Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 44300265 | 204445 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 517 | 9 | 5 | 3 | 3.7 | O=C(Cc1ccc(Cl)cc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL57104 | 204445 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 517 | 9 | 5 | 3 | 3.7 | O=C(Cc1ccc(Cl)cc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44300355 | 203318 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 484 | 9 | 5 | 4 | 2.4 | O=C(Cc1cccnc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL56369 | 203318 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 484 | 9 | 5 | 4 | 2.4 | O=C(Cc1cccnc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44300451 | 204866 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 443 | 9 | 4 | 4 | 3.4 | O=C(N/N=C/c1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL57438 | 204866 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 443 | 9 | 4 | 4 | 3.4 | O=C(N/N=C/c1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46881642 | 14868 | 0 | None | 12 | 2 | Mouse | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.1 | CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1091468 | 14868 | 0 | None | 12 | 2 | Mouse | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.1 | CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884660 | 13214 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1082471 | 13214 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884661 | 14590 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089512 | 14590 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884627 | 15149 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093170 | 15149 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 54580462 | 67605 | 0 | None | 4 | 2 | Mouse | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 422 | 6 | 3 | 5 | 3.9 | CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762251 | 67605 | 0 | None | 4 | 2 | Mouse | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 422 | 6 | 3 | 5 | 3.9 | CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54581475 | 67627 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762275 | 67627 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54581475 | 67627 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762275 | 67627 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 4900723 | 15352 | 1 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 377 | 3 | 2 | 6 | 1.9 | CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094727 | 15352 | 1 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 377 | 3 | 2 | 6 | 1.9 | CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887826 | 15353 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 322 | 3 | 2 | 5 | 2.2 | CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094728 | 15353 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 322 | 3 | 2 | 5 | 2.2 | CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887767 | 15357 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 390 | 3 | 2 | 5 | 3.9 | Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094771 | 15357 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 390 | 3 | 2 | 5 | 3.9 | Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887768 | 15358 | 0 | None | -11 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.3 | CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094772 | 15358 | 0 | None | -11 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.3 | CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887765 | 15429 | 0 | None | -10 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 348 | 3 | 2 | 5 | 2.7 | Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095424 | 15429 | 0 | None | -10 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 348 | 3 | 2 | 5 | 2.7 | Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46888066 | 15444 | 0 | None | -21 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 390 | 5 | 2 | 5 | 3.9 | CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095528 | 15444 | 0 | None | -21 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 390 | 5 | 2 | 5 | 3.9 | CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46888068 | 15447 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 3 | 1 | 6 | 3.1 | Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095530 | 15447 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 3 | 1 | 6 | 3.1 | Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887766 | 15467 | 0 | None | -6 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095741 | 15467 | 0 | None | -6 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887915 | 15558 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 392 | 4 | 2 | 6 | 3.1 | COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096531 | 15558 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 392 | 4 | 2 | 6 | 3.1 | COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887916 | 15559 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 430 | 3 | 2 | 5 | 4.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096532 | 15559 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 430 | 3 | 2 | 5 | 4.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887946 | 15563 | 0 | None | -25 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 406 | 3 | 2 | 7 | 2.8 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096546 | 15563 | 0 | None | -25 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 406 | 3 | 2 | 7 | 2.8 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887947 | 15564 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 368 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096547 | 15564 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 368 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887948 | 15565 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 328 | 3 | 2 | 5 | 2.5 | CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096548 | 15565 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 328 | 3 | 2 | 5 | 2.5 | CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887949 | 15592 | 0 | None | -9 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 342 | 2 | 2 | 5 | 2.9 | CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096819 | 15592 | 0 | None | -9 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 342 | 2 | 2 | 5 | 2.9 | CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46888069 | 15655 | 0 | None | -13 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 404 | 3 | 1 | 7 | 3.2 | CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1097471 | 15655 | 0 | None | -13 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 404 | 3 | 1 | 7 | 3.2 | CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887875 | 15675 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 336 | 4 | 3 | 5 | 2.9 | CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1097551 | 15675 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 336 | 4 | 3 | 5 | 2.9 | CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887824 | 15725 | 0 | None | -20 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.0 | Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098097 | 15725 | 0 | None | -20 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.0 | Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 3288900 | 15726 | 8 | None | -2 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 364 | 3 | 2 | 6 | 1.9 | Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098098 | 15726 | 8 | None | -2 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 364 | 3 | 2 | 6 | 1.9 | Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 25249151 | 15742 | 4 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098185 | 15742 | 4 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 4899895 | 15743 | 1 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 370 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098186 | 15743 | 1 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 370 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887825 | 15772 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 363 | 3 | 3 | 6 | 1.5 | Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098433 | 15772 | 0 | None | 1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 363 | 3 | 3 | 6 | 1.5 | Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887950 | 15801 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 4 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098535 | 15801 | 0 | None | -1 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 4 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887914 | 21002 | 0 | None | -2 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.2 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1199153 | 21002 | 0 | None | -2 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.2 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 4900723 | 15352 | 1 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 377 | 3 | 2 | 6 | 1.9 | CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094727 | 15352 | 1 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 377 | 3 | 2 | 6 | 1.9 | CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887767 | 15357 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 390 | 3 | 2 | 5 | 3.9 | Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094771 | 15357 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 390 | 3 | 2 | 5 | 3.9 | Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887915 | 15558 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 392 | 4 | 2 | 6 | 3.1 | COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096531 | 15558 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 392 | 4 | 2 | 6 | 3.1 | COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887916 | 15559 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 430 | 3 | 2 | 5 | 4.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096532 | 15559 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 430 | 3 | 2 | 5 | 4.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887947 | 15564 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 368 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096547 | 15564 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 368 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887948 | 15565 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 328 | 3 | 2 | 5 | 2.5 | CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096548 | 15565 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 328 | 3 | 2 | 5 | 2.5 | CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| 25249151 | 15742 | 4 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098185 | 15742 | 4 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 376 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 4899895 | 15743 | 1 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 370 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098186 | 15743 | 1 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 370 | 4 | 3 | 5 | 3.8 | Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887825 | 15772 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 363 | 3 | 3 | 6 | 1.5 | Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098433 | 15772 | 0 | None | -1 | 2 | Rat | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 363 | 3 | 3 | 6 | 1.5 | Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46882060 | 13085 | 0 | None | -2 | 2 | Mouse | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 5.3 | CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081866 | 13085 | 0 | None | -2 | 2 | Mouse | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 5.3 | CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881560 | 13764 | 0 | None | -13 | 2 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084697 | 13764 | 0 | None | -13 | 2 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46845425 | 7819 | 2 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 8504 | 7819 | 2 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089721 | 7819 | 2 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 25026056 | 14953 | 0 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091985 | 14953 | 0 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884630 | 15192 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093459 | 15192 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707362 | 88647 | 0 | None | -14 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 541 | 3 | 1 | 6 | 6.3 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | 10.1021/ml200304j | ||
| CHEMBL2164577 | 88647 | 0 | None | -14 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 541 | 3 | 1 | 6 | 6.3 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | 10.1021/ml200304j | ||
| 46881509 | 14373 | 0 | None | 22 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1087933 | 14373 | 0 | None | 22 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46885311 | 15087 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092730 | 15087 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884576 | 14883 | 0 | None | 4 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091598 | 14883 | 0 | None | 4 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884578 | 14952 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091984 | 14952 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884630 | 15192 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093459 | 15192 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884659 | 14589 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089511 | 14589 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25026056 | 14953 | 0 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091985 | 14953 | 0 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25025861 | 15152 | 0 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093184 | 15152 | 0 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46887949 | 15592 | 0 | None | 9 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 342 | 2 | 2 | 5 | 2.9 | CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096819 | 15592 | 0 | None | 9 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 342 | 2 | 2 | 5 | 2.9 | CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1 | 10.1016/j.bmcl.2010.03.065 | ||
| 25025862 | 14593 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089521 | 14593 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25026056 | 14953 | 0 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091985 | 14953 | 0 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25025858 | 14554 | 0 | None | -16 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 362 | 6 | 2 | 2 | 5.1 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089383 | 14554 | 0 | None | -16 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 362 | 6 | 2 | 2 | 5.1 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884661 | 14590 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089512 | 14590 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884688 | 14945 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091918 | 14945 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618681 | 89563 | 0 | None | 14 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 512 | 2 | 1 | 5 | 6.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179918 | 89563 | 0 | None | 14 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 512 | 2 | 1 | 5 | 6.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | 10.1021/ml200207w | ||
| 46884659 | 14589 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089511 | 14589 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884659 | 14589 | 0 | None | 3 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089511 | 14589 | 0 | None | 3 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884661 | 14590 | 0 | None | 3 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089512 | 14590 | 0 | None | 3 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884627 | 15149 | 0 | None | 3 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093170 | 15149 | 0 | None | 3 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46889210 | 14304 | 0 | None | 1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 387 | 6 | 2 | 2 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087443 | 14304 | 0 | None | 1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 387 | 6 | 2 | 2 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46881416 | 13937 | 0 | None | 18 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 382 | 7 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1085434 | 13937 | 0 | None | 18 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 382 | 7 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618811 | 89559 | 0 | None | 6 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 461 | 2 | 1 | 4 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179914 | 89559 | 0 | None | 6 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 461 | 2 | 1 | 4 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1021/ml200207w | ||
| 59618620 | 89562 | 0 | None | 7 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 476 | 2 | 1 | 5 | 5.6 | Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179917 | 89562 | 0 | None | 7 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 476 | 2 | 1 | 5 | 5.6 | Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 54584418 | 67603 | 0 | None | 6 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762249 | 67603 | 0 | None | 6 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46884663 | 14595 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089523 | 14595 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25025862 | 14593 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089521 | 14593 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707363 | 88648 | 0 | None | 8 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 544 | 3 | 2 | 5 | 6.3 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164578 | 88648 | 0 | None | 8 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 544 | 3 | 2 | 5 | 6.3 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | 10.1021/ml200304j | ||
| 46884629 | 15151 | 0 | None | 2 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093183 | 15151 | 0 | None | 2 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707363 | 88648 | 0 | None | -8 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 544 | 3 | 2 | 5 | 6.3 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164578 | 88648 | 0 | None | -8 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 544 | 3 | 2 | 5 | 6.3 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | 10.1021/ml200304j | ||
| 46882013 | 12377 | 0 | None | -7 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 390 | 10 | 2 | 2 | 6.2 | CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1077345 | 12377 | 0 | None | -7 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 390 | 10 | 2 | 2 | 6.2 | CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884660 | 13214 | 0 | None | 1 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1082471 | 13214 | 0 | None | 1 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884628 | 15025 | 0 | None | 1 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092381 | 15025 | 0 | None | 1 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46881642 | 14868 | 0 | None | -12 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.1 | CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1091468 | 14868 | 0 | None | -12 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.1 | CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884662 | 14594 | 0 | None | 6 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089522 | 14594 | 0 | None | 6 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46889177 | 14256 | 0 | None | 10 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 497 | 10 | 2 | 4 | 6.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087066 | 14256 | 0 | None | 10 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 497 | 10 | 2 | 4 | 6.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46889233 | 14429 | 0 | None | -1 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 383 | 8 | 2 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088409 | 14429 | 0 | None | -1 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 383 | 8 | 2 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 66901749 | 89556 | 0 | None | -18 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179911 | 89556 | 0 | None | -18 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 54585379 | 67613 | 0 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762261 | 67613 | 0 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54583454 | 67625 | 0 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762273 | 67625 | 0 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 90663970 | 113568 | 0 | None | 12 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 553 | 14 | 5 | 4 | 2.5 | NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144503 | 113568 | 0 | None | 12 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 553 | 14 | 5 | 4 | 2.5 | NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46884662 | 14594 | 0 | None | 6 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089522 | 14594 | 0 | None | 6 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618658 | 89441 | 0 | None | 2 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179481 | 89441 | 0 | None | 2 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46887981 | 15862 | 0 | None | 28 | 2 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 418 | 5 | 2 | 5 | 3.9 | CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1099123 | 15862 | 0 | None | 28 | 2 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 418 | 5 | 2 | 5 | 3.9 | CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46888018 | 15834 | 0 | None | -2 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 460 | 5 | 2 | 5 | 4.9 | CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098837 | 15834 | 0 | None | -2 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 460 | 5 | 2 | 5 | 4.9 | CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46885312 | 14873 | 0 | None | -10 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091553 | 14873 | 0 | None | -10 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46881471 | 13233 | 0 | None | -13 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1082543 | 13233 | 0 | None | -13 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46889177 | 14256 | 0 | None | -10 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 497 | 10 | 2 | 4 | 6.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087066 | 14256 | 0 | None | -10 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 497 | 10 | 2 | 4 | 6.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 59618681 | 89563 | 0 | None | -14 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 512 | 2 | 1 | 5 | 6.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179918 | 89563 | 0 | None | -14 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 512 | 2 | 1 | 5 | 6.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | 10.1021/ml200207w | ||
| 46887980 | 15861 | 0 | None | 24 | 2 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 404 | 4 | 2 | 5 | 3.5 | CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1099122 | 15861 | 0 | None | 24 | 2 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 404 | 4 | 2 | 5 | 3.5 | CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46889235 | 14431 | 0 | None | 2 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 406 | 8 | 2 | 4 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088411 | 14431 | 0 | None | 2 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 406 | 8 | 2 | 4 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 25026058 | 14441 | 0 | None | 2 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 377 | 7 | 2 | 3 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088553 | 14441 | 0 | None | 2 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 377 | 7 | 2 | 3 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 54580461 | 67604 | 0 | None | 4 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 380 | 6 | 3 | 5 | 2.9 | CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762250 | 67604 | 0 | None | 4 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 380 | 6 | 3 | 5 | 2.9 | CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46200989 | 9340 | 15 | None | -9 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1021/ml200304j | ||
| 8502 | 9340 | 15 | None | -9 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1021/ml200304j | ||
| CHEMBL2023109 | 9340 | 15 | None | -9 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1021/ml200304j | ||
| 46200989 | 9340 | 15 | None | -9 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | ||
| 8502 | 9340 | 15 | None | -9 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023109 | 9340 | 15 | None | -9 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | ||
| 54583450 | 67612 | 0 | None | 3 | 2 | Mouse | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 3.0 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762259 | 67612 | 0 | None | 3 | 2 | Mouse | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 3.0 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21 | 10.1016/j.bmcl.2011.02.011 | ||
| 46884577 | 14884 | 0 | None | -2 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091599 | 14884 | 0 | None | -2 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618635 | 89443 | 0 | None | 6 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 435 | 2 | 1 | 4 | 5.8 | Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2 | 10.1021/ml200207w | ||
| CHEMBL2179484 | 89443 | 0 | None | 6 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 435 | 2 | 1 | 4 | 5.8 | Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2 | 10.1021/ml200207w | ||
