ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	164616580	192106	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	297	4	2	1	4.3	Cc1cc(F)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4859651	192106	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	297	4	2	1	4.3	Cc1cc(F)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	17754443	187031	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at GPR40 expressed in CHO cells by FLIPR assayAgonist activity at GPR40 expressed in CHO cells by FLIPR assay	ChEMBL	370	3	1	3	4.7	O=C(O)[C@@H]1[C@H]2c3ccc(Oc4ccc(C(F)(F)F)cc4Cl)cc3O[C@H]21	10.1016/j.bmcl.2008.10.085
	CHEMBL475027	187031	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at GPR40 expressed in CHO cells by FLIPR assayAgonist activity at GPR40 expressed in CHO cells by FLIPR assay	ChEMBL	370	3	1	3	4.7	O=C(O)[C@@H]1[C@H]2c3ccc(Oc4ccc(C(F)(F)F)cc4Cl)cc3O[C@H]21	10.1016/j.bmcl.2008.10.085
	155551422	180746	0	None	-15	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	454	9	1	3	6.8	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(C)(C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4541658	180746	0	None	-15	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	454	9	1	3	6.8	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(C)(C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	134465732	178254	0	None	-1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4463571	178254	0	None	-1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	164615766	191788	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	313	4	2	1	4.8	Cc1cc(Cl)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4854804	191788	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	313	4	2	1	4.8	Cc1cc(Cl)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	134465794	177857	0	None	-4	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4457303	177857	0	None	-4	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	91827421	156038	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assay	ChEMBL	529	9	1	3	7.0	CC(c1cc(C(F)(F)F)ccc1C(F)(F)F)N1CC(COc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)C1	10.1016/j.bmcl.2016.10.074
	CHEMBL3944424	156038	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assay	ChEMBL	529	9	1	3	7.0	CC(c1cc(C(F)(F)F)ccc1C(F)(F)F)N1CC(COc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)C1	10.1016/j.bmcl.2016.10.074
	155551422	180746	0	None	15	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	454	9	1	3	6.8	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(C)(C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4541658	180746	0	None	15	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	454	9	1	3	6.8	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(C)(C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	134465794	177857	0	None	4	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4457303	177857	0	None	4	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	24857286	8405	72	None	-3	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	6484	8405	72	None	-3	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	CHEMBL1829174	8405	72	None	-3	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	DB12491	8405	72	None	-3	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	164613862	191385	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	313	4	2	1	4.8	Cc1c(Cl)cccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4848974	191385	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	313	4	2	1	4.8	Cc1c(Cl)cccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	89671280	153466	0	None	10	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay	ChEMBL	406	5	3	3	4.1	CC#C[C@@H](CC(=O)O)c1ccc(NC(=O)C(=O)Nc2cccc(C(C)(C)C)c2)cc1	10.1016/j.bmcl.2016.10.074
	CHEMBL3923877	153466	0	None	10	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay	ChEMBL	406	5	3	3	4.1	CC#C[C@@H](CC(=O)O)c1ccc(NC(=O)C(=O)Nc2cccc(C(C)(C)C)c2)cc1	10.1016/j.bmcl.2016.10.074
	134465732	178254	0	None	1	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4463571	178254	0	None	1	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	164617551	192090	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c(C)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4859407	192090	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c(C)c1	10.1021/acs.jmedchem.1c00031
	142738582	191299	0	None	42	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4847662	191299	0	None	42	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	137333449	174388	5	None	10	2	Rat	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165147	174388	5	None	10	2	Rat	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301092	174388	5	None	10	2	Rat	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	86288852	118031	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	522	11	1	6	6.6	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265149	118031	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	522	11	1	6	6.6	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
	52936292	188889	27	None	-7	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4782004	188889	27	None	-7	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	164619456	192928	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1cccc(C)c1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4872298	192928	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1cccc(C)c1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	164610330	191976	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	357	4	2	1	4.9	Cc1cc(Br)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4857550	191976	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	357	4	2	1	4.9	Cc1cc(Br)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	137333449	174388	5	None	-10	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165147	174388	5	None	-10	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301092	174388	5	None	-10	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	118638016	174431	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163182	174431	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301725	174431	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	134465785	182890	0	None	-15	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4591657	182890	0	None	-15	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	68194465	190085	0	None	-3	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4797124	190085	0	None	-3	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	118151370	165882	0	None	7	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4097527	165882	0	None	7	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	155549083	180447	0	None	6	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4534836	180447	0	None	6	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	118623101	174368	0	None	-12	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159416	174368	0	None	-12	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300796	174368	0	None	-12	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	90357232	149030	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884803	149030	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	51049992	152397	5	None	-23	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL3915620	152397	5	None	-23	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	118638009	174432	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4160527	174432	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301726	174432	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	118623101	174368	0	None	12	2	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159416	174368	0	None	12	2	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300796	174368	0	None	12	2	Rat	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	15604310	118578	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	462	8	1	6	5.0	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nnnn3C)cc2)c1	10.1021/ml400501x
	CHEMBL3287571	118578	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	462	8	1	6	5.0	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nnnn3C)cc2)c1	10.1021/ml400501x
	46854655	7183	47	None	-8	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
	6485	7183	47	None	-8	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
	CHEMBL1829173	7183	47	None	-8	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
	68194476	189666	0	None	-6	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4792075	189666	0	None	-6	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
	118638010	174344	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165008	174344	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300503	174344	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	90372613	174523	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4166625	174523	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302869	174523	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	90655860	118026	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	518	10	1	5	7.1	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265144	118026	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	518	10	1	5	7.1	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	118637996	148948	0	None	-15	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883819	148948	0	None	-15	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4162778	148948	0	None	-15	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	118637996	148948	0	None	-15	2	Human	8.8	pEC50	=	8.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883819	148948	0	None	-15	2	Human	8.8	pEC50	=	8.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL4162778	148948	0	None	-15	2	Human	8.8	pEC50	=	8.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	162668378	189286	0	None	-4	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4787010	189286	0	None	-4	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
	90372625	174500	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159022	174500	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302640	174500	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	145980154	173416	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	372	9	1	3	4.8	CC#C[C@@H](CC(=O)O)c1ccc(OCCCOc2cccc(Cl)c2)cc1	10.1016/j.ejmech.2018.09.071
	CHEMBL4281133	173416	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	372	9	1	3	4.8	CC#C[C@@H](CC(=O)O)c1ccc(OCCCOc2cccc(Cl)c2)cc1	10.1016/j.ejmech.2018.09.071
	44572097	196330	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	402	6	1	3	6.1	CC#CC(CC(=O)O)c1ccc(OC2CCc3cc(-c4cccs4)ccc32)cc1	10.1016/j.bmcl.2008.10.085
	CHEMBL514337	196330	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	402	6	1	3	6.1	CC#CC(CC(=O)O)c1ccc(OC2CCc3cc(-c4cccs4)ccc32)cc1	10.1016/j.bmcl.2008.10.085
	134144239	157246	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	543	8	1	3	7.9	COc1ccc(F)c(-c2ccc(Cc3cccc(N4C[C@H](c5cccc(Cl)c5)C[C@@H]4CC(=O)O)c3)c(C)c2)c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3954235	157246	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	543	8	1	3	7.9	COc1ccc(F)c(-c2ccc(Cc3cccc(N4C[C@H](c5cccc(Cl)c5)C[C@@H]4CC(=O)O)c3)c(C)c2)c1	10.1016/j.bmcl.2016.10.074
	131986136	170404	0	None	3	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	512	8	1	6	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4203795	170404	0	None	3	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	512	8	1	6	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	3367	7939	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1016/j.bmcl.2009.10.052
	46216676	7939	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1016/j.bmcl.2009.10.052
	CHEMBL604126	7939	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1016/j.bmcl.2009.10.052
	46232307	209345	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(C2CC2C(=O)O)cc1	10.1016/j.bmcl.2009.10.052
	CHEMBL611821	209345	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(C2CC2C(=O)O)cc1	10.1016/j.bmcl.2009.10.052
	90644300	118744	0	None	31	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288358	118744	0	None	31	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	23111694	80834	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	494	9	1	4	7.1	Cc1cccc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1OCc1ccccc1	10.1021/jm2012968
	CHEMBL2022256	80834	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	494	9	1	4	7.1	Cc1cccc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1OCc1ccccc1	10.1021/jm2012968
	68194237	188985	0	None	-4	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4783033	188985	0	None	-4	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	131986401	170763	0	None	1	2	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4208095	170763	0	None	1	2	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	134140733	153942	0	None	-	1	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay	ChEMBL	358	8	1	3	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCCOc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2016.10.074
	CHEMBL3927863	153942	0	None	-	1	Rat	8.0	pEC50	=	8	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay	ChEMBL	358	8	1	3	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCCOc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2016.10.074
	134137874	159760	0	None	1995	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 formation after 1 hr by ELISAAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 formation after 1 hr by ELISA	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
	CHEMBL3930086	159760	0	None	1995	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 formation after 1 hr by ELISAAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 formation after 1 hr by ELISA	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
	CHEMBL3975239	159760	0	None	1995	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 formation after 1 hr by ELISAAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 formation after 1 hr by ELISA	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
	44409843	147183	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	473	7	2	4	6.4	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC(C)C)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL380884	147183	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	473	7	2	4	6.4	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC(C)C)cc1	10.1016/j.bmcl.2006.01.007
	57706620	170663	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	530	11	1	3	8.7	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)CC4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4206969	170663	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	530	11	1	3	8.7	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)CC4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	57707179	171284	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	534	10	1	3	8.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3F)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4214632	171284	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	534	10	1	3	8.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3F)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	46854655	7183	47	None	-8	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/jm2005699
	6485	7183	47	None	-8	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/jm2005699
	CHEMBL1829173	7183	47	None	-8	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/jm2005699
	1050	8683	94	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2009.10.052
	11595431	8683	94	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2009.10.052
	CHEMBL207881	8683	94	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2009.10.052
	122185437	129455	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	360	11	1	5	3.8	CCOC(CC(=O)O)c1ccc(OCc2cccc(OCOC)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604043	129455	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	360	11	1	5	3.8	CCOC(CC(=O)O)c1ccc(OCc2cccc(OCOC)c2)cc1	10.1016/j.bmc.2015.07.028
	121294359	186365	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	615	14	1	7	6.4	COc1ccc(C(=O)N(CC(C)(C)OC)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4742099	186365	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	615	14	1	7	6.4	COc1ccc(C(=O)N(CC(C)(C)OC)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	121294251	186736	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	536	11	1	5	6.1	COc1ccc(C(=O)N(C)CC(C)(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4746614	186736	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	536	11	1	5	6.1	COc1ccc(C(=O)N(C)CC(C)(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	90151370	162694	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	525	7	1	6	5.6	COc1ccc(Cl)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4060840	162694	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	525	7	1	6	5.6	COc1ccc(Cl)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	145987015	173821	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#CC(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4288867	173821	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#CC(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	54583582	68938	0	None	-2	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	431	6	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OC2CCCc3nc(-c4ccc(C)cc4)sc32)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777872	68938	0	None	-2	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	431	6	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OC2CCCc3nc(-c4ccc(C)cc4)sc32)cc1	10.1016/j.bmcl.2011.03.114
	44409728	81827	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	361	8	2	3	5.4	CC(Cc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1)C(=O)O	10.1016/j.bmcl.2006.01.007
	CHEMBL203520	81827	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	361	8	2	3	5.4	CC(Cc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1)C(=O)O	10.1016/j.bmcl.2006.01.007
	44409670	82737	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	461	8	2	4	6.2	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CCC(=O)NC(C)C)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL205263	82737	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	461	8	2	4	6.2	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CCC(=O)NC(C)C)cc1	10.1016/j.bmcl.2006.01.007
	20331242	94601	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	289	6	2	2	4.0	O=C(O)CCc1ccc(NCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL233835	94601	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	289	6	2	2	4.0	O=C(O)CCc1ccc(NCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2006.12.084
	58319107	93322	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	326	4	1	1	4.8	O=C(O)CCc1ccc(C#Cc2ccccc2-c2ccccc2)cc1	10.1021/jm301470a
	CHEMBL2315546	93322	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	326	4	1	1	4.8	O=C(O)CCc1ccc(C#Cc2ccccc2-c2ccccc2)cc1	10.1021/jm301470a
	71562312	93333	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	4	1	1	3.5	O=C(O)CCCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	CHEMBL2315557	93333	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	4	1	1	3.5	O=C(O)CCCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	146314511	187400	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	508	13	1	5	6.0	COc1ccc(CN(C)CC(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4754718	187400	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	508	13	1	5	6.0	COc1ccc(CN(C)CC(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	23136477	65604	3	None	-15	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688455	65604	3	None	-15	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4213909	65604	3	None	-15	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	137643339	164822	0	None	-26	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	164822	0	None	-26	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	46232308	207865	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	367	4	1	4	4.7	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL602867	207865	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	367	4	1	4	4.7	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	134130696	148915	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	CHEMBL3883449	148915	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	142738543	168886	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	349	5	2	2	4.8	O=C(O)CCc1ccc2[nH]c(-c3ccccc3OC(F)(F)F)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4161206	168886	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	349	5	2	2	4.8	O=C(O)CCc1ccc2[nH]c(-c3ccccc3OC(F)(F)F)cc2c1	10.1021/acsmedchemlett.7b00460
	127046664	146604	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	453	9	1	5	6.0	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OC2CCCC2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798992	146604	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	453	9	1	5	6.0	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OC2CCCC2)c1	10.1016/j.ejmech.2016.03.054
	155549391	180616	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	466	7	1	5	5.0	O=C(O)CC1(c2ccc(OC[C@H]3COc4ccc(-c5ccc(Cl)cc5)cc4O3)cc2)COC1	10.1016/j.bmcl.2019.01.014
	CHEMBL4538821	180616	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	466	7	1	5	5.0	O=C(O)CC1(c2ccc(OC[C@H]3COc4ccc(-c5ccc(Cl)cc5)cc4O3)cc2)COC1	10.1016/j.bmcl.2019.01.014
	145970056	171552	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	475	9	2	5	5.3	O=C(O)CCc1ccc(NC(=O)c2nnc(CC(c3ccccc3)c3ccccc3F)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4218014	171552	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	475	9	2	5	5.3	O=C(O)CCc1ccc(NC(=O)c2nnc(CC(c3ccccc3)c3ccccc3F)s2)cc1	10.1016/j.ejmech.2017.09.019
	137643339	164822	0	None	-26	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	164822	0	None	-26	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	122193743	130750	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	454	11	1	5	5.2	COCCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3628763	130750	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	454	11	1	5	5.2	COCCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	145969681	171768	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	392	6	1	5	4.2	Cc1nn(C)c(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4225643	171768	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	392	6	1	5	4.2	Cc1nn(C)c(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	145984886	173218	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	415	7	1	6	4.2	O=C(O)CC(c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1)c1cnco1	10.1016/j.bmc.2018.10.019
	CHEMBL4277516	173218	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	415	7	1	6	4.2	O=C(O)CC(c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1)c1cnco1	10.1016/j.bmc.2018.10.019
	168290747	198702	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	420	10	1	5	4.9	COc1ccc(/C=C/c2cc(OC)cc(OCc3ccc(OCC(=O)O)cc3)c2)cc1	10.1016/j.ejmech.2021.114061
	CHEMBL5200259	198702	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	420	10	1	5	4.9	COc1ccc(/C=C/c2cc(OC)cc(OCc3ccc(OCC(=O)O)cc3)c2)cc1	10.1016/j.ejmech.2021.114061
	90356885	174314	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4168422	174314	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300181	174314	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	53248847	68921	0	None	1	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	CHEMBL1777855	68921	0	None	1	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	134150245	159024	0	None	-117	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	159024	0	None	-117	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	118638016	174431	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163182	174431	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301725	174431	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	71612894	96756	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	408	3	1	4	4.1	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cc(F)cc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381292	96756	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	408	3	1	4	4.1	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cc(F)cc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	122193737	130748	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	438	10	1	4	5.9	CCCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3628757	130748	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	438	10	1	4	5.9	CCCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	57521809	83039	0	None	-13	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058520	83039	0	None	-13	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4210970	83039	0	None	-13	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	145971234	169860	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	453	7	1	3	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCc4ccccc4C3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4176612	169860	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	453	7	1	3	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCc4ccccc4C3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	127051302	147094	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	383	8	2	6	3.4	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccccc3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3806208	147094	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	383	8	2	6	3.4	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccccc3)s2)cc1	10.1016/j.bmc.2016.04.065
	127049498	147019	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	417	8	2	6	4.0	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3cccc(Cl)c3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805377	147019	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	417	8	2	6	4.0	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3cccc(Cl)c3)s2)cc1	10.1016/j.bmc.2016.04.065
	131986147	171558	0	None	-6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	456	7	1	5	6.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCCC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218110	171558	0	None	-6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	456	7	1	5	6.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCCC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	25150121	191961	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	Cc1ccc(C#Cc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm8010178
	CHEMBL485738	191961	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	Cc1ccc(C#Cc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm8010178
	75511303	129233	3	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	341	7	1	4	4.1	O=C(O)CCc1ccc(OCc2ncc(-c3cccc(F)c3)o2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600997	129233	3	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	341	7	1	4	4.1	O=C(O)CCc1ccc(OCc2ncc(-c3cccc(F)c3)o2)cc1	10.1016/j.bmcl.2015.06.018
	54757735	72119	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	341	4	1	2	4.5	Cc1ccccc1-c1cc(C#Cc2ccc(CCC(=O)O)cc2)ccn1	10.1021/jm2005699
	CHEMBL1829163	72119	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	341	4	1	2	4.5	Cc1ccccc1-c1cc(C#Cc2ccc(CCC(=O)O)cc2)ccn1	10.1021/jm2005699
	54582150	68584	0	None	22	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1773259	68584	0	None	22	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/ml100106c
	54582630	68932	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777866	68932	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	131986297	170984	0	None	-1	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4210878	170984	0	None	-1	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	122189677	130133	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	333	7	2	4	2.6	Cc1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616657	130133	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	333	7	2	4	2.6	Cc1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	46231436	207178	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	311	5	1	3	3.4	O=C1NC(=O)C(Cc2ccc(CCc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL598040	207178	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	311	5	1	3	3.4	O=C1NC(=O)C(Cc2ccc(CCc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	46231655	207893	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1cccnc1Oc1ccc(CC2SC(=O)NC2=O)cc1	10.1016/j.bmcl.2009.10.052
	CHEMBL603065	207893	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1cccnc1Oc1ccc(CC2SC(=O)NC2=O)cc1	10.1016/j.bmcl.2009.10.052
	145951164	169573	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	473	8	2	4	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)NC3CCCc4ccccc43)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4172250	169573	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	473	8	2	4	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)NC3CCCc4ccccc43)s2)cc1	10.1016/j.ejmech.2018.04.023
	122193972	130756	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	454	11	2	5	4.9	Cc1cc(OCCCO)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3629046	130756	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	454	11	2	5	4.9	Cc1cc(OCCCO)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	57521917	83050	0	None	8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058530	83050	0	None	8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	168298569	199458	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1cccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)c1	10.1016/j.ejmech.2022.114645
	CHEMBL5219055	199458	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1cccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)c1	10.1016/j.ejmech.2022.114645
	25150113	178413	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	265	3	2	2	2.7	Nc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL446575	178413	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	265	3	2	2	2.7	Nc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	54757515	72102	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	296	4	1	4	2.4	O=C(O)CCc1ccc(C#Cc2ncccc2[N+](=O)[O-])cc1	10.1021/jm2005699
	CHEMBL1829147	72102	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	296	4	1	4	2.4	O=C(O)CCc1ccc(C#Cc2ncccc2[N+](=O)[O-])cc1	10.1021/jm2005699
	146314448	186906	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	507	12	1	4	7.3	COc1ccc(CCCC(C)(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4748702	186906	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	507	12	1	4	7.3	COc1ccc(CCCC(C)(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	134538585	170414	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	518	9	3	5	6.3	Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	CHEMBL4203974	170414	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	518	9	3	5	6.3	Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	15603842	118577	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	461	8	1	5	5.6	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3ncnn3C)cc2)c1	10.1021/ml400501x
	CHEMBL3287570	118577	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	461	8	1	5	5.6	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3ncnn3C)cc2)c1	10.1021/ml400501x
	91809187	153902	13	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL3927519	153902	13	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	118645715	188266	0	None	1	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	6.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764729	188266	0	None	1	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	6.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	162668241	189285	0	None	4	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4787007	189285	0	None	4	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	67087041	189150	0	None	-14	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4785057	189150	0	None	-14	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	162676881	190364	0	None	-10	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4800563	190364	0	None	-10	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	68194237	188985	0	None	-4	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4783033	188985	0	None	-4	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	45107312	125911	5	None	-2	2	Rat	8.0	pEC50	=	8.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427712	125911	5	None	-2	2	Rat	8.0	pEC50	=	8.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at rat GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1016/j.bmc.2015.07.028
	118642390	169463	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4170346	169463	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	155544661	181724	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	443	8	1	4	6.0	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)ccn1	10.1016/j.bmcl.2019.04.050
	CHEMBL4565467	181724	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	443	8	1	4	6.0	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)ccn1	10.1016/j.bmcl.2019.04.050
	127045659	146471	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1ccc(F)c(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798044	146471	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1ccc(F)c(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	71613520	96753	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.2	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381289	96753	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.2	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	57706778	87572	29	None	8	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL2152070	87572	29	None	8	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	147329931	182181	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	409	9	2	4	5.3	CCOc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4575598	182181	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	409	9	2	4	5.3	CCOc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	134137874	159760	0	None	1995	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular Ca2+ flux preincubated for 40 mins measured for 180 secs by fluo-4 NW dye-based assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular Ca2+ flux preincubated for 40 mins measured for 180 secs by fluo-4 NW dye-based assay	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
	CHEMBL3930086	159760	0	None	1995	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular Ca2+ flux preincubated for 40 mins measured for 180 secs by fluo-4 NW dye-based assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular Ca2+ flux preincubated for 40 mins measured for 180 secs by fluo-4 NW dye-based assay	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
	CHEMBL3975239	159760	0	None	1995	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular Ca2+ flux preincubated for 40 mins measured for 180 secs by fluo-4 NW dye-based assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular Ca2+ flux preincubated for 40 mins measured for 180 secs by fluo-4 NW dye-based assay	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
	168273613	197047	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	468	6	1	5	5.6	O=C(O)C[C@@H]1COc2cc(OCc3ccc4nc(-c5ccc(C(F)(F)F)cc5)cn4c3)ccc21	10.1016/j.bmcl.2021.127969
	CHEMBL5175525	197047	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	468	6	1	5	5.6	O=C(O)C[C@@H]1COc2cc(OCc3ccc4nc(-c5ccc(C(F)(F)F)cc5)cn4c3)ccc21	10.1016/j.bmcl.2021.127969
	57705555	170379	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	518	11	1	3	8.7	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4203561	170379	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	518	11	1	3	8.7	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	57400637	76798	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#CC(CC(=O)O)c1ccc(OCc2cccc(OC)c2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939650	76798	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#CC(CC(=O)O)c1ccc(OCc2cccc(OC)c2)cc1	10.1016/j.bmcl.2011.10.118
	137644989	165294	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	391	7	1	4	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C#N)CC(=O)O)s2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4091211	165294	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	391	7	1	4	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C#N)CC(=O)O)s2)c1	10.1021/acs.jmedchem.6b01357
	132606863	164602	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4083365	164602	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	58218709	165197	0	None	4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c1C	10.1021/acs.jmedchem.6b01559
	CHEMBL4090240	165197	0	None	4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c1C	10.1021/acs.jmedchem.6b01559
	90151764	163781	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	526	7	1	7	5.0	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4073270	163781	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	526	7	1	7	5.0	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	77845055	166564	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	7	1	6	5.1	COc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4105324	166564	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	7	1	6	5.1	COc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	145990980	173538	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(Cl)ccc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4283655	173538	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(Cl)ccc3O2)cc1	10.1016/j.bmc.2018.10.019
	122193742	130749	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	396	7	2	4	4.9	Cc1cc(O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3628762	130749	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	396	7	2	4	4.9	Cc1cc(O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	23136315	65605	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccccc2Oc2ccccc2)cc1	10.1021/jm101405t
	CHEMBL1688456	65605	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccccc2Oc2ccccc2)cc1	10.1021/jm101405t
	25261464	87573	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	CHEMBL2152071	87573	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	57395404	76785	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	286	7	1	3	3.3	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939637	76785	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	286	7	1	3	3.3	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2011.10.118
	58218607	162719	0	None	-7	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2C[C@@H](C)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4061093	162719	0	None	-7	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2C[C@@H](C)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	137661475	166237	0	None	1	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4101348	166237	0	None	1	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	137651153	163983	0	None	-1	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4076004	163983	0	None	-1	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	90644294	118738	0	None	-13	2	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(C)n2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288352	118738	0	None	-13	2	Rat	6.0	pEC50	=	6.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(C)n2)c1	10.1016/j.bmcl.2014.04.065
	124011385	173639	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	344	5	1	3	4.5	O=C(O)C#Cc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.ejmech.2018.08.075
	CHEMBL4285594	173639	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	344	5	1	3	4.5	O=C(O)C#Cc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.ejmech.2018.08.075
	137635388	162603	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	407	6	1	3	5.8	O=C(O)CC1CCCCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4059947	162603	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	407	6	1	3	5.8	O=C(O)CC1CCCCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	137646043	164566	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	385	6	1	2	5.4	Cc1ccccc1Cc1ccc(N2CC[C@H](c3ccccc3)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4082975	164566	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	385	6	1	2	5.4	Cc1ccccc1Cc1ccc(N2CC[C@H](c3ccccc3)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	145985122	172687	0	None	-17	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250132	172687	0	None	-17	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	1049	7151	75	None	1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.ejmech.2018.08.075
	4618	7151	75	None	1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.ejmech.2018.08.075
	5280934	7151	75	None	1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.ejmech.2018.08.075
	CHEMBL8739	7151	75	None	1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.ejmech.2018.08.075
	DB00132	7151	75	None	1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.ejmech.2018.08.075
	71613515	96748	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381283	96748	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	86803185	129242	5	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	392	7	1	5	4.4	O=C(O)CCc1ccc(OCc2nc(-c3cccc(C(F)(F)F)c3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601006	129242	5	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	392	7	1	5	4.4	O=C(O)CCc1ccc(OCc2nc(-c3cccc(C(F)(F)F)c3)no2)cc1	10.1016/j.bmcl.2015.06.018
	137629942	167804	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	558	12	1	6	6.2	Cc1ccnc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)c1	10.1016/j.ejmech.2017.01.005
	CHEMBL4071849	167804	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	558	12	1	6	6.2	Cc1ccnc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)c1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116363	167804	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	558	12	1	6	6.2	Cc1ccnc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)c1	10.1016/j.ejmech.2017.01.005
	54757626	72113	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	265	3	1	2	2.8	Cc1cc(C#Cc2ccc(CCC(=O)O)cc2)ccn1	10.1021/jm2005699
	CHEMBL1829157	72113	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	265	3	1	2	2.8	Cc1cc(C#Cc2ccc(CCC(=O)O)cc2)ccn1	10.1021/jm2005699
	24825481	82700	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	361	9	2	3	5.5	O=C(O)CCCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL205090	82700	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	361	9	2	3	5.5	O=C(O)CCCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	134141270	153588	0	None	-35	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	153588	0	None	-35	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	15605424	207345	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	299	4	1	4	3.4	O=C1NC(=O)C(Cc2ccccc2Oc2ccccc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL599067	207345	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	299	4	1	4	3.4	O=C1NC(=O)C(Cc2ccccc2Oc2ccccc2)S1	10.1016/j.bmcl.2009.10.052
	53248847	68921	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	CHEMBL1777855	68921	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	145950728	169549	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccc4F)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4171827	169549	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccc4F)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	86803196	129243	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	324	7	1	5	3.3	O=C(O)CCc1ccc(OCc2nc(-c3ccccc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601007	129243	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	324	7	1	5	3.3	O=C(O)CCc1ccc(OCc2nc(-c3ccccc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	145966017	171122	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	8	2	6	4.0	Cc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1C	10.1016/j.ejmech.2017.09.019
	CHEMBL4212573	171122	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	8	2	6	4.0	Cc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1C	10.1016/j.ejmech.2017.09.019
	145954950	168424	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	501	9	1	5	5.8	O=C1NC(=O)C(Cc2ccc(OCCOC(c3ccccc3)c3ccc(C(F)(F)F)cc3)cc2)S1	10.1016/j.bmcl.2018.03.051
	CHEMBL4130213	168424	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	501	9	1	5	5.8	O=C1NC(=O)C(Cc2ccc(OCCOC(c3ccccc3)c3ccc(C(F)(F)F)cc3)cc2)S1	10.1016/j.bmcl.2018.03.051
	145953265	169406	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	489	8	1	6	4.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4cccnc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4169459	169406	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	489	8	1	6	4.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4cccnc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	54580625	68939	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	272	5	1	2	3.6	CC#CC(CC(=O)O)c1ccc(OC2CCCC2)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777873	68939	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	272	5	1	2	3.6	CC#CC(CC(=O)O)c1ccc(OC2CCCC2)cc1	10.1016/j.bmcl.2011.03.114
	127045658	146557	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	437	7	1	4	5.7	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(C(F)(F)F)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798642	146557	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	437	7	1	4	5.7	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(C(F)(F)F)c1	10.1016/j.ejmech.2016.03.054
