Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
137642989 | 158235 | 0 | None | 5 | 4 | Mouse | 10.5 | pEC50 | = | 10.5 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1166 | 35 | 16 | 13 | -2.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4088263 | 158235 | 0 | None | 5 | 4 | Mouse | 10.5 | pEC50 | = | 10.5 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1166 | 35 | 16 | 13 | -2.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137635007 | 155977 | 0 | None | 10 | 4 | Mouse | 10.5 | pEC50 | = | 10.5 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1209 | 36 | 17 | 15 | -2.7 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4061507 | 155977 | 0 | None | 10 | 4 | Mouse | 10.5 | pEC50 | = | 10.5 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1209 | 36 | 17 | 15 | -2.7 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137640682 | 157052 | 0 | None | 7 | 4 | Mouse | 10.3 | pEC50 | = | 10.3 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1156 | 36 | 18 | 14 | -3.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4073946 | 157052 | 0 | None | 7 | 4 | Mouse | 10.3 | pEC50 | = | 10.3 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1156 | 36 | 18 | 14 | -3.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137633449 | 156589 | 0 | None | 3 | 4 | Mouse | 10.3 | pEC50 | = | 10.3 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1237 | 35 | 17 | 15 | -3.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4068681 | 156589 | 0 | None | 3 | 4 | Mouse | 10.3 | pEC50 | = | 10.3 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1237 | 35 | 17 | 15 | -3.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137646678 | 157686 | 0 | None | 2 | 4 | Mouse | 10.1 | pEC50 | = | 10.1 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1275 | 36 | 17 | 15 | -2.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4081760 | 157686 | 0 | None | 2 | 4 | Mouse | 10.1 | pEC50 | = | 10.1 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1275 | 36 | 17 | 15 | -2.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137652696 | 158962 | 0 | None | 3 | 4 | Mouse | 10.1 | pEC50 | = | 10.1 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1182 | 35 | 17 | 14 | -2.9 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4095998 | 158962 | 0 | None | 3 | 4 | Mouse | 10.1 | pEC50 | = | 10.1 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1182 | 35 | 17 | 14 | -2.9 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137660871 | 159143 | 0 | None | 1 | 4 | Mouse | 10.1 | pEC50 | = | 10.1 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1168 | 34 | 17 | 14 | -3.3 | CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4098010 | 159143 | 0 | None | 1 | 4 | Mouse | 10.1 | pEC50 | = | 10.1 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1168 | 34 | 17 | 14 | -3.3 | CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137640690 | 157071 | 0 | None | 1 | 4 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assay |
ChEMBL | 1288 | 35 | 17 | 15 | -1.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1016/j.bmcl.2017.09.019 | |
CHEMBL4074121 | 157071 | 0 | None | 1 | 4 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assay |
ChEMBL | 1288 | 35 | 17 | 15 | -1.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1016/j.bmcl.2017.09.019 | |
87415277 | 156125 | 0 | None | 1 | 4 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1287 | 35 | 17 | 15 | -2.2 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4063341 | 156125 | 0 | None | 1 | 4 | Mouse | 10.0 | pEC50 | = | 10.0 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1287 | 35 | 17 | 15 | -2.2 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137660871 | 159143 | 0 | None | -1 | 4 | Human | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1168 | 34 | 17 | 14 | -3.3 | CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4098010 | 159143 | 0 | None | -1 | 4 | Human | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1168 | 34 | 17 | 14 | -3.3 | CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137646678 | 157686 | 0 | None | -2 | 4 | Human | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1275 | 36 | 17 | 15 | -2.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4081760 | 157686 | 0 | None | -2 | 4 | Human | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1275 | 36 | 17 | 15 | -2.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137652435 | 157530 | 0 | None | 2 | 4 | Mouse | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1148 | 36 | 17 | 14 | -3.0 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4079986 | 157530 | 0 | None | 2 | 4 | Mouse | 9.8 | pEC50 | = | 9.8 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1148 | 36 | 17 | 14 | -3.0 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL3356083 | 211561 | 12 | None | 2 | 4 | Mouse | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |||
137640690 | 157071 | 0 | None | -1 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assay |
ChEMBL | 1288 | 35 | 17 | 15 | -1.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1016/j.bmcl.2017.09.019 | |
CHEMBL4074121 | 157071 | 0 | None | -1 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assay |
ChEMBL | 1288 | 35 | 17 | 15 | -1.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1016/j.bmcl.2017.09.019 | |
87415277 | 156125 | 0 | None | -1 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1287 | 35 | 17 | 15 | -2.2 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4063341 | 156125 | 0 | None | -1 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1287 | 35 | 17 | 15 | -2.2 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137636908 | 156161 | 0 | None | 2 | 4 | Mouse | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1188 | 35 | 17 | 14 | -2.2 | CC(C)C[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4063830 | 156161 | 0 | None | 2 | 4 | Mouse | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1188 | 35 | 17 | 14 | -2.2 | CC(C)C[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL3758577 | 212225 | 0 | None | 2 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assayAgonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2015.07.020 | |||