| 46881417 | 13989 | 0 | None | -7 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 396 | 8 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1085670 | 13989 | 0 | None | -7 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 396 | 8 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46889146 | 14455 | 0 | None | -1 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 348 | 7 | 2 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088684 | 14455 | 0 | None | -1 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 348 | 7 | 2 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46884688 | 14945 | 0 | None | 1 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091918 | 14945 | 0 | None | 1 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25025654 | 7358 | 13 | None | -15 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| 6189 | 7358 | 13 | None | -15 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| 8506 | 7358 | 13 | None | -15 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084942 | 7358 | 13 | None | -15 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| 62707528 | 88562 | 0 | None | -11 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| CHEMBL2164222 | 88562 | 0 | None | -11 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| 71451990 | 89560 | 0 | None | -6 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 6.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179915 | 89560 | 0 | None | -6 | 2 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 6.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | 10.1021/ml200207w | ||
| 25025862 | 14593 | 0 | None | -2 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089521 | 14593 | 0 | None | -2 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 49871766 | 9335 | 40 | None | -17 | 5 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| 6170 | 9335 | 40 | None | -17 | 5 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| CHEMBL1672354 | 9335 | 40 | None | -17 | 5 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| 25026044 | 64616 | 1 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 390 | 6 | 2 | 4 | 3.9 | CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1 | 10.1021/ml100196d | ||
| CHEMBL1671874 | 64616 | 1 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 390 | 6 | 2 | 4 | 3.9 | CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1 | 10.1021/ml100196d | ||
| 46885312 | 14873 | 0 | None | 10 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091553 | 14873 | 0 | None | 10 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46881604 | 15642 | 0 | None | 25 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 374 | 6 | 2 | 2 | 5.6 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1097362 | 15642 | 0 | None | 25 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 374 | 6 | 2 | 2 | 5.6 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 90663956 | 113554 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 530 | 11 | 4 | 3 | 4.0 | C[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144489 | 113554 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 530 | 11 | 4 | 3 | 4.0 | C[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 90663965 | 113563 | 0 | None | 8 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 587 | 14 | 5 | 4 | 3.2 | NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144498 | 113563 | 0 | None | 8 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 587 | 14 | 5 | 4 | 3.2 | NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 4594 | 49646 | 127 | None | -4 | 6 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 345 | 5 | 1 | 5 | 2.9 | COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL1503 | 49646 | 127 | None | -4 | 6 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 345 | 5 | 1 | 5 | 2.9 | COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 46887766 | 15467 | 0 | None | 6 | 2 | Rat | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095741 | 15467 | 0 | None | 6 | 2 | Rat | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.5 | Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 25134007 | 88564 | 0 | None | -87 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 573 | 5 | 2 | 8 | 6.0 | CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164224 | 88564 | 0 | None | -87 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 573 | 5 | 2 | 8 | 6.0 | CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | ||
| 59618675 | 89439 | 0 | None | -2 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 497 | 1 | 1 | 5 | 4.8 | Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179479 | 89439 | 0 | None | -2 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 497 | 1 | 1 | 5 | 4.8 | Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46885313 | 14874 | 0 | None | -3 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091554 | 14874 | 0 | None | -3 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46889234 | 14430 | 0 | None | 1 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 407 | 8 | 2 | 5 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088410 | 14430 | 0 | None | 1 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 407 | 8 | 2 | 5 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 56840673 | 7924 | 0 | None | 2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| 8503 | 7924 | 0 | None | 2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| CHEMBL2164575 | 7924 | 0 | None | 2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| 59618711 | 80969 | 0 | None | 3 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 600 | 5 | 2 | 6 | 5.6 | CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023114 | 80969 | 0 | None | 3 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 600 | 5 | 2 | 6 | 5.6 | CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| 46884578 | 14952 | 0 | None | 3 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091984 | 14952 | 0 | None | 3 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 44300408 | 203583 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 455 | 10 | 5 | 3 | 3.4 | O=C(NNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL56562 | 203583 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 455 | 10 | 5 | 3 | 3.4 | O=C(NNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44300286 | 103334 | 0 | None | -1 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 1106 | 31 | 11 | 12 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O | 10.1021/jm0210921 | ||
| CHEMBL262992 | 103334 | 0 | None | -1 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 1106 | 31 | 11 | 12 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O | 10.1021/jm0210921 | ||
| 59618623 | 89434 | 0 | None | 2 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 501 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179474 | 89434 | 0 | None | 2 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 501 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 59618785 | 89440 | 0 | None | -3 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179480 | 89440 | 0 | None | -3 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46888017 | 15833 | 0 | None | -24 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 446 | 4 | 2 | 5 | 4.5 | CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098836 | 15833 | 0 | None | -24 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 446 | 4 | 2 | 5 | 4.5 | CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 66901760 | 89557 | 0 | None | -10 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 495 | 2 | 1 | 4 | 6.5 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179912 | 89557 | 0 | None | -10 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 495 | 2 | 1 | 4 | 6.5 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | 10.1021/ml200207w | ||
| 59618785 | 89440 | 0 | None | 3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179480 | 89440 | 0 | None | 3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46881473 | 14448 | 0 | None | -19 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1088614 | 14448 | 0 | None | -19 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 25026446 | 64720 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 338 | 5 | 2 | 4 | 3.6 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1 | 10.1021/ml100196d | ||
| CHEMBL1672353 | 64720 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 338 | 5 | 2 | 4 | 3.6 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1 | 10.1021/ml100196d | ||
| 25025861 | 15152 | 0 | None | -1 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093184 | 15152 | 0 | None | -1 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46889234 | 14430 | 0 | None | -1 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 407 | 8 | 2 | 5 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088410 | 14430 | 0 | None | -1 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 407 | 8 | 2 | 5 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46889145 | 15848 | 0 | None | 1 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 398 | 7 | 2 | 4 | 4.8 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1099034 | 15848 | 0 | None | 1 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 398 | 7 | 2 | 4 | 4.8 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1 | 10.1016/j.bmcl.2010.03.028 | ||
| 54581470 | 67602 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762248 | 67602 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54583452 | 67621 | 0 | None | 7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 399 | 5 | 2 | 4 | 4.8 | CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762269 | 67621 | 0 | None | 7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 399 | 5 | 2 | 4 | 4.8 | CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1 | 10.1016/j.bmcl.2011.02.011 | ||
| 54586337 | 67614 | 0 | None | -3 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762262 | 67614 | 0 | None | -3 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 44589824 | 193470 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 330 | 6 | 1 | 5 | 3.9 | COc1cc(CSc2nc3ccc(OC)cc3[nH]2)cc(OC)c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL488400 | 193470 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 330 | 6 | 1 | 5 | 3.9 | COc1cc(CSc2nc3ccc(OC)cc3[nH]2)cc(OC)c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 46881558 | 14105 | 0 | None | -31 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1086177 | 14105 | 0 | None | -31 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618811 | 89559 | 0 | None | -6 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 2 | 1 | 4 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179914 | 89559 | 0 | None | -6 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 2 | 1 | 4 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1021/ml200207w | ||
| 46881507 | 14237 | 0 | None | 16 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1086912 | 14237 | 0 | None | 16 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881418 | 13534 | 0 | None | 10 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1083825 | 13534 | 0 | None | 10 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46882013 | 12377 | 0 | None | 7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 390 | 10 | 2 | 2 | 6.2 | CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1077345 | 12377 | 0 | None | 7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 390 | 10 | 2 | 2 | 6.2 | CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884627 | 15149 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093170 | 15149 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 44300427 | 204394 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 468 | 12 | 4 | 3 | 3.4 | O=C(CNCCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL57068 | 204394 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 468 | 12 | 4 | 3 | 3.4 | O=C(CNCCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 54583454 | 67625 | 0 | None | 3 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762273 | 67625 | 0 | None | 3 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54586335 | 67608 | 0 | None | -12 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762254 | 67608 | 0 | None | -12 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| 54582478 | 67626 | 0 | None | -3 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762274 | 67626 | 0 | None | -3 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46884688 | 14945 | 0 | None | -1 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091918 | 14945 | 0 | None | -1 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618620 | 89562 | 0 | None | -7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 476 | 2 | 1 | 5 | 5.6 | Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179917 | 89562 | 0 | None | -7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 476 | 2 | 1 | 5 | 5.6 | Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46889175 | 14213 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1086673 | 14213 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46881418 | 13534 | 0 | None | -10 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1083825 | 13534 | 0 | None | -10 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881417 | 13989 | 0 | None | 7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 396 | 8 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1085670 | 13989 | 0 | None | 7 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 396 | 8 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46882011 | 12663 | 0 | None | 1 | 3 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079517 | 12663 | 0 | None | 1 | 3 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46889147 | 14456 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 445 | 7 | 1 | 5 | 5.7 | O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088685 | 14456 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 445 | 7 | 1 | 5 | 5.7 | O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46881510 | 14386 | 0 | None | -18 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1088062 | 14386 | 0 | None | -18 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54585380 | 67618 | 0 | None | 3 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762266 | 67618 | 0 | None | 3 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| 46881921 | 14829 | 0 | None | 15 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.5 | CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1091087 | 14829 | 0 | None | 15 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.5 | CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46882011 | 12663 | 0 | None | -15 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079517 | 12663 | 0 | None | -15 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 25026056 | 14953 | 0 | None | -1 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091985 | 14953 | 0 | None | -1 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 44387452 | 67283 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 538 | 9 | 6 | 4 | 3.0 | O=C(CC1NCCc2ccccc21)NNC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL175651 | 67283 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 538 | 9 | 6 | 4 | 3.0 | O=C(CC1NCCc2ccccc21)NNC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 54582478 | 67626 | 0 | None | 3 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762274 | 67626 | 0 | None | 3 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46882011 | 12663 | 0 | None | -15 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1021/ml100196d | ||
| CHEMBL1079517 | 12663 | 0 | None | -15 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1021/ml100196d | ||
| 46884629 | 15151 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093183 | 15151 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 71460964 | 89558 | 0 | None | 11 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179913 | 89558 | 0 | None | 11 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 90663968 | 113566 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 496 | 11 | 4 | 3 | 3.3 | C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144501 | 113566 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 496 | 11 | 4 | 3 | 3.3 | C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 49871766 | 9335 | 40 | None | 6 | 5 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| 6170 | 9335 | 40 | None | 6 | 5 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| CHEMBL1672354 | 9335 | 40 | None | 6 | 5 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| 44300379 | 107823 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 522 | 9 | 6 | 3 | 3.5 | O=C(Cc1cc2ccccc2[nH]1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL294647 | 107823 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 522 | 9 | 6 | 3 | 3.5 | O=C(Cc1cc2ccccc2[nH]1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 25025860 | 7357 | 32 | None | -4 | 5 | Mouse | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 6188 | 7357 | 32 | None | -4 | 5 | Mouse | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091720 | 7357 | 32 | None | -4 | 5 | Mouse | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 25025863 | 15271 | 0 | None | 4 | 2 | Mouse | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 430 | 10 | 2 | 5 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1094054 | 15271 | 0 | None | 4 | 2 | Mouse | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 430 | 10 | 2 | 5 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 44300436 | 204348 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 488 | 11 | 4 | 3 | 4.0 | O=C(CNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL57039 | 204348 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 488 | 11 | 4 | 3 | 4.0 | O=C(CNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46881470 | 13232 | 0 | None | 40 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1082542 | 13232 | 0 | None | 40 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54582477 | 67622 | 0 | None | 11 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 406 | 5 | 2 | 6 | 4.2 | CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762270 | 67622 | 0 | None | 11 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 406 | 5 | 2 | 6 | 4.2 | CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| 71460937 | 89437 | 0 | None | -10 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 493 | 3 | 1 | 4 | 6.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179477 | 89437 | 0 | None | -10 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 493 | 3 | 1 | 4 | 6.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46881416 | 13937 | 0 | None | -18 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 382 | 7 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1085434 | 13937 | 0 | None | -18 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 382 | 7 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 71451991 | 89561 | 0 | None | -15 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 477 | 2 | 2 | 5 | 5.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179916 | 89561 | 0 | None | -15 | 2 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 477 | 2 | 2 | 5 | 5.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | 10.1021/ml200207w | ||
| 59618746 | 80968 | 0 | None | 6 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 586 | 5 | 2 | 6 | 5.4 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023113 | 80968 | 0 | None | 6 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 586 | 5 | 2 | 6 | 5.4 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| 49871766 | 9335 | 40 | None | -6 | 5 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| 6170 | 9335 | 40 | None | -6 | 5 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| CHEMBL1672354 | 9335 | 40 | None | -6 | 5 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | ||
| 53242205 | 67601 | 0 | None | 3 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762247 | 67601 | 0 | None | 3 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 44300429 | 107424 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 455 | 11 | 4 | 4 | 2.7 | O=C(CNCc1cccnc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL292176 | 107424 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 455 | 11 | 4 | 4 | 2.7 | O=C(CNCc1cccnc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44300505 | 169909 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 454 | 11 | 4 | 3 | 3.3 | O=C(CNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL417767 | 169909 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 454 | 11 | 4 | 3 | 3.3 | O=C(CNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44589872 | 179502 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 330 | 4 | 1 | 4 | 3.7 | COc1ccc2nc(CCc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL450593 | 179502 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 330 | 4 | 1 | 4 | 3.7 | COc1ccc2nc(CCc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 54582477 | 67622 | 0 | None | -11 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 406 | 5 | 2 | 6 | 4.2 | CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762270 | 67622 | 0 | None | -11 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 406 | 5 | 2 | 6 | 4.2 | CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46888020 | 15868 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 460 | 6 | 2 | 5 | 4.9 | CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1099135 | 15868 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 460 | 6 | 2 | 5 | 4.9 | CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 59618675 | 89439 | 0 | None | 2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 497 | 1 | 1 | 5 | 4.8 | Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179479 | 89439 | 0 | None | 2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 497 | 1 | 1 | 5 | 4.8 | Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46884576 | 14883 | 0 | None | 4 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091598 | 14883 | 0 | None | 4 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618746 | 80968 | 0 | None | -6 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 586 | 5 | 2 | 6 | 5.4 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023113 | 80968 | 0 | None | -6 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 586 | 5 | 2 | 6 | 5.4 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| 59618711 | 80969 | 0 | None | -3 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 600 | 5 | 2 | 6 | 5.6 | CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023114 | 80969 | 0 | None | -3 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 600 | 5 | 2 | 6 | 5.6 | CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | ||
| 46882010 | 12834 | 0 | None | 13 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1080581 | 12834 | 0 | None | 13 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 25055504 | 64718 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | ||
| CHEMBL1672351 | 64718 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | ||
| 54581471 | 67606 | 0 | None | -6 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 444 | 5 | 3 | 5 | 3.6 | O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762252 | 67606 | 0 | None | -6 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 444 | 5 | 3 | 5 | 3.6 | O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 4157547 | 32001 | 9 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1348293 | 32001 | 9 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46882057 | 12694 | 0 | None | 2 | 2 | Mouse | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 6.1 | CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079696 | 12694 | 0 | None | 2 | 2 | Mouse | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 6.1 | CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881509 | 14373 | 0 | None | -22 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1087933 | 14373 | 0 | None | -22 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881605 | 15643 | 0 | None | 14 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 390 | 7 | 2 | 3 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1097363 | 15643 | 0 | None | 14 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 390 | 7 | 2 | 3 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 90663969 | 113567 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 601 | 15 | 5 | 4 | 3.6 | NC(=O)CC[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144502 | 113567 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 601 | 15 | 5 | 4 | 3.6 | NC(=O)CC[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 59618635 | 89443 | 0 | None | -6 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 435 | 2 | 1 | 4 | 5.8 | Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2 | 10.1021/ml200207w | ||
| CHEMBL2179484 | 89443 | 0 | None | -6 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 435 | 2 | 1 | 4 | 5.8 | Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2 | 10.1021/ml200207w | ||