	145958971	168965	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	500	8	1	4	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4162561	168965	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	500	8	1	4	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	44409702	147764	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	400	8	1	3	5.6	O=C(CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1)N1CCCC1	10.1016/j.bmcl.2006.01.007
	CHEMBL382341	147764	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	400	8	1	3	5.6	O=C(CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1)N1CCCC1	10.1016/j.bmcl.2006.01.007
	137630875	167901	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	573	12	1	7	5.9	Cc1cnc(C)c(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)n1	10.1016/j.ejmech.2017.01.005
	CHEMBL4091587	167901	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	573	12	1	7	5.9	Cc1cnc(C)c(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)n1	10.1016/j.ejmech.2017.01.005
	CHEMBL4117177	167901	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	573	12	1	7	5.9	Cc1cnc(C)c(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)n1	10.1016/j.ejmech.2017.01.005
	57521813	83043	0	None	1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058524	83043	0	None	1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	23346507	95063	1	None	30	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL234834	95063	1	None	30	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	3893	9067	98	None	-1	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	4642	9067	98	None	-1	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	5534	9067	98	None	-1	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL108766	9067	98	None	-1	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	DB03017	9067	98	None	-1	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	643684	114292	63	None	-8	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL3186422	114292	63	None	-8	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	122189680	130135	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	361	8	2	4	3.4	CC(C)c1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616660	130135	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	361	8	2	4	3.4	CC(C)c1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	127025284	144524	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	417	6	1	4	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759212	144524	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	417	6	1	4	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.ejmech.2015.12.049
	82051616	166236	1	None	-12	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	166236	1	None	-12	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	134130823	161217	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	529	11	1	5	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3ccccc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3890182	161217	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	529	11	1	5	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3ccccc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990066	161217	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	529	11	1	5	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3ccccc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	118129974	163973	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4075819	163973	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	145994052	174134	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	425	7	1	5	4.6	O=C(O)CC(c1ccncc1)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4294582	174134	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	425	7	1	5	4.6	O=C(O)CC(c1ccncc1)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	145966485	171129	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	9	2	6	3.9	CCc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4212664	171129	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	9	2	6	3.9	CCc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	1051	8237	63	None	-14	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/acsmedchemlett.6b00025
	4289	8237	63	None	-14	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/acsmedchemlett.6b00025
	445580	8237	63	None	-14	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/acsmedchemlett.6b00025
	57417355	8237	63	None	-14	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/acsmedchemlett.6b00025
	CHEMBL367149	8237	63	None	-14	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/acsmedchemlett.6b00025
	DB03756	8237	63	None	-14	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR40 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/acsmedchemlett.6b00025
	127030730	145592	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	395	6	1	5	5.0	Cc1cccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)c1	10.1016/j.ejmech.2016.02.040
	CHEMBL3781145	145592	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	395	6	1	5	5.0	Cc1cccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)c1	10.1016/j.ejmech.2016.02.040
	90151568	164350	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	489	7	1	5	5.5	CCc1cccc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4080516	164350	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	489	7	1	5	5.5	CCc1cccc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	137633536	163074	0	None	-173	6	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	163074	0	None	-173	6	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	46231549	207276	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	333	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3ccccc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL598674	207276	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	333	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3ccccc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	91809187	153902	13	None	-3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1016/j.bmcl.2016.10.074
	CHEMBL3927519	153902	13	None	-3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1016/j.bmcl.2016.10.074
	127050768	147067	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3cccc(F)c3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805903	147067	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3cccc(F)c3)s2)cc1	10.1016/j.bmc.2016.04.065
	131986116	170603	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	600	12	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206318	170603	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	600	12	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	58173002	129448	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.3	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1F	10.1016/j.bmc.2015.07.028
	CHEMBL3604037	129448	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.3	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1F	10.1016/j.bmc.2015.07.028
	122185439	129459	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	334	8	1	3	4.5	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604047	129459	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	334	8	1	3	4.5	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2015.07.028
	45107317	129473	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	354	8	1	3	4.9	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(CC)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604061	129473	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	354	8	1	3	4.9	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(CC)cccc32)cc1	10.1016/j.bmc.2015.07.028
	122185451	129474	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.4	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C(C)C)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604062	129474	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.4	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C(C)C)cccc32)cc1	10.1016/j.bmc.2015.07.028
	127046961	146835	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	383	7	1	4	5.0	Cc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3800362	146835	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	383	7	1	4	5.0	Cc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	90479828	189863	10	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	614	12	1	7	6.8	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4794409	189863	10	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	614	12	1	7	6.8	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)CC2)c1	10.1021/acs.jmedchem.0c00843
	57413288	82598	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2048614	82598	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
	51357276	188786	0	None	-10	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4780641	188786	0	None	-10	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	68194127	189974	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4795763	189974	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	52936292	188889	27	None	-7	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4782004	188889	27	None	-7	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	131986179	171576	0	None	1	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	532	7	1	5	7.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218348	171576	0	None	1	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	532	7	1	5	7.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	11245322	83917	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	359	7	2	3	5.3	O=C(O)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL207753	83917	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	359	7	2	3	5.3	O=C(O)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	162646017	186251	0	None	5	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4740846	186251	0	None	5	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	11773976	81556	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	400	8	2	3	5.7	CC(C)NC(=O)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL203126	81556	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	400	8	2	3	5.7	CC(C)NC(=O)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	46941175	68586	26	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773261	68586	26	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	44409878	147637	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	419	7	2	4	5.2	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CCC(N)=O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL381958	147637	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	419	7	2	4	5.2	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CCC(N)=O)cc1	10.1016/j.bmcl.2006.01.007
	51350270	65613	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/jm101405t
	CHEMBL1688463	65613	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/jm101405t
	51350274	65633	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3F)c2)cc1	10.1021/jm101405t
	CHEMBL1688483	65633	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3F)c2)cc1	10.1021/jm101405t
	57705851	170563	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	522	10	1	3	8.5	CC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1F	10.1021/acsmedchemlett.8b00213
	CHEMBL4205882	170563	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	522	10	1	3	8.5	CC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1F	10.1021/acsmedchemlett.8b00213
	155516879	176878	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	446	7	1	4	5.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(F)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4443509	176878	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	446	7	1	4	5.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(F)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	155522406	177405	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	456	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4c(C)cccc4C)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4451050	177405	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	456	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4c(C)cccc4C)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	46231597	206974	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	352	4	1	5	3.9	Cc1cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc(C)c1C#N	10.1016/j.bmcl.2009.10.052
	CHEMBL596667	206974	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	352	4	1	5	3.9	Cc1cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc(C)c1C#N	10.1016/j.bmcl.2009.10.052
	57398937	76789	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	340	8	1	3	4.8	COc1ccc(COc2ccc(C(C=C(C)C)CC(=O)O)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939641	76789	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	340	8	1	3	4.8	COc1ccc(COc2ccc(C(C=C(C)C)CC(=O)O)cc2)cc1	10.1016/j.bmcl.2011.10.118
	122185450	129472	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	341	7	1	5	4.5	CCO[C@@H](CC(=O)O)c1ccc(Oc2noc3c(C)cccc23)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604060	129472	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	341	7	1	5	4.5	CCO[C@@H](CC(=O)O)c1ccc(Oc2noc3c(C)cccc23)cc1	10.1016/j.bmc.2015.07.028
	90644298	118742	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	391	8	1	4	4.6	COC(Cc1ccc(OCc2cccc(-c3c(C)cccc3C)c2)nc1)C(=O)O	10.1016/j.bmcl.2014.04.065
	CHEMBL3288356	118742	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	391	8	1	4	4.6	COC(Cc1ccc(OCc2cccc(-c3c(C)cccc3C)c2)nc1)C(=O)O	10.1016/j.bmcl.2014.04.065
	121294346	186903	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	617	13	1	7	6.6	COCC(CC(=O)O)c1cccc(OCC2CCN(c3cc(OC)ccc3C(=O)N(CC(C)(C)C)c3cccc(C)n3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4748658	186903	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	617	13	1	7	6.6	COCC(CC(=O)O)c1cccc(OCC2CCN(c3cc(OC)ccc3C(=O)N(CC(C)(C)C)c3cccc(C)n3)CC2)c1	10.1021/acs.jmedchem.0c00843
	146314488	187920	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	451	10	1	4	6.1	COc1ccc(C(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4760668	187920	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	451	10	1	4	6.1	COc1ccc(C(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	67085761	163804	0	None	12	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	485	8	1	4	6.6	Cc1cc(OCc2ccccc2)ccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4073525	163804	0	None	12	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	485	8	1	4	6.6	Cc1cc(OCc2ccccc2)ccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	58218640	165701	0	None	15	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2CC[C@H](C)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4095599	165701	0	None	15	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2CC[C@H](C)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	145979171	173306	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	366	6	1	4	3.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(C)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4279126	173306	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	366	6	1	4	3.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(C)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	54757737	72121	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	283	3	1	2	2.9	Cc1c(C#Cc2ccc(CCC(=O)O)cc2)ccnc1F	10.1021/jm2005699
	CHEMBL1829165	72121	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	283	3	1	2	2.9	Cc1c(C#Cc2ccc(CCC(=O)O)cc2)ccnc1F	10.1021/jm2005699
	51350273	65632	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	362	8	1	3	5.0	COc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1688482	65632	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	362	8	1	3	5.0	COc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	71613094	96762	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381298	96762	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	75511307	129244	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	358	7	1	5	4.0	O=C(O)CCc1ccc(OCc2nc(-c3ccccc3Cl)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601008	129244	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	358	7	1	5	4.0	O=C(O)CCc1ccc(OCc2nc(-c3ccccc3Cl)no2)cc1	10.1016/j.bmcl.2015.06.018
	71460190	87439	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	380	8	1	3	5.1	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2)c1	10.1021/ml300133f
	CHEMBL2151292	87439	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	380	8	1	3	5.1	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2)c1	10.1021/ml300133f
	71454737	87450	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	512	9	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)c4ccccc4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151302	87450	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	512	9	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)c4ccccc4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	1050	8683	94	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	11595431	8683	94	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	CHEMBL207881	8683	94	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	57391958	76790	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	326	7	1	3	4.5	COc1ccc(COc2ccc(C(CC(=O)O)=C(C)C)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939642	76790	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	326	7	1	3	4.5	COc1ccc(COc2ccc(C(CC(=O)O)=C(C)C)cc2)cc1	10.1016/j.bmcl.2011.10.118
	57391960	76799	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939651	76799	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2011.10.118
	130253300	165890	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	428	7	1	5	4.3	COc1ccc(F)c(N2CCC(Oc3ccc(N4CCC[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4097617	165890	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	428	7	1	5	4.3	COc1ccc(F)c(N2CCC(Oc3ccc(N4CCC[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	137659366	166210	0	None	-1	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4101071	166210	0	None	-1	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
	145946817	174372	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CCN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4248694	174372	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CCN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4300846	174372	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CCN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	118642390	169463	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4170346	169463	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	142738575	169764	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	283	4	2	1	4.0	O=C(O)CCc1ccc2[nH]c(-c3ccccc3F)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4175260	169764	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	283	4	2	1	4.0	O=C(O)CCc1ccc2[nH]c(-c3ccccc3F)cc2c1	10.1021/acsmedchemlett.7b00460
	46231546	207386	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c(C)c1	10.1016/j.bmcl.2009.10.052
	CHEMBL599280	207386	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c(C)c1	10.1016/j.bmcl.2009.10.052
	118719473	122313	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	498	12	1	6	4.8	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)cc2)c1	10.1016/j.bmc.2014.11.016
	CHEMBL3353261	122313	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	498	12	1	6	4.8	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)cc2)c1	10.1016/j.bmc.2014.11.016
	122189682	130136	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	375	7	2	4	3.6	CC(C)(C)c1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616662	130136	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	375	7	2	4	3.6	CC(C)(C)c1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	137642174	167997	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	625	13	1	7	6.7	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3nc(C5CC5)nc5c3CCC5)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4091100	167997	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	625	13	1	7	6.7	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3nc(C5CC5)nc5c3CCC5)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4117940	167997	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	625	13	1	7	6.7	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3nc(C5CC5)nc5c3CCC5)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	90372616	149011	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	71615467	96765	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	538	9	1	7	4.9	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(C2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381301	96765	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	538	9	1	7	4.9	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(C2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	1646307	101778	12	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	385	7	1	4	4.7	O=C(O)CCCCCN1C(=O)/C(=C\c2cccc3ccccc23)SC1=S	10.1021/jm7012425
	CHEMBL254859	101778	12	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	385	7	1	4	4.7	O=C(O)CCCCCN1C(=O)/C(=C\c2cccc3ccccc23)SC1=S	10.1021/jm7012425
	118623088	148905	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883407	148905	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	134130352	148923	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883532	148923	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	58319098	93317	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	278	3	1	1	3.7	Cc1ccc(C)c(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315541	93317	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	278	3	1	1	3.7	Cc1ccc(C)c(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	145976935	170690	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	434	7	1	4	6.2	COc1cc(C)c(-c2cccc(COc3ccc4c(c3)SCC4CC(=O)O)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4207283	170690	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	434	7	1	4	6.2	COc1cc(C)c(-c2cccc(COc3ccc4c(c3)SCC4CC(=O)O)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	127029851	145640	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	411	7	1	6	4.7	COc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2016.02.040
	CHEMBL3781779	145640	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	411	7	1	6	4.7	COc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2016.02.040
	24825489	94098	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	317	6	2	2	4.6	O=C(O)Cc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL233223	94098	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	317	6	2	2	4.6	O=C(O)Cc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	46231485	207095	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	4	1	4	3.7	Cc1ccccc1Oc1ccc(CC2SC(=O)NC2=O)cc1	10.1016/j.bmcl.2009.10.052
	CHEMBL597436	207095	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	4	1	4	3.7	Cc1ccccc1Oc1ccc(CC2SC(=O)NC2=O)cc1	10.1016/j.bmcl.2009.10.052
	53248848	68942	0	None	2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777876	68942	0	None	2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	54580625	68939	0	None	1	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	272	5	1	2	3.6	CC#CC(CC(=O)O)c1ccc(OC2CCCC2)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777873	68939	0	None	1	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	272	5	1	2	3.6	CC#CC(CC(=O)O)c1ccc(OC2CCCC2)cc1	10.1016/j.bmcl.2011.03.114
	54586485	68931	0	None	-2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	398	5	1	2	6.2	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777865	68931	0	None	-2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	398	5	1	2	6.2	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	71615470	96768	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	576	9	1	7	5.4	CS(=O)(=O)CCCOc1ccc(-c2cc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)ccc2F)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381304	96768	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	576	9	1	7	5.4	CS(=O)(=O)CCCOc1ccc(-c2cc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)ccc2F)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	145976845	170510	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	484	11	1	6	4.4	COCCOc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4205241	170510	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	484	11	1	6	4.4	COCCOc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	54583099	68585	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	345	7	2	2	5.3	Cc1ccc(-c2cccc(CNc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/ml100106c
	CHEMBL1773260	68585	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	345	7	2	2	5.3	Cc1ccc(-c2cccc(CNc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/ml100106c
	44409699	147121	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	361	8	2	3	5.7	CC(CC(=O)O)c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL380719	147121	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	361	8	2	3	5.7	CC(CC(=O)O)c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	134130859	148961	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	416	6	1	2	6.9	CC1(C)CCC=C1c1cccc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883983	148961	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	416	6	1	2	6.9	CC1(C)CCC=C1c1cccc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)c1	10.1021/acsmedchemlett.6b00443
	24825505	155054	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	285	7	2	3	3.3	COc1ccc(CNc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL393661	155054	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	285	7	2	3	3.3	COc1ccc(CNc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2006.12.084
	10131213	186108	3	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	252	3	1	2	2.6	O=C(O)COc1ccc(C#Cc2ccccc2)cc1	10.1021/jm8010178
	CHEMBL473459	186108	3	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	252	3	1	2	2.6	O=C(O)COc1ccc(C#Cc2ccccc2)cc1	10.1021/jm8010178
	137633536	163074	0	None	-173	6	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	163074	0	None	-173	6	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	137647721	164609	0	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	164609	0	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	82051616	166236	1	None	-12	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	166236	1	None	-12	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	54584097	68575	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	382	6	1	2	3.9	O=C(O)CCc1ccc(OCc2ccccc2)c(I)c1	10.1021/ml100106c
	CHEMBL1773250	68575	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	382	6	1	2	3.9	O=C(O)CCc1ccc(OCc2ccccc2)c(I)c1	10.1021/ml100106c
	75511312	129281	3	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	402	7	1	5	4.1	O=C(O)CCc1ccc(OCc2nc(-c3cccc(Br)c3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601049	129281	3	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	402	7	1	5	4.1	O=C(O)CCc1ccc(OCc2nc(-c3cccc(Br)c3)no2)cc1	10.1016/j.bmcl.2015.06.018
	137629014	167764	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	585	12	1	7	5.8	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ncnc5c3CCC5)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4063785	167764	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	585	12	1	7	5.8	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ncnc5c3CCC5)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116078	167764	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	585	12	1	7	5.8	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ncnc5c3CCC5)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	54580624	68926	0	None	-2	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	362	5	1	2	5.4	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2C)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777860	68926	0	None	-2	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	362	5	1	2	5.4	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2C)cc1	10.1016/j.bmcl.2011.03.114
	118623101	174368	0	None	-12	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159416	174368	0	None	-12	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300796	174368	0	None	-12	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	118642344	148900	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883380	148900	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	91801188	176354	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4435837	176354	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c1	10.1016/j.bmcl.2019.04.050
	134151755	161230	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	581	10	1	4	7.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccc(C(F)(F)F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3976110	161230	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	581	10	1	4	7.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccc(C(F)(F)F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990146	161230	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	581	10	1	4	7.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccc(C(F)(F)F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	137630599	167872	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	559	12	1	7	5.6	Cc1nccnc1OCCC1CCOC2(CCN(Cc3ccc(COc4ccc(CCC(=O)O)cc4)cc3)CC2)C1	10.1016/j.ejmech.2017.01.005
	CHEMBL4072869	167872	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	559	12	1	7	5.6	Cc1nccnc1OCCC1CCOC2(CCN(Cc3ccc(COc4ccc(CCC(=O)O)cc4)cc3)CC2)C1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116895	167872	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	559	12	1	7	5.6	Cc1nccnc1OCCC1CCOC2(CCN(Cc3ccc(COc4ccc(CCC(=O)O)cc4)cc3)CC2)C1	10.1016/j.ejmech.2017.01.005
	131986090	171071	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	8	1	7	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(S(C)(=O)=O)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4212041	171071	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	8	1	7	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(S(C)(=O)=O)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	145967994	171567	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	399	7	1	5	3.5	Cc1ccc(C)n1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4218236	171567	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	399	7	1	5	3.5	Cc1ccc(C)n1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	127048827	147061	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	371	6	2	5	3.6	O=C(O)CCc1nnc(C(=O)Nc2cccc(-c3ccc(F)cc3)c2)s1	10.1016/j.bmc.2016.04.065
	CHEMBL3805879	147061	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	371	6	2	5	3.6	O=C(O)CCc1nnc(C(=O)Nc2cccc(-c3ccc(F)cc3)c2)s1	10.1016/j.bmc.2016.04.065
	142738582	191299	0	None	42	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4847662	191299	0	None	42	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	46854655	7183	47	None	-8	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.ejmech.2018.09.071
	6485	7183	47	None	-8	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.ejmech.2018.09.071
	CHEMBL1829173	7183	47	None	-8	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.ejmech.2018.09.071
	46854655	7183	47	None	-8	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) by calcium flux assayAgonist activity at GPR40 (unknown origin) by calcium flux assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2016.10.074
	6485	7183	47	None	-8	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) by calcium flux assayAgonist activity at GPR40 (unknown origin) by calcium flux assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2016.10.074
	CHEMBL1829173	7183	47	None	-8	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) by calcium flux assayAgonist activity at GPR40 (unknown origin) by calcium flux assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2016.10.074
	57706778	87572	29	None	-8	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml4005123
	CHEMBL2152070	87572	29	None	-8	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml4005123
	24857285	82394	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	566	9	2	7	4.8	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047157	82394	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	566	9	2	7	4.8	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	131986027	170717	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	606	11	1	7	7.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4207592	170717	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	606	11	1	7	7.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986061	170895	0	None	-6	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	518	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4209834	170895	0	None	-6	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	518	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	67058307	129412	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3cc(C(F)(F)F)ccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3603843	129412	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3cc(C(F)(F)F)ccc32)cc1	10.1016/j.bmc.2015.07.028
	67058222	129464	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(F)c3ccccc23)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604052	129464	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(F)c3ccccc23)cc1	10.1016/j.bmc.2015.07.028
	122185447	129469	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2F)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604057	129469	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2F)cc1	10.1016/j.bmc.2015.07.028
	45107324	129475	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	366	8	1	3	5.2	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C4CC4)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604063	129475	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	366	8	1	3	5.2	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C4CC4)cccc32)cc1	10.1016/j.bmc.2015.07.028
	1050	8683	94	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.04.065
	11595431	8683	94	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.04.065
	CHEMBL207881	8683	94	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.04.065
	134138870	154450	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assay	ChEMBL	491	9	2	5	5.2	Cc1cc(OCCC(C)O)cc(C)c1-c1ccc(F)c(COc2cc3c(cn2)[C@@H]2C(C(=O)O)[C@@H]2C3)c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3931755	154450	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assay	ChEMBL	491	9	2	5	5.2	Cc1cc(OCCC(C)O)cc(C)c1-c1ccc(F)c(COc2cc3c(cn2)[C@@H]2C(C(=O)O)[C@@H]2C3)c1	10.1016/j.bmcl.2016.10.074
	57413290	82601	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	448	12	1	4	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2048617	82601	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	448	12	1	4	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
	46854655	7183	47	None	1	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2011.10.118
	6485	7183	47	None	1	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2011.10.118
	CHEMBL1829173	7183	47	None	1	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2011.10.118
	145947998	174495	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4171104	174495	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302546	174495	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	11245322	83917	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	359	7	2	3	5.3	O=C(O)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL207753	83917	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	359	7	2	3	5.3	O=C(O)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	71575419	96747	0	None	5	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381282	96747	0	None	5	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	54584572	68944	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777878	68944	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	90644292	118736	0	None	10	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288350	118736	0	None	10	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	145983698	173199	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	382	7	1	5	3.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(OC)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4277181	173199	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	382	7	1	5	3.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(OC)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	67087160	189123	0	None	-6	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4784555	189123	0	None	-6	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	90644293	118737	0	None	-13	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ncc1CCC(=O)O	10.1016/j.bmcl.2014.04.065
	CHEMBL3288351	118737	0	None	-13	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ncc1CCC(=O)O	10.1016/j.bmcl.2014.04.065
	90644301	118745	0	None	-9	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	405	9	1	4	5.5	CCOC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)nc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288359	118745	0	None	-9	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	405	9	1	4	5.5	CCOC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)nc1	10.1016/j.bmcl.2014.04.065
	57706778	87572	29	None	-8	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL2152070	87572	29	None	-8	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	57706778	87572	29	None	-8	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL2152070	87572	29	None	-8	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2019.04.050
	134157016	161216	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	547	11	1	5	6.2	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3cccc(F)c3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3985181	161216	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	547	11	1	5	6.2	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3cccc(F)c3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990065	161216	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	547	11	1	5	6.2	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3cccc(F)c3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	137655619	165477	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	340	6	1	4	4.0	CN(C)c1cccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4093180	165477	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	340	6	1	4	4.0	CN(C)c1cccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01559
	87265393	166060	0	None	-4	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	5	1	3	5.7	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2C(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4099410	166060	0	None	-4	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	5	1	3	5.7	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2C(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	58218699	166195	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	373	6	1	3	5.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4100898	166195	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	373	6	1	3	5.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
	137631654	163079	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	449	8	1	5	5.7	O=C(O)CCc1ccc(-c2ccc3c(OCc4ccccc4)nn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4065429	163079	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	449	8	1	5	5.7	O=C(O)CCc1ccc(-c2ccc3c(OCc4ccccc4)nn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	137641734	164821	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	6	1	3	4.6	O=C(O)C[C@H]1CCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4085805	164821	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	6	1	3	4.6	O=C(O)C[C@H]1CCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	142738556	169547	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	333	4	2	1	4.9	O=C(O)CCc1ccc2[nH]c(-c3ccccc3C(F)(F)F)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4171817	169547	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	333	4	2	1	4.9	O=C(O)CCc1ccc2[nH]c(-c3ccccc3C(F)(F)F)cc2c1	10.1021/acsmedchemlett.7b00460
	71458348	87448	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	504	9	1	3	8.1	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCCC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151300	87448	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	504	9	1	3	8.1	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCCC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	75511315	129290	4	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	358	7	1	5	4.0	O=C(O)CCc1ccc(OCc2nc(-c3ccccc3)no2)c(Cl)c1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601058	129290	4	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	358	7	1	5	4.0	O=C(O)CCc1ccc(OCc2nc(-c3ccccc3)no2)c(Cl)c1	10.1016/j.bmcl.2015.06.018
	137647721	164609	0	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	164609	0	None	-1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	44634022	72098	1	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccn2)cc1	10.1021/jm2005699
	CHEMBL1829143	72098	1	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccn2)cc1	10.1021/jm2005699
	71615671	96780	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1cc(C)cc(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381316	96780	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1cc(C)cc(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c1	10.1016/j.bmcl.2013.03.060
	122189737	130170	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	361	7	2	4	3.3	Cc1ccc(OC(C)C(=O)Nc2ccc(OCC(=O)O)c(F)c2)cc1C	10.1016/j.bmc.2015.09.010
	CHEMBL3616719	130170	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	361	7	2	4	3.3	Cc1ccc(OC(C)C(=O)Nc2ccc(OCC(=O)O)c(F)c2)cc1C	10.1016/j.bmc.2015.09.010
	145956160	169275	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	522	8	1	5	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(Cl)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4167397	169275	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	522	8	1	5	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(Cl)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	145972020	169904	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	457	8	2	4	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)NC3CCCc4ccccc43)o2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4177506	169904	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	457	8	2	4	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)NC3CCCc4ccccc43)o2)cc1	10.1016/j.ejmech.2018.04.023
	118637974	168817	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	398	6	1	2	6.4	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3ccccc3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	CHEMBL4160127	168817	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	398	6	1	2	6.4	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3ccccc3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	131986164	171398	0	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4216016	171398	0	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	51049992	152397	5	None	-23	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL3915620	152397	5	None	-23	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	54757738	72122	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	299	3	1	2	3.5	Cc1c(C#Cc2ccc(CCC(=O)O)cc2)ccnc1Cl	10.1021/jm2005699
	CHEMBL1829166	72122	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	299	3	1	2	3.5	Cc1c(C#Cc2ccc(CCC(=O)O)cc2)ccnc1Cl	10.1021/jm2005699
	23136411	65606	0	None	11	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/ml100106c
	CHEMBL1688457	65606	0	None	11	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/ml100106c
	90151518	163693	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	489	6	1	5	5.6	Cc1cccc(C)c1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	CHEMBL4072314	163693	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	489	6	1	5	5.6	Cc1cccc(C)c1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	46231598	208978	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	349	4	1	4	4.5	O=C1NC(=O)C(Cc2ccc(Oc3cccc4ccccc34)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL609615	208978	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	349	4	1	4	4.5	O=C1NC(=O)C(Cc2ccc(Oc3cccc4ccccc34)cc2)S1	10.1016/j.bmcl.2009.10.052
	122189672	130131	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	333	7	2	4	2.7	CC(Oc1ccccc1)C(=O)Nc1ccc(OCC(=O)O)c(F)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616652	130131	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	333	7	2	4	2.7	CC(Oc1ccccc1)C(=O)Nc1ccc(OCC(=O)O)c(F)c1	10.1016/j.bmc.2015.09.010
	122189676	130132	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	351	7	2	4	2.8	CC(Oc1ccccc1F)C(=O)Nc1ccc(OCC(=O)O)c(F)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616656	130132	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	351	7	2	4	2.8	CC(Oc1ccccc1F)C(=O)Nc1ccc(OCC(=O)O)c(F)c1	10.1016/j.bmc.2015.09.010
	134149615	155355	0	None	-23	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	155355	0	None	-23	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	145973937	171365	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	487	10	2	6	5.2	COc1ccc(C(Cc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c2ccccc2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4215600	171365	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	487	10	2	6	5.2	COc1ccc(C(Cc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c2ccccc2)cc1	10.1016/j.ejmech.2017.09.019
	145980455	173491	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	365	6	2	4	3.7	O=C(O)CCc1ccc(NCC2COc3ccc(Cl)cc3O2)cc1F	10.1016/j.bmc.2018.10.019
	CHEMBL4282779	173491	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	365	6	2	4	3.7	O=C(O)CCc1ccc(NCC2COc3ccc(Cl)cc3O2)cc1F	10.1016/j.bmc.2018.10.019
