873172 | 115859 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 263 | 2 | 1 | 3 | 1.5 | Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 | nan | ||
| CHEMBL3213140 | 115859 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 263 | 2 | 1 | 3 | 1.5 | Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 | nan | ||
| 10437543 | 33039 | 0 | None | 7 | 2 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135819 | 33039 | 0 | None | 7 | 2 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| 878879 | 44958 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccccc1NCC(=O)c1ccc(Br)cc1 | nan | ||
| CHEMBL1461745 | 44958 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccccc1NCC(=O)c1ccc(Br)cc1 | nan | ||
| 44341785 | 16919 | 0 | None | -3 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL115771 | 16919 | 0 | None | -3 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 6792924 | 114765 | 10 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 259 | 3 | 1 | 3 | 2.5 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL3194040 | 114765 | 10 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 259 | 3 | 1 | 3 | 2.5 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 | nan | ||
| 1511959 | 27897 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 359 | 3 | 0 | 8 | 2.0 | CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| CHEMBL1312377 | 27897 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 359 | 3 | 0 | 8 | 2.0 | CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| 10050755 | 122289 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 478 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL335276 | 122289 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 478 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 | 10.1021/jm00078a014 | ||
| 54508770 | 77648 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 472 | 10 | 2 | 7 | 3.8 | CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951125 | 77648 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 472 | 10 | 2 | 7 | 3.8 | CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971682 | 118264 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 11 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327718 | 118264 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 11 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956771 | 213132 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87392 | 213132 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 57393228 | 77665 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 539 | 10 | 1 | 7 | 4.7 | CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951141 | 77665 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 539 | 10 | 1 | 7 | 4.7 | CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971676 | 170153 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL419321 | 170153 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956776 | 112745 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313017 | 112745 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 824082 | 33254 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 2.6 | Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1360149 | 33254 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 2.6 | Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 | nan | ||
| 2564786 | 51474 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 225 | 4 | 1 | 2 | 3.3 | Cc1ccc(C(=O)CNc2ccccc2)cc1 | nan | ||
| CHEMBL1521054 | 51474 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 225 | 4 | 1 | 2 | 3.3 | Cc1ccc(C(=O)CNc2ccccc2)cc1 | nan | ||
| 11754335 | 32075 | 0 | None | 186 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL134901 | 32075 | 0 | None | 186 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
| 1625575 | 61059 | 10 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.5 | CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 | nan | ||
| CHEMBL1608078 | 61059 | 10 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.5 | CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 | nan | ||
| 5680364 | 61678 | 5 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 272 | 2 | 1 | 4 | 0.9 | CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 | nan | ||
| CHEMBL1613515 | 61678 | 5 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 272 | 2 | 1 | 4 | 0.9 | CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 | nan | ||
| 2411934 | 62224 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| CHEMBL1409219 | 62224 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| CHEMBL1619798 | 62224 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| 2170433 | 52965 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 2.3 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1534477 | 52965 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 2.3 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 9590742 | 114350 | 3 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 | nan | ||
| CHEMBL3189245 | 114350 | 3 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 | nan | ||
| 10434876 | 123396 | 0 | None | 7 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336808 | 123396 | 0 | None | 7 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 2474590 | 49940 | 4 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 291 | 2 | 1 | 4 | 3.2 | O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 | nan | ||
| CHEMBL1505604 | 49940 | 4 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 291 | 2 | 1 | 4 | 3.2 | O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 | nan | ||
| 9667523 | 115627 | 8 | None | -3 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 328 | 6 | 1 | 6 | 2.3 | C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 | nan | ||
| CHEMBL3210072 | 115627 | 8 | None | -3 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 328 | 6 | 1 | 6 | 2.3 | C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 | nan | ||
| 14956770 | 213036 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 7 | 1 | 9 | 3.7 | O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86853 | 213036 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 7 | 1 | 9 | 3.7 | O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956785 | 213171 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 460 | 9 | 2 | 8 | 2.6 | CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87682 | 213171 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 460 | 9 | 2 | 8 | 2.6 | CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1487013 | 58738 | 16 | None | 1 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 317 | 3 | 1 | 6 | 1.4 | CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1586425 | 58738 | 16 | None | 1 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 317 | 3 | 1 | 6 | 1.4 | CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 | nan | ||
| 5337284 | 52480 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 | nan | ||
| CHEMBL1530173 | 52480 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 | nan | ||
| 991372 | 60624 | 33 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 382 | 1 | 2 | 5 | 4.5 | CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O | nan | ||
| CHEMBL1604546 | 60624 | 33 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 382 | 1 | 2 | 5 | 4.5 | CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O | nan | ||
| 135472791 | 29107 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 | nan | ||
| CHEMBL1324011 | 29107 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 | nan | ||
| 788618 | 26776 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 | nan | ||
| CHEMBL1303334 | 26776 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 | nan | ||
| 788408 | 50319 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 | nan | ||
| CHEMBL1508797 | 50319 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 | nan | ||
| 6918269 | 105246 | 11 | None | 5 | 2 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL275875 | 105246 | 11 | None | 5 | 2 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL295959 | 105246 | 11 | None | 5 | 2 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 11527144 | 185884 | 0 | None | - | 1 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL297425 | 185884 | 0 | None | - | 1 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL47177 | 185884 | 0 | None | - | 1 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 133031 | 107636 | 21 | None | -1 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL293511 | 107636 | 21 | None | -1 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9887844 | 169979 | 4 | None | - | 1 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL418226 | 169979 | 4 | None | - | 1 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| 9911332 | 51475 | 1 | None | - | 0 | Rabbit | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 444 | 7 | 2 | 6 | 4.7 | CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9604383 | ||
| CHEMBL152106 | 51475 | 1 | None | - | 0 | Rabbit | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 444 | 7 | 2 | 6 | 4.7 | CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9604383 | ||
| 132387 | 169113 | 23 | None | - | 0 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL416477 | 169113 | 23 | None | - | 0 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 108185 | 8395 | 78 | None | -3 | 5 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 586 | 8395 | 78 | None | -3 | 5 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL907 | 8395 | 78 | None | -3 | 5 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 9802561 | 168030 | 26 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10.0 | Functional | ChEMBL | 426 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL41194 | 168030 | 26 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10.0 | Functional | ChEMBL | 426 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| 19890807 | 118311 | 0 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10 | Functional | ChEMBL | 466 | 8 | 1 | 7 | 5.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 | 10.1021/jm00070a012 | ||
| CHEMBL327932 | 118311 | 0 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10 | Functional | ChEMBL | 466 | 8 | 1 | 7 | 5.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 | 10.1021/jm00070a012 | ||
| 15657904 | 194261 | 4 | None | - | 0 | Rabbit | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL49410 | 194261 | 4 | None | - | 0 | Rabbit | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 19017678 | 182932 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 474 | 11 | 2 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL45927 | 182932 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 474 | 11 | 2 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 9935096 | 214550 | 1 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9599 | 214550 | 1 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44373246 | 175046 | 0 | None | - | 1 | Rabbit | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL433895 | 175046 | 0 | None | - | 1 | Rabbit | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL2373017 | 217133 | 0 | None | - | 0 | Rat | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCSSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O | 10.1021/jm00169a019 | ||||
| 9912059 | 192135 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Functional | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL48602 | 192135 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Functional | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 131654 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL87778 | 213182 | 12 | None | 1 | 2 | Rabbit | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9801006 | 126507 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL347610 | 126507 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1016/j.bmc.2010.10.043 | ||
| 178553 | 127022 | 14 | None | - | 0 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 387 | 6 | 1 | 6 | 4.1 | COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL352257 | 127022 | 14 | None | - | 0 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 387 | 6 | 1 | 6 | 4.1 | COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1016/j.bmc.2010.10.043 | ||
| 70682146 | 83106 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058860 | 83106 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 46910493 | 83110 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058864 | 83110 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 9931685 | 212863 | 0 | None | 1 | 2 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL85595 | 212863 | 0 | None | 1 | 2 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | ||
| 131857 | 211038 | 20 | None | - | 0 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 383 | 5 | 1 | 4 | 5.0 | Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL71162 | 211038 | 20 | None | - | 0 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 383 | 5 | 1 | 4 | 5.0 | Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438885 | 97729 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Functional | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL239378 | 97729 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Functional | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 2541 | 7573 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 587 | 7573 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 6907 | 7573 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL1016 | 7573 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| DB00796 | 7573 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| DB13919 | 7573 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 10094851 | 28069 | 0 | None | - | 1 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL131365 | 28069 | 0 | None | - | 1 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 1610 | 9126 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 3941 | 9126 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 3961 | 9126 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 590 | 9126 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL191 | 9126 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| DB00678 | 9126 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 24827770 | 102655 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| CHEMBL259114 | 102655 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| 44438869 | 153113 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL392118 | 153113 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | ||
| 44438900 | 154626 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL393305 | 154626 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44570265 | 185188 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 519 | 12 | 2 | 5 | 5.9 | CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL465929 | 185188 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 519 | 12 | 2 | 5 | 5.9 | CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 19351553 | 125476 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 389 | 10 | 4 | 6 | 3.1 | CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL341716 | 125476 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 389 | 10 | 4 | 6 | 3.1 | CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL264230 | 217388 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | ||||
| CHEMBL384349 | 219102 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | ||||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 44438865 | 100150 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL245644 | 100150 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 44570305 | 197097 | 0 | None | - | 0 | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 545 | 10 | 2 | 5 | 6.4 | CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL517626 | 197097 | 0 | None | - | 0 | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 545 | 10 | 2 | 5 | 6.4 | CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 44348352 | 23300 | 0 | None | 1 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL123713 | 23300 | 0 | None | 1 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 44570215 | 190330 | 0 | None | - | 0 | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 477 | 9 | 2 | 5 | 4.7 | CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL480018 | 190330 | 0 | None | - | 0 | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 477 | 9 | 2 | 5 | 4.7 | CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9906367 | 58923 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 3.1 | C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL158794 | 58923 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 3.1 | C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438902 | 176175 | 0 | None | - | 1 | Rabbit | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL442251 | 176175 | 0 | None | - | 1 | Rabbit | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 46910495 | 83107 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058861 | 83107 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 24828707 | 102712 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| CHEMBL259353 | 102712 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| 44438870 | 98780 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241685 | 98780 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 10250336 | 25658 | 0 | None | - | 1 | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL128318 | 25658 | 0 | None | - | 1 | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 53323218 | 67026 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668010 | 67026 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1741079 | 67026 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 25110812 | 185818 | 0 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 455 | 9 | 2 | 4 | 6.1 | CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL471334 | 185818 | 0 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 455 | 9 | 2 | 4 | 6.1 | CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 44570214 | 190329 | 0 | None | - | 0 | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 463 | 8 | 2 | 5 | 4.4 | CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL480017 | 190329 | 0 | None | - | 0 | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 463 | 8 | 2 | 5 | 4.4 | CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9932483 | 214622 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9642 | 214622 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9954408 | 214746 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9714 | 214746 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 25112615 | 192670 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 503 | 9 | 2 | 4 | 7.0 | CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL486847 | 192670 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 503 | 9 | 2 | 4 | 7.0 | CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 44570306 | 185076 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 464 | 8 | 2 | 5 | 5.0 | CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL465097 | 185076 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 464 | 8 | 2 | 5 | 5.0 | CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 15224471 | 161612 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL400424 | 161612 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 2541 | 7573 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 587 | 7573 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 6907 | 7573 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL1016 | 7573 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| DB00796 | 7573 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| DB13919 | 7573 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 4110026 | 211714 | 1 | None | - | 2 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL7632 | 211714 | 1 | None | - | 2 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 57380647 | 77129 | 0 | None | - | 2 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1945010 | 77129 | 0 | None | - | 2 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 9823146 | 26133 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL12909 | 26133 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 9126 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3941 | 9126 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3961 | 9126 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 590 | 9126 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL191 | 9126 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| DB00678 | 9126 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 9801627 | 58836 | 17 | None | - | 0 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 409 | 7 | 1 | 6 | 4.7 | CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL158725 | 58836 | 17 | None | - | 0 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 409 | 7 | 1 | 6 | 4.7 | CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 17748251 | 100122 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL245444 | 100122 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44570266 | 197594 | 0 | None | - | 0 | Rat | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 519 | 9 | 2 | 5 | 5.9 | CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL518388 | 197594 | 0 | None | - | 0 | Rat | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 519 | 9 | 2 | 5 | 5.9 | CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9938452 | 124693 | 0 | None | - | 0 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 591 | 13 | 2 | 6 | 8.1 | CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL340315 | 124693 | 0 | None | - | 0 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 591 | 13 | 2 | 6 | 8.1 | CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 17748251 | 100122 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL245444 | 100122 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438868 | 98779 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241684 | 98779 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44438901 | 98762 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241529 | 98762 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 25112616 | 192671 | 0 | None | - | 0 | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL486848 | 192671 | 0 | None | - | 0 | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL415157 | 219953 | 0 | None | - | 0 | Rabbit | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | ||||
| 1610 | 9126 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 3941 | 9126 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 3961 | 9126 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 590 | 9126 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL191 | 9126 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| DB00678 | 9126 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 25112614 | 198402 | 0 | None | - | 0 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL519564 | 198402 | 0 | None | - | 0 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 70686410 | 83105 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058859 | 83105 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 57380414 | 77305 | 0 | None | - | 2 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1947131 | 77305 | 0 | None | - | 2 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 44339988 | 167786 | 0 | None | - | 0 | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| CHEMBL411624 | 167786 | 0 | None | - | 0 | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| 132562 | 106459 | 6 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL284536 | 106459 | 6 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | ||
| 53325868 | 64375 | 0 | None | - | 0 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 515 | 12 | 2 | 6 | 5.8 | CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668002 | 64375 | 0 | None | - | 0 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 515 | 12 | 2 | 6 | 5.8 | CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438880 | 98761 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241523 | 98761 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 132706 | 8457 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| 6896 | 8457 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL315021 | 8457 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| DB01342 | 8457 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| 57380412 | 77303 | 0 | None | - | 2 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1947129 | 77303 | 0 | None | - | 2 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 44570264 | 197486 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 505 | 10 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL518230 | 197486 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 505 | 10 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 25112617 | 193536 | 0 | None | - | 0 | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL488883 | 193536 | 0 | None | - | 0 | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL268804 | 217543 | 0 | None | - | 0 | Rabbit | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | ||||
| 44438872 | 175885 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL440051 | 175885 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 15069306 | 185841 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 2 | 4 | 6.5 | CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL471505 | 185841 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 2 | 4 | 6.5 | CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 44570217 | 190013 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 505 | 11 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL479626 | 190013 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 505 | 11 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 44570216 | 196836 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 5.1 | CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL517230 | 196836 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 5.1 | CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 6918269 | 105246 | 11 | None | - | 2 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL275875 | 105246 | 11 | None | - | 2 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL295959 | 105246 | 11 | None | - | 2 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 1610 | 9126 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3941 | 9126 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3961 | 9126 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 590 | 9126 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| CHEMBL191 | 9126 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| DB00678 | 9126 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 6917 | 6920 | 0 | None | - | 1 | Human | 7.8 | pA2 | = | 7.8 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 73755250 | 6920 | 0 | None | - | 1 | Human | 7.8 | pA2 | = | 7.8 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 11943 | 10647 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 145925549 | 10647 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| CHEMBL4438122 | 10647 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 123814 | 7209 | 30 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 12006574 | ||||
| 5368 | 7209 | 30 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 12006574 | ||||
| CHEMBL261120 | 7209 | 30 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 12006574 | ||||
| 6894 | 7206 | 0 | None | -56 | 3 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 21464395 | ||||
| 91691124 | 7206 | 0 | None | -56 | 3 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 21464395 | ||||
| 6905 | 10258 | 0 | None | - | 1 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 7499361 | ||||
| 135409642 | 224514 | 0 | None | 1 | 2 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 | None | ||
| 2540 | 11173 | 111 | None | 1 | 28 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| CHEMBL1014 | 11173 | 111 | None | 1 | 28 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| 3839 | 10529 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 60919 | 10529 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 6898 | 10529 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| CHEMBL432162 | 10529 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| DB01349 | 10529 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 130881 | 9695 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 1985 | 9695 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 591 | 9695 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| CHEMBL1200692 | 9695 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| DB00275 | 9695 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 130881 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 1985 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 591 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| CHEMBL1200692 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| DB00275 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 135409642 | 224514 | 0 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 | None | ||
| 16133225 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 172198 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 2504 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 45266664 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 5272 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| CHEMBL408403 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| DB11842 | 7207 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 9870652 | 77667 | 75 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| CHEMBL1951143 | 77667 | 75 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| 1610 | 9126 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3941 | 9126 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3961 | 9126 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 590 | 9126 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| CHEMBL191 | 9126 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| DB00678 | 9126 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3936 | 8991 | 35 | None | -1 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| 6603900 | 8991 | 35 | None | -1 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| CHEMBL288174 | 8991 | 35 | None | -1 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| 6895 | 8992 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 580 | 9 | 1 | 6 | 6.6 | CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C | 9383393 | ||
| 73755245 | 8992 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 580 | 9 | 1 | 6 | 6.6 | CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C | 9383393 | ||
| 1610 | 9126 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 3941 | 9126 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 3961 | 9126 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 590 | 9126 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| CHEMBL191 | 9126 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| DB00678 | 9126 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 139031070 | 9614 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 6911 | 9614 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 73755247 | 9614 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 130881 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 1985 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 591 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| CHEMBL1200692 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| DB00275 | 9695 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 135415867 | 7348 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| 135415867 | 7348 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| 6901 | 7348 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| 6901 | 7348 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| CHEMBL57242 | 7348 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| CHEMBL57242 | 7348 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| 6909 | 9187 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 73755246 | 9187 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 10416728 | 9188 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 6910 | 9188 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| CHEMBL344662 | 9188 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 132706 | 8457 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| 6896 | 8457 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| CHEMBL315021 | 8457 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| DB01342 | 8457 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| 2583 | 10548 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 592 | 10548 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 65999 | 10548 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| CHEMBL1017 | 10548 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| DB00966 | 10548 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 4673492 | 10910 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| 8324 | 10910 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| CHEMBL159096 | 10910 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| 108185 | 8395 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| 108185 | 8395 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| 586 | 8395 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| 586 | 8395 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| CHEMBL907 | 8395 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| CHEMBL907 | 8395 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| 44299731 | 7208 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 585 | 7208 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| CHEMBL56448 | 7208 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 6917 | 6920 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 73755250 | 6920 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 1037 | 8359 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 3940 | 8359 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 5281037 | 8359 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 588 | 8359 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| CHEMBL813 | 8359 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| DB00876 | 8359 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 2806 | 10741 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 3937 | 10741 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 593 | 10741 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 60846 | 10741 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| CHEMBL1069 | 10741 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| DB00177 | 10741 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 1481 | 8847 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 3749 | 8847 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 589 | 8847 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 6908 | 8847 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| CHEMBL1513 | 8847 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| DB01029 | 8847 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 136218976 | 6938 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | ||
| 6913 | 6938 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | ||
| 2806 | 10741 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 3937 | 10741 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 593 | 10741 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 60846 | 10741 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| CHEMBL1069 | 10741 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| DB00177 | 10741 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 3839 | 10529 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 60919 | 10529 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 6898 | 10529 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| CHEMBL432162 | 10529 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| DB01349 | 10529 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 16133225 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 172198 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 2504 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 45266664 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 5272 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| CHEMBL408403 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| DB11842 | 7207 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 6894 | 7206 | 0 | None | -2 | 3 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 17138938 | ||||
| 91691124 | 7206 | 0 | None | -2 | 3 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 17138938 | ||||
| 2541 | 7573 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| 587 | 7573 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| 6907 | 7573 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| CHEMBL1016 | 7573 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| DB00796 | 7573 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| DB13919 | 7573 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 158781 | 50940 | 98 | None | - | 0 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 50940 | 98 | None | - | 0 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 158781 | 50940 | 98 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 50940 | 98 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 130881 | 9695 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 9695 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 9695 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 9695 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 9695 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 130881 | 9695 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 9695 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 9695 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 9695 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 9695 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 242 | 7258 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 34 | 7258 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 60795 | 7258 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1112 | 7258 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| DB01238 | 7258 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 216239 | 30567 | 118 | None | - | 7 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200485 | 30567 | 118 | None | - | 7 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1336 | 30567 | 118 | None | - | 7 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| 25181577 | 84994 | 56 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2105695 | 84994 | 56 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 54682461 | 91461 | 62 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL222559 | 91461 | 62 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| 441290 | 21249 | 36 | None | - | 0 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201244 | 21249 | 36 | None | - | 0 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| 65948 | 25328 | 109 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1275868 | 25328 | 109 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| 5077 | 10351 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 7552 | 10351 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 9913767 | 10351 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL238804 | 10351 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| DB11362 | 10351 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 64139 | 91560 | 96 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL223228 | 91560 | 96 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 11173 | 111 | None | - | 4 | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 11173 | 111 | None | - | 4 | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 180 | 7189 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 200 | 7189 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 2160 | 7189 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL629 | 7189 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| DB00321 | 7189 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 3149 | 19386 | 15 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1187011 | 19386 | 15 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 1549120 | 203265 | 85 | None | - | 0 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL56337 | 203265 | 85 | None | - | 0 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5281034 | 21198 | 29 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200585 | 21198 | 29 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| 3599 | 23651 | 88 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL125 | 23651 | 88 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| 5591 | 164310 | 90 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL408 | 164310 | 90 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| 3152 | 195190 | 103 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL502 | 195190 | 103 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| 2333 | 149113 | 97 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL388590 | 149113 | 97 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| 5803 | 169006 | 84 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL41632 | 169006 | 84 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| 104850 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 4150 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 743 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL111 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| DB06155 | 10103 | 96 | None | - | 6 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 11173 | 111 | None | - | 4 | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 11173 | 111 | None | - | 4 | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 5852 | 9395 | 55 | None | - | 4 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 9931891 | 9395 | 55 | None | - | 4 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL239226 | 9395 | 55 | None | - | 4 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 5318 | 22348 | 49 | None | - | 13 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200348 | 22348 | 49 | None | - | 13 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1221 | 22348 | 49 | None | - | 13 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1385580 | 36049 | 76 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 4615 | 36049 | 76 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL13828 | 36049 | 76 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 1056 | 10144 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 2405 | 10144 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 77999 | 10144 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL121 | 10144 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| DB00412 | 10144 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 40973 | 52809 | 70 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1533 | 52809 | 70 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 135409453 | 10545 | 41 | None | - | 2 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 226 | 10545 | 41 | None | - | 2 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| CHEMBL76370 | 10545 | 41 | None | - | 2 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 3516 | 214902 | 100 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| CHEMBL980 | 214902 | 100 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| 135398735 | 143746 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 136262914 | 143746 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL374478 | 143746 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 72093 | 41835 | 9 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1433361 | 41835 | 9 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2103773 | 41835 | 9 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| 4495 | 203314 | 92 | None | - | 29 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL56367 | 203314 | 92 | None | - | 29 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 2303 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 4946 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 564 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 63 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 91536 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL27 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL452861 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00571 | 9961 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 25025298 | 84926 | 39 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2103855 | 84926 | 39 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| 5280453 | 212750 | 74 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL846 | 212750 | 74 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| 54454 | 12030 | 88 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1064 | 12030 | 88 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 6540478 | 21219 | 41 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200934 | 21219 | 41 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 51755 | 64180 | 54 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1651990 | 64180 | 54 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| 1353 | 8692 | 93 | None | -6918 | 85 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 3559 | 8692 | 93 | None | -6918 | 85 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 86 | 8692 | 93 | None | -6918 | 85 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL54 | 8692 | 93 | None | -6918 | 85 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00502 | 8692 | 93 | None | -6918 | 85 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 11980903 | 21264 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 22526 | 21264 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5281035 | 21264 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201303 | 21264 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5564 | 212785 | 118 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL849 | 212785 | 118 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| 3899 | 214553 | 119 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL960 | 214553 | 119 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| 24826799 | 17570 | 104 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1171837 | 17570 | 104 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| 2335 | 18620 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 8478 | 18620 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1182210 | 18620 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL221753 | 18620 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2585 | 7590 | 103 | None | - | 22 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 522 | 7590 | 103 | None | - | 22 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 551 | 7590 | 103 | None | - | 22 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL723 | 7590 | 103 | None | - | 22 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| DB01136 | 7590 | 103 | None | - | 22 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 16220172 | 79818 | 95 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2010601 | 79818 | 95 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| 3926 | 214020 | 40 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL92870 | 214020 | 40 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 54585 | 21274 | 85 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201346 | 21274 | 85 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2812 | 11551 | 101 | None | - | 34 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL104 | 11551 | 101 | None | - | 34 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| 11626560 | 207716 | 94 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL601719 | 207716 | 94 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 47472 | 26209 | 57 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1295 | 26209 | 57 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| 16362 | 9899 | 71 | None | - | 29 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 2172 | 9899 | 71 | None | - | 29 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 90 | 9899 | 71 | None | - | 29 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1423 | 9899 | 71 | None | - | 29 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| DB01100 | 9899 | 71 | None | - | 29 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 392622 | 63086 | 95 | None | - | 4 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL163 | 63086 | 95 | None | - | 4 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
| 4485 | 76154 | 118 | None | - | 8 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| CHEMBL193 | 76154 | 118 | None | - | 8 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| 53232 | 195404 | 95 | None | - | 2 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL503 | 195404 | 95 | None | - | 2 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5329102 | 201505 | 86 | None | - | 0 | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL535 | 201505 | 86 | None | - | 0 | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 2855 | 10904 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 3322 | 10904 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 5717 | 10904 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL603 | 10904 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| DB00549 | 10904 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 3333 | 46942 | 111 | None | - | 1 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1480 | 46942 | 111 | None | - | 1 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 41684 | 37995 | 105 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1401 | 37995 | 105 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| 146015366 | 215181 | 79 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| 60852 | 215181 | 79 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL997 | 215181 | 79 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| 275196 | 132451 | 52 | None | - | 0 | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL364713 | 132451 | 52 | None | - | 0 | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| 4494 | 196966 | 87 | None | - | 0 | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL517427 | 196966 | 87 | None | - | 0 | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| 5282219 | 42643 | 63 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1441961 | 42643 | 63 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| 135565674 | 201623 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 213023 | 201623 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 6445226 | 201623 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 9578572 | 201623 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL539697 | 201623 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 4209 | 9937 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 4893 | 9937 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 503 | 9937 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 5385 | 9937 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2 | 9937 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| DB00457 | 9937 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 5282181 | 60297 | 60 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1601669 | 60297 | 60 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL5314356 | 201376 | 0 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | |||||
| 135564886 | 21265 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 135673376 | 21265 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 137157436 | 21265 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 145948239 | 21265 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 71587099 | 21265 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201304 | 21265 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 2194 | 69857 | 101 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL178862 | 69857 | 101 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 71329 | 186048 | 102 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL473 | 186048 | 102 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| 155540547 | 179300 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4483576 | 179300 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155539027 | 179603 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4514079 | 179603 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155541295 | 179790 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4518318 | 179790 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155547844 | 180477 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4535678 | 180477 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155565112 | 182278 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4577692 | 182278 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155546362 | 180330 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4532075 | 180330 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568289 | 182906 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4592000 | 182906 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155557139 | 181323 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4556070 | 181323 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155520024 | 180025 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524570 | 180025 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155557139 | 181323 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4556070 | 181323 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||||
| 155544988 | 180221 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| CHEMBL4529051 | 180221 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| 155541440 | 179798 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| CHEMBL4518530 | 179798 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| 155540033 | 179669 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| CHEMBL4515768 | 179669 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| 155541125 | 179744 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| CHEMBL4517561 | 179744 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| 155540470 | 179255 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4482867 | 179255 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559120 | 181565 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4561769 | 181565 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155564502 | 182039 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4572408 | 182039 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 54696627 | 105122 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 486 | 5 | 2 | 7 | 5.0 | Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL27511 | 105122 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 486 | 5 | 2 | 7 | 5.0 | Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1016/S0960-894X(01)81134-3 | |||
| 54726669 | 106046 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 461 | 5 | 2 | 6 | 4.6 | O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL281887 | 106046 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 461 | 5 | 2 | 6 | 4.6 | O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 | 10.1016/S0960-894X(01)81134-3 | |||
| 155539027 | 179603 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4514079 | 179603 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547428 | 180394 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4533618 | 180394 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155550799 | 181053 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4549405 | 181053 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155543091 | 179959 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 179959 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155520014 | 180015 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524300 | 180015 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL2028943 | 215914 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| CHEMBL2370909 | 216727 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| 155542907 | 179956 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| CHEMBL4522038 | 179956 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| 155563676 | 182123 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 182123 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL2392353 | 217193 | 6 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 3082475 | 10649 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 6902 | 10649 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4297447 | 10649 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB12199 | 10649 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155568804 | 182899 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 182899 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155541240 | 179795 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4518420 | 179795 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155563538 | 182079 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| CHEMBL4573250 | 182079 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| 155554529 | 181412 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4557984 | 181412 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 10533900 | 182748 | 8 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| CHEMBL4588454 | 182748 | 8 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| 155544246 | 180145 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4527484 | 180145 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553003 | 180855 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4544308 | 180855 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| 155561477 | 181971 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4570840 | 181971 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155562469 | 182000 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| CHEMBL4571382 | 182000 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| 155553930 | 182220 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4576650 | 182220 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155551279 | 180766 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 877 | 29 | 13 | 12 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4542269 | 180766 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 877 | 29 | 13 | 12 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| 3082475 | 10649 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 6902 | 10649 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4297447 | 10649 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB12199 | 10649 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 70538373 | 182277 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4577691 | 182277 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| 155554865 | 181133 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4551317 | 181133 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 54726671 | 101398 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 6 | 5.3 | O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL25226 | 101398 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 6 | 5.3 | O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155560095 | 181701 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4564950 | 181701 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155563538 | 182079 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| CHEMBL4573250 | 182079 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| 155565687 | 182362 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 182362 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155556507 | 181265 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4554466 | 181265 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 54726670 | 100739 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 6.2 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL24842 | 100739 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 6.2 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155560463 | 181819 | 0 | None | - | 0 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| CHEMBL4567667 | 181819 | 0 | None | - | 0 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| 155553003 | 180855 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4544308 | 180855 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| 155554865 | 181133 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4551317 | 181133 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155564502 | 182039 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4572408 | 182039 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155560463 | 181819 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| CHEMBL4567667 | 181819 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| 155551762 | 180789 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4542709 | 180789 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155552995 | 180891 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4545399 | 180891 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155556530 | 181290 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4555119 | 181290 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| 155568109 | 182818 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590381 | 182818 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL2392353 | 217193 | 6 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155556530 | 181290 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4555119 | 181290 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| 11944 | 10648 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155552190 | 10648 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4544228 | 10648 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155540470 | 179255 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4482867 | 179255 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553311 | 180912 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 180912 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 154573825 | 182768 | 9 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4588946 | 182768 | 9 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| 54726676 | 106003 | 0 | None | - | 0 | Bovine | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 501 | 6 | 2 | 7 | 5.3 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL28162 | 106003 | 0 | None | - | 0 | Bovine | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 501 | 6 | 2 | 7 | 5.3 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155540328 | 179680 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| CHEMBL4516066 | 179680 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| 155547428 | 180394 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4533618 | 180394 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 182881 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 182881 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155559827 | 181694 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4564617 | 181694 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155565112 | 182278 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4577692 | 182278 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155558784 | 181555 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4561366 | 181555 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155540639 | 179712 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 179712 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155553479 | 180957 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4547423 | 180957 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155558428 | 181508 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4560224 | 181508 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553479 | 180957 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4547423 | 180957 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155543972 | 181794 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4567103 | 181794 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155567790 | 182832 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590589 | 182832 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155556507 | 181265 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4554466 | 181265 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 130762 | 105023 | 9 | None | - | 0 | Bovine | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Bovine | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155568109 | 182818 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590381 | 182818 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL77838 | 222657 | 5 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | |||||
| 155558428 | 181508 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4560224 | 181508 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155560095 | 181701 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4564950 | 181701 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155548506 | 180533 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4536886 | 180533 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155569246 | 182962 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4593310 | 182962 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155568804 | 182899 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 182899 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155568318 | 182881 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 182881 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155543091 | 179959 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 179959 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155550799 | 181053 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4549405 | 181053 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155540639 | 179712 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 179712 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155544988 | 180221 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| CHEMBL4529051 | 180221 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| 155565687 | 182362 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 182362 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 155563973 | 182140 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 941 | 27 | 14 | 13 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4574655 | 182140 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 941 | 27 | 14 | 13 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155541295 | 179790 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4518318 | 179790 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 145925550 | 182251 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4577270 | 182251 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155539838 | 179674 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 179674 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 11943 | 10647 | 0 | None | - | 1 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 145925549 | 10647 | 0 | None | - | 1 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4438122 | 10647 | 0 | None | - | 1 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155540033 | 179669 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| CHEMBL4515768 | 179669 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| 155520014 | 180015 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524300 | 180015 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL312754 | 217889 | 18 | None | - | 0 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||||
| 155548506 | 180533 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4536886 | 180533 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155548148 | 180494 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4535997 | 180494 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155554529 | 181412 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4557984 | 181412 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155566196 | 182525 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4583284 | 182525 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155558003 | 181472 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4559421 | 181472 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 70538373 | 182277 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4577691 | 182277 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| 154573825 | 182768 | 9 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4588946 | 182768 | 9 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| 155561477 | 181971 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4570840 | 181971 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559104 | 181585 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4562270 | 181585 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155552475 | 180831 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 180831 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155560024 | 181669 | 0 | None | - | 0 | Rat | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4564094 | 181669 | 0 | None | - | 0 | Rat | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 11943 | 10647 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| 145925549 | 10647 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| CHEMBL4438122 | 10647 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| 11943 | 10647 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 145925549 | 10647 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4438122 | 10647 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155542907 | 179956 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| CHEMBL4522038 | 179956 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| 155541125 | 179744 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| CHEMBL4517561 | 179744 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| 155552475 | 180831 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 180831 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155561376 | 182454 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | |||
| CHEMBL4581718 | 182454 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | |||
| 155560024 | 181669 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4564094 | 181669 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155553098 | 180889 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4545153 | 180889 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155553311 | 180912 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 180912 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155540547 | 179300 | 0 | None | - | 0 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4483576 | 179300 | 0 | None | - | 0 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155548148 | 180494 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4535997 | 180494 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155551762 | 180789 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4542709 | 180789 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155546362 | 180330 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4532075 | 180330 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553930 | 182220 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4576650 | 182220 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 54726675 | 106150 | 0 | None | - | 0 | Bovine | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 5.7 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL282566 | 106150 | 0 | None | - | 0 | Bovine | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 5.7 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155558003 | 181472 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4559421 | 181472 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 86727577 | 122754 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 422 | 2 | 1 | 5 | 3.6 | C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 | 10.1021/jm5013006 | |||
| CHEMBL3355127 | 122754 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 422 | 2 | 1 | 5 | 3.6 | C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 | 10.1021/jm5013006 | |||
| 155555310 | 181138 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4551431 | 181138 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155555310 | 181138 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4551431 | 181138 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 10533900 | 182748 | 8 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| CHEMBL4588454 | 182748 | 8 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| 90219582 | 122755 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 436 | 2 | 1 | 5 | 3.9 | Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 | 10.1021/jm5013006 | |||
| CHEMBL3355137 | 122755 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 436 | 2 | 1 | 5 | 3.9 | Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 | 10.1021/jm5013006 | |||
| 155552995 | 180891 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4545399 | 180891 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL77838 | 222657 | 5 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | |||||
| 16133225 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 54726672 | 106083 | 0 | None | - | 0 | Bovine | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 7 | 6.0 | CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL282082 | 106083 | 0 | None | - | 0 | Bovine | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 7 | 6.0 | CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 54726668 | 104020 | 0 | None | - | 0 | Bovine | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 5.3 | O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL26875 | 104020 | 0 | None | - | 0 | Bovine | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 5.3 | O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155559827 | 181694 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4564617 | 181694 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155539838 | 179674 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 179674 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547844 | 180477 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4535678 | 180477 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553098 | 180889 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4545153 | 180889 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155566196 | 182525 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4583284 | 182525 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155567790 | 182832 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590589 | 182832 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155562469 | 182000 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| CHEMBL4571382 | 182000 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| 155568289 | 182906 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4592000 | 182906 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155544246 | 180145 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4527484 | 180145 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155520024 | 180025 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524570 | 180025 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155558784 | 181555 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4561366 | 181555 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155543972 | 181794 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4567103 | 181794 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL938 | 222686 | 28 | None | - | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||||
| 155552886 | 180875 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4544902 | 180875 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155552886 | 180875 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4544902 | 180875 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 145925550 | 182251 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4577270 | 182251 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559104 | 181585 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4562270 | 181585 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155541240 | 179795 | 0 | None | - | 0 | Rat | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4518420 | 179795 | 0 | None | - | 0 | Rat | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL2028943 | 215914 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| 155552429 | 180936 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 180936 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155540328 | 179680 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| CHEMBL4516066 | 179680 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| 155563676 | 182123 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 182123 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155559120 | 181565 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4561769 | 181565 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL2370909 | 216727 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| 155552429 | 180936 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 180936 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL312754 | 217889 | 18 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||||