| 46882011 | 12663 | 0 | None | -1 | 3 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079517 | 12663 | 0 | None | -1 | 3 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46889233 | 14429 | 0 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 383 | 8 | 2 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088409 | 14429 | 0 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 383 | 8 | 2 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 44300796 | 169966 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 445 | 10 | 5 | 4 | 3.0 | O=C(NNCc1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL418147 | 169966 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 445 | 10 | 5 | 4 | 3.0 | O=C(NNCc1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44589929 | 196214 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 370 | 3 | 1 | 4 | 4.5 | FC(F)(F)c1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL513374 | 196214 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 370 | 3 | 1 | 4 | 4.5 | FC(F)(F)c1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 44300456 | 107342 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 453 | 9 | 4 | 3 | 3.8 | O=C(N/N=C/c1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL291549 | 107342 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 453 | 9 | 4 | 3 | 3.8 | O=C(N/N=C/c1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 59618646 | 89442 | 0 | None | -2 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 421 | 2 | 1 | 4 | 5.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179482 | 89442 | 0 | None | -2 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 421 | 2 | 1 | 4 | 5.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2 | 10.1021/ml200207w | ||
| 46845425 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 8504 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089721 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 46845425 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | ||
| 8504 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1089721 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | ||
| 46884687 | 14944 | 0 | None | 3 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091917 | 14944 | 0 | None | 3 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46845425 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.01.154 | ||
| 8504 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089721 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.01.154 | ||
| 90663958 | 113556 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 482 | 12 | 4 | 3 | 3.8 | C[C@H](NCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144491 | 113556 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 482 | 12 | 4 | 3 | 3.8 | C[C@H](NCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 25129212 | 80967 | 0 | None | 7 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 574 | 5 | 2 | 6 | 5.2 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023112 | 80967 | 0 | None | 7 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 574 | 5 | 2 | 6 | 5.2 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1016/j.bmc.2012.03.029 | ||
| 46884629 | 15151 | 0 | None | 2 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093183 | 15151 | 0 | None | 2 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 54587369 | 67607 | 0 | None | 1 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 354 | 4 | 3 | 5 | 2.6 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762253 | 67607 | 0 | None | 1 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 354 | 4 | 3 | 5 | 2.6 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1 | 10.1016/j.bmcl.2011.02.011 | ||
| 54583452 | 67621 | 0 | None | -7 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 399 | 5 | 2 | 4 | 4.8 | CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762269 | 67621 | 0 | None | -7 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 399 | 5 | 2 | 4 | 4.8 | CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46882012 | 12664 | 0 | None | -5 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 404 | 11 | 2 | 2 | 6.6 | CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079518 | 12664 | 0 | None | -5 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 404 | 11 | 2 | 2 | 6.6 | CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881507 | 14237 | 0 | None | -16 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1086912 | 14237 | 0 | None | -16 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46889232 | 14285 | 0 | None | 1 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 401 | 6 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087200 | 14285 | 0 | None | 1 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 401 | 6 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 25129212 | 80967 | 0 | None | -7 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 574 | 5 | 2 | 6 | 5.2 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023112 | 80967 | 0 | None | -7 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 574 | 5 | 2 | 6 | 5.2 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1016/j.bmc.2012.03.029 | ||
| 54583453 | 67623 | 0 | None | 3 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 389 | 5 | 3 | 5 | 3.5 | CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762271 | 67623 | 0 | None | 3 | 2 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 389 | 5 | 3 | 5 | 3.5 | CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1 | 10.1016/j.bmcl.2011.02.011 | ||
| 44300482 | 204360 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 487 | 9 | 4 | 3 | 4.4 | O=C(N/N=C/c1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL57046 | 204360 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 487 | 9 | 4 | 3 | 4.4 | O=C(N/N=C/c1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46881961 | 12603 | 0 | None | -28 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 348 | 8 | 2 | 2 | 4.9 | CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079114 | 12603 | 0 | None | -28 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 348 | 8 | 2 | 2 | 4.9 | CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881920 | 15096 | 0 | None | -7 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 376 | 9 | 2 | 2 | 5.9 | CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1092798 | 15096 | 0 | None | -7 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 376 | 9 | 2 | 2 | 5.9 | CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881644 | 14615 | 0 | None | 1 | 2 | Mouse | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 348 | 5 | 2 | 2 | 4.9 | CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089720 | 14615 | 0 | None | 1 | 2 | Mouse | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 348 | 5 | 2 | 2 | 4.9 | CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881921 | 14829 | 0 | None | -15 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.5 | CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1091087 | 14829 | 0 | None | -15 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 362 | 8 | 2 | 2 | 5.5 | CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618710 | 89555 | 0 | None | 7 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 473 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179910 | 89555 | 0 | None | 7 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 473 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2 | 10.1021/ml200207w | ||
| 46884688 | 14945 | 0 | None | 1 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091918 | 14945 | 0 | None | 1 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 53242205 | 67601 | 0 | None | 3 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762247 | 67601 | 0 | None | 3 | 2 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46889210 | 14304 | 0 | None | -1 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 387 | 6 | 2 | 2 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087443 | 14304 | 0 | None | -1 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 387 | 6 | 2 | 2 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46882010 | 12834 | 0 | None | -13 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1080581 | 12834 | 0 | None | -13 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884630 | 15192 | 0 | None | 2 | 2 | Mouse | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093459 | 15192 | 0 | None | 2 | 2 | Mouse | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 44300356 | 205026 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 483 | 9 | 5 | 3 | 3.0 | O=C(Cc1ccccc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL57559 | 205026 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 483 | 9 | 5 | 3 | 3.0 | O=C(Cc1ccccc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46884628 | 15025 | 0 | None | 1 | 2 | Mouse | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092381 | 15025 | 0 | None | 1 | 2 | Mouse | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL525577 | 222432 | 0 | None | -64 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O | 10.1016/j.bmcl.2008.09.033 | ||||
| 25025863 | 15271 | 0 | None | -4 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 430 | 10 | 2 | 5 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1094054 | 15271 | 0 | None | -4 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 430 | 10 | 2 | 5 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46881683 | 15134 | 0 | None | 2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 5.9 | CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1093080 | 15134 | 0 | None | 2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 5.9 | CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 44300275 | 208320 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 522 | 11 | 3 | 3 | 4.5 | O=C(CN1CCC(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL60537 | 208320 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 522 | 11 | 3 | 3 | 4.5 | O=C(CN1CCC(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46884578 | 14952 | 0 | None | -3 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091984 | 14952 | 0 | None | -3 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46885313 | 14874 | 0 | None | 3 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091554 | 14874 | 0 | None | 3 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46881508 | 14238 | 0 | None | 26 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1086913 | 14238 | 0 | None | 26 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 90663963 | 113561 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 551 | 11 | 5 | 4 | 3.3 | C[C@H](NC(=O)CC1NCCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144496 | 113561 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 551 | 11 | 5 | 4 | 3.3 | C[C@H](NC(=O)CC1NCCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46887980 | 15861 | 0 | None | -24 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 404 | 4 | 2 | 5 | 3.5 | CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1099122 | 15861 | 0 | None | -24 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 404 | 4 | 2 | 5 | 3.5 | CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 90663967 | 113565 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 497 | 11 | 4 | 4 | 2.7 | C[C@H](NC(=O)Cc1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144500 | 113565 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 497 | 11 | 4 | 4 | 2.7 | C[C@H](NC(=O)Cc1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 54585379 | 67613 | 0 | None | 3 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762261 | 67613 | 0 | None | 3 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54586337 | 67614 | 0 | None | 3 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762262 | 67614 | 0 | None | 3 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 59618646 | 89442 | 0 | None | 2 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 421 | 2 | 1 | 4 | 5.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179482 | 89442 | 0 | None | 2 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 421 | 2 | 1 | 4 | 5.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2 | 10.1021/ml200207w | ||
| 54580463 | 67609 | 0 | None | 11 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762255 | 67609 | 0 | None | 11 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| 56840673 | 7924 | 0 | None | -2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| 8503 | 7924 | 0 | None | -2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| CHEMBL2164575 | 7924 | 0 | None | -2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| 46881603 | 15904 | 0 | None | 19 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 402 | 8 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1099370 | 15904 | 0 | None | 19 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 402 | 8 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 136086809 | 14215 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 445 | 10 | 3 | 4 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1086684 | 14215 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 445 | 10 | 3 | 4 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46881605 | 15643 | 0 | None | -14 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 7 | 2 | 3 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1097363 | 15643 | 0 | None | -14 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 7 | 2 | 3 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46889146 | 14455 | 0 | None | 1 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 348 | 7 | 2 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088684 | 14455 | 0 | None | 1 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 348 | 7 | 2 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 54581472 | 67615 | 0 | None | 18 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 365 | 4 | 3 | 4 | 3.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762263 | 67615 | 0 | None | 18 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 365 | 4 | 3 | 4 | 3.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881920 | 15096 | 0 | None | 7 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 376 | 9 | 2 | 2 | 5.9 | CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1092798 | 15096 | 0 | None | 7 | 2 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 376 | 9 | 2 | 2 | 5.9 | CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46887912 | 15797 | 0 | None | 16 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 396 | 3 | 2 | 5 | 3.7 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098513 | 15797 | 0 | None | 16 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 396 | 3 | 2 | 5 | 3.7 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887877 | 15744 | 0 | None | 19 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 363 | 3 | 2 | 6 | 2.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098188 | 15744 | 0 | None | 19 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 363 | 3 | 2 | 6 | 2.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887981 | 15862 | 0 | None | -28 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 418 | 5 | 2 | 5 | 3.9 | CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1099123 | 15862 | 0 | None | -28 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 418 | 5 | 2 | 5 | 3.9 | CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 54580462 | 67605 | 0 | None | -4 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 422 | 6 | 3 | 5 | 3.9 | CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762251 | 67605 | 0 | None | -4 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 422 | 6 | 3 | 5 | 3.9 | CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 44589874 | 195184 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 344 | 4 | 1 | 4 | 4.3 | COc1ccc2nc(C(C)Cc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL501895 | 195184 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 344 | 4 | 1 | 4 | 4.3 | COc1ccc2nc(C(C)Cc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 3288900 | 15726 | 8 | None | 2 | 2 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 364 | 3 | 2 | 6 | 1.9 | Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098098 | 15726 | 8 | None | 2 | 2 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 364 | 3 | 2 | 6 | 1.9 | Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46884628 | 15025 | 0 | None | -1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092381 | 15025 | 0 | None | -1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618710 | 89555 | 0 | None | -7 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 473 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179910 | 89555 | 0 | None | -7 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 473 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2 | 10.1021/ml200207w | ||
| 46881604 | 15642 | 0 | None | -25 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 374 | 6 | 2 | 2 | 5.6 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1097362 | 15642 | 0 | None | -25 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 374 | 6 | 2 | 2 | 5.6 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 71460964 | 89558 | 0 | None | -11 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179913 | 89558 | 0 | None | -11 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 59618709 | 89552 | 1 | None | 14 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179908 | 89552 | 1 | None | 14 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | 10.1021/ml200207w | ||
| 54582478 | 67626 | 0 | None | -3 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762274 | 67626 | 0 | None | -3 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 4254919 | 15428 | 9 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 362 | 3 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095423 | 15428 | 9 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 362 | 3 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 4581089 | 200680 | 5 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 348 | 4 | 1 | 5 | 4.2 | COc1ccc2nc(SCc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL527650 | 200680 | 5 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 348 | 4 | 1 | 5 | 4.2 | COc1ccc2nc(SCc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 46882059 | 12724 | 0 | None | 14 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 362 | 9 | 2 | 2 | 5.3 | CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079869 | 12724 | 0 | None | 14 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 362 | 9 | 2 | 2 | 5.3 | CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46887914 | 21002 | 0 | None | 2 | 2 | Rat | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.2 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1199153 | 21002 | 0 | None | 2 | 2 | Rat | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.2 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 54581471 | 67606 | 0 | None | 6 | 2 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 444 | 5 | 3 | 5 | 3.6 | O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762252 | 67606 | 0 | None | 6 | 2 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 444 | 5 | 3 | 5 | 3.6 | O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881643 | 14553 | 0 | None | -6 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 376 | 7 | 2 | 2 | 5.5 | CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089382 | 14553 | 0 | None | -6 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 376 | 7 | 2 | 2 | 5.5 | CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 155794 | 213412 | 97 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 329 | 5 | 1 | 5 | 3.9 | COc1ccc2nc(SCc3ncc(C)c(OC)c3C)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL892 | 213412 | 97 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 329 | 5 | 1 | 5 | 3.9 | COc1ccc2nc(SCc3ncc(C)c(OC)c3C)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 46889209 | 14303 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087442 | 14303 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 90663959 | 113557 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 502 | 11 | 4 | 3 | 4.4 | C[C@H](NCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144492 | 113557 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 502 | 11 | 4 | 3 | 4.4 | C[C@H](NCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46884577 | 14884 | 0 | None | 2 | 2 | Mouse | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091599 | 14884 | 0 | None | 2 | 2 | Mouse | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46889176 | 14214 | 0 | None | 10 | 2 | Mouse | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 444 | 10 | 3 | 5 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1086674 | 14214 | 0 | None | 10 | 2 | Mouse | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 444 | 10 | 3 | 5 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46885311 | 15087 | 0 | None | 2 | 2 | Mouse | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092730 | 15087 | 0 | None | 2 | 2 | Mouse | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707364 | 88650 | 0 | None | 8 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 529 | 3 | 1 | 7 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164580 | 88650 | 0 | None | 8 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 529 | 3 | 1 | 7 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | 10.1021/ml200304j | ||
| 54583453 | 67623 | 0 | None | -3 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 389 | 5 | 3 | 5 | 3.5 | CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762271 | 67623 | 0 | None | -3 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 389 | 5 | 3 | 5 | 3.5 | CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1 | 10.1016/j.bmcl.2011.02.011 | ||
| 54581474 | 67624 | 0 | None | -4 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 376 | 6 | 3 | 6 | 2.7 | CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762272 | 67624 | 0 | None | -4 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 376 | 6 | 3 | 6 | 2.7 | CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46887946 | 15563 | 0 | None | 25 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 406 | 3 | 2 | 7 | 2.8 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096546 | 15563 | 0 | None | 25 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 406 | 3 | 2 | 7 | 2.8 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46861857 | 14212 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 461 | 10 | 3 | 4 | 6.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1086672 | 14212 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 461 | 10 | 3 | 4 | 6.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46881601 | 15846 | 0 | None | -5 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 388 | 7 | 2 | 2 | 5.7 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1099032 | 15846 | 0 | None | -5 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 388 | 7 | 2 | 2 | 5.7 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54581474 | 67624 | 0 | None | 4 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 376 | 6 | 3 | 6 | 2.7 | CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762272 | 67624 | 0 | None | 4 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 376 | 6 | 3 | 6 | 2.7 | CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881962 | 12945 | 0 | None | -52 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081130 | 12945 | 0 | None | -52 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46888019 | 15835 | 0 | None | 1 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 458 | 5 | 2 | 5 | 4.6 | O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098838 | 15835 | 0 | None | 1 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 458 | 5 | 2 | 5 | 4.6 | O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1 | 10.1016/j.bmcl.2010.03.065 | ||
| 46888067 | 15445 | 0 | None | -6 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 5.0 | CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095529 | 15445 | 0 | None | -6 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 5.0 | CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 59618747 | 88646 | 0 | None | 6 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 538 | 3 | 1 | 5 | 6.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164576 | 88646 | 0 | None | 6 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 538 | 3 | 1 | 5 | 6.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | 10.1021/ml200304j | ||
| 46889235 | 14431 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 406 | 8 | 2 | 4 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088411 | 14431 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 406 | 8 | 2 | 4 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 25026058 | 14441 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 377 | 7 | 2 | 3 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088553 | 14441 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 377 | 7 | 2 | 3 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46884687 | 14944 | 0 | None | -3 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091917 | 14944 | 0 | None | -3 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884576 | 14883 | 0 | None | -4 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091598 | 14883 | 0 | None | -4 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618698 | 89436 | 0 | None | 6 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 517 | 3 | 1 | 5 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179476 | 89436 | 0 | None | 6 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 517 | 3 | 1 | 5 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 54580465 | 67611 | 0 | None | 1 | 2 | Mouse | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 390 | 5 | 3 | 5 | 3.2 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762258 | 67611 | 0 | None | 1 | 2 | Mouse | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 390 | 5 | 3 | 5 | 3.2 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881472 | 14434 | 0 | None | -56 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1088468 | 14434 | 0 | None | -56 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884661 | 14590 | 0 | None | -3 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089512 | 14590 | 0 | None | -3 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46888018 | 15834 | 0 | None | 2 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 460 | 5 | 2 | 5 | 4.9 | CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098837 | 15834 | 0 | None | 2 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 460 | 5 | 2 | 5 | 4.9 | CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46881644 | 14615 | 0 | None | -1 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 348 | 5 | 2 | 2 | 4.9 | CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089720 | 14615 | 0 | None | -1 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 348 | 5 | 2 | 2 | 4.9 | CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46882060 | 13085 | 0 | None | 2 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 5.3 | CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081866 | 13085 | 0 | None | 2 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 5.3 | CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884660 | 13214 | 0 | None | -1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1082471 | 13214 | 0 | None | -1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 1214469 | 67599 | 1 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762245 | 67599 | 1 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54587369 | 67607 | 0 | None | -1 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 354 | 4 | 3 | 5 | 2.6 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762253 | 67607 | 0 | None | -1 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 354 | 4 | 3 | 5 | 2.6 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1 | 10.1016/j.bmcl.2011.02.011 | ||