	20993091	68922	11	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	310	5	1	2	4.8	O=C(O)CCc1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777856	68922	11	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	310	5	1	2	4.8	O=C(O)CCc1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	54584572	68944	0	None	1	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777878	68944	0	None	1	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	134149615	155355	0	None	-23	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	155355	0	None	-23	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	127033820	145556	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	415	6	1	5	5.3	Cc1nc(-c2cccc(Cl)c2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	CHEMBL3780713	145556	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	415	6	1	5	5.3	Cc1nc(-c2cccc(Cl)c2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	118637996	148948	0	None	-15	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883819	148948	0	None	-15	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4162778	148948	0	None	-15	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	145949955	169689	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	489	8	1	6	4.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccn4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4173953	169689	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	489	8	1	6	4.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccn4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	71562317	93314	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	Cc1ccccc1C#Cc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315538	93314	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	Cc1ccccc1C#Cc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1021/jm301470a
	71562423	93319	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	298	3	1	1	4.1	Cc1cc(Cl)ccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315543	93319	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	298	3	1	1	4.1	Cc1cc(Cl)ccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	145972304	171323	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	423	8	2	6	3.9	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3ccc4c(c3)CCC4)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4215103	171323	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	423	8	2	6	3.9	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3ccc4c(c3)CCC4)s2)cc1	10.1016/j.ejmech.2017.09.019
	118637996	148948	0	None	-15	2	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883819	148948	0	None	-15	2	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL4162778	148948	0	None	-15	2	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	46231843	207284	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	432	5	1	6	4.4	COc1cc(Oc2ncc(C(F)(F)F)cc2Cl)ccc1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	CHEMBL598732	207284	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	432	5	1	6	4.4	COc1cc(Oc2ncc(C(F)(F)F)cc2Cl)ccc1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	134130352	148923	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883532	148923	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	134143899	157018	0	None	-4	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	157018	0	None	-4	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	24857286	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	6484	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	CHEMBL1829174	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	DB12491	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	146948845	192659	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	522	11	1	5	5.5	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CCc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4868224	192659	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	522	11	1	5	5.5	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CCc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/acs.jmedchem.1c00031
	57414539	82395	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	524	11	1	6	5.3	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	CHEMBL2047158	82395	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	524	11	1	6	5.3	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	24857286	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.7b00460
	6484	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.7b00460
	CHEMBL1829174	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.7b00460
	DB12491	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.7b00460
	24857286	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
	6484	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
	CHEMBL1829174	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
	DB12491	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
	90644301	118745	0	None	9	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	405	9	1	4	5.5	CCOC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)nc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288359	118745	0	None	9	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	405	9	1	4	5.5	CCOC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)nc1	10.1016/j.bmcl.2014.04.065
	11190525	82600	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	466	10	1	3	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
	CHEMBL2048616	82600	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	466	10	1	3	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
	162667620	189336	0	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	CHEMBL4787628	189336	0	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	162644059	188603	0	None	45	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
	CHEMBL4778264	188603	0	None	45	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
	67087100	189377	0	None	-11	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4788206	189377	0	None	-11	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	145952952	169270	0	None	1	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4167323	169270	0	None	1	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	131986027	170717	0	None	-1	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	606	11	1	7	7.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4207592	170717	0	None	-1	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	606	11	1	7	7.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986112	171196	0	None	3	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccc(OCCOC)c4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4213548	171196	0	None	3	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccc(OCCOC)c4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986072	171231	0	None	1	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4213937	171231	0	None	1	2	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	134131511	148936	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883627	148936	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	24857286	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm2005699
	6484	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm2005699
	CHEMBL1829174	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm2005699
	DB12491	8405	72	None	-3	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm2005699
	44409843	147183	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	473	7	2	4	6.4	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC(C)C)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL380884	147183	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	473	7	2	4	6.4	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC(C)C)cc1	10.1016/j.bmcl.2006.01.007
	51350138	65623	0	None	660	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL1688473	65623	0	None	660	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	46941175	68586	26	None	-1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albumin	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1773261	68586	26	None	-1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albumin	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	60195037	88497	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA	ChEMBL	495	12	2	5	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL2163925	88497	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA	ChEMBL	495	12	2	5	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	44409676	81778	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	374	7	3	4	4.7	O=C(NO)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL203297	81778	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	374	7	3	4	4.7	O=C(NO)[C@H]1C[C@@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	57705749	171631	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4218995	171631	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	121294749	189520	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	542	11	1	5	6.2	COc1ccc(C(=O)N(C)c2ccccc2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4789994	189520	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	542	11	1	5	6.2	COc1ccc(C(=O)N(C)c2ccccc2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	58218607	162719	0	None	7	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2C[C@@H](C)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4061093	162719	0	None	7	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2C[C@@H](C)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	57325842	80881	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	474	10	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(C(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022580	80881	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	474	10	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(C(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	58230598	189898	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
	CHEMBL4794904	189898	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
	122189683	130137	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	389	7	2	4	4.0	CC(Oc1cccc(C(C)(C)C)c1)C(=O)Nc1ccc(OCC(=O)O)c(F)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616663	130137	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	389	7	2	4	4.0	CC(Oc1cccc(C(C)(C)C)c1)C(=O)Nc1ccc(OCC(=O)O)c(F)c1	10.1016/j.bmc.2015.09.010
	137649555	164109	0	None	-2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4077507	164109	0	None	-2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	90644292	118736	0	None	-10	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288350	118736	0	None	-10	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	137658391	166427	0	None	-1	2	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	6	1	3	5.3	Cc1cc(OCc2ccc(Cl)cc2Cl)ccc1N1CCC[C@H]1CC(=O)O	10.1021/acs.jmedchem.6b01559
	CHEMBL4103681	166427	0	None	-1	2	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	6	1	3	5.3	Cc1cc(OCc2ccc(Cl)cc2Cl)ccc1N1CCC[C@H]1CC(=O)O	10.1021/acs.jmedchem.6b01559
	54586485	68931	0	None	2	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	398	5	1	2	6.2	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777865	68931	0	None	2	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	398	5	1	2	6.2	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	46231842	207283	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	397	5	1	5	4.7	COc1cc(Oc2ccc(Cl)cc2Cl)ccc1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	CHEMBL598731	207283	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	397	5	1	5	4.7	COc1cc(Oc2ccc(Cl)cc2Cl)ccc1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	66562389	97142	0	None	58	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	CHEMBL2386360	97142	0	None	58	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	145965968	171025	0	None	-4	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	480	7	1	5	6.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3c(c2)c(-c2ccccc2C)c[s+]3[O-])cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4211335	171025	0	None	-4	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	480	7	1	5	6.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3c(c2)c(-c2ccccc2C)c[s+]3[O-])cc1	10.1016/j.bmcl.2017.12.022
	137656526	166532	0	None	-2	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	166532	0	None	-2	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	127046662	146818	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	441	10	1	5	5.7	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OCC(C)C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3800255	146818	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	441	10	1	5	5.7	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OCC(C)C)c1	10.1016/j.ejmech.2016.03.054
	46231779	207657	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	350	4	1	5	3.9	O=C1NC(=O)C(Cc2ccc(Oc3cc4ccccc4cn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL601420	207657	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	350	4	1	5	3.9	O=C1NC(=O)C(Cc2ccc(Oc3cc4ccccc4cn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	145962064	169016	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	474	8	2	5	5.1	CC#CC(CC(=O)O)c1ccc(OCc2cnc(C(=O)NC3CCCc4ccccc43)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4163436	169016	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	474	8	2	5	5.1	CC#CC(CC(=O)O)c1ccc(OCc2cnc(C(=O)NC3CCCc4ccccc43)s2)cc1	10.1016/j.ejmech.2018.04.023
	71562316	93313	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	262	2	1	1	3.3	O=C(O)[C@H]1C[C@@H]1c1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	CHEMBL2315537	93313	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	262	2	1	1	3.3	O=C(O)[C@H]1C[C@@H]1c1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	66562390	97140	0	None	39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
	CHEMBL2386358	97140	0	None	39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
	44409929	83200	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	345	7	2	3	5.2	O=C(O)/C=C/c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL205960	83200	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	345	7	2	3	5.2	O=C(O)/C=C/c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	127033352	145798	0	None	2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785789	145798	0	None	2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	66562387	97148	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386366	97148	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	71613096	96764	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	558	9	1	7	5.3	CS(=O)(=O)CCCOc1ccc(-c2cccc([C@H]3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381300	96764	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	558	9	1	7	5.3	CS(=O)(=O)CCCOc1ccc(-c2cccc([C@H]3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	168278906	197810	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	438	10	1	4	5.9	Cc1ccc(OCC(C)C)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5186963	197810	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	438	10	1	4	5.9	Cc1ccc(OCC(C)C)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	2214962	101435	8	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	283	7	2	3	3.6	C=CCOc1ccc(CNc2cccc(C(=O)O)c2)cc1	10.1021/jm7012425
	CHEMBL252528	101435	8	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	283	7	2	3	3.6	C=CCOc1ccc(CNc2cccc(C(=O)O)c2)cc1	10.1021/jm7012425
	91824140	157855	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	425	7	1	5	4.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(-c3ccccc3C)cn3ncnc23)cc1	10.1016/j.bmcl.2016.10.074
	CHEMBL3958983	157855	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	425	7	1	5	4.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(-c3ccccc3C)cn3ncnc23)cc1	10.1016/j.bmcl.2016.10.074
	118623101	174368	0	None	-12	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159416	174368	0	None	-12	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300796	174368	0	None	-12	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	90357232	149030	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884803	149030	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	122185446	129468	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1cccc(OCc2ccc(Cl)c(Cl)c2)c1	10.1016/j.bmc.2015.07.028
	CHEMBL3604056	129468	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1cccc(OCc2ccc(Cl)c(Cl)c2)c1	10.1016/j.bmc.2015.07.028
	122189685	130107	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	349	8	2	5	2.3	COc1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3616479	130107	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	349	8	2	5	2.3	COc1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	6483	10658	54	None	-13	4	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assayAgonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66553168	10658	54	None	-13	4	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assayAgonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	CHEMBL2386353	10658	54	None	-13	4	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assayAgonist activity at mouse FFA1 receptor transfected in human T-REX-293 cells measured for 74 secs by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	145987974	173857	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	362	7	1	5	3.1	COc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CO2	10.1016/j.bmc.2018.10.019
	CHEMBL4289597	173857	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	362	7	1	5	3.1	COc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CO2	10.1016/j.bmc.2018.10.019
	137655393	165513	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	351	7	1	5	3.6	Cc1cccc(C)c1-c1cccc(OCc2cn(CCC(=O)O)nn2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4093521	165513	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	351	7	1	5	3.6	Cc1cccc(C)c1-c1cccc(OCc2cn(CCC(=O)O)nn2)c1	10.1021/acs.jmedchem.6b01357
	137529979	170954	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	473	6	3	4	5.2	CNC(=O)c1cc(C)c(-c2ccc(F)c3c2CC[C@H]3Nc2ccc([C@H]3C[C@@H]3C(=O)O)nc2)c(C)c1	10.1021/acsmedchemlett.8b00343
	CHEMBL4210588	170954	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	473	6	3	4	5.2	CNC(=O)c1cc(C)c(-c2ccc(F)c3c2CC[C@H]3Nc2ccc([C@H]3C[C@@H]3C(=O)O)nc2)c(C)c1	10.1021/acsmedchemlett.8b00343
	122189678	130134	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	333	7	2	4	2.6	Cc1ccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)cc1	10.1016/j.bmc.2015.09.010
	CHEMBL3616658	130134	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	333	7	2	4	2.6	Cc1ccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)cc1	10.1016/j.bmc.2015.09.010
	137629795	167962	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	545	12	1	7	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3cnccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4063221	167962	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	545	12	1	7	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3cnccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4117645	167962	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	545	12	1	7	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3cnccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	137633561	163130	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	351	7	1	5	3.6	Cc1cccc(C)c1-c1cccc(COc2cn(CCC(=O)O)nn2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4065921	163130	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	351	7	1	5	3.6	Cc1cccc(C)c1-c1cccc(COc2cn(CCC(=O)O)nn2)c1	10.1021/acs.jmedchem.6b01357
	54582631	68933	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	360	5	1	4	3.6	CC#CC(CC(=O)O)c1ccc(Oc2ncc(Br)cn2)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777867	68933	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	360	5	1	4	3.6	CC#CC(CC(=O)O)c1ccc(Oc2ncc(Br)cn2)cc1	10.1016/j.bmcl.2011.03.114
	54581633	68935	0	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	331	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2nccc3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777869	68935	0	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	331	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2nccc3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	131986072	171231	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4213937	171231	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986179	171576	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	532	7	1	5	7.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218348	171576	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	532	7	1	5	7.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C(F)(F)F)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	57413289	82599	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	430	10	1	3	6.4	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
	CHEMBL2048615	82599	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	430	10	1	3	6.4	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
	11398822	82607	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	556	10	2	6	5.0	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL2048624	82607	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	556	10	2	6	5.0	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	46854655	7183	47	None	-8	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
	6485	7183	47	None	-8	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
	CHEMBL1829173	7183	47	None	-8	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
	118145140	182164	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cc3c(cn2)[C@H](Oc2cccc([C@H](C4CC4)[C@H](C)C(=O)O)c2)CC3)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4575265	182164	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cc3c(cn2)[C@H](Oc2cccc([C@H](C4CC4)[C@H](C)C(=O)O)c2)CC3)c1	10.1016/j.bmcl.2019.04.050
	145967748	170290	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	496	12	1	5	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4202452	170290	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	496	12	1	5	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	118645526	189759	0	None	-3	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	5.8	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2N2CC3(CCC3)C2)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4793322	189759	0	None	-3	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	5.8	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2N2CC3(CCC3)C2)c1	10.1016/j.bmcl.2018.01.013
	155569585	182988	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	419	7	2	3	5.6	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3C(F)(F)F)c2)cc1F	10.1016/j.ejmech.2019.06.087
	CHEMBL4593950	182988	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	419	7	2	3	5.6	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3C(F)(F)F)c2)cc1F	10.1016/j.ejmech.2019.06.087
	127047527	146650	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	403	7	1	4	5.3	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)ccc1Cl	10.1016/j.ejmech.2016.03.054
	CHEMBL3799274	146650	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	403	7	1	4	5.3	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)ccc1Cl	10.1016/j.ejmech.2016.03.054
	155527415	178003	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	453	7	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(C#N)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4459626	178003	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	453	7	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(C#N)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	57706778	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL2152070	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acs.jmedchem.0c00843
	162674275	189770	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	491	10	1	4	7.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4793427	189770	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	491	10	1	4	7.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1	10.1021/acs.jmedchem.0c00843
	58218740	163224	0	None	45	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	315	5	1	3	4.1	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2F)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4067052	163224	0	None	45	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	315	5	1	3	4.1	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2F)cc1	10.1021/acs.jmedchem.6b01559
	137646482	164530	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4082459	164530	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	58218551	165826	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	309	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4096887	165826	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	309	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	137633394	163203	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	541	8	1	6	5.4	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](F)C2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4066815	163203	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	541	8	1	6	5.4	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](F)C2)c1	10.1021/acs.jmedchem.7b00982
	90151501	165534	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	510	7	1	7	4.5	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c(F)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4093944	165534	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	510	7	1	7	4.5	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c(F)cn1	10.1021/acs.jmedchem.7b00982
	145980470	173515	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	420	6	1	4	4.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(Cl)c(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4283222	173515	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	420	6	1	4	4.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(Cl)c(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	156703595	198692	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	438	10	1	5	5.1	COc1ccc(/C=C/c2cc(OC)cc(OCc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.ejmech.2021.114061
	CHEMBL5200141	198692	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	438	10	1	5	5.1	COc1ccc(/C=C/c2cc(OC)cc(OCc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.ejmech.2021.114061
	58172971	129446	2	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	382	8	1	3	5.4	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(C)c1	10.1016/j.bmc.2015.07.028
	CHEMBL3604035	129446	2	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	382	8	1	3	5.4	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(C)c1	10.1016/j.bmc.2015.07.028
	67085761	163804	0	None	-12	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	485	8	1	4	6.6	Cc1cc(OCc2ccccc2)ccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4073525	163804	0	None	-12	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	485	8	1	4	6.6	Cc1cc(OCc2ccccc2)ccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	137651358	163922	0	None	-2	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4075162	163922	0	None	-2	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
	118144953	182427	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2ccc3c(n2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4581212	182427	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2ccc3c(n2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	58319121	93323	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	284	3	1	1	3.8	O=C(O)CCc1ccc(C#Cc2ccccc2Cl)cc1	10.1021/jm301470a
	CHEMBL2315547	93323	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	284	3	1	1	3.8	O=C(O)CCc1ccc(C#Cc2ccccc2Cl)cc1	10.1021/jm301470a
	1855223	101410	15	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	404	8	1	7	4.8	COc1ccc(CSc2nnc(SCc3ccc(C(=O)O)cc3)s2)cc1	10.1021/jm7012425
	CHEMBL252330	101410	15	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	404	8	1	7	4.8	COc1ccc(CSc2nnc(SCc3ccc(C(=O)O)cc3)s2)cc1	10.1021/jm7012425
	71257551	157372	24	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1016/j.bmcl.2016.10.074
	CHEMBL3955132	157372	24	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1016/j.bmcl.2016.10.074
	127051660	147045	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	397	8	2	6	3.7	Cc1ccccc1NC(=O)c1nnc(COc2ccc(CCC(=O)O)cc2)s1	10.1016/j.bmc.2016.04.065
	CHEMBL3805668	147045	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	397	8	2	6	3.7	Cc1ccccc1NC(=O)c1nnc(COc2ccc(CCC(=O)O)cc2)s1	10.1016/j.bmc.2016.04.065
	145975293	170365	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	397	8	2	6	3.7	Cc1ccccc1OCc1nnc(C(=O)Nc2ccc(CCC(=O)O)cc2)s1	10.1016/j.ejmech.2017.09.019
	CHEMBL4203402	170365	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	397	8	2	6	3.7	Cc1ccccc1OCc1nnc(C(=O)Nc2ccc(CCC(=O)O)cc2)s1	10.1016/j.ejmech.2017.09.019
	118719717	122440	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	512	12	1	6	5.1	Cc1cc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)ccc1OCC(=O)O	10.1016/j.bmc.2014.11.016
	CHEMBL3353738	122440	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	512	12	1	6	5.1	Cc1cc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)ccc1OCC(=O)O	10.1016/j.bmc.2014.11.016
	168276115	197052	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	450	10	1	4	6.0	Cc1ccc(OCC2CCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5175597	197052	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	450	10	1	4	6.0	Cc1ccc(OCC2CCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	145977707	170735	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	8	2	6	4.0	Cc1ccc(C)c(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.ejmech.2017.09.019
	CHEMBL4207787	170735	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	8	2	6	4.0	Cc1ccc(C)c(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.ejmech.2017.09.019
	90372616	149011	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	51349861	65603	0	None	77	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL1688454	65603	0	None	77	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	25150119	193165	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	274	3	1	1	3.1	C#Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL487570	193165	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	274	3	1	1	3.1	C#Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	137636167	162766	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	162766	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	145954794	169302	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	502	9	1	5	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4167766	169302	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	502	9	1	5	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	155561223	182461	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2cc3c(cc2F)[C@H](Oc2cccc([C@H](C4CC4)[C@H](C)C(=O)O)c2)CC3)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4581859	182461	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2cc3c(cc2F)[C@H](Oc2cccc([C@H](C4CC4)[C@H](C)C(=O)O)c2)CC3)c1	10.1016/j.bmcl.2019.04.050
	54582631	68933	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	360	5	1	4	3.6	CC#CC(CC(=O)O)c1ccc(Oc2ncc(Br)cn2)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777867	68933	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	360	5	1	4	3.6	CC#CC(CC(=O)O)c1ccc(Oc2ncc(Br)cn2)cc1	10.1016/j.bmcl.2011.03.114
	145968322	171799	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	380	6	1	4	5.3	Cc1ccsc1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4226029	171799	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	380	6	1	4	5.3	Cc1ccsc1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	145976267	170368	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	417	8	2	6	4.0	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3cccc(Cl)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4203431	170368	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	417	8	2	6	4.0	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3cccc(Cl)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	54583581	68934	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	307	5	1	5	2.7	CC#CC(CC(=O)O)c1ccc(Oc2nccnc2C#N)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777868	68934	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	307	5	1	5	2.7	CC#CC(CC(=O)O)c1ccc(Oc2nccnc2C#N)cc1	10.1016/j.bmcl.2011.03.114
	24825487	160057	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	345	8	2	2	5.4	O=C(O)CCCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL397776	160057	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	345	8	2	2	5.4	O=C(O)CCCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	137636167	162766	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	162766	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	137657972	166383	0	None	-40	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	166383	0	None	-40	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	137656526	166532	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	166532	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	24857286	8405	72	None	-3	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
	6484	8405	72	None	-3	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
	CHEMBL1829174	8405	72	None	-3	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
	DB12491	8405	72	None	-3	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
	57414267	82386	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	CHEMBL2047149	82386	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	23642299	82404	1	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	542	11	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047168	82404	1	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	542	11	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	24857375	82405	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	558	11	1	6	6.0	Cc1cc(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047169	82405	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	558	11	1	6	6.0	Cc1cc(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	131986051	170662	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	489	7	1	6	6.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C#N)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206968	170662	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	489	7	1	6	6.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C#N)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	155526793	177973	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	462	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(F)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4459220	177973	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	462	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(F)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	15603946	118435	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	501	8	1	6	6.1	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nccn2C)cc1	10.1021/ml400501x
	CHEMBL3286409	118435	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	501	8	1	6	6.1	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nccn2C)cc1	10.1021/ml400501x
	118129998	164102	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4077366	164102	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	71613518	96751	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1ccc(Cl)c(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381287	96751	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1ccc(Cl)c(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	131986147	171558	0	None	6	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	456	7	1	5	6.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCCC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218110	171558	0	None	6	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	456	7	1	5	6.4	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCCC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	90644290	118734	0	None	-4	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2cnc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288348	118734	0	None	-4	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2cnc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	118642384	148943	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883790	148943	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	155551584	180778	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	448	8	1	4	6.0	COc1ccc(F)c(-c2ccc3c(c2)OC[C@@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4542487	180778	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	448	8	1	4	6.0	COc1ccc(F)c(-c2ccc3c(c2)OC[C@@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	164611439	192012	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	313	4	2	1	4.8	Cc1ccc(Cl)cc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4858086	192012	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	313	4	2	1	4.8	Cc1ccc(Cl)cc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	51350272	65615	0	None	107	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1688465	65615	0	None	107	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	66562386	97145	0	None	562	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386363	97145	0	None	562	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	122184685	129230	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	357	7	1	4	4.6	O=C(O)CCc1ccc(OCc2coc(-c3cccc(Cl)c3)n2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600994	129230	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	357	7	1	4	4.6	O=C(O)CCc1ccc(OCc2coc(-c3cccc(Cl)c3)n2)cc1	10.1016/j.bmcl.2015.06.018
	57706778	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL2152070	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acs.jmedchem.1c00031
	57706778	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL2152070	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	57706778	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	CHEMBL2152070	87572	29	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	155533810	178644	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	428	7	1	4	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccccc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4469136	178644	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	428	7	1	4	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccccc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	121294307	187197	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	610	13	1	7	6.6	COc1ccc(C(=O)N(CC(C)(C)C#N)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4752289	187197	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	610	13	1	7	6.6	COc1ccc(C(=O)N(CC(C)(C)C#N)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	24857286	8405	72	None	-3	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	6484	8405	72	None	-3	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	CHEMBL1829174	8405	72	None	-3	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	DB12491	8405	72	None	-3	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
	86803191	129234	3	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	323	7	1	4	3.9	O=C(O)CCc1ccc(OCc2ncc(-c3ccccc3)o2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600998	129234	3	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	323	7	1	4	3.9	O=C(O)CCc1ccc(OCc2ncc(-c3ccccc3)o2)cc1	10.1016/j.bmcl.2015.06.018
	122185434	129443	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	327	7	2	3	3.8	CCOC(CC(=O)O)c1ccc(NC(=O)c2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604032	129443	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	327	7	2	3	3.8	CCOC(CC(=O)O)c1ccc(NC(=O)c2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	818213	162255	9	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	345	5	2	3	3.9	O=C(O)c1ccc(NC(=O)c2ccc(C(=O)c3ccccc3)cc2)cc1	10.1021/jm7012425
	CHEMBL404008	162255	9	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	345	5	2	3	3.9	O=C(O)c1ccc(NC(=O)c2ccc(C(=O)c3ccccc3)cc2)cc1	10.1021/jm7012425
	58319138	93326	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	266	3	2	2	2.8	O=C(O)CCc1ccc(C#Cc2ccccc2O)cc1	10.1021/jm301470a
	CHEMBL2315550	93326	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	266	3	2	2	2.8	O=C(O)CCc1ccc(C#Cc2ccccc2O)cc1	10.1021/jm301470a
	134130696	148915	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	CHEMBL3883449	148915	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	155516498	176901	0	None	-3	2	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4443853	176901	0	None	-3	2	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	137657972	166383	0	None	-40	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	166383	0	None	-40	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	46231654	208463	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3cccc(C(F)(F)F)n3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL606213	208463	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3cccc(C(F)(F)F)n3)cc2)S1	10.1016/j.bmcl.2009.10.052
	127052270	147011	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	343	6	2	6	3.1	O=C(O)CCc1nnc(C(=O)Nc2cccc(-c3ccco3)c2)s1	10.1016/j.bmc.2016.04.065
	CHEMBL3805303	147011	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	343	6	2	6	3.1	O=C(O)CCc1nnc(C(=O)Nc2cccc(-c3ccco3)c2)s1	10.1016/j.bmc.2016.04.065
	118637973	169522	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	3	7.1	CSc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4171391	169522	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	3	7.1	CSc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	54585039	68577	5	None	17	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL1773252	68577	5	None	17	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	24825482	94765	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	7	2	3	5.3	CC(C(=O)O)c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234268	94765	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	7	2	3	5.3	CC(C(=O)O)c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	127027729	144468	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	9	1	5	6.5	O=C1NC(=O)C(Cc2ccc(OCC[C@H](Oc3ccc(Cl)cc3Cl)c3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3758719	144468	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	9	1	5	6.5	O=C1NC(=O)C(Cc2ccc(OCC[C@H](Oc3ccc(Cl)cc3Cl)c3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	127025867	144555	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	395	6	1	6	4.1	CC(C)n1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccccc21	10.1016/j.ejmech.2015.12.049
	CHEMBL3759448	144555	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	395	6	1	6	4.1	CC(C)n1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccccc21	10.1016/j.ejmech.2015.12.049
	797771	101433	14	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	312	6	0	7	3.1	COC(=O)CSc1nnc(SCc2ccccc2)s1	10.1021/jm7012425
	CHEMBL252526	101433	14	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	312	6	0	7	3.1	COC(=O)CSc1nnc(SCc2ccccc2)s1	10.1021/jm7012425
	1201156	161905	17	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	297	5	1	5	2.3	O=C(O)CCCN1C(=O)/C(=C\c2ccco2)SC1=S	10.1021/jm7012425
	CHEMBL402053	161905	17	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	297	5	1	5	2.3	O=C(O)CCCN1C(=O)/C(=C\c2ccco2)SC1=S	10.1021/jm7012425
	46854655	7183	47	None	-8	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
	6485	7183	47	None	-8	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
	CHEMBL1829173	7183	47	None	-8	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
	145965455	170921	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	546	12	1	7	4.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4210139	170921	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	546	12	1	7	4.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	127048843	147034	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	387	6	2	5	4.1	O=C(O)CCc1nnc(C(=O)Nc2cccc(-c3cccc(Cl)c3)c2)s1	10.1016/j.bmc.2016.04.065
	CHEMBL3805558	147034	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	387	6	2	5	4.1	O=C(O)CCc1nnc(C(=O)Nc2cccc(-c3cccc(Cl)c3)c2)s1	10.1016/j.bmc.2016.04.065
	118623088	148905	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883407	148905	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	57414540	82397	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	529	11	1	5	5.9	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047160	82397	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	529	11	1	5	5.9	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	57414676	82399	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	534	9	1	6	6.7	Cc1cc(OCc2cccc3nccn23)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047163	82399	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	534	9	1	6	6.7	Cc1cc(OCc2cccc3nccn23)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	57414677	82400	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	552	13	1	6	5.8	CCc1cc(OCCCS(C)(=O)=O)cc(CC)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047164	82400	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	552	13	1	6	5.8	CCc1cc(OCCCS(C)(=O)=O)cc(CC)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	24857376	82406	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	592	11	1	6	6.6	Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047170	82406	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	592	11	1	6	6.6	Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	121294284	188136	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	613	12	1	6	7.4	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4763105	188136	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	613	12	1	6	7.4	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	121294846	190331	1	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	614	12	1	7	6.8	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cc(C(CC(=O)O)C4CC4)ccn3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4800194	190331	1	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	614	12	1	7	6.8	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cc(C(CC(=O)O)C4CC4)ccn3)CC2)c1	10.1021/acs.jmedchem.0c00843