| 155541440 | 179798 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| CHEMBL4518530 | 179798 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 54726674 | 106506 | 0 | None | - | 0 | Bovine | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 5.9 | CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL284877 | 106506 | 0 | None | - | 0 | Bovine | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 5.9 | CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 | 10.1016/S0960-894X(01)81134-3 | |||
| 11944 | 10648 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155552190 | 10648 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4544228 | 10648 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155558059 | 181462 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4559239 | 181462 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | |||
| 155569246 | 182962 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4593310 | 182962 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 54726673 | 105999 | 0 | None | - | 0 | Bovine | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.8 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL28160 | 105999 | 0 | None | - | 0 | Bovine | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.8 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 10032858 | 36534 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL138690 | 36534 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032858 | 36534 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138690 | 36534 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9895212 | 126418 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL346728 | 126418 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10417251 | 103680 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL265797 | 103680 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417251 | 103680 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL265797 | 103680 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10417251 | 103680 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL265797 | 103680 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10349732 | 125531 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341828 | 125531 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 10032820 | 124082 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339672 | 124082 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10032820 | 124082 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 124082 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10349732 | 125531 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL341828 | 125531 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10032820 | 124082 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339672 | 124082 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10439848 | 125988 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343309 | 125988 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10439848 | 125988 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343309 | 125988 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010071 | 124127 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339722 | 124127 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9829012 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24322 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44311455 | 109521 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305017 | 109521 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311580 | 109556 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305238 | 109556 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311676 | 109838 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307318 | 109838 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311435 | 210801 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69721 | 210801 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311415 | 210864 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70161 | 210864 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311434 | 210903 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70370 | 210903 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311072 | 210965 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70789 | 210965 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311073 | 210979 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70843 | 210979 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311414 | 211002 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70935 | 211002 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9829012 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL24322 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 73347893 | 99401 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435828 | 99401 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9829012 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24322 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19754061 | 109511 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304947 | 109511 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 44309719 | 210633 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68638 | 210633 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10010071 | 124127 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 124127 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9829012 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24322 | 99331 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 9829012 | 99331 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| CHEMBL24322 | 99331 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| 9809961 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL316300 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10439862 | 125550 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341934 | 125550 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10010195 | 125962 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343142 | 125962 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 9809961 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316300 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9917295 | 109735 | 17 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306407 | 109735 | 17 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9809961 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316300 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 9809961 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL316300 | 113938 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10439862 | 125550 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341934 | 125550 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010195 | 125962 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343142 | 125962 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10395394 | 38654 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL140708 | 38654 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032851 | 23607 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL124771 | 23607 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9809637 | 210631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68618 | 210631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10032851 | 23607 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 23607 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395394 | 38654 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL140708 | 38654 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210588 | 127123 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353037 | 127123 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032851 | 23607 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL124771 | 23607 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10327309 | 120668 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332576 | 120668 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1007/s00044-011-9815-x | |||
| 10395335 | 123860 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339256 | 123860 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10372451 | 124072 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339605 | 124072 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10327309 | 120668 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332576 | 120668 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| 10395335 | 123860 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 123860 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10372451 | 124072 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 124072 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10372093 | 119539 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330533 | 119539 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| 44314822 | 109726 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 109726 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10259411 | 37431 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139452 | 37431 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10485116 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL338101 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 10462598 | 120913 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332909 | 120913 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| 10485116 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338101 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10395076 | 175355 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL435811 | 175355 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462598 | 120913 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 120913 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10485116 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338101 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10395076 | 175355 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 175355 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395076 | 175355 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 175355 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259411 | 37431 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139452 | 37431 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10485116 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL338101 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10462598 | 120913 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332909 | 120913 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| 10485116 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338101 | 123631 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10395076 | 175355 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL435811 | 175355 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19939453 | 119168 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL329679 | 119168 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10326797 | 214353 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94905 | 214353 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 44381724 | 127086 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352771 | 127086 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381671 | 127205 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353800 | 127205 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10259395 | 33768 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL136465 | 33768 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10078663 | 214566 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL96075 | 214566 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 9853391 | 123617 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338027 | 123617 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101608 | 123807 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339004 | 123807 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10078663 | 214566 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96075 | 214566 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9853391 | 123617 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 123617 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101608 | 123807 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 123807 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10009273 | 114002 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316706 | 114002 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10259395 | 33768 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL136465 | 33768 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10078663 | 214566 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL96075 | 214566 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 44327716 | 114091 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL317343 | 114091 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 9853391 | 123617 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338027 | 123617 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101608 | 123807 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339004 | 123807 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101284 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL93907 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10372659 | 124868 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL340632 | 124868 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101284 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL93907 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| 54693559 | 211319 | 2 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 425 | 4 | 2 | 8 | 3.0 | Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1021/jm0204237 | |||
| CHEMBL72838 | 211319 | 2 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 425 | 4 | 2 | 8 | 3.0 | Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1021/jm0204237 | |||
| 10101284 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL93907 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10372659 | 124868 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 124868 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101284 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL93907 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| 10417351 | 214737 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97075 | 214737 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 44327912 | 214914 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| CHEMBL98068 | 214914 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| 10101284 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL93907 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381413 | 127500 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354779 | 127500 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101284 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL93907 | 214181 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| 10372659 | 124868 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL340632 | 124868 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10327537 | 123455 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL337118 | 123455 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10327537 | 123455 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337118 | 123455 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210586 | 65786 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169221 | 65786 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381527 | 65848 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169568 | 65848 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10462933 | 23654 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125008 | 23654 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 76333473 | 91680 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL2236976 | 91680 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10462933 | 23654 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 23654 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44348523 | 119956 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 119956 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10078397 | 18881 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1184032 | 18881 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329290 | 18881 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 44315351 | 111662 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 111662 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44314823 | 168665 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 168665 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44381427 | 127051 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352503 | 127051 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10462933 | 23654 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125008 | 23654 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 76333473 | 91680 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL2236976 | 91680 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10439837 | 23125 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122917 | 23125 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462683 | 120059 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331507 | 120059 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44311289 | 109002 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302964 | 109002 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311456 | 109075 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303427 | 109075 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311715 | 109973 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308323 | 109973 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311074 | 111677 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311253 | 111677 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311412 | 112106 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311625 | 112106 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311581 | 174612 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL430792 | 174612 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311582 | 210987 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70868 | 210987 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9918412 | 211041 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71172 | 211041 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311413 | 211130 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71639 | 211130 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311753 | 211390 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73283 | 211390 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 133031 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL293511 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 19939756 | 11810 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL105199 | 11810 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL293511 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 44335530 | 114286 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL318605 | 114286 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL293511 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| 10439837 | 23125 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 23125 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462683 | 120059 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 120059 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44377058 | 126784 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350121 | 126784 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349512 | 214786 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97332 | 214786 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44314761 | 109631 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 109631 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9853391 | 123617 | 1 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| CHEMBL338027 | 123617 | 1 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| 133031 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL293511 | 107636 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10439837 | 23125 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122917 | 23125 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462683 | 120059 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331507 | 120059 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10010234 | 105203 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL275552 | 105203 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10100951 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL334300 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9987614 | 175352 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL435792 | 175352 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10100951 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL334300 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10259468 | 125259 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL341369 | 125259 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10390872 | 122924 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL335778 | 122924 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| 10100951 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10259468 | 125259 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 125259 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9895635 | 118800 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328941 | 118800 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010234 | 105203 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL275552 | 105203 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10100951 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL334300 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 9987614 | 175352 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL435792 | 175352 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381402 | 65939 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169967 | 65939 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10100951 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL334300 | 121822 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10259468 | 125259 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL341369 | 125259 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101606 | 22543 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122273 | 22543 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259447 | 23700 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125280 | 23700 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| 10101606 | 22543 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 22543 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259447 | 23700 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 23700 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 10326942 | 119171 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329693 | 119171 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| 10417102 | 214225 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94145 | 214225 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 10101606 | 22543 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122273 | 22543 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259447 | 23700 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125280 | 23700 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| 10033136 | 22845 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122380 | 22845 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10033136 | 22845 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 22845 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315078 | 211535 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 211535 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10033136 | 22845 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122380 | 22845 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10009984 | 119957 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331455 | 119957 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440144 | 123672 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338342 | 123672 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10009984 | 119957 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 119957 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10440144 | 123672 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 123672 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292113 | 102808 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 102808 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 211528 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 211528 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 211528 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL74476 | 211528 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| 44381657 | 65832 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169488 | 65832 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9895984 | 211528 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL74476 | 211528 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10009984 | 119957 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331455 | 119957 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440144 | 123672 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338342 | 123672 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10372497 | 125524 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341783 | 125524 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10259657 | 126171 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344597 | 126171 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10259489 | 23690 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1007/s00044-011-9815-x | |||
| CHEMBL125231 | 23690 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1007/s00044-011-9815-x | |||
| 19939418 | 115047 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL319730 | 115047 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10395335 | 123860 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 123860 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10259489 | 23690 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| CHEMBL125231 | 23690 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| 10372497 | 125524 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341783 | 125524 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10259657 | 126171 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344597 | 126171 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210589 | 65370 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168413 | 65370 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381403 | 65940 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169968 | 65940 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44210585 | 127185 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353615 | 127185 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10010207 | 36968 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139041 | 36968 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10078780 | 123694 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338433 | 123694 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10439819 | 176668 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL444065 | 176668 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19754068 | 109510 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304946 | 109510 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10078780 | 123694 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 123694 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10439819 | 176668 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 176668 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10416475 | 214483 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95579 | 214483 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| 10010207 | 36968 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139041 | 36968 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210590 | 65488 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168490 | 65488 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10439715 | 123813 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339040 | 123813 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44309938 | 211079 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71388 | 211079 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10028545 | 27777 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL131156 | 27777 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| 10439715 | 123813 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 123813 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10055534 | 164240 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL407919 | 164240 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9875044 | 214808 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97446 | 214808 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10439715 | 123813 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339040 | 123813 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 11765560 | 22309 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121872 | 22309 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9987414 | 123827 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339113 | 123827 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19430442 | 210954 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70726 | 210954 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 11765560 | 22309 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 22309 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9987414 | 123827 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 123827 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10100951 | 121822 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 121822 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 11765560 | 22309 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121872 | 22309 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9987414 | 123827 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339113 | 123827 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9810305 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9810305 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 9810305 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9810305 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 9810305 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 9810305 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10439993 | 126034 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343634 | 126034 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44311675 | 108931 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302579 | 108931 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311537 | 109109 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303647 | 109109 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311454 | 109722 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306340 | 109722 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311185 | 110968 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309790 | 110968 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311752 | 111642 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311018 | 111642 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311736 | 210986 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70867 | 210986 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311557 | 211062 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71286 | 211062 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73353934 | 99397 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435824 | 99397 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | |||
| 10326972 | 119038 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329099 | 119038 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 133031 | 107636 | 21 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293511 | 107636 | 21 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44300826 | 205517 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58291 | 205517 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44372744 | 58925 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| CHEMBL158795 | 58925 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| 9807029 | 209883 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL63998 | 209883 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a001 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a001 | |||
| 44384389 | 136615 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367569 | 136615 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10439993 | 126034 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343634 | 126034 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 19102786 | 213968 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL92533 | 213968 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10032583 | 19121 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1185398 | 19121 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL411487 | 19121 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| 10054708 | 113931 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316273 | 113931 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 10462598 | 120913 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 120913 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10032820 | 124082 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 124082 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44381552 | 127065 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352629 | 127065 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9917399 | 108923 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302519 | 108923 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 9917399 | 108923 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| CHEMBL302519 | 108923 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 44381553 | 127114 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352947 | 127114 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 136052288 | 131262 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 568 | 8 | 1 | 8 | 5.2 | CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640122 | 131262 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 568 | 8 | 1 | 8 | 5.2 | CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10101351 | 175443 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 175443 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 71652854 | 95931 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337686 | 95931 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366020 | 95931 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 10101351 | 175443 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL436396 | 175443 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19430462 | 109761 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306638 | 109761 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||||
| 14971698 | 214072 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| CHEMBL93226 | 214072 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| 10101351 | 175443 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 175443 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032342 | 214801 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97394 | 214801 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 44381426 | 127050 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352502 | 127050 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101351 | 175443 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL436396 | 175443 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10373120 | 124379 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340078 | 124379 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10373120 | 124379 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 124379 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 19939398 | 114111 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317547 | 114111 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10372718 | 115334 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| CHEMBL320222 | 115334 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| 10259447 | 23700 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 23700 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 44381656 | 127046 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352458 | 127046 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10373120 | 124379 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340078 | 124379 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440203 | 125765 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342492 | 125765 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 11765454 | 124846 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340473 | 124846 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44310069 | 210517 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67801 | 210517 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11765454 | 124846 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 124846 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349597 | 118395 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328434 | 118395 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| 10440203 | 125765 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342492 | 125765 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 11765454 | 124846 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340473 | 124846 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10259525 | 22391 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122158 | 22391 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10349897 | 121205 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL333224 | 121205 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101690 | 123639 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338137 | 123639 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10010071 | 124127 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 124127 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 22391 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 22391 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349897 | 121205 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 121205 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101690 | 123639 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 123639 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 22391 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122158 | 22391 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10349897 | 121205 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL333224 | 121205 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101690 | 123639 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338137 | 123639 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44328276 | 119504 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330464 | 119504 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 44381622 | 65795 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169279 | 65795 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44311619 | 109847 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307359 | 109847 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311683 | 112395 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL312301 | 112395 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311453 | 210816 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69839 | 210816 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 16133225 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 172198 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 2504 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 45266664 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 5272 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| CHEMBL408403 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| DB11842 | 7207 | 52 | None | -2 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 183134 | 211623 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 73347892 | 99396 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435823 | 99396 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 183134 | 211623 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.03.006 | |||||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.11.014 | |||||
| 10394995 | 118171 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327191 | 118171 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| 10326775 | 119016 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329089 | 119016 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| 10010047 | 214730 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97020 | 214730 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10439819 | 176668 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 176668 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44384870 | 66820 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173643 | 66820 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10010311 | 37300 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139325 | 37300 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417144 | 39754 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL141592 | 39754 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10462573 | 123787 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338889 | 123787 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032988 | 123695 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 123695 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462573 | 123787 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 123787 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10078132 | 114028 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316904 | 114028 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| 10010311 | 37300 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139325 | 37300 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10417144 | 39754 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL141592 | 39754 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10462573 | 123787 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338889 | 123787 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 11765541 | 125786 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342605 | 125786 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032988 | 123695 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338434 | 123695 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032988 | 123695 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 123695 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10077743 | 214736 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97068 | 214736 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 11765541 | 125786 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342605 | 125786 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10032988 | 123695 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338434 | 123695 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10349659 | 118320 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327988 | 118320 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| 10395335 | 123860 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 123860 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10259468 | 125259 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 125259 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| 9852499 | 127241 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354080 | 127241 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032877 | 22321 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121907 | 22321 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259841 | 22930 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122401 | 22930 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9827346 | 106513 | 4 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL284918 | 106513 | 4 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL34866 | 106513 | 4 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 10032877 | 22321 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 22321 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259841 | 22930 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 22930 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372451 | 124072 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 124072 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032877 | 22321 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121907 | 22321 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259841 | 22930 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122401 | 22930 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9830680 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL292150 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9830680 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL292150 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9830680 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL292150 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10009984 | 119957 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 119957 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9830680 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| CHEMBL292150 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| 9830680 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL292150 | 107419 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 44312565 | 211550 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| CHEMBL74767 | 211550 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| 44348153 | 124748 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL340367 | 124748 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 72548703 | 168346 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 168346 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| 10009968 | 119324 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329942 | 119324 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 10480309 | 23150 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122969 | 23150 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10007362 | 24089 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125725 | 24089 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311182 | 109804 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307008 | 109804 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311452 | 211284 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72595 | 211284 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9940350 | 211537 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74573 | 211537 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44275095 | 101952 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25585 | 101952 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44309704 | 211057 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71253 | 211057 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44379268 | 126832 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL350554 | 126832 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44377125 | 62413 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162148 | 62413 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10032851 | 23607 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 23607 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 11765177 | 123786 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338888 | 123786 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 19939753 | 210533 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67921 | 210533 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11765177 | 123786 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 123786 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11765177 | 123786 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338888 | 123786 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 44315144 | 103367 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 103367 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10439858 | 23633 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL124903 | 23633 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 18950609 | 23177 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| CHEMBL123084 | 23177 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| 10439858 | 23633 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 23633 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439858 | 23633 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL124903 | 23633 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a033 | |||
| 44315282 | 103399 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 103399 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 14971639 | 120909 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| CHEMBL332897 | 120909 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| 9939191 | 105722 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10101608 | 123807 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 123807 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44381425 | 127232 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353980 | 127232 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032193 | 125923 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342843 | 125923 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10394829 | 126138 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344387 | 126138 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417321 | 22390 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122157 | 22390 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10417321 | 22390 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 22390 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10438745 | 113993 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316655 | 113993 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| 10258694 | 119364 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330165 | 119364 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010071 | 124127 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 124127 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032193 | 125923 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342843 | 125923 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10394829 | 126138 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344387 | 126138 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10417321 | 22390 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122157 | 22390 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 19430475 | 211031 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71125 | 211031 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9874508 | 211459 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 211459 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9874508 | 211459 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| CHEMBL73876 | 211459 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2010.07.034 | |||||
| 44274855 | 103717 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 564 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26614 | 103717 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 564 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9960852 | 113959 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316482 | 113959 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 10030110 | 23022 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122443 | 23022 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10256602 | 23638 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124925 | 23638 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10052399 | 125246 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341295 | 125246 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311617 | 109316 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL304065 | 109316 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311618 | 170116 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL419073 | 170116 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 19430479 | 211048 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71220 | 211048 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311184 | 211200 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72099 | 211200 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311558 | 211501 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74236 | 211501 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2013.03.016 | |||||
| 44309902 | 109894 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL307757 | 109894 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44309703 | 179333 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL448476 | 179333 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44309903 | 211173 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71925 | 211173 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10010027 | 214811 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97465 | 214811 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44309903 | 211173 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL71925 | 211173 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10372810 | 112979 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 112979 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 15292111 | 211524 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 211524 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10485202 | 126198 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344811 | 126198 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10485202 | 126198 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344811 | 126198 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 1952 | 8990 | 4 | None | - | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 5312129 | 8990 | 4 | None | - | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| CHEMBL1182768 | 8990 | 4 | None | - | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 9874086 | 115890 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321367 | 115890 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10439715 | 123813 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 123813 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10457566 | 209581 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62269 | 209581 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44282952 | 127207 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL35381 | 127207 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| 10350378 | 214978 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98453 | 214978 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10028460 | 123299 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL336180 | 123299 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| 10009478 | 119249 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329858 | 119249 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10414338 | 24736 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126111 | 24736 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9824776 | 126143 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL344407 | 126143 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 60148656 | 99402 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435829 | 99402 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9824776 | 126143 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL344407 | 126143 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 15292113 | 102808 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 102808 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10349801 | 114715 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319353 | 114715 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10417431 | 115885 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321363 | 115885 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10101606 | 22543 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 22543 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 15292112 | 109725 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 109725 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 14956763 | 170176 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL419483 | 170176 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 19430458 | 210853 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70100 | 210853 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 18950608 | 22443 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122224 | 22443 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| 10032361 | 119503 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330463 | 119503 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| 9987414 | 123827 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 123827 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44275095 | 101952 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25585 | 101952 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 18950586 | 22336 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122017 | 22336 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| 9986299 | 165230 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL409058 | 165230 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| 10349392 | 214829 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97557 | 214829 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10372659 | 124868 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 124868 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 135955119 | 131269 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640129 | 131269 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 53321879 | 64371 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1667998 | 64371 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44315304 | 211789 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 211789 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 73349224 | 98968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 11 | 4.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL2425239 | 98968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 11 | 4.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 | 10.1007/s00044-013-0831-x | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| 44311538 | 109740 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306435 | 109740 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311183 | 211479 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74069 | 211479 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311735 | 211531 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74514 | 211531 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 15076146 | 113753 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL315104 | 113753 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 9914666 | 123448 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL337086 | 123448 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | |||
| 44272246 | 105565 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 628 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278305 | 105565 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 628 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44272247 | 105639 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278977 | 105639 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15076146 | 113753 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL315104 | 113753 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44310586 | 179426 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL449648 | 179426 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 10483888 | 118232 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327563 | 118232 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| 10416501 | 119187 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329759 | 119187 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10483726 | 214355 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94910 | 214355 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9961192 | 18138 | 43 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179743 | 18138 | 43 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97688 | 18138 | 43 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 123746 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338687 | 123746 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10078554 | 123746 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 123746 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10010125 | 214810 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97464 | 214810 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 123746 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338687 | 123746 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 44275096 | 101530 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25315 | 101530 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10259265 | 116820 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 116820 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10259265 | 116820 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL323506 | 116820 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10077497 | 18141 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179757 | 18141 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98426 | 18141 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| 11765560 | 22309 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 22309 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314761 | 109631 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 109631 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10394712 | 126155 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344467 | 126155 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 14956739 | 213081 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87074 | 213081 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10394712 | 126155 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344467 | 126155 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381528 | 65767 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169009 | 65767 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032877 | 22321 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 22321 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314823 | 168665 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 168665 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10484866 | 38559 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL140619 | 38559 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 9984181 | 125226 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341131 | 125226 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277573 | 106317 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL283495 | 106317 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277871 | 106476 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28464 | 106476 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 192626 | 22431 | 14 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| CHEMBL122212 | 22431 | 14 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| 1481 | 8847 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 3749 | 8847 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 589 | 8847 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 6908 | 8847 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL1513 | 8847 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| DB01029 | 8847 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 44285267 | 155227 | 33 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.4 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39379 | 155227 | 33 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.4 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44274731 | 106843 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287184 | 106843 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 70682146 | 83106 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058860 | 83106 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10078800 | 115968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 115968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44311635 | 109001 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302959 | 109001 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| 10032988 | 123695 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 123695 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44385182 | 67848 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL176473 | 67848 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10484866 | 38559 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL140619 | 38559 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10372550 | 171295 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL421478 | 171295 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10372550 | 171295 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 171295 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372550 | 171295 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL421478 | 171295 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 145946921 | 174379 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337687 | 174379 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337688 | 174379 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL4300967 | 174379 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44314780 | 109855 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 109855 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 14956772 | 112724 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL312913 | 112724 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9830839 | 113708 | 0 | None | - | 2 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314812 | 113708 | 0 | None | - | 2 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| 10078780 | 123694 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 123694 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10373120 | 124379 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 124379 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44381739 | 65559 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168771 | 65559 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44274854 | 101092 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.1 | CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25056 | 101092 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.1 | CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274731 | 106843 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287184 | 106843 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10055448 | 37536 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139582 | 37536 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 136052335 | 131265 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 622 | 8 | 1 | 8 | 5.8 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| CHEMBL3640125 | 131265 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 622 | 8 | 1 | 8 | 5.8 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| 136052364 | 131268 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 608 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640128 | 131268 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 608 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 135876075 | 131271 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 624 | 9 | 1 | 11 | 5.6 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 | nan | |||
| CHEMBL3640131 | 131271 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 624 | 9 | 1 | 11 | 5.6 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 | nan | |||
| 11755602 | 175226 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 497 | 9 | 1 | 9 | 3.6 | CCCCc1nc2ccn(CC(=O)OC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL43500 | 175226 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 497 | 9 | 1 | 9 | 3.6 | CCCCc1nc2ccn(CC(=O)OC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 44311754 | 109774 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306761 | 109774 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311071 | 110192 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308482 | 110192 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 3036053 | 108110 | 13 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL296725 | 108110 | 13 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 10322211 | 176251 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL442963 | 176251 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | |||
| 15818748 | 106689 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL286134 | 106689 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 9850811 | 161519 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39996 | 161519 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 19939454 | 214336 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL94793 | 214336 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 3036053 | 108110 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL296725 | 108110 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| 3036053 | 108110 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL296725 | 108110 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 44289008 | 171643 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL42200 | 171643 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10417031 | 114163 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317864 | 114163 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10439253 | 119098 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329255 | 119098 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| 10439837 | 23125 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 23125 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44348523 | 119956 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 119956 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462683 | 120059 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 120059 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9851082 | 107797 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL294512 | 107797 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 44381739 | 65559 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL168771 | 65559 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm701575k | |||||
| 10055448 | 37536 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139582 | 37536 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 1037 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 588 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 14952924 | 204709 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL57309 | 204709 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1 | 10.1016/S0960-894X(01)81116-1 | |||
| 136052282 | 131266 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 8 | 1 | 9 | 5.2 | O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 | nan | |||
| CHEMBL3640126 | 131266 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 8 | 1 | 9 | 5.2 | O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 | nan | |||
| 136052259 | 131272 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 | nan | |||
| CHEMBL3640132 | 131272 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 | nan | |||
| 44277676 | 106095 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 613 | 11 | 0 | 9 | 6.1 | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282167 | 106095 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 613 | 11 | 0 | 9 | 6.1 | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10028209 | 108194 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 482 | 9 | 2 | 8 | 2.9 | CCCCc1nc2ccn(CC(N)=O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL297358 | 108194 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 482 | 9 | 2 | 8 | 2.9 | CCCCc1nc2ccn(CC(N)=O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 3936 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 6603900 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL288174 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 44274692 | 103221 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26217 | 103221 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9955424 | 171903 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422756 | 171903 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127034873 | 143227 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735744 | 143227 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44379183 | 127593 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355708 | 127593 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10461785 | 18695 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1182712 | 18695 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL262296 | 18695 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| 10348847 | 119366 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330170 | 119366 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10484119 | 174887 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432822 | 174887 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10054188 | 214300 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94582 | 214300 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10462933 | 23654 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 23654 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 3936 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 6603900 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| CHEMBL288174 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 44381670 | 127262 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354298 | 127262 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10392378 | 23290 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123671 | 23290 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325267 | 23635 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 550 | 12 | 1 | 9 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124913 | 23635 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 550 | 12 | 1 | 9 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052261 | 131264 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 618 | 8 | 1 | 8 | 5.9 | Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 | nan | |||
| CHEMBL3640124 | 131264 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 618 | 8 | 1 | 8 | 5.9 | Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 | nan | |||
| 136052281 | 131270 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O | nan | |||
| CHEMBL3640130 | 131270 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O | nan | |||
| 136052251 | 131281 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 7 | 1 | 9 | 4.5 | CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640140 | 131281 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 7 | 1 | 9 | 4.5 | CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052396 | 131299 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 610 | 6 | 1 | 9 | 5.7 | CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640158 | 131299 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 610 | 6 | 1 | 9 | 5.7 | CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052283 | 131300 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 7 | 1 | 9 | 4.8 | CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640159 | 131300 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 7 | 1 | 9 | 4.8 | CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 44277677 | 106096 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282168 | 106096 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 18950598 | 22314 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| CHEMBL121891 | 22314 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| 73355475 | 99400 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435827 | 99400 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 14956779 | 75438 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL19202 | 75438 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10078048 | 113657 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314514 | 113657 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 9986951 | 214546 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95955 | 214546 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44314822 | 109726 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 109726 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315058 | 77228 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 77228 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9869504 | 214826 | 4 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 214826 | 4 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 44274673 | 100515 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24724 | 100515 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10254585 | 119681 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331042 | 119681 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052277 | 131294 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 656 | 10 | 1 | 11 | 5.3 | CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640153 | 131294 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 656 | 10 | 1 | 11 | 5.3 | CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 137662335 | 167614 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 593 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL4114708 | 167614 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 593 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44277902 | 106570 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28532 | 106570 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44274673 | 100515 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24724 | 100515 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 1481 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 3749 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 589 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 6908 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| CHEMBL1513 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| DB01029 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 22574723 | 22710 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 7 | 5.2 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 | 10.1039/C4MD00499J | |||