| 54580463 | 67609 | 0 | None | -11 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762255 | 67609 | 0 | None | -11 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL403317 | 219309 | 27 | None | -6309 | 4 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm0210921 | ||||
| 4254919 | 15428 | 9 | None | -12 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 362 | 3 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095423 | 15428 | 9 | None | -12 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 362 | 3 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 90663962 | 113560 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 468 | 11 | 4 | 3 | 3.7 | C[C@H](NCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144495 | 113560 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 468 | 11 | 4 | 3 | 3.7 | C[C@H](NCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46882057 | 12694 | 0 | None | -2 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 6.1 | CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079696 | 12694 | 0 | None | -2 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 6.1 | CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 25025860 | 7357 | 32 | None | -14 | 5 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 6188 | 7357 | 32 | None | -14 | 5 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091720 | 7357 | 32 | None | -14 | 5 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 25025860 | 7357 | 32 | None | -14 | 5 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1021/ml100196d | ||
| 6188 | 7357 | 32 | None | -14 | 5 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1021/ml100196d | ||
| CHEMBL1091720 | 7357 | 32 | None | -14 | 5 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1021/ml100196d | ||
| 46888066 | 15444 | 0 | None | 21 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 390 | 5 | 2 | 5 | 3.9 | CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095528 | 15444 | 0 | None | 21 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 390 | 5 | 2 | 5 | 3.9 | CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887982 | 15516 | 0 | None | -47 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 4.1 | CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096193 | 15516 | 0 | None | -47 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 4.1 | CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46887824 | 15725 | 0 | None | 20 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.0 | Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098097 | 15725 | 0 | None | 20 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 380 | 3 | 2 | 5 | 3.0 | Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 25128865 | 89433 | 0 | None | 9 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 475 | 3 | 1 | 4 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179473 | 89433 | 0 | None | 9 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 475 | 3 | 1 | 4 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 54581470 | 67602 | 0 | None | 3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762248 | 67602 | 0 | None | 3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54584420 | 67616 | 0 | None | 1 | 2 | Mouse | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 2.9 | CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762264 | 67616 | 0 | None | 1 | 2 | Mouse | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 2.9 | CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46882061 | 13122 | 0 | None | -5 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 368 | 6 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1082041 | 13122 | 0 | None | -5 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 368 | 6 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881602 | 15847 | 0 | None | 15 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 402 | 7 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1099033 | 15847 | 0 | None | 15 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 402 | 7 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46861857 | 14212 | 0 | None | 2 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 461 | 10 | 3 | 4 | 6.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1086672 | 14212 | 0 | None | 2 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 461 | 10 | 3 | 4 | 6.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 59618678 | 89551 | 0 | None | 3 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 446 | 2 | 1 | 5 | 5.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179907 | 89551 | 0 | None | 3 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 446 | 2 | 1 | 5 | 5.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | 10.1021/ml200207w | ||
| 66901749 | 89556 | 0 | None | 18 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179911 | 89556 | 0 | None | 18 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 59618678 | 89551 | 0 | None | -3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 446 | 2 | 1 | 5 | 5.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179907 | 89551 | 0 | None | -3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 446 | 2 | 1 | 5 | 5.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | 10.1021/ml200207w | ||
| 46881558 | 14105 | 0 | None | 31 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1086177 | 14105 | 0 | None | 31 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54580461 | 67604 | 0 | None | -4 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 380 | 6 | 3 | 5 | 2.9 | CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762250 | 67604 | 0 | None | -4 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 380 | 6 | 3 | 5 | 2.9 | CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54582478 | 67626 | 0 | None | 3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762274 | 67626 | 0 | None | 3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 25110720 | 185607 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 332 | 4 | 1 | 5 | 3.5 | COc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL469313 | 185607 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 332 | 4 | 1 | 5 | 3.5 | COc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 46881963 | 12946 | 0 | None | 10 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081131 | 12946 | 0 | None | 10 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618790 | 88563 | 0 | None | 12 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 587 | 4 | 2 | 8 | 6.1 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164223 | 88563 | 0 | None | 12 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 587 | 4 | 2 | 8 | 6.1 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | ||
| 62707365 | 88652 | 0 | None | 11 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| CHEMBL2164582 | 88652 | 0 | None | 11 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| 46885313 | 14874 | 0 | None | -3 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091554 | 14874 | 0 | None | -3 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46882012 | 12664 | 0 | None | 5 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 404 | 11 | 2 | 2 | 6.6 | CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079518 | 12664 | 0 | None | 5 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 404 | 11 | 2 | 2 | 6.6 | CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881963 | 12946 | 0 | None | -10 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081131 | 12946 | 0 | None | -10 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884659 | 14589 | 0 | None | -3 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089511 | 14589 | 0 | None | -3 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46889148 | 14457 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 10 | 2 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1088686 | 14457 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 10 | 2 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 59618778 | 89435 | 0 | None | 2 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 511 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179475 | 89435 | 0 | None | 2 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 511 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46888020 | 15868 | 0 | None | -2 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 460 | 6 | 2 | 5 | 4.9 | CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1099135 | 15868 | 0 | None | -2 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 460 | 6 | 2 | 5 | 4.9 | CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46881419 | 13630 | 0 | None | -8 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084130 | 13630 | 0 | None | -8 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 53242205 | 67601 | 0 | None | -3 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762247 | 67601 | 0 | None | -3 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46887912 | 15797 | 0 | None | -16 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 396 | 3 | 2 | 5 | 3.7 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098513 | 15797 | 0 | None | -16 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 396 | 3 | 2 | 5 | 3.7 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46882059 | 12724 | 0 | None | -14 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 362 | 9 | 2 | 2 | 5.3 | CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079869 | 12724 | 0 | None | -14 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 362 | 9 | 2 | 2 | 5.3 | CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618753 | 88651 | 0 | None | 14 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 559 | 4 | 2 | 8 | 5.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164581 | 88651 | 0 | None | 14 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 559 | 4 | 2 | 8 | 5.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | 10.1021/ml200304j | ||
| 46889232 | 14285 | 0 | None | -1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 401 | 6 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1087200 | 14285 | 0 | None | -1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 401 | 6 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 46889145 | 15848 | 0 | None | -1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 398 | 7 | 2 | 4 | 4.8 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1099034 | 15848 | 0 | None | -1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 398 | 7 | 2 | 4 | 4.8 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1 | 10.1016/j.bmcl.2010.03.028 | ||
| 59618778 | 89435 | 0 | None | -2 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 511 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179475 | 89435 | 0 | None | -2 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 511 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46884663 | 14595 | 0 | None | 3 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089523 | 14595 | 0 | None | 3 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707364 | 88650 | 0 | None | -8 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 529 | 3 | 1 | 7 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164580 | 88650 | 0 | None | -8 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 529 | 3 | 1 | 7 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | 10.1021/ml200304j | ||
| 90663966 | 113564 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 592 | 14 | 6 | 4 | 3.0 | NC(=O)CC[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144499 | 113564 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 592 | 14 | 6 | 4 | 3.0 | NC(=O)CC[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46884662 | 14594 | 0 | None | -6 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089522 | 14594 | 0 | None | -6 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 44589928 | 185783 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 336 | 3 | 1 | 4 | 4.2 | Clc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| CHEMBL471016 | 185783 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 336 | 3 | 1 | 4 | 4.2 | Clc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1 | 10.1016/j.bmcl.2008.09.033 | ||
| 59618747 | 88646 | 0 | None | -6 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 538 | 3 | 1 | 5 | 6.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164576 | 88646 | 0 | None | -6 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 538 | 3 | 1 | 5 | 6.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | 10.1021/ml200304j | ||
| 46881561 | 13765 | 0 | None | -83 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 360 | 7 | 2 | 2 | 4.9 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084698 | 13765 | 0 | None | -83 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 360 | 7 | 2 | 2 | 4.9 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881964 | 12947 | 0 | None | -8 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081132 | 12947 | 0 | None | -8 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54584421 | 67617 | 0 | None | 13 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 367 | 4 | 2 | 6 | 2.9 | CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762265 | 67617 | 0 | None | 13 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 367 | 4 | 2 | 6 | 2.9 | CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 44300407 | 203701 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 489 | 10 | 5 | 3 | 4.1 | O=C(NNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL56626 | 203701 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 489 | 10 | 5 | 3 | 4.1 | O=C(NNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46881643 | 14553 | 0 | None | 6 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 376 | 7 | 2 | 2 | 5.5 | CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089382 | 14553 | 0 | None | 6 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 376 | 7 | 2 | 2 | 5.5 | CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 25025858 | 14554 | 0 | None | 16 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 362 | 6 | 2 | 2 | 5.1 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089383 | 14554 | 0 | None | 16 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 362 | 6 | 2 | 2 | 5.1 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884660 | 13214 | 0 | None | 1 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1082471 | 13214 | 0 | None | 1 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618730 | 89438 | 0 | None | 4 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 500 | 3 | 1 | 5 | 6.0 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179478 | 89438 | 0 | None | 4 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 500 | 3 | 1 | 5 | 6.0 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46888068 | 15447 | 0 | None | 1 | 2 | Rat | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 376 | 3 | 1 | 6 | 3.1 | Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095530 | 15447 | 0 | None | 1 | 2 | Rat | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 376 | 3 | 1 | 6 | 3.1 | Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46885311 | 15087 | 0 | None | -2 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092730 | 15087 | 0 | None | -2 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884630 | 15192 | 0 | None | -2 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093459 | 15192 | 0 | None | -2 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707362 | 88647 | 0 | None | 14 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 541 | 3 | 1 | 6 | 6.3 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | 10.1021/ml200304j | ||
| CHEMBL2164577 | 88647 | 0 | None | 14 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 541 | 3 | 1 | 6 | 6.3 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | 10.1021/ml200304j | ||
| 66901760 | 89557 | 0 | None | 10 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 495 | 2 | 1 | 4 | 6.5 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179912 | 89557 | 0 | None | 10 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 495 | 2 | 1 | 4 | 6.5 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | 10.1021/ml200207w | ||
| 46888017 | 15833 | 0 | None | 24 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 446 | 4 | 2 | 5 | 4.5 | CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098836 | 15833 | 0 | None | 24 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 446 | 4 | 2 | 5 | 4.5 | CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 59618821 | 80965 | 0 | None | 7 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 657 | 6 | 2 | 9 | 6.4 | CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023110 | 80965 | 0 | None | 7 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 657 | 6 | 2 | 9 | 6.4 | CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1016/j.bmc.2012.03.029 | ||
| 54585380 | 67618 | 0 | None | -3 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762266 | 67618 | 0 | None | -3 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| 54581472 | 67615 | 0 | None | -18 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 365 | 4 | 3 | 4 | 3.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762263 | 67615 | 0 | None | -18 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 365 | 4 | 3 | 4 | 3.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 90663961 | 113559 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 544 | 12 | 4 | 3 | 4.3 | C[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144494 | 113559 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 544 | 12 | 4 | 3 | 4.3 | C[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL438926 | 220590 | 19 | None | -190 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C(N)=O | 10.1021/jm0210921 | ||||
| 46884663 | 14595 | 0 | None | -3 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089523 | 14595 | 0 | None | -3 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46881603 | 15904 | 0 | None | -19 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 402 | 8 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1099370 | 15904 | 0 | None | -19 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 402 | 8 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881419 | 13630 | 0 | None | 8 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084130 | 13630 | 0 | None | 8 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54583451 | 67620 | 0 | None | 1 | 2 | Mouse | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762268 | 67620 | 0 | None | 1 | 2 | Mouse | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 25025861 | 15152 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093184 | 15152 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25025861 | 15152 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | ||
| CHEMBL1093184 | 15152 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | ||
| 25026445 | 64719 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | ||
| CHEMBL1672352 | 64719 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | ||
| 59618821 | 80965 | 0 | None | -7 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 657 | 6 | 2 | 9 | 6.4 | CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023110 | 80965 | 0 | None | -7 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 657 | 6 | 2 | 9 | 6.4 | CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1016/j.bmc.2012.03.029 | ||
| 46887877 | 15744 | 0 | None | -19 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 363 | 3 | 2 | 6 | 2.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098188 | 15744 | 0 | None | -19 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 363 | 3 | 2 | 6 | 2.5 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46888067 | 15445 | 0 | None | 6 | 2 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 5.0 | CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095529 | 15445 | 0 | None | 6 | 2 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 5.0 | CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 54583450 | 67612 | 0 | None | -3 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 3.0 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762259 | 67612 | 0 | None | -3 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 3.0 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21 | 10.1016/j.bmcl.2011.02.011 | ||
| 62707528 | 88562 | 0 | None | 11 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| CHEMBL2164222 | 88562 | 0 | None | 11 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| 71460937 | 89437 | 0 | None | 10 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 493 | 3 | 1 | 4 | 6.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179477 | 89437 | 0 | None | 10 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 493 | 3 | 1 | 4 | 6.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 54586336 | 67610 | 0 | None | 1 | 2 | Mouse | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 362 | 5 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762257 | 67610 | 0 | None | 1 | 2 | Mouse | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 362 | 5 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881561 | 13765 | 0 | None | 83 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 360 | 7 | 2 | 2 | 4.9 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084698 | 13765 | 0 | None | 83 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 360 | 7 | 2 | 2 | 4.9 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881601 | 15846 | 0 | None | 5 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 388 | 7 | 2 | 2 | 5.7 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1099032 | 15846 | 0 | None | 5 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 388 | 7 | 2 | 2 | 5.7 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 90663960 | 113558 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 540 | 11 | 4 | 5 | 3.0 | C[C@H](NC(=O)Cc1ccc2c(c1)OCO2)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144493 | 113558 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 540 | 11 | 4 | 5 | 3.0 | C[C@H](NC(=O)Cc1ccc2c(c1)OCO2)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 25025654 | 7358 | 13 | None | 1 | 3 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| 6189 | 7358 | 13 | None | 1 | 3 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| 8506 | 7358 | 13 | None | 1 | 3 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084942 | 7358 | 13 | None | 1 | 3 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46881473 | 14448 | 0 | None | 19 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1088614 | 14448 | 0 | None | 19 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 44300503 | 107677 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 523 | 11 | 3 | 4 | 3.4 | O=C(CN1CCN(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL293820 | 107677 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 523 | 11 | 3 | 4 | 3.4 | O=C(CN1CCN(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 54581473 | 67619 | 0 | None | 1 | 2 | Mouse | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 365 | 4 | 4 | 5 | 2.3 | CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762267 | 67619 | 0 | None | 1 | 2 | Mouse | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 365 | 4 | 4 | 5 | 2.3 | CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46888019 | 15835 | 0 | None | -1 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 458 | 5 | 2 | 5 | 4.6 | O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098838 | 15835 | 0 | None | -1 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 458 | 5 | 2 | 5 | 4.6 | O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1 | 10.1016/j.bmcl.2010.03.065 | ||
| 90663964 | 113562 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 582 | 15 | 6 | 5 | 1.9 | NC(=O)CC[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144497 | 113562 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 582 | 15 | 6 | 5 | 1.9 | NC(=O)CC[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46881560 | 13764 | 0 | None | 13 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084697 | 13764 | 0 | None | 13 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 346 | 7 | 2 | 2 | 4.5 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54584418 | 67603 | 0 | None | -6 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762249 | 67603 | 0 | None | -6 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881964 | 12947 | 0 | None | 8 | 2 | Mouse | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081132 | 12947 | 0 | None | 8 | 2 | Mouse | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46200989 | 9340 | 15 | None | 9 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | ||