	162664735	188865	0	None	-7	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4781604	188865	0	None	-7	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
	67087041	189150	0	None	-14	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4785057	189150	0	None	-14	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	68194159	189840	0	None	-4	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4794233	189840	0	None	-4	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
	162674998	190170	0	None	-5	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4798023	190170	0	None	-5	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
	118645756	188241	7	None	-2	3	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764485	188241	7	None	-2	3	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	60195036	88496	0	None	630	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL2163924	88496	0	None	630	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	60195040	88569	0	None	5248	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164241	88569	0	None	5248	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	51350135	65620	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	378	7	1	2	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(F)C(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688470	65620	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	378	7	1	2	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(F)C(=O)O)cc2)c1	10.1021/jm101405t
	51350136	65621	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	7	1	2	5.8	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(C)C(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688471	65621	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	7	1	2	5.8	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(C)C(=O)O)cc2)c1	10.1021/jm101405t
	145974173	171378	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	490	9	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](C)CC(=O)O)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4215771	171378	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	490	9	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](C)CC(=O)O)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	168294830	199012	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	382	8	1	4	4.5	COc1ccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.bmc.2022.116615
	CHEMBL5205109	199012	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	382	8	1	4	4.5	COc1ccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.bmc.2022.116615
	87262743	165560	0	None	4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	449	6	1	4	5.6	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2OC(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4094160	165560	0	None	4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	449	6	1	4	5.6	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2OC(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	145989151	173981	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3c(Cl)cccc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4291567	173981	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3c(Cl)cccc3O2)cc1	10.1016/j.bmc.2018.10.019
	51031010	163410	0	None	-3	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	409	6	1	4	5.0	COc1ccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c(C)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4069191	163410	0	None	-3	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	409	6	1	4	5.0	COc1ccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c(C)c1	10.1021/acs.jmedchem.6b01559
	23082861	65641	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	298	9	1	2	4.1	O=C(O)CCc1ccc(OCCCCc2ccccc2)cc1	10.1021/jm101405t
	CHEMBL1688491	65641	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	298	9	1	2	4.1	O=C(O)CCc1ccc(OCCCCc2ccccc2)cc1	10.1021/jm101405t
	23111708	80824	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	386	6	1	3	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc3c(CC(=O)O)coc3c2)c1	10.1021/ml1000855
	CHEMBL2022246	80824	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	386	6	1	3	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc3c(CC(=O)O)coc3c2)c1	10.1021/ml1000855
	122185431	129440	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	338	8	1	5	3.4	CCOC(Cc1nnn[nH]1)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604029	129440	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	338	8	1	5	3.4	CCOC(Cc1nnn[nH]1)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	58218671	163977	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	341	7	1	4	4.3	CCOc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4075885	163977	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	341	7	1	4	4.3	CCOc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	137661475	166237	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4101348	166237	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	54582629	68930	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777864	68930	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	145950126	169639	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	511	7	1	4	6.1	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4173085	169639	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	511	7	1	4	6.1	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	24825492	156321	0	None	9	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/ml100106c
	CHEMBL394666	156321	0	None	9	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/ml100106c
	44409698	83530	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	374	8	1	3	5.1	CN(C)C(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL206779	83530	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	374	8	1	3	5.1	CN(C)C(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	145967263	171224	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	469	11	1	7	3.6	CO/N=C(\COc1ccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)cc1)c1ccccc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4213829	171224	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	469	11	1	7	3.6	CO/N=C(\COc1ccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)cc1)c1ccccc1	10.1016/j.ejmech.2017.07.001
	54757736	72120	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	283	3	1	2	2.9	Cc1cnc(F)cc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm2005699
	CHEMBL1829164	72120	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	283	3	1	2	2.9	Cc1cnc(F)cc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm2005699
	3367	7939	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/ml100106c
	46216676	7939	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/ml100106c
	CHEMBL604126	7939	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/ml100106c
	127049161	147076	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	397	8	2	6	3.7	Cc1cccc(NC(=O)c2nnc(COc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.bmc.2016.04.065
	CHEMBL3806055	147076	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	397	8	2	6	3.7	Cc1cccc(NC(=O)c2nnc(COc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.bmc.2016.04.065
	145963593	168192	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	463	10	1	6	4.8	COc1ccc(C(OCCOc2ccc(CC3SC(=O)NC3=O)cc2)c2ccccc2)cc1	10.1016/j.bmcl.2018.03.051
	CHEMBL4126802	168192	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	463	10	1	6	4.8	COc1ccc(C(OCCOc2ccc(CC3SC(=O)NC3=O)cc2)c2ccccc2)cc1	10.1016/j.bmcl.2018.03.051
	155517179	176922	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	442	7	1	4	5.4	O=C(O)CCc1ccc(OC[C@@H]2COc3ccc(-c4ccc(Cl)cc4)cc3O2)cc1F	10.1016/j.bmcl.2019.01.014
	CHEMBL4444223	176922	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	442	7	1	4	5.4	O=C(O)CCc1ccc(OC[C@@H]2COc3ccc(-c4ccc(Cl)cc4)cc3O2)cc1F	10.1016/j.bmcl.2019.01.014
	1050	8683	94	None	-1	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	11595431	8683	94	None	-1	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	CHEMBL207881	8683	94	None	-1	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 N244A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	145962072	169147	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	505	7	1	3	6.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4165184	169147	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	505	7	1	3	6.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.ejmech.2018.04.023
	127048844	146976	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	383	8	2	6	3.4	O=C(O)CCc1nnc(C(=O)Nc2ccc(OCc3ccccc3)cc2)s1	10.1016/j.bmc.2016.04.065
	CHEMBL3804883	146976	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	383	8	2	6	3.4	O=C(O)CCc1nnc(C(=O)Nc2ccc(OCc3ccccc3)cc2)s1	10.1016/j.bmc.2016.04.065
	57414402	82389	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047152	82389	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	57414543	82398	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	529	9	1	6	7.2	Cc1nc(C)c(COc2cc(C)c(-c3cccc(COc4ccc5c(c4)OC[C@H]5CC(=O)O)c3)c(C)c2)s1	10.1021/jm300170m
	CHEMBL2047162	82398	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	529	9	1	6	7.2	Cc1nc(C)c(COc2cc(C)c(-c3cccc(COc4ccc5c(c4)OC[C@H]5CC(=O)O)c3)c(C)c2)s1	10.1021/jm300170m
	57414679	82402	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	552	11	1	6	5.9	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OCCCS(C)(=O)=O	10.1021/jm300170m
	CHEMBL2047166	82402	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	552	11	1	6	5.9	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OCCCS(C)(=O)=O	10.1021/jm300170m
	131986115	171494	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	556	11	1	7	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4217348	171494	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	556	11	1	7	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	46231780	207584	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	415	4	1	4	5.4	Cc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	CHEMBL600799	207584	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	415	4	1	4	5.4	Cc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	90644299	118743	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc(C(F)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288357	118743	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc(C(F)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	162667620	189336	0	None	-3	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	CHEMBL4787628	189336	0	None	-3	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	131986075	170688	0	None	2	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	466	7	1	7	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4207273	170688	0	None	2	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	466	7	1	7	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	11674915	65636	1	None	-1	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL1688486	65636	1	None	-1	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2014.04.065
	118645715	188266	0	None	-1	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	6.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764729	188266	0	None	-1	2	Rat	7.8	pEC50	=	7.8	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	6.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	118623088	148905	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883407	148905	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	73345869	97137	0	None	75	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386355	97137	0	None	75	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	66562488	97146	0	None	64	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
	CHEMBL2386364	97146	0	None	64	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
	145970463	171955	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	413	6	1	5	5.1	Cc1noc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1Cl	10.1016/j.bmc.2017.12.030
	CHEMBL4228406	171955	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	413	6	1	5	5.1	Cc1noc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1Cl	10.1016/j.bmc.2017.12.030
	46941175	68586	26	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2005699
	CHEMBL1773261	68586	26	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2005699
	46941175	68586	26	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1773261	68586	26	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	46941175	68586	26	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL1773261	68586	26	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	57402427	76796	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	308	6	1	2	4.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939648	76796	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	308	6	1	2	4.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmcl.2011.10.118
	121294843	189283	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	543	11	1	6	5.6	COc1ccc(C(=O)N(C)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4786992	189283	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	543	11	1	6	5.6	COc1ccc(C(=O)N(C)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	137638341	163548	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	544	7	1	7	5.0	COc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](F)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4070721	163548	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	544	7	1	7	5.0	COc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](F)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	23111671	80832	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4ccc5sccc5c4)c3)ccc21	10.1021/jm2012968
	CHEMBL2022254	80832	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4ccc5sccc5c4)c3)ccc21	10.1021/jm2012968
	58230552	188998	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	CHEMBL4783190	188998	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	853224	101350	11	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	CHEMBL251963	101350	11	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	51350134	65619	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	376	7	1	2	6.3	Cc1cccc(C)c1-c1cccc(CSc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688469	65619	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	376	7	1	2	6.3	Cc1cccc(C)c1-c1cccc(CSc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	168289957	198408	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	398	13	1	4	5.7	COc1ccc(/C=C/c2cc(OC)cc(OCCCCCCCC(=O)O)c2)cc1	10.1016/j.ejmech.2021.114061
	CHEMBL5195742	198408	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	398	13	1	4	5.7	COc1ccc(/C=C/c2cc(OC)cc(OCCCCCCCC(=O)O)c2)cc1	10.1016/j.ejmech.2021.114061
	142738583	169133	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	293	5	2	1	4.4	CCc1ccccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acsmedchemlett.7b00460
	CHEMBL4165039	169133	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	293	5	2	1	4.4	CCc1ccccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acsmedchemlett.7b00460
	142738569	169523	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	343	4	2	1	4.6	O=C(O)CCc1ccc2[nH]c(-c3cccc(Br)c3)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4171403	169523	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	343	4	2	1	4.6	O=C(O)CCc1ccc2[nH]c(-c3cccc(Br)c3)cc2c1	10.1021/acsmedchemlett.7b00460
	1052	9101	85	None	-5	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	3323	9101	85	None	-5	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	5280450	9101	85	None	-5	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	CHEMBL267476	9101	85	None	-5	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	DB14104	9101	85	None	-5	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	145987969	173848	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	346	4	1	2	4.5	O=C(O)C#Cc1ccc(OCc2cccc(-c3cccc(F)c3)c2)cc1	10.1016/j.ejmech.2018.08.075
	CHEMBL4289432	173848	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	346	4	1	2	4.5	O=C(O)C#Cc1ccc(OCc2cccc(-c3cccc(F)c3)c2)cc1	10.1016/j.ejmech.2018.08.075
	137638355	163608	0	None	-97	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	163608	0	None	-97	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	60195125	10660	8	None	-4	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	10660	8	None	-4	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	10660	8	None	-4	3	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at GPR40 in rat INS-1E cells assessed as receptor activation by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	24825509	94721	0	None	29	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/ml100106c
	CHEMBL234057	94721	0	None	29	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/ml100106c
	127033353	145929	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787151	145929	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	134134229	150033	0	None	-61	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 assessed as induction of IP1 accumulationAgonist activity at human GPR40 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	150033	0	None	-61	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 assessed as induction of IP1 accumulationAgonist activity at human GPR40 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	150033	0	None	-61	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	150033	0	None	-61	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	57706097	170521	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4205339	170521	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	58319126	93292	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	292	4	1	2	3.3	CC(=O)c1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315248	93292	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	292	4	1	2	3.3	CC(=O)c1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	54757734	72118	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	327	4	1	2	4.2	O=C(O)CCc1ccc(C#Cc2ccnc(-c3ccccc3)c2)cc1	10.1021/jm2005699
	CHEMBL1829162	72118	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	327	4	1	2	4.2	O=C(O)CCc1ccc(C#Cc2ccnc(-c3ccccc3)c2)cc1	10.1021/jm2005699
	54586984	68581	0	None	34	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/ml100106c
	CHEMBL1773256	68581	0	None	34	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/ml100106c
	23136477	65604	3	None	-15	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL1688455	65604	3	None	-15	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4213909	65604	3	None	-15	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	37289	173301	19	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assay	ChEMBL	216	10	2	2	3.0	CCCCCCC(O)CCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL4279005	173301	19	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assay	ChEMBL	216	10	2	2	3.0	CCCCCCC(O)CCCCC(=O)O	10.1039/C7MD00130D
	127051856	147505	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	630	16	2	10	6.3	Cc1cc(OCCOCCNc2ccc([N+](=O)[O-])c3nonc23)ccc1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/acs.jmedchem.6b00202
	CHEMBL3817889	147505	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at eYFP-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	630	16	2	10	6.3	Cc1cc(OCCOCCNc2ccc([N+](=O)[O-])c3nonc23)ccc1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/acs.jmedchem.6b00202
	145956671	168845	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	533	9	1	7	4.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4cccc([N+](=O)[O-])c4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4160566	168845	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	533	9	1	7	4.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4cccc([N+](=O)[O-])c4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	46231715	207728	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	334	4	1	5	3.4	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL601850	207728	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	334	4	1	5	3.4	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	25766502	129293	3	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	344	6	1	5	3.6	O=C(O)Cc1ccc(OCc2nc(-c3cccc(Cl)c3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601061	129293	3	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	344	6	1	5	3.6	O=C(O)Cc1ccc(OCc2nc(-c3cccc(Cl)c3)no2)cc1	10.1016/j.bmcl.2015.06.018
	127027011	144407	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	409	7	1	6	4.2	CC(C)Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccccc21	10.1016/j.ejmech.2015.12.049
	CHEMBL3758197	144407	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	409	7	1	6	4.2	CC(C)Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccccc21	10.1016/j.ejmech.2015.12.049
	51350406	65637	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c1C	10.1021/jm101405t
	CHEMBL1688487	65637	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c1C	10.1021/jm101405t
	10668	8734	16	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	366	7	1	3	4.8	OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C	10.1016/j.bmcl.2021.127969
	139600331	8734	16	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	366	7	1	3	4.8	OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C	10.1016/j.bmcl.2021.127969
	CHEMBL5169614	8734	16	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	366	7	1	3	4.8	OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C	10.1016/j.bmcl.2021.127969
	44572033	186355	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	548	13	1	5	7.8	O=C(O)CCc1ccc(OCc2ccc(CC(CCc3ccccn3)c3nc(-c4ccccc4)cs3)cc2)cc1	10.1016/j.bmcl.2008.10.085
	CHEMBL474195	186355	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	548	13	1	5	7.8	O=C(O)CCc1ccc(OCc2ccc(CC(CCc3ccccn3)c3nc(-c4ccccc4)cs3)cc2)cc1	10.1016/j.bmcl.2008.10.085
	90655862	118028	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	492	9	1	5	6.7	COc1cc(-c2ccc(COc3cc([C@H](C)CC(=O)O)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265146	118028	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	492	9	1	5	6.7	COc1cc(-c2ccc(COc3cc([C@H](C)CC(=O)O)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	57414680	82403	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	554	8	1	6	5.6	Cc1cc(OC2CCS(=O)(=O)CC2)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047167	82403	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	554	8	1	6	5.6	Cc1cc(OC2CCS(=O)(=O)CC2)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	57414542	83991	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047161	83991	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2079433	83991	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	131986140	170299	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	7	1	5	7.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Br)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4202612	170299	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	7	1	5	7.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Br)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	67058227	125912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	CHEMBL3427713	125912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	122185436	129453	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	334	8	1	3	4.5	CCOC(CC(=O)O)c1ccc(OCc2cccc(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604041	129453	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	334	8	1	3	4.5	CCOC(CC(=O)O)c1ccc(OCc2cccc(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	67087246	189656	5	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4791842	189656	5	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	131986140	170299	0	None	-1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	7	1	5	7.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Br)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4202612	170299	0	None	-1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	7	1	5	7.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Br)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986132	170638	0	None	1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	554	11	3	8	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206640	170638	0	None	1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	554	11	3	8	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986051	170662	0	None	-1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	489	7	1	6	6.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C#N)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206968	170662	0	None	-1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	489	7	1	6	6.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C#N)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	118642372	169243	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	429	7	1	4	5.8	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4166943	169243	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	429	7	1	4	5.8	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	71613314	96772	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	402	4	1	4	5.1	Cc1ccccc1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381308	96772	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	402	4	1	4	5.1	Cc1ccccc1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	149454889	176510	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	385	7	2	3	5.2	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3Cl)c2)cc1F	10.1016/j.ejmech.2019.06.087
	CHEMBL4438440	176510	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	385	7	2	3	5.2	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3Cl)c2)cc1F	10.1016/j.ejmech.2019.06.087
	67072752	93304	0	None	5	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315528	93304	0	None	5	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	67072752	93304	0	None	5	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
	CHEMBL2315528	93304	0	None	5	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
	58172999	129476	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	356	8	1	4	4.3	CCO[C@@H](CC(=O)O)c1ccc(OC2CCc3c(OC)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604064	129476	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	356	8	1	4	4.3	CCO[C@@H](CC(=O)O)c1ccc(OC2CCc3c(OC)cccc32)cc1	10.1016/j.bmc.2015.07.028
	58218571	164259	0	None	17	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	325	6	1	3	4.0	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4079421	164259	0	None	17	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	325	6	1	3	4.0	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	90151435	166497	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	554	8	1	7	5.6	CCOc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4104467	166497	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	554	8	1	7	5.6	CCOc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	162666840	189233	0	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	CHEMBL4786299	189233	0	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	58172989	118746	0	None	-3	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	389	6	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2cc3c(cn2)C(CC(=O)O)OC3)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288360	118746	0	None	-3	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	389	6	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2cc3c(cn2)C(CC(=O)O)OC3)c1	10.1016/j.bmcl.2014.04.065
	71613519	96752	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1ccc(Cl)c(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381288	96752	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1ccc(Cl)c(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	71562770	93305	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	4	1	2	3.2	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315529	93305	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	4	1	2	3.2	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	145965707	170982	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4210871	170982	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	71451164	87438	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	380	8	1	3	5.1	COc1ccc(F)c(-c2ccc(COc3ccc(CCC(=O)O)cc3)cc2)c1	10.1021/ml300133f
	CHEMBL2151291	87438	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	380	8	1	3	5.1	COc1ccc(F)c(-c2ccc(COc3ccc(CCC(=O)O)cc3)cc2)c1	10.1021/ml300133f
	57706588	87445	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	476	9	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151298	87445	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	476	9	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	137638269	163655	0	None	-8	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	7	1	3	5.8	COc1ccc(F)c(-c2ccc(Cc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4071899	163655	0	None	-8	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	7	1	3	5.8	COc1ccc(F)c(-c2ccc(Cc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	58218640	165701	0	None	-15	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2CC[C@H](C)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4095599	165701	0	None	-15	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2CC[C@H](C)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	1202260	101811	9	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	313	5	1	5	2.8	O=C(O)CCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	CHEMBL255071	101811	9	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	313	5	1	5	2.8	O=C(O)CCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	25098573	9523	8	None	-8	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	5587	9523	8	None	-8	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	CHEMBL463785	9523	8	None	-8	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	137633489	163379	0	None	-9	2	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	CHEMBL4068825	163379	0	None	-9	2	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	137647888	164497	0	None	-	1	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4082057	164497	0	None	-	1	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	23136477	65604	3	None	-15	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1688455	65604	3	None	-15	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/ml100106c
	CHEMBL4213909	65604	3	None	-15	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/ml100106c
	127046834	146437	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1ccnc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3797836	146437	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1ccnc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	90151202	164150	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	461	6	1	5	5.0	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccccc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4078050	164150	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	461	6	1	5	5.0	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccccc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	24825509	94721	0	None	29	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234057	94721	0	None	29	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	145976145	170592	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	412	8	1	5	3.8	COc1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4206179	170592	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	412	8	1	5	3.8	COc1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	145971779	171251	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	378	7	1	3	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(SCC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4214140	171251	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	378	7	1	3	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(SCC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	66562388	97149	0	None	33	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386367	97149	0	None	33	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	60195125	10660	8	None	4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	10660	8	None	4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	10660	8	None	4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation in presence of 30 uM FFA1 antagonist TUG-761 by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	127027726	144606	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	463	10	1	6	5.2	COc1cccc(O[C@@H](CCOc2ccc(CC3SC(=O)NC3=O)cc2)c2ccccc2)c1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759866	144606	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	463	10	1	6	5.2	COc1cccc(O[C@@H](CCOc2ccc(CC3SC(=O)NC3=O)cc2)c2ccccc2)c1	10.1016/j.ejmech.2015.12.049
	137641343	163836	0	None	-117	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	163836	0	None	-117	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	153211729	179679	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	405	9	2	4	5.4	CCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4516052	179679	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	405	9	2	4	5.4	CCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	57705575	170931	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	504	10	1	3	8.3	CC[C@@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4210239	170931	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	504	10	1	3	8.3	CC[C@@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	134465785	182890	0	None	-15	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4591657	182890	0	None	-15	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	54586984	68581	0	None	34	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773256	68581	0	None	34	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	71562314	93311	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	3	1	1	3.7	CC(CC(=O)O)c1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	CHEMBL2315535	93311	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	3	1	1	3.7	CC(CC(=O)O)c1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	25149901	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm2005699
	CHEMBL488384	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm2005699
	127030714	145864	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	254	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2=CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786524	145864	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	254	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2=CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	25149901	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL488384	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	25149901	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
	CHEMBL488384	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
	25149901	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL488384	193465	1	None	61	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml100106c
	24825494	94807	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234468	94807	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmcl.2006.12.084
	24825493	156631	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	295	6	2	3	4.0	O=C(O)CCc1ccc(NCc2ccc(Cl)s2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL394900	156631	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	295	6	2	3	4.0	O=C(O)CCc1ccc(NCc2ccc(Cl)s2)cc1	10.1016/j.bmcl.2006.12.084
	137638911	163508	0	None	-32	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	163508	0	None	-32	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137638355	163608	0	None	-97	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	163608	0	None	-97	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137641343	163836	0	None	-117	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	163836	0	None	-117	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	164626510	193116	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	549	8	1	4	7.1	C[C@H](C(=O)O)[C@@H](c1ccc2c(c1)O[C@@H](C1CCN([C@@H](C)c3cc(F)ccc3OC(F)(F)F)CC1)CC2)C1CC1	10.1021/acs.jmedchem.1c00031
	CHEMBL4874972	193116	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	549	8	1	4	7.1	C[C@H](C(=O)O)[C@@H](c1ccc2c(c1)O[C@@H](C1CCN([C@@H](C)c3cc(F)ccc3OC(F)(F)F)CC1)CC2)C1CC1	10.1021/acs.jmedchem.1c00031
	134465732	178254	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4463571	178254	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	137529972	171542	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	556	8	3	8	5.2	Cc1cc(-c2nnn(CC(C)(C)O)n2)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	CHEMBL4217914	171542	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	556	8	3	8	5.2	Cc1cc(-c2nnn(CC(C)(C)O)n2)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	118129999	164546	0	None	2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4082711	164546	0	None	2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	118645685	186647	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	492	10	1	5	6.4	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4745513	186647	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	492	10	1	5	6.4	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1	10.1016/j.bmcl.2018.01.013
	118645756	188241	7	None	-1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764485	188241	7	None	-1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	131986061	170895	0	None	6	2	Rat	8.7	pEC50	=	8.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	518	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4209834	170895	0	None	6	2	Rat	8.7	pEC50	=	8.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	518	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	155528372	178096	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	479	8	1	4	6.3	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c(F)cn1	10.1016/j.bmcl.2019.04.050
	CHEMBL4461095	178096	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	479	8	1	4	6.3	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c(F)cn1	10.1016/j.bmcl.2019.04.050
	67087095	190154	0	None	-6	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4797858	190154	0	None	-6	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	134465730	179582	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4513748	179582	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	162674998	190170	0	None	-5	3	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4798023	190170	0	None	-5	3	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
	118637996	148948	0	None	15	2	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883819	148948	0	None	15	2	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4162778	148948	0	None	15	2	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	164625212	192762	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	333	4	2	1	5.2	O=C(O)CCc1ccc2[nH]c(-c3c(Cl)cccc3Cl)cc2c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4869870	192762	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	333	4	2	1	5.2	O=C(O)CCc1ccc2[nH]c(-c3c(Cl)cccc3Cl)cc2c1	10.1021/acs.jmedchem.1c00031
	44409722	147794	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL382381	147794	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	118645789	186836	0	None	11	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	478	12	1	5	6.2	CCCCc1nc(COc2cccc([C@@H](CC(=O)O)C3CC3)c2)cnc1-c1cc(OC)ccc1F	10.1016/j.bmcl.2018.01.013
	CHEMBL4747793	186836	0	None	11	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	478	12	1	5	6.2	CCCCc1nc(COc2cccc([C@@H](CC(=O)O)C3CC3)c2)cnc1-c1cc(OC)ccc1F	10.1016/j.bmcl.2018.01.013
	118623101	174368	0	None	-12	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159416	174368	0	None	-12	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300796	174368	0	None	-12	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	118642344	148900	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883380	148900	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc([C@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	90356885	174314	0	None	-16	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4168422	174314	0	None	-16	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300181	174314	0	None	-16	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	68194127	189974	0	None	-1	3	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4795763	189974	0	None	-1	3	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	68194465	190085	0	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4797124	190085	0	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	51350404	65634	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1021/jm101405t
	CHEMBL1688484	65634	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1021/jm101405t
	67072752	93304	0	None	5	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315528	93304	0	None	5	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	66562288	145787	0	None	1000	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785637	145787	0	None	1000	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	131986401	170763	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4208095	170763	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986050	171265	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4214289	171265	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	45107307	118748	4	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1021/ml500391n
	CHEMBL3288362	118748	4	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1021/ml500391n
	45107307	118748	4	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3288362	118748	4	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	122185452	129479	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	395	7	1	4	4.7	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)nc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604067	129479	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	395	7	1	4	4.7	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)nc1	10.1016/j.bmc.2015.07.028
	45107307	118748	4	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288362	118748	4	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmcl.2014.04.065
	155549083	180447	0	None	6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4534836	180447	0	None	6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	145952952	169270	0	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4167323	169270	0	None	-1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	23082877	82597	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1-c1c(C)cccc1C	10.1021/jm2016123
	CHEMBL2048613	82597	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1-c1c(C)cccc1C	10.1021/jm2016123
	162668378	189286	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4787010	189286	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
	131986065	170632	0	None	4	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	465	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206579	170632	0	None	4	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	465	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986050	171265	0	None	-1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4214289	171265	0	None	-1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	66562288	145787	0	None	1000	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785637	145787	0	None	1000	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	164618830	192540	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	333	4	2	1	5.2	O=C(O)CCc1ccc2[nH]c(-c3ccc(Cl)cc3Cl)cc2c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4866406	192540	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	333	4	2	1	5.2	O=C(O)CCc1ccc2[nH]c(-c3ccc(Cl)cc3Cl)cc2c1	10.1021/acs.jmedchem.1c00031
	155519364	177156	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	476	8	1	5	5.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(OC)cc4F)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4447826	177156	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	476	8	1	5	5.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(OC)cc4F)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	145987796	173905	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	464	6	1	4	4.9	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(Br)c(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4290397	173905	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	464	6	1	4	4.9	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(Br)c(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	118645367	188441	0	None	-5	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4776217	188441	0	None	-5	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	134153546	159360	0	None	-8	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971857	159360	0	None	-8	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137632610	163125	0	None	2	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4065890	163125	0	None	2	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	134139528	161317	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	547	11	1	5	6.2	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3921121	161317	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	547	11	1	5	6.2	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990894	161317	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	547	11	1	5	6.2	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(OCc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	137657027	166359	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	373	7	1	4	5.1	O=C(O)CCc1ccc(OCc2cccc(-c3ccncc3Cl)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4102878	166359	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	373	7	1	4	5.1	O=C(O)CCc1ccc(OCc2cccc(-c3ccncc3Cl)c2)s1	10.1021/acs.jmedchem.6b01357
