Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 118037818 | 134778 | None | 0 | Human | Functional | pAC50 | = | 5.5 | 5.5 | 1 | 2 | Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay |
ChEMBL | 428 | 4 | 2 | 4 | 4.9 | O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2 | nan | ||
| CHEMBL3718470 | 134778 | None | 0 | Human | Functional | pAC50 | = | 5.5 | 5.5 | 1 | 2 | Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay |
ChEMBL | 428 | 4 | 2 | 4 | 4.9 | O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2 | nan | ||
| 90010773 | 133980 | None | 0 | Human | Functional | pAC50 | = | 5.1 | 5.1 | 1 | 2 | Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay |
ChEMBL | 375 | 4 | 2 | 4 | 4.2 | O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1 | nan | ||
| CHEMBL3715750 | 133980 | None | 0 | Human | Functional | pAC50 | = | 5.1 | 5.1 | 1 | 2 | Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay |
ChEMBL | 375 | 4 | 2 | 4 | 4.2 | O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1 | nan | ||
| 127024071 | 134094 | None | 0 | Human | Functional | pAC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay |
ChEMBL | 361 | 4 | 3 | 2 | 4.9 | O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1 | nan | ||
| CHEMBL3716158 | 134094 | None | 0 | Human | Functional | pAC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay |
ChEMBL | 361 | 4 | 3 | 2 | 4.9 | O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1 | nan | ||
| 12503 | 1127 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells. |
Guide to Pharmacology | 787 | 5 | 1 | 5 | 6.6 | FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1 | 36333465 | ||
| 167993647 | 1127 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells. |
Guide to Pharmacology | 787 | 5 | 1 | 5 | 6.6 | FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1 | 36333465 | ||
| 11914 | 2045 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Receptor activationReceptor activation |
Guide to Pharmacology | None | None | None | None | 22654853 | ||||
| 8346 | 202 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -165 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 21878627 | ||||
| 1989 | 3305 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -17 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
Showing 1 to 11 of 11 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11913 | 2731 | None | 0 | Human | Binding | pKd | = | 8.7 | 8.7 | - | 1 | Receptor binding affinityReceptor binding affinity |
Guide to Pharmacology | None | None | None | None | 24056075 | ||||
| 1995 | 2044 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | 16982 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 3875 | 1599 | None | 0 | Human | Binding | pKd | = | 9 | 9.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18529069 | ||||
| 11914 | 2045 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Receptor bindingReceptor binding |
Guide to Pharmacology | None | None | None | None | 22654853 | ||||
| 3885 | 2046 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 16547350 | ||||
| 8346 | 202 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -9 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 21878627 | ||||
| 8333 | 1279 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 17120268 | ||||
| 8332 | 282 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 20570702 | ||||
| 1989 | 3305 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -40 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 15649866 | ||||
| 1989 | 3305 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -40 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 155817469 | 2047 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 20560146 | ||||
| 4372 | 2047 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 20560146 | ||||
| 8331 | 233 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 20570702 | ||||
| 155817501 | 190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 8330 | 190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 134813893 | 214 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 8329 | 214 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 1995 | 2044 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 16982 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 15649866 | ||||
| 1995 | 2044 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 16982 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 18434306 | ||||
| 1990 | 3307 | None | 0 | Human | Binding | pKi | None | 7 | 7.0 | -81 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 16411781 | ||||
| 1994 | 3302 | None | 0 | Human | Binding | pKi | None | 7.8 | 7.8 | -39 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 15649866 | ||||
| 1992 | 3303 | None | 0 | Human | Binding | pKi | None | 7.9 | 7.9 | -15 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 15649866 | ||||
| 1988 | 3306 | None | 0 | Human | Binding | pKi | None | 8.8 | 8.8 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 16411781 | ||||
Showing 1 to 23 of 23 entries