| 8502 | 9340 | 15 | None | 9 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023109 | 9340 | 15 | None | 9 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | ||
| 46881472 | 14434 | 0 | None | 56 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1088468 | 14434 | 0 | None | 56 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| 54586336 | 67610 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 362 | 5 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762257 | 67610 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 362 | 5 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46888069 | 15655 | 0 | None | 13 | 2 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 404 | 3 | 1 | 7 | 3.2 | CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1097471 | 15655 | 0 | None | 13 | 2 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 404 | 3 | 1 | 7 | 3.2 | CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3 | 10.1016/j.bmcl.2010.03.065 | ||
| 136118727 | 88649 | 0 | None | -1 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 545 | 3 | 2 | 7 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164579 | 88649 | 0 | None | -1 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 545 | 3 | 2 | 7 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1 | 10.1021/ml200304j | ||
| 25128867 | 80966 | 0 | None | -10 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 669 | 6 | 2 | 9 | 6.5 | CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023111 | 80966 | 0 | None | -10 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 669 | 6 | 2 | 9 | 6.5 | CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1 | 10.1016/j.bmc.2012.03.029 | ||
| 46881683 | 15134 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 5.9 | CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1093080 | 15134 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 390 | 9 | 2 | 2 | 5.9 | CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46887875 | 15675 | 0 | None | 1 | 2 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 336 | 4 | 3 | 5 | 2.9 | CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1097551 | 15675 | 0 | None | 1 | 2 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 336 | 4 | 3 | 5 | 2.9 | CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| 136118727 | 88649 | 0 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 545 | 3 | 2 | 7 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164579 | 88649 | 0 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 545 | 3 | 2 | 7 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1 | 10.1021/ml200304j | ||
| 71451990 | 89560 | 0 | None | 6 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 6.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179915 | 89560 | 0 | None | 6 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 6.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | 10.1021/ml200207w | ||
| 46889176 | 14214 | 0 | None | -10 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 444 | 10 | 3 | 5 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1086674 | 14214 | 0 | None | -10 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 444 | 10 | 3 | 5 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | ||
| 25025860 | 7357 | 32 | None | -4 | 5 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 6188 | 7357 | 32 | None | -4 | 5 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091720 | 7357 | 32 | None | -4 | 5 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 59618623 | 89434 | 0 | None | -2 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 501 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179474 | 89434 | 0 | None | -2 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 501 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 59618730 | 89438 | 0 | None | -4 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 500 | 3 | 1 | 5 | 6.0 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179478 | 89438 | 0 | None | -4 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 500 | 3 | 1 | 5 | 6.0 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46881962 | 12945 | 0 | None | 52 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1081130 | 12945 | 0 | None | 52 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 412 | 8 | 2 | 3 | 5.2 | COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| 90663957 | 113555 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 535 | 11 | 5 | 3 | 3.8 | C[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL3144490 | 113555 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 535 | 11 | 5 | 3 | 3.8 | C[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 44300383 | 205470 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 535 | 10 | 4 | 4 | 5.5 | O=C(N/N=C/c1ccc(-c2cccs2)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL58097 | 205470 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 535 | 10 | 4 | 4 | 5.5 | O=C(N/N=C/c1ccc(-c2cccs2)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46887950 | 15801 | 0 | None | 1 | 2 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 376 | 4 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1098535 | 15801 | 0 | None | 1 | 2 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 376 | 4 | 2 | 5 | 3.1 | Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46881559 | 13763 | 0 | None | 10 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 418 | 7 | 2 | 2 | 5.4 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084696 | 13763 | 0 | None | 10 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 418 | 7 | 2 | 2 | 5.4 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618698 | 89436 | 0 | None | -6 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 3 | 1 | 5 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179476 | 89436 | 0 | None | -6 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 3 | 1 | 5 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 53242205 | 67601 | 0 | None | -3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762247 | 67601 | 0 | None | -3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54580465 | 67611 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 390 | 5 | 3 | 5 | 3.2 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762258 | 67611 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 390 | 5 | 3 | 5 | 3.2 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881470 | 13232 | 0 | None | -40 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1082542 | 13232 | 0 | None | -40 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 407 | 7 | 2 | 3 | 5.0 | N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1 | 10.1016/j.bmcl.2010.01.154 | ||
| 25128867 | 80966 | 0 | None | 10 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 669 | 6 | 2 | 9 | 6.5 | CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1 | 10.1016/j.bmc.2012.03.029 | ||
| CHEMBL2023111 | 80966 | 0 | None | 10 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 669 | 6 | 2 | 9 | 6.5 | CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1 | 10.1016/j.bmc.2012.03.029 | ||
| 54584421 | 67617 | 0 | None | -13 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 367 | 4 | 2 | 6 | 2.9 | CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762265 | 67617 | 0 | None | -13 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 367 | 4 | 2 | 6 | 2.9 | CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881508 | 14238 | 0 | None | -26 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1086913 | 14238 | 0 | None | -26 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 416 | 7 | 2 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 59618790 | 88563 | 0 | None | -12 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 587 | 4 | 2 | 8 | 6.1 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164223 | 88563 | 0 | None | -12 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 587 | 4 | 2 | 8 | 6.1 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | ||
| 54584420 | 67616 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 2.9 | CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762264 | 67616 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 2.9 | CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 54583451 | 67620 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762268 | 67620 | 0 | None | -1 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 25128865 | 89433 | 0 | None | -9 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 475 | 3 | 1 | 4 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179473 | 89433 | 0 | None | -9 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 475 | 3 | 1 | 4 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46887768 | 15358 | 0 | None | 11 | 2 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.3 | CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094772 | 15358 | 0 | None | 11 | 2 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 376 | 3 | 2 | 5 | 3.3 | CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1 | 10.1016/j.bmcl.2010.03.065 | ||
| 1214469 | 67599 | 1 | None | 5 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762245 | 67599 | 1 | None | 5 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46881559 | 13763 | 0 | None | -10 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 418 | 7 | 2 | 2 | 5.4 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1084696 | 13763 | 0 | None | -10 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 418 | 7 | 2 | 2 | 5.4 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46882061 | 13122 | 0 | None | 5 | 2 | Mouse | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 368 | 6 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1082041 | 13122 | 0 | None | 5 | 2 | Mouse | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 368 | 6 | 2 | 2 | 5.2 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 71451991 | 89561 | 0 | None | 15 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 477 | 2 | 2 | 5 | 5.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | 10.1021/ml200207w | ||
| CHEMBL2179916 | 89561 | 0 | None | 15 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 477 | 2 | 2 | 5 | 5.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | 10.1021/ml200207w | ||
| 46881602 | 15847 | 0 | None | -15 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 402 | 7 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1099033 | 15847 | 0 | None | -15 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 402 | 7 | 2 | 2 | 6.1 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46884662 | 14594 | 0 | None | -6 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089522 | 14594 | 0 | None | -6 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884687 | 14944 | 0 | None | -3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091917 | 14944 | 0 | None | -3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707365 | 88652 | 0 | None | -11 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| CHEMBL2164582 | 88652 | 0 | None | -11 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| 46887826 | 15353 | 0 | None | 1 | 2 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 322 | 3 | 2 | 5 | 2.2 | CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1094728 | 15353 | 0 | None | 1 | 2 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 322 | 3 | 2 | 5 | 2.2 | CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2010.03.065 | ||
| 25025862 | 14593 | 0 | None | 2 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089521 | 14593 | 0 | None | 2 | 2 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46881471 | 13233 | 0 | None | 13 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1082543 | 13233 | 0 | None | 13 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 396 | 7 | 2 | 2 | 5.5 | Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 44300413 | 107502 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 538 | 9 | 6 | 4 | 3.0 | O=C(CC1NCCc2ccccc21)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| CHEMBL292646 | 107502 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 538 | 9 | 6 | 4 | 3.0 | O=C(CC1NCCc2ccccc21)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 | 10.1021/jm0210921 | ||
| 46881510 | 14386 | 0 | None | 18 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1088062 | 14386 | 0 | None | 18 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 400 | 7 | 2 | 2 | 5.3 | O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46845425 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 8504 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089721 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 46845425 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | ||
| 8504 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | ||
| CHEMBL1089721 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | ||
| 46845425 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.01.154 | ||
| 8504 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1089721 | 7819 | 2 | None | -1 | 2 | Mouse | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.01.154 | ||
| 46885313 | 14874 | 0 | None | 3 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091554 | 14874 | 0 | None | 3 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 54586335 | 67608 | 0 | None | 12 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762254 | 67608 | 0 | None | 12 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | ||
| 46884627 | 15149 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093170 | 15149 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884663 | 14595 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089523 | 14595 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618753 | 88651 | 0 | None | -14 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 559 | 4 | 2 | 8 | 5.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | 10.1021/ml200304j | ||
| CHEMBL2164581 | 88651 | 0 | None | -14 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 559 | 4 | 2 | 8 | 5.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | 10.1021/ml200304j | ||
| 46881961 | 12603 | 0 | None | 28 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 348 | 8 | 2 | 2 | 4.9 | CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| CHEMBL1079114 | 12603 | 0 | None | 28 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 348 | 8 | 2 | 2 | 4.9 | CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | ||
| 46845425 | 7819 | 2 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 8504 | 7819 | 2 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1089721 | 7819 | 2 | None | -1 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 11891917 | 67600 | 1 | None | -8 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762246 | 67600 | 1 | None | -8 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 46885312 | 14873 | 0 | None | -10 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091553 | 14873 | 0 | None | -10 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884578 | 14952 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091984 | 14952 | 0 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884629 | 15151 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093183 | 15151 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25134006 | 88565 | 0 | None | -11 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 599 | 4 | 2 | 8 | 5.8 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| CHEMBL2164225 | 88565 | 0 | None | -11 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 599 | 4 | 2 | 8 | 5.8 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| 46885311 | 15087 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092730 | 15087 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 59618658 | 89441 | 0 | None | -2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179481 | 89441 | 0 | None | -2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | ||
| 46887765 | 15429 | 0 | None | 10 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 348 | 3 | 2 | 5 | 2.7 | Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1095424 | 15429 | 0 | None | 10 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 348 | 3 | 2 | 5 | 2.7 | Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 46884628 | 15025 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1092381 | 15025 | 0 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 25025861 | 15152 | 0 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1093184 | 15152 | 0 | None | 1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 56840673 | 7924 | 0 | None | 2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| 8503 | 7924 | 0 | None | 2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| CHEMBL2164575 | 7924 | 0 | None | 2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | ||
| 46885312 | 14873 | 0 | None | 10 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091553 | 14873 | 0 | None | 10 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884577 | 14884 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091599 | 14884 | 0 | None | 2 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884576 | 14883 | 0 | None | -4 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091598 | 14883 | 0 | None | -4 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | ||
| 46884577 | 14884 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091599 | 14884 | 0 | None | -2 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 11891917 | 67600 | 1 | None | 8 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| CHEMBL1762246 | 67600 | 1 | None | 8 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | ||
| 59618709 | 89552 | 1 | None | -14 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | 10.1021/ml200207w | ||
| CHEMBL2179908 | 89552 | 1 | None | -14 | 2 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | 10.1021/ml200207w | ||
| 25025860 | 7357 | 32 | None | -14 | 5 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 6188 | 7357 | 32 | None | -14 | 5 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091720 | 7357 | 32 | None | -14 | 5 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | ||
| 46884687 | 14944 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| CHEMBL1091917 | 14944 | 0 | None | 3 | 2 | Mouse | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | ||
| 62707207 | 88566 | 0 | None | -5 | 2 | Mouse | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 597 | 6 | 2 | 9 | 5.4 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| CHEMBL2164226 | 88566 | 0 | None | -5 | 2 | Mouse | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 597 | 6 | 2 | 9 | 5.4 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | ||
| 46887982 | 15516 | 0 | None | 47 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 4.1 | CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| CHEMBL1096193 | 15516 | 0 | None | 47 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 432 | 5 | 2 | 5 | 4.1 | CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3 | 10.1016/j.bmcl.2010.03.065 | ||
| 11261 | 7938 | 0 | None | -2 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Guide to Pharmacology | 428 | 4 | 1 | 3 | 5.0 | COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C | 28324017 | ||
| 154733031 | 7938 | 0 | None | -2 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Guide to Pharmacology | 428 | 4 | 1 | 3 | 5.0 | COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C | 28324017 | ||
| 11261 | 7938 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | Guide to Pharmacology | 428 | 4 | 1 | 3 | 5.0 | COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C | 28324017 | ||
| 154733031 | 7938 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | Guide to Pharmacology | 428 | 4 | 1 | 3 | 5.0 | COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C | 28324017 | ||
| 10569 | 9613 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | 31675498 | ||||
| 145996512 | 9613 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | 31675498 | ||||
| 6192 | 9871 | 0 | None | -3 | 3 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 19580790 | ||
| 73755184 | 9871 | 0 | None | -3 | 3 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 19580790 | ||
| 6191 | 7052 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 15635635 | ||||
| 6191 | 7052 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 18006692 | ||||
| 6191 | 7052 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 20438784 | ||||
| 6192 | 9871 | 0 | None | 3 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 19580790 | ||
| 73755184 | 9871 | 0 | None | 3 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 19580790 | ||
| 49871766 | 9335 | 40 | None | -17 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | ||
| 6170 | 9335 | 40 | None | -17 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | ||
| CHEMBL1672354 | 9335 | 40 | None | -17 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | ||
| 8508 | 7933 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | Guide to Pharmacology | 479 | 8 | 2 | 5 | 4.5 | CC(CCOc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 24412111 | ||
| 91827365 | 7933 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | Guide to Pharmacology | 479 | 8 | 2 | 5 | 4.5 | CC(CCOc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 24412111 | ||
| 8507 | 7789 | 0 | None | 3 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | Guide to Pharmacology | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 25497965 | ||
| 91827364 | 7789 | 0 | None | 3 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | Guide to Pharmacology | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 25497965 | ||
| CHEMBL3356404 | 7789 | 0 | None | 3 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | Guide to Pharmacology | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 25497965 | ||
| 6192 | 9871 | 0 | None | -4 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 12212809 | ||
| 6192 | 9871 | 0 | None | -4 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 19580790 | ||
| 73755184 | 9871 | 0 | None | -4 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 12212809 | ||
| 73755184 | 9871 | 0 | None | -4 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 19580790 | ||
| 72944991 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 24412111 | ||
| 72944991 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 26524625 | ||
| 72944991 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 35644465 | ||
| 8509 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 24412111 | ||
| 8509 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 26524625 | ||
| 8509 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 35644465 | ||
| CHEMBL3115390 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 24412111 | ||
| CHEMBL3115390 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 26524625 | ||
| CHEMBL3115390 | 7934 | 0 | None | 2 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 35644465 | ||
| 10254379 | 7813 | 0 | None | - | 1 | Human | 9.7 | pEC50 | None | 9.7 | Functional | Guide to Pharmacology | 475 | 9 | 5 | 3 | 4.4 | O=C(N[C@@H](C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NNc1ccc(cc1)Cl | 12723954 | ||
| 630 | 7813 | 0 | None | - | 1 | Human | 9.7 | pEC50 | None | 9.7 | Functional | Guide to Pharmacology | 475 | 9 | 5 | 3 | 4.4 | O=C(N[C@@H](C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NNc1ccc(cc1)Cl | 12723954 | ||
| 6192 | 9871 | 0 | None | -4 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 20438784 | ||
| 73755184 | 9871 | 0 | None | -4 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 482 | 10 | 4 | 3 | 3.4 | CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1 | 20438784 | ||
| 8505 | 9345 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 569 | 10 | 4 | 5 | 5.8 | COc1ccc(cc1)C1(CCCCC1)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)Nc1ccc(cc1)[N+](=O)[O-] | 25554218 | ||
| 91827363 | 9345 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 569 | 10 | 4 | 5 | 5.8 | COc1ccc(cc1)C1(CCCCC1)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)Nc1ccc(cc1)[N+](=O)[O-] | 25554218 | ||
| 6191 | 7052 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | None | None | None | None | 18006692 | ||||
| 6191 | 7052 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | None | None | None | None | 20438784 | ||||
| 25025654 | 7358 | 13 | None | -15 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 6189 | 7358 | 13 | None | -15 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 8506 | 7358 | 13 | None | -15 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| CHEMBL1084942 | 7358 | 13 | None | -15 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 49871766 | 9335 | 40 | None | -17 | 5 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 23892571 | ||
| 49871766 | 9335 | 40 | None | -17 | 5 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | ||
| 6170 | 9335 | 40 | None | -17 | 5 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 23892571 | ||
| 6170 | 9335 | 40 | None | -17 | 5 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | ||
| CHEMBL1672354 | 9335 | 40 | None | -17 | 5 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 23892571 | ||
| CHEMBL1672354 | 9335 | 40 | None | -17 | 5 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | ||
| 46845425 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 20167483 | ||
| 8504 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 20167483 | ||
| CHEMBL1089721 | 7819 | 2 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 20167483 | ||