	46231486	207123	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	4	1	4	3.7	Cc1cccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	CHEMBL597638	207123	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	4	1	4	3.7	Cc1cccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	145949924	169647	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	507	8	1	6	4.4	CC#CC(CC(=O)O)c1ccc(OCc2cnc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4173246	169647	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	507	8	1	6	4.4	CC#CC(CC(=O)O)c1ccc(OCc2cnc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	51349861	65603	0	None	77	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/ml100106c
	CHEMBL1688454	65603	0	None	77	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/ml100106c
	44409883	148007	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	500	7	3	5	5.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC2CCNC2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL382884	148007	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	500	7	3	5	5.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC2CCNC2)cc1	10.1016/j.bmcl.2006.01.007
	44409906	83561	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	349	8	2	4	4.6	O=C(O)COc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.ejmech.2019.06.087
	CHEMBL206880	83561	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	349	8	2	4	4.6	O=C(O)COc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.ejmech.2019.06.087
	57521814	83044	0	None	-10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058525	83044	0	None	-10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	58319089	93294	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	294	5	2	2	2.6	O=C(O)CCc1ccc(C#Cc2ccccc2CCO)cc1	10.1021/jm301470a
	CHEMBL2315250	93294	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	294	5	2	2	2.6	O=C(O)CCc1ccc(C#Cc2ccccc2CCO)cc1	10.1021/jm301470a
	44409906	83561	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	349	8	2	4	4.6	O=C(O)COc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL206880	83561	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	349	8	2	4	4.6	O=C(O)COc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	71615469	96767	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	576	9	1	7	5.4	CS(=O)(=O)CCCOc1ccc(-c2cc(F)cc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381303	96767	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	576	9	1	7	5.4	CS(=O)(=O)CCCOc1ccc(-c2cc(F)cc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	137630008	167810	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	561	12	1	5	6.7	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4077784	167810	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	561	12	1	5	6.7	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116425	167810	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	561	12	1	5	6.7	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	46231595	206973	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	367	4	1	4	4.7	O=C1NC(=O)C(Cc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL596666	206973	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	367	4	1	4	4.7	O=C1NC(=O)C(Cc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)S1	10.1016/j.bmcl.2009.10.052
	127031002	145865	0	None	165	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786526	145865	0	None	165	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	10466	173449	80	None	-12	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	CHEMBL4281719	173449	80	None	-12	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in Flp-In T-Rex 293 cells assessed as induction of Ca2+ mobilization after 45 mins by Fura2-AM dye-based fluorescence assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	46231435	207385	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	309	4	1	3	3.8	O=C1NC(=O)C(Cc2ccc(/C=C/c3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL599271	207385	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	309	4	1	3	3.8	O=C1NC(=O)C(Cc2ccc(/C=C/c3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	45107320	129478	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	396	7	1	4	4.8	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2COc3c2cccc3C(F)(F)F)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604066	129478	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	396	7	1	4	4.8	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2COc3c2cccc3C(F)(F)F)cc1	10.1016/j.bmc.2015.07.028
	23111791	80830	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	424	6	1	3	6.3	Cc1ccc2ccccc2c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022252	80830	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	424	6	1	3	6.3	Cc1ccc2ccccc2c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
	67087095	190154	0	None	-6	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4797858	190154	0	None	-6	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	131986250	170464	0	None	3	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	471	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4204776	170464	0	None	3	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	471	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986130	171204	0	None	1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	572	11	1	7	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4213597	171204	0	None	1	2	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	572	11	1	7	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	162652399	187007	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4749949	187007	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	71460547	88495	27	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm3002026
	CHEMBL2163923	88495	27	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm3002026
	75511310	129236	1	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	352	8	1	5	3.9	CCc1ccc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601000	129236	1	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	352	8	1	5	3.9	CCc1ccc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	145973329	171514	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	522	10	1	3	8.5	CC[C@H](CC(=O)O)c1cc(OCc2ccc(-c3cc(OC)ccc3F)c(C3CCCC3(C)C)c2)ccc1F	10.1021/acsmedchemlett.8b00213
	CHEMBL4217580	171514	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	522	10	1	3	8.5	CC[C@H](CC(=O)O)c1cc(OCc2ccc(-c3cc(OC)ccc3F)c(C3CCCC3(C)C)c2)ccc1F	10.1021/acsmedchemlett.8b00213
	137648439	164659	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	396	8	1	4	5.8	COC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4083960	164659	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	396	8	1	4	5.8	COC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	137654021	165571	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	404	7	1	3	6.2	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4094216	165571	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	404	7	1	3	6.2	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	58172998	129445	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.3	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(F)c1	10.1016/j.bmc.2015.07.028
	CHEMBL3604034	129445	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.3	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(F)c1	10.1016/j.bmc.2015.07.028
	75204360	164396	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	496	7	1	5	5.1	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4081072	164396	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	496	7	1	5	5.1	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	145982132	173348	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	370	6	1	4	3.6	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(F)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4279826	173348	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	370	6	1	4	3.6	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(F)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	145993162	173760	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	430	6	1	4	4.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Br)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4287731	173760	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	430	6	1	4	4.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Br)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	145988796	174078	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	404	6	1	4	4.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(F)c(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4293798	174078	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	404	6	1	4	4.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cc(F)c(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	132606863	164602	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assayAgonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4083365	164602	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assayAgonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	90644287	118731	0	None	-2	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nc2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288345	118731	0	None	-2	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nc2)c1	10.1016/j.bmcl.2014.04.065
	71449363	87449	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	518	9	1	3	8.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCCCC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151301	87449	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	518	9	1	3	8.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCCCC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	25261467	87570	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	504	8	1	3	7.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C(F)(F)F)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2152068	87570	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	504	8	1	3	7.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C(F)(F)F)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	168273292	197312	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	409	7	1	5	5.1	O=C(O)COc1ccc(COc2cccc(-c3nc4ccccc4s3)c2)cc1F	10.1016/j.ejmech.2021.114061
	CHEMBL5179638	197312	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	409	7	1	5	5.1	O=C(O)COc1ccc(COc2cccc(-c3nc4ccccc4s3)c2)cc1F	10.1016/j.ejmech.2021.114061
	122185441	129462	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	315	8	1	4	3.5	CCOC(CC(=O)O)c1ccc(OCc2cccnc2C)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604050	129462	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	315	8	1	4	3.5	CCOC(CC(=O)O)c1ccc(OCc2cccnc2C)cc1	10.1016/j.bmc.2015.07.028
	137637488	162696	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	5	1	3	4.5	O=C(O)C1CCN(c2ccc(OCc3ccc(Cl)cc3Cl)cc2)C1	10.1021/acs.jmedchem.6b01559
	CHEMBL4060859	162696	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	5	1	3	4.5	O=C(O)C1CCN(c2ccc(OCc3ccc(Cl)cc3Cl)cc2)C1	10.1021/acs.jmedchem.6b01559
	134155480	158030	0	None	-38	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3960231	158030	0	None	-38	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	145989566	173935	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	377	6	1	5	3.4	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(C#N)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4290886	173935	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	377	6	1	5	3.4	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(C#N)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	137651638	164000	0	None	-7	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4076190	164000	0	None	-7	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	90644297	118741	0	None	-32	2	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.2	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(C)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288355	118741	0	None	-32	2	Rat	5.7	pEC50	=	5.7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.2	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(C)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	25109512	196543	0	None	-12	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	CHEMBL515995	196543	0	None	-12	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	127025866	144491	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	7	1	6	3.7	C=CCn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccccc21	10.1016/j.ejmech.2015.12.049
	CHEMBL3758885	144491	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	7	1	6	3.7	C=CCn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccccc21	10.1016/j.ejmech.2015.12.049
	145956069	169476	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	502	8	1	5	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(C)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4170517	169476	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	502	8	1	5	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(C)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	145989900	173802	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	360	7	1	4	3.6	COc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CC2	10.1016/j.bmc.2018.10.019
	CHEMBL4288499	173802	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	360	7	1	4	3.6	COc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CC2	10.1016/j.bmc.2018.10.019
	86803188	129282	1	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	356	7	1	5	3.8	Cc1cc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)ccc1F	10.1016/j.bmcl.2015.06.018
	CHEMBL3601050	129282	1	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	356	7	1	5	3.8	Cc1cc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)ccc1F	10.1016/j.bmcl.2015.06.018
	131986164	171398	0	None	-1	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4216016	171398	0	None	-1	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	478	7	1	5	6.6	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	145966699	171053	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	435	7	1	6	4.0	Cc1noc(C)c1-c1cc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)ccc1Cl	10.1016/j.ejmech.2017.07.001
	CHEMBL4211760	171053	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	435	7	1	6	4.0	Cc1noc(C)c1-c1cc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)ccc1Cl	10.1016/j.ejmech.2017.07.001
	145972079	171345	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	417	7	1	6	3.9	Cc1cccc(-c2nc(C)c(COc3ccc(S(=O)(=O)CC(=O)O)cc3)s2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4215289	171345	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	417	7	1	6	3.9	Cc1cccc(-c2nc(C)c(COc3ccc(S(=O)(=O)CC(=O)O)cc3)s2)c1	10.1016/j.ejmech.2017.07.001
	145960453	168271	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	433	9	1	5	4.8	O=C1NC(=O)C(Cc2ccc(OCCOC(c3ccccc3)c3ccccc3)cc2)S1	10.1016/j.bmcl.2018.03.051
	CHEMBL4127972	168271	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	433	9	1	5	4.8	O=C1NC(=O)C(Cc2ccc(OCCOC(c3ccccc3)c3ccccc3)cc2)S1	10.1016/j.bmcl.2018.03.051
	71655225	97138	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)cn1	10.1021/ml4000673
	CHEMBL2386356	97138	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)cn1	10.1021/ml4000673
	54586010	68572	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(CNc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1773247	68572	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(CNc2ccccc2)cc1	10.1021/ml100106c
	127045888	146446	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	393	6	1	4	4.4	Cc1noc(C)c1C#Cc1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3797889	146446	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	393	6	1	4	4.4	Cc1noc(C)c1C#Cc1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	118145019	180435	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	464	8	1	3	6.7	COc1ccc(F)c(-c2cc(F)c3c(c2)CC[C@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4534543	180435	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	464	8	1	3	6.7	COc1ccc(F)c(-c2cc(F)c3c(c2)CC[C@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	145976702	170733	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	397	8	2	6	3.7	Cc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4207755	170733	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	397	8	2	6	3.7	Cc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	137638911	163508	0	None	-32	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	163508	0	None	-32	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	46231716	208459	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	382	4	1	5	4.1	Cc1cc(C(F)(F)F)cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)n1	10.1016/j.bmcl.2009.10.052
	CHEMBL606207	208459	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	382	4	1	5	4.1	Cc1cc(C(F)(F)F)cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)n1	10.1016/j.bmcl.2009.10.052
	24825484	94766	0	None	208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234269	94766	0	None	208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	58319118	93328	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	280	4	1	2	3.1	COc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315552	93328	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	280	4	1	2	3.1	COc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	71613517	96750	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	346	3	1	4	3.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381286	96750	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	346	3	1	4	3.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	154005	170060	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	366	6	1	5	3.6	O=C1NC(=O)C(Cc2ccc(OCCn3ccc4ccccc43)cc2)S1	10.1016/j.bmcl.2018.03.051
	CHEMBL418695	170060	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	366	6	1	5	3.6	O=C1NC(=O)C(Cc2ccc(OCCn3ccc4ccccc43)cc2)S1	10.1016/j.bmcl.2018.03.051
	90655863	118030	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	516	7	1	5	6.5	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265148	118030	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	516	7	1	5	6.5	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	57414405	82392	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047155	82392	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
	23111781	80825	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/ml1000855
	CHEMBL2022247	80825	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/ml1000855
	134465730	179582	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4513748	179582	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	11674915	65636	1	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
	CHEMBL1688486	65636	1	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
	68194476	189666	0	None	-6	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4792075	189666	0	None	-6	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
	134131511	148936	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883627	148936	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	71655227	97144	0	None	173	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386362	97144	0	None	173	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	155548258	180545	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	399	7	2	3	5.5	Cc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(Cl)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4537190	180545	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	399	7	2	3	5.5	Cc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(Cl)c1	10.1016/j.ejmech.2019.06.087
	127047528	146547	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	399	8	1	5	4.7	COc1ccc(COc2ccc(CCC(=O)O)c(F)c2)cc1-c1c(C)noc1C	10.1016/j.ejmech.2016.03.054
	CHEMBL3798575	146547	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	399	8	1	5	4.7	COc1ccc(COc2ccc(CCC(=O)O)c(F)c2)cc1-c1c(C)noc1C	10.1016/j.ejmech.2016.03.054
	168269875	196797	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	410	9	1	4	5.2	CCOc1ccc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5171641	196797	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	410	9	1	4	5.2	CCOc1ccc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	155511380	176335	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	496	7	1	4	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(C(F)(F)F)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4435633	176335	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	496	7	1	4	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(C(F)(F)F)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	155526126	177828	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	429	7	1	5	4.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4cccnc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4456918	177828	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	429	7	1	5	4.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4cccnc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	137633101	163357	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	380	6	1	4	4.4	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cn1	10.1021/acs.jmedchem.6b01559
	CHEMBL4068606	163357	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	380	6	1	4	4.4	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cn1	10.1021/acs.jmedchem.6b01559
	137638269	163655	0	None	8	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	7	1	3	5.8	COc1ccc(F)c(-c2ccc(Cc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4071899	163655	0	None	8	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	7	1	3	5.8	COc1ccc(F)c(-c2ccc(Cc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	90151625	164506	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	523	8	1	6	5.5	CCOc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4082133	164506	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	523	8	1	6	5.5	CCOc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	155551422	180746	0	None	-15	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	454	9	1	3	6.8	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(C)(C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4541658	180746	0	None	-15	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	454	9	1	3	6.8	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(C)(C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	57706720	87444	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	478	9	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C(C)C)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151297	87444	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	478	9	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C(C)C)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	16738034	92541	0	None	-	1	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretionAgonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretion	ChEMBL	326	9	1	2	5.1	CCC(CC)COc1ccc(C(CC(=O)O)c2ccccc2)cc1	10.1021/jm070130j
	CHEMBL229225	92541	0	None	-	1	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretionAgonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretion	ChEMBL	326	9	1	2	5.1	CCC(CC)COc1ccc(C(CC(=O)O)c2ccccc2)cc1	10.1021/jm070130j
	1050	8683	94	None	-1	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	11595431	8683	94	None	-1	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	CHEMBL207881	8683	94	None	-1	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H86A mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	134155847	157881	0	None	-63	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959144	157881	0	None	-63	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	145985116	172675	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	519	7	1	4	6.1	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4cccc5c4CCN(C(=O)c4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4249862	172675	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	519	7	1	4	6.1	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4cccc5c4CCN(C(=O)c4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	46231484	207094	3	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	283	3	1	3	3.2	O=C1NC(=O)C(Cc2ccc(-c3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL597435	207094	3	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	283	3	1	3	3.2	O=C1NC(=O)C(Cc2ccc(-c3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	71562527	93330	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	334	4	1	2	4.0	O=C(O)CCc1ccc(C#Cc2ccccc2OC(F)(F)F)cc1	10.1021/jm301470a
	CHEMBL2315554	93330	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	334	4	1	2	4.0	O=C(O)CCc1ccc(C#Cc2ccccc2OC(F)(F)F)cc1	10.1021/jm301470a
	1050	8683	94	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	11595431	8683	94	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	CHEMBL207881	8683	94	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	53248848	68942	0	None	2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777876	68942	0	None	2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	145992642	173674	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	410	6	1	4	3.8	O=C(O)CCc1ccc(OCC2COc3ccc(Br)cc3O2)cc1F	10.1016/j.bmc.2018.10.019
	CHEMBL4286165	173674	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	410	6	1	4	3.8	O=C(O)CCc1ccc(OCC2COc3ccc(Br)cc3O2)cc1F	10.1016/j.bmc.2018.10.019
	149378333	178662	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	370	7	2	5	4.2	Cc1noc(C)c1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4469534	178662	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	370	7	2	5	4.2	Cc1noc(C)c1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	1201222	161906	9	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	325	5	1	4	2.9	O=C(O)CCCN1C(=O)/C(=C\c2ccc(F)cc2)SC1=S	10.1021/jm7012425
	CHEMBL402054	161906	9	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	325	5	1	4	2.9	O=C(O)CCCN1C(=O)/C(=C\c2ccc(F)cc2)SC1=S	10.1021/jm7012425
	46231651	206198	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3ncccc3C(F)(F)F)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL591214	206198	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3ncccc3C(F)(F)F)cc2)S1	10.1016/j.bmcl.2009.10.052
	71562313	93310	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	262	2	1	1	3.5	Cc1ccccc1C#Cc1ccc(/C=C/C(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315534	93310	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	262	2	1	1	3.5	Cc1ccccc1C#Cc1ccc(/C=C/C(=O)O)cc1	10.1021/jm301470a
	131986057	170434	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4204345	170434	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	23111704	80822	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/ml1000855
	CHEMBL2022244	80822	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/ml1000855
	58172961	129456	2	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	392	10	1	4	5.6	CCOC(CC(=O)O)c1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604044	129456	2	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	392	10	1	4	5.6	CCOC(CC(=O)O)c1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmc.2015.07.028
	11236925	82603	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	478	9	1	4	6.3	Cc1cc(OC2CCOCC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL2048619	82603	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	478	9	1	4	6.3	Cc1cc(OC2CCOCC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	12002202	82609	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	525	9	2	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL2048626	82609	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	525	9	2	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	67087160	189123	0	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4784555	189123	0	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	162673875	189765	0	None	-13	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4793371	189765	0	None	-13	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
	145952952	169270	0	None	-1	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4167323	169270	0	None	-1	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	46854655	7183	47	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2011.10.118
	6485	7183	47	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2011.10.118
	CHEMBL1829173	7183	47	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2011.10.118
	118637972	169096	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	428	7	1	3	6.4	COc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4164618	169096	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	428	7	1	3	6.4	COc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	90372616	149011	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	60195039	88568	0	None	181	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164240	88568	0	None	181	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	118645392	186888	0	None	-2	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	494	12	1	6	5.9	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2OCC(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4748392	186888	0	None	-2	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	494	12	1	6	5.9	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2OCC(C)C)c1	10.1016/j.bmcl.2018.01.013
	90644302	118747	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	301	8	1	4	3.2	CCOC(CC(=O)O)c1ccc(OCc2ccccc2)nc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288361	118747	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	301	8	1	4	3.2	CCOC(CC(=O)O)c1ccc(OCc2ccccc2)nc1	10.1016/j.bmcl.2014.04.065
	71456495	87434	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	400	8	1	3	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(-c3cccc(OC)c3)cc2)cc1	10.1021/ml300133f
	CHEMBL2151287	87434	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	400	8	1	3	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(-c3cccc(OC)c3)cc2)cc1	10.1021/ml300133f
	71449362	87437	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	418	8	1	3	5.7	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(-c3cc(OC)ccc3F)cc2)cc1	10.1021/ml300133f
	CHEMBL2151290	87437	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	418	8	1	3	5.7	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(-c3cc(OC)ccc3F)cc2)cc1	10.1021/ml300133f
	58218655	162944	0	None	-2	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	341	6	1	4	3.9	CO[C@H]1C[C@@H](CC(=O)O)N(c2ccc(Oc3ccccc3C)cc2)C1	10.1021/acs.jmedchem.6b01559
	CHEMBL4063889	162944	0	None	-2	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	341	6	1	4	3.9	CO[C@H]1C[C@@H](CC(=O)O)N(c2ccc(Oc3ccccc3C)cc2)C1	10.1021/acs.jmedchem.6b01559
	145955723	169315	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	533	9	1	7	4.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4167970	169315	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	533	9	1	7	4.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	127025858	144514	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	391	5	1	4	3.9	O=C1NC(=O)C(Cc2ccc(OCc3ccc(Br)cc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759133	144514	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	391	5	1	4	3.9	O=C1NC(=O)C(Cc2ccc(OCc3ccc(Br)cc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	137635513	162889	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2csc(CCC(=O)O)c2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4063167	162889	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2csc(CCC(=O)O)c2)c1	10.1021/acs.jmedchem.6b01357
	164609159	191252	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN3CCC4(CCc5ccccc54)CC3)c2)cc1	10.1021/acs.jmedchem.1c00031
	CHEMBL4846948	191252	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN3CCC4(CCc5ccccc54)CC3)c2)cc1	10.1021/acs.jmedchem.1c00031
	51049992	152397	5	None	-23	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.bmcl.2016.10.074
	CHEMBL3915620	152397	5	None	-23	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.bmcl.2016.10.074
	145976748	170327	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	430	7	1	4	5.7	COc1cc(C)c(-c2cccc(COc3ccc4c(c3)C(=O)CC4CC(=O)O)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4202936	170327	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	430	7	1	4	5.7	COc1cc(C)c(-c2cccc(COc3ccc4c(c3)C(=O)CC4CC(=O)O)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	145976172	170655	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	435	7	1	6	4.0	Cc1noc(C)c1-c1ccc(Cl)c(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4206875	170655	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	435	7	1	6	4.0	Cc1noc(C)c1-c1ccc(Cl)c(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	46231922	208119	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	452	4	1	5	5.6	O=C1NC(=O)C(Cc2ccc(Oc3ncc(C(F)(F)F)cc3Cl)c3ccccc23)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL604317	208119	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	452	4	1	5	5.6	O=C1NC(=O)C(Cc2ccc(Oc3ncc(C(F)(F)F)cc3Cl)c3ccccc23)S1	10.1016/j.bmcl.2009.10.052
	137628912	167759	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	594	12	1	6	7.1	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc5ccccc5n3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4101806	167759	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	594	12	1	6	7.1	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc5ccccc5n3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116012	167759	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	594	12	1	6	7.1	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc5ccccc5n3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	46231652	207891	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3cc(C(F)(F)F)ccn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL603063	207891	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3cc(C(F)(F)F)ccn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	145991968	173616	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	404	10	1	5	3.6	COCCOc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CC2	10.1016/j.bmc.2018.10.019
	CHEMBL4285148	173616	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	404	10	1	5	3.6	COCCOc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CC2	10.1016/j.bmc.2018.10.019
	46231547	208906	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1ccc(C)c(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	CHEMBL609034	208906	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1ccc(C)c(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	145986696	173993	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	362	8	1	4	4.1	O=C(O)C[C@@H]1COc2cc(OCCCOc3cccc(Cl)c3)ccc21	10.1016/j.ejmech.2018.09.071
	CHEMBL4291932	173993	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	362	8	1	4	4.1	O=C(O)C[C@@H]1COc2cc(OCCCOc3cccc(Cl)c3)ccc21	10.1016/j.ejmech.2018.09.071
	131986162	171615	0	None	3	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	414	7	1	5	5.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218822	171615	0	None	3	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	414	7	1	5	5.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	24825492	156321	0	None	9	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL394666	156321	0	None	9	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	75511298	129283	2	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	338	7	1	5	3.9	CC(Oc1ccc(CCC(=O)O)cc1)c1nc(-c2ccccc2)no1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601051	129283	2	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	338	7	1	5	3.9	CC(Oc1ccc(CCC(=O)O)cc1)c1nc(-c2ccccc2)no1	10.1016/j.bmcl.2015.06.018
	145975621	170533	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	401	7	2	5	4.1	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3ccc(Cl)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4205508	170533	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	401	7	2	5	4.1	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3ccc(Cl)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	145974509	171528	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	401	7	2	5	4.1	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3cccc(Cl)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4217742	171528	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	401	7	2	5	4.1	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3cccc(Cl)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	57414401	82388	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047151	82388	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
	23111693	80833	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	418	7	1	4	5.5	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-c1c(C)cccc1C	10.1021/jm2012968
	CHEMBL2022255	80833	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	418	7	1	4	5.5	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-c1c(C)cccc1C	10.1021/jm2012968
	162676881	190364	0	None	-10	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4800563	190364	0	None	-10	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	131986115	171494	0	None	-1	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	556	11	1	7	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4217348	171494	0	None	-1	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	556	11	1	7	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	145947998	174495	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4171104	174495	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302546	174495	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	149144496	181970	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	423	9	2	4	5.6	CCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4570807	181970	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	423	9	2	4	5.6	CCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	127045864	146516	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	399	8	1	5	4.7	COc1ccc(-c2c(C)noc2C)cc1COc1ccc(CCC(=O)O)c(F)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798341	146516	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	399	8	1	5	4.7	COc1ccc(-c2c(C)noc2C)cc1COc1ccc(CCC(=O)O)c(F)c1	10.1016/j.ejmech.2016.03.054
	127046960	146769	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3799946	146769	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL4227915	146769	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	51350271	65614	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c1	10.1021/jm101405t
	CHEMBL1688464	65614	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c1	10.1021/jm101405t
	149231065	182214	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	442	7	1	4	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(C)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4576378	182214	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	442	7	1	4	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(C)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	46231594	207682	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	333	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL601504	207682	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	333	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	57390188	76800	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939652	76800	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmcl.2011.10.118
	137648780	164379	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	540	12	1	6	6.0	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4080911	164379	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	540	12	1	6	6.0	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	5353640	168270	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	278	13	1	1	5.7	CCCCC/C=C/C/C=C/C/C=C/CCCCC(=O)O	10.1016/j.bmcl.2018.03.051
	CHEMBL4127920	168270	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	278	13	1	1	5.7	CCCCC/C=C/C/C=C/C/C=C/CCCCC(=O)O	10.1016/j.bmcl.2018.03.051
	132606864	164525	0	None	2	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assayAgonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4082395	164525	0	None	2	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assayAgonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	137635715	162855	0	None	-9	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1cccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4062765	162855	0	None	-9	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1cccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01559
	132606864	164525	0	None	-2	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4082395	164525	0	None	-2	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	137652992	165428	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(OCc2ccc(CCC(=O)O)s2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4092577	165428	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(OCc2ccc(CCC(=O)O)s2)c1	10.1021/acs.jmedchem.6b01357
	90356885	174314	0	None	-16	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4168422	174314	0	None	-16	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300181	174314	0	None	-16	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	145976979	170777	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	413	9	2	7	3.4	COc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4208272	170777	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	413	9	2	7	3.4	COc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	145985686	172209	0	None	-354	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4238809	172209	0	None	-354	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	54580627	68941	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777875	68941	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
	155528372	178096	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	479	8	1	4	6.3	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c(F)cn1	10.1016/j.bmcl.2019.04.050
	CHEMBL4461095	178096	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	479	8	1	4	6.3	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c(F)cn1	10.1016/j.bmcl.2019.04.050
	54586983	68576	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	266	4	1	2	4.1	O=C(O)CCc1ccc2oc(-c3ccccc3)cc2c1	10.1021/ml100106c
	CHEMBL1773251	68576	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	266	4	1	2	4.1	O=C(O)CCc1ccc2oc(-c3ccccc3)cc2c1	10.1021/ml100106c
	763016	101812	26	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	271	4	2	4	2.7	O=C(O)c1ccc(NCc2ccc3c(c2)OCO3)cc1	10.1021/jm7012425
	CHEMBL255073	101812	26	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	271	4	2	4	2.7	O=C(O)c1ccc(NCc2ccc3c(c2)OCO3)cc1	10.1021/jm7012425
	145947998	174495	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4171104	174495	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302546	174495	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	54582629	68930	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777864	68930	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	118637996	148948	0	None	-15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883819	148948	0	None	-15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4162778	148948	0	None	-15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	118637996	148948	0	None	-15	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883819	148948	0	None	-15	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL4162778	148948	0	None	-15	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	21322577	68925	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	324	5	1	2	5.4	CC(CC(=O)O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777859	68925	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	324	5	1	2	5.4	CC(CC(=O)O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	53248848	68942	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777876	68942	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	131986300	170406	0	None	2	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	528	8	1	6	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4203837	170406	0	None	2	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	528	8	1	6	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	57393692	76802	11	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	438	7	1	2	6.5	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939654	76802	11	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	438	7	1	2	6.5	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2011.10.118
	11226058	82605	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	514	12	1	5	5.5	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2048622	82605	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	514	12	1	5	5.5	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	11203294	82606	3	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL2048623	82606	3	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	145950347	169617	0	None	1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	506	8	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4172828	169617	0	None	1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	506	8	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	11203294	82606	3	None	-	1	Human	7.6	pEC50	=	7.6	Functional	FLIPR functional assay (Ca influx activity of CHO cells)FLIPR functional assay (Ca influx activity of CHO cells)	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.6019/CHEMBL5058642