| CHEMBL12233 | 22710 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 7 | 5.2 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 | 10.1039/C4MD00499J | |||
| 57380647 | 77129 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945010 | 77129 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 70686410 | 83105 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058859 | 83105 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 19939409 | 113937 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316299 | 113937 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 1481 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 3749 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 589 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 6908 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL1513 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| DB01029 | 8847 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 10372341 | 174977 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL433375 | 174977 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| 10077929 | 214124 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93606 | 214124 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| 10326460 | 214886 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97897 | 214886 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10009735 | 164984 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408798 | 164984 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 76311803 | 91745 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 12 | 3 | 11 | 4.6 | CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237602 | 91745 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 12 | 3 | 11 | 4.6 | CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9987311 | 123535 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL337588 | 123535 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10414470 | 23901 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125542 | 23901 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44320012 | 174702 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL431411 | 174702 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052301 | 131273 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 9 | 1 | 11 | 5.2 | CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 | nan | |||
| CHEMBL3640133 | 131273 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 9 | 1 | 11 | 5.2 | CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 | nan | |||
| 136052255 | 131277 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 684 | 9 | 1 | 10 | 5.6 | COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| CHEMBL3640137 | 131277 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 684 | 9 | 1 | 10 | 5.6 | COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| 136052247 | 131287 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 4.6 | CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640146 | 131287 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 4.6 | CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 136052300 | 131296 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640155 | 131296 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 | nan | |||
| 136052332 | 131304 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640162 | 131304 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052372 | 131308 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640166 | 131308 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052324 | 131310 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 8 | 1 | 10 | 4.8 | CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640171 | 131310 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 8 | 1 | 10 | 4.8 | CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10481968 | 57468 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL157577 | 57468 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 15236320 | 179385 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL449095 | 179385 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 10054324 | 105129 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL275160 | 105129 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10099040 | 127019 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 10 | 5.0 | CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL352236 | 127019 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 10 | 5.0 | CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9852384 | 107192 | 5 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL290214 | 107192 | 5 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.9b01780 | |||
| 127035265 | 143314 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736514 | 143314 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10417195 | 115856 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 115856 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10054324 | 105129 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL275160 | 105129 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10101690 | 123639 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 123639 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9852384 | 107192 | 5 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL290214 | 107192 | 5 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 44305410 | 169138 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL416507 | 169138 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 9987311 | 123535 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337588 | 123535 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10321941 | 144925 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL37679 | 144925 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 19010048 | 91743 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237600 | 91743 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10327728 | 104898 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL273542 | 104898 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10369867 | 23149 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122966 | 23149 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 135876074 | 131267 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640127 | 131267 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052291 | 131283 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 | nan | |||
| CHEMBL3640142 | 131283 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 | nan | |||
| 136052286 | 131284 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 8 | 1 | 9 | 5.5 | O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 | nan | |||
| CHEMBL3640143 | 131284 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 8 | 1 | 9 | 5.5 | O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 | nan | |||
| 136052352 | 131286 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 8 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640145 | 131286 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 8 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052270 | 131290 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 10 | 1 | 11 | 4.0 | CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640149 | 131290 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 10 | 1 | 11 | 4.0 | CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052397 | 131292 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 1 | 10 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640151 | 131292 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 1 | 10 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052320 | 131293 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 9 | 2 | 10 | 4.7 | CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640152 | 131293 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 9 | 2 | 10 | 4.7 | CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052319 | 131305 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640163 | 131305 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052299 | 131307 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 570 | 8 | 1 | 9 | 5.0 | CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640165 | 131307 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 570 | 8 | 1 | 9 | 5.0 | CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 10481968 | 57468 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157577 | 57468 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9850834 | 161441 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 44379292 | 127112 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352934 | 127112 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10327728 | 104898 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 104898 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10438523 | 214923 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98126 | 214923 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 11765454 | 124846 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 124846 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315144 | 103367 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 103367 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44300838 | 205449 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57976 | 205449 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9850834 | 161441 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 44211672 | 164985 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408799 | 164985 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10327728 | 104898 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL273542 | 104898 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10484986 | 125475 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341715 | 125475 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 136052375 | 131263 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 638 | 8 | 1 | 8 | 6.3 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| CHEMBL3640123 | 131263 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 638 | 8 | 1 | 8 | 6.3 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| 136052302 | 131278 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| CHEMBL3640138 | 131278 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| 136052246 | 131279 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 9 | 1 | 10 | 5.2 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640139 | 131279 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 9 | 1 | 10 | 5.2 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 136052258 | 131298 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.8 | CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640157 | 131298 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.8 | CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052298 | 131309 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 11 | 1 | 11 | 5.3 | CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| CHEMBL3640167 | 131309 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 11 | 1 | 11 | 5.3 | CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| 136052297 | 131312 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 578 | 8 | 1 | 8 | 5.8 | CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640173 | 131312 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 578 | 8 | 1 | 8 | 5.8 | CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 | nan | |||
| 44277903 | 105894 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 10 | 0 | 9 | 5.0 | CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280908 | 105894 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 10 | 0 | 9 | 5.0 | CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 11764826 | 105060 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL274710 | 105060 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15231091 | 100763 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24861 | 100763 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274823 | 105851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL280526 | 105851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 45102750 | 70552 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL1801740 | 70552 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 45102750 | 70552 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801740 | 70552 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 19754050 | 210659 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68786 | 210659 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11764826 | 105060 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274710 | 105060 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10233056 | 113936 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316297 | 113936 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| 10259525 | 22391 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 22391 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259841 | 22930 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 22930 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315351 | 111662 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 111662 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10484986 | 125475 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341715 | 125475 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10030086 | 23749 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125383 | 23749 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052394 | 131276 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640136 | 131276 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052399 | 131282 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 622 | 8 | 1 | 9 | 5.6 | CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640141 | 131282 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 622 | 8 | 1 | 9 | 5.6 | CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052347 | 131285 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 618 | 8 | 1 | 11 | 4.6 | CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640144 | 131285 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 618 | 8 | 1 | 11 | 4.6 | CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052345 | 131288 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 9 | 3.9 | CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640147 | 131288 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 9 | 3.9 | CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052268 | 131289 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 560 | 7 | 2 | 10 | 3.4 | CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640148 | 131289 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 560 | 7 | 2 | 10 | 3.4 | CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052310 | 131297 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 626 | 10 | 1 | 10 | 5.3 | CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640156 | 131297 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 626 | 10 | 1 | 10 | 5.3 | CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052379 | 131303 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 672 | 9 | 1 | 11 | 5.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 | nan | |||
| CHEMBL3640161 | 131303 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 672 | 9 | 1 | 11 | 5.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 | nan | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277573 | 106317 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL283495 | 106317 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277442 | 107073 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28917 | 107073 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277451 | 107683 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 601 | 10 | 0 | 8 | 6.3 | CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29386 | 107683 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 601 | 10 | 0 | 8 | 6.3 | CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44283174 | 106850 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL287250 | 106850 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44310589 | 174877 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL432734 | 174877 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| 44377199 | 64193 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165349 | 64193 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| 9801006 | 126507 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1021/jm9504722 | |||
| CHEMBL347610 | 126507 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1021/jm9504722 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| 9851889 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00052a006 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00052a006 | |||
| 10258916 | 36484 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL138654 | 36484 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 10010164 | 124175 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339806 | 124175 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9845644 | 213212 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87964 | 213212 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052351 | 131274 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 608 | 9 | 1 | 11 | 5.5 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 | nan | |||
| CHEMBL3640134 | 131274 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 608 | 9 | 1 | 11 | 5.5 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 | nan | |||
| 136052241 | 131275 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 3.3 | CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640135 | 131275 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 3.3 | CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052269 | 131291 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 7 | 2 | 9 | 4.3 | CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640150 | 131291 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 7 | 2 | 9 | 4.3 | CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052400 | 131306 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640164 | 131306 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136401533 | 167620 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 649 | 12 | 1 | 11 | 5.5 | C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| CHEMBL4114807 | 167620 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 649 | 12 | 1 | 11 | 5.5 | C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| 108185 | 8395 | 78 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00037a014 | |||
| 586 | 8395 | 78 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00037a014 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00037a014 | |||
| 10010164 | 124175 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 124175 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10100074 | 119337 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330007 | 119337 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9810305 | 105348 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 105348 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10258916 | 36484 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138654 | 36484 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 10010164 | 124175 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339806 | 124175 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10394859 | 24201 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL125760 | 24201 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9960721 | 23083 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 12 | 0 | 8 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122638 | 23083 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 12 | 0 | 8 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 59351471 | 131295 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 417 | 5 | 1 | 6 | 3.9 | CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 | nan | |||
| CHEMBL3640154 | 131295 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 417 | 5 | 1 | 6 | 3.9 | CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 | nan | |||
| 136052367 | 131311 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 648 | 8 | 1 | 10 | 5.6 | CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640172 | 131311 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 648 | 8 | 1 | 10 | 5.6 | CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44277652 | 106600 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 8 | 0 | 8 | 5.5 | CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28555 | 106600 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 8 | 0 | 8 | 5.5 | CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 2806 | 10741 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 3937 | 10741 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 593 | 10741 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 60846 | 10741 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| DB00177 | 10741 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 10394859 | 24201 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 24201 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44376746 | 126637 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL348758 | 126637 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10033136 | 22845 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 22845 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315078 | 211535 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 211535 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44303230 | 207426 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL59957 | 207426 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10394859 | 24201 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL125760 | 24201 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 76308179 | 91750 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 584 | 12 | 3 | 9 | 4.1 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237607 | 91750 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 584 | 12 | 3 | 9 | 4.1 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10222835 | 212924 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86084 | 212924 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44459556 | 105507 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL277902 | 105507 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 19087866 | 105712 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL279515 | 105712 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44459544 | 106145 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL282526 | 106145 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311428 | 109746 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306473 | 109746 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311543 | 110918 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309455 | 110918 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10069786 | 175880 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL439968 | 175880 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19008869 | 213193 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| CHEMBL87842 | 213193 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| 10325037 | 126565 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 541 | 11 | 2 | 8 | 4.5 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348143 | 126565 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 541 | 11 | 2 | 8 | 4.5 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73353933 | 99394 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435821 | 99394 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 70696780 | 82995 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058374 | 82995 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 19102815 | 214657 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 214657 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44311342 | 108958 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302760 | 108958 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311450 | 110878 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309365 | 110878 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311688 | 110973 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309820 | 110973 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222101 | 165341 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL409170 | 165341 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311664 | 210942 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70638 | 210942 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311449 | 211259 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 3.9 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72409 | 211259 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 3.9 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15292111 | 211524 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 211524 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10100413 | 205369 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57853 | 205369 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44300798 | 205734 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58499 | 205734 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9845644 | 213212 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87964 | 213212 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 9985329 | 28908 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 562 | 9 | 2 | 6 | 6.8 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL132226 | 28908 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 562 | 9 | 2 | 6 | 6.8 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 15287894 | 61721 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16148 | 61721 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10324361 | 23698 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 519 | 12 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125273 | 23698 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 519 | 12 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 53309130 | 70546 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.6 | Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801734 | 70546 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.6 | Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 70690542 | 82996 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058375 | 82996 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 53309128 | 70556 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.4 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801744 | 70556 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.4 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 | 10.1021/jm200409s | |||
| 44277549 | 105904 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280988 | 105904 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 76315368 | 91730 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 510 | 10 | 2 | 8 | 5.3 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237587 | 91730 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 510 | 10 | 2 | 8 | 5.3 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956760 | 172279 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL424053 | 172279 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44348352 | 23300 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL123713 | 23300 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/S0960-894X(01)80914-8 | |||
| 44285157 | 161484 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 5.2 | CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39978 | 161484 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 5.2 | CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10412300 | 54922 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 467 | 9 | 1 | 7 | 5.7 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155154 | 54922 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 467 | 9 | 1 | 7 | 5.7 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44311472 | 110569 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308943 | 110569 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 10500716 | 17000 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 392 | 8 | 2 | 4 | 4.5 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL116054 | 17000 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 392 | 8 | 2 | 4 | 4.5 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 9867446 | 176096 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.1 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL441649 | 176096 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.1 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44305424 | 109270 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304032 | 109270 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10434949 | 126420 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL346745 | 126420 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10456123 | 172096 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL423418 | 172096 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76310609 | 112025 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115244 | 112025 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44298831 | 201762 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 496 | 8 | 2 | 8 | 4.2 | CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL54699 | 201762 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 496 | 8 | 2 | 8 | 4.2 | CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10434949 | 126420 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346745 | 126420 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10456123 | 172096 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL423418 | 172096 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15654731 | 108970 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 9 | 1 | 8 | 4.9 | CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302815 | 108970 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 9 | 1 | 8 | 4.9 | CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44305441 | 107722 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 7 | 2.0 | CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294075 | 107722 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 7 | 2.0 | CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44341795 | 16716 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 516 | 6 | 1 | 3 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114625 | 16716 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 516 | 6 | 1 | 3 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1021/jm00074a018 | |||
| 15144937 | 25604 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 500 | 11 | 1 | 4 | 7.4 | CCCCc1ncc(/C=C(\Cc2cccc(Oc3ccccc3)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL128032 | 25604 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 500 | 11 | 1 | 4 | 7.4 | CCCCc1ncc(/C=C(\Cc2cccc(Oc3ccccc3)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 44303886 | 107657 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293660 | 107657 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44303852 | 109126 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL303755 | 109126 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 73346387 | 99405 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 5.2 | CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435832 | 99405 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 5.2 | CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9866104 | 210674 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 407 | 10 | 1 | 5 | 4.6 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68919 | 210674 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 407 | 10 | 1 | 5 | 4.6 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| 9850385 | 108469 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 8 | 1 | 8 | 5.2 | CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL299391 | 108469 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 8 | 1 | 8 | 5.2 | CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 11757908 | 124112 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 12 | 0 | 6 | 6.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339709 | 124112 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 12 | 0 | 6 | 6.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127034874 | 143183 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735333 | 143183 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44212049 | 108241 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 560 | 8 | 1 | 7 | 6.7 | CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL297714 | 108241 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 560 | 8 | 1 | 7 | 6.7 | CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44297113 | 108352 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 637 | 9 | 1 | 9 | 6.8 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298560 | 108352 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 637 | 9 | 1 | 9 | 6.8 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 11388072 | 212611 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 634 | 9 | 1 | 9 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL83414 | 212611 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 634 | 9 | 1 | 9 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 57380648 | 77149 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945148 | 77149 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127034876 | 143204 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735487 | 143204 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10453551 | 25870 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cccc(N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL128913 | 25870 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cccc(N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 24827768 | 165873 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 411 | 6 | 1 | 7 | 3.5 | CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL409744 | 165873 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 411 | 6 | 1 | 7 | 3.5 | CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 15356438 | 193639 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 425 | 9 | 2 | 5 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48955 | 193639 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 425 | 9 | 2 | 5 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| 10483230 | 53604 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154027 | 53604 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19939367 | 112727 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL312921 | 112727 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956792 | 113543 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314447 | 113543 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956754 | 164164 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL407827 | 164164 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277440 | 105738 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL279756 | 105738 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44307171 | 107699 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 481 | 5 | 2 | 5 | 4.7 | CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL293926 | 107699 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 481 | 5 | 2 | 5 | 4.7 | CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 11374350 | 213183 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 6.0 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL87779 | 213183 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 6.0 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 44373246 | 175046 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL433895 | 175046 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | |||
| 9824568 | 211192 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL72053 | 211192 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 108185 | 8395 | 78 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00092a017 | |||
| 586 | 8395 | 78 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00092a017 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00092a017 | |||
| 10052777 | 55292 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 5.5 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155638 | 55292 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 5.5 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73355474 | 99392 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435819 | 99392 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 70696781 | 82997 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058376 | 82997 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 15236329 | 176113 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 598 | 6 | 1 | 7 | 6.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL441837 | 176113 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 598 | 6 | 1 | 7 | 6.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10501285 | 170214 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 3.7 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL419762 | 170214 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 3.7 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44320817 | 113769 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 5.3 | CCCCc1nc(Cl)c2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL315219 | 113769 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 5.3 | CCCCc1nc(Cl)c2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 44384871 | 136098 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367095 | 136098 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 11754522 | 28973 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 7 | 1 | 6 | 5.9 | CCCc1nc2ccc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL132282 | 28973 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 7 | 1 | 6 | 5.9 | CCCc1nc2ccc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10095637 | 56741 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15689 | 56741 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 19385665 | 57835 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15788 | 57835 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| 10053367 | 124024 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 553 | 12 | 0 | 7 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339480 | 124024 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 553 | 12 | 0 | 7 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10029695 | 165303 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 521 | 10 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL409136 | 165303 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 521 | 10 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9983135 | 175384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 492 | 11 | 0 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL435994 | 175384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 492 | 11 | 0 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL5271484 | 200465 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 44309702 | 210519 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67805 | 210519 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9869504 | 214826 | 4 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 214826 | 4 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 76322689 | 91734 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237591 | 91734 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956796 | 212578 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83182 | 212578 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44342013 | 16327 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 6.0 | CCCCC1=NC2(CCN(Cc3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL112343 | 16327 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 6.0 | CCCCC1=NC2(CCN(Cc3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19976676 | 213229 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cccnc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL88067 | 213229 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cccnc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 2541 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 587 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 6907 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL1016 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| DB00796 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| DB13919 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 2541 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 587 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 6907 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL1016 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| DB00796 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| DB13919 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 10006742 | 54696 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154949 | 54696 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9847539 | 188818 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47810 | 188818 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44297172 | 168997 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 2.9 | CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL416296 | 168997 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 2.9 | CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 10671263 | 16748 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 10 | 3 | 5 | 5.0 | CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL114788 | 16748 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 10 | 3 | 5 | 5.0 | CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10571686 | 16853 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 4.3 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL115392 | 16853 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 4.3 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 19939495 | 214604 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 214604 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 2541 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 587 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 6907 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| CHEMBL1016 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| DB00796 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| DB13919 | 7573 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 4110026 | 211714 | 1 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7632 | 211714 | 1 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 9886554 | 103881 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(CO)c(Cl)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL267547 | 103881 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(CO)c(Cl)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| 15699062 | 11699 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL104684 | 11699 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 15699051 | 12545 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c(-c3nn[nH]n3)cccc12 | 10.1021/jm00114a021 | |||
| CHEMBL107862 | 12545 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c(-c3nn[nH]n3)cccc12 | 10.1021/jm00114a021 | |||
| 44293476 | 108738 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 500 | 12 | 3 | 6 | 4.7 | CCCCc1ncc(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL301328 | 108738 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 500 | 12 | 3 | 6 | 4.7 | CCCCc1ncc(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44307088 | 108980 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 465 | 4 | 1 | 6 | 3.8 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL302869 | 108980 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 465 | 4 | 1 | 6 | 3.8 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44295557 | 108553 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299980 | 108553 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792135 | 196282 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51399 | 196282 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15355267 | 199983 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52343 | 199983 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 4110026 | 211714 | 1 | None | - | 1 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7632 | 211714 | 1 | None | - | 1 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 53837978 | 177228 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL4448705 | 177228 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | |||
| 44306628 | 210257 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 3 | 0 | 3 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL66056 | 210257 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 3 | 0 | 3 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44295557 | 108553 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299980 | 108553 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792135 | 196282 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51399 | 196282 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15355267 | 199983 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52343 | 199983 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034905 | 143137 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734859 | 143137 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44293652 | 108205 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 7 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](c2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297465 | 108205 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 7 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](c2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 24828714 | 102938 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.0 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O | 10.1021/jm7011563 | |||
| CHEMBL260578 | 102938 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.0 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O | 10.1021/jm7011563 | |||
| 14956759 | 212881 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85704 | 212881 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 73350990 | 99393 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 11 | 2 | 4 | 7.1 | CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435820 | 99393 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 11 | 2 | 4 | 7.1 | CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 19889359 | 166966 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL410939 | 166966 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 19889359 | 166966 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL410939 | 166966 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10257293 | 23691 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125233 | 23691 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70690743 | 83410 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063981 | 83410 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 70690743 | 83410 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063981 | 83410 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 14950487 | 101381 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 401 | 6 | 2 | 6 | 3.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL25220 | 101381 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 401 | 6 | 2 | 6 | 3.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 | 10.1021/jm00061a016 | |||
| 70688502 | 83103 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058857 | 83103 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 44459867 | 100660 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24802 | 100660 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44274710 | 106712 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL286260 | 106712 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 14956793 | 213087 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87129 | 213087 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956798 | 213188 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87798 | 213188 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 11397357 | 113791 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL315387 | 113791 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9954408 | 214746 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9714 | 214746 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 70684240 | 82998 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058377 | 82998 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44274710 | 106712 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL286260 | 106712 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19422649 | 108073 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 446 | 8 | 1 | 3 | 6.3 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL296492 | 108073 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 446 | 8 | 1 | 3 | 6.3 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44379347 | 127265 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354338 | 127265 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379291 | 127294 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354535 | 127294 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 3081289 | 16796 | 11 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115021 | 16796 | 11 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44377075 | 126755 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349869 | 126755 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44315180 | 109673 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 109673 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 15292112 | 109725 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 109725 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 14951068 | 108882 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 475 | 12 | 2 | 8 | 3.5 | CCCCc1nn(CCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL302261 | 108882 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 475 | 12 | 2 | 8 | 3.5 | CCCCc1nn(CCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14951083 | 109383 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 509 | 11 | 1 | 8 | 4.7 | CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL304134 | 109383 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 509 | 11 | 1 | 8 | 4.7 | CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44270330 | 58520 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15847 | 58520 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 44270278 | 105640 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278983 | 105640 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL5272962 | 200520 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 10324657 | 120494 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 12 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332323 | 120494 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 12 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 46184983 | 93595 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.2 | CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322437 | 93595 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.2 | CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44295057 | 108111 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL296731 | 108111 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44295068 | 195799 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL50906 | 195799 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44274691 | 102342 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 583 | 9 | 2 | 8 | 4.9 | CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25767 | 102342 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 583 | 9 | 2 | 8 | 4.9 | CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19010044 | 91740 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237597 | 91740 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956742 | 213107 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87275 | 213107 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9984755 | 54726 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154975 | 54726 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10074143 | 55771 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.5 | CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156070 | 55771 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.5 | CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 44358304 | 123569 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 5 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL337787 | 123569 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 5 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 11754802 | 123297 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL336167 | 123297 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 | 10.1021/jm00100a007 | |||
| 15231808 | 112778 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 5.1 | CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC=C2 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL313239 | 112778 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 5.1 | CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC=C2 | 10.1016/S0960-894X(01)80290-0 | |||
| 14950499 | 106294 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 6 | 2 | 6 | 3.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL283372 | 106294 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 6 | 2 | 6 | 3.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 | 10.1021/jm00061a016 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 15654764 | 109482 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 5.1 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL304772 | 109482 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 5.1 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10181864 | 211077 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.4 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71384 | 211077 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.4 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19385644 | 105527 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278061 | 105527 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10481742 | 126854 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL350697 | 126854 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44352156 | 175410 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 5.4 | CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL436192 | 175410 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 5.4 | CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 15780090 | 107231 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290669 | 107231 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10481742 | 126854 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350697 | 126854 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792113 | 194999 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49930 | 194999 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| 10322185 | 26708 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL130275 | 26708 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 | 10.1021/jm00100a007 | |||
| 10000936 | 27022 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2c(C)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130539 | 27022 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2c(C)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10250277 | 28365 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cc(C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131722 | 28365 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cc(C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15696755 | 154802 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL39345 | 154802 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 24827771 | 103158 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.1 | CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL261765 | 103158 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.1 | CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 24828035 | 103696 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 3.9 | CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265958 | 103696 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 3.9 | CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 689043 | 43570 | 115 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL145 | 43570 | 115 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| 18655106 | 207248 | 0 | None | - | 0 | Rabbit | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL59854 | 207248 | 0 | None | - | 0 | Rabbit | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| 76310606 | 112021 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115236 | 112021 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 127036106 | 143146 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734949 | 143146 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44294022 | 193404 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 543 | 12 | 2 | 6 | 5.7 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C#N)c2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48798 | 193404 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 543 | 12 | 2 | 6 | 5.7 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C#N)c2)cc1 | 10.1021/jm00064a007 | |||
| 44275144 | 100437 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24688 | 100437 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44275144 | 100437 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24688 | 100437 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11340575 | 113760 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 5.9 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL315165 | 113760 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 5.9 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 11476484 | 212841 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL85405 | 212841 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 11351776 | 212989 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(NC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86562 | 212989 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(NC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9896251 | 105549 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | |||
| CHEMBL278176 | 105549 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | |||
| 127034758 | 143148 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 12 | 1 | 8 | 7.7 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1039/C4MD00499J | |||
| CHEMBL3734968 | 143148 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 12 | 1 | 8 | 7.7 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1039/C4MD00499J | |||
| 9913391 | 57936 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157980 | 57936 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73357017 | 99404 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435831 | 99404 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10027148 | 123431 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337017 | 123431 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 | 10.1021/jm00100a007 | |||
| 44377262 | 63923 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 8 | 0 | 8 | 4.4 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164617 | 63923 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 8 | 0 | 8 | 4.4 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10437270 | 114190 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 9 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318042 | 114190 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 9 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00043a020 | |||
| 10416422 | 214778 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97295 | 214778 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10437261 | 123800 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 7 | 1 | 7 | 6.7 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL338954 | 123800 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 7 | 1 | 7 | 6.7 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 44404967 | 142196 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| CHEMBL372814 | 142196 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| 53309129 | 70545 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801714 | 70545 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 71521416 | 93603 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 6 | 1 | 8 | 5.1 | CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322445 | 93603 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 6 | 1 | 8 | 5.1 | CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76322690 | 91737 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237594 | 91737 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10055421 | 58182 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158188 | 58182 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 15698058 | 193902 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL49170 | 193902 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 14950501 | 91784 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22387 | 91784 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 | 10.1021/jm00061a016 | |||
| 15698058 | 193902 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL49170 | 193902 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15355266 | 201365 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL53074 | 201365 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44358503 | 34316 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL136911 | 34316 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 44288370 | 107897 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NC(=O)C2(CCCC2)CN1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL295181 | 107897 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NC(=O)C2(CCCC2)CN1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10455118 | 123215 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 4 | 5.6 | Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL336056 | 123215 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 4 | 5.6 | Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 11757357 | 214771 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97273 | 214771 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 19792113 | 194999 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49930 | 194999 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| 15355266 | 201365 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL53074 | 201365 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792097 | 108406 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298950 | 108406 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15654717 | 109421 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL304360 | 109421 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19792097 | 108406 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298950 | 108406 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 9894381 | 108817 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 574 | 8 | 1 | 7 | 7.0 | CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301827 | 108817 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 574 | 8 | 1 | 7 | 7.0 | CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 164625885 | 193045 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873899 | 193045 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 73352461 | 99403 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 5.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435830 | 99403 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 5.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 127035247 | 143297 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736338 | 143297 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 19792093 | 108709 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL301072 | 108709 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10030665 | 55649 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155948 | 55649 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10369225 | 55784 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156084 | 55784 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956766 | 113756 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315128 | 113756 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 10030665 | 55649 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155948 | 55649 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10369225 | 55784 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156084 | 55784 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10259265 | 116820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 116820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 15171393 | 92718 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL23006 | 92718 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 14950512 | 106603 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 7 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 | 10.1021/jm00061a016 | |||
| CHEMBL285560 | 106603 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 7 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 | 10.1021/jm00061a016 | |||
| 44305409 | 209589 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.8 | CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62314 | 209589 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.8 | CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385623 | 57209 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15730 | 57209 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10371118 | 22288 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 586 | 13 | 0 | 8 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121733 | 22288 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 586 | 13 | 0 | 8 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10415119 | 124862 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL340605 | 124862 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10030426 | 23393 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124144 | 23393 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 44315304 | 211789 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 211789 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 76319035 | 91754 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 541 | 11 | 3 | 8 | 5.4 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237611 | 91754 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 541 | 11 | 3 | 8 | 5.4 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11511750 | 103330 | 1 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL262958 | 103330 | 1 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44294051 | 181738 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 604 | 14 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL45659 | 181738 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 604 | 14 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| 44294031 | 190743 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 532 | 12 | 2 | 5 | 6.1 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48168 | 190743 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 532 | 12 | 2 | 5 | 6.1 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C)cc1 | 10.1021/jm00064a007 | |||
| 44341713 | 16503 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.9 | CCCCC1=NC2(CCN(C(=O)C(F)(F)F)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113330 | 16503 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.9 | CCCCC1=NC2(CCN(C(=O)C(F)(F)F)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 15171409 | 213070 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL87034 | 213070 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44348042 | 23547 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL124449 | 23547 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 127028595 | 144145 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753047 | 144145 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 9986861 | 126461 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 10 | 2 | 7 | 5.8 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347236 | 126461 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 10 | 2 | 7 | 5.8 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44438868 | 98779 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241684 | 98779 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10412769 | 27023 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL130540 | 27023 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 | 10.1021/jm00100a007 | |||
| 10049787 | 29238 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132509 | 29238 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 | 10.1021/jm00100a007 | |||
| 168288304 | 198150 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| CHEMBL5192190 | 198150 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| 168293707 | 198944 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| CHEMBL5203983 | 198944 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| 19385652 | 54292 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15458 | 54292 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10456700 | 126446 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347050 | 126446 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44459583 | 100049 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24499 | 100049 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 15699069 | 11862 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| CHEMBL105525 | 11862 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| 44285212 | 157240 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 546 | 7 | 1 | 5 | 6.3 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39542 | 157240 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 546 | 7 | 1 | 5 | 6.3 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10456700 | 126446 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347050 | 126446 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44563174 | 181199 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 8.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL455286 | 181199 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 8.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 19792093 | 108709 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL301072 | 108709 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44303888 | 210058 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64674 | 210058 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44298775 | 204427 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.1 | COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL57090 | 204427 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.1 | COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10620305 | 16880 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115560 | 16880 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 73349423 | 99395 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 5.7 | CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435822 | 99395 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 5.7 | CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 24828294 | 102602 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 4.3 | CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| CHEMBL258891 | 102602 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 4.3 | CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| 44294052 | 108178 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 618 | 14 | 1 | 8 | 6.4 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297265 | 108178 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 618 | 14 | 1 | 8 | 6.4 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| 10347373 | 55310 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155661 | 55310 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11755714 | 127018 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL352235 | 127018 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956744 | 212942 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86255 | 212942 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44459896 | 103052 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26113 | 103052 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 10347373 | 55310 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155661 | 55310 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 11755714 | 127018 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL352235 | 127018 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44377263 | 171677 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.7 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL422200 | 171677 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.7 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10417195 | 115856 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 115856 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44315058 | 77228 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 77228 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44372814 | 126568 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| CHEMBL348157 | 126568 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| 44320519 | 113950 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 7 | 1 | 7 | 4.6 | CCCCc1ncc2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL316392 | 113950 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 7 | 1 | 7 | 4.6 | CCCCc1ncc2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 44309299 | 109115 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 12 | 0 | 9 | 5.1 | CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL303683 | 109115 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 12 | 0 | 9 | 5.1 | CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00067a015 | |||
| 10223724 | 212536 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL82797 | 212536 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14951062 | 213170 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87669 | 213170 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10411441 | 58564 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15850 | 58564 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44381431 | 65275 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168346 | 65275 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 53309273 | 70549 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.6 | CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C | 10.1021/jm200409s | |||
| CHEMBL1801737 | 70549 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.6 | CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C | 10.1021/jm200409s | |||
| 10324179 | 121153 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333126 | 121153 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44342089 | 16817 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115193 | 16817 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1021/jm00074a018 | |||