| 25025860 | 7357 | 32 | None | -14 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| 6188 | 7357 | 32 | None | -14 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| CHEMBL1091720 | 7357 | 32 | None | -14 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| 633 | 8287 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | None | None | None | None | 18006692 | ||||
| 633 | 8287 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | None | None | None | None | 20438784 | ||||
| 25025654 | 7358 | 13 | None | -1 | 3 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 6189 | 7358 | 13 | None | -1 | 3 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 8506 | 7358 | 13 | None | -1 | 3 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| CHEMBL1084942 | 7358 | 13 | None | -1 | 3 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 6176 | 7361 | 0 | None | -4 | 5 | Mouse | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 20096642 | ||
| 73755180 | 7361 | 0 | None | -4 | 5 | Mouse | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 20096642 | ||
| 3946 | 8285 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 18006692 | ||||
| 3946 | 8285 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 20438784 | ||||
| 25025860 | 7357 | 32 | None | -4 | 5 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| 6188 | 7357 | 32 | None | -4 | 5 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| CHEMBL1091720 | 7357 | 32 | None | -4 | 5 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| 25025654 | 7358 | 13 | None | 1 | 3 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 6189 | 7358 | 13 | None | 1 | 3 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 8506 | 7358 | 13 | None | 1 | 3 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| CHEMBL1084942 | 7358 | 13 | None | 1 | 3 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | ||
| 46200989 | 9340 | 15 | None | 9 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 24900461 | ||
| 8502 | 9340 | 15 | None | 9 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 24900461 | ||
| CHEMBL2023109 | 9340 | 15 | None | 9 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 24900461 | ||
| 25025860 | 7357 | 32 | None | 4 | 5 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| 6188 | 7357 | 32 | None | 4 | 5 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| CHEMBL1091720 | 7357 | 32 | None | 4 | 5 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 20096642 | ||
| 6176 | 7361 | 0 | None | -1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 20096642 | ||
| 6176 | 7361 | 0 | None | -1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 23892571 | ||
| 6176 | 7361 | 0 | None | -1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 30971479 | ||
| 73755180 | 7361 | 0 | None | -1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 20096642 | ||
| 73755180 | 7361 | 0 | None | -1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 23892571 | ||
| 73755180 | 7361 | 0 | None | -1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 30971479 | ||
| 6176 | 7361 | 0 | None | 1 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 20096642 | ||
| 73755180 | 7361 | 0 | None | 1 | 5 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 895 | 23 | 7 | 8 | 4.8 | CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C | 20096642 | ||
| 56840673 | 7924 | 0 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 24900283 | ||
| 8503 | 7924 | 0 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 24900283 | ||
| CHEMBL2164575 | 7924 | 0 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 24900283 | ||
| 635 | 8232 | 0 | None | -6 | 4 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | None | None | None | None | 9325344 | ||||
| 635 | 8232 | 0 | None | -6 | 4 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | None | None | None | None | 9593699 | ||||
| 635 | 8232 | 0 | None | -6 | 4 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | None | None | None | None | 9765358 | ||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 155511392 | 176327 | 0 | None | - | 0 | Mouse | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 516 | 10 | 2 | 5 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4435571 | 176327 | 0 | None | - | 0 | Mouse | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 516 | 10 | 2 | 5 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155511392 | 176327 | 0 | None | - | 0 | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 516 | 10 | 2 | 5 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4435571 | 176327 | 0 | None | - | 0 | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 516 | 10 | 2 | 5 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155528415 | 178106 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 466 | 9 | 1 | 5 | 5.3 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4461212 | 178106 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 466 | 9 | 1 | 5 | 5.3 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76314247 | 112070 | 0 | None | - | 0 | Mouse | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115400 | 112070 | 0 | None | - | 0 | Mouse | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76314247 | 112070 | 0 | None | - | 0 | Mouse | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115400 | 112070 | 0 | None | - | 0 | Mouse | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| 76314247 | 112070 | 0 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115400 | 112070 | 0 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76314247 | 112070 | 0 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115400 | 112070 | 0 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| 46200989 | 9340 | 15 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmcl.2013.12.106 | |||
| 8502 | 9340 | 15 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL2023109 | 9340 | 15 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmcl.2013.12.106 | |||
| 76321532 | 112056 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115386 | 112056 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76321532 | 112056 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115386 | 112056 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 72944991 | 7934 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmcl.2013.12.106 | |||
| 8509 | 7934 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115390 | 7934 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmcl.2013.12.106 | |||
| 76328698 | 112058 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115388 | 112058 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 72944991 | 7934 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmc.2014.11.018 | |||
| 8509 | 7934 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115390 | 7934 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmc.2014.11.018 | |||
| 76328698 | 112058 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115388 | 112058 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76317821 | 112050 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 4.4 | O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115380 | 112050 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 4.4 | O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336000 | 112041 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115371 | 112041 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328696 | 112054 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 471 | 6 | 2 | 5 | 4.8 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115384 | 112054 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 471 | 6 | 2 | 5 | 4.8 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO | 10.1016/j.bmcl.2013.12.106 | |||
| 155521672 | 177429 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 452 | 9 | 2 | 4 | 5.2 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4451347 | 177429 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 452 | 9 | 2 | 4 | 5.2 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 155530555 | 178313 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4464287 | 178313 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76328696 | 112054 | 0 | None | - | 0 | Mouse | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 471 | 6 | 2 | 5 | 4.8 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115384 | 112054 | 0 | None | - | 0 | Mouse | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 471 | 6 | 2 | 5 | 4.8 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO | 10.1016/j.bmcl.2013.12.106 | |||
| 76325133 | 112052 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 457 | 5 | 2 | 5 | 4.4 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115382 | 112052 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 457 | 5 | 2 | 5 | 4.4 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO | 10.1016/j.bmcl.2013.12.106 | |||
| 8507 | 7789 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 10.1016/j.bmc.2014.11.018 | |||
| 91827364 | 7789 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356404 | 7789 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 10.1016/j.bmc.2014.11.018 | |||
| 155543657 | 179982 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 4 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4522752 | 179982 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 4 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76325135 | 112064 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115395 | 112064 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325135 | 112064 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115395 | 112064 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| 76332372 | 112045 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 379 | 4 | 1 | 4 | 3.5 | CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115375 | 112045 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 379 | 4 | 1 | 4 | 3.5 | CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336002 | 112049 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115379 | 112049 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336002 | 112049 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115379 | 112049 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155568183 | 182822 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 420 | 8 | 2 | 4 | 4.7 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4590481 | 182822 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 420 | 8 | 2 | 4 | 4.7 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 76328697 | 112055 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115385 | 112055 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328697 | 112055 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115385 | 112055 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155554592 | 181402 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 530 | 10 | 1 | 6 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4557722 | 181402 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 530 | 10 | 1 | 6 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155543657 | 179982 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 4 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4522752 | 179982 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 4 | 6.5 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 46200989 | 9340 | 15 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 8502 | 9340 | 15 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL2023109 | 9340 | 15 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 76332370 | 112039 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115369 | 112039 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76332370 | 112039 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115369 | 112039 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76336003 | 112065 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 428 | 3 | 2 | 4 | 5.4 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115396 | 112065 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 428 | 3 | 2 | 4 | 5.4 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 49871766 | 9335 | 40 | None | -9 | 3 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 6170 | 9335 | 40 | None | -9 | 3 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL1672354 | 9335 | 40 | None | -9 | 3 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 155538227 | 179145 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 438 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4476111 | 179145 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 438 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 76328697 | 112055 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115385 | 112055 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328697 | 112055 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115385 | 112055 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76336000 | 112041 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115371 | 112041 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76321531 | 112053 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 5 | 4.5 | O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115383 | 112053 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 5 | 4.5 | O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325134 | 112059 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115389 | 112059 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325134 | 112059 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115389 | 112059 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76317820 | 112044 | 0 | None | - | 0 | Mouse | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 365 | 3 | 1 | 4 | 3.1 | COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115374 | 112044 | 0 | None | - | 0 | Mouse | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 365 | 3 | 1 | 4 | 3.1 | COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 118721523 | 122850 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.2 | CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356405 | 122850 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.2 | CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76325133 | 112052 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 457 | 5 | 2 | 5 | 4.4 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115382 | 112052 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 457 | 5 | 2 | 5 | 4.4 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO | 10.1016/j.bmcl.2013.12.106 | |||
| 155541223 | 179779 | 0 | None | - | 0 | Mouse | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4518142 | 179779 | 0 | None | - | 0 | Mouse | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76336002 | 112049 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115379 | 112049 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336002 | 112049 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115379 | 112049 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 4.5 | CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155519281 | 177218 | 0 | None | - | 0 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 501 | 10 | 2 | 5 | 4.3 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4448589 | 177218 | 0 | None | - | 0 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 501 | 10 | 2 | 5 | 4.3 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O | 10.1016/j.bmcl.2016.07.056 | |||
| 155561529 | 182409 | 0 | None | - | 0 | Mouse | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 424 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4580739 | 182409 | 0 | None | - | 0 | Mouse | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 424 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO | 10.1016/j.bmcl.2016.07.056 | |||
| 76328698 | 112058 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115388 | 112058 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336005 | 112068 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115399 | 112068 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328698 | 112058 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115388 | 112058 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76336005 | 112068 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115399 | 112068 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| 76325132 | 112043 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115373 | 112043 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325132 | 112043 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115373 | 112043 | 0 | None | - | 0 | Mouse | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721525 | 122852 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.5 | CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356407 | 122852 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.5 | CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76317820 | 112044 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 365 | 3 | 1 | 4 | 3.1 | COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115374 | 112044 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 365 | 3 | 1 | 4 | 3.1 | COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76332372 | 112045 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 379 | 4 | 1 | 4 | 3.5 | CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115375 | 112045 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 379 | 4 | 1 | 4 | 3.5 | CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76332373 | 112057 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115387 | 112057 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76332373 | 112057 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115387 | 112057 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155539847 | 179261 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 438 | 8 | 1 | 5 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4482945 | 179261 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 438 | 8 | 1 | 5 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 49871766 | 9335 | 40 | None | -2 | 3 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 6170 | 9335 | 40 | None | -2 | 3 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL1672354 | 9335 | 40 | None | -2 | 3 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 46200989 | 9340 | 15 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmcl.2013.12.106 | |||
| 8502 | 9340 | 15 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL2023109 | 9340 | 15 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmcl.2013.12.106 | |||
| 155519753 | 177221 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.2 | COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4448645 | 177221 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.2 | COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76321531 | 112053 | 0 | None | - | 0 | Mouse | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 471 | 5 | 2 | 5 | 4.5 | O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115383 | 112053 | 0 | None | - | 0 | Mouse | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 471 | 5 | 2 | 5 | 4.5 | O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76317822 | 112061 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115392 | 112061 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76317822 | 112061 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115392 | 112061 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| 155539847 | 179261 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 438 | 8 | 1 | 5 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4482945 | 179261 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 438 | 8 | 1 | 5 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76317823 | 112071 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115401 | 112071 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76310619 | 112063 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115394 | 112063 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmcl.2013.12.106 | |||
| 76310619 | 112063 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115394 | 112063 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmc.2014.11.018 | |||
| 155554592 | 181402 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 530 | 10 | 1 | 6 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4557722 | 181402 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 530 | 10 | 1 | 6 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76317823 | 112071 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115401 | 112071 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328694 | 112040 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115370 | 112040 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| 76328694 | 112040 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115370 | 112040 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmc.2014.11.018 | |||
| 155520679 | 177275 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4449347 | 177275 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 118721522 | 122849 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356403 | 122849 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155561529 | 182409 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 424 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4580739 | 182409 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 424 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO | 10.1016/j.bmcl.2016.07.056 | |||
| 155568881 | 182961 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4593256 | 182961 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155528415 | 178106 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 466 | 9 | 1 | 5 | 5.3 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4461212 | 178106 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 466 | 9 | 1 | 5 | 5.3 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 118721530 | 122856 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.7 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356412 | 122856 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.7 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76321532 | 112056 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115386 | 112056 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76321532 | 112056 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115386 | 112056 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 72944991 | 7934 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmcl.2013.12.106 | |||
| 8509 | 7934 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115390 | 7934 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmcl.2013.12.106 | |||
| 76328699 | 112066 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115397 | 112066 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 72944991 | 7934 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmc.2014.11.018 | |||
| 8509 | 7934 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115390 | 7934 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 4.6 | OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C | 10.1016/j.bmc.2014.11.018 | |||
| 76336005 | 112068 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115399 | 112068 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336005 | 112068 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115399 | 112068 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721530 | 122856 | 0 | None | - | 0 | Mouse | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.7 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356412 | 122856 | 0 | None | - | 0 | Mouse | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.7 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76332373 | 112057 | 0 | None | - | 0 | Mouse | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115387 | 112057 | 0 | None | - | 0 | Mouse | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76332373 | 112057 | 0 | None | - | 0 | Mouse | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115387 | 112057 | 0 | None | - | 0 | Mouse | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.9 | O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 56840673 | 7924 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| 8503 | 7924 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL2164575 | 7924 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| 56840673 | 7924 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmc.2014.11.018 | |||
| 8503 | 7924 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL2164575 | 7924 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmc.2014.11.018 | |||
| 76332370 | 112039 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115369 | 112039 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76332370 | 112039 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115369 | 112039 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 484 | 5 | 1 | 4 | 5.6 | CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721523 | 122850 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.2 | CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356405 | 122850 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.2 | CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76314246 | 112062 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115393 | 112062 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmcl.2013.12.106 | |||
| 76314246 | 112062 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115393 | 112062 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmc.2014.11.018 | |||