	CHEMBL2048623	82606	3	None	-	1	Human	7.6	pEC50	=	7.6	Functional	FLIPR functional assay (Ca influx activity of CHO cells)FLIPR functional assay (Ca influx activity of CHO cells)	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.6019/CHEMBL5058642
	90372616	149011	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	127045866	146815	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)ccc1F	10.1016/j.ejmech.2016.03.054
	CHEMBL3800232	146815	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)ccc1F	10.1016/j.ejmech.2016.03.054
	71460547	88495	27	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm3002026
	CHEMBL2163923	88495	27	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSAAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm3002026
	127045865	146509	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1F	10.1016/j.ejmech.2016.03.054
	CHEMBL3798274	146509	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1F	10.1016/j.ejmech.2016.03.054
	162671590	189740	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	479	12	1	4	6.5	COc1ccc(CCCC(C)(C)C)c(N2CC(COc3cccc(C(CC(=O)O)C4CC4)c3)C2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4792979	189740	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	479	12	1	4	6.5	COc1ccc(CCCC(C)(C)C)c(N2CC(COc3cccc(C(CC(=O)O)C4CC4)c3)C2)c1	10.1021/acs.jmedchem.0c00843
	90151466	163055	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	529	6	1	5	6.3	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(Cl)ccc4Cl)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4065150	163055	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	529	6	1	5	6.3	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(Cl)ccc4Cl)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	90644296	118740	0	None	-29	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	4.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(F)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288354	118740	0	None	-29	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	4.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(F)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	90644295	118739	0	None	3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(CCC(=O)O)cnc1OCc1cccc(-c2c(C)cccc2C)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288353	118739	0	None	3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(CCC(=O)O)cnc1OCc1cccc(-c2c(C)cccc2C)c1	10.1016/j.bmcl.2014.04.065
	73777156	159494	0	None	-18	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	159494	0	None	-18	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134151115	158978	0	None	-72	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	158978	0	None	-72	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	24825490	94256	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	323	6	2	2	4.6	O=C(O)CCc1ccc(NCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL233402	94256	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	323	6	2	2	4.6	O=C(O)CCc1ccc(NCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmcl.2006.12.084
	24825484	94766	0	None	208	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234269	94766	0	None	208	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	145966632	170940	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	437	7	1	6	4.2	Cc1nc(-c2cccc(Cl)c2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4210351	170940	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	437	7	1	6	4.2	Cc1nc(-c2cccc(Cl)c2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	54757624	72111	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	256	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2cccs2)cc1	10.1021/jm2005699
	CHEMBL1829155	72111	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	256	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2cccs2)cc1	10.1021/jm2005699
	71655226	97139	0	None	36	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
	CHEMBL2386357	97139	0	None	36	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
	118642384	148943	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883790	148943	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	447	7	1	4	5.9	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	145973781	171512	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	8	2	6	4.0	Cc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c(C)c1	10.1016/j.ejmech.2017.09.019
	CHEMBL4217530	171512	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	411	8	2	6	4.0	Cc1ccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c(C)c1	10.1016/j.ejmech.2017.09.019
	90151537	163226	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	479	6	1	5	5.1	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccc(F)cc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4067111	163226	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	479	6	1	5	5.1	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccc(F)cc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	137645353	167993	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	544	12	1	6	5.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3cccnc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4083311	167993	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	544	12	1	6	5.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3cccnc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4117885	167993	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	544	12	1	6	5.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3cccnc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	118642372	169243	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	429	7	1	4	5.8	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4166943	169243	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	429	7	1	4	5.8	COc1cc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	145965138	171240	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	400	7	1	4	3.9	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3F)c2)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4214028	171240	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	400	7	1	4	3.9	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3F)c2)cc1	10.1016/j.ejmech.2017.07.001
	75511308	129284	2	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	330	7	1	6	3.4	O=C(O)CCc1ccc(OCc2nc(-c3cccs3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601052	129284	2	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	330	7	1	6	3.4	O=C(O)CCc1ccc(OCc2nc(-c3cccs3)no2)cc1	10.1016/j.bmcl.2015.06.018
	46231781	207585	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	436	4	1	5	5.1	O=C1NC(=O)C(Cc2ccc(Oc3ncc(C(F)(F)F)cc3Cl)cc2Cl)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL600800	207585	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	436	4	1	5	5.1	O=C1NC(=O)C(Cc2ccc(Oc3ncc(C(F)(F)F)cc3Cl)cc2Cl)S1	10.1016/j.bmcl.2009.10.052
	121294363	189859	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	599	12	1	6	7.0	COc1ccc(C(=O)N(CC(C)(C)C)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4794401	189859	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	599	12	1	6	7.0	COc1ccc(C(=O)N(CC(C)(C)C)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	71460547	88495	27	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm3002026
	CHEMBL2163923	88495	27	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm3002026
	23157282	83995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2048628	83995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2079469	83995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	131986182	171400	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cc(OCCOC)ccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4216026	171400	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cc(OCCOC)ccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	23136411	65606	0	None	11	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm101405t
	CHEMBL1688457	65606	0	None	11	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm101405t
	51349991	65628	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	376	10	1	3	4.9	O=C(O)CCc1ccc(OCc2cccc(OCCc3ccccc3)c2)cc1	10.1021/jm101405t
	CHEMBL1688478	65628	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	376	10	1	3	4.9	O=C(O)CCc1ccc(OCc2cccc(OCCc3ccccc3)c2)cc1	10.1021/jm101405t
	44572095	21684	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	402	6	1	5	4.0	Cc1cccc(C)c1-c1cccc(COc2ccc(Cn3oc(=O)[nH]c3=O)cc2)c1	10.1016/j.bmcl.2008.10.085
	CHEMBL1208013	21684	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	402	6	1	5	4.0	Cc1cccc(C)c1-c1cccc(COc2ccc(Cn3oc(=O)[nH]c3=O)cc2)c1	10.1016/j.bmcl.2008.10.085
	CHEMBL475053	21684	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	402	6	1	5	4.0	Cc1cccc(C)c1-c1cccc(COc2ccc(Cn3oc(=O)[nH]c3=O)cc2)c1	10.1016/j.bmcl.2008.10.085
	168284831	198071	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	396	8	1	4	4.9	COc1ccc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5190883	198071	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	396	8	1	4	4.9	COc1ccc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	42603138	76791	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939643	76791	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	137630491	167859	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	558	12	1	6	6.2	Cc1cccc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)n1	10.1016/j.ejmech.2017.01.005
	CHEMBL4098843	167859	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	558	12	1	6	6.2	Cc1cccc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)n1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116766	167859	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	558	12	1	6	6.2	Cc1cccc(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)n1	10.1016/j.ejmech.2017.01.005
	137635715	162855	0	None	9	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1cccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4062765	162855	0	None	9	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1cccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01559
	137638184	163535	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	6	1	3	4.6	O=C(O)C[C@@H]1CCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4070619	163535	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	6	1	3	4.6	O=C(O)C[C@@H]1CCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	145981983	173448	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4281717	173448	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	118737974	125914	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@H](CC(=O)O)c1ccc(O[C@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	CHEMBL3427715	125914	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@H](CC(=O)O)c1ccc(O[C@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	137642248	164932	0	None	1	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	CHEMBL4087308	164932	0	None	1	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	137641818	164986	0	None	-10	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4087992	164986	0	None	-10	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137643731	165165	0	None	-5	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4089919	165165	0	None	-5	2	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	90151624	162924	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	462	6	1	6	4.3	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccccn4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4063627	162924	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	462	6	1	6	4.3	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccccn4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	46231714	207800	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1cccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)n1	10.1016/j.bmcl.2009.10.052
	CHEMBL602289	207800	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1cccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)n1	10.1016/j.bmcl.2009.10.052
	71562772	93307	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	305	5	1	3	3.0	N#CCOc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315531	93307	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	305	5	1	3	3.0	N#CCOc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	51350272	65615	0	None	107	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1688465	65615	0	None	107	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	75511299	129285	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	324	7	1	5	3.3	O=C(O)CCc1ccc(OCc2noc(-c3ccccc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601053	129285	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	324	7	1	5	3.3	O=C(O)CCc1ccc(OCc2noc(-c3ccccc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	53248848	68942	0	None	-2	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777876	68942	0	None	-2	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	75511306	129286	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	354	8	1	6	3.3	COc1cccc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)c1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601054	129286	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	354	8	1	6	3.3	COc1cccc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)c1	10.1016/j.bmcl.2015.06.018
	145977404	170626	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	401	7	1	6	3.4	Cc1noc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4206505	170626	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	401	7	1	6	3.4	Cc1noc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	51350272	65615	0	None	107	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688465	65615	0	None	107	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	24857286	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b01357
	6484	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b01357
	CHEMBL1829174	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b01357
	DB12491	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b01357
	58172979	129444	2	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	367	8	2	3	5.2	CCOC(CC(=O)O)c1ccc(NCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604033	129444	2	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	367	8	2	3	5.2	CCOC(CC(=O)O)c1ccc(NCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	23111704	80822	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022244	80822	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/jm2012968
	23111781	80825	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022247	80825	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
	145968204	171966	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	379	6	1	5	4.5	Cc1noc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4228620	171966	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	379	6	1	5	4.5	Cc1noc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	24857286	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2016.03.054
	6484	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2016.03.054
	CHEMBL1829174	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2016.03.054
	DB12491	8405	72	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2016.03.054
	168271964	196888	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	432	8	1	4	5.7	COc1ccc2cc(-c3cccc(COc4ccc(OCC(=O)O)c(F)c4)c3)ccc2c1	10.1016/j.bmc.2022.116615
	CHEMBL5173019	196888	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	432	8	1	4	5.7	COc1ccc2cc(-c3cccc(COc4ccc(OCC(=O)O)c(F)c4)c3)ccc2c1	10.1016/j.bmc.2022.116615
	57414403	82390	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047153	82390	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
	146314264	189096	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	423	9	1	4	5.3	COc1ccc(C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4784293	189096	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	423	9	1	4	5.3	COc1ccc(C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	58218726	165917	0	None	-3	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(C)c1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4097951	165917	0	None	-3	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(C)c1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	23159839	65629	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	333	7	1	3	4.3	O=C(O)CCc1ccc(OCc2cccc(-c3ccccn3)c2)cc1	10.1021/jm101405t
	CHEMBL1688479	65629	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	333	7	1	3	4.3	O=C(O)CCc1ccc(OCc2cccc(-c3ccccn3)c2)cc1	10.1021/jm101405t
	23159846	65631	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	339	7	1	4	4.4	O=C(O)CCc1ccc(OCc2cccc(-c3nccs3)c2)cc1	10.1021/jm101405t
	CHEMBL1688481	65631	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	339	7	1	4	4.4	O=C(O)CCc1ccc(OCc2cccc(-c3nccs3)c2)cc1	10.1021/jm101405t
	57391959	76797	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	362	6	1	2	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939649	76797	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	362	6	1	2	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmcl.2011.10.118
	137635143	163033	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3C(F)(F)F)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4064922	163033	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3C(F)(F)F)c2)s1	10.1021/acs.jmedchem.6b01357
	145977043	170412	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	491	9	2	5	5.8	O=C(O)CCc1ccc(NC(=O)c2nnc(CC(c3ccccc3)c3ccc(Cl)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4203929	170412	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	491	9	2	5	5.8	O=C(O)CCc1ccc(NC(=O)c2nnc(CC(c3ccccc3)c3ccc(Cl)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	145979329	173505	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	430	7	1	6	2.9	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(S(C)(=O)=O)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4283015	173505	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	430	7	1	6	2.9	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(S(C)(=O)=O)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	145976136	170574	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2cccc(F)c2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4205991	170574	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2cccc(F)c2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	54757622	72109	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	300	3	1	3	2.9	Cc1cc(C#Cc2ccc(CCC(=O)O)cc2)nc(Cl)n1	10.1021/jm2005699
	CHEMBL1829153	72109	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	300	3	1	3	2.9	Cc1cc(C#Cc2ccc(CCC(=O)O)cc2)nc(Cl)n1	10.1021/jm2005699
	145990303	173804	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	404	9	1	4	5.2	O=C(O)CC1COc2cc(OCCCOc3cccc(-c4ccccc4)c3)ccc21	10.1016/j.ejmech.2018.09.071
	CHEMBL4288513	173804	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	404	9	1	4	5.2	O=C(O)CC1COc2cc(OCCCOc3cccc(-c4ccccc4)c3)ccc21	10.1016/j.ejmech.2018.09.071
	131986113	171604	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	590	7	1	5	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(I)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218709	171604	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	590	7	1	5	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(I)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	23111668	80821	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/ml1000855
	CHEMBL2022243	80821	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/ml1000855
	23111682	80877	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	494	9	1	4	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022576	80877	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	494	9	1	4	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
	23111734	80878	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022577	80878	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	145953365	169240	0	None	1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4166892	169240	0	None	1	3	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40Agonist activity at rat GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	155549083	180447	0	None	-6	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4534836	180447	0	None	-6	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	118645789	186836	0	None	-11	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	478	12	1	5	6.2	CCCCc1nc(COc2cccc([C@@H](CC(=O)O)C3CC3)c2)cnc1-c1cc(OC)ccc1F	10.1016/j.bmcl.2018.01.013
	CHEMBL4747793	186836	0	None	-11	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	478	12	1	5	6.2	CCCCc1nc(COc2cccc([C@@H](CC(=O)O)C3CC3)c2)cnc1-c1cc(OC)ccc1F	10.1016/j.bmcl.2018.01.013
	1050	8683	94	None	-1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	11595431	8683	94	None	-1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	CHEMBL207881	8683	94	None	-1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	131842087	171626	29	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	416	7	1	4	4.4	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4218946	171626	29	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	416	7	1	4	4.4	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.ejmech.2017.07.001
	1050	8683	94	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/ml100106c
	11595431	8683	94	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/ml100106c
	CHEMBL207881	8683	94	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/ml100106c
	145947987	174513	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	351	7	1	4	4.6	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2019.04.019
	CHEMBL4228673	174513	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	351	7	1	4	4.6	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2019.04.019
	CHEMBL4302779	174513	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	351	7	1	4	4.6	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2019.04.019
	134136960	161246	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	543	11	1	5	6.3	COc1ccc(CC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3893207	161246	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	543	11	1	5	6.3	COc1ccc(CC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990279	161246	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	543	11	1	5	6.3	COc1ccc(CC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)cc1	10.1016/j.bmc.2016.09.004
	90151023	164995	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	538	8	1	7	5.1	CCOc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(F)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4088102	164995	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	538	8	1	7	5.1	CCOc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(F)cn1	10.1021/acs.jmedchem.7b00982
	145993644	174108	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	410	8	1	5	4.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(OC(C)C)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4294274	174108	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	410	8	1	5	4.3	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(OC(C)C)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	132578495	189665	2	None	-13	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4792027	189665	2	None	-13	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	71612897	96758	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	552	9	1	7	5.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381294	96758	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	552	9	1	7	5.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	54580626	68940	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777874	68940	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
	75202601	165163	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	482	7	1	5	4.7	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4089881	165163	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	482	7	1	5	4.7	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C2)c1	10.1021/acs.jmedchem.7b00982
	145988554	174038	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	412	5	1	3	5.3	O=C(O)C#Cc1ccc(OCc2cccc(-c3ccccc3OC(F)(F)F)c2)cc1	10.1016/j.ejmech.2018.08.075
	CHEMBL4292911	174038	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	412	5	1	3	5.3	O=C(O)C#Cc1ccc(OCc2cccc(-c3ccccc3OC(F)(F)F)c2)cc1	10.1016/j.ejmech.2018.08.075
	145987167	173991	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	370	4	1	2	5.3	Cc1cc(C)c(-c2cccc(COc3ccc(C#CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2018.08.075
	CHEMBL4291858	173991	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	370	4	1	2	5.3	Cc1cc(C)c(-c2cccc(COc3ccc(C#CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2018.08.075
	145975628	170554	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	382	7	1	4	3.8	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4205774	170554	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	382	7	1	4	3.8	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.ejmech.2017.07.001
	11316164	83564	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	422	7	2	5	5.2	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(OCC(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL206881	83564	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	422	7	2	5	5.2	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(OCC(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	1049	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	4618	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	5280934	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	CHEMBL8739	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	DB00132	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	145974295	169804	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	518	9	1	6	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(OC)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4175826	169804	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	518	9	1	6	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(OC)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	57414678	82401	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	564	8	1	6	6.1	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OC1CCS(=O)(=O)CC1	10.1021/jm300170m
	CHEMBL2047165	82401	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	564	8	1	6	6.1	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OC1CCS(=O)(=O)CC1	10.1021/jm300170m
	131986132	170638	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	554	11	3	8	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206640	170638	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	554	11	3	8	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	45107318	125908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	340	7	1	3	4.6	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C)cccc32)cc1	10.1021/ml500391n
	CHEMBL3427709	125908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	340	7	1	3	4.6	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C)cccc32)cc1	10.1021/ml500391n
	45107318	125908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	340	7	1	3	4.6	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427709	125908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	340	7	1	3	4.6	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(C)cccc32)cc1	10.1016/j.bmc.2015.07.028
	121294254	186909	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	585	13	1	6	6.7	COc1ccc(C(=O)N(CC(C)C)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4748739	186909	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	585	13	1	6	6.7	COc1ccc(C(=O)N(CC(C)C)c2ccccn2)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	12002201	82610	1	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	555	10	3	6	5.1	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL2048627	82610	1	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	555	10	3	6	5.1	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	23111689	80835	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	388	6	1	3	5.5	Cc1ccc(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022257	80835	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	388	6	1	3	5.5	Cc1ccc(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	90372365	148920	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	8	1	4	7.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2OC(F)(F)F)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883504	148920	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	8	1	4	7.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2OC(F)(F)F)c1	10.1021/acsmedchemlett.6b00443
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.09.010
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.09.010
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.09.010
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.09.010
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2016.03.014
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2016.03.014
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2016.03.014
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2016.03.014
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.10.011
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.10.011
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.10.011
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2015.10.011
	155552554	180839	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	512	8	1	5	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(OC(F)(F)F)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4544058	180839	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	512	8	1	5	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(OC(F)(F)F)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	57414268	82387	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	CHEMBL2047150	82387	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	57414538	82393	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047156	82393	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
	137646830	164786	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	331	5	1	3	4.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4085420	164786	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	331	5	1	3	4.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.6b01559
	58172957	118437	0	None	1	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3286417	118437	0	None	1	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmcl.2014.04.065
	145986046	172691	0	None	-19	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250196	172691	0	None	-19	2	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	44634024	72115	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	285	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2ccnc(Cl)c2)cc1	10.1021/jm2005699
	CHEMBL1829159	72115	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	285	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2ccnc(Cl)c2)cc1	10.1021/jm2005699
	134139171	153041	0	None	-104	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	153041	0	None	-104	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	134130787	149044	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	471	7	1	4	6.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C#N)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884916	149044	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	471	7	1	4	6.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C#N)c1	10.1021/acsmedchemlett.6b00443
	71257551	157372	24	None	-14	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL3955132	157372	24	None	-14	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.7b01411
	91801188	176354	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4435837	176354	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2F)c1	10.1016/j.bmcl.2019.04.050
	155565379	182345	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c(F)cn1	10.1016/j.bmcl.2019.04.050
	CHEMBL4579146	182345	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c(F)cn1	10.1016/j.bmcl.2019.04.050
	134465794	177857	0	None	-4	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4457303	177857	0	None	-4	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	118637996	148948	0	None	-15	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883819	148948	0	None	-15	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4162778	148948	0	None	-15	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.8b00149
	118637996	148948	0	None	-15	2	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883819	148948	0	None	-15	2	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL4162778	148948	0	None	-15	2	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	59590781	118029	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	517	8	1	4	7.4	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265147	118029	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	517	8	1	4	7.4	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
	90644286	118730	0	None	10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288344	118730	0	None	10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	57706778	87572	29	None	-8	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL2152070	87572	29	None	-8	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	67087173	189239	0	None	-8	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4786335	189239	0	None	-8	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	24897670	118581	23	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ccon2)cc1	10.1021/ml400501x
	CHEMBL3287574	118581	23	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ccon2)cc1	10.1021/ml400501x
	45107312	125911	5	None	2	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	CHEMBL3427712	125911	5	None	2	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	45107312	125911	5	None	2	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427712	125911	5	None	2	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1016/j.bmc.2015.07.028
	90644290	118734	0	None	4	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2cnc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288348	118734	0	None	4	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2cnc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	15602772	118580	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	503	8	1	8	4.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nnnn2C)cc1	10.1021/ml400501x
	CHEMBL3287573	118580	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	503	8	1	8	4.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nnnn2C)cc1	10.1021/ml400501x
	45107282	125902	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1021/ml500391n
	CHEMBL3427703	125902	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1021/ml500391n
	45107282	125902	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427703	125902	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	118144982	177131	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2F)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4447353	177131	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2F)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	51350139	65624	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	7	1	2	5.9	Cc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ccc1CCC(=O)O	10.1021/jm101405t
	CHEMBL1688474	65624	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	7	1	2	5.9	Cc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ccc1CCC(=O)O	10.1021/jm101405t
	51350140	65625	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ccc1CCC(=O)O	10.1021/jm101405t
	CHEMBL1688475	65625	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ccc1CCC(=O)O	10.1021/jm101405t
	51350405	65635	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	8	1	2	6.1	CC(C)c1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688485	65635	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	8	1	2	6.1	CC(C)c1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	23111734	80878	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	CHEMBL2022577	80878	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
	131986035	170836	0	None	-5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	612	10	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4209136	170836	0	None	-5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	612	10	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	122185435	129452	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	318	8	1	3	4.0	CCOC(CC(=O)O)c1ccc(OCc2cccc(F)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604040	129452	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	318	8	1	3	4.0	CCOC(CC(=O)O)c1ccc(OCc2cccc(F)c2)cc1	10.1016/j.bmc.2015.07.028
	51350138	65623	0	None	660	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL1688473	65623	0	None	660	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	131986057	170434	0	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4204345	170434	0	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	482	7	1	5	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	118638001	148898	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883355	148898	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	71613312	96770	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1cccc(C)c1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381306	96770	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1cccc(C)c1-c1cccc([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	71613521	96754	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.2	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381290	96754	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	380	3	1	4	4.2	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	51349860	65602	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm101405t
	CHEMBL1688453	65602	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm101405t
	51349990	65627	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	9	1	3	4.9	O=C(O)CCc1ccc(OCc2cccc(OCc3ccccc3)c2)cc1	10.1021/jm101405t
	CHEMBL1688477	65627	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	9	1	3	4.9	O=C(O)CCc1ccc(OCc2cccc(OCc3ccccc3)c2)cc1	10.1021/jm101405t
	86803193	129237	5	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	338	7	1	5	3.6	Cc1ccc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601001	129237	5	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	338	7	1	5	3.6	Cc1ccc(-c2noc(COc3ccc(CCC(=O)O)cc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	155569570	182980	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	496	7	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)c(Cl)c4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4593742	182980	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	496	7	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)c(Cl)c4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	75511316	129287	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	388	8	1	6	4.0	COc1cccc(-c2noc(COc3ccc(CCC(=O)O)cc3Cl)n2)c1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601055	129287	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	388	8	1	6	4.0	COc1cccc(-c2noc(COc3ccc(CCC(=O)O)cc3Cl)n2)c1	10.1016/j.bmcl.2015.06.018
	1049	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	4618	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	5280934	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	CHEMBL8739	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	DB00132	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	85472225	169540	0	None	-64	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 by calcium flux assayAgonist activity at human GPR40 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	169540	0	None	-64	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 by calcium flux assayAgonist activity at human GPR40 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	67085353	166014	0	None	-9	2	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	435	7	1	4	6.0	COc1ccc(F)c(-c2cccc(Oc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4098892	166014	0	None	-9	2	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	435	7	1	4	6.0	COc1ccc(F)c(-c2cccc(Oc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	145947309	174456	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	491	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4241974	174456	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	491	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4302072	174456	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	491	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	145965968	171025	0	None	4	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	480	7	1	5	6.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3c(c2)c(-c2ccccc2C)c[s+]3[O-])cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4211335	171025	0	None	4	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	480	7	1	5	6.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3c(c2)c(-c2ccccc2C)c[s+]3[O-])cc1	10.1016/j.bmcl.2017.12.022
	86803219	129291	2	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	426	7	1	5	5.0	O=C(O)CCc1ccc(OCc2nc(-c3cccc(C(F)(F)F)c3)no2)c(Cl)c1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601059	129291	2	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	426	7	1	5	5.0	O=C(O)CCc1ccc(OCc2nc(-c3cccc(C(F)(F)F)c3)no2)c(Cl)c1	10.1016/j.bmcl.2015.06.018
	24860552	150066	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	312	8	1	2	4.7	CC[C@H](C)COc1ccc(C(CC(=O)O)c2ccccc2)cc1	10.1021/jm2005699
	CHEMBL389699	150066	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	312	8	1	2	4.7	CC[C@H](C)COc1ccc(C(CC(=O)O)c2ccccc2)cc1	10.1021/jm2005699
	11750823	83608	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@@H]2C[C@@H]2C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL206942	83608	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@@H]2C[C@@H]2C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	145980573	173370	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	384	8	1	4	4.8	CC(C)(C)c1cccc(OCCCOc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.ejmech.2018.09.071
	CHEMBL4280212	173370	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	384	8	1	4	4.8	CC(C)(C)c1cccc(OCCCOc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.ejmech.2018.09.071
	118642391	169741	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	429	7	1	4	5.8	COc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)n1	10.1021/acsmedchemlett.8b00149
	CHEMBL4174833	169741	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	429	7	1	4	5.8	COc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)n1	10.1021/acsmedchemlett.8b00149
	53248847	68921	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	CHEMBL1777855	68921	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	90151464	162715	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	519	7	1	6	5.6	COc1cc(C)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c(C)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4061053	162715	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	519	7	1	6	5.6	COc1cc(C)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c(C)c1	10.1021/acs.jmedchem.7b00982
	145986662	173952	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	428	7	1	6	3.9	Cn1cncc1C(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4291179	173952	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	428	7	1	6	3.9	Cn1cncc1C(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	12830931	209223	3	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	299	4	1	4	3.4	O=C1NC(=O)C(Cc2ccc(Oc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL611065	209223	3	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	299	4	1	4	3.4	O=C1NC(=O)C(Cc2ccc(Oc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	145984906	173171	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	362	8	1	4	4.1	O=C(O)CC1COc2cc(OCCCOc3cccc(Cl)c3)ccc21	10.1016/j.ejmech.2018.09.071
	CHEMBL4276781	173171	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	362	8	1	4	4.1	O=C(O)CC1COc2cc(OCCCOc3cccc(Cl)c3)ccc21	10.1016/j.ejmech.2018.09.071
	145955179	169189	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	490	8	1	5	4.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)o2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4166005	169189	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	490	8	1	5	4.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)o2)cc1	10.1016/j.ejmech.2018.04.023
	71562422	93316	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	Cc1ccc(C#Cc2ccc([C@H]3C[C@@H]3C(=O)O)cc2)cc1	10.1021/jm301470a
	CHEMBL2315540	93316	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	Cc1ccc(C#Cc2ccc([C@H]3C[C@@H]3C(=O)O)cc2)cc1	10.1021/jm301470a
	145974478	171466	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	451	8	2	6	4.4	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3cccc(C(F)(F)F)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4217082	171466	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	451	8	2	6	4.4	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3cccc(C(F)(F)F)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	58172986	125904	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1021/ml500391n
	CHEMBL3427705	125904	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1021/ml500391n
	58172986	125904	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427705	125904	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmc.2015.07.028