| 44341702 | 16870 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 434 | 11 | 1 | 3 | 6.3 | CCCCC1=NC(CCC)(CCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115492 | 16870 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 434 | 11 | 1 | 3 | 6.3 | CCCCC1=NC(CCC)(CCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19976810 | 213133 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cnccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL87411 | 213133 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cnccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 19422654 | 108175 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(C)(CC2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL297250 | 108175 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(C)(CC2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44297010 | 108404 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298943 | 108404 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 19102815 | 214657 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 214657 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44296547 | 195118 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 3 | 5 | 3.1 | CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL50092 | 195118 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 3 | 5 | 3.1 | CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 15654750 | 110373 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.5 | CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308651 | 110373 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.5 | CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44563176 | 178223 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL446314 | 178223 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 19792183 | 108556 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299994 | 108556 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44210317 | 109988 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL308424 | 109988 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 14951055 | 211111 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 351 | 7 | 2 | 5 | 3.7 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL71518 | 211111 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 351 | 7 | 2 | 5 | 3.7 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| 19792183 | 108556 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299994 | 108556 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034757 | 143173 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735265 | 143173 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 127036104 | 143248 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735910 | 143248 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127036294 | 143129 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734815 | 143129 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24828567 | 103077 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 1 | 5 | 4.4 | CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL261248 | 103077 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 1 | 5 | 4.4 | CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44296953 | 201542 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53803 | 201542 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127035514 | 143201 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735446 | 143201 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10094859 | 26762 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 1 | 4 | 5.8 | CCCc1nc2c(C)cc(CN(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130322 | 26762 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 1 | 4 | 5.8 | CCCc1nc2c(C)cc(CN(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10371295 | 120302 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 596 | 12 | 0 | 6 | 6.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332152 | 120302 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 596 | 12 | 0 | 6 | 6.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956745 | 213048 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86906 | 213048 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44307122 | 209775 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 349 | 3 | 1 | 4 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63144 | 209775 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 349 | 3 | 1 | 4 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9823146 | 26133 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL12909 | 26133 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | |||
| 127035410 | 143163 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL3735155 | 143163 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 70692693 | 82990 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058369 | 82990 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44438880 | 98761 | 0 | None | - | 1 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241523 | 98761 | 0 | None | - | 1 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44297143 | 108028 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 547 | 8 | 1 | 8 | 5.3 | CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL296173 | 108028 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 547 | 8 | 1 | 8 | 5.3 | CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 9886863 | 40693 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL142380 | 40693 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 10078800 | 115968 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 115968 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9886863 | 40693 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| CHEMBL142380 | 40693 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| 14951066 | 109836 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 9 | 1 | 9 | 3.6 | CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL307310 | 109836 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 9 | 1 | 9 | 3.6 | CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10183373 | 171789 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL422593 | 171789 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 19811543 | 210150 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 9 | 1 | 7 | 3.7 | CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65224 | 210150 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 9 | 1 | 7 | 3.7 | CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 19385586 | 56500 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15669 | 56500 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10049400 | 162219 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40381 | 162219 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44381603 | 65890 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169798 | 65890 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 10323969 | 23180 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 9 | 0 | 8 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123091 | 23180 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 9 | 0 | 8 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70682146 | 83106 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2058860 | 83106 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10325767 | 119851 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 13 | 0 | 8 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331219 | 119851 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 13 | 0 | 8 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 53309275 | 70551 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.8 | CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801739 | 70551 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.8 | CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 44306647 | 107681 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL293846 | 107681 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 127034756 | 143131 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734829 | 143131 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 15780064 | 106399 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL284123 | 106399 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 44438901 | 98762 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241529 | 98762 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10390316 | 28788 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132115 | 28788 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 | 10.1021/jm00100a007 | |||
| 9984310 | 27852 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cccc(NC(=O)NC3CCCCC3)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131209 | 27852 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cccc(NC(=O)NC3CCCCC3)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10367325 | 175189 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 6.8 | CCCCc1nc2ccc(N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL434815 | 175189 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 6.8 | CCCCc1nc2ccc(N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 10096347 | 56189 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156449 | 56189 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44298758 | 200933 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL52824 | 200933 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44321129 | 118244 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL327614 | 118244 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| 10096347 | 56189 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156449 | 56189 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 54768660 | 71891 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824000 | 71891 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44309040 | 109764 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 7 | 1 | 7 | 3.9 | CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL306670 | 109764 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 7 | 1 | 7 | 3.9 | CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44459707 | 100132 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL24550 | 100132 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 127028618 | 144055 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 4.9 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752198 | 144055 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 4.9 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127034903 | 143216 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735641 | 143216 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24827902 | 164512 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL408227 | 164512 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 76325126 | 112022 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.1 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115241 | 112022 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.1 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 71653152 | 95927 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337682 | 95927 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365924 | 95927 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 76311800 | 91733 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 538 | 11 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237590 | 91733 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 538 | 11 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956784 | 113334 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314179 | 113334 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956764 | 212856 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85541 | 212856 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 11316515 | 212971 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 5 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86437 | 212971 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 5 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9889557 | 103828 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 3 | 7 | 2.7 | CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL267056 | 103828 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 3 | 7 | 2.7 | CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10028751 | 171695 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 6.1 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL422333 | 171695 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 6.1 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10010164 | 124175 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 124175 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 14951070 | 210648 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 13 | 2 | 8 | 3.9 | CCCCc1nn(CCCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68731 | 210648 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 13 | 2 | 8 | 3.9 | CCCCc1nn(CCCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 9930953 | 109579 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305350 | 109579 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10393086 | 23289 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123670 | 23289 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 11758470 | 119788 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331121 | 119788 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15780091 | 127774 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35638 | 127774 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9982960 | 126625 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348616 | 126625 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10475047 | 124223 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL339846 | 124223 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 10141058 | 210572 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 14 | 1 | 7 | 5.6 | CCCCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| CHEMBL68275 | 210572 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 14 | 1 | 7 | 5.6 | CCCCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| 10161446 | 109550 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.7 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL305190 | 109550 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.7 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654758 | 210626 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 3 | 7 | 3.7 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68597 | 210626 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 3 | 7 | 3.7 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654742 | 210848 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 4.6 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70074 | 210848 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 4.6 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19385675 | 58148 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15816 | 58148 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10004159 | 126328 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345894 | 126328 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44291830 | 185450 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL46782 | 185450 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10004159 | 126328 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345894 | 126328 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44291830 | 185450 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL46782 | 185450 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 11741660 | 123923 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2c(N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL339360 | 123923 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2c(N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 4823 | 100337 | 91 | None | - | 0 | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL24646 | 100337 | 91 | None | - | 0 | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 164620345 | 192992 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873167 | 192992 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 44296955 | 201454 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53226 | 201454 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14956741 | 113831 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315615 | 113831 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44341731 | 16970 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 4.4 | CCCCC1=NC2(CCN(C(C)=O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115984 | 16970 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 4.4 | CCCCC1=NC2(CCN(C(C)=O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19889373 | 212956 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL86346 | 212956 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 1610 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 3941 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 3961 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 590 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| DB00678 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL5271135 | 200450 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 24827770 | 102655 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259114 | 102655 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19422638 | 180995 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 5.2 | CCCCC1=NC(C)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL45485 | 180995 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 5.2 | CCCCC1=NC(C)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 1610 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 3941 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 3961 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 590 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 10099830 | 115268 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319955 | 115268 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 44315349 | 67164 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 67164 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 1610 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 3941 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 3961 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 590 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 10140958 | 109786 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL306882 | 109786 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14956804 | 112776 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL313222 | 112776 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 15287891 | 130469 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL36218 | 130469 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 10007528 | 23065 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122490 | 23065 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277595 | 13096 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 621 | 9 | 0 | 10 | 5.4 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL108190 | 13096 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 621 | 9 | 0 | 10 | 5.4 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44294996 | 196572 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51622 | 196572 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44293657 | 182436 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 534 | 12 | 3 | 6 | 5.3 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL45814 | 182436 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 534 | 12 | 3 | 6 | 5.3 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44293954 | 194478 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 12 | 3 | 7 | 5.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49526 | 194478 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 12 | 3 | 7 | 5.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44296985 | 201182 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 1 | 8 | 6.9 | CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52880 | 201182 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 1 | 8 | 6.9 | CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 10453972 | 28959 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.5 | Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132269 | 28959 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.5 | Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 14951081 | 210471 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 581 | 14 | 1 | 10 | 4.6 | CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL67515 | 210471 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 581 | 14 | 1 | 10 | 4.6 | CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10366029 | 121989 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL334515 | 121989 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44381714 | 65895 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169827 | 65895 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44341801 | 16574 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113701 | 16574 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44341772 | 117369 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 418 | 7 | 0 | 4 | 5.4 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325502 | 117369 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 418 | 7 | 0 | 4 | 5.4 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1021/jm00074a018 | |||
| 44321129 | 118244 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL327614 | 118244 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| 10026315 | 122882 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cccc(NC(C)=O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL335734 | 122882 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cccc(NC(C)=O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 24827899 | 103664 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 411 | 5 | 1 | 7 | 3.4 | CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265697 | 103664 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 411 | 5 | 1 | 7 | 3.4 | CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 44348302 | 23263 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL123562 | 23263 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| 44438870 | 98780 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241685 | 98780 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44291438 | 190610 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL48062 | 190610 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44348302 | 23263 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| CHEMBL123562 | 23263 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 71521299 | 93599 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 6 | 1 | 7 | 4.8 | CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322441 | 93599 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 6 | 1 | 7 | 4.8 | CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 127036102 | 143292 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736295 | 143292 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL5075338 | 221147 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||||
| 70686409 | 83101 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058855 | 83101 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71521196 | 93597 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 8 | 1 | 9 | 4.9 | CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322439 | 93597 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 8 | 1 | 9 | 4.9 | CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 10098452 | 58214 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158209 | 58214 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341651 | 117260 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL324785 | 117260 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10098452 | 58214 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158209 | 58214 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15231798 | 213221 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 452 | 9 | 1 | 5 | 6.4 | CCCCc1nc(CCCC)n2c1C=CCC2c1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL88014 | 213221 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 452 | 9 | 1 | 5 | 6.4 | CCCCc1nc(CCCC)n2c1C=CCC2c1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| 14950502 | 92410 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 6 | 3.9 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22837 | 92410 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 6 | 3.9 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 | 10.1021/jm00061a016 | |||
| 15654756 | 109176 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.4 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303955 | 109176 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.4 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654741 | 210763 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 5 | 2 | 6 | 3.9 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69522 | 210763 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 5 | 2 | 6 | 3.9 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 22596780 | 211179 | 1 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 4.5 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71954 | 211179 | 1 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 4.5 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a016 | |||
| 10321914 | 126826 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL350446 | 126826 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10321914 | 126826 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350446 | 126826 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 54768661 | 71892 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 8 | 1 | 8 | 5.3 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824001 | 71892 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 8 | 1 | 8 | 5.3 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44293991 | 108457 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 532 | 12 | 1 | 6 | 5.9 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299324 | 108457 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 532 | 12 | 1 | 6 | 5.9 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| 11757216 | 23392 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 12 | 0 | 8 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124141 | 23392 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 12 | 0 | 8 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 57380649 | 77150 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945149 | 77150 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 2121583 | 30148 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1332729 | 30148 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 2121583 | 30148 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1332729 | 30148 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 44274672 | 98329 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 8 | 2 | 7 | 4.7 | CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24053 | 98329 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 8 | 2 | 7 | 4.7 | CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274824 | 106039 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL281846 | 106039 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956756 | 213150 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87513 | 213150 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 136401481 | 167617 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 11 | 5.7 | CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL4114737 | 167617 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 11 | 5.7 | CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44274824 | 106039 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL281846 | 106039 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311583 | 210899 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70353 | 210899 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10209324 | 21262 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL12013 | 21262 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 9871837 | 21975 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 10 | 2 | 7 | 4.9 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1039/C4MD00499J | |||
| CHEMBL12106 | 21975 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 10 | 2 | 7 | 4.9 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1039/C4MD00499J | |||
| 15222070 | 109074 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL303426 | 109074 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311662 | 109458 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304620 | 109458 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| 15222094 | 109751 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306489 | 109751 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311681 | 109800 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306961 | 109800 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222092 | 110601 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309165 | 110601 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311451 | 110879 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309367 | 110879 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311497 | 174636 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL430997 | 174636 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311663 | 210968 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70796 | 210968 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311499 | 211178 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71953 | 211178 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311648 | 211306 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72721 | 211306 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311758 | 211450 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL73780 | 211450 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 19742811 | 64195 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165354 | 64195 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10077555 | 214189 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93956 | 214189 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| 10440144 | 123672 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 123672 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315349 | 67164 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 67164 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 108185 | 8395 | 78 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 586 | 8395 | 78 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 44285372 | 107067 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL289105 | 107067 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44338666 | 117735 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL326217 | 117735 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 9850834 | 161441 | 17 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL39959 | 161441 | 17 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 14956779 | 75438 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL19202 | 75438 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10031067 | 107128 | 4 | None | - | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL289614 | 107128 | 4 | None | - | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 127030943 | 145973 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787243 | 145973 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787375 | 145973 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 145973 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 44277462 | 21544 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL1206522 | 21544 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281890 | 21544 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277548 | 106186 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 0 | 10 | 4.6 | COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282777 | 106186 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 0 | 10 | 4.6 | COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10479475 | 122004 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL334670 | 122004 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00050a002 | |||
| 44288322 | 161980 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 470 | 7 | 1 | 5 | 5.8 | CCCCC1=NC2(CCCC2)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL40251 | 161980 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 470 | 7 | 1 | 5 | 5.8 | CCCCC1=NC2(CCCC2)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10393837 | 174723 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL431619 | 174723 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| 10462573 | 123787 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 123787 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372550 | 171295 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 171295 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315344 | 111858 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 111858 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 18950607 | 57192 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15729 | 57192 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10004646 | 24725 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126037 | 24725 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052253 | 131302 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 624 | 10 | 1 | 11 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 | nan | |||
| CHEMBL3640160 | 131302 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 624 | 10 | 1 | 11 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 | nan | |||
| 44278118 | 103761 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 587 | 9 | 0 | 8 | 5.9 | CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL266480 | 103761 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 587 | 9 | 0 | 8 | 5.9 | CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277737 | 107398 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29192 | 107398 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44315180 | 109673 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 109673 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315059 | 211491 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 211491 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315057 | 211608 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 211608 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19802473 | 205484 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58156 | 205484 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44305267 | 210180 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65503 | 210180 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10101582 | 126154 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344466 | 126154 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1007/s00044-013-0831-x | |||
| 9979771 | 24218 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125766 | 24218 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9935106 | 72056 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL18287 | 72056 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44338708 | 117221 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL324629 | 117221 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277443 | 107074 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28918 | 107074 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL938 | 222686 | 28 | None | - | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm00074a018 | |||||
| 9935106 | 72056 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL18287 | 72056 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 57380412 | 77303 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947129 | 77303 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44303230 | 207426 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL59957 | 207426 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349506 | 214838 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97615 | 214838 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| 44305681 | 109404 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304251 | 109404 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10101582 | 126154 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| CHEMBL344466 | 126154 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| 76333687 | 92034 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 506 | 11 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259779 | 92034 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 506 | 11 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15231091 | 100763 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24861 | 100763 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44338697 | 116436 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL322471 | 116436 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277738 | 106962 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 7 | 0 | 8 | 6.3 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28816 | 106962 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 7 | 0 | 8 | 6.3 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 76324571 | 110758 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 378 | 7 | 1 | 8 | 1.9 | CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2013.10.017 | |||
| CHEMBL3092993 | 110758 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 378 | 7 | 1 | 8 | 1.9 | CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2013.10.017 | |||
| 9939191 | 105722 | 1 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15231091 | 100763 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24861 | 100763 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10095986 | 23265 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123568 | 23265 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277901 | 108169 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 4.7 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29722 | 108169 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 4.7 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 11764669 | 73594 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL18606 | 73594 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 46910495 | 83107 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058861 | 83107 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 54578725 | 71901 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 8 | 3 | 7 | 4.0 | CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824184 | 71901 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 8 | 3 | 7 | 4.0 | CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44211506 | 64315 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166338 | 64315 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376780 | 63278 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163486 | 63278 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349845 | 18134 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179731 | 18134 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97271 | 18134 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 11764669 | 73594 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL18606 | 73594 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10054753 | 214925 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98140 | 214925 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 135723840 | 145920 | 0 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787059 | 145920 | 0 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 9984303 | 24369 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125818 | 24369 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035264 | 143284 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736244 | 143284 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 183134 | 211623 | 17 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm200409s | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm200409s | |||
| 2806 | 10741 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 3937 | 10741 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 593 | 10741 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 60846 | 10741 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| DB00177 | 10741 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 10342301 | 24710 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125937 | 24710 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277547 | 105979 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 10 | 0 | 9 | 6.2 | CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281453 | 105979 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 10 | 0 | 9 | 6.2 | CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277463 | 108083 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29654 | 108083 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44348408 | 120350 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL332239 | 120350 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| 44379086 | 63352 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164174 | 63352 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 108185 | 8395 | 78 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| 586 | 8395 | 78 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| 10372723 | 114095 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317368 | 114095 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10349029 | 214875 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97812 | 214875 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| 145946921 | 174379 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337687 | 174379 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337688 | 174379 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL4300967 | 174379 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 10298977 | 213102 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87239 | 213102 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 131654 | 213182 | 12 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87778 | 213182 | 12 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10055096 | 105061 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL274712 | 105061 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 25147556 | 180642 | 0 | None | - | 0 | Bovine | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL453934 | 180642 | 0 | None | - | 0 | Bovine | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44377261 | 126696 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 1 | 7 | 3.6 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349389 | 126696 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 1 | 7 | 3.6 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10055096 | 105061 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274712 | 105061 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 44316916 | 212075 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL79242 | 212075 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44295009 | 193950 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49207 | 193950 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44275060 | 106491 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 7 | 2 | 7 | 6.3 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284764 | 106491 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 7 | 2 | 7 | 6.3 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10370172 | 57602 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157690 | 57602 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44277444 | 107714 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 11 | 0 | 8 | 6.5 | CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29402 | 107714 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 11 | 0 | 8 | 6.5 | CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 15356436 | 108791 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 514 | 12 | 3 | 6 | 4.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL301705 | 108791 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 514 | 12 | 3 | 6 | 4.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44311406 | 110584 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309081 | 110584 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44341670 | 16728 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 434 | 9 | 1 | 3 | 6.0 | CCCCC1=NC(C(C)C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114687 | 16728 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 434 | 9 | 1 | 3 | 6.0 | CCCCC1=NC(C(C)C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44322315 | 213037 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 7 | 1 | 7 | 4.7 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86858 | 213037 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 7 | 1 | 7 | 4.7 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44285177 | 145434 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 4.9 | CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL37768 | 145434 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 4.9 | CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10370172 | 57602 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157690 | 57602 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 73349424 | 99406 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435833 | 99406 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44311568 | 104960 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL273992 | 104960 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311636 | 210908 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70389 | 210908 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311569 | 211483 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL74113 | 211483 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44377086 | 126729 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349652 | 126729 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10202093 | 213214 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87985 | 213214 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44305267 | 210180 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65503 | 210180 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385603 | 105555 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278234 | 105555 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 44294976 | 168446 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL413098 | 168446 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 15699056 | 116457 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| CHEMBL322683 | 116457 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| 44459821 | 103159 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.2 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26179 | 103159 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.2 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11930 | 7806 | 0 | None | - | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 15780052 | 7806 | 0 | None | - | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL289472 | 7806 | 0 | None | - | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44438869 | 153113 | 0 | None | - | 1 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL392118 | 153113 | 0 | None | - | 1 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | |||
| 10600595 | 117925 | 23 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 9 | 2 | 8 | 4.1 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL326400 | 117925 | 23 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 9 | 2 | 8 | 4.1 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44342142 | 16719 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL114653 | 16719 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 10363869 | 27238 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3ccc(-c4nn[nH]n4)c3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL13071 | 27238 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3ccc(-c4nn[nH]n4)c3)cc2)n1 | 10.1021/jm00053a013 | |||
| 54768659 | 71890 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 507 | 8 | 1 | 8 | 4.6 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1823999 | 71890 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 507 | 8 | 1 | 8 | 4.6 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 10096495 | 26149 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL129194 | 26149 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 | 10.1021/jm00100a007 | |||
| 15699055 | 11903 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2ccc(-c3nn[nH]n3)cc2c1 | 10.1021/jm00114a021 | |||
| CHEMBL105724 | 11903 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2ccc(-c3nn[nH]n3)cc2c1 | 10.1021/jm00114a021 | |||
| 10810628 | 201469 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL53322 | 201469 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 44309366 | 210879 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 4.4 | CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL70239 | 210879 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 4.4 | CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 10810628 | 201469 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL53322 | 201469 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 127035068 | 143151 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735036 | 143151 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 164611280 | 191778 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4854474 | 191778 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 53309272 | 70548 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.3 | CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801736 | 70548 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.3 | CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 1315061 | 35017 | 9 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1374011 | 35017 | 9 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 | 10.1016/j.bmc.2016.07.047 | |||
| 70682147 | 83112 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058866 | 83112 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10029950 | 57415 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157524 | 57415 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956750 | 212864 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85596 | 212864 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277653 | 108185 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 645 | 11 | 0 | 9 | 5.9 | CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29730 | 108185 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 645 | 11 | 0 | 9 | 5.9 | CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 18004820 | 23225 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 9 | 2 | 7 | 4.7 | CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL12333 | 23225 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 9 | 2 | 7 | 4.7 | CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10029950 | 57415 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157524 | 57415 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44377198 | 63295 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163628 | 63295 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10259334 | 214817 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97500 | 214817 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| 23590371 | 168184 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 553 | 12 | 1 | 10 | 4.2 | CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL412664 | 168184 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 553 | 12 | 1 | 10 | 4.2 | CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10076199 | 123433 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 548 | 9 | 3 | 6 | 6.7 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL337025 | 123433 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 548 | 9 | 3 | 6 | 6.7 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 9805344 | 105816 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280290 | 105816 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15287886 | 144388 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 6.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL37566 | 144388 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 6.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44286911 | 168568 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 5 | 1 | 2 | 6.2 | O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41416 | 168568 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 5 | 1 | 2 | 6.2 | O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44277462 | 21544 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL1206522 | 21544 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281890 | 21544 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10077513 | 24046 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125697 | 24046 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44294989 | 169985 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL418269 | 169985 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44293466 | 107917 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 14 | 1 | 8 | 6.0 | CCCCc1nc(Cl)c(CCC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL295311 | 107917 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 14 | 1 | 8 | 6.0 | CCCCc1nc(Cl)c(CCC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 44293962 | 108165 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 518 | 12 | 2 | 5 | 5.8 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297202 | 108165 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 518 | 12 | 2 | 5 | 5.8 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| 44293990 | 194106 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 12 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49306 | 194106 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 12 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 10073122 | 126566 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL348149 | 126566 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44291654 | 181046 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL45493 | 181046 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10073122 | 126566 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348149 | 126566 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44291654 | 181046 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL45493 | 181046 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44296533 | 201521 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 393 | 8 | 3 | 4 | 4.0 | CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL53631 | 201521 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 393 | 8 | 3 | 4 | 4.0 | CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44304147 | 107553 | 0 | None | - | 0 | Rabbit | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL292939 | 107553 | 0 | None | - | 0 | Rabbit | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 46910583 | 77127 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945008 | 77127 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127036297 | 143205 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735492 | 143205 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11190917 | 175586 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL437659 | 175586 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 127035219 | 143136 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734849 | 143136 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 4803452 | 46408 | 6 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 4 | 3.6 | Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1474431 | 46408 | 6 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 4 | 3.6 | Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 | 10.1016/j.bmc.2016.07.047 | |||
| 10275744 | 212897 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85876 | 212897 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15356432 | 193448 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 14 | 3 | 6 | 5.9 | CCCCc1nc(Cl)c(CCC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48824 | 193448 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 14 | 3 | 6 | 5.9 | CCCCc1nc(Cl)c(CCC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44307195 | 109035 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL303186 | 109035 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44264673 | 211471 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 4.3 | CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7396 | 211471 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 4.3 | CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44459662 | 102819 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL25989 | 102819 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 108185 | 8395 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| 586 | 8395 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| 10027836 | 25721 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128644 | 25721 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1021/jm00100a007 | |||
| 44309264 | 109454 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 12 | 2 | 10 | 4.0 | CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL304600 | 109454 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 12 | 2 | 10 | 4.0 | CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10222835 | 212924 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL86084 | 212924 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 108185 | 8395 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 586 | 8395 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL5271903 | 200481 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5273768 | 200555 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 46910494 | 83108 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058862 | 83108 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 44341489 | 16072 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 575 | 12 | 4 | 6 | 2.7 | CCCCC1=NC2(CCN(C(=O)C(N)CCCN=C(N)N)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL110974 | 16072 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 575 | 12 | 4 | 6 | 2.7 | CCCCC1=NC2(CCN(C(=O)C(N)CCCN=C(N)N)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10096463 | 55656 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155954 | 55656 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10435012 | 123788 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL338900 | 123788 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 | 10.1021/jm00100a007 | |||
| 44309242 | 210244 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 6 | 1 | 5 | 4.3 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL65955 | 210244 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 6 | 1 | 5 | 4.3 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44308785 | 210857 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 420 | 5 | 1 | 3 | 5.0 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL70134 | 210857 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 420 | 5 | 1 | 3 | 5.0 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 14956797 | 213198 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87885 | 213198 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 76321525 | 112024 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 552 | 9 | 1 | 7 | 7.2 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115243 | 112024 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 552 | 9 | 1 | 7 | 7.2 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44278151 | 105889 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 11 | 0 | 9 | 5.4 | CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280875 | 105889 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 11 | 0 | 9 | 5.4 | CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9824568 | 211192 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL72053 | 211192 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| 127035716 | 143212 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735588 | 143212 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44211673 | 66494 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL172376 | 66494 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 14950503 | 106328 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| CHEMBL283579 | 106328 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| 44305410 | 169138 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL416507 | 169138 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 73346386 | 99391 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2435818 | 99391 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10460186 | 123637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 548 | 12 | 0 | 7 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338123 | 123637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 548 | 12 | 0 | 7 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694919 | 83412 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063983 | 83412 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 130762 | 105023 | 9 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44291524 | 191055 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(C)(CC(C)CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL48392 | 191055 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(C)(CC(C)CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 24827769 | 102656 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.7 | CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259116 | 102656 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.7 | CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 54771778 | 71895 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 479 | 8 | 2 | 8 | 5.0 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824004 | 71895 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 479 | 8 | 2 | 8 | 5.0 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 15287889 | 107213 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 9 | 2 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL290465 | 107213 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 9 | 2 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 19008935 | 168636 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 463 | 6 | 1 | 6 | 5.8 | CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL414836 | 168636 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 463 | 6 | 1 | 6 | 5.8 | CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| 19010059 | 91741 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237598 | 91741 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 73349223 | 98965 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL2425138 | 98965 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 44293696 | 108428 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 13 | 3 | 7 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299130 | 108428 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 13 | 3 | 7 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341794 | 16656 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 8 | 1 | 3 | 5.7 | CCCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114267 | 16656 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 8 | 1 | 3 | 5.7 | CCCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 53320976 | 64383 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 4.8 | CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668124 | 64383 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 4.8 | CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10280531 | 169710 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 5.1 | CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL417429 | 169710 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 5.1 | CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 70694919 | 83412 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063983 | 83412 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10436877 | 54769 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155008 | 54769 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9914502 | 126483 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347392 | 126483 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10327728 | 104898 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 104898 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44300734 | 108583 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL300154 | 108583 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9982171 | 27277 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 8 | 2 | 4 | 5.9 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130741 | 27277 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 8 | 2 | 4 | 5.9 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 11765394 | 125555 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| CHEMBL341986 | 125555 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| 44341946 | 16365 | 13 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL112523 | 16365 | 13 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL5282200 | 200928 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 71521195 | 93596 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 8 | 3.2 | CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322438 | 93596 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 8 | 3.2 | CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44293939 | 107976 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 590 | 14 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL295737 | 107976 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 590 | 14 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2)cc1 | 10.1021/jm00064a007 | |||
| 10414026 | 164290 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 511 | 7 | 1 | 7 | 6.7 | CCCc1nc2ccc(-c3nc4ccccc4o3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL407978 | 164290 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 511 | 7 | 1 | 7 | 6.7 | CCCc1nc2ccc(-c3nc4ccccc4o3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 44298772 | 202353 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 452 | 8 | 1 | 7 | 4.3 | CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55507 | 202353 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 452 | 8 | 1 | 7 | 4.3 | CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44295568 | 108377 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298741 | 108377 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10255042 | 123595 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 490 | 10 | 1 | 4 | 7.3 | CCCCc1ncc(/C=C(/C(=O)O)C(c2ccccc2)c2cccs2)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL337928 | 123595 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 490 | 10 | 1 | 4 | 7.3 | CCCCc1ncc(/C=C(/C(=O)O)C(c2ccccc2)c2cccs2)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 44305823 | 169696 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 7 | 2.3 | Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL417410 | 169696 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 7 | 2.3 | Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 44295568 | 108377 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298741 | 108377 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10459724 | 24748 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126170 | 24748 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70688681 | 83414 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063985 | 83414 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 70688681 | 83414 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063985 | 83414 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44306706 | 209868 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 654 | 10 | 1 | 6 | 7.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63879 | 209868 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 654 | 10 | 1 | 6 | 7.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44379185 | 64328 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166428 | 64328 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 14950506 | 92569 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 6 | 1 | 6 | 5.2 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22945 | 92569 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 6 | 1 | 6 | 5.2 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171385 | 173728 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 | 10.1021/jm00061a016 | |||
| CHEMBL428711 | 173728 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 | 10.1021/jm00061a016 | |||
| 14951063 | 108916 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 551 | 10 | 1 | 8 | 5.1 | CCCCc1nn(CC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL302478 | 108916 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 551 | 10 | 1 | 8 | 5.1 | CCCCc1nn(CC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44305400 | 209725 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 3.9 | CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62936 | 209725 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 3.9 | CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 76315849 | 92186 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 13 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263542 | 92186 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 13 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL5277518 | 200715 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 9912059 | 192135 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL48602 | 192135 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44306709 | 109466 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 547 | 6 | 1 | 5 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL304655 | 109466 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 547 | 6 | 1 | 5 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44341585 | 16679 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 522 | 9 | 3 | 6 | 3.6 | CCCCC1=NC2(CCN(C(=O)C(N)CS)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114368 | 16679 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 522 | 9 | 3 | 6 | 3.6 | CCCCC1=NC2(CCN(C(=O)C(N)CS)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44298759 | 196651 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 3.9 | CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL51689 | 196651 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 3.9 | CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 19976317 | 213168 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccncc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL87655 | 213168 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccncc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 9912059 | 192135 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL48602 | 192135 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44348378 | 170992 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL421094 | 170992 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 71521507 | 93583 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322173 | 93583 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 19889599 | 108619 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300451 | 108619 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44438902 | 176175 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL442251 | 176175 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 15654748 | 210705 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.8 | COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69144 | 210705 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.8 | COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 9912059 | 192135 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL48602 | 192135 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 19889599 | 108619 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300451 | 108619 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44294181 | 194015 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 607 | 14 | 2 | 8 | 6.2 | CCCCc1nc(-n2cccc2)c(C(=O)OCC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49257 | 194015 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 607 | 14 | 2 | 8 | 6.2 | CCCCc1nc(-n2cccc2)c(C(=O)OCC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341785 | 16919 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115771 | 16919 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| 44309021 | 210757 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.7 | CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL69475 | 210757 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.7 | CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44303857 | 107587 | 0 | None | - | 0 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293195 | 107587 | 0 | None | - | 0 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| 24829094 | 165851 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 4.7 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| CHEMBL409722 | 165851 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 4.7 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| 15144943 | 24819 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 476 | 9 | 1 | 3 | 6.9 | CCCCc1ncc(/C=C(\Cc2ccc(Cl)c(Cl)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL126521 | 24819 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 476 | 9 | 1 | 3 | 6.9 | CCCCc1ncc(/C=C(\Cc2ccc(Cl)c(Cl)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 2121575 | 66315 | 6 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.5 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1716544 | 66315 | 6 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.5 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 24828706 | 165264 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 3.9 | CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL409095 | 165264 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 3.9 | CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44274707 | 101139 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25075 | 101139 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10482257 | 57512 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157620 | 57512 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44274707 | 101139 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL25075 | 101139 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 11527144 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL297425 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL47177 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 10482257 | 57512 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157620 | 57512 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10028993 | 123605 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 6.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337955 | 123605 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 6.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 | 10.1021/jm00100a007 | |||
| 9984807 | 125235 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL341210 | 125235 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| 131590 | 27475 | 44 | None | - | 3 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130896 | 27475 | 44 | None | - | 3 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 9984731 | 28148 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 538 | 9 | 2 | 4 | 7.3 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131433 | 28148 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 538 | 9 | 2 | 4 | 7.3 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 127029203 | 144205 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753458 | 144205 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44315057 | 211608 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 211608 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10076109 | 119632 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 12 | 0 | 7 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL330942 | 119632 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 12 | 0 | 7 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44341453 | 16456 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.1 | CCCCC1=NC2(CCC(c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113039 | 16456 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.1 | CCCCC1=NC2(CCC(c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44342048 | 117399 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 376 | 7 | 1 | 3 | 4.5 | CCCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325684 | 117399 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 376 | 7 | 1 | 3 | 4.5 | CCCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 135987615 | 107365 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 3 | 8 | 4.2 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL291689 | 107365 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 3 | 8 | 4.2 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 9933755 | 61820 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16165 | 61820 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 44293439 | 108426 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 493 | 11 | 2 | 8 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(Cc2ccccc2)n2cnnn2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299105 | 108426 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 493 | 11 | 2 | 8 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(Cc2ccccc2)n2cnnn2)cc1 | 10.1021/jm00064a007 | |||