| 76328695 | 112046 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115376 | 112046 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328695 | 112046 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115376 | 112046 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 132538074 | 179609 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 4.9 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4514194 | 179609 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 4.9 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 118721529 | 122855 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.1 | CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356411 | 122855 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.1 | CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155519281 | 177218 | 0 | None | - | 0 | Mouse | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 501 | 10 | 2 | 5 | 4.3 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4448589 | 177218 | 0 | None | - | 0 | Mouse | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 501 | 10 | 2 | 5 | 4.3 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O | 10.1016/j.bmcl.2016.07.056 | |||
| 118721528 | 122854 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 3.9 | CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356410 | 122854 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 3.9 | CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721527 | 122853 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356409 | 122853 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155541223 | 179779 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4518142 | 179779 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76317821 | 112050 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 4.4 | O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115380 | 112050 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 4.4 | O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 118721524 | 122851 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.8 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356406 | 122851 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.8 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155520679 | 177275 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4449347 | 177275 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 391 | 9 | 1 | 4 | 4.8 | CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 8507 | 7789 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 10.1016/j.bmc.2014.11.018 | |||
| 91827364 | 7789 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356404 | 7789 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.1 | CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C | 10.1016/j.bmc.2014.11.018 | |||
| 76336003 | 112065 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 428 | 3 | 2 | 4 | 5.4 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115396 | 112065 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 428 | 3 | 2 | 4 | 5.4 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 132538074 | 179609 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 4.9 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4514194 | 179609 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 4.9 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 118721527 | 122853 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356409 | 122853 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76310619 | 112063 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115394 | 112063 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmcl.2013.12.106 | |||
| 76310619 | 112063 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115394 | 112063 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 475 | 4 | 1 | 4 | 6.7 | O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21 | 10.1016/j.bmc.2014.11.018 | |||
| 76317822 | 112061 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115392 | 112061 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76317822 | 112061 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115392 | 112061 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 439 | 2 | 1 | 3 | 6.2 | CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1016/j.bmc.2014.11.018 | |||
| 155552947 | 180860 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 5.2 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4544477 | 180860 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 5.2 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155568881 | 182961 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4593256 | 182961 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.6 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 118721528 | 122854 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 3.9 | CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356410 | 122854 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 3.9 | CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721531 | 122857 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.3 | CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356413 | 122857 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.3 | CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721529 | 122855 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.1 | CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356411 | 122855 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.1 | CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76336001 | 112047 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115377 | 112047 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336001 | 112047 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115377 | 112047 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76328695 | 112046 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115376 | 112046 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328695 | 112046 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115376 | 112046 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 393 | 4 | 1 | 4 | 3.9 | CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76336001 | 112047 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115377 | 112047 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336001 | 112047 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115377 | 112047 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 4.3 | CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76336004 | 112067 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115398 | 112067 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76328699 | 112066 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115397 | 112066 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 155521672 | 177429 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 452 | 9 | 2 | 4 | 5.2 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4451347 | 177429 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 452 | 9 | 2 | 4 | 5.2 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 76310617 | 112048 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115378 | 112048 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325134 | 112059 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115389 | 112059 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76310617 | 112048 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115378 | 112048 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76325134 | 112059 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115389 | 112059 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76332371 | 112042 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115372 | 112042 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 155515849 | 176779 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 358 | 7 | 1 | 4 | 4.1 | COC(=O)C(C)(C)Oc1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4442362 | 176779 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 358 | 7 | 1 | 4 | 4.1 | COC(=O)C(C)(C)Oc1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155552947 | 180860 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 5.2 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4544477 | 180860 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 5.2 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 118721522 | 122849 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356403 | 122849 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 479 | 6 | 2 | 6 | 3.7 | CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155538227 | 179145 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 438 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4476111 | 179145 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 438 | 8 | 2 | 4 | 4.8 | CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 155543793 | 179994 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.8 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4522974 | 179994 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.8 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 155530555 | 178313 | 0 | None | - | 0 | Mouse | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4464287 | 178313 | 0 | None | - | 0 | Mouse | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 76310617 | 112048 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115378 | 112048 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76310617 | 112048 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115378 | 112048 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 4.1 | CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 46200989 | 9340 | 15 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 8502 | 9340 | 15 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL2023109 | 9340 | 15 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2014.11.018 | |||
| 76314245 | 112051 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 4.8 | O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115381 | 112051 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 4.8 | O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 118721531 | 122857 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.3 | CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356413 | 122857 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.3 | CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76325135 | 112064 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115395 | 112064 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325135 | 112064 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115395 | 112064 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 4.9 | O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmc.2014.11.018 | |||
| 118721525 | 122852 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.5 | CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356407 | 122852 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 507 | 6 | 2 | 6 | 4.5 | CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 76314245 | 112051 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 4.8 | O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115381 | 112051 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 4.8 | O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76336004 | 112067 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115398 | 112067 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 445 | 4 | 1 | 4 | 5.0 | O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 118721524 | 122851 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.8 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3356406 | 122851 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 491 | 7 | 2 | 6 | 3.8 | O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1 | 10.1016/j.bmc.2014.11.018 | |||
| 155568183 | 182822 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 420 | 8 | 2 | 4 | 4.7 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4590481 | 182822 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 420 | 8 | 2 | 4 | 4.7 | CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O | 10.1016/j.bmcl.2016.07.056 | |||
| 76325132 | 112043 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115373 | 112043 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmcl.2013.12.106 | |||
| 76325132 | 112043 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115373 | 112043 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 442 | 4 | 1 | 5 | 4.6 | Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1 | 10.1016/j.bmc.2014.11.018 | |||
| 76328694 | 112040 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115370 | 112040 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| 76328694 | 112040 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL3115370 | 112040 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 322 | 3 | 0 | 2 | 4.1 | CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C | 10.1016/j.bmc.2014.11.018 | |||
| 155543793 | 179994 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.8 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4522974 | 179994 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.8 | COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 56840673 | 7924 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| 8503 | 7924 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL2164575 | 7924 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2013.12.106 | |||
| 56840673 | 7924 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmc.2014.11.018 | |||
| 8503 | 7924 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmc.2014.11.018 | |||
| CHEMBL2164575 | 7924 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmc.2014.11.018 | |||
| 76332371 | 112042 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| CHEMBL3115372 | 112042 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 428 | 4 | 1 | 5 | 4.3 | O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1 | 10.1016/j.bmcl.2013.12.106 | |||
| 155519753 | 177221 | 0 | None | - | 0 | Mouse | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.2 | COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| CHEMBL4448645 | 177221 | 0 | None | - | 0 | Mouse | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.2 | COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1 | 10.1016/j.bmcl.2016.07.056 | |||
| 25129212 | 80967 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 574 | 5 | 2 | 6 | 5.2 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1016/j.bmc.2012.03.029 | |||
| CHEMBL2023112 | 80967 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 574 | 5 | 2 | 6 | 5.2 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1016/j.bmc.2012.03.029 | |||
| 59618746 | 80968 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 586 | 5 | 2 | 6 | 5.4 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | |||
| CHEMBL2023113 | 80968 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 586 | 5 | 2 | 6 | 5.4 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | |||
| 25128867 | 80966 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 669 | 6 | 2 | 9 | 6.5 | CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1 | 10.1016/j.bmc.2012.03.029 | |||
| CHEMBL2023111 | 80966 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 669 | 6 | 2 | 9 | 6.5 | CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1 | 10.1016/j.bmc.2012.03.029 | |||
| 59618681 | 89563 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 512 | 2 | 1 | 5 | 6.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | 10.1021/ml200207w | |||
| CHEMBL2179918 | 89563 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 512 | 2 | 1 | 5 | 6.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | 10.1021/ml200207w | |||
| 59618753 | 88651 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 4 | 2 | 8 | 5.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164581 | 88651 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 4 | 2 | 8 | 5.4 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | 10.1021/ml200304j | |||
| 62707362 | 88647 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 541 | 3 | 1 | 6 | 6.3 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | 10.1021/ml200304j | |||
| CHEMBL2164577 | 88647 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 541 | 3 | 1 | 6 | 6.3 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | 10.1021/ml200304j | |||
| 66901749 | 89556 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179911 | 89556 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 59618790 | 88563 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 4 | 2 | 8 | 6.1 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164223 | 88563 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 4 | 2 | 8 | 6.1 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | |||
| 62707364 | 88650 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 529 | 3 | 1 | 7 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164580 | 88650 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 529 | 3 | 1 | 7 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL413893 | 219878 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O | 10.1021/jm049437y | |||||
| 59618709 | 89552 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179908 | 89552 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | 10.1021/ml200207w | |||
| 62707365 | 88652 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| CHEMBL2164582 | 88652 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| 49871766 | 9335 | 40 | None | 2 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 6170 | 9335 | 40 | None | 2 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| CHEMBL1672354 | 9335 | 40 | None | 2 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 59618821 | 80965 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 657 | 6 | 2 | 9 | 6.4 | CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1016/j.bmc.2012.03.029 | |||
| CHEMBL2023110 | 80965 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 657 | 6 | 2 | 9 | 6.4 | CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1016/j.bmc.2012.03.029 | |||
| 56840673 | 7924 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | |||
| 8503 | 7924 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | |||
| CHEMBL2164575 | 7924 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | |||
| 62707363 | 88648 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 3 | 2 | 5 | 6.3 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164578 | 88648 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 3 | 2 | 5 | 6.3 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | 10.1021/ml200304j | |||
| 25128865 | 89433 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 475 | 3 | 1 | 4 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179473 | 89433 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 475 | 3 | 1 | 4 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 25134007 | 88564 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 5 | 2 | 8 | 6.0 | CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164224 | 88564 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 5 | 2 | 8 | 6.0 | CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | 10.1021/ml200304j | |||
| 59618747 | 88646 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 538 | 3 | 1 | 5 | 6.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164576 | 88646 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 538 | 3 | 1 | 5 | 6.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | 10.1021/ml200304j | |||
| 62707528 | 88562 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| CHEMBL2164222 | 88562 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 4 | 2 | 8 | 6.0 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| 46889210 | 14304 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 387 | 6 | 2 | 2 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1087443 | 14304 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 387 | 6 | 2 | 2 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 59618785 | 89440 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179480 | 89440 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 59618635 | 89443 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 435 | 2 | 1 | 4 | 5.8 | Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2 | 10.1021/ml200207w | |||
| CHEMBL2179484 | 89443 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 435 | 2 | 1 | 4 | 5.8 | Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2 | 10.1021/ml200207w | |||
| 46884660 | 13214 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1082471 | 13214 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 53242205 | 67601 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762247 | 67601 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 46884578 | 14952 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091984 | 14952 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46889148 | 14457 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 406 | 10 | 2 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088686 | 14457 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 406 | 10 | 2 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 46845425 | 7819 | 2 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | |||
| 8504 | 7819 | 2 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1089721 | 7819 | 2 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.03.028 | |||
| 25026044 | 64616 | 1 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 390 | 6 | 2 | 4 | 3.9 | CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1 | 10.1021/ml100196d | |||
| CHEMBL1671874 | 64616 | 1 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 390 | 6 | 2 | 4 | 3.9 | CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1 | 10.1021/ml100196d | |||
| 46845425 | 7819 | 2 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 8504 | 7819 | 2 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1089721 | 7819 | 2 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 376 | 8 | 2 | 2 | 5.5 | CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 46884630 | 15192 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1093459 | 15192 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 339 | 7 | 1 | 3 | 5.3 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46889177 | 14256 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 497 | 10 | 2 | 4 | 6.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1087066 | 14256 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 497 | 10 | 2 | 4 | 6.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 59618658 | 89441 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179481 | 89441 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 507 | 2 | 1 | 5 | 6.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 46884629 | 15151 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1093183 | 15151 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 358 | 7 | 1 | 3 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46889145 | 15848 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 398 | 7 | 2 | 4 | 4.8 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1099034 | 15848 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 398 | 7 | 2 | 4 | 4.8 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1 | 10.1016/j.bmcl.2010.03.028 | |||
| 25025861 | 15152 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | |||
| CHEMBL1093184 | 15152 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | |||
| 56840673 | 7924 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | |||
| 8503 | 7924 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | |||
| CHEMBL2164575 | 7924 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 489 | 2 | 1 | 4 | 6.5 | Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1021/ml200207w | |||
| 25026445 | 64719 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | |||
| CHEMBL1672352 | 64719 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | |||
| 46884576 | 14883 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091598 | 14883 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 331 | 6 | 1 | 2 | 5.0 | c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1 | 10.1016/j.bmcl.2010.02.076 | |||
| 25026058 | 14441 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088553 | 14441 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 62707207 | 88566 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 597 | 6 | 2 | 9 | 5.4 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| CHEMBL2164226 | 88566 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 597 | 6 | 2 | 9 | 5.4 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| 25025860 | 7357 | 32 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 6188 | 7357 | 32 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091720 | 7357 | 32 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 25025861 | 15152 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1093184 | 15152 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 59618711 | 80969 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 600 | 5 | 2 | 6 | 5.6 | CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | |||
| CHEMBL2023114 | 80969 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 600 | 5 | 2 | 6 | 5.6 | CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | 10.1016/j.bmc.2012.03.029 | |||
| 71451991 | 89561 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 477 | 2 | 2 | 5 | 5.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | 10.1021/ml200207w | |||
| CHEMBL2179916 | 89561 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 477 | 2 | 2 | 5 | 5.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | 10.1021/ml200207w | |||