	54586486	68936	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	320	5	1	2	4.3	CC#CC(CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777870	68936	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	320	5	1	2	4.3	CC#CC(CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmcl.2011.03.114
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	57413375	83994	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
	CHEMBL2048620	83994	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
	CHEMBL2079468	83994	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
	145950347	169617	0	None	-1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	506	8	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4172828	169617	0	None	-1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	506	8	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	118645541	187422	0	None	-4	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	526	10	1	5	7.1	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2-c2cc(C)cc(C)c2)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4754974	187422	0	None	-4	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	526	10	1	5	7.1	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2-c2cc(C)cc(C)c2)c1	10.1016/j.bmcl.2018.01.013
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.12.030
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.12.030
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.12.030
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.12.030
	51349861	65603	0	None	77	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm101405t
	CHEMBL1688454	65603	0	None	77	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm101405t
	57706502	171094	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4212284	171094	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	67085353	166014	0	None	9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	435	7	1	4	6.0	COc1ccc(F)c(-c2cccc(Oc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4098892	166014	0	None	9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	435	7	1	4	6.0	COc1ccc(F)c(-c2cccc(Oc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	87265393	166060	0	None	4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	5	1	3	5.7	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2C(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4099410	166060	0	None	4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	433	5	1	3	5.7	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2C(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	90644291	118735	0	None	1	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288349	118735	0	None	1	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nn2)c1	10.1016/j.bmcl.2014.04.065
	58172988	129447	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	413	9	1	5	5.0	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c([N+](=O)[O-])c1	10.1016/j.bmc.2015.07.028
	CHEMBL3604036	129447	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	413	9	1	5	5.0	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c([N+](=O)[O-])c1	10.1016/j.bmc.2015.07.028
	90372458	149002	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	500	7	1	3	7.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc(CCC(=O)O)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884347	149002	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	500	7	1	3	7.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc(CCC(=O)O)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	54757739	72123	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	325	5	1	2	3.9	C=CCc1c(C#Cc2ccc(CCC(=O)O)cc2)ccnc1Cl	10.1021/jm2005699
	CHEMBL1829167	72123	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	325	5	1	2	3.9	C=CCc1c(C#Cc2ccc(CCC(=O)O)cc2)ccnc1Cl	10.1021/jm2005699
	24825481	82700	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	361	9	2	3	5.5	O=C(O)CCCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL205090	82700	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	361	9	2	3	5.5	O=C(O)CCCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	1049	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	4618	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	5280934	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	CHEMBL8739	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	DB00132	7151	75	None	1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/acs.jmedchem.5b01962
	12830934	209177	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	333	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3cccc(Cl)c3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL610787	209177	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	333	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3cccc(Cl)c3)cc2)S1	10.1016/j.bmcl.2009.10.052
	134133675	150040	0	None	-22	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	150040	0	None	-22	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	51350137	65622	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	7	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C)CC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688472	65622	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	374	7	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C)CC(=O)O)cc2)c1	10.1021/jm101405t
	25150014	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm8010178
	3952	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm8010178
	CHEMBL449588	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm8010178
	90644288	118732	0	None	20	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)s2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL3288346	118732	0	None	20	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)s2)c1	10.1021/acs.jmedchem.6b01357
	11489259	82604	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	519	12	1	4	6.1	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	CHEMBL2048621	82604	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	519	12	1	4	6.1	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
	162674654	190234	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4798993	190234	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
	131986082	170933	0	None	2	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	454	7	1	7	4.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccnn4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4210243	170933	0	None	2	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	454	7	1	7	4.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccnn4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986378	171360	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	552	11	1	7	6.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4215544	171360	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	552	11	1	7	6.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	118645685	186647	0	None	-15	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	492	10	1	5	6.4	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4745513	186647	0	None	-15	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	492	10	1	5	6.4	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1	10.1016/j.bmcl.2018.01.013
	25150014	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm8010178
	3952	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm8010178
	CHEMBL449588	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm8010178
	127046960	146769	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2019.04.019
	CHEMBL3799946	146769	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2019.04.019
	CHEMBL4227915	146769	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2019.04.019
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.07.050
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.07.050
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.07.050
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.07.050
	51351414	65618	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	358	7	1	1	5.8	Cc1cccc(C)c1-c1cccc(CCc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688468	65618	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	358	7	1	1	5.8	Cc1cccc(C)c1-c1cccc(CCc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	90161101	165565	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	540	7	1	7	5.3	COc1cc(N2CC[C@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@@H](C)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4094183	165565	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	540	7	1	7	5.3	COc1cc(N2CC[C@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@@H](C)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	90644300	118744	0	None	-31	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288358	118744	0	None	-31	2	Rat	6.5	pEC50	=	6.5	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(C(C)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	1622278	101779	10	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Activity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	CHEMBL254861	101779	10	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Activity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	22036572	172079	73	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	242	5	1	2	3.5	O=C(O)CCc1ccc(Oc2ccccc2)cc1	10.1021/jm101405t
	CHEMBL423319	172079	73	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	242	5	1	2	3.5	O=C(O)CCc1ccc(Oc2ccccc2)cc1	10.1021/jm101405t
	57397248	76786	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	314	8	1	3	4.2	CCC(CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939638	76786	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	314	8	1	3	4.2	CCC(CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	122185442	129463	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	318	8	1	5	2.9	CCOC(CC(=O)O)c1ccc(OCc2cc(C)nn2C)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604051	129463	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	318	8	1	5	2.9	CCOC(CC(=O)O)c1ccc(OCc2cc(C)nn2C)cc1	10.1016/j.bmc.2015.07.028
	58218581	165903	0	None	-8	2	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	5	1	3	5.2	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4097826	165903	0	None	-8	2	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	5	1	3	5.2	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	137640417	163880	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	351	7	1	5	3.6	Cc1cccc(C)c1-c1cccc(OCn2cc(CCC(=O)O)nn2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4074547	163880	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	351	7	1	5	3.6	Cc1cccc(C)c1-c1cccc(OCn2cc(CCC(=O)O)nn2)c1	10.1021/acs.jmedchem.6b01357
	44409697	83496	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	365	8	2	4	5.3	O=C(O)CSc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL206572	83496	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	365	8	2	4	5.3	O=C(O)CSc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	168283014	197655	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	393	7	1	5	4.7	O=C(O)COc1ccc(OCc2cccc(-c3ccc4ncoc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	CHEMBL5184830	197655	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	393	7	1	5	4.7	O=C(O)COc1ccc(OCc2cccc(-c3ccc4ncoc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	155527626	178010	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	554	9	1	3	9.0	COc1ccc(F)c(-c2ccc3c(c2C2=CCCC2(C)C)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4459709	178010	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	554	9	1	3	9.0	COc1ccc(F)c(-c2ccc3c(c2C2=CCCC2(C)C)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	145966219	171076	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	397	8	2	6	3.7	Cc1cccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.ejmech.2017.09.019
	CHEMBL4212106	171076	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	397	8	2	6	3.7	Cc1cccc(OCc2nnc(C(=O)Nc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.ejmech.2017.09.019
	118638009	174432	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4160527	174432	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301726	174432	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	145948007	174517	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	334	9	1	3	4.2	O=C(O)CCc1ccc(OCCCOc2cccc(Cl)c2)cc1	10.1016/j.ejmech.2018.09.071
	CHEMBL4284549	174517	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	334	9	1	3	4.2	O=C(O)CCc1ccc(OCCCOc2cccc(Cl)c2)cc1	10.1016/j.ejmech.2018.09.071
	CHEMBL4302817	174517	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	334	9	1	3	4.2	O=C(O)CCc1ccc(OCCCOc2cccc(Cl)c2)cc1	10.1016/j.ejmech.2018.09.071
	23111668	80821	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022243	80821	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/jm2012968
	23111766	80836	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	402	6	1	3	5.8	Cc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022258	80836	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	402	6	1	3	5.8	Cc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	131986113	171604	0	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	590	7	1	5	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(I)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218709	171604	0	None	-1	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	590	7	1	5	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(I)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	66562385	97143	0	None	47	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386361	97143	0	None	47	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	127046962	146714	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1cc(F)cc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3799639	146714	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	387	7	1	4	4.8	Cc1noc(C)c1-c1cc(F)cc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	24857286	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.10.040
	6484	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.10.040
	CHEMBL1829174	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.10.040
	DB12491	8405	72	None	-3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2017.10.040
	118737973	125913	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	CHEMBL3427714	125913	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	394	7	1	3	5.3	CCO[C@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1	10.1021/ml500391n
	58218651	165098	0	None	-4	2	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	5	1	3	5.0	Cc1ccccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4089171	165098	0	None	-4	2	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	5	1	3	5.0	Cc1ccccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	145965467	170945	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	403	7	1	6	3.6	Cc1nc(-c2ccccc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4210415	170945	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	403	7	1	6	3.6	Cc1nc(-c2ccccc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	54583097	68574	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	270	6	1	2	3.8	CC(Oc1ccc(CCC(=O)O)cc1)c1ccccc1	10.1021/ml100106c
	CHEMBL1773249	68574	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	270	6	1	2	3.8	CC(Oc1ccc(CCC(=O)O)cc1)c1ccccc1	10.1021/ml100106c
	118145140	182164	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cc3c(cn2)[C@H](Oc2cccc([C@H](C4CC4)[C@H](C)C(=O)O)c2)CC3)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4575265	182164	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cc3c(cn2)[C@H](Oc2cccc([C@H](C4CC4)[C@H](C)C(=O)O)c2)CC3)c1	10.1016/j.bmcl.2019.04.050
	46231545	207849	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1cccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1C	10.1016/j.bmcl.2009.10.052
	CHEMBL602731	207849	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1cccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1C	10.1016/j.bmcl.2009.10.052
	85470884	170783	2	None	-36	5	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40Agonist activity at human GPR40	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	-36	5	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40Agonist activity at human GPR40	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137630696	167879	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	612	12	1	6	6.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(C(F)(F)F)cn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4064196	167879	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	612	12	1	6	6.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(C(F)(F)F)cn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116961	167879	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	612	12	1	6	6.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(C(F)(F)F)cn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	134156096	158226	0	None	-100	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	158226	0	None	-100	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	71562526	93325	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	318	3	1	1	4.1	O=C(O)CCc1ccc(C#Cc2ccccc2C(F)(F)F)cc1	10.1021/jm301470a
	CHEMBL2315549	93325	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	318	3	1	1	4.1	O=C(O)CCc1ccc(C#Cc2ccccc2C(F)(F)F)cc1	10.1021/jm301470a
	23136363	65607	0	None	14	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm101405t
	CHEMBL1688458	65607	0	None	14	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm101405t
	146314300	188219	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	493	11	1	4	6.9	COc1ccc(CCC(C)(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4764150	188219	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	493	11	1	4	6.9	COc1ccc(CCC(C)(C)C)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	155526793	177973	0	None	-2	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	462	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(F)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4459220	177973	0	None	-2	2	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	462	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)C(F)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	71613516	96749	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	346	3	1	4	3.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381285	96749	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	346	3	1	4	3.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	46941175	68586	26	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1773261	68586	26	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	51350138	65623	0	None	660	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL1688473	65623	0	None	660	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	127031412	145505	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	407	7	1	5	4.6	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-n1c(C)ccc1C	10.1016/j.bmc.2016.03.014
	CHEMBL3780042	145505	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	407	7	1	5	4.6	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-n1c(C)ccc1C	10.1016/j.bmc.2016.03.014
	168283114	197839	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	436	10	1	4	5.6	Cc1ccc(OCC2CC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5187322	197839	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	436	10	1	4	5.6	Cc1ccc(OCC2CC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	58218630	166434	0	None	13	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4103729	166434	0	None	13	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	145978975	173342	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4279744	173342	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	58218571	164259	0	None	-17	2	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	325	6	1	3	4.0	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4079421	164259	0	None	-17	2	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	325	6	1	3	4.0	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	25261464	87573	2	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	CHEMBL2152071	87573	2	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	145992078	173785	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	406	8	1	4	4.2	O=C(O)CC1COc2cc(OCCCOc3cccc(Br)c3)ccc21	10.1016/j.ejmech.2018.09.071
	CHEMBL4288124	173785	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	406	8	1	4	4.2	O=C(O)CC1COc2cc(OCCCOc3cccc(Br)c3)ccc21	10.1016/j.ejmech.2018.09.071
	71562315	93312	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	O=C(O)CC1CCc2cc(C#Cc3ccccc3)ccc21	10.1021/jm301470a
	CHEMBL2315536	93312	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	O=C(O)CC1CCc2cc(C#Cc3ccccc3)ccc21	10.1021/jm301470a
	145983824	172518	0	None	6	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246334	172518	0	None	6	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	118642379	148897	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883354	148897	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	53248847	68921	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	CHEMBL1777855	68921	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
	23082739	65626	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	396	7	1	2	5.8	Cc1cccc(C)c1-c1cccc(COc2cc(F)c(CCC(=O)O)c(F)c2)c1	10.1021/jm101405t
	CHEMBL1688476	65626	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	396	7	1	2	5.8	Cc1cccc(C)c1-c1cccc(COc2cc(F)c(CCC(=O)O)c(F)c2)c1	10.1021/jm101405t
	90644303	118749	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2cccc(C)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3288363	118749	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2cccc(C)c2)cc1	10.1016/j.bmc.2015.07.028
	122185440	129461	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	306	8	1	3	4.2	CCOC(CC(=O)O)c1ccc(OCC2CCCCC2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604049	129461	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	306	8	1	3	4.2	CCOC(CC(=O)O)c1ccc(OCC2CCCCC2)cc1	10.1016/j.bmc.2015.07.028
	90644303	118749	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2cccc(C)c2)cc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288363	118749	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2cccc(C)c2)cc1	10.1016/j.bmcl.2014.04.065
	137333449	174388	5	None	-10	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165147	174388	5	None	-10	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301092	174388	5	None	-10	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc([C@@H]3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	90372616	149011	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	71562773	93308	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	301	3	1	2	3.3	N#CCc1ccccc1C#Cc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315532	93308	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	301	3	1	2	3.3	N#CCc1ccccc1C#Cc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1021/jm301470a
	66562286	97141	0	None	223	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	CHEMBL2386359	97141	0	None	223	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	71615667	96776	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	420	4	1	4	5.3	Cc1cc(F)ccc1-c1cccc(C2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381312	96776	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	420	4	1	4	5.3	Cc1cc(F)ccc1-c1cccc(C2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	19705952	65639	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	270	7	1	2	3.3	O=C(O)CCc1ccc(OCCc2ccccc2)cc1	10.1021/jm101405t
	CHEMBL1688489	65639	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	270	7	1	2	3.3	O=C(O)CCc1ccc(OCCc2ccccc2)cc1	10.1021/jm101405t
	23082789	65640	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	284	8	1	2	3.7	O=C(O)CCc1ccc(OCCCc2ccccc2)cc1	10.1021/jm101405t
	CHEMBL1688490	65640	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	284	8	1	2	3.7	O=C(O)CCc1ccc(OCCCc2ccccc2)cc1	10.1021/jm101405t
	145982616	172525	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	470	12	1	4	5.9	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246529	172525	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	470	12	1	4	5.9	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	58218699	166195	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	373	6	1	3	5.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4100898	166195	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	373	6	1	3	5.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
	85470884	170783	2	None	-38	5	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	-38	5	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	25150011	193468	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	278	4	1	2	2.9	O=Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL488395	193468	1	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	278	4	1	2	2.9	O=Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	44409729	146988	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	434	7	2	4	6.0	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CC(C)C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL380504	146988	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	434	7	2	4	6.0	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CC(C)C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	57521915	83047	0	None	-15	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058528	83047	0	None	-15	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	155544661	181724	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	443	8	1	4	6.0	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)ccn1	10.1016/j.bmcl.2019.04.050
	CHEMBL4565467	181724	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	443	8	1	4	6.0	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)ccn1	10.1016/j.bmcl.2019.04.050
	127027659	144448	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	391	5	1	4	3.9	O=C1NC(=O)C(Cc2ccc(OCc3cccc(Br)c3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3758549	144448	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	391	5	1	4	3.9	O=C1NC(=O)C(Cc2ccc(OCc3cccc(Br)c3)cc2)S1	10.1016/j.ejmech.2015.12.049
	134157586	160942	0	None	-123	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	160942	0	None	-123	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	145989198	174025	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	342	8	1	4	3.8	Cc1cccc(OCCCOc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.ejmech.2018.09.071
	CHEMBL4292598	174025	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	342	8	1	4	3.8	Cc1cccc(OCCCOc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.ejmech.2018.09.071
	122185453	129480	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	397	7	1	5	4.2	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2COc3c2cccc3C(F)(F)F)nc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604068	129480	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	397	7	1	5	4.2	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2COc3c2cccc3C(F)(F)F)nc1	10.1016/j.bmc.2015.07.028
	118638009	174432	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4160527	174432	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301726	174432	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	479	7	1	4	6.3	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	118623088	148905	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883407	148905	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	155549085	180448	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	425	10	3	5	4.2	Cc1cc(OCCO)ccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4534840	180448	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	425	10	3	5	4.2	Cc1cc(OCCO)ccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	145964042	170862	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	430	7	1	4	4.8	Cc1ccc(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(Cl)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4209491	170862	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	430	7	1	4	4.8	Cc1ccc(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(Cl)c1	10.1016/j.ejmech.2017.07.001
	44409933	82759	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	418	6	2	4	5.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL205434	82759	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	418	6	2	4	5.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	71612685	96755	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	352	4	1	4	4.0	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(C2CC2)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381291	96755	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	352	4	1	4	4.0	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(C2CC2)c1)O3	10.1016/j.bmcl.2013.03.060
	155535186	178787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	369	7	2	3	4.7	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3F)c2)cc1F	10.1016/j.ejmech.2019.06.087
	CHEMBL4471403	178787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	369	7	2	3	4.7	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3F)c2)cc1F	10.1016/j.ejmech.2019.06.087
	168276253	197232	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	396	9	1	4	4.9	CCOc1ccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.bmc.2022.116615
	CHEMBL5178528	197232	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	396	9	1	4	4.9	CCOc1ccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.bmc.2022.116615
	67058186	125903	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1021/ml500391n
	CHEMBL3427704	125903	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1021/ml500391n
	57394144	76626	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	356	6	1	2	5.7	CC#CC(CC(=O)O)c1ccc(Oc2cccc(-c3ccccc3)c2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1938409	76626	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	356	6	1	2	5.7	CC#CC(CC(=O)O)c1ccc(Oc2cccc(-c3ccccc3)c2)cc1	10.1016/j.bmcl.2011.10.118
	67058186	125903	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427704	125903	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCO[C@H](CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	58218581	165903	0	None	8	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	5	1	3	5.2	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4097826	165903	0	None	8	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	5	1	3	5.2	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	90151400	162914	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	513	6	1	5	5.7	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(F)ccc4Cl)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4063492	162914	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	513	6	1	5	5.7	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(F)ccc4Cl)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	90151222	163684	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	6	1	5	5.9	Cc1ccc(Cl)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4072229	163684	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	6	1	5	5.9	Cc1ccc(Cl)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	132578495	189665	2	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4792027	189665	2	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	23136477	65604	3	None	-15	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm101405t
	CHEMBL1688455	65604	3	None	-15	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm101405t
	CHEMBL4213909	65604	3	None	-15	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm101405t
	853224	101350	11	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	CHEMBL251963	101350	11	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	134154473	159153	0	None	-218	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3970238	159153	0	None	-218	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	1051	8237	63	None	-14	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/ml300133f
	4289	8237	63	None	-14	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/ml300133f
	445580	8237	63	None	-14	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/ml300133f
	57417355	8237	63	None	-14	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/ml300133f
	CHEMBL367149	8237	63	None	-14	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/ml300133f
	DB03756	8237	63	None	-14	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	10.1021/ml300133f
	90151309	162723	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	7	1	6	5.1	COc1ccc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)cc1F	10.1021/acs.jmedchem.7b00982
	CHEMBL4061146	162723	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	7	1	6	5.1	COc1ccc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)cc1F	10.1021/acs.jmedchem.7b00982
	145979602	173291	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	466	11	1	6	3.4	CS(=O)(=O)CCCOc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CC2	10.1016/j.bmc.2018.10.019
	CHEMBL4278799	173291	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	466	11	1	6	3.4	CS(=O)(=O)CCCOc1ccc2c(c1)OC(COc1ccc(CCC(=O)O)c(F)c1)CC2	10.1016/j.bmc.2018.10.019
	145977668	170658	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	415	7	1	6	3.7	Cc1noc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1C	10.1016/j.ejmech.2017.07.001
	CHEMBL4206915	170658	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	415	7	1	6	3.7	Cc1noc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1C	10.1016/j.ejmech.2017.07.001
	73345870	97151	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386369	97151	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	54586982	68573	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	254	6	1	1	3.5	O=C(O)CCc1ccc(CCc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1773248	68573	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	254	6	1	1	3.5	O=C(O)CCc1ccc(CCc2ccccc2)cc1	10.1021/ml100106c
	145974382	171319	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	367	7	2	5	3.4	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3ccccc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4215054	171319	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	367	7	2	5	3.4	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3ccccc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	127051975	147071	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	417	8	2	6	4.0	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccc(Cl)cc3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805971	147071	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	417	8	2	6	4.0	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccc(Cl)cc3)s2)cc1	10.1016/j.bmc.2016.04.065
	131986075	170688	0	None	-2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	466	7	1	7	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4207273	170688	0	None	-2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	466	7	1	7	5.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	118645367	188441	0	None	5	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4776217	188441	0	None	5	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	24857286	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2019.06.087
	6484	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2019.06.087
	CHEMBL1829174	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2019.06.087
	DB12491	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2019.06.087
	66562289	145797	0	None	707	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785764	145797	0	None	707	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	127046960	146769	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2019.04.019
	CHEMBL3799946	146769	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2019.04.019
	CHEMBL4227915	146769	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 1 hr by Fluo 4-AM dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2019.04.019
	142738567	169321	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	299	4	2	1	4.5	O=C(O)CCc1ccc2[nH]c(-c3cccc(Cl)c3)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4168059	169321	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	299	4	2	1	4.5	O=C(O)CCc1ccc2[nH]c(-c3cccc(Cl)c3)cc2c1	10.1021/acsmedchemlett.7b00460
	58380220	118033	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	520	8	1	6	5.9	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265151	118033	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	520	8	1	6	5.9	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
	57706588	87445	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	476	9	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151298	87445	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	476	9	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	58172957	118437	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3286417	118437	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmc.2015.07.028
	58172957	118437	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3286417	118437	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(C)cc2)cc1	10.1016/j.bmcl.2014.04.065
	90151283	166262	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	494	6	1	6	4.8	Cc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)n1	10.1021/acs.jmedchem.7b00982
	CHEMBL4101678	166262	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	494	6	1	6	4.8	Cc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)n1	10.1021/acs.jmedchem.7b00982
	54585512	68937	0	None	-1	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	335	5	1	4	3.0	CC#CC(c1ccc(OCc2ccccc2)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777871	68937	0	None	-1	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	335	5	1	4	3.0	CC#CC(c1ccc(OCc2ccccc2)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	73348895	97154	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386371	97154	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	25150018	192211	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	266	3	1	2	2.9	Cc1ccccc1C#Cc1ccc(OCC(=O)O)cc1	10.1016/j.ejmech.2019.06.087
	CHEMBL486145	192211	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	266	3	1	2	2.9	Cc1ccccc1C#Cc1ccc(OCC(=O)O)cc1	10.1016/j.ejmech.2019.06.087
	25150018	192211	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	266	3	1	2	2.9	Cc1ccccc1C#Cc1ccc(OCC(=O)O)cc1	10.1021/jm8010178
	CHEMBL486145	192211	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	266	3	1	2	2.9	Cc1ccccc1C#Cc1ccc(OCC(=O)O)cc1	10.1021/jm8010178
	145990731	173799	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	328	4	1	2	4.4	O=C(O)C#Cc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.ejmech.2018.08.075
	CHEMBL4288438	173799	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	328	4	1	2	4.4	O=C(O)C#Cc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.ejmech.2018.08.075
	137637576	162842	0	None	-63	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	162842	0	None	-63	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	23083193	65611	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.4	Cc1ccccc1Oc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688461	65611	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.4	Cc1ccccc1Oc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	118645756	188241	7	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR40 assessed as increase in intracellular calcium levelAgonist activity at mouse GPR40 assessed as increase in intracellular calcium level	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764485	188241	7	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR40 assessed as increase in intracellular calcium levelAgonist activity at mouse GPR40 assessed as increase in intracellular calcium level	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	90644286	118730	0	None	-10	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288344	118730	0	None	-10	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	71562639	93296	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	294	5	1	2	3.3	COCc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315252	93296	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	294	5	1	2	3.3	COCc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	66562392	97147	0	None	83	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
	CHEMBL2386365	97147	0	None	83	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
	145947987	174513	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	351	7	1	4	4.6	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4228673	174513	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	351	7	1	4	4.6	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4302779	174513	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	351	7	1	4	4.6	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmc.2017.12.030
	23111781	80825	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2016.03.014
	CHEMBL2022247	80825	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2016.03.014
	24857286	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2014.11.016
	6484	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2014.11.016
	CHEMBL1829174	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2014.11.016
	DB12491	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2014.11.016
	147747458	177360	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	437	10	2	4	6.0	CCCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4450552	177360	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	437	10	2	4	6.0	CCCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	71615668	96777	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1ccc(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(C)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381313	96777	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1ccc(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(C)c1	10.1016/j.bmcl.2013.03.060
	127045657	146665	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	403	7	1	4	5.3	Cc1noc(C)c1-c1cc(Cl)cc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3799341	146665	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	403	7	1	4	5.3	Cc1noc(C)c1-c1cc(Cl)cc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	57787398	150529	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assay	ChEMBL	448	9	2	7	3.1	Cc1cc(OCCO)ccc1-c1cccc(COc2ccc(Cn3oc(=O)[nH]c3=O)cc2)c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3900797	150529	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based FLIPR assay	ChEMBL	448	9	2	7	3.1	Cc1cc(OCCO)ccc1-c1cccc(COc2ccc(Cn3oc(=O)[nH]c3=O)cc2)c1	10.1016/j.bmcl.2016.10.074
	67972848	173421	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	356	4	1	2	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(C#CC(=O)O)cc2)c1	10.1016/j.ejmech.2018.08.075
	CHEMBL4281238	173421	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	356	4	1	2	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(C#CC(=O)O)cc2)c1	10.1016/j.ejmech.2018.08.075
	122185432	129441	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	350	8	1	3	4.4	CCOC(c1ccc(OCc2ccccc2C)cc1)C(F)(F)C(=O)O	10.1016/j.bmc.2015.07.028
	CHEMBL3604030	129441	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	350	8	1	3	4.4	CCOC(c1ccc(OCc2ccccc2C)cc1)C(F)(F)C(=O)O	10.1016/j.bmc.2015.07.028
	137660172	165892	0	None	1	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	CHEMBL4097652	165892	0	None	1	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	71460255	87571	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1021/ml300133f
	CHEMBL2152069	87571	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1021/ml300133f
	118638010	174344	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165008	174344	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300503	174344	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	90372613	174523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4166625	174523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302869	174523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	23136401	165914	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	165914	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	145981599	173234	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	370	7	1	4	4.4	CC(C)(C)c1cccc(OCCOc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.ejmech.2018.09.071
	CHEMBL4277858	173234	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	370	7	1	4	4.4	CC(C)(C)c1cccc(OCCOc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.ejmech.2018.09.071
	137629794	167961	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	545	12	1	7	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ncccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4093571	167961	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	545	12	1	7	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ncccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4117644	167961	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	545	12	1	7	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ncccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	145993490	174129	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	429	7	1	7	3.3	Cn1nncc1C(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4294530	174129	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	429	7	1	7	3.3	Cn1nncc1C(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	118144973	182063	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4572891	182063	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	127031569	145962	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787580	145962	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	118719474	122314	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	512	12	1	6	5.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OC(C)C(=O)O)cc2)c1	10.1016/j.bmc.2014.11.016