| 15356440 | 169447 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 450 | 10 | 2 | 5 | 4.7 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(C#N)Cc2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL417009 | 169447 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 450 | 10 | 2 | 5 | 4.7 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(C#N)Cc2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| 19792151 | 108592 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300239 | 108592 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 9978845 | 137490 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL36846 | 137490 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 11167226 | 113706 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 5.7 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(O)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL314807 | 113706 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 5.7 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(O)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 3846 | 103600 | 4 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 7 | 2 | 7 | 4.3 | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26514 | 103600 | 4 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 7 | 2 | 7 | 4.3 | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956749 | 212997 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86613 | 212997 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15356431 | 108229 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 562 | 13 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297653 | 108229 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 562 | 13 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341796 | 170191 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 4.9 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL419583 | 170191 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 4.9 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44322239 | 213500 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 7 | 2 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89846 | 213500 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 7 | 2 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 11527144 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL297425 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL47177 | 185884 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44305681 | 109404 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304251 | 109404 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL5289070 | 201235 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 9800025 | 25283 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 380 | 10 | 1 | 5 | 4.5 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12737 | 25283 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 380 | 10 | 1 | 5 | 4.5 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| 10739982 | 16854 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 8 | 2 | 4 | 5.0 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| CHEMBL115393 | 16854 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 8 | 2 | 4 | 5.0 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| 10410297 | 172091 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.2 | Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL423370 | 172091 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.2 | Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 44341923 | 117102 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 10 | 2 | 5 | 4.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL323911 | 117102 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 10 | 2 | 5 | 4.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 10523819 | 200198 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL52601 | 200198 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10523819 | 200198 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL52601 | 200198 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44274741 | 100032 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24488 | 100032 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 76311804 | 91753 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 507 | 11 | 3 | 8 | 4.7 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237610 | 91753 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 507 | 11 | 3 | 8 | 4.7 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44274741 | 100032 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24488 | 100032 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 127035070 | 143250 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735931 | 143250 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10370801 | 55203 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155554 | 55203 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10077702 | 57702 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 10 | 2 | 7 | 5.1 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157779 | 57702 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 10 | 2 | 7 | 5.1 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 70686381 | 82989 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058368 | 82989 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 10573495 | 16576 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 4.0 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL113714 | 16576 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 4.0 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10764699 | 121196 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 4.2 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL333155 | 121196 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 4.2 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10078475 | 120107 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 120107 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 2541 | 7573 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 587 | 7573 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 6907 | 7573 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL1016 | 7573 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB00796 | 7573 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB13919 | 7573 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 127034038 | 145975 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3785563 | 145975 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787702 | 145975 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL5275739 | 200649 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 14951086 | 176256 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 585 | 13 | 1 | 8 | 6.2 | CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL443005 | 176256 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 585 | 13 | 1 | 8 | 6.2 | CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14956803 | 213064 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL86986 | 213064 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 15699076 | 11853 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL105486 | 11853 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 44323112 | 118420 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL328552 | 118420 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| 19792154 | 196586 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51634 | 196586 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792154 | 196586 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51634 | 196586 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792151 | 108592 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300239 | 108592 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 46232959 | 207705 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL601678 | 207705 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44274700 | 172021 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422932 | 172021 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274700 | 172021 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL422932 | 172021 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11442998 | 212970 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 479 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N(C)C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86436 | 212970 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 479 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N(C)C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 15171421 | 212995 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86604 | 212995 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 22407453 | 56532 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15671 | 56532 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL5287876 | 201178 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| 71521418 | 93605 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 597 | 7 | 1 | 8 | 6.1 | CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322447 | 93605 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 597 | 7 | 1 | 8 | 6.1 | CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76333686 | 92032 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 14 | 1 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259777 | 92032 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 14 | 1 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9980304 | 105312 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL276381 | 105312 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | |||
| 25147556 | 180642 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL453934 | 180642 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 23590374 | 210237 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 10 | 1 | 7 | 5.0 | CCCCc1nn(C/C=C/c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL65905 | 210237 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 10 | 1 | 7 | 5.0 | CCCCc1nn(C/C=C/c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 24827900 | 103640 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.8 | CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265452 | 103640 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.8 | CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 71623945 | 143242 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735839 | 143242 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10052533 | 123480 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2c(NC(=O)NC3CCCCC3)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL337269 | 123480 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2c(NC(=O)NC3CCCCC3)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44316861 | 211964 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 345 | 10 | 3 | 5 | 2.1 | CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL78345 | 211964 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 345 | 10 | 3 | 5 | 2.1 | CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44274716 | 103643 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26548 | 103643 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 11756787 | 126277 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345459 | 126277 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10053110 | 92035 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259780 | 92035 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10005890 | 121234 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333411 | 121234 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10460419 | 107109 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 5.2 | CCCCc1nc2ccn(Cc3ccccc3C(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL289448 | 107109 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 5.2 | CCCCc1nc2ccn(Cc3ccccc3C(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 10005512 | 172944 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 483 | 9 | 2 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL42631 | 172944 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 483 | 9 | 2 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 44311775 | 109791 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306923 | 109791 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311776 | 109792 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306924 | 109792 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311755 | 109911 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307866 | 109911 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311436 | 210967 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70793 | 210967 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 10408794 | 83413 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063984 | 83413 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44285178 | 107187 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.6 | CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL290180 | 107187 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.6 | CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 11502835 | 107226 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 6 | 1 | 5 | 4.8 | CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL290614 | 107226 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 6 | 1 | 5 | 4.8 | CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44210864 | 154884 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39352 | 154884 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 11756787 | 126277 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345459 | 126277 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 73346386 | 99391 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435818 | 99391 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44311739 | 109384 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304137 | 109384 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311498 | 109707 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306216 | 109707 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379182 | 64896 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167662 | 64896 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10233073 | 214412 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95198 | 214412 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 2583 | 10548 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| 592 | 10548 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| 65999 | 10548 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| 10370090 | 26479 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.2 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130095 | 26479 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.2 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10051708 | 27492 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130910 | 27492 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10052528 | 172515 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.5 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL424629 | 172515 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.5 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10140613 | 112873 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL313371 | 112873 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14956761 | 112748 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313025 | 112748 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956778 | 213072 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87057 | 213072 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277936 | 108086 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 10 | 0 | 9 | 5.7 | CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29658 | 108086 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 10 | 0 | 9 | 5.7 | CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9806554 | 172247 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccn(Cc3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL42397 | 172247 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccn(Cc3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 10053126 | 126290 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345570 | 126290 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76330043 | 92033 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 11 | 2 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259778 | 92033 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 11 | 2 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10007312 | 120062 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331519 | 120062 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10482937 | 173916 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL321086 | 173916 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL429058 | 173916 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10053126 | 126290 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345570 | 126290 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19422633 | 186401 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 432 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47428 | 186401 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 432 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44309700 | 109962 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308237 | 109962 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10078452 | 114055 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317061 | 114055 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| 10482937 | 173916 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321086 | 173916 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL429058 | 173916 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10439275 | 174839 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432392 | 174839 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 11765177 | 123786 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 123786 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44305634 | 109152 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL303822 | 109152 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 15231091 | 100763 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24861 | 100763 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10027175 | 22310 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121874 | 22310 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10075811 | 120060 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331511 | 120060 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277439 | 107228 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29063 | 107228 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 2806 | 10741 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 3937 | 10741 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 593 | 10741 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 60846 | 10741 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| DB00177 | 10741 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 10417321 | 22390 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 22390 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44305446 | 107527 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292781 | 107527 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 15229605 | 54928 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15517 | 54928 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10408794 | 83413 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063984 | 83413 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10343090 | 22306 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 10 | 1 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121854 | 22306 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 10 | 1 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035246 | 143174 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735290 | 143174 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 53309404 | 70553 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 6 | 1 | 6 | 6.4 | Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801741 | 70553 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 6 | 1 | 6 | 6.4 | Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 9853391 | 123617 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 123617 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 14956753 | 113847 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315776 | 113847 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10141821 | 106834 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL287116 | 106834 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 44379270 | 63631 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164395 | 63631 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 23590373 | 109414 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 8 | 4.0 | CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL304329 | 109414 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 8 | 4.0 | CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10078475 | 120107 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331632 | 120107 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 46910493 | 83110 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058864 | 83110 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10078475 | 120107 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 120107 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10078475 | 120107 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331632 | 120107 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 4673492 | 10910 | 9 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| 8324 | 10910 | 9 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL159096 | 10910 | 9 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| 19008869 | 213193 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL87842 | 213193 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10349791 | 118356 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328176 | 118356 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44315060 | 109834 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 109834 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44338833 | 15951 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL110265 | 15951 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277593 | 106187 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282778 | 106187 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 127029202 | 144106 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752680 | 144106 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 73357016 | 99398 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435825 | 99398 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 19939495 | 214604 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 214604 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10461595 | 214899 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97964 | 214899 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| 44211677 | 137392 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL368149 | 137392 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 11757471 | 57831 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157878 | 57831 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10414778 | 172063 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL423233 | 172063 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44311609 | 109585 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305369 | 109585 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311638 | 109702 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306186 | 109702 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 132562 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL284536 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10166561 | 16836 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL11528 | 16836 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 10475382 | 83408 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063979 | 83408 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 11757471 | 57831 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157878 | 57831 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10100625 | 58270 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158257 | 58270 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10414778 | 172063 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL423233 | 172063 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44275076 | 100590 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 546 | 8 | 1 | 6 | 7.0 | CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24764 | 100590 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 546 | 8 | 1 | 6 | 7.0 | CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10765381 | 16345 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL112414 | 16345 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 9896877 | 67006 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL174080 | 67006 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 14950497 | 92522 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 4.3 | CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL22908 | 92522 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 4.3 | CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 44308901 | 109892 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 555 | 13 | 4 | 10 | 3.2 | CCCCc1nn(CC(OCC(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C2=NNNN2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL307752 | 109892 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 555 | 13 | 4 | 10 | 3.2 | CCCCc1nn(CC(OCC(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C2=NNNN2)cc1 | 10.1021/jm00067a015 | |||
| 21840324 | 16921 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 4.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115783 | 16921 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 4.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 44270306 | 58951 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15882 | 58951 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10475382 | 83408 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063979 | 83408 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 57380415 | 77125 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 577 | 11 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945006 | 77125 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 577 | 11 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127026336 | 144052 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752160 | 144052 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 57380416 | 77126 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945007 | 77126 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 10029332 | 53667 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154083 | 53667 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 130762 | 105023 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 44285371 | 147475 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.0 | CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL38161 | 147475 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.0 | CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10029332 | 53667 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154083 | 53667 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10343457 | 24905 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2cc(OC)cs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL126921 | 24905 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2cc(OC)cs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 14950495 | 106069 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 1 | 5 | 4.1 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL281999 | 106069 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 1 | 5 | 4.1 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 | 10.1021/jm00061a016 | |||
| 15654751 | 210714 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.9 | CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69236 | 210714 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.9 | CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 5284633 | 16888 | 63 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C(=O)O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115622 | 16888 | 63 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C(=O)O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 19422652 | 117271 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 502 | 9 | 1 | 3 | 6.9 | CCCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL324888 | 117271 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 502 | 9 | 1 | 3 | 6.9 | CCCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 15144944 | 174811 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 423 | 9 | 2 | 4 | 5.2 | CCCCc1ncc(/C=C(\Cc2ccc(N)cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL432222 | 174811 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 423 | 9 | 2 | 4 | 5.2 | CCCCc1ncc(/C=C(\Cc2ccc(N)cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 11764788 | 107635 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL293501 | 107635 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10459992 | 121043 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 13 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333058 | 121043 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 13 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127034901 | 143256 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736037 | 143256 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10029368 | 126623 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348606 | 126623 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 6918269 | 105246 | 11 | None | - | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL275875 | 105246 | 11 | None | - | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL295959 | 105246 | 11 | None | - | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 132562 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL284536 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 132562 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| CHEMBL284536 | 106459 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| 9869504 | 214826 | 4 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 214826 | 4 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 11764788 | 107635 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL293501 | 107635 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL5283862 | 201010 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 76329880 | 91727 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.8 | CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237584 | 91727 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.8 | CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44323091 | 213416 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.2 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL89216 | 213416 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.2 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| 135464357 | 107334 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 6 | 2 | 7 | 4.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL291502 | 107334 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 6 | 2 | 7 | 4.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10076683 | 57091 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 8 | 1 | 7 | 4.2 | CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157203 | 57091 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 8 | 1 | 7 | 4.2 | CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9980879 | 123512 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337446 | 123512 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 | 10.1021/jm00100a007 | |||
| 44294703 | 198984 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL52046 | 198984 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44348345 | 119621 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 6 | 1 | 6 | 3.3 | CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL330866 | 119621 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 6 | 1 | 6 | 3.3 | CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80914-8 | |||
| 19889589 | 192713 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48692 | 192713 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10364310 | 25662 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 411 | 8 | 1 | 3 | 6.5 | CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128332 | 25662 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 411 | 8 | 1 | 3 | 6.5 | CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 19889589 | 192713 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48692 | 192713 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962909 | 108508 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299597 | 108508 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10346400 | 55684 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155984 | 55684 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44306613 | 210489 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL67616 | 210489 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O | 10.1016/S0960-894X(01)81148-3 | |||
| 3839 | 10529 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 60919 | 10529 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 6898 | 10529 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| CHEMBL432162 | 10529 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| DB01349 | 10529 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 10346400 | 55684 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155984 | 55684 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44438865 | 100150 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL245644 | 100150 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44297201 | 108769 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 6.2 | CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301547 | 108769 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 6.2 | CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44376747 | 126867 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350851 | 126867 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 15654755 | 110585 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 6 | 2 | 7 | 3.6 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL309084 | 110585 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 6 | 2 | 7 | 3.6 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL5276125 | 200663 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 127029201 | 144036 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751994 | 144036 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44294649 | 195868 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51001 | 195868 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 11755164 | 126496 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347513 | 126496 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11756222 | 56142 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156396 | 56142 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14962909 | 108508 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299597 | 108508 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10525501 | 108586 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL300186 | 108586 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10525501 | 108586 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL300186 | 108586 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15745369 | 16930 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 7 | 0 | 4 | 6.6 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115835 | 16930 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 7 | 0 | 4 | 6.6 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1 | 10.1021/jm00074a018 | |||
| 44322953 | 113328 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL314149 | 113328 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| 44308996 | 109750 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 5.4 | CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL306486 | 109750 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 5.4 | CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 15654746 | 210492 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 4.8 | CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL67636 | 210492 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 4.8 | CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15287888 | 107015 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.2 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL288618 | 107015 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.2 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44294207 | 108330 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 440 | 9 | 3 | 6 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)/C(=N\O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL298364 | 108330 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 440 | 9 | 3 | 6 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)/C(=N\O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| 44320536 | 213172 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 4.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2=C3C=CC=CC3N(C)C(=O)C2C(=O)O)cc1 | 10.1021/jm031100t | |||
| CHEMBL87694 | 213172 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 4.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2=C3C=CC=CC3N(C)C(=O)C2C(=O)O)cc1 | 10.1021/jm031100t | |||
| 57380413 | 77304 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947130 | 77304 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 15355268 | 108459 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299340 | 108459 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44274746 | 106446 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 591 | 7 | 3 | 8 | 5.9 | Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284455 | 106446 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 591 | 7 | 3 | 8 | 5.9 | Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10408951 | 25617 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12810 | 25617 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 14956751 | 213080 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87073 | 213080 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9824290 | 201689 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL541212 | 201689 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 10483230 | 53604 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154027 | 53604 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44438885 | 97729 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL239378 | 97729 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44315060 | 109834 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 109834 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10414301 | 28972 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 519 | 11 | 1 | 5 | 6.0 | CCCCc1nc2ccc(N(C)S(=O)(=O)CCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL132280 | 28972 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 519 | 11 | 1 | 5 | 6.0 | CCCCc1nc2ccc(N(C)S(=O)(=O)CCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44295069 | 107921 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL295369 | 107921 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10028212 | 55692 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155992 | 55692 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44293816 | 192392 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 563 | 11 | 1 | 7 | 6.5 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48640 | 192392 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 563 | 11 | 1 | 7 | 6.5 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 44307174 | 107519 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.0 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL292739 | 107519 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.0 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O | 10.1016/S0960-894X(01)81148-3 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 10028212 | 55692 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155992 | 55692 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792124 | 195038 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49980 | 195038 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 10341766 | 123855 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccsc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL339233 | 123855 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccsc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 19792124 | 195038 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49980 | 195038 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44341650 | 176666 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL444060 | 176666 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44352233 | 25707 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.0 | CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL128590 | 25707 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.0 | CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44308795 | 210690 | 0 | None | - | 0 | Bovine | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL69025 | 210690 | 0 | None | - | 0 | Bovine | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I | 10.1016/S0960-894X(01)81149-5 | |||
| 71652856 | 95919 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337684 | 95919 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365829 | 95919 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44210830 | 64257 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165850 | 64257 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 14950496 | 91793 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 5 | 1 | 5 | 4.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22391 | 91793 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 5 | 1 | 5 | 4.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 | 10.1021/jm00061a016 | |||
| 10436618 | 28454 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 517 | 8 | 1 | 5 | 5.7 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131839 | 28454 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 517 | 8 | 1 | 5 | 5.7 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44305634 | 109152 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL303822 | 109152 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 11757112 | 119746 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331081 | 119746 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44293818 | 108626 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 579 | 13 | 3 | 7 | 5.7 | CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL300487 | 108626 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 579 | 13 | 3 | 7 | 5.7 | CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 15355268 | 108459 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299340 | 108459 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962904 | 199880 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52265 | 199880 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962904 | 199880 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52265 | 199880 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034919 | 143293 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 2 | 7 | 6.6 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736310 | 143293 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 2 | 7 | 6.6 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 127034739 | 143150 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734989 | 143150 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127026058 | 144024 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 10 | 3 | 8 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751899 | 144024 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 10 | 3 | 8 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 71521298 | 93598 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 6 | 2 | 8 | 3.2 | CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322440 | 93598 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 6 | 2 | 8 | 3.2 | CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76329882 | 91732 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 538 | 12 | 2 | 8 | 5.4 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237589 | 91732 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 538 | 12 | 2 | 8 | 5.4 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19422640 | 107267 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL290988 | 107267 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44377171 | 126989 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL352042 | 126989 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 10323527 | 54800 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 5.9 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155035 | 54800 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 5.9 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 19422640 | 107267 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL290988 | 107267 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 14951061 | 211125 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 1 | 7 | 5.7 | CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL71613 | 211125 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 1 | 7 | 5.7 | CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 14952925 | 203601 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1cc(Cl)c(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL56574 | 203601 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1cc(Cl)c(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 10098291 | 22330 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 3.6 | CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121990 | 22330 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 3.6 | CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 76322687 | 91725 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 10 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237582 | 91725 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 10 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44342045 | 117153 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 488 | 7 | 1 | 3 | 7.6 | CCCCC1=NC2(CCCCCCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL324245 | 117153 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 488 | 7 | 1 | 3 | 7.6 | CCCCC1=NC2(CCCCCCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10323388 | 56082 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156352 | 56082 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 130762 | 105023 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44323113 | 213446 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 412 | 8 | 2 | 6 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL89403 | 213446 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 412 | 8 | 2 | 6 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| 76322688 | 91729 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 11 | 2 | 8 | 5.8 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237586 | 91729 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 11 | 2 | 8 | 5.8 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19010047 | 91744 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 12 | 3 | 9 | 4.9 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237601 | 91744 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 12 | 3 | 9 | 4.9 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15224461 | 26197 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 8 | 2 | 7 | 4.7 | CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL129447 | 26197 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 8 | 2 | 7 | 4.7 | CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 9986992 | 58280 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 511 | 11 | 2 | 8 | 5.3 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158267 | 58280 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 511 | 11 | 2 | 8 | 5.3 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10032191 | 126352 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 1 | 7 | 6.2 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346145 | 126352 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 1 | 7 | 6.2 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 14951090 | 109987 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 579 | 13 | 1 | 10 | 4.7 | CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL308416 | 109987 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 579 | 13 | 1 | 10 | 4.7 | CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44287123 | 106967 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 6.1 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL288222 | 106967 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 6.1 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127029204 | 144091 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752530 | 144091 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 71521503 | 93607 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322449 | 93607 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 135723833 | 205290 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.2 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL57783 | 205290 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.2 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10811315 | 117053 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.1 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL323819 | 117053 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.1 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10412363 | 27647 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL131050 | 27647 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 | 10.1021/jm00100a007 | |||
| 121879 | 9015 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| 5868 | 9015 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| CHEMBL308716 | 9015 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 127028617 | 144346 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 536 | 10 | 3 | 7 | 4.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| CHEMBL3754661 | 144346 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 536 | 10 | 3 | 7 | 4.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| 127034740 | 143269 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736166 | 143269 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035544 | 143138 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734870 | 143138 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 19029576 | 106749 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL286537 | 106749 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 10692816 | 16704 | 1 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 408 | 7 | 3 | 5 | 3.8 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL114527 | 16704 | 1 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 408 | 7 | 3 | 5 | 3.8 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 70688504 | 83111 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058865 | 83111 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71521301 | 93601 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322443 | 93601 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76308180 | 91751 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 508 | 11 | 2 | 8 | 4.7 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237608 | 91751 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 508 | 11 | 2 | 8 | 4.7 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44459780 | 98937 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24218 | 98937 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44459634 | 102915 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26048 | 102915 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44294023 | 191357 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 12 | 2 | 5 | 6.4 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2c(C)ccc2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48486 | 191357 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 12 | 2 | 5 | 6.4 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2c(C)ccc2C)cc1 | 10.1021/jm00064a007 | |||
| 10069271 | 41252 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 395 | 4 | 1 | 5 | 5.5 | Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL142860 | 41252 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 395 | 4 | 1 | 5 | 5.5 | Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10389770 | 126421 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 10 | 1 | 7 | 5.1 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346773 | 126421 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 10 | 1 | 7 | 5.1 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10252966 | 39595 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 5 | 5.7 | Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL141447 | 39595 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 5 | 5.7 | Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 127034918 | 143236 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 11 | 2 | 7 | 6.6 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| CHEMBL3735797 | 143236 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 11 | 2 | 7 | 6.6 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| 11527144 | 185884 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL297425 | 185884 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL47177 | 185884 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 44342047 | 16566 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 4.9 | CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113674 | 16566 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 4.9 | CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 3839 | 10529 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 60919 | 10529 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 6898 | 10529 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL432162 | 10529 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| DB01349 | 10529 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 9830481 | 201457 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53244 | 201457 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15287892 | 107134 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL289640 | 107134 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127035515 | 143233 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735769 | 143233 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44459856 | 103298 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 6.3 | CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26277 | 103298 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 6.3 | CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11755164 | 126496 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347513 | 126496 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127037497 | 143279 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 613 | 9 | 2 | 7 | 6.9 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736225 | 143279 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 613 | 9 | 2 | 7 | 6.9 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 73357018 | 99407 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435834 | 99407 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 24828707 | 102712 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259353 | 102712 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44377111 | 126662 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349020 | 126662 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 8374 | 9696 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 9937291 | 9696 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL34124 | 9696 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| DB16266 | 9696 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 15654759 | 210880 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 3 | 7 | 4.5 | CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70242 | 210880 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 3 | 7 | 4.5 | CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 197647 | 124864 | 6 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 4.3 | CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL340612 | 124864 | 6 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 4.3 | CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44323090 | 113346 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 6 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL314220 | 113346 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 6 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| 127028620 | 144299 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 5.3 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754198 | 144299 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 5.3 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 135723837 | 108446 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 458 | 6 | 2 | 8 | 4.9 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL299269 | 108446 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 458 | 6 | 2 | 8 | 4.9 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10027681 | 25663 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 12 | 2 | 4 | 7.4 | CCCCCNc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| CHEMBL128340 | 25663 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 12 | 2 | 4 | 7.4 | CCCCCNc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| 54768876 | 71893 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824002 | 71893 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 15654745 | 210700 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 5.1 | CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69124 | 210700 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 5.1 | CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 22850669 | 209765 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL63109 | 209765 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44274734 | 97980 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.2 | CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL23994 | 97980 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.2 | CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9955424 | 171903 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422756 | 171903 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10049809 | 120176 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331859 | 120176 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44274823 | 105851 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL280526 | 105851 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277677 | 106096 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282168 | 106096 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9955424 | 171903 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL422756 | 171903 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 19889336 | 186149 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL47382 | 186149 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 18950592 | 23562 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL124541 | 23562 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| 44285370 | 146023 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 1 | 5 | 3.9 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL37892 | 146023 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 1 | 5 | 3.9 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44209671 | 100377 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24661 | 100377 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19889336 | 186149 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL47382 | 186149 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 44379293 | 127068 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352639 | 127068 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44315350 | 111995 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 111995 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 211528 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 211528 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 44372686 | 103430 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| CHEMBL263714 | 103430 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| 14950511 | 175184 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 8 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL434768 | 175184 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 8 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 10074895 | 25882 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL128922 | 25882 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10074709 | 26300 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL129950 | 26300 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10053393 | 56793 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156934 | 56793 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956738 | 212577 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83180 | 212577 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10053393 | 56793 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156934 | 56793 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10026681 | 24711 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125940 | 24711 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10483597 | 170168 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 0 | 9 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL419421 | 170168 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 0 | 9 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44320509 | 213117 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL87327 | 213117 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9915892 | 110395 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308703 | 110395 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 9915892 | 110395 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL308703 | 110395 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 71652858 | 95929 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337677 | 95929 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365958 | 95929 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44275097 | 106109 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.4 | CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL282236 | 106109 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.4 | CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 57380414 | 77305 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947131 | 77305 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 19754062 | 109762 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306641 | 109762 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44377067 | 63337 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164059 | 63337 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10031920 | 114764 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319404 | 114764 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 123746 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 123746 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44305424 | 109270 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304032 | 109270 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 136093942 | 145872 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3786570 | 145872 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44277567 | 108174 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29725 | 108174 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44379184 | 64223 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL165541 | 64223 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 14951067 | 210274 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 489 | 12 | 1 | 9 | 3.6 | CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL66173 | 210274 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 489 | 12 | 1 | 9 | 3.6 | CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44305680 | 109525 | 0 | None | - | 0 | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 561 | 9 | 1 | 9 | 3.2 | CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305032 | 109525 | 0 | None | - | 0 | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 561 | 9 | 1 | 9 | 3.2 | CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44277937 | 108191 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29734 | 108191 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44211708 | 107456 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292316 | 107456 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10183373 | 171789 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL422593 | 171789 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277420 | 107887 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 8 | 0 | 8 | 6.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29512 | 107887 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 8 | 0 | 8 | 6.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9847539 | 188818 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47810 | 188818 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44309701 | 109963 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308238 | 109963 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10349897 | 121205 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 121205 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10350123 | 64377 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668007 | 64377 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| 10460346 | 214267 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94407 | 214267 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 | 10.1021/jm00043a020 | |||
| 10007306 | 123962 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339404 | 123962 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325483 | 23152 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 560 | 12 | 2 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122982 | 23152 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 560 | 12 | 2 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10478294 | 120887 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332766 | 120887 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956794 | 212857 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85545 | 212857 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44338834 | 14630 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL108981 | 14630 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277871 | 106476 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28464 | 106476 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277594 | 108580 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30015 | 108580 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9935096 | 214550 | 1 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9599 | 214550 | 1 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44338834 | 14630 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL108981 | 14630 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 73350991 | 99399 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435826 | 99399 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10670376 | 178826 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.5 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL447182 | 178826 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.5 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44294905 | 195928 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51084 | 195928 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 76326259 | 91749 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 598 | 12 | 2 | 10 | 4.2 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237606 | 91749 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 598 | 12 | 2 | 10 | 4.2 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44311429 | 211395 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73369 | 211395 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10053412 | 58097 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 555 | 11 | 1 | 9 | 4.6 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158115 | 58097 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 555 | 11 | 1 | 9 | 4.6 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 9909335 | 125236 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.5 | Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL341223 | 125236 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.5 | Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 44305446 | 107527 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292781 | 107527 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10369479 | 125271 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 522 | 15 | 0 | 6 | 6.0 | CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341456 | 125271 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 522 | 15 | 0 | 6 | 6.0 | CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035715 | 143218 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735652 | 143218 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 76326258 | 91746 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 2 | 9 | 2.5 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237603 | 91746 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 2 | 9 | 2.5 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44323084 | 213282 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL88350 | 213282 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| 10094614 | 56036 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 2.9 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156307 | 56036 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 2.9 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 15144940 | 124930 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 453 | 10 | 1 | 5 | 5.5 | CCCCc1ncc(/C=C(\Cc2ccc([N+](=O)[O-])cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL340825 | 124930 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 453 | 10 | 1 | 5 | 5.5 | CCCCc1ncc(/C=C(\Cc2ccc([N+](=O)[O-])cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 4110026 | 211714 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL7632 | 211714 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44298869 | 108387 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL298836 | 108387 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44298545 | 202708 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 4.5 | Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55939 | 202708 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 4.5 | Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 11167180 | 172202 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL423861 | 172202 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 71521300 | 93600 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 7 | 5.7 | CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322442 | 93600 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 7 | 5.7 | CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44438872 | 175885 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL440051 | 175885 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10391950 | 121890 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 12 | 1 | 9 | 3.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL334326 | 121890 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 12 | 1 | 9 | 3.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44307258 | 210433 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL67309 | 210433 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44341787 | 116559 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C2CCCC2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL323244 | 116559 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C2CCCC2)cc1 | 10.1021/jm00074a018 | |||
| 15780094 | 106586 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285433 | 106586 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 70684248 | 83053 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058588 | 83053 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 15699053 | 115583 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2cc(-c3nn[nH]n3)ccc12 | 10.1021/jm00114a021 | |||
| CHEMBL320951 | 115583 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2cc(-c3nn[nH]n3)ccc12 | 10.1021/jm00114a021 | |||
| 71717082 | 95924 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337683 | 95924 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365904 | 95924 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 127035069 | 143177 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735300 | 143177 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 9985434 | 57072 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157185 | 57072 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127035379 | 143285 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736248 | 143285 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 135987614 | 107476 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 7 | 3 | 8 | 4.6 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL292430 | 107476 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 7 | 3 | 8 | 4.6 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 44283480 | 107244 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290768 | 107244 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9985434 | 57072 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157185 | 57072 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44297114 | 108578 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL300105 | 108578 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44297216 | 193600 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL48934 | 193600 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14956775 | 210760 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL69508 | 210760 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 15287883 | 104986 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL274260 | 104986 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 71654382 | 95920 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337681 | 95920 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365830 | 95920 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 135415867 | 7348 | 97 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 6901 | 7348 | 97 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL57242 | 7348 | 97 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 135487973 | 205927 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 5.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL58938 | 205927 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 5.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 11511750 | 103330 | 1 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL262958 | 103330 | 1 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15698116 | 174515 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 388 | 8 | 2 | 5 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2occc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL430279 | 174515 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 388 | 8 | 2 | 5 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2occc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 24827903 | 102760 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.7 | CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259575 | 102760 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.7 | CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 14956743 | 170884 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL420970 | 170884 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44297046 | 174967 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL433278 | 174967 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14951088 | 210725 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 10 | 1 | 8 | 4.9 | CCCCc1nn(C(C)(C)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL69296 | 210725 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 10 | 1 | 8 | 4.9 | CCCCc1nn(C(C)(C)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 130762 | 105023 | 9 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00100a007 | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00100a007 | |||