| 25025860 | 7357 | 32 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 6188 | 7357 | 32 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091720 | 7357 | 32 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 46889232 | 14285 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 401 | 6 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1087200 | 14285 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 401 | 6 | 1 | 2 | 5.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 59618675 | 89439 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 497 | 1 | 1 | 5 | 4.8 | Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179479 | 89439 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 497 | 1 | 1 | 5 | 4.8 | Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 46884687 | 14944 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091917 | 14944 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 324 | 7 | 1 | 5 | 3.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46889175 | 14213 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1086673 | 14213 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 54581470 | 67602 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762248 | 67602 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54583453 | 67623 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 389 | 5 | 3 | 5 | 3.5 | CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762271 | 67623 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 389 | 5 | 3 | 5 | 3.5 | CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1 | 10.1016/j.bmcl.2011.02.011 | |||
| 54582477 | 67622 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 406 | 5 | 2 | 6 | 4.2 | CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762270 | 67622 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 406 | 5 | 2 | 6 | 4.2 | CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | |||
| 46889235 | 14431 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088411 | 14431 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.0 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 46889176 | 14214 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 444 | 10 | 3 | 5 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1086674 | 14214 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 444 | 10 | 3 | 5 | 5.1 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 49871766 | 9335 | 40 | None | -9 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 6170 | 9335 | 40 | None | -9 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| CHEMBL1672354 | 9335 | 40 | None | -9 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 46884688 | 14945 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091918 | 14945 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 339 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46885313 | 14874 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091554 | 14874 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46889147 | 14456 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 7 | 1 | 5 | 5.7 | O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088685 | 14456 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 7 | 1 | 5 | 5.7 | O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1 | 10.1016/j.bmcl.2010.03.028 | |||
| 136118727 | 88649 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 545 | 3 | 2 | 7 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1 | 10.1021/ml200304j | |||
| CHEMBL2164579 | 88649 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 545 | 3 | 2 | 7 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1 | 10.1021/ml200304j | |||
| 54583454 | 67625 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762273 | 67625 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 66901760 | 89557 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 495 | 2 | 1 | 4 | 6.5 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | 10.1021/ml200207w | |||
| CHEMBL2179912 | 89557 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 495 | 2 | 1 | 4 | 6.5 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | 10.1021/ml200207w | |||
| 59618698 | 89436 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 517 | 3 | 1 | 5 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179476 | 89436 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 517 | 3 | 1 | 5 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 46200989 | 9340 | 15 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | |||
| 8502 | 9340 | 15 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | |||
| CHEMBL2023109 | 9340 | 15 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1016/j.bmc.2012.03.029 | |||
| 46200989 | 9340 | 15 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1021/ml200304j | |||
| 8502 | 9340 | 15 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1021/ml200304j | |||
| CHEMBL2023109 | 9340 | 15 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 5 | 2 | 9 | 5.7 | FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F | 10.1021/ml200304j | |||
| 54580463 | 67609 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762255 | 67609 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | |||
| 54580465 | 67611 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 390 | 5 | 3 | 5 | 3.2 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762258 | 67611 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 390 | 5 | 3 | 5 | 3.2 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1 | 10.1016/j.bmcl.2011.02.011 | |||
| 136086809 | 14215 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 445 | 10 | 3 | 4 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1086684 | 14215 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 445 | 10 | 3 | 4 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 46889146 | 14455 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 348 | 7 | 2 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088684 | 14455 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 348 | 7 | 2 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 54581471 | 67606 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 5 | 3 | 5 | 3.6 | O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762252 | 67606 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 5 | 3 | 5 | 3.6 | O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54582478 | 67626 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762274 | 67626 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 25025862 | 14593 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1089521 | 14593 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 322 | 7 | 1 | 3 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46884662 | 14594 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1089522 | 14594 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46885311 | 15087 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1092730 | 15087 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 424 | 7 | 2 | 2 | 6.0 | O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46882011 | 12663 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | |||
| CHEMBL1079517 | 12663 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 406 | 11 | 3 | 3 | 5.2 | CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1 | 10.1016/j.bmcl.2010.01.154 | |||
| 11389266 | 168584 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1303 | 44 | 17 | 18 | -2.7 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O | 10.1021/jm049437y | |||
| CHEMBL414307 | 168584 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1303 | 44 | 17 | 18 | -2.7 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O | 10.1021/jm049437y | |||
| 54583450 | 67612 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 388 | 4 | 3 | 5 | 3.0 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762259 | 67612 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 388 | 4 | 3 | 5 | 3.0 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21 | 10.1016/j.bmcl.2011.02.011 | |||
| 46884663 | 14595 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1089523 | 14595 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 323 | 7 | 1 | 4 | 3.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 59618678 | 89551 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 446 | 2 | 1 | 5 | 5.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179907 | 89551 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 446 | 2 | 1 | 5 | 5.3 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | 10.1021/ml200207w | |||
| 59618646 | 89442 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 421 | 2 | 1 | 4 | 5.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179482 | 89442 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 421 | 2 | 1 | 4 | 5.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2 | 10.1021/ml200207w | |||
| 54587369 | 67607 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 4 | 3 | 5 | 2.6 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762253 | 67607 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 4 | 3 | 5 | 2.6 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1 | 10.1016/j.bmcl.2011.02.011 | |||
| 71462686 | 89553 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(Cl)cnc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179909 | 89553 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 455 | 2 | 1 | 4 | 6.1 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(Cl)cnc1N2 | 10.1021/ml200207w | |||
| 46884659 | 14589 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1089511 | 14589 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 340 | 7 | 1 | 4 | 4.7 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 25026446 | 64720 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 338 | 5 | 2 | 4 | 3.6 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1 | 10.1021/ml100196d | |||
| CHEMBL1672353 | 64720 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 338 | 5 | 2 | 4 | 3.6 | CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1 | 10.1021/ml100196d | |||
| 71451990 | 89560 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 537 | 3 | 2 | 5 | 6.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | 10.1021/ml200207w | |||
| CHEMBL2179915 | 89560 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 537 | 3 | 2 | 5 | 6.2 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | 10.1021/ml200207w | |||
| 46889233 | 14429 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 8 | 2 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088409 | 14429 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 8 | 2 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 25025863 | 15271 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 430 | 10 | 2 | 5 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1094054 | 15271 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 430 | 10 | 2 | 5 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 59618620 | 89562 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 2 | 1 | 5 | 5.6 | Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179917 | 89562 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 2 | 1 | 5 | 5.6 | Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 49871766 | 9335 | 40 | None | -2 | 3 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 6170 | 9335 | 40 | None | -2 | 3 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| CHEMBL1672354 | 9335 | 40 | None | -2 | 3 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 59618811 | 89559 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 461 | 2 | 1 | 4 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1021/ml200207w | |||
| CHEMBL2179914 | 89559 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 461 | 2 | 1 | 4 | 5.9 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1 | 10.1021/ml200207w | |||
| 71460937 | 89437 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 493 | 3 | 1 | 4 | 6.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179477 | 89437 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 493 | 3 | 1 | 4 | 6.4 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 59618730 | 89438 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 3 | 1 | 5 | 6.0 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179478 | 89438 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 3 | 1 | 5 | 6.0 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 71460964 | 89558 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179913 | 89558 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 475 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 46884661 | 14590 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1089512 | 14590 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 334 | 7 | 1 | 3 | 4.6 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46884627 | 15149 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1093170 | 15149 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 349 | 7 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 1214469 | 67599 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762245 | 67599 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54583452 | 67621 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 4.8 | CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762269 | 67621 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 4.8 | CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1 | 10.1016/j.bmcl.2011.02.011 | |||
| 54580462 | 67605 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 422 | 6 | 3 | 5 | 3.9 | CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762251 | 67605 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 422 | 6 | 3 | 5 | 3.9 | CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 46885312 | 14873 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091553 | 14873 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 4.9 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46861857 | 14212 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 10 | 3 | 4 | 6.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1086672 | 14212 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 10 | 3 | 4 | 6.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 46889234 | 14430 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 407 | 8 | 2 | 5 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1088410 | 14430 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 407 | 8 | 2 | 5 | 4.4 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 25026056 | 14953 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091985 | 14953 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 347 | 7 | 1 | 2 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 59618623 | 89434 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 501 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179474 | 89434 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 501 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 25025860 | 7357 | 32 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 6188 | 7357 | 32 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091720 | 7357 | 32 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C | 10.1016/j.bmcl.2010.02.076 | |||
| 4157547 | 32001 | 9 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1348293 | 32001 | 9 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54581472 | 67615 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 365 | 4 | 3 | 4 | 3.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762263 | 67615 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 365 | 4 | 3 | 4 | 3.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54584418 | 67603 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762249 | 67603 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54585380 | 67618 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762266 | 67618 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C | 10.1016/j.bmcl.2011.02.011 | |||
| 54586335 | 67608 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762254 | 67608 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 408 | 4 | 3 | 5 | 3.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C | 10.1016/j.bmcl.2011.02.011 | |||
| 54583451 | 67620 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762268 | 67620 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 380 | 4 | 2 | 5 | 2.8 | CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 53242205 | 67601 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762247 | 67601 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 366 | 4 | 3 | 5 | 2.5 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54582478 | 67626 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762274 | 67626 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 388 | 6 | 3 | 6 | 2.9 | O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 46884628 | 15025 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1092381 | 15025 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 348 | 7 | 2 | 3 | 4.8 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 46884577 | 14884 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| CHEMBL1091599 | 14884 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 333 | 7 | 1 | 2 | 5.2 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1 | 10.1016/j.bmcl.2010.02.076 | |||
| 59618778 | 89435 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 511 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179475 | 89435 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 511 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2 | 10.1021/ml200207w | |||
| 54580461 | 67604 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 380 | 6 | 3 | 5 | 2.9 | CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762250 | 67604 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 380 | 6 | 3 | 5 | 2.9 | CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54581474 | 67624 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 376 | 6 | 3 | 6 | 2.7 | CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762272 | 67624 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 376 | 6 | 3 | 6 | 2.7 | CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1 | 10.1016/j.bmcl.2011.02.011 | |||
| 25134006 | 88565 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 4 | 2 | 8 | 5.8 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| CHEMBL2164225 | 88565 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 4 | 2 | 8 | 5.8 | CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | 10.1021/ml200304j | |||
| 59618710 | 89555 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 473 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2 | 10.1021/ml200207w | |||
| CHEMBL2179910 | 89555 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 473 | 2 | 1 | 4 | 6.2 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2 | 10.1021/ml200207w | |||
| 25055504 | 64718 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | |||
| CHEMBL1672351 | 64718 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 367 | 5 | 2 | 3 | 4.7 | CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1 | 10.1021/ml100196d | |||
| 11891917 | 67600 | 1 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762246 | 67600 | 1 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 352 | 5 | 3 | 5 | 2.1 | CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 46889209 | 14303 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| CHEMBL1087442 | 14303 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 429 | 10 | 2 | 4 | 5.5 | CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1 | 10.1016/j.bmcl.2010.03.028 | |||
| 54586337 | 67614 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762262 | 67614 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54581473 | 67619 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 365 | 4 | 4 | 5 | 2.3 | CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762267 | 67619 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 365 | 4 | 4 | 5 | 2.3 | CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| 54585379 | 67613 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL1762261 | 67613 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 367 | 4 | 2 | 5 | 2.4 | CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2 | 10.1016/j.bmcl.2011.02.011 | |||
| CHEMBL525577 | 222432 | 0 | None | 2 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O | 10.1016/j.bmcl.2008.09.033 | |||||
| 49871766 | 9335 | 40 | None | 2 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 6170 | 9335 | 40 | None | 2 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| CHEMBL1672354 | 9335 | 40 | None | 2 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 49871766 | 9335 | 40 | None | -2 | 3 | Mouse | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 6170 | 9335 | 40 | None | -2 | 3 | Mouse | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| CHEMBL1672354 | 9335 | 40 | None | -2 | 3 | Mouse | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 49871766 | 9335 | 40 | None | -9 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 6170 | 9335 | 40 | None | -9 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| CHEMBL1672354 | 9335 | 40 | None | -9 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 10.1021/ml100196d | |||
| 71300326 | 125279 | 40 | None | -6 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 499 | 6 | 2 | 4 | 3.0 | O=C([C@@H](Cc1cccc(C(F)(F)F)c1)NS(=O)(=O)c1cc(F)c2c(c1)CCNC2)N1CCCC1 | 10.6019/CHEMBL5212743 | |||
| CHEMBL3414622 | 125279 | 40 | None | -6 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 499 | 6 | 2 | 4 | 3.0 | O=C([C@@H](Cc1cccc(C(F)(F)F)c1)NS(=O)(=O)c1cc(F)c2c(c1)CCNC2)N1CCCC1 | 10.6019/CHEMBL5212743 | |||
| CHEMBL4789678 | 125279 | 40 | None | -6 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 499 | 6 | 2 | 4 | 3.0 | O=C([C@@H](Cc1cccc(C(F)(F)F)c1)NS(=O)(=O)c1cc(F)c2c(c1)CCNC2)N1CCCC1 | 10.6019/CHEMBL5212743 | |||
| 25025654 | 7358 | 13 | None | - | 1 | Mouse | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | |||
| 6189 | 7358 | 13 | None | - | 1 | Mouse | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | |||
| 8506 | 7358 | 13 | None | - | 1 | Mouse | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | |||
| CHEMBL1084942 | 7358 | 13 | None | - | 1 | Mouse | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 374 | 7 | 2 | 2 | 5.3 | OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1 | 20096642 | |||
| 164512405 | 222728 | 0 | 125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14) | -316 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
| None | 222866 | 0 | 125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 1054 | 32 | 14 | 14 | -3.4 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)N | None | |||
| None | 222866 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 1054 | 32 | 14 | 14 | -3.4 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)N | None | |||
| 23185015 | 222867 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 2858 | 85 | 36 | 38 | -8.6 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CNC=N1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CNC=N4)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C5CCCN5C(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)O)NC(=O)CNC(=O)CNC(=O)CNC(=O)C(C)NC(=O)C7CCCN7C(=O)C(CC(C)C)NC(=O)C8CCCN8C(=O)C(C(C)C)N | None | |||
| None | 222872 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 1120 | 33 | 15 | 15 | -3.6 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CN=CN4)NC(=O)C(CC(=O)N)NC(=O)CN | None | |||
| None | 222870 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 1019 | 28 | 12 | 12 | -1.3 | CC(C)CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCSC)C(=O)N)NC(=O)C4CCC(=O)N4 | None | |||
| None | 222871 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 1071 | 29 | 13 | 13 | -1.6 | CCC(C)C(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCSC)C(=O)N)NC(=O)C5CCC(=O)N5 | None | |||
| 25078137 | 222869 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 1535 | 47 | 21 | 20 | -6.1 | C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H]4CCC(=O)N4)O | None | |||
| None | 222868 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 1084 | 30 | 13 | 13 | -2.1 | CC(C)C(C(=O)NCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCSC)C(=O)N)NC(=O)C(C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5 | None | |||
| 164512405 | 222728 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | -316 | 12 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
| 164512399 | 222874 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 304 | 7 | 4 | 9 | -10.5 | C(C(C(C(C(=O)COP(=O)([O-])[O-])O)O)O)O.[Na+].[Na+] | None | |||
| 22146595 | 10063 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | -3467 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 618 | 10063 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | -3467 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| None | 222873 | 0 | 125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14) | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 49871766 | 9335 | 40 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 23892571 | |||
| 49871766 | 9335 | 40 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | |||
| 6170 | 9335 | 40 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 23892571 | |||
| 6170 | 9335 | 40 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | |||
| CHEMBL1672354 | 9335 | 40 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 23892571 | |||
| CHEMBL1672354 | 9335 | 40 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 24900253 | |||
| 3946 | 8285 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 15102928 | |||||
| 632 | 8260 | 0 | None | -6 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9325344 | |||||
| 633 | 8287 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 11112777 | |||||
| 49871766 | 9335 | 40 | None | -2 | 3 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 21036912 | |||
| 6170 | 9335 | 40 | None | -2 | 3 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 21036912 | |||
| CHEMBL1672354 | 9335 | 40 | None | -2 | 3 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 444 | 6 | 2 | 4 | 4.5 | FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F | 21036912 | |||
| 632 | 8260 | 0 | None | -1 | 5 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 10454496 | |||||
| 632 | 8260 | 0 | None | 1 | 5 | Rat | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 10454496 | |||||