137633449 | 156589 | 0 | None | -3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1237 | 35 | 17 | 15 | -3.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4068681 | 156589 | 0 | None | -3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1237 | 35 | 17 | 15 | -3.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137642989 | 158235 | 0 | None | -9 | 4 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1166 | 35 | 16 | 13 | -2.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4088263 | 158235 | 0 | None | -9 | 4 | Human | 9.6 | pEC50 | = | 9.6 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1166 | 35 | 16 | 13 | -2.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137637194 | 155788 | 0 | None | 1 | 4 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1183 | 35 | 17 | 15 | -3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4059530 | 155788 | 0 | None | 1 | 4 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1183 | 35 | 17 | 15 | -3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137643754 | 158424 | 0 | None | 1 | 4 | Mouse | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1331 | 39 | 18 | 15 | -1.5 | CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4090300 | 158424 | 0 | None | 1 | 4 | Mouse | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1331 | 39 | 18 | 15 | -1.5 | CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL3759452 | 212231 | 0 | None | 1 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assayAgonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay |
ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2015.07.020 | |||
137635007 | 155977 | 0 | None | -10 | 4 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1209 | 36 | 17 | 15 | -2.7 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4061507 | 155977 | 0 | None | -10 | 4 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1209 | 36 | 17 | 15 | -2.7 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137637194 | 155788 | 0 | None | -1 | 4 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1183 | 35 | 17 | 15 | -3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4059530 | 155788 | 0 | None | -1 | 4 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1183 | 35 | 17 | 15 | -3.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
87415284 | 158553 | 0 | None | 1 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1232 | 35 | 17 | 14 | -1.8 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4091611 | 158553 | 0 | None | 1 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1232 | 35 | 17 | 14 | -1.8 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
137643907 | 158197 | 0 | None | 1 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1154 | 34 | 15 | 14 | -2.9 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL4087867 | 158197 | 0 | None | 1 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | 1154 | 34 | 15 | 14 | -2.9 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 | |
CHEMBL3356083 | 211561 | 12 | None | -2 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assayAgonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.7b00330 |
Showing 1 to 50 of 366 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
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Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
5280805 | 85405 | 81 | None | - | 3 | Human | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 610 | 6 | 10 | 16 | -1.7 | C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL226335 | 85405 | 81 | None | - | 3 | Human | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 610 | 6 | 10 | 16 | -1.7 | C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O | 10.1016/j.bmc.2014.08.038 | ||
101879981 | 1159 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 334 | 1 | 1 | 3 | 4.1 | Brc1ccc(c(c1)c1oc2ccccc2c(=O)c1O)F | 10.1016/j.bmc.2014.08.038 | ||
9010 | 1159 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 334 | 1 | 1 | 3 | 4.1 | Brc1ccc(c(c1)c1oc2ccccc2c(=O)c1O)F | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3343015 | 1159 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 334 | 1 | 1 | 3 | 4.1 | Brc1ccc(c(c1)c1oc2ccccc2c(=O)c1O)F | 10.1016/j.bmc.2014.08.038 | ||
118716778 | 115055 | 2 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 290 | 1 | 1 | 3 | 4.0 | O=c1c(O)c(-c2cccc(Cl)c2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3343013 | 115055 | 2 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 290 | 1 | 1 | 3 | 4.0 | O=c1c(O)c(-c2cccc(Cl)c2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
7728970 | 115054 | 3 | None | - | 0 | Human | 4.4 | pEC50 | = | 4.4 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 256 | 1 | 1 | 3 | 3.3 | O=c1c(O)c(-c2ccccc2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3343012 | 115054 | 3 | None | - | 0 | Human | 4.4 | pEC50 | = | 4.4 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 256 | 1 | 1 | 3 | 3.3 | O=c1c(O)c(-c2ccccc2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
118716784 | 115057 | 0 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 378 | 4 | 1 | 4 | 3.7 | O=c1c(OCCO)c(-c2cc(Br)ccc2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3343023 | 115057 | 0 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 378 | 4 | 1 | 4 | 3.7 | O=c1c(OCCO)c(-c2cc(Br)ccc2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3315349 | 211380 | 3 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.bmc.2014.08.038 | ||||
7172 | 116691 | 94 | None | - | 2 | Human | 5.2 | pEC50 | = | 5.2 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNCC(O)c1ccc(O)cc1 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL33720 | 116691 | 94 | None | - | 2 | Human | 5.2 | pEC50 | = | 5.2 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNCC(O)c1ccc(O)cc1 | 10.1016/j.bmc.2014.08.038 | ||
118716779 | 115056 | 0 | None | - | 0 | Human | 4.1 | pEC50 | = | 4.1 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 334 | 1 | 1 | 3 | 4.1 | O=c1c(O)c(-c2ccc(Br)cc2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3343014 | 115056 | 0 | None | - | 0 | Human | 4.1 | pEC50 | = | 4.1 | Binding | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assayAgonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay |
ChEMBL | 334 | 1 | 1 | 3 | 4.1 | O=c1c(O)c(-c2ccc(Br)cc2F)oc2ccccc12 | 10.1016/j.bmc.2014.08.038 | ||
CHEMBL3356083 | 211561 | 12 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||||