| 3082918 | 101844 | 1 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL25528 | 101844 | 1 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 127028619 | 144273 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 11 | 3 | 7 | 5.3 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| CHEMBL3754010 | 144273 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 11 | 3 | 7 | 5.3 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| 10478476 | 109823 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL307191 | 109823 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 44312700 | 211515 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 6 | 3 | 8 | 2.0 | O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL74347 | 211515 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 6 | 3 | 8 | 2.0 | O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 44301981 | 107403 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL291944 | 107403 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 10478476 | 109823 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL307191 | 109823 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| 127026043 | 144131 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752947 | 144131 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44300827 | 108544 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL299897 | 108544 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44211708 | 107456 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292316 | 107456 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44307087 | 210554 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL68111 | 210554 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9843116 | 120280 | 84 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 6 | 0 | 3 | 5.5 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL332051 | 120280 | 84 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 6 | 0 | 3 | 5.5 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1021/jm00074a018 | |||
| 19792146 | 108679 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300861 | 108679 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15069407 | 196422 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51508 | 196422 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10047444 | 107123 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL289543 | 107123 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 15654700 | 170535 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 7 | 1 | 8 | 4.8 | CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL420551 | 170535 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 7 | 1 | 8 | 4.8 | CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654749 | 210609 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.2 | CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68494 | 210609 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.2 | CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 14952903 | 202354 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 380 | 9 | 1 | 4 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL55508 | 202354 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 380 | 9 | 1 | 4 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 | 10.1016/S0960-894X(01)81116-1 | |||
| 15069407 | 196422 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51508 | 196422 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792146 | 108679 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300861 | 108679 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44298808 | 108759 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.5 | CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL301479 | 108759 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.5 | CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10255888 | 83411 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063982 | 83411 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10255888 | 83411 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063982 | 83411 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44210836 | 63283 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL163523 | 63283 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 70694736 | 82988 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058367 | 82988 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| 14951085 | 109964 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 537 | 13 | 1 | 8 | 5.5 | CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL308239 | 109964 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 537 | 13 | 1 | 8 | 5.5 | CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 71521506 | 93582 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322172 | 93582 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 19792159 | 200059 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52398 | 200059 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792159 | 200059 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52398 | 200059 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44296550 | 195579 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 407 | 9 | 2 | 4 | 4.7 | CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL50592 | 195579 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 407 | 9 | 2 | 4 | 4.7 | CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL86558 | 212988 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 4.7 | CCCCN1N=C(CCC)/C(=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 10642524 | 16391 | 1 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL112637 | 16391 | 1 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 44303859 | 207770 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60209 | 207770 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 15654716 | 110562 | 0 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308911 | 110562 | 0 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10047444 | 107123 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL289543 | 107123 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 9910561 | 16819 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 4.6 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115206 | 16819 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 4.6 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 9867026 | 210707 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 424 | 6 | 2 | 6 | 4.2 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69154 | 210707 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 424 | 6 | 2 | 6 | 4.2 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10004855 | 123503 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337380 | 123503 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 | 10.1021/jm00100a007 | |||
| 10094851 | 28069 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131365 | 28069 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15699075 | 12194 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL107271 | 12194 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 10621927 | 117639 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL326086 | 117639 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10094965 | 25695 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C | 10.1021/jm00100a007 | |||
| CHEMBL128536 | 25695 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C | 10.1021/jm00100a007 | |||
| 24828708 | 166520 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410487 | 166520 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127037496 | 143181 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 12 | 2 | 7 | 6.9 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| CHEMBL3735311 | 143181 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 12 | 2 | 7 | 6.9 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| 44341792 | 117362 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 420 | 7 | 1 | 4 | 4.5 | CCCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325445 | 117362 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 420 | 7 | 1 | 4 | 4.5 | CCCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 127035067 | 143170 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735236 | 143170 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10482340 | 24417 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 4.2 | CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125835 | 24417 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 4.2 | CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325295 | 124956 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 12 | 1 | 9 | 4.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL340882 | 124956 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 12 | 1 | 9 | 4.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44295090 | 108431 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL299151 | 108431 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10343392 | 26926 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1021/jm00100a007 | |||
| CHEMBL130455 | 26926 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1021/jm00100a007 | |||
| 44309268 | 210644 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 4.8 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL68713 | 210644 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 4.8 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 76329884 | 91747 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 11 | 2 | 9 | 4.7 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237604 | 91747 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 11 | 2 | 9 | 4.7 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44210646 | 25878 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL128920 | 25878 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 10395045 | 126512 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 10 | 1 | 8 | 5.1 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347630 | 126512 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 10 | 1 | 8 | 5.1 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44317214 | 111536 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL310752 | 111536 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 10072403 | 23850 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 11 | 1 | 9 | 3.9 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cc([N+](=O)[O-])cc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12548 | 23850 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 11 | 1 | 9 | 3.9 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cc([N+](=O)[O-])cc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 11744700 | 126459 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347234 | 126459 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341608 | 117438 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 9 | 2 | 5 | 5.4 | CCCCC1=NC2(CCN(C(=O)c3ccccc3C(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325905 | 117438 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 9 | 2 | 5 | 5.4 | CCCCC1=NC2(CCN(C(=O)c3ccccc3C(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 135723851 | 107600 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 472 | 7 | 2 | 8 | 5.3 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL293308 | 107600 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 472 | 7 | 2 | 8 | 5.3 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 11744700 | 126459 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347234 | 126459 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10408577 | 28586 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131948 | 28586 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10253216 | 57493 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157597 | 57493 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10253216 | 57493 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157597 | 57493 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127035392 | 143277 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736202 | 143277 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11757293 | 126617 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL348568 | 126617 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341756 | 16733 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 5.7 | CCCCC1=NC2(CCN(C(=O)c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114720 | 16733 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 5.7 | CCCCC1=NC2(CCN(C(=O)c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 11757293 | 126617 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348568 | 126617 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14956799 | 113676 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314590 | 113676 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 130762 | 105023 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 130762 | 105023 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL274447 | 105023 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15654730 | 211019 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL71038 | 211019 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 44298546 | 107472 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 4.1 | CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL292412 | 107472 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 4.1 | CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 11785963 | 212614 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 535 | 10 | 1 | 6 | 7.2 | CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| CHEMBL83452 | 212614 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 535 | 10 | 1 | 6 | 7.2 | CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| 127036105 | 143296 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736336 | 143296 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44209951 | 98955 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24240 | 98955 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44209671 | 100377 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24661 | 100377 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274671 | 101009 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 8 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25000 | 101009 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 8 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956748 | 212752 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL84627 | 212752 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44209951 | 98955 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24240 | 98955 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 9870463 | 109026 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL303147 | 109026 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9887844 | 169979 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL418226 | 169979 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 9870463 | 109026 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL303147 | 109026 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/j.bmc.2010.10.043 | |||
| 9887844 | 169979 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL418226 | 169979 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 131654 | 213182 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL87778 | 213182 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| 44275108 | 101524 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 8 | 1 | 7 | 5.7 | CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25313 | 101524 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 8 | 1 | 7 | 5.7 | CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127035717 | 143194 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735409 | 143194 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10053595 | 109893 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307756 | 109893 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311738 | 210970 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 10 | 2 | 8 | 4.4 | CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70801 | 210970 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 10 | 2 | 8 | 4.4 | CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379334 | 64885 | 1 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167584 | 64885 | 1 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10054912 | 214411 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95197 | 214411 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| 44373417 | 59157 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| CHEMBL159004 | 59157 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| 14950508 | 106347 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL283742 | 106347 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171368 | 174845 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 | 10.1021/jm00061a016 | |||
| CHEMBL432459 | 174845 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 | 10.1021/jm00061a016 | |||
| 10480536 | 28401 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 7 | 1 | 6 | 6.3 | CCCc1nc2c(C)cc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131767 | 28401 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 7 | 1 | 6 | 6.3 | CCCc1nc2c(C)cc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10481936 | 123475 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.4 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL337232 | 123475 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.4 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 15287890 | 162550 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40585 | 162550 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44277574 | 108678 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30086 | 108678 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 15231094 | 146075 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL37919 | 146075 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 71521302 | 93602 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322444 | 93602 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 131654 | 213182 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87778 | 213182 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44348355 | 120164 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL331797 | 120164 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| 53309406 | 70555 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 511 | 6 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801743 | 70555 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 511 | 6 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 9847539 | 188818 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47810 | 188818 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 10349256 | 118233 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327569 | 118233 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| 44300615 | 203562 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL56549 | 203562 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10257584 | 23900 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 577 | 14 | 0 | 8 | 6.2 | CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125533 | 23900 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 577 | 14 | 0 | 8 | 6.2 | CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O | 10.1007/s00044-009-9205-9 | |||
| 10168097 | 179841 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 587 | 11 | 1 | 9 | 5.7 | CCCCc1nc2ccn(Cc3ccccc3C(=O)OCC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL45195 | 179841 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 587 | 11 | 1 | 9 | 5.7 | CCCCc1nc2ccn(Cc3ccccc3C(=O)OCC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 10765180 | 17017 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 7 | 3 | 7 | 3.3 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL116094 | 17017 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 7 | 3 | 7 | 3.3 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10004112 | 32302 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| CHEMBL135089 | 32302 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| 44277489 | 107189 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29020 | 107189 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 10439612 | 168634 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 688 | 10 | 1 | 7 | 6.8 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 | 10.1021/jm00043a020 | |||
| CHEMBL414816 | 168634 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 688 | 10 | 1 | 7 | 6.8 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 | 10.1021/jm00043a020 | |||
| 10439172 | 214262 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94355 | 214262 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| 14956758 | 113308 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314042 | 113308 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9931685 | 212863 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL85595 | 212863 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 9931685 | 212863 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL85595 | 212863 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | |||
| 44379335 | 126999 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352137 | 126999 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379348 | 171700 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL422374 | 171700 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10160805 | 210843 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 445 | 11 | 1 | 7 | 4.5 | CCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| CHEMBL70029 | 210843 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 445 | 11 | 1 | 7 | 4.5 | CCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 14956769 | 113893 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL316052 | 113893 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277443 | 107074 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28918 | 107074 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44310609 | 210532 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL67919 | 210532 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 10008962 | 126051 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343719 | 126051 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10369701 | 23067 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 0 | 7 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122494 | 23067 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 0 | 7 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956762 | 105606 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL278741 | 105606 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956762 | 105606 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278741 | 105606 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44377123 | 126753 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349856 | 126753 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10100723 | 214227 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94176 | 214227 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44315282 | 103399 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 103399 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 10008962 | 126051 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343719 | 126051 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44379217 | 64923 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167929 | 64923 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10416957 | 118276 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327791 | 118276 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10372810 | 112979 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 112979 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 135723852 | 145918 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787050 | 145918 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44274745 | 98564 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 633 | 8 | 3 | 8 | 6.3 | CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24111 | 98564 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 633 | 8 | 3 | 8 | 6.3 | CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10370801 | 55203 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155554 | 55203 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127035082 | 143289 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736262 | 143289 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 9984390 | 126319 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 11 | 1 | 8 | 4.8 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345826 | 126319 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 11 | 1 | 8 | 4.8 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 9888820 | 16739 | 36 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 428 | 8 | 2 | 6 | 4.5 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| CHEMBL114752 | 16739 | 36 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 428 | 8 | 2 | 6 | 4.5 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| 44376992 | 63894 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 4.1 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164552 | 63894 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 4.1 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9953638 | 91831 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 7 | 3.9 | COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL22426 | 91831 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 7 | 3.9 | COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 9887844 | 169979 | 4 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm00061a016 | |||
| CHEMBL418226 | 169979 | 4 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm00061a016 | |||
| 14956802 | 213094 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87184 | 213094 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 19385729 | 57653 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15774 | 57653 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15356434 | 108503 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 590 | 13 | 1 | 8 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299557 | 108503 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 590 | 13 | 1 | 8 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 9869596 | 122042 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 8 | 5.1 | CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL334838 | 122042 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 8 | 5.1 | CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44321050 | 213023 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 416 | 9 | 1 | 5 | 4.5 | CCCCN1N=C(CCC)C(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL86764 | 213023 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 416 | 9 | 1 | 5 | 4.5 | CCCCN1N=C(CCC)C(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 15144942 | 123779 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 9 | 1 | 3 | 5.9 | CCCCc1ncc(/C=C(\Cc2ccccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL338813 | 123779 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 9 | 1 | 3 | 5.9 | CCCCc1ncc(/C=C(\Cc2ccccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 71653009 | 95930 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337685 | 95930 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366019 | 95930 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 127035557 | 143209 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735558 | 143209 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44306646 | 209793 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63280 | 209793 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 10646584 | 17029 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL116102 | 17029 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 22850667 | 207579 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60071 | 207579 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10050519 | 105285 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.3 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(Cl)cc(Cl)c3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL276150 | 105285 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.3 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(Cl)cc(Cl)c3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 11477098 | 213003 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 5 | 1 | 8 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c3nnnn3c3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86655 | 213003 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 5 | 1 | 8 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c3nnnn3c3ccccc23)cc1 | 10.1021/jm031100t | |||
| 19422629 | 105175 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(CC)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL275437 | 105175 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(CC)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 57380213 | 77302 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947128 | 77302 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44305654 | 107559 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL293001 | 107559 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10071111 | 126419 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL346742 | 126419 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341786 | 172081 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 5 | 1 | 3 | 5.2 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2c2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL423325 | 172081 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 5 | 1 | 3 | 5.2 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2c2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| 10071111 | 126419 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346742 | 126419 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24827772 | 102563 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.3 | CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL258685 | 102563 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.3 | CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44297144 | 174796 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL432128 | 174796 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44288321 | 161978 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL40250 | 161978 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 127026042 | 144035 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 620 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751986 | 144035 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 620 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127036867 | 144160 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753134 | 144160 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15287884 | 162020 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40273 | 162020 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 15171420 | 213468 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89614 | 213468 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44352199 | 28777 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 7 | 1 | 6 | 5.0 | CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL132109 | 28777 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 7 | 1 | 6 | 5.0 | CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 14950504 | 92265 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| CHEMBL22692 | 92265 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| 10052319 | 170114 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 12 | 1 | 7 | 4.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL419058 | 170114 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 12 | 1 | 7 | 4.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9807638 | 193925 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49192 | 193925 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 11743916 | 126240 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 439 | 10 | 1 | 7 | 4.3 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345127 | 126240 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 439 | 10 | 1 | 7 | 4.3 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792121 | 196218 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51340 | 196218 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10363552 | 27387 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2ccc(N)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130828 | 27387 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2ccc(N)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15699068 | 12136 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| CHEMBL106934 | 12136 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| 44303884 | 209612 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62422 | 209612 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44459611 | 106867 | 0 | None | - | 0 | Bovine | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 5.9 | COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL287374 | 106867 | 0 | None | - | 0 | Bovine | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 5.9 | COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 19792121 | 196218 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51340 | 196218 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127036868 | 144141 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753007 | 144141 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 10001717 | 55030 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 412 | 7 | 1 | 7 | 4.1 | CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155305 | 55030 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 412 | 7 | 1 | 7 | 4.1 | CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9985840 | 126801 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 426 | 8 | 1 | 7 | 4.3 | CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350241 | 126801 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 426 | 8 | 1 | 7 | 4.3 | CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9930953 | 109579 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305350 | 109579 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 3025727 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL48242 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 3025727 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48242 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44358531 | 126139 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 636 | 6 | 3 | 8 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL344388 | 126139 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 636 | 6 | 3 | 8 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 3025727 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL48242 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 3025727 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48242 | 190859 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44459759 | 106460 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 568 | 7 | 2 | 8 | 5.5 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL284546 | 106460 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 568 | 7 | 2 | 8 | 5.5 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 15662012 | 196108 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51246 | 196108 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15699052 | 116552 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cccc(-c3nn[nH]n3)c2c1 | 10.1021/jm00114a021 | |||
| CHEMBL323179 | 116552 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cccc(-c3nn[nH]n3)c2c1 | 10.1021/jm00114a021 | |||
| 44291477 | 108123 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL296883 | 108123 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 9888865 | 64271 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165974 | 64271 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 127035084 | 143161 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 707 | 13 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735151 | 143161 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 707 | 13 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 44291477 | 108123 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL296883 | 108123 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 18942290 | 200395 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 558 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52700 | 200395 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 558 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15654747 | 210611 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.4 | CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68516 | 210611 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.4 | CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15662012 | 196108 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51246 | 196108 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 76315365 | 91723 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 11 | 3 | 8 | 4.0 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237580 | 91723 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 11 | 3 | 8 | 4.0 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10078057 | 57408 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 492 | 10 | 2 | 7 | 4.4 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157512 | 57408 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 492 | 10 | 2 | 7 | 4.4 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44358303 | 37649 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL139739 | 37649 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 15287887 | 151970 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 7 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL39124 | 151970 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 7 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127034920 | 143309 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736451 | 143309 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 46910582 | 77128 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945009 | 77128 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127036107 | 143294 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736319 | 143294 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 9940350 | 211537 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL74573 | 211537 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 10072002 | 122021 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2c(NC(C)=O)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL334741 | 122021 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2c(NC(C)=O)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 11328411 | 112944 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL313718 | 112944 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 10786794 | 169671 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL417366 | 169671 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10786794 | 169671 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL417366 | 169671 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15654757 | 109004 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 494 | 7 | 2 | 7 | 4.6 | O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL302973 | 109004 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 494 | 7 | 2 | 7 | 4.6 | O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 15654752 | 109031 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.8 | COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303170 | 109031 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.8 | COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44295010 | 194023 | 0 | None | - | 1 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49262 | 194023 | 0 | None | - | 1 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 54768877 | 71894 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 535 | 9 | 1 | 8 | 5.2 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824003 | 71894 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 535 | 9 | 1 | 8 | 5.2 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 14951089 | 109720 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 583 | 12 | 1 | 8 | 6.0 | CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL306328 | 109720 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 583 | 12 | 1 | 8 | 6.0 | CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44341597 | 16731 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 9 | 2 | 5 | 3.8 | CCCCC1=NC2(CCN(C(=O)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114710 | 16731 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 9 | 2 | 5 | 3.8 | CCCCC1=NC2(CCN(C(=O)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44315350 | 111995 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 111995 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10275744 | 212897 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL85876 | 212897 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44293656 | 194792 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 514 | 13 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](CCCC)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49748 | 194792 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 514 | 13 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](CCCC)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 15780089 | 106585 | 0 | None | - | 0 | Rabbit | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285432 | 106585 | 0 | None | - | 0 | Rabbit | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44303887 | 210100 | 0 | None | - | 0 | Rabbit | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64861 | 210100 | 0 | None | - | 0 | Rabbit | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 71521194 | 93587 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 4 | 2 | 6 | 3.7 | CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322177 | 93587 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 4 | 2 | 6 | 3.7 | CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 24828038 | 166234 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 7 | 1 | 6 | 4.5 | CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410125 | 166234 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 7 | 1 | 6 | 4.5 | CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19087866 | 105712 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL279515 | 105712 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956801 | 212889 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85765 | 212889 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 60165459 | 112028 | 7 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 10 | 1 | 7 | 7.7 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115247 | 112028 | 7 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 10 | 1 | 7 | 7.7 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| 44277594 | 108580 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30015 | 108580 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44306651 | 107316 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 3 | 1 | 4 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL291358 | 107316 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 3 | 1 | 4 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 3081289 | 16796 | 11 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL115021 | 16796 | 11 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 6918269 | 105246 | 11 | None | 776 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL275875 | 105246 | 11 | None | 776 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL295959 | 105246 | 11 | None | 776 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 19771826 | 213404 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89143 | 213404 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 9895957 | 17445 | 18 | None | -5 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
| CHEMBL11706 | 17445 | 18 | None | -5 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 108185 | 8395 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| 586 | 8395 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| 15236334 | 172379 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL424289 | 172379 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 108185 | 8395 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 586 | 8395 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| CHEMBL907 | 8395 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 10394727 | 109839 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307321 | 109839 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311650 | 109978 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308361 | 109978 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311607 | 210962 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70770 | 210962 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222103 | 211318 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72819 | 211318 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 3081289 | 16796 | 11 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL115021 | 16796 | 11 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44376760 | 172173 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 11 | 3 | 6 | 4.7 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL423801 | 172173 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 11 | 3 | 6 | 4.7 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 14950498 | 105800 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 7 | 1 | 6 | 5.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL280189 | 105800 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 7 | 1 | 6 | 5.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 14950505 | 105933 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 433 | 6 | 1 | 5 | 5.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL281192 | 105933 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 433 | 6 | 1 | 5 | 5.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 44341922 | 17189 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 2 | 5 | 3.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL116298 | 17189 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 2 | 5 | 3.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 9888876 | 55764 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15606 | 55764 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10437754 | 126487 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347404 | 126487 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76319527 | 92179 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 11 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263317 | 92179 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 11 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10437754 | 126487 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347404 | 126487 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10394859 | 24201 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 24201 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 127029976 | 145995 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786145 | 145995 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787767 | 145995 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 44376781 | 63046 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162859 | 63046 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44305663 | 107776 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294358 | 107776 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 127034922 | 143141 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734891 | 143141 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44274823 | 105851 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL280526 | 105851 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10076191 | 125229 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 548 | 13 | 0 | 6 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341151 | 125229 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 548 | 13 | 0 | 6 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277874 | 106330 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 629 | 11 | 0 | 9 | 6.9 | CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28359 | 106330 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 629 | 11 | 0 | 9 | 6.9 | CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44459903 | 106278 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.3 | CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL283292 | 106278 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.3 | CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 9931685 | 212863 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL85595 | 212863 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 44277481 | 108348 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 647 | 9 | 1 | 9 | 5.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29853 | 108348 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 647 | 9 | 1 | 9 | 5.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9932483 | 214622 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9642 | 214622 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44358381 | 36132 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 6 | 2 | 8 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL138358 | 36132 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 6 | 2 | 8 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 19029589 | 125546 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 6 | 1 | 7 | 3.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2CC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL34190 | 125546 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 6 | 1 | 7 | 3.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2CC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 76311802 | 91738 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237595 | 91738 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10048770 | 125172 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341070 | 125172 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956740 | 212587 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83248 | 212587 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9984360 | 126398 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346542 | 126398 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44277574 | 108678 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30086 | 108678 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 10053499 | 55565 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155877 | 55565 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10482258 | 126453 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347135 | 126453 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9888159 | 113743 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cn2)n1 | 10.1021/jm031100t | |||
| CHEMBL315022 | 113743 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cn2)n1 | 10.1021/jm031100t | |||
| 44348259 | 22804 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122367 | 22804 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 10053499 | 55565 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155877 | 55565 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10482258 | 126453 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347135 | 126453 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 71520500 | 93585 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 6 | 1 | 7 | 5.8 | CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322175 | 93585 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 6 | 1 | 7 | 5.8 | CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 53309274 | 70550 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.2 | CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801738 | 70550 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.2 | CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 44277442 | 107073 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28917 | 107073 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 132706 | 8457 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| 6896 | 8457 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| CHEMBL315021 | 8457 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| DB01342 | 8457 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| 10344235 | 212939 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86247 | 212939 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 132706 | 8457 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| 6896 | 8457 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL315021 | 8457 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| DB01342 | 8457 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| 10344235 | 212939 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm7011563 | |||
| CHEMBL86247 | 212939 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm7011563 | |||
| 15224471 | 161612 | 0 | None | - | 1 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL400424 | 161612 | 0 | None | - | 1 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10645687 | 16944 | 0 | None | - | 0 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115946 | 16944 | 0 | None | - | 0 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10368143 | 53533 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL153968 | 53533 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10459507 | 54499 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154772 | 54499 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956775 | 210760 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL69508 | 210760 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 76310610 | 112027 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 10 | 1 | 5 | 8.2 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115246 | 112027 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 10 | 1 | 5 | 8.2 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| 44293815 | 191026 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 549 | 11 | 2 | 6 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48363 | 191026 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 549 | 11 | 2 | 6 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341824 | 16788 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.5 | CCCCC1=NC2(Cc3ccccc3C2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114983 | 16788 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.5 | CCCCC1=NC2(Cc3ccccc3C2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19889356 | 186676 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL47459 | 186676 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 44348332 | 22308 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL121871 | 22308 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 44348323 | 23230 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL123348 | 23230 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC | 10.1016/S0960-894X(01)80914-8 | |||
| 10368143 | 53533 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL153968 | 53533 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10459507 | 54499 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154772 | 54499 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19889356 | 186676 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL47459 | 186676 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10642523 | 117243 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL324729 | 117243 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 9982103 | 121933 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL334431 | 121933 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 | 10.1021/jm00100a007 | |||
| 44341924 | 18097 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 2 | 5 | 5.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL117941 | 18097 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 2 | 5 | 5.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 11561462 | 117910 | 61 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 4.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL326349 | 117910 | 61 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 4.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 15287885 | 168594 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41440 | 168594 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 15699054 | 116262 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| CHEMBL322071 | 116262 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| 24828034 | 173209 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 3.7 | CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL427738 | 173209 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 3.7 | CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19792191 | 105154 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL275304 | 105154 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10503729 | 16457 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 9 | 2 | 6 | 4.7 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL113040 | 16457 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 9 | 2 | 6 | 4.7 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 11741515 | 123621 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 7 | 1 | 3 | 6.1 | CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL338048 | 123621 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 7 | 1 | 3 | 6.1 | CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 21840429 | 117697 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 393 | 9 | 2 | 5 | 3.1 | CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL326140 | 117697 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 393 | 9 | 2 | 5 | 3.1 | CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81117-3 | |||
| 44298570 | 107791 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL294485 | 107791 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44298809 | 202292 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 6 | 1 | 7 | 4.2 | Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55366 | 202292 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 6 | 1 | 7 | 4.2 | Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 19792191 | 105154 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL275304 | 105154 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 18572337 | 87932 | 9 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 419 | 6 | 0 | 9 | 3.5 | O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl | 10.1016/j.bmcl.2012.08.105 | |||
| CHEMBL2158005 | 87932 | 9 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 419 | 6 | 0 | 9 | 3.5 | O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl | 10.1016/j.bmcl.2012.08.105 | |||
| 127035248 | 143219 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735653 | 143219 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 9937461 | 108600 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL300279 | 108600 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127035263 | 143238 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735804 | 143238 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44341836 | 117190 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 470 | 7 | 1 | 3 | 6.2 | CCCCC1=NC2(C(=O)N1Cc1ccc(-c3ccccc3C(=O)O)cc1)C1CC3CC(C1)CC2C3 | 10.1021/jm00074a018 | |||
| CHEMBL324452 | 117190 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 470 | 7 | 1 | 3 | 6.2 | CCCCC1=NC2(C(=O)N1Cc1ccc(-c3ccccc3C(=O)O)cc1)C1CC3CC(C1)CC2C3 | 10.1021/jm00074a018 | |||
| 15654703 | 211087 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 4.1 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71410 | 211087 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 4.1 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44305663 | 107776 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294358 | 107776 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385598 | 105638 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278955 | 105638 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| 135723843 | 107734 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 468 | 8 | 2 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL294140 | 107734 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 468 | 8 | 2 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 15654753 | 211006 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.5 | CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70947 | 211006 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.5 | CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 127035393 | 143169 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735227 | 143169 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 76315369 | 91752 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 522 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237609 | 91752 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 522 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10005344 | 53945 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 1 | 7 | 5.1 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154315 | 53945 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 1 | 7 | 5.1 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44320816 | 213053 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 414 | 10 | 1 | 5 | 5.5 | CCCCc1cn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CCCC)n1 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL86935 | 213053 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 414 | 10 | 1 | 5 | 5.5 | CCCCc1cn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CCCC)n1 | 10.1016/S0960-894X(01)80290-0 | |||
| 71521585 | 93584 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 6 | 1 | 9 | 4.8 | CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322174 | 93584 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 6 | 1 | 9 | 4.8 | CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 71521505 | 93610 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322451 | 93610 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 70684421 | 83409 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063980 | 83409 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 9979266 | 124071 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 379 | 5 | 1 | 5 | 4.7 | c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 | 10.1021/jm00100a007 | |||
| CHEMBL339592 | 124071 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 379 | 5 | 1 | 5 | 4.7 | c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 | 10.1021/jm00100a007 | |||
| 70684421 | 83409 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063980 | 83409 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 71654380 | 95932 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337680 | 95932 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366021 | 95932 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44315344 | 111858 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 111858 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19036230 | 108531 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 5 | 3.8 | CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL299809 | 108531 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 5 | 3.8 | CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15287883 | 104986 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL274260 | 104986 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 15654760 | 108969 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 9 | 3 | 7 | 4.8 | CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302811 | 108969 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 9 | 3 | 7 | 4.8 | CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44342002 | 16721 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 5.9 | CCCCC1=NC2(CCC(C)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114656 | 16721 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 5.9 | CCCCC1=NC2(CCC(C)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 11352388 | 112722 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 6.4 | CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| CHEMBL312889 | 112722 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 6.4 | CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| 9983514 | 26253 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL129872 | 26253 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 | 10.1021/jm00100a007 | |||
| 15654696 | 110556 | 65 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 7 | 1 | 8 | 4.1 | CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308884 | 110556 | 65 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 7 | 1 | 8 | 4.1 | CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44341698 | 166715 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL410724 | 166715 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00074a018 | |||
| 44295673 | 169558 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL417196 | 169558 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44295673 | 169558 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL417196 | 169558 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44305289 | 210056 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 2.7 | CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL64670 | 210056 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 2.7 | CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 18654313 | 70544 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801713 | 70544 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 15171411 | 212981 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86495 | 212981 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 71521419 | 93606 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322448 | 93606 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 127026041 | 144308 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754267 | 144308 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44293911 | 195021 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 11 | 2 | 6 | 5.9 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49954 | 195021 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 11 | 2 | 6 | 5.9 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| 127035381 | 143251 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735940 | 143251 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 14956800 | 212929 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86143 | 212929 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 22850890 | 196553 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL51606 | 196553 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44294562 | 195925 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51078 | 195925 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44563175 | 195872 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 570 | 7 | 1 | 5 | 8.6 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL510065 | 195872 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 570 | 7 | 1 | 5 | 8.6 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 14956746 | 212973 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86440 | 212973 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44270285 | 105841 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280456 | 105841 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 127026040 | 144257 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 11 | 3 | 8 | 4.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753888 | 144257 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 11 | 3 | 8 | 4.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44298833 | 205288 | 0 | None | - | 0 | Bovine | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 482 | 7 | 2 | 8 | 3.6 | CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL57781 | 205288 | 0 | None | - | 0 | Bovine | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 482 | 7 | 2 | 8 | 3.6 | CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 127035249 | 143299 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736346 | 143299 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44274733 | 106183 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 8 | 1 | 7 | 5.4 | CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL282746 | 106183 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 8 | 1 | 7 | 5.4 | CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 15171415 | 113715 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL314859 | 113715 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 127035757 | 143283 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736242 | 143283 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 71520501 | 93586 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 552 | 6 | 1 | 8 | 5.4 | CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322176 | 93586 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 552 | 6 | 1 | 8 | 5.4 | CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44376991 | 127073 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL352675 | 127073 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10075750 | 114335 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318891 | 114335 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 9851889 | 108851 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 108851 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 19010079 | 91731 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 524 | 11 | 2 | 8 | 5.4 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237588 | 91731 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 524 | 11 | 2 | 8 | 5.4 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10367792 | 24713 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125958 | 24713 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9981102 | 170971 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421074 | 170971 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10096735 | 126308 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 1 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345717 | 126308 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 1 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44277873 | 105648 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 11 | 0 | 10 | 5.5 | CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL27903 | 105648 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 11 | 0 | 10 | 5.5 | CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44342039 | 17065 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL116170 | 17065 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19029573 | 127497 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 405 | 5 | 1 | 7 | 2.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(C)=O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL35475 | 127497 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 405 | 5 | 1 | 7 | 2.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(C)=O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 44314780 | 109855 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 109855 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 127034921 | 143306 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736440 | 143306 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44291781 | 188337 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 8 | 1 | 3 | 5.4 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47669 | 188337 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 8 | 1 | 3 | 5.4 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 11757193 | 58123 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158133 | 58123 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 2806 | 10741 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 3937 | 10741 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 593 | 10741 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 60846 | 10741 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| DB00177 | 10741 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 11757193 | 58123 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158133 | 58123 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44379269 | 63942 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164769 | 63942 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376779 | 63277 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 3 | 6 | 3.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163485 | 63277 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 3 | 6 | 3.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44277549 | 105904 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280988 | 105904 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44300637 | 107702 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293949 | 107702 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10436523 | 126241 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345139 | 126241 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10436523 | 126241 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345139 | 126241 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44274716 | 103643 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26548 | 103643 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 54178446 | 70543 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801712 | 70543 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 44291782 | 190196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47985 | 190196 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 14956755 | 112926 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313579 | 112926 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10202093 | 213214 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87985 | 213214 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 11443112 | 113408 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.6 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL314315 | 113408 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.6 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 158781 | 50940 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1516 | 50940 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10048120 | 126270 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 4.4 | CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345404 | 126270 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 4.4 | CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 14951059 | 213208 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87942 | 213208 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10346399 | 54357 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154640 | 54357 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11758329 | 123693 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 12 | 0 | 8 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338431 | 123693 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 12 | 0 | 8 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956776 | 112745 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313017 | 112745 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10346399 | 54357 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154640 | 54357 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24828705 | 164481 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 7 | 1 | 7 | 4.0 | CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL408188 | 164481 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 7 | 1 | 7 | 4.0 | CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127036108 | 143156 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735098 | 143156 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10368898 | 25669 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 9 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128389 | 25669 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 9 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 | 10.1021/jm00100a007 | |||
| 9932352 | 23686 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2ccc(C)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL125212 | 23686 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2ccc(C)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 44341797 | 117416 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 362 | 4 | 1 | 3 | 4.1 | CC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325751 | 117416 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 362 | 4 | 1 | 3 | 4.1 | CC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44274706 | 103527 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 518 | 8 | 2 | 6 | 5.5 | CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL26449 | 103527 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 518 | 8 | 2 | 6 | 5.5 | CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 | 10.1016/S0960-894X(01)80348-6 | |||
| 71653750 | 95926 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337679 | 95926 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365906 | 95926 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44289028 | 107960 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL295646 | 107960 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10320063 | 24914 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 10 | 1 | 7 | 4.1 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(F)ccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12693 | 24914 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 10 | 1 | 7 | 4.1 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(F)ccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 76329881 | 91728 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 490 | 11 | 2 | 8 | 4.9 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237585 | 91728 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 490 | 11 | 2 | 8 | 4.9 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15780085 | 124928 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL34082 | 124928 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9981071 | 126245 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 10 | 1 | 7 | 5.3 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345181 | 126245 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 10 | 1 | 7 | 5.3 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10345129 | 55891 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156181 | 55891 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10345129 | 55891 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156181 | 55891 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792156 | 196774 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51712 | 196774 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792156 | 196774 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51712 | 196774 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 71611145 | 191641 | 2 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4852514 | 191641 | 2 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 127036866 | 144047 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752117 | 144047 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127028930 | 144082 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752444 | 144082 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44341488 | 16250 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 532 | 10 | 2 | 5 | 4.7 | CCCCC1=NC2(CCN(C(=O)C(N)C(C)CC)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL111968 | 16250 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 532 | 10 | 2 | 5 | 4.7 | CCCCC1=NC2(CCN(C(=O)C(N)C(C)CC)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10455288 | 23626 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2sccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL124859 | 23626 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2sccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 127034904 | 143241 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735831 | 143241 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11155548 | 213197 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(OC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL87884 | 213197 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(OC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 15069406 | 108525 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299753 | 108525 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15069406 | 108525 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299753 | 108525 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 53309405 | 70554 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801742 | 70554 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 10323718 | 126305 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345696 | 126305 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10323718 | 126305 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345696 | 126305 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127035380 | 143304 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736414 | 143304 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 24827904 | 103211 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL262098 | 103211 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44297202 | 108527 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 623 | 9 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL299770 | 108527 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 623 | 9 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44292497 | 21552 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL1206677 | 21552 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL295174 | 21552 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 44287133 | 144387 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL37565 | 144387 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 10457332 | 58195 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158196 | 58195 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10457332 | 58195 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158196 | 58195 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 46910581 | 83109 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058863 | 83109 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10416836 | 114681 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319313 | 114681 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| 70690562 | 83102 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058856 | 83102 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 76319036 | 91755 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 537 | 12 | 3 | 9 | 4.7 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237612 | 91755 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 537 | 12 | 3 | 9 | 4.7 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44307107 | 105471 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL277614 | 105471 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 10435850 | 55385 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 11 | 2 | 8 | 5.1 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155724 | 55385 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 11 | 2 | 8 | 5.1 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 127035391 | 143189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735390 | 143189 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 14956774 | 213017 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86741 | 213017 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15780095 | 105371 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL276853 | 105371 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44297217 | 108346 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 10 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298509 | 108346 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 10 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 135723817 | 107546 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 8 | 2 | 8 | 5.0 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL292914 | 107546 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 8 | 2 | 8 | 5.0 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 44274692 | 103221 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26217 | 103221 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10324870 | 120090 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 12 | 0 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331546 | 120090 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 12 | 0 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 11758341 | 124061 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339544 | 124061 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44306652 | 210121 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 3 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL64983 | 210121 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 3 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44311584 | 109557 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305239 | 109557 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 19771800 | 213159 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL87603 | 213159 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 20747575 | 105200 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 12 | 2 | 8 | 5.0 | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 | 10.1039/C4MD00499J | |||
| CHEMBL275545 | 105200 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 12 | 2 | 8 | 5.0 | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 | 10.1039/C4MD00499J | |||
| 127035085 | 143210 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 12 | 2 | 7 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735574 | 143210 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 12 | 2 | 7 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 44285327 | 175380 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 1 | 6 | 3.6 | CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL435953 | 175380 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 1 | 6 | 3.6 | CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311496 | 211023 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71069 | 211023 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379350 | 127563 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355443 | 127563 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 9843950 | 107347 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 8 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL291582 | 107347 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 8 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 14950510 | 92470 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22879 | 92470 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171369 | 106242 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 | 10.1021/jm00061a016 | |||
| CHEMBL283110 | 106242 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 | 10.1021/jm00061a016 | |||
| 10345638 | 27284 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 5.4 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130746 | 27284 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 5.4 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 19385601 | 58690 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 1 | 5 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15860 | 58690 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 1 | 5 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl | 10.1016/0960-894X(95)00185-V | |||
| 158781 | 50940 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1516 | 50940 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 158781 | 50940 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| CHEMBL1516 | 50940 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| 9874508 | 211459 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 211459 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10223724 | 212536 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL82797 | 212536 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 53309271 | 70547 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 4 | 1 | 6 | 5.3 | Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801735 | 70547 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 4 | 1 | 6 | 5.3 | Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 10414273 | 121325 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 518 | 12 | 0 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333722 | 121325 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 518 | 12 | 0 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277872 | 103341 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 13 | 0 | 9 | 7.7 | CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL263038 | 103341 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 13 | 0 | 9 | 7.7 | CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10256564 | 23038 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 12 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122458 | 23038 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 12 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10391038 | 123710 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338514 | 123710 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694737 | 82993 | 0 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058372 | 82993 | 0 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44342046 | 117325 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325201 | 117325 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10226439 | 210655 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 459 | 12 | 1 | 7 | 4.9 | CCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| CHEMBL68760 | 210655 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 459 | 12 | 1 | 7 | 4.9 | CCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| 44376822 | 126831 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350493 | 126831 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10439858 | 23633 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 23633 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44384872 | 66769 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173455 | 66769 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 76322692 | 91748 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 585 | 12 | 2 | 10 | 4.3 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237605 | 91748 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 585 | 12 | 2 | 10 | 4.3 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10392565 | 175192 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 542 | 11 | 1 | 9 | 4.7 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL434844 | 175192 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 542 | 11 | 1 | 9 | 4.7 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44274824 | 106039 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL281846 | 106039 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956747 | 212753 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL84630 | 212753 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15356433 | 190783 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 548 | 12 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48195 | 190783 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 548 | 12 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341802 | 118143 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCC2)C(=S)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL327018 | 118143 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCC2)C(=S)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19422646 | 176223 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL44268 | 176223 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19422646 | 176223 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL44268 | 176223 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 15287893 | 168732 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 14 | 1 | 6 | 6.9 | CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41566 | 168732 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 14 | 1 | 6 | 6.9 | CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O | 10.1016/0960-894X(94)00476-V | |||
| 44293697 | 107027 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 596 | 13 | 1 | 9 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL288753 | 107027 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 596 | 13 | 1 | 9 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 44341607 | 16818 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 534 | 10 | 3 | 6 | 3.1 | CCCCC1=NC2(CCN(C(=O)C(N)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115204 | 16818 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 534 | 10 | 3 | 6 | 3.1 | CCCCC1=NC2(CCN(C(=O)C(N)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 15654754 | 108855 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 3.3 | CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302127 | 108855 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 3.3 | CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 11756569 | 123251 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cc(NC(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL336130 | 123251 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cc(NC(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 127035083 | 143134 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734835 | 143134 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 24827901 | 166207 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410105 | 166207 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 11754954 | 175171 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 8 | 1 | 4 | 6.3 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL434640 | 175171 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 8 | 1 | 4 | 6.3 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 71521504 | 93609 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322450 | 93609 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44309398 | 109042 | 0 | None | - | 0 | Bovine | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 546 | 6 | 1 | 3 | 5.5 | CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL303247 | 109042 | 0 | None | - | 0 | Bovine | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 546 | 6 | 1 | 3 | 5.5 | CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44320733 | 213234 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 386 | 5 | 1 | 5 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| CHEMBL88081 | 213234 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 386 | 5 | 1 | 5 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| 127036865 | 144202 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753406 | 144202 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15654743 | 174934 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 6 | 2 | 6 | 4.8 | CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL433099 | 174934 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 6 | 2 | 6 | 4.8 | CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44283175 | 127148 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35324 | 127148 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10028815 | 214874 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97783 | 214874 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| 10250336 | 25658 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL128318 | 25658 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44310590 | 211147 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL71730 | 211147 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 44305654 | 107559 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL293001 | 107559 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 71653748 | 95925 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337678 | 95925 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365905 | 95925 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44293406 | 191646 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 458 | 10 | 2 | 7 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)Cn2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48526 | 191646 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 458 | 10 | 2 | 7 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)Cn2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 15654744 | 108924 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 6 | 2 | 6 | 4.5 | O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL302520 | 108924 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 6 | 2 | 6 | 4.5 | O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 10502342 | 175854 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL439743 | 175854 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10502342 | 175854 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL439743 | 175854 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44287536 | 168704 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 381 | 9 | 1 | 5 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41534 | 168704 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 381 | 9 | 1 | 5 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 76328690 | 112023 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 7.7 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115242 | 112023 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 7.7 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44315059 | 211491 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 211491 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44307257 | 109377 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 326 | 4 | 1 | 6 | 3.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL304116 | 109377 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 326 | 4 | 1 | 6 | 3.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 135723836 | 107817 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 8 | 2 | 8 | 5.7 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL294598 | 107817 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 8 | 2 | 8 | 5.7 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 15654733 | 211116 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 8 | 4.3 | C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71550 | 211116 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 8 | 4.3 | C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10250278 | 27106 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130600 | 27106 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15288898 | 211058 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 280 | 5 | 1 | 3 | 4.1 | CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL71254 | 211058 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 280 | 5 | 1 | 3 | 4.1 | CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44303883 | 209681 | 0 | None | - | 0 | Rabbit | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62744 | 209681 | 0 | None | - | 0 | Rabbit | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 14950500 | 106350 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 4.3 | COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL283770 | 106350 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 4.3 | COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 10457997 | 25607 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| CHEMBL128049 | 25607 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| 76308196 | 91769 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 8 | 3 | 6 | 3.9 | CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237877 | 91769 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 8 | 3 | 6 | 3.9 | CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10021888 | 56156 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 7 | 2 | 5 | 4.3 | CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156408 | 56156 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 7 | 2 | 5 | 4.3 | CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10346301 | 175165 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL434615 | 175165 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| 44373238 | 103862 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL267354 | 103862 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| 44300735 | 107537 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL292829 | 107537 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 127035558 | 143125 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734763 | 143125 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127026027 | 144051 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752145 | 144051 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 19792197 | 201713 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL54194 | 201713 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792197 | 201713 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL54194 | 201713 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10457516 | 23559 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(-c4nn[nH]n4)ccc3C(F)(F)F)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12451 | 23559 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(-c4nn[nH]n4)ccc3C(F)(F)F)cc2)n1 | 10.1021/jm00053a013 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 19919870 | 92036 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 13 | 0 | 6 | 7.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259781 | 92036 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 13 | 0 | 6 | 7.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 76315366 | 91724 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 11 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237581 | 91724 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 11 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9986953 | 53367 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 506 | 10 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL153825 | 53367 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 506 | 10 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 76315367 | 91726 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.5 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237583 | 91726 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.5 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341791 | 16744 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 419 | 7 | 2 | 4 | 4.1 | CCCCC1=NC2(CCNCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114771 | 16744 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 419 | 7 | 2 | 4 | 4.1 | CCCCC1=NC2(CCNCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10002423 | 56001 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 5.9 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156279 | 56001 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 5.9 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15699061 | 12080 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL106682 | 12080 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 44274772 | 105413 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL277182 | 105413 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10369902 | 171416 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421629 | 171416 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44274772 | 105413 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL277182 | 105413 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311616 | 108917 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302485 | 108917 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311571 | 211234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72249 | 211234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 11328757 | 212746 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL84573 | 212746 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 15171413 | 113735 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 6 | 1 | 5 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL314982 | 113735 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 6 | 1 | 5 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 15818746 | 130847 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL36324 | 130847 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311567 | 109790 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306922 | 109790 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 14950509 | 90200 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL21968 | 90200 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| 14951064 | 210509 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 10 | 1 | 9 | 2.8 | CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL67764 | 210509 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 10 | 1 | 9 | 2.8 | CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 70684239 | 82992 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058371 | 82992 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 10763626 | 176330 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL443559 | 176330 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 10834137 | 16834 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115273 | 16834 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44277487 | 106048 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281891 | 106048 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 10457566 | 209581 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62269 | 209581 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 14956771 | 213132 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87392 | 213132 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277938 | 107926 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 4.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29540 | 107926 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 4.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9912098 | 115317 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 460 | 9 | 3 | 7 | 4.0 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL320135 | 115317 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 460 | 9 | 3 | 7 | 4.0 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 19385680 | 105657 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL279103 | 105657 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| 76330395 | 92187 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 12 | 0 | 9 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263543 | 92187 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 12 | 0 | 9 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277593 | 106187 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282778 | 106187 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277567 | 108174 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29725 | 108174 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 10482886 | 22286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 558 | 13 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121718 | 22286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 558 | 13 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694738 | 82994 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058373 | 82994 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 17748251 | 100122 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL245444 | 100122 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 14951069 | 210646 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 517 | 14 | 1 | 9 | 4.4 | CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68719 | 210646 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 517 | 14 | 1 | 9 | 4.4 | CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10006693 | 23815 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125454 | 23815 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70686382 | 82991 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058370 | 82991 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44294551 | 191182 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL48459 | 191182 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 76329883 | 91742 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237599 | 91742 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127026338 | 144182 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753277 | 144182 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 10482404 | 54234 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154531 | 54234 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 24828427 | 103607 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265208 | 103607 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 9933179 | 25218 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccc(OC)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL127194 | 25218 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccc(OC)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 127036103 | 143287 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736257 | 143287 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 4286584 | 211725 | 10 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7641 | 211725 | 10 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44296954 | 108737 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 589 | 8 | 1 | 9 | 5.3 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301325 | 108737 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 589 | 8 | 1 | 9 | 5.3 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15662011 | 200138 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52497 | 200138 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10000596 | 27423 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 392 | 5 | 1 | 4 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 | 10.1021/jm00100a007 | |||
| CHEMBL130858 | 27423 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 392 | 5 | 1 | 4 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 | 10.1021/jm00100a007 | |||
| 4286584 | 211725 | 10 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7641 | 211725 | 10 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15662011 | 200138 | 0 | None | - | 0 | Bovine | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52497 | 200138 | 0 | None | - | 0 | Bovine | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14951065 | 210624 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 433 | 9 | 2 | 8 | 2.4 | CCCCc1nn(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68582 | 210624 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 433 | 9 | 2 | 8 | 2.4 | CCCCc1nn(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 19792137 | 92141 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL2261752 | 92141 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792185 | 196225 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51349 | 196225 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792137 | 92141 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL2261752 | 92141 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792185 | 196225 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51349 | 196225 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44275059 | 106851 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 590 | 7 | 2 | 7 | 6.6 | Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287253 | 106851 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 590 | 7 | 2 | 7 | 6.6 | Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44459584 | 103410 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26352 | 103410 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 15698058 | 193902 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49170 | 193902 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 127035545 | 143147 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734955 | 143147 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 70686380 | 82987 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058366 | 82987 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| 44438900 | 154626 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL393305 | 154626 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 15171407 | 212770 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL84792 | 212770 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 127026337 | 144322 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754394 | 144322 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15287882 | 56517 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15670 | 56517 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 127034875 | 143130 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734819 | 143130 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10389251 | 54432 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154708 | 54432 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44293817 | 193156 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 5 | 6.7 | CCCCc1nc2c(C)cccc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48756 | 193156 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 5 | 6.7 | CCCCc1nc2c(C)cccc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 10389251 | 54432 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154708 | 54432 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15654718 | 109046 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303264 | 109046 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 76319034 | 91736 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 572 | 12 | 2 | 8 | 6.4 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237593 | 91736 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 572 | 12 | 2 | 8 | 6.4 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76322691 | 91739 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237596 | 91739 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127034916 | 143178 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 668 | 12 | 2 | 8 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735302 | 143178 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 668 | 12 | 2 | 8 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10052714 | 55962 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 11 | 1 | 7 | 6.9 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156243 | 55962 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 11 | 1 | 7 | 6.9 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10029367 | 57456 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157565 | 57456 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44296945 | 108773 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301569 | 108773 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 71521417 | 93604 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322446 | 93604 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44274747 | 106447 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 621 | 8 | 2 | 9 | 6.2 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284469 | 106447 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 621 | 8 | 2 | 9 | 6.2 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10475572 | 25387 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 10 | 1 | 4 | 5.4 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12766 | 25387 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 10 | 1 | 4 | 5.4 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| 127034917 | 143313 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 654 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736507 | 143313 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 654 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 24828568 | 166384 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 4.8 | CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410325 | 166384 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 4.8 | CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44270367 | 170002 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL418354 | 170002 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44342001 | 16711 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 477 | 9 | 2 | 5 | 3.9 | CCCCC1=NC2(CCN(CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114590 | 16711 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 477 | 9 | 2 | 5 | 3.9 | CCCCC1=NC2(CCN(CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 4286584 | 211725 | 10 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL7641 | 211725 | 10 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 19008901 | 69417 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL178380 | 69417 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| 70688503 | 83104 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 11 | 2 | 8 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058858 | 83104 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 11 | 2 | 8 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10005096 | 25670 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128397 | 25670 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 | 10.1021/jm00100a007 | |||
| 76317815 | 112026 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.6 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115245 | 112026 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.6 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 76311801 | 91735 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 10 | 2 | 8 | 5.7 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237592 | 91735 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 10 | 2 | 8 | 5.7 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19976416 | 212955 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ncccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL86344 | 212955 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ncccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 10032367 | 60762 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 6.1 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL160573 | 60762 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 6.1 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 22850888 | 200793 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52791 | 200793 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 9894404 | 201448 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53174 | 201448 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 132387 | 169113 | 23 | None | 9 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL416477 | 169113 | 23 | None | 9 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 132387 | 169113 | 23 | None | 9 | 3 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL416477 | 169113 | 23 | None | 9 | 3 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 192314 | 121278 | 28 | None | 15 | 3 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237157 | 121278 | 28 | None | 15 | 3 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL333534 | 121278 | 28 | None | 15 | 3 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| 15657904 | 194261 | 4 | None | - | 1 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49410 | 194261 | 4 | None | - | 1 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 10432780 | 171291 | 0 | None | 10 | 3 | Rabbit | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL421473 | 171291 | 0 | None | 10 | 3 | Rabbit | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 15657949 | 23687 | 0 | None | - | 1 | Rabbit | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 428 | 9 | 2 | 6 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL125218 | 23687 | 0 | None | - | 1 | Rabbit | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 428 | 9 | 2 | 6 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL5075338 | 221147 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | None | None | None | CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||||
| CHEMBL266899 | 217486 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9507744 | |||||
| 127030943 | 145973 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787243 | 145973 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787375 | 145973 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 145973 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 44348262 | 23115 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 469 | 6 | 1 | 6 | 4.0 | CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL122891 | 23115 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 469 | 6 | 1 | 6 | 4.0 | CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9912059 | 192135 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48602 | 192135 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 10745817 | 126153 | 0 | None | - | 1 | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111973 | 126153 | 0 | None | - | 1 | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL344464 | 126153 | 0 | None | - | 1 | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL428475 | 220226 | 0 | None | - | 1 | Bovine | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 10094936 | 23608 | 0 | None | 9 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237156 | 23608 | 0 | None | 9 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL124772 | 23608 | 0 | None | 9 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL216830 | 216121 | 30 | None | - | 1 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| 127034873 | 143227 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735744 | 143227 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035715 | 143218 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735652 | 143218 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10408684 | 175951 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.7 | CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL440521 | 175951 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.7 | CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 44348285 | 23204 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL123208 | 23204 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294528 | 108815 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 440 | 8 | 1 | 9 | 3.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL301819 | 108815 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 440 | 8 | 1 | 9 | 3.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294996 | 196572 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL51622 | 196572 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| 10629796 | 103659 | 0 | None | - | 1 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL265681 | 103659 | 0 | None | - | 1 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 9957348 | 193504 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 493 | 9 | 1 | 8 | 5.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48868 | 193504 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 493 | 9 | 1 | 8 | 5.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 11744384 | 39121 | 0 | None | - | 1 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL141065 | 39121 | 0 | None | - | 1 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111972 | 39121 | 0 | None | - | 1 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| 44294791 | 190713 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48145 | 190713 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 9909542 | 184260 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46392 | 184260 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 10365342 | 120272 | 0 | None | 16 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL331983 | 120272 | 0 | None | 16 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 44383615 | 172730 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL425139 | 172730 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294551 | 191182 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48459 | 191182 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9807638 | 193925 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49192 | 193925 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294464 | 194568 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 397 | 6 | 3 | 7 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49587 | 194568 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 397 | 6 | 3 | 7 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 71623945 | 143242 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735839 | 143242 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44295057 | 108111 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL296731 | 108111 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294699 | 194075 | 0 | None | - | 1 | Rabbit | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 5.1 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49294 | 194075 | 0 | None | - | 1 | Rabbit | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 5.1 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL408098 | 219479 | 0 | None | - | 1 | Bovine | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCCCCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC2=CCCC=C2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||||
| CHEMBL268804 | 217543 | 0 | None | -2 | 2 | Bovine | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| CHEMBL406519 | 219391 | 0 | None | - | 1 | Bovine | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 44348369 | 23108 | 0 | None | - | 1 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 495 | 6 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL122855 | 23108 | 0 | None | - | 1 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 495 | 6 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 9912059 | 192135 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48602 | 192135 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294466 | 194688 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 451 | 7 | 3 | 7 | 4.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49663 | 194688 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 451 | 7 | 3 | 7 | 4.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294483 | 108523 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL299741 | 108523 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 15294417 | 190898 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 6 | 2 | 6 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48270 | 190898 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 6 | 2 | 6 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL415025 | 219948 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||||
| CHEMBL384349 | 219102 | 0 | None | -2 | 2 | Bovine | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||||
| CHEMBL402669 | 219308 | 0 | None | - | 1 | Bovine | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| CHEMBL406170 | 219376 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||||
| 127035717 | 143194 | 0 | None | - | 1 | Rabbit | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735409 | 143194 | 0 | None | - | 1 | Rabbit | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10701559 | 162470 | 0 | None | - | 1 | Bovine | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1227 | 42 | 11 | 13 | 4.9 | CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL405031 | 162470 | 0 | None | - | 1 | Bovine | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1227 | 42 | 11 | 13 | 4.9 | CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 44294540 | 108617 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 455 | 8 | 2 | 9 | 3.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL300438 | 108617 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 455 | 8 | 2 | 9 | 3.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 9864307 | 23198 | 0 | None | - | 1 | Rabbit | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 373 | 6 | 3 | 7 | 2.6 | O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00098a018 | |||
| CHEMBL123152 | 23198 | 0 | None | - | 1 | Rabbit | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 373 | 6 | 3 | 7 | 2.6 | O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00098a018 | |||
| 70682146 | 83106 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2058860 | 83106 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127036108 | 143156 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735098 | 143156 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035514 | 143201 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735446 | 143201 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44382928 | 65985 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL170196 | 65985 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9978737 | 125670 | 1 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111971 | 125670 | 1 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL342261 | 125670 | 1 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL415157 | 219953 | 0 | None | 10 | 2 | Bovine | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||||
| 127036107 | 143294 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736319 | 143294 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 127036297 | 143205 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735492 | 143205 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44382968 | 172002 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL422912 | 172002 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44295009 | 193950 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49207 | 193950 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294967 | 195134 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 467 | 9 | 1 | 8 | 4.6 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50109 | 195134 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 467 | 9 | 1 | 8 | 4.6 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 155541125 | 179744 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4517561 | 179744 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| 44295090 | 108431 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL299151 | 108431 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL264230 | 217388 | 0 | None | -3 | 2 | Bovine | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 44294520 | 191067 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48400 | 191067 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294485 | 179347 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL448727 | 179347 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44295010 | 194023 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49262 | 194023 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294515 | 198600 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 501 | 9 | 1 | 9 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL51987 | 198600 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 501 | 9 | 1 | 9 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294676 | 194549 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 451 | 7 | 1 | 7 | 4.7 | CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49573 | 194549 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 451 | 7 | 1 | 7 | 4.7 | CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294616 | 195019 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 5.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49952 | 195019 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 5.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL406888 | 219404 | 0 | None | - | 1 | Bovine | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 44294905 | 195928 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL51084 | 195928 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294465 | 194482 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 411 | 6 | 2 | 8 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49528 | 194482 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 411 | 6 | 2 | 8 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 127035716 | 143212 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735588 | 143212 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 16133225 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 172198 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 2504 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 45266664 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 5272 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| CHEMBL408403 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| DB11842 | 7207 | 52 | None | -14 | 5 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| CHEMBL414918 | 219940 | 0 | None | - | 1 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9507744 | |||||
| 44348285 | 23204 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL123208 | 23204 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44211278 | 193409 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 480 | 9 | 2 | 8 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48799 | 193409 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 480 | 9 | 2 | 8 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44211265 | 184250 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 425 | 8 | 2 | 7 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46391 | 184250 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 425 | 8 | 2 | 7 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 127035515 | 143233 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735769 | 143233 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44339988 | 167786 | 0 | None | -1 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL411624 | 167786 | 0 | None | -1 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 44211267 | 184568 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46433 | 184568 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 127036105 | 143296 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736336 | 143296 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL412717 | 219799 | 0 | None | - | 1 | Bovine | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 127036106 | 143146 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734949 | 143146 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44211263 | 198911 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 2 | 7 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL52036 | 198911 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 2 | 7 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 44295009 | 193950 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49207 | 193950 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294721 | 107997 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 464 | 8 | 1 | 9 | 3.9 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL295935 | 107997 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 464 | 8 | 1 | 9 | 3.9 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 10321186 | 22285 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL121705 | 22285 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 44294518 | 195056 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50007 | 195056 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL216678 | 216116 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||||
| 44294610 | 194924 | 0 | None | - | 1 | Rabbit | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49848 | 194924 | 0 | None | - | 1 | Rabbit | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 73346386 | 99391 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2435818 | 99391 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10048997 | 22273 | 0 | None | 14 | 2 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL121635 | 22273 | 0 | None | 14 | 2 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| 44211264 | 108587 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 8 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL300194 | 108587 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 8 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294618 | 195173 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50174 | 195173 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294637 | 169926 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 451 | 8 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL417910 | 169926 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 451 | 8 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294822 | 107936 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL295498 | 107936 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44211277 | 194745 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49715 | 194745 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294459 | 190887 | 0 | None | - | 1 | Rabbit | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48259 | 190887 | 0 | None | - | 1 | Rabbit | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294539 | 171654 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 8 | 4.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL422050 | 171654 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 8 | 4.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL216061 | 216095 | 15 | None | 1 | 2 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | |||||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/ml500278g | |||||
| 1056 | 10144 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 2405 | 10144 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 77999 | 10144 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| CHEMBL121 | 10144 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| DB00412 | 10144 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 2583 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 592 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 65999 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| DB00966 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 2583 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 592 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 65999 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| DB00966 | 10548 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| CHEMBL411997 | 219747 | 0 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CCSSCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 10390188 | 214036 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 475 | 5 | 1 | 7 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL92950 | 214036 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 475 | 5 | 1 | 7 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL1076604 | 215258 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 16133225 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 172198 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 2504 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 45266664 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 5272 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| CHEMBL408403 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| DB11842 | 7207 | 52 | None | -2 | 5 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| CHEMBL938 | 222686 | 28 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| CHEMBL1076602 | 215256 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076603 | 215257 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 6918 | 7815 | 35 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 9804984 | 7815 | 35 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL189568 | 7815 | 35 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 10479983 | 214109 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 473 | 4 | 1 | 7 | 4.8 | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 | 10.1021/jm00014a024 | |||
| CHEMBL93522 | 214109 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 473 | 4 | 1 | 7 | 4.8 | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 | 10.1021/jm00014a024 | |||
| 183134 | 211623 | 17 | None | - | 1 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL7550 | 211623 | 17 | None | - | 1 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| 9826888 | 214656 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 4.6 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL96552 | 214656 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 4.6 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 | 10.1021/jm00014a024 | |||
| 10004498 | 214058 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 461 | 5 | 1 | 6 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL93159 | 214058 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 461 | 5 | 1 | 6 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL1076663 | 215267 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9015747 | |||||
| 4673492 | 10910 | 9 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| 8324 | 10910 | 9 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL159096 | 10910 | 9 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL1076601 | 215255 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 46880544 | 215264 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076632 | 215264 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| 132387 | 169113 | 23 | None | -9 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL416477 | 169113 | 23 | None | -9 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00070a012 | |||
| 44282952 | 127207 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL35381 | 127207 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2541 | 7573 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 587 | 7573 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 6907 | 7573 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL1016 | 7573 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB00796 | 7573 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB13919 | 7573 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 10344188 | 119425 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 5 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL330298 | 119425 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 5 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 | 10.1021/jm00014a024 | |||
| 10079601 | 219310 | 14 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||||
| CHEMBL404594 | 219310 | 14 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||||
| 10004489 | 213533 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 461 | 4 | 1 | 7 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL90027 | 213533 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 461 | 4 | 1 | 7 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 45102750 | 70552 | 4 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801740 | 70552 | 4 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 11754146 | 166466 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 463 | 5 | 1 | 7 | 5.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL410417 | 166466 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 463 | 5 | 1 | 7 | 5.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL1076613 | 215260 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076633 | 215265 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076662 | 215266 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9015747 | |||||
| CHEMBL1076603 | 215257 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 11994289 | 89252 | 0 | None | -1 | 2 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL217673 | 89252 | 0 | None | -1 | 2 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10031067 | 107128 | 4 | None | 2 | 3 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL289614 | 107128 | 4 | None | 2 | 3 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127030943 | 145973 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787243 | 145973 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787375 | 145973 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 145973 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 132387 | 169113 | 23 | None | -12 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL416477 | 169113 | 23 | None | -12 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 87219032 | 182754 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4588688 | 182754 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 9891811 | 126520 | 1 | None | 8128 | 2 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL347703 | 126520 | 1 | None | 8128 | 2 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524047 | 126520 | 1 | None | 8128 | 2 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 10257882 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| 8448 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL539423 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| DB12548 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| 1481 | 8847 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3749 | 8847 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 589 | 8847 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 6908 | 8847 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1513 | 8847 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| DB01029 | 8847 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1076612 | 215259 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 46880544 | 215264 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076632 | 215264 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 10257882 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| 8448 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| CHEMBL539423 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| DB12548 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| 14956739 | 213081 | 0 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL87074 | 213081 | 0 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 3047757 | 174237 | 23 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.2 | CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL429847 | 174237 | 23 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.2 | CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm9504722 | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL1076633 | 215265 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| 16133225 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 172198 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 2504 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 45266664 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 5272 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| CHEMBL408403 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| DB11842 | 7207 | 52 | None | -2 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 10322229 | 128286 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL358335 | 128286 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10410148 | 211909 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 425 | 6 | 2 | 8 | 3.4 | CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77959 | 211909 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 425 | 6 | 2 | 8 | 3.4 | CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 25141239 | 190645 | 0 | None | - | 1 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 528 | 11 | 2 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480906 | 190645 | 0 | None | - | 1 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 528 | 11 | 2 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10322229 | 128286 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL358335 | 128286 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| 10366402 | 213619 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 448 | 5 | 2 | 8 | 3.8 | CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL90513 | 213619 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 448 | 5 | 2 | 8 | 3.8 | CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 | 10.1021/jm00014a024 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3936 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 8991 | 35 | None | 1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 3936 | 8991 | 35 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 6603900 | 8991 | 35 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL288174 | 8991 | 35 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL5274111 | 200574 | 0 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| 10006413 | 44259 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 506 | 9 | 1 | 7 | 5.7 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145564 | 44259 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 506 | 9 | 1 | 7 | 5.7 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| 14956757 | 74367 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL19018 | 74367 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 45102601 | 176350 | 12 | None | 1995 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4435800 | 176350 | 12 | None | 1995 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 87218373 | 177024 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4445778 | 177024 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218514 | 182865 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4591218 | 182865 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10050044 | 118305 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL327903 | 118305 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL1076604 | 215258 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 145957897 | 168851 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 984 | 28 | 14 | 13 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4160691 | 168851 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 984 | 28 | 14 | 13 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 44320012 | 174702 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL431411 | 174702 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 10603443 | 41586 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 587 | 13 | 3 | 8 | 5.6 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 | 10.1021/jm991050l | |||
| CHEMBL143118 | 41586 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 587 | 13 | 3 | 8 | 5.6 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 | 10.1021/jm991050l | |||
| 9939191 | 105722 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL279629 | 105722 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL97539 | 105722 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10079766 | 103757 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C/CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| CHEMBL266450 | 103757 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C/CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| 10011335 | 168047 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C\CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| CHEMBL412045 | 168047 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C\CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| 192314 | 121278 | 28 | None | -15 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL1237157 | 121278 | 28 | None | -15 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL333534 | 121278 | 28 | None | -15 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| 72168 | 109464 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 554 | 8 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL304639 | 109464 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 554 | 8 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 | 10.1016/j.bmc.2010.10.043 | |||
| 10393016 | 213715 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 5 | 4.9 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL91113 | 213715 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 5 | 4.9 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 9895957 | 17445 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL11706 | 17445 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1016/j.bmc.2012.06.011 | |||
| 9895957 | 17445 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| CHEMBL11706 | 17445 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| 155514738 | 176688 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 656 | 15 | 4 | 8 | 5.3 | CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4440944 | 176688 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 656 | 15 | 4 | 8 | 5.3 | CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 71465043 | 178755 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 565 | 13 | 3 | 7 | 6.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4470834 | 178755 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 565 | 13 | 3 | 7 | 6.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10409294 | 112168 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2cnnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL311657 | 112168 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2cnnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10410197 | 170119 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL419089 | 170119 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 9933044 | 174800 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2nc(S)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL432153 | 174800 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2nc(S)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10411083 | 211819 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 7 | 3 | 9 | 2.7 | CCCc1nc(CO)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77036 | 211819 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 7 | 3 | 9 | 2.7 | CCCc1nc(CO)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 53319274 | 64374 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668000 | 64374 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| 9895957 | 17445 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm058225d | |||