CHEMBL3356083 | 211561 | 12 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting methodDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acsmedchemlett.8b00105 | ||||
145955540 | 162606 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1139 | 29 | 16 | 14 | -2.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4169169 | 162606 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1139 | 29 | 16 | 14 | -2.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145950926 | 162758 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1153 | 33 | 15 | 13 | -1.9 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccccc1 | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4171697 | 162758 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1153 | 33 | 15 | 13 | -1.9 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccccc1 | 10.1016/j.ejmech.2017.12.035 | ||
145971940 | 163047 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 835 | 25 | 11 | 10 | -1.6 | CC(C)C[C@H](NC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4176146 | 163047 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 835 | 25 | 11 | 10 | -1.6 | CC(C)C[C@H](NC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145958560 | 162306 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1153 | 33 | 16 | 13 | -2.2 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4164449 | 162306 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1153 | 33 | 16 | 13 | -2.2 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145953783 | 162429 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1215 | 33 | 16 | 13 | -1.3 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4166325 | 162429 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1215 | 33 | 16 | 13 | -1.3 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145958189 | 162120 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting methodDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method |
ChEMBL | 1167 | 34 | 16 | 13 | -1.9 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acsmedchemlett.8b00105 | ||
CHEMBL4161479 | 162120 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting methodDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method |
ChEMBL | 1167 | 34 | 16 | 13 | -1.9 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acsmedchemlett.8b00105 | ||
145951684 | 162949 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1165 | 30 | 15 | 13 | -2.0 | CC(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4174679 | 162949 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1165 | 30 | 15 | 13 | -2.0 | CC(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145973626 | 163093 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1165 | 32 | 16 | 13 | -1.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21 | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4176945 | 163093 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1165 | 32 | 16 | 13 | -1.3 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21 | 10.1016/j.ejmech.2017.12.035 | ||
145949312 | 162886 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1173 | 32 | 16 | 13 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4173583 | 162886 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1173 | 32 | 16 | 13 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145953723 | 162642 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1207 | 33 | 16 | 13 | -1.1 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21 | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4169739 | 162642 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1207 | 33 | 16 | 13 | -1.1 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21 | 10.1016/j.ejmech.2017.12.035 | ||
145958420 | 162094 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1153 | 33 | 16 | 13 | -2.2 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4161037 | 162094 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1153 | 33 | 16 | 13 | -2.2 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145956001 | 162621 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1111 | 32 | 15 | 13 | -2.1 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccccc1 | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4169433 | 162621 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1111 | 32 | 15 | 13 | -2.1 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccccc1 | 10.1016/j.ejmech.2017.12.035 | ||
145950548 | 162839 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1115 | 29 | 15 | 13 | -2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21 | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4172829 | 162839 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1115 | 29 | 15 | 13 | -2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21 | 10.1016/j.ejmech.2017.12.035 | ||
145954330 | 162517 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1155 | 32 | 17 | 14 | -2.1 | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4167677 | 162517 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1155 | 32 | 17 | 14 | -2.1 | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2017.12.035 | ||
145959870 | 162008 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting methodDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method |
ChEMBL | 1243 | 35 | 16 | 13 | -0.4 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)NCc1ccccc1)C(N)=O | 10.1021/acsmedchemlett.8b00105 | ||
CHEMBL4159554 | 162008 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting methodDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method |
ChEMBL | 1243 | 35 | 16 | 13 | -0.4 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)NCc1ccccc1)C(N)=O | 10.1021/acsmedchemlett.8b00105 | ||
145953216 | 162556 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1169 | 33 | 16 | 14 | -2.2 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccc(O)cc1 | 10.1016/j.ejmech.2017.12.035 | ||
CHEMBL4168351 | 162556 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation countingDisplacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting |
ChEMBL | 1169 | 33 | 16 | 14 | -2.2 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccc(O)cc1 | 10.1016/j.ejmech.2017.12.035 |
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