| CHEMBL11706 | 17445 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm058225d | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 44567746 | 198195 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL519274 | 198195 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL5271484 | 200465 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 44567782 | 190503 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 10 | 2 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480341 | 190503 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 10 | 2 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 87218444 | 178227 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463203 | 178227 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 6918 | 7815 | 35 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 9804984 | 7815 | 35 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| CHEMBL189568 | 7815 | 35 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 19029492 | 124852 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340518 | 124852 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 44567709 | 197438 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 9 | 2 | 6 | 3.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL518157 | 197438 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 9 | 2 | 6 | 3.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10027078 | 211983 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 7 | 2 | 8 | 4.5 | CCCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78532 | 211983 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 7 | 2 | 8 | 4.5 | CCCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5272962 | 200520 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 10074277 | 212149 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 489 | 7 | 2 | 9 | 2.5 | CCCc1nc(C)n2nc(S(N)(=O)=O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL79879 | 212149 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 489 | 7 | 2 | 9 | 2.5 | CCCc1nc(C)n2nc(S(N)(=O)=O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10343950 | 211974 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(COC)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78433 | 211974 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(COC)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 11754586 | 113867 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL315881 | 113867 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10001600 | 110883 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL309384 | 110883 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10391688 | 112510 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 512 | 9 | 1 | 10 | 3.2 | CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL312632 | 112510 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 512 | 9 | 1 | 10 | 3.2 | CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 9956392 | 107795 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL294500 | 107795 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| 5311345 | 9795 | 46 | None | -10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 597 | 9795 | 46 | None | -10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL321820 | 9795 | 46 | None | -10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 9978737 | 125670 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111971 | 125670 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL342261 | 125670 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL1076630 | 215262 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 168289415 | 198093 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 9 | 4.8 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5191326 | 198093 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 9 | 4.8 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| 23298215 | 174855 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 7 | 3 | 7 | 5.1 | O=C(O)c1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL432529 | 174855 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 7 | 3 | 7 | 5.1 | O=C(O)c1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| 44567849 | 196001 | 0 | None | - | 1 | Pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL511490 | 196001 | 0 | None | - | 1 | Pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10048997 | 22273 | 0 | None | -14 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL121635 | 22273 | 0 | None | -14 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| 155520317 | 177268 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4449166 | 177268 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155523092 | 177593 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.1 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4453362 | 177593 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.1 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87219128 | 179667 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 14 | 3 | 5 | 6.6 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4515703 | 179667 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 14 | 3 | 5 | 6.6 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218933 | 181861 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 14 | 3 | 5 | 6.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4568554 | 181861 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 14 | 3 | 5 | 6.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10049001 | 212208 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80219 | 212208 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10697700 | 213680 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 539 | 11 | 1 | 5 | 4.8 | CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90872 | 213680 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 539 | 11 | 1 | 5 | 4.8 | CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 | 10.1021/jm9904147 | |||
| 44284308 | 21548 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 617 | 12 | 1 | 10 | 6.4 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206594 | 21548 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 617 | 12 | 1 | 10 | 6.4 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079769 | 21548 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 617 | 12 | 1 | 10 | 6.4 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4299329 | 220393 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL4302429 | 220393 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||||
| 45488134 | 203756 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 1 | 7 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL566614 | 203756 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 1 | 7 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 23298206 | 107530 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2c(C(=O)O)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C3CC3)nc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL292792 | 107530 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2c(C(=O)O)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C3CC3)nc12 | 10.1016/S0960-894X(01)81146-X | |||
| 19029534 | 25335 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127605 | 25335 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10458763 | 211717 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 503 | 8 | 2 | 9 | 2.7 | CCCc1nc(C)n2nc(S(=O)(=O)NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76359 | 211717 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 503 | 8 | 2 | 9 | 2.7 | CCCc1nc(C)n2nc(S(=O)(=O)NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10095683 | 128290 | 0 | None | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL358359 | 128290 | 0 | None | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10095683 | 128290 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL358359 | 128290 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 15480220 | 207513 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 6 | 2 | 6 | 5.6 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccc(F)cc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL60010 | 207513 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 6 | 2 | 6 | 5.6 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccc(F)cc12 | 10.1016/S0960-894X(01)81146-X | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 44254496 | 12397 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 770 | 18 | 7 | 8 | 2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm900651p | |||
| CHEMBL1077582 | 12397 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 770 | 18 | 7 | 8 | 2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm900651p | |||
| 19029594 | 24871 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc([N+](=O)[O-])cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126801 | 24871 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc([N+](=O)[O-])cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 19029638 | 170990 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc([N+](=O)[O-])c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL421092 | 170990 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc([N+](=O)[O-])c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10052744 | 21583 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 530 | 10 | 1 | 5 | 7.2 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1207064 | 21583 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 530 | 10 | 1 | 5 | 7.2 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL343622 | 21583 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 530 | 10 | 1 | 5 | 7.2 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 44567819 | 190694 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481294 | 190694 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10005278 | 211969 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 478 | 6 | 1 | 7 | 4.8 | CCCc1nc(C)n2nc(C(F)(F)F)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78399 | 211969 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 478 | 6 | 1 | 7 | 4.8 | CCCc1nc(C)n2nc(C(F)(F)F)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10049622 | 110919 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL309458 | 110919 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 19029579 | 25276 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.1 | O=C(/N=c1\sc(C2CC2)nn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ccccc1Cl | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127332 | 25276 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.1 | O=C(/N=c1\sc(C2CC2)nn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ccccc1Cl | 10.1016/S0960-894X(97)00026-7 | |||
| 10094936 | 23608 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL1237156 | 23608 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL124772 | 23608 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| 10094936 | 23608 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237156 | 23608 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL124772 | 23608 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 44475015 | 178303 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4464191 | 178303 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155557693 | 181447 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 599 | 13 | 3 | 7 | 6.2 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4558883 | 181447 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 599 | 13 | 3 | 7 | 6.2 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10003793 | 21456 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 9 | 1 | 6 | 4.5 | CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205758 | 21456 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 9 | 1 | 6 | 4.5 | CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145276 | 21456 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 9 | 1 | 6 | 4.5 | CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 10504330 | 213593 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.4 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL90411 | 213593 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.4 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| 155535176 | 178809 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4471668 | 178809 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 46935636 | 109349 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440460 | 109349 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL3040772 | 109349 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL5271135 | 200450 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 10391609 | 21454 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 5.8 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205753 | 21454 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 5.8 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL144952 | 21454 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 5.8 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 45488167 | 203933 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567898 | 203933 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 44567850 | 190742 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481664 | 190742 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 19029509 | 24840 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 5 | 1 | 7 | 4.5 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126643 | 24840 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 5 | 1 | 7 | 4.5 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 123794 | 7680 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| 3944 | 7680 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| 594 | 7680 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| CHEMBL1885579 | 7680 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| 10004228 | 211794 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 456 | 7 | 1 | 8 | 4.5 | CCCc1nc(C)n2nc(SC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76866 | 211794 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 456 | 7 | 1 | 8 | 4.5 | CCCc1nc(C)n2nc(SC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10005644 | 212299 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 7 | 1 | 7 | 5.5 | CCCc1nc(C)n2nc(-c3ccccc3)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80854 | 212299 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 7 | 1 | 7 | 5.5 | CCCc1nc(C)n2nc(-c3ccccc3)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL1076601 | 215255 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 168294859 | 199055 | 0 | None | -19 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5205769 | 199055 | 0 | None | -19 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10029566 | 211856 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 517 | 8 | 1 | 9 | 3.1 | CCCc1nc(C)n2nc(S(=O)(=O)N(C)C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77384 | 211856 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 517 | 8 | 1 | 9 | 3.1 | CCCc1nc(C)n2nc(S(=O)(=O)N(C)C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 59984617 | 92052 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 8 | 2 | 6 | 7.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL2260199 | 92052 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 8 | 2 | 6 | 7.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL1076612 | 215259 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 87218987 | 177786 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.6 | CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4456519 | 177786 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.6 | CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10415026 | 172452 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 544 | 10 | 1 | 5 | 7.5 | CCCCC1=NC(c2ccc(Cl)cc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL424483 | 172452 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 544 | 10 | 1 | 5 | 7.5 | CCCCC1=NC(c2ccc(Cl)cc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 19029491 | 123742 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Cl)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL338670 | 123742 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Cl)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10365342 | 120272 | 0 | None | -16 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL331983 | 120272 | 0 | None | -16 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 155516694 | 176892 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 507 | 12 | 3 | 5 | 5.9 | CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4443691 | 176892 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 507 | 12 | 3 | 5 | 5.9 | CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 19029483 | 25600 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.6 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL128003 | 25600 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.6 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10790260 | 213556 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90187 | 213556 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 135723840 | 145920 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787059 | 145920 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 3936 | 8991 | 35 | None | -1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 6603900 | 8991 | 35 | None | -1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL288174 | 8991 | 35 | None | -1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 44350610 | 124944 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 525 | 8 | 2 | 8 | 4.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340863 | 124944 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 525 | 8 | 2 | 8 | 4.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10005741 | 118227 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL327535 | 118227 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10031067 | 107128 | 4 | None | -2 | 3 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL289614 | 107128 | 4 | None | -2 | 3 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127029976 | 145995 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786145 | 145995 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787767 | 145995 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 23298214 | 108789 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cccnc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL301689 | 108789 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cccnc12 | 10.1016/S0960-894X(01)81146-X | |||
| 19029671 | 124865 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2OC)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340618 | 124865 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2OC)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10745817 | 126153 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111973 | 126153 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL344464 | 126153 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| 87219174 | 176544 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 14 | 3 | 6 | 5.9 | CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4438878 | 176544 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 14 | 3 | 6 | 5.9 | CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44567745 | 190664 | 0 | None | - | 1 | Pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 10 | 2 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481089 | 190664 | 0 | None | - | 1 | Pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 10 | 2 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44350616 | 25599 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 6 | 2 | 8 | 3.6 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127988 | 25599 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 6 | 2 | 8 | 3.6 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10345537 | 118379 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.0 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL328296 | 118379 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.0 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10481196 | 119523 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 7 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL330508 | 119523 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 7 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 | 10.1021/jm00014a024 | |||
| 10432780 | 171291 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL421473 | 171291 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| 10432780 | 171291 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL421473 | 171291 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 127029977 | 145996 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786986 | 145996 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787768 | 145996 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 44325313 | 214219 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.3 | CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| CHEMBL94106 | 214219 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.3 | CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| 127866 | 109582 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL305365 | 109582 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81146-X | |||
| 127866 | 109582 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81147-1 | |||
| CHEMBL305365 | 109582 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81147-1 | |||
| 132404 | 126564 | 14 | None | 36 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL348126 | 126564 | 14 | None | 36 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| 15658054 | 213505 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 8 | 2 | 8 | 3.7 | CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL89877 | 213505 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 8 | 2 | 8 | 3.7 | CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL5273768 | 200555 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271903 | 200481 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| 19029687 | 26145 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL129181 | 26145 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 11744384 | 39121 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL141065 | 39121 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111972 | 39121 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| 45488164 | 204610 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 602 | 12 | 1 | 7 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 | 10.1021/jm901272d | |||
| CHEMBL572276 | 204610 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 602 | 12 | 1 | 7 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 | 10.1021/jm901272d | |||
| 118719137 | 122223 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1405 | 38 | 7 | 16 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm401789v | |||
| CHEMBL3234445 | 122223 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1405 | 38 | 7 | 16 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm401789v | |||
| CHEMBL3350781 | 122223 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1405 | 38 | 7 | 16 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm401789v | |||
| 10252692 | 211963 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.8 | CCCc1nc(CC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78342 | 211963 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.8 | CCCc1nc(CC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10050933 | 212279 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 4.0 | CCCc1nc(C)n2nc(C(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80688 | 212279 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 4.0 | CCCc1nc(C)n2nc(C(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5282200 | 200928 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 132840 | 112266 | 22 | None | 1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL312104 | 112266 | 22 | None | 1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 132840 | 112266 | 22 | None | -1 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL312104 | 112266 | 22 | None | -1 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5277518 | 200715 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL1076602 | 215256 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 145957579 | 169090 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 497 | 7 | 0 | 3 | 7.0 | CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4164514 | 169090 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 497 | 7 | 0 | 3 | 7.0 | CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| 5249743 | 113802 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL315444 | 113802 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9904147 | |||
| 10674630 | 213611 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 10 | 1 | 5 | 5.3 | CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90483 | 213611 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 10 | 1 | 5 | 5.3 | CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 11577472 | 21384 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 5.2 | CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204970 | 21384 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 5.2 | CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2021416 | 21384 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 5.2 | CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 5249743 | 113802 | 1 | None | -1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL315444 | 113802 | 1 | None | -1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 53317942 | 64372 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1667999 | 64372 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 5249743 | 113802 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL315444 | 113802 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 87218826 | 178876 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 13 | 3 | 5 | 7.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4472489 | 178876 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 13 | 3 | 5 | 7.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 45488163 | 204546 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 630 | 13 | 0 | 8 | 7.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 | 10.1021/jm901272d | |||
| CHEMBL571763 | 204546 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 630 | 13 | 0 | 8 | 7.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 | 10.1021/jm901272d | |||
| 163409136 | 197681 | 3 | None | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5185088 | 197681 | 3 | None | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5289070 | 201235 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL1076613 | 215260 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 10433378 | 211696 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76149 | 211696 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10071944 | 211796 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 1 | 8 | 3.8 | CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76900 | 211796 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 1 | 8 | 3.8 | CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5275739 | 200649 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 19029650 | 27012 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(OC)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL130530 | 27012 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(OC)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 168295859 | 199064 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5205969 | 199064 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5287876 | 201178 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| 45488125 | 203932 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 360 | 7 | 1 | 5 | 3.6 | CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567897 | 203932 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 360 | 7 | 1 | 5 | 3.6 | CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 10742620 | 64376 | 0 | None | 16 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668003 | 64376 | 0 | None | 16 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 131590 | 27475 | 44 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL130896 | 27475 | 44 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 131590 | 27475 | 44 | None | -1 | 3 | Rabbit | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL130896 | 27475 | 44 | None | -1 | 3 | Rabbit | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00052a006 | |||
| 44567851 | 190584 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480506 | 190584 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 19029656 | 125245 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Br)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL341292 | 125245 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Br)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2806 | 10741 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 3937 | 10741 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 593 | 10741 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 60846 | 10741 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| DB00177 | 10741 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 25141238 | 199324 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 11 | 1 | 6 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL521093 | 199324 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 11 | 1 | 6 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127031545 | 145974 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787379 | 145974 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787701 | 145974 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 192314 | 121278 | 28 | None | -26 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237157 | 121278 | 28 | None | -26 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL333534 | 121278 | 28 | None | -26 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| 136093942 | 145872 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3786570 | 145872 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44567817 | 189818 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 9 | 1 | 6 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL479399 | 189818 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 9 | 1 | 6 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 23298216 | 169958 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 5 | 2 | 6 | 4.9 | Cc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL418122 | 169958 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 5 | 2 | 6 | 4.9 | Cc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| 19029654 | 25115 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2[N+](=O)[O-])s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127090 | 25115 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2[N+](=O)[O-])s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10141821 | 106834 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL287116 | 106834 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 9804423 | 209503 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 451 | 7 | 2 | 6 | 5.5 | CCCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL61814 | 209503 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 451 | 7 | 2 | 6 | 5.5 | CCCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| 19029618 | 124633 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Br)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340304 | 124633 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Br)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| CHEMBL1076631 | 215263 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 44350472 | 25081 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 593 | 6 | 1 | 7 | 4.7 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2I)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127068 | 25081 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 593 | 6 | 1 | 7 | 4.7 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2I)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10096683 | 213868 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.4 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL91928 | 213868 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.4 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| 3936 | 8991 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 6603900 | 8991 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL288174 | 8991 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 3936 | 8991 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 8991 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 8991 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 44284325 | 21546 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 603 | 12 | 1 | 10 | 6.1 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206585 | 21546 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 603 | 12 | 1 | 10 | 6.1 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079768 | 21546 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 603 | 12 | 1 | 10 | 6.1 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10348632 | 212207 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.9 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80218 | 212207 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.9 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 11672486 | 105287 | 0 | None | -3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL276163 | 105287 | 0 | None | -3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL5283862 | 201010 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5276125 | 200663 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 44567781 | 190501 | 0 | None | - | 1 | Pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 11 | 1 | 6 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480340 | 190501 | 0 | None | - | 1 | Pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 11 | 1 | 6 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL1076664 | 215268 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 155526996 | 177919 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 14 | 3 | 5 | 6.8 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4458466 | 177919 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 14 | 3 | 5 | 6.8 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218835 | 177963 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 539 | 13 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4459070 | 177963 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 539 | 13 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155552503 | 180949 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 13 | 3 | 5 | 6.5 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4547120 | 180949 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 13 | 3 | 5 | 6.5 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10764613 | 213686 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 4.5 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90887 | 213686 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 4.5 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 145952582 | 169756 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 782 | 12 | 0 | 6 | 10.6 | CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4175147 | 169756 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 782 | 12 | 0 | 6 | 10.6 | CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| 19029482 | 123829 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Br)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL339120 | 123829 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Br)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10507383 | 112882 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 5.6 | CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL313392 | 112882 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 5.6 | CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 11801362 | 113864 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 580 | 9 | 2 | 5 | 5.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL315873 | 113864 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 580 | 9 | 2 | 5 | 5.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | 10.1021/jm9904147 | |||
| 10025379 | 212068 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 4.1 | CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL79171 | 212068 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 4.1 | CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10324104 | 212314 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 511 | 10 | 2 | 10 | 3.8 | CCCc1nc(C)n2nc(NCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80967 | 212314 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 511 | 10 | 2 | 10 | 3.8 | CCCc1nc(C)n2nc(NCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 9914750 | 210031 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 6 | 2 | 6 | 6.1 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cc(Cl)ccc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL64567 | 210031 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 6 | 2 | 6 | 6.1 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cc(Cl)ccc12 | 10.1016/S0960-894X(01)81146-X | |||
| 19029652 | 124874 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Cl)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340662 | 124874 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Cl)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 23298208 | 209943 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 7 | 2 | 7 | 5.5 | COc1ccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c2c1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL64220 | 209943 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 7 | 2 | 7 | 5.5 | COc1ccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c2c1 | 10.1016/S0960-894X(01)81146-X | |||
| 10765881 | 213685 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90885 | 213685 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 44567818 | 190665 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 4.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481106 | 190665 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 4.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10321731 | 170226 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(C(=O)O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL419835 | 170226 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(C(=O)O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10251107 | 211785 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 5 | 2 | 8 | 3.1 | CCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76787 | 211785 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 5 | 2 | 8 | 3.1 | CCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 44350526 | 24979 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127002 | 24979 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 19029576 | 106749 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL286537 | 106749 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 44567744 | 190663 | 0 | None | - | 1 | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481088 | 190663 | 0 | None | - | 1 | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 18950393 | 174956 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1ncc(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL433230 | 174956 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1ncc(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 44312565 | 211550 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| CHEMBL74767 | 211550 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| 9872676 | 84970 | 0 | None | -9332 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| CHEMBL210514 | 84970 | 0 | None | -9332 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| 10790818 | 213700 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 5 | 4.7 | Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90999 | 213700 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 5 | 4.7 | Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1021/jm9904147 | |||
| 44283775 | 21551 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 591 | 9 | 1 | 8 | 6.8 | CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206631 | 21551 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 591 | 9 | 1 | 8 | 6.8 | CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079770 | 21551 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 591 | 9 | 1 | 8 | 6.8 | CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 87218678 | 177114 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4447138 | 177114 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 75031588 | 180487 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535903 | 180487 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 168274602 | 197155 | 0 | None | -97 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5177359 | 197155 | 0 | None | -97 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10695405 | 213299 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL88471 | 213299 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 155522135 | 177434 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 651 | 14 | 3 | 5 | 8.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4451425 | 177434 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 651 | 14 | 3 | 5 | 8.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218371 | 180450 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4534876 | 180450 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10095241 | 118247 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 4.7 | Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL327633 | 118247 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 4.7 | Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| 10028164 | 119353 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 481 | 6 | 1 | 8 | 4.3 | CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| CHEMBL330109 | 119353 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 481 | 6 | 1 | 8 | 4.3 | CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| 135723852 | 145918 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787050 | 145918 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44284107 | 21383 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 561 | 10 | 1 | 10 | 5.1 | CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204966 | 21383 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 561 | 10 | 1 | 10 | 5.1 | CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079784 | 21383 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 561 | 10 | 1 | 10 | 5.1 | CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 23298211 | 169989 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ncccc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL418306 | 169989 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ncccc12 | 10.1016/S0960-894X(01)81146-X | |||
| 11813485 | 24861 | 0 | None | 8 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 534 | 9 | 1 | 6 | 6.0 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm020138n | |||
| CHEMBL126755 | 24861 | 0 | None | 8 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 534 | 9 | 1 | 6 | 6.0 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm020138n | |||
| 10697829 | 213917 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 1 | 5 | 4.5 | CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL92225 | 213917 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 1 | 5 | 4.5 | CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 168290795 | 198726 | 0 | None | -33 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5200734 | 198726 | 0 | None | -33 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10790819 | 118239 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 4.4 | O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL327594 | 118239 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 4.4 | O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| 44567852 | 190585 | 0 | None | - | 1 | Pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 9 | 1 | 5 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480507 | 190585 | 0 | None | - | 1 | Pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 9 | 1 | 5 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 123814 | 7209 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701490g | |||||
| 5368 | 7209 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701490g | |||||
| CHEMBL261120 | 7209 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701490g | |||||
| 123814 | 7209 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm900651p | |||||
| 5368 | 7209 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm900651p | |||||
| CHEMBL261120 | 7209 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm900651p | |||||
| 10480349 | 212197 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 481 | 7 | 3 | 8 | 3.2 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80167 | 212197 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 481 | 7 | 3 | 8 | 3.2 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1 | 10.1021/jm00041a016 | |||
| 10050326 | 125981 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 9 | 1 | 5 | 5.9 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL343251 | 125981 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 9 | 1 | 5 | 5.9 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 168279676 | 197908 | 0 | None | -11 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5188126 | 197908 | 0 | None | -11 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10744859 | 213370 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 4.4 | CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL88924 | 213370 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 4.4 | CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 44350541 | 125223 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C(F)(F)F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL341109 | 125223 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C(F)(F)F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10053872 | 170256 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 6 | 2 | 8 | 3.2 | CCCc1ncn2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL420028 | 170256 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 6 | 2 | 8 | 3.2 | CCCc1ncn2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 168287840 | 198085 | 0 | None | -32 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5191241 | 198085 | 0 | None | -32 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 19029545 | 24787 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126351 | 24787 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2806 | 10741 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 3937 | 10741 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 593 | 10741 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 60846 | 10741 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| DB00177 | 10741 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 44350499 | 201717 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(OC)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL541992 | 201717 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(OC)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10388491 | 211895 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 439 | 7 | 2 | 8 | 3.9 | CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77783 | 211895 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 439 | 7 | 2 | 8 | 3.9 | CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10388529 | 212287 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80773 | 212287 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 1610 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 3941 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 3961 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 590 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL191 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| DB00678 | 9126 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 87218492 | 177684 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 14 | 3 | 5 | 6.4 | CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4454778 | 177684 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 14 | 3 | 5 | 6.4 | CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218698 | 179068 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4474870 | 179068 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| 25190005 | 180816 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 12 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4543532 | 180816 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 12 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 9846347 | 205416 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 437 | 6 | 2 | 6 | 5.1 | CCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL57907 | 205416 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 437 | 6 | 2 | 6 | 5.1 | CCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| 44350543 | 103467 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(F)(F)F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL264003 | 103467 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(F)(F)F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10340697 | 111523 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 396 | 6 | 1 | 7 | 3.5 | CCCc1ncn2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL310678 | 111523 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 396 | 6 | 1 | 7 | 3.5 | CCCc1ncn2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 155529942 | 178255 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 569 | 15 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463575 | 178255 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 569 | 15 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155547799 | 180467 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535256 | 180467 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218352 | 181201 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 567 | 13 | 3 | 5 | 7.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4552884 | 181201 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 567 | 13 | 3 | 5 | 7.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 45488150 | 203799 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.4 | CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567054 | 203799 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.4 | CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 25141240 | 190372 | 0 | None | - | 1 | Pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480122 | 190372 | 0 | None | - | 1 | Pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10410991 | 211730 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.1 | CCCc1nc(C)n2c(=O)n(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76421 | 211730 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.1 | CCCc1nc(C)n2c(=O)n(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 24828743 | 102943 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 788 | 20 | 8 | 9 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| CHEMBL260622 | 102943 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 788 | 20 | 8 | 9 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| 19029649 | 24715 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C(F)(F)F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL125964 | 24715 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C(F)(F)F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10457973 | 21455 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 6.2 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205756 | 21455 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 6.2 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145036 | 21455 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 6.2 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1076629 | 215261 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 9895957 | 17445 | 18 | None | -3 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| CHEMBL11706 | 17445 | 18 | None | -3 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| 9982165 | 212242 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 470 | 8 | 2 | 9 | 2.6 | CCCc1nc(C)n2c(=O)n(CCO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80446 | 212242 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 470 | 8 | 2 | 9 | 2.6 | CCCc1nc(C)n2c(=O)n(CCO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 18950387 | 21340 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204443 | 21340 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1790055 | 21340 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 44283773 | 21386 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 588 | 12 | 1 | 9 | 5.1 | CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204974 | 21386 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 588 | 12 | 1 | 9 | 5.1 | CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2021415 | 21386 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 588 | 12 | 1 | 9 | 5.1 | CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 87218658 | 177789 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 14 | 3 | 5 | 6.7 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4456544 | 177789 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 14 | 3 | 5 | 6.7 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87219028 | 178380 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 12 | 3 | 6 | 5.2 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4465325 | 178380 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 12 | 3 | 6 | 5.2 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44567816 | 197124 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL517685 | 197124 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44567780 | 198963 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 10 | 2 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL520421 | 198963 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 10 | 2 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 9910978 | 21381 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 6 | 5.2 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204954 | 21381 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 6 | 5.2 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL36259 | 21381 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 6 | 5.2 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 | 10.1016/S0960-894X(01)81137-9 | |||
| 168275495 | 197250 | 0 | None | -66 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5178838 | 197250 | 0 | None | -66 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10251334 | 211781 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 7 | 2 | 6 | 4.4 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76775 | 211781 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 7 | 2 | 6 | 4.4 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00041a016 | |||
| 155533580 | 178655 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4469350 | 178655 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218397 | 177932 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4458683 | 177932 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10077050 | 92051 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 586 | 8 | 0 | 8 | 7.1 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL2260198 | 92051 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 586 | 8 | 0 | 8 | 7.1 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 | 10.1007/s00044-008-9153-9 | |||
| 10100370 | 109951 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 4.2 | CCCc1nc(CCC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL308138 | 109951 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 4.2 | CCCc1nc(CCC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 15657894 | 213872 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| CHEMBL1202852 | 213872 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| CHEMBL91953 | 213872 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| 9805192 | 97730 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL239393 | 97730 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 19029619 | 25278 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127343 | 25278 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 44284094 | 21385 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 11 | 1 | 8 | 6.0 | CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204972 | 21385 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 11 | 1 | 8 | 6.0 | CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079782 | 21385 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 11 | 1 | 8 | 6.0 | CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 155512629 | 176432 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 563 | 15 | 3 | 5 | 7.0 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4437331 | 176432 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 563 | 15 | 3 | 5 | 7.0 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 168270996 | 196838 | 0 | None | -64 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5172324 | 196838 | 0 | None | -64 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168287782 | 198603 | 0 | None | -22 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5198739 | 198603 | 0 | None | -22 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 18950379 | 21350 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204547 | 21350 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL287065 | 21350 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 | 10.1016/S0960-894X(01)81137-9 | |||
| 18950381 | 21351 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204548 | 21351 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL288691 | 21351 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O | 10.1016/S0960-894X(01)81137-9 | |||
| 9806325 | 21380 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 8 | 2 | 7 | 5.1 | CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204952 | 21380 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 8 | 2 | 7 | 5.1 | CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524049 | 21380 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 8 | 2 | 7 | 5.1 | CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 155513439 | 176509 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 13 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4438435 | 176509 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 13 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155565351 | 182356 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 13 | 3 | 5 | 6.7 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4579452 | 182356 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 13 | 3 | 5 | 6.7 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 19029624 | 24812 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126490 | 24812 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10252591 | 211915 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 4.4 | CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78021 | 211915 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 4.4 | CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 9935424 | 21453 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 5.3 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205739 | 21453 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 5.3 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL141659 | 21453 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 5.3 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm00103a014 | |||
| 163409135 | 196962 | 3 | None | 37 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5174180 | 196962 | 3 | None | 37 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| 10254899 | 213674 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 4.2 | CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| CHEMBL90834 | 213674 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 4.2 | CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| 11488492 | 100276 | 0 | None | - | 1 | Pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL246255 | 100276 | 0 | None | - | 1 | Pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44284306 | 21547 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 631 | 11 | 1 | 10 | 6.8 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206588 | 21547 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 631 | 11 | 1 | 10 | 6.8 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079781 | 21547 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 631 | 11 | 1 | 10 | 6.8 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10884983 | 45082 | 0 | None | -1 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL146275 | 45082 | 0 | None | -1 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10884983 | 45082 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL146275 | 45082 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 10093827 | 211686 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 424 | 5 | 2 | 8 | 3.5 | Cc1nc(C2CC2)c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(O)nn12 | 10.1021/jm00041a016 | |||
| CHEMBL76079 | 211686 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 424 | 5 | 2 | 8 | 3.5 | Cc1nc(C2CC2)c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(O)nn12 | 10.1021/jm00041a016 | |||
| 9980359 | 21581 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.2 | CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1207054 | 21581 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.2 | CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL342287 | 21581 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.2 | CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 18950396 | 21341 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 631 | 8 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204444 | 21341 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 631 | 8 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524048 | 21341 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 631 | 8 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10459016 | 43591 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 510 | 10 | 1 | 5 | 6.8 | CCCCC1=NC(c2ccccc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145017 | 43591 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 510 | 10 | 1 | 5 | 6.8 | CCCCC1=NC(c2ccccc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 10368569 | 212233 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 3.9 | CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80380 | 212233 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 3.9 | CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 127034038 | 145975 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3785563 | 145975 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787702 | 145975 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10480064 | 118549 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 4.5 | CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| CHEMBL328738 | 118549 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 4.5 | CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| 10027183 | 171031 | 0 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 7 | 2 | 9 | 3.9 | CCCc1nc(SC)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL421141 | 171031 | 0 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 7 | 2 | 9 | 3.9 | CCCc1nc(SC)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 168270075 | 196832 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 541 | 8 | 1 | 9 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5172242 | 196832 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 541 | 8 | 1 | 9 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 44567884 | 189788 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 11 | 1 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL479367 | 189788 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 11 | 1 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10348903 | 112188 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 8 | 2 | 9 | 3.4 | CCCc1nc(COC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL311825 | 112188 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 8 | 2 | 9 | 3.4 | CCCc1nc(COC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 145946191 | 174311 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| CHEMBL3234454 | 174311 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| CHEMBL4300168 | 174311 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| 10369660 | 212195 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 528 | 10 | 1 | 10 | 4.5 | CCCc1nc(C)n2nc(SCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80161 | 212195 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 528 | 10 | 1 | 10 | 4.5 | CCCc1nc(C)n2nc(SCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10456328 | 41542 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 448 | 9 | 1 | 5 | 5.7 | CCCCC1=NC(C)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL143083 | 41542 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 448 | 9 | 1 | 5 | 5.7 | CCCCC1=NC(C)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 4823 | 100337 | 91 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| CHEMBL24646 | 100337 | 91 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| 1610 | 9126 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 9126 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 9126 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 9126 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 9126 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1610 | 9126 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 9126 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 9126 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 9126 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 9126 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 9126 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 2806 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 593 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 2583 | 10548 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 10548 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 10548 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 10548 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 36736 | 10247 | 0 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 598 | 10247 | 0 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 6324663 | 10247 | 0 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL356431 | 10247 | 0 | None | - | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 1037 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 3940 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 588 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| DB00876 | 8359 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 2806 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 593 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 10741 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 1037 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 3940 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 588 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| DB00876 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 2540 | 11173 | 111 | None | - | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| CHEMBL1014 | 11173 | 111 | None | - | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 2583 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 16133225 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 172198 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 2504 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 45266664 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 5272 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| DB11842 | 7207 | 52 | None | -1 | 5 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 16133225 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 172198 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 2504 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 45266664 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 5272 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| DB11842 | 7207 | 52 | None | -14 | 5 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 1610 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 2541 | 7573 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 587 | 7573 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 6907 | 7573 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| CHEMBL1016 | 7573 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| DB00796 | 7573 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| DB13919 | 7573 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 6916 | 10256 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6914 | 10257 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 12949261 | |||||
| 6903 | 10253 | 0 | None | - | 1 | Rat | 7.1 | pKd | = | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 10066768 | |||||
| 6903 | 10253 | 0 | None | - | 1 | Rat | 7.1 | pKd | = | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 3082475 | 10649 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| 6902 | 10649 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| CHEMBL4297447 | 10649 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| DB12199 | 10649 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 6915 | 10252 | 0 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 1037 | 8359 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 3940 | 8359 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 5281037 | 8359 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 588 | 8359 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| CHEMBL813 | 8359 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| DB00876 | 8359 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 6904 | 10254 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 10066768 | |||||
| 6904 | 10254 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6905 | 10258 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| None | 222943 | 0 | 125I-Angiotensin II | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 395 | 4 | 1 | 6 | 4.4 | CCC1=NC2=C(N1C3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N=C(C=C2C)C | None | |||
| 16133225 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 172198 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 2504 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 45266664 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 5272 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| CHEMBL408403 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| DB11842 | 7207 | 52 | 125I-Angiotensin II | -1 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 36736 | 10247 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 598 | 10247 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 6324663 | 10247 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| CHEMBL356431 | 10247 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 179 | 7188 | 115 | 3H-angiotensin II | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2159 | 7188 | 115 | 3H-angiotensin II | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 963 | 7188 | 115 | 3H-angiotensin II | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| CHEMBL243712 | 7188 | 115 | 3H-angiotensin II | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| DB06288 | 7188 | 115 | 3H-angiotensin II | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 135398737 | 7745 | 93 | 3H-angiotensin II | -4168 | 90 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 7745 | 93 | 3H-angiotensin II | -4168 | 90 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 7745 | 93 | 3H-angiotensin II | -4168 | 90 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 7745 | 93 | 3H-angiotensin II | -4168 | 90 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 7745 | 93 | 3H-angiotensin II | -4168 | 90 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 1353 | 8692 | 93 | 3H-angiotensin II | -6918 | 85 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 8692 | 93 | 3H-angiotensin II | -6918 | 85 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 8692 | 93 | 3H-angiotensin II | -6918 | 85 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 8692 | 93 | 3H-angiotensin II | -6918 | 85 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 8692 | 93 | 3H-angiotensin II | -6918 | 85 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 1973 | 210262 | 15 | 125I-[SAR1, ILe8]-AII | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| CHEMBL1394464 | 210262 | 15 | 125I-[SAR1, ILe8]-AII | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| CHEMBL66089 | 210262 | 15 | 125I-[SAR1, ILe8]-AII | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| 1610 | 9126 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 9126 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 9126 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 9126 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 9126 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 9126 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| None | 222942 | 0 | 125I-Angiotensin II | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 424 | 10 | 2 | 5 | 4.7 | CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O | None | |||
| 2806 | 10741 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 10741 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 593 | 10741 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 10741 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 10741 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 10741 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1610 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 9126 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1481 | 8847 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 3749 | 8847 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 589 | 8847 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 6908 | 8847 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| CHEMBL1513 | 8847 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| DB01029 | 8847 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 1481 | 8847 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 3749 | 8847 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 589 | 8847 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 6908 | 8847 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| CHEMBL1513 | 8847 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| DB01029 | 8847 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 2540 | 11173 | 111 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| CHEMBL1014 | 11173 | 111 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 16133225 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 172198 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 2504 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 45266664 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 5272 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| DB11842 | 7207 | 52 | None | -2 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 1056 | 10144 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 2405 | 10144 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 77999 | 10144 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| CHEMBL121 | 10144 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| DB00412 | 10144 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 2583 | 10548 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 10548 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 10548 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 10548 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 10548 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 36736 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 598 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 6324663 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL356431 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 11944 | 10648 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 155552190 | 10648 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| CHEMBL4544228 | 10648 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 11943 | 10647 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 145925549 | 10647 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| CHEMBL4438122 | 10647 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 11930 | 7806 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 15780052 | 7806 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| CHEMBL289472 | 7806 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 11931 | 7851 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 126456406 | 7851 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 6894 | 7206 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 21464395 | |||||
| 91691124 | 7206 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 21464395 | |||||
| 136218976 | 6938 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | |||
| 6913 | 6938 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | |||
| 60921 | 10242 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| 6899 | 10242 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| CHEMBL305544 | 10242 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| DB01347 | 10242 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| 10257882 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| 8448 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| CHEMBL539423 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| DB12548 | 10418 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||