	CHEMBL3353262	122314	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	512	12	1	6	5.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OC(C)C(=O)O)cc2)c1	10.1016/j.bmc.2014.11.016
	54757623	72110	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	257	3	1	3	2.6	O=C(O)CCc1ccc(C#Cc2cncs2)cc1	10.1021/jm2005699
	CHEMBL1829154	72110	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	257	3	1	3	2.6	O=C(O)CCc1ccc(C#Cc2cncs2)cc1	10.1021/jm2005699
	57414404	82391	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
	CHEMBL2047154	82391	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
	131986130	171204	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	572	11	1	7	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4213597	171204	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	572	11	1	7	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	145953365	169240	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4166892	169240	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	23111666	80831	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4csc5ccccc45)c3)ccc21	10.1021/jm2012968
	CHEMBL2022253	80831	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4csc5ccccc45)c3)ccc21	10.1021/jm2012968
	58230552	188998	0	None	-4	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	CHEMBL4783190	188998	0	None	-4	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	131986136	170404	0	None	-3	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	512	8	1	6	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4203795	170404	0	None	-3	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	512	8	1	6	6.5	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	24857286	8405	72	None	-28	3	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	6484	8405	72	None	-28	3	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	CHEMBL1829174	8405	72	None	-28	3	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	DB12491	8405	72	None	-28	3	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.8b00444
	24857286	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.08.075
	6484	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.08.075
	CHEMBL1829174	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.08.075
	DB12491	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.08.075
	71613313	96771	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	402	4	1	4	5.1	Cc1ccccc1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381307	96771	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	402	4	1	4	5.1	Cc1ccccc1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	145988414	171993	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	413	6	1	5	5.1	Cc1noc(C)c1-c1ccc(Cl)c(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4229006	171993	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	413	6	1	5	5.1	Cc1noc(C)c1-c1ccc(Cl)c(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	24825485	94803	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	343	6	2	2	5.2	O=C(O)C1CC1c1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234450	94803	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	343	6	2	2	5.2	O=C(O)C1CC1c1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.12.084
	71562769	93300	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	3	1	2	3.3	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315256	93300	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	3	1	2	3.3	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	44409665	82366	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	388	9	2	3	5.5	CC(C)NC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL204671	82366	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	388	9	2	3	5.5	CC(C)NC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	168271642	197092	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	486	11	1	4	6.5	Cc1ccc(OCCc2ccccc2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5176157	197092	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	486	11	1	4	6.5	Cc1ccc(OCCc2ccccc2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	168288738	198187	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	446	9	1	4	6.1	CCOc1ccc2cc(-c3cccc(COc4ccc(OCC(=O)O)c(F)c4)c3)ccc2c1	10.1016/j.bmc.2022.116615
	CHEMBL5192621	198187	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	446	9	1	4	6.1	CCOc1ccc2cc(-c3cccc(COc4ccc(OCC(=O)O)c(F)c4)c3)ccc2c1	10.1016/j.bmc.2022.116615
	137653172	165312	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	480	6	1	6	4.5	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cccc(F)n4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4091456	165312	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	480	6	1	6	4.5	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cccc(F)n4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	145955263	169320	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	414	6	2	3	6.1	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(O)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	CHEMBL4168048	169320	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	414	6	2	3	6.1	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(O)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	57706778	87572	29	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL2152070	87572	29	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	57706778	87572	29	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL2152070	87572	29	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2019.04.050
	137640728	163811	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	406	8	1	3	6.6	Cc1cccc(C)c1-c1cccc(COc2ccc(C(CC(=O)O)C3CC3)s2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4073587	163811	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	406	8	1	3	6.6	Cc1cccc(C)c1-c1cccc(COc2ccc(C(CC(=O)O)C3CC3)s2)c1	10.1021/acs.jmedchem.6b01357
	54581633	68935	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	331	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2nccc3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777869	68935	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	331	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2nccc3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	155530636	178314	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	438	11	2	6	4.3	CO/N=C(\COc1ccc(CNc2ccc(OCC(=O)O)c(F)c2)cc1)c1ccccc1	10.1016/j.ejmech.2019.06.087
	CHEMBL4464317	178314	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	438	11	2	6	4.3	CO/N=C(\COc1ccc(CNc2ccc(OCC(=O)O)c(F)c2)cc1)c1ccccc1	10.1016/j.ejmech.2019.06.087
	24825480	94764	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1cccc(NCc2cccc(Oc3ccccc3)c2)c1	10.1016/j.bmcl.2006.12.084
	CHEMBL234267	94764	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1cccc(NCc2cccc(Oc3ccccc3)c2)c1	10.1016/j.bmcl.2006.12.084
	145979123	173245	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	370	5	1	2	5.5	CC(C)c1ccccc1-c1cccc(COc2ccc(C#CC(=O)O)cc2)c1	10.1016/j.ejmech.2018.08.075
	CHEMBL4278085	173245	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	370	5	1	2	5.5	CC(C)c1ccccc1-c1cccc(COc2ccc(C#CC(=O)O)cc2)c1	10.1016/j.ejmech.2018.08.075
	24825483	83655	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	333	7	2	3	4.7	O=C(O)Cc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL206972	83655	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	333	7	2	3	4.7	O=C(O)Cc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	24825495	94808	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	289	6	2	2	4.0	O=C(O)CCc1ccc(NCc2ccccc2Cl)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234469	94808	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	289	6	2	2	4.0	O=C(O)CCc1ccc(NCc2ccccc2Cl)cc1	10.1016/j.bmcl.2006.12.084
	24825496	94809	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	269	6	2	2	3.6	Cc1ccc(CNc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234470	94809	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	269	6	2	2	3.6	Cc1ccc(CNc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2006.12.084
	137637576	162842	0	None	-63	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	162842	0	None	-63	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	23136401	165914	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	165914	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	168285919	198453	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	534	9	2	5	6.7	Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@@H]2Oc1ccc2c(c1)OC[C@@H]2CC(=O)O	10.1016/j.bmcl.2021.127969
	CHEMBL5196447	198453	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	534	9	2	5	6.7	Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@@H]2Oc1ccc2c(c1)OC[C@@H]2CC(=O)O	10.1016/j.bmcl.2021.127969
	134538585	170414	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	518	9	3	5	6.3	Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	CHEMBL4203974	170414	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	518	9	3	5	6.3	Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	145976639	170594	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	523	6	2	5	6.2	Cc1cc(-c2cccc(=O)n2C)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	CHEMBL4206195	170594	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	523	6	2	5	6.2	Cc1cc(-c2cccc(=O)n2C)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	131986295	170321	0	None	2	2	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4202907	170321	0	None	2	2	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986030	171593	0	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	566	11	2	7	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218596	171593	0	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	566	11	2	7	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	134465785	182890	0	None	15	2	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4591657	182890	0	None	15	2	Rat	8.4	pEC50	=	8.4	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	162673875	189765	0	None	-13	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4793371	189765	0	None	-13	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
	68194449	189593	0	None	-4	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4790921	189593	0	None	-4	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	90372625	174500	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159022	174500	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302640	174500	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	44409703	147979	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	431	6	2	4	5.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(N)=O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL382831	147979	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	431	6	2	4	5.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(N)=O)cc1	10.1016/j.bmcl.2006.01.007
	57413373	82602	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	466	12	1	4	6.1	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2048618	82602	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	466	12	1	4	6.1	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	118645526	189759	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	5.8	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2N2CC3(CCC3)C2)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4793322	189759	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	517	10	1	6	5.8	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2N2CC3(CCC3)C2)c1	10.1016/j.bmcl.2018.01.013
	118144973	182063	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4572891	182063	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	67087100	189377	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4788206	189377	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	164616320	191824	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	333	4	2	1	5.2	O=C(O)CCc1ccc2[nH]c(-c3cccc(Cl)c3Cl)cc2c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4855306	191824	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	333	4	2	1	5.2	O=C(O)CCc1ccc2[nH]c(-c3cccc(Cl)c3Cl)cc2c1	10.1021/acs.jmedchem.1c00031
	147146439	178064	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	365	7	2	3	4.9	Cc1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4460582	178064	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	365	7	2	3	4.9	Cc1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	44409722	147794	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL382381	147794	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	432	6	2	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	162674654	190234	0	None	-9	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4798993	190234	0	None	-9	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
	134465730	179582	0	None	1	2	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4513748	179582	0	None	1	2	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	440	9	1	3	6.4	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@H](C)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	51349992	65608	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.4	Cc1ccc(Oc2cccc(COc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/jm101405t
	CHEMBL1688459	65608	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.4	Cc1ccc(Oc2cccc(COc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/jm101405t
	146840871	176304	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	458	8	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(OC)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4434996	176304	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	458	8	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(OC)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	23083189	82594	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	374	7	1	2	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm2016123
	CHEMBL2048610	82594	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	374	7	1	2	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm2016123
	71562638	93295	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	294	5	1	2	3.3	COCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315251	93295	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	294	5	1	2	3.3	COCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	54669771	72126	8	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	319	3	1	2	3.8	O=C(O)CCc1ccc(C#Cc2cc(Cl)nc(Cl)c2)cc1	10.1021/jm2005699
	CHEMBL1829170	72126	8	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	319	3	1	2	3.8	O=C(O)CCc1ccc(C#Cc2cc(Cl)nc(Cl)c2)cc1	10.1021/jm2005699
	168285917	198452	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	382	8	1	4	4.5	COc1ccc(-c2cccc(OCc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.ejmech.2021.114061
	CHEMBL5196445	198452	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	382	8	1	4	4.5	COc1ccc(-c2cccc(OCc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.ejmech.2021.114061
	155548030	180458	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	462	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4cccc(Cl)c4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4535007	180458	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	462	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4cccc(Cl)c4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	75511297	129288	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	344	7	1	6	4.0	CC(Oc1ccc(CCC(=O)O)cc1)c1nc(-c2cccs2)no1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601056	129288	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	344	7	1	6	4.0	CC(Oc1ccc(CCC(=O)O)cc1)c1nc(-c2cccs2)no1	10.1016/j.bmcl.2015.06.018
	71461901	87436	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	400	8	1	3	5.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(-c3cccc(OC)c3)cc2)cc1	10.1021/ml300133f
	CHEMBL2151289	87436	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	400	8	1	3	5.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(-c3cccc(OC)c3)cc2)cc1	10.1021/ml300133f
	145946416	174320	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	519	9	1	4	6.5	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CCN(CCc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4248812	174320	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	519	9	1	4	6.5	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CCN(CCc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4300233	174320	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	519	9	1	4	6.5	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CCN(CCc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	118642379	148897	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883354	148897	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	137636033	162955	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	410	9	1	4	6.2	CCO[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4063956	162955	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	410	9	1	4	6.2	CCO[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	46232309	207866	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	351	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2)O1	10.1016/j.bmcl.2009.10.052
	CHEMBL602868	207866	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	351	4	1	4	4.0	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2)O1	10.1016/j.bmcl.2009.10.052
	141747238	173223	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	344	5	1	3	4.5	O=C(O)C#Cc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1016/j.ejmech.2018.08.075
	CHEMBL4277653	173223	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	344	5	1	3	4.5	O=C(O)C#Cc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1016/j.ejmech.2018.08.075
	118637972	169096	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	428	7	1	3	6.4	COc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4164618	169096	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	428	7	1	3	6.4	COc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	118638001	148898	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883355	148898	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	57521918	83051	0	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058531	83051	0	None	1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	54757513	72100	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccncc2)cc1	10.1021/jm2005699
	CHEMBL1829145	72100	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccncc2)cc1	10.1021/jm2005699
	54582630	68932	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777866	68932	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	46854655	7183	47	None	-8	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml400501x
	6485	7183	47	None	-8	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml400501x
	CHEMBL1829173	7183	47	None	-8	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml400501x
	146695343	178632	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	423	10	2	4	5.7	CCCOc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4468987	178632	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	423	10	2	4	5.7	CCCOc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	145754982	169241	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	510	10	1	6	4.9	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3C(=O)O)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4166922	169241	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	510	10	1	6	4.9	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3C(=O)O)c1	10.1016/j.ejmech.2017.07.001
	24857286	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
	6484	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
	CHEMBL1829174	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
	DB12491	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
	155515835	176777	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	439	11	2	5	4.9	COCCOc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4442354	176777	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	439	11	2	5	4.9	COCCOc1ccc(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	132578494	161291	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	531	10	1	4	6.4	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3941821	161291	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	531	10	1	4	6.4	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990702	161291	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	531	10	1	4	6.4	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccc(F)cc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	137643956	165052	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	540	12	1	6	6.0	CC#C[C@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4088797	165052	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	540	12	1	6	6.0	CC#C[C@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	162659927	188161	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	500	12	1	3	8.3	COc1ccc(CCCC(C)(C)C)c(-c2ccc(COc3cccc(C(CC(=O)O)C4CC4)c3)cc2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4763356	188161	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	500	12	1	3	8.3	COc1ccc(CCCC(C)(C)C)c(-c2ccc(COc3cccc(C(CC(=O)O)C4CC4)c3)cc2)c1	10.1021/acs.jmedchem.0c00843
	127027730	144493	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	443	7	1	6	4.6	O=C1NC(=O)C(Cc2ccc(OCc3nc4ccccc4n3Cc3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3758919	144493	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	443	7	1	6	4.6	O=C1NC(=O)C(Cc2ccc(OCc3nc4ccccc4n3Cc3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	145965797	171164	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	501	9	2	7	4.9	O=C(O)CCc1ccc(NC(=O)c2nnc(CC(c3ccccc3)c3ccc4c(c3)OCO4)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4213089	171164	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	501	9	2	7	4.9	O=C(O)CCc1ccc(NC(=O)c2nnc(CC(c3ccccc3)c3ccc4c(c3)OCO4)s2)cc1	10.1016/j.ejmech.2017.09.019
	90372365	148920	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	8	1	4	7.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2OC(F)(F)F)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883504	148920	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	8	1	4	7.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2OC(F)(F)F)c1	10.1021/acsmedchemlett.6b00443
	58319139	93318	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	278	3	1	1	3.7	Cc1cccc(C)c1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315542	93318	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	278	3	1	1	3.7	Cc1cccc(C)c1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	127030715	145776	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	214	3	1	1	2.6	C=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785544	145776	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	214	3	1	1	2.6	C=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	24825484	94766	0	None	208	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/ml100106c
	CHEMBL234269	94766	0	None	208	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/ml100106c
	145959722	168969	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	544	8	1	5	6.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(C(C)(C)C)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4162588	168969	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	544	8	1	5	6.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(C(C)(C)C)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	134135852	151159	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	502	9	1	8	3.6	CCOc1ccc(F)c(N2CC[C@@H](Oc3cnc(N4CC(OC)[C@@H](C)[C@@H]4CC(=O)O)cn3)[C@H](C)C2)c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3905856	151159	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	502	9	1	8	3.6	CCOc1ccc(F)c(N2CC[C@@H](Oc3cnc(N4CC(OC)[C@@H](C)[C@@H]4CC(=O)O)cn3)[C@H](C)C2)c1	10.1016/j.bmcl.2016.10.074
	54586484	68928	0	None	-2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777862	68928	0	None	-2	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	145950402	169702	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	467	8	2	3	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)NC3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4174136	169702	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	467	8	2	3	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)NC3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	145953365	169240	0	None	-1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4166892	169240	0	None	-1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR40Agonist activity at mouse GPR40	ChEMBL	467	8	2	3	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N[C@H]3CCCc4ccccc43)cc2)cc1	10.1016/j.ejmech.2018.04.023
	56680363	72128	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	331	2	1	2	4.0	O=C(O)C1CC1c1ccc(C#Cc2cc(Cl)nc(Cl)c2)cc1	10.1021/jm2005699
	CHEMBL1829172	72128	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	331	2	1	2	4.0	O=C(O)C1CC1c1ccc(C#Cc2cc(Cl)nc(Cl)c2)cc1	10.1021/jm2005699
	57706642	87446	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	490	9	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151299	87446	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	490	9	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCC4)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	90644291	118735	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288349	118735	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	362	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nn2)c1	10.1016/j.bmcl.2014.04.065
	168287667	198440	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	466	12	1	5	5.8	CCOc1ccc(/C=C/c2cc(OCC)cc(OCc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.ejmech.2021.114061
	CHEMBL5196235	198440	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	466	12	1	5	5.8	CCOc1ccc(/C=C/c2cc(OCC)cc(OCc3ccc(OCC(=O)O)c(F)c3)c2)cc1	10.1016/j.ejmech.2021.114061
	134142866	152420	0	None	-9	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	152420	0	None	-9	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	71562641	93298	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	400	9	1	4	3.3	CS(=O)(=O)CCCCOc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315254	93298	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	400	9	1	4	3.3	CS(=O)(=O)CCCCOc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	145964802	171058	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	415	7	1	6	3.7	Cc1ccc(-c2c(C)noc2C)cc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4211807	171058	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	415	7	1	6	3.7	Cc1ccc(-c2c(C)noc2C)cc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	66562391	145767	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	262	4	2	2	2.1	C/C(C#Cc1ccc(CCC(=O)O)c(F)c1)=C/CO	10.1021/acs.jmedchem.5b01962
	CHEMBL3785413	145767	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	262	4	2	2	2.1	C/C(C#Cc1ccc(CCC(=O)O)c(F)c1)=C/CO	10.1021/acs.jmedchem.5b01962
	145980608	173423	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	404	9	1	4	5.2	O=C(O)CC1COc2cc(OCCCOc3ccc(-c4ccccc4)cc3)ccc21	10.1016/j.ejmech.2018.09.071
	CHEMBL4281316	173423	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	404	9	1	4	5.2	O=C(O)CC1COc2cc(OCCCOc3ccc(-c4ccccc4)cc3)ccc21	10.1016/j.ejmech.2018.09.071
	54757621	72097	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	300	3	1	3	2.9	Cc1cnc(Cl)nc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm2005699
	CHEMBL1829142	72097	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	300	3	1	3	2.9	Cc1cnc(Cl)nc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm2005699
	46231656	207894	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1ccnc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	CHEMBL603066	207894	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1ccnc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	134130696	148915	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	CHEMBL3883449	148915	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	118638001	148898	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883355	148898	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)nc2)c1	10.1021/acsmedchemlett.6b00443
	122193975	130757	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	502	12	1	6	4.7	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3629049	130757	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	502	12	1	6	4.7	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	25150120	180783	1	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL454257	180783	1	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	264	3	1	1	3.4	Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	54757831	72127	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	333	3	1	2	4.1	Cc1c(C#Cc2ccc(CCC(=O)O)cc2)cc(Cl)nc1Cl	10.1021/jm2005699
	CHEMBL1829171	72127	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	333	3	1	2	4.1	Cc1c(C#Cc2ccc(CCC(=O)O)cc2)cc(Cl)nc1Cl	10.1021/jm2005699
	58218673	164304	0	None	-5	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	413	5	1	3	5.7	Cc1c(Cl)cccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4079930	164304	0	None	-5	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	413	5	1	3	5.7	Cc1c(Cl)cccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	853224	101350	11	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Activity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	CHEMBL251963	101350	11	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Activity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	127050771	147007	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	397	8	2	6	3.7	Cc1ccc(NC(=O)c2nnc(COc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805246	147007	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	397	8	2	6	3.7	Cc1ccc(NC(=O)c2nnc(COc3ccc(CCC(=O)O)cc3)s2)cc1	10.1016/j.bmc.2016.04.065
	145979252	173427	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	442	7	1	4	5.3	O=C(O)CC(c1ccc(F)cc1)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4281376	173427	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	442	7	1	4	5.3	O=C(O)CC(c1ccc(F)cc1)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	145962164	168256	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	367	6	1	6	3.0	O=C1NC(=O)C(Cc2ccc(OCCn3cnc4ccccc43)cc2)S1	10.1016/j.bmcl.2018.03.051
	CHEMBL4127761	168256	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	367	6	1	6	3.0	O=C1NC(=O)C(Cc2ccc(OCCn3cnc4ccccc43)cc2)S1	10.1016/j.bmcl.2018.03.051
	53248846	68927	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777861	68927	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	46941175	68586	26	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albumin	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1773261	68586	26	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albumin	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	162659599	187977	0	None	-4	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4761101	187977	0	None	-4	2	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	90151205	164065	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	493	6	1	5	5.4	Cc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4076882	164065	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	493	6	1	5	5.4	Cc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	162666840	189233	0	None	-3	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	CHEMBL4786299	189233	0	None	-3	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
	137638184	163535	0	None	-1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	6	1	3	4.6	O=C(O)C[C@@H]1CCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4070619	163535	0	None	-1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	365	6	1	3	4.6	O=C(O)C[C@@H]1CCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	134129938	149218	0	None	-263	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890089	149218	0	None	-263	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	58319127	93327	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	266	3	2	2	2.8	O=C(O)CCc1ccc(C#Cc2cccc(O)c2)cc1	10.1021/jm301470a
	CHEMBL2315551	93327	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	266	3	2	2	2.8	O=C(O)CCc1ccc(C#Cc2cccc(O)c2)cc1	10.1021/jm301470a
	54580132	68578	0	None	3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/ml100106c
	CHEMBL1773253	68578	0	None	3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/ml100106c
	57521913	83045	0	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058526	83045	0	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	142738545	169055	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	279	4	2	1	4.2	Cc1ccccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acsmedchemlett.7b00460
	CHEMBL4164008	169055	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	279	4	2	1	4.2	Cc1ccccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acsmedchemlett.7b00460
	46231713	207815	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)nc1	10.1016/j.bmcl.2009.10.052
	CHEMBL602457	207815	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	314	4	1	5	3.1	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)nc1	10.1016/j.bmcl.2009.10.052
	51349993	65610	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.4	Cc1cccc(Oc2cccc(COc3ccc(CCC(=O)O)cc3)c2)c1	10.1021/jm101405t
	CHEMBL1688460	65610	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.4	Cc1cccc(Oc2cccc(COc3ccc(CCC(=O)O)cc3)c2)c1	10.1021/jm101405t
	24857286	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	6484	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	CHEMBL1829174	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	DB12491	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.09.071
	24857286	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2021.114061
	6484	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2021.114061
	CHEMBL1829174	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2021.114061
	DB12491	8405	72	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2021.114061
	155550483	181082	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	501	12	2	6	4.7	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4550165	181082	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	501	12	2	6	4.7	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	127046960	146769	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2017.12.030
	CHEMBL3799946	146769	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2017.12.030
	CHEMBL4227915	146769	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	369	7	1	4	4.7	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2017.12.030
	25150014	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm2005699
	3952	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm2005699
	CHEMBL449588	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm2005699
	25150014	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	3952	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	CHEMBL449588	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	60195125	10660	8	None	4	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	10660	8	None	4	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	10660	8	None	4	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation by dynamic mass redistribution assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as receptor activation by dynamic mass redistribution assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	145963855	170978	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	476	9	1	3	7.4	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4210827	170978	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	476	9	1	3	7.4	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	168285924	198454	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	392	7	1	4	5.3	O=C(O)COc1ccc(OCc2cccc(-c3ccc4ccoc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	CHEMBL5196452	198454	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	392	7	1	4	5.3	O=C(O)COc1ccc(OCc2cccc(-c3ccc4ccoc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	137639817	163583	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	504	10	1	5	6.6	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCC4(C)COC4)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4071066	163583	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	504	10	1	5	6.6	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCC4(C)COC4)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	137653896	165324	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	326	6	1	4	3.4	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cn1	10.1021/acs.jmedchem.6b01559
	CHEMBL4091552	165324	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	326	6	1	4	3.4	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cn1	10.1021/acs.jmedchem.6b01559
	90151652	165453	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	507	7	1	5	5.7	CCc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4092937	165453	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	507	7	1	5	5.7	CCc1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	90151514	166440	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	495	6	1	5	5.6	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccccc4Cl)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4103854	166440	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	495	6	1	5	5.6	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccccc4Cl)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	58218630	166434	0	None	-13	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4103729	166434	0	None	-13	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	137637243	162668	0	None	-4	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4060517	162668	0	None	-4	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	134143394	161259	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	545	11	1	7	5.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3nc(C5CC5)no3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3917858	161259	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	545	11	1	7	5.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3nc(C5CC5)no3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990389	161259	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	545	11	1	7	5.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3nc(C5CC5)no3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	53248846	68927	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777861	68927	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	54580132	68578	0	None	3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	CHEMBL1773253	68578	0	None	3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	145966167	171002	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	407	7	1	5	3.7	N#Cc1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4211064	171002	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	407	7	1	5	3.7	N#Cc1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	561372	65601	65	None	20	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1688452	65601	65	None	20	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/ml100106c
	75511317	129289	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	372	7	1	5	4.3	Cc1cccc(-c2noc(COc3ccc(CCC(=O)O)cc3Cl)n2)c1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601057	129289	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	372	7	1	5	4.3	Cc1cccc(-c2noc(COc3ccc(CCC(=O)O)cc3Cl)n2)c1	10.1016/j.bmcl.2015.06.018
	145955263	169320	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	414	6	2	3	6.1	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(O)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	CHEMBL4168048	169320	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	414	6	2	3	6.1	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(O)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	145990715	173776	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4288001	173776	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	25150014	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm301470a
	3952	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm301470a
	CHEMBL449588	10657	55	None	44	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm301470a
	162668241	189285	0	None	-4	2	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4787007	189285	0	None	-4	2	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	71612898	96759	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1ccc(F)c([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381295	96759	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1ccc(F)c([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	71562771	93306	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	305	5	1	3	3.0	N#CCOc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315530	93306	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	305	5	1	3	3.0	N#CCOc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	145974495	171504	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	396	7	1	4	4.1	Cc1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4217477	171504	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	396	7	1	4	4.1	Cc1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	127032539	145588	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	377	6	1	4	4.6	Cc1ccc(C)n1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2016.03.014
	CHEMBL3781077	145588	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	377	6	1	4	4.6	Cc1ccc(C)n1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2016.03.014
	155522452	177493	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	442	7	1	4	5.4	O=C(O)CCc1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)cc4)cc3O2)cc1F	10.1016/j.bmcl.2019.01.014
	CHEMBL4452044	177493	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	442	7	1	4	5.4	O=C(O)CCc1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)cc4)cc3O2)cc1F	10.1016/j.bmcl.2019.01.014
	137657002	166581	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	3	3.7	Cc1ccccc1C(=O)c1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4105565	166581	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	3	3.7	Cc1ccccc1C(=O)c1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	90372625	174500	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159022	174500	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302640	174500	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	5280933	184999	64	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	278	13	1	1	5.7	CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O	10.1016/j.ejmech.2015.12.049
	CHEMBL464982	184999	64	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	278	13	1	1	5.7	CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O	10.1016/j.ejmech.2015.12.049
	71562768	93299	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	3	1	2	3.3	Cc1ccc(C#N)c(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315255	93299	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	289	3	1	2	3.3	Cc1ccc(C#N)c(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	127050769	147046	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	413	9	2	7	3.4	COc1cccc(NC(=O)c2nnc(COc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.bmc.2016.04.065
	CHEMBL3805670	147046	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	413	9	2	7	3.4	COc1cccc(NC(=O)c2nnc(COc3ccc(CCC(=O)O)cc3)s2)c1	10.1016/j.bmc.2016.04.065
	23083190	65612	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	376	8	1	3	5.7	Cc1cccc(C)c1Oc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688462	65612	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	376	8	1	3	5.7	Cc1cccc(C)c1Oc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	156013404	184238	3	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	440	8	1	5	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC)cc4)cn3c2)cc1	10.1016/j.bmcl.2021.127969
	CHEMBL4638956	184238	3	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	440	8	1	5	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC)cc4)cn3c2)cc1	10.1016/j.bmcl.2021.127969
	131986378	171360	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	552	11	1	7	6.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4215544	171360	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	552	11	1	7	6.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	145950347	169617	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4172828	169617	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	54586486	68936	0	None	-1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	320	5	1	2	4.3	CC#CC(CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777870	68936	0	None	-1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	320	5	1	2	4.3	CC#CC(CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmcl.2011.03.114
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assayAgonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm8010178
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assayAgonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm8010178
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assayAgonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm8010178
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm2005699
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm2005699
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm2005699
	127031003	145922	0	None	371	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787072	145922	0	None	371	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	3681700	207093	15	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	299	4	1	4	3.4	O=C1NC(=O)C(Cc2cccc(Oc3ccccc3)c2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL597424	207093	15	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	299	4	1	4	3.4	O=C1NC(=O)C(Cc2cccc(Oc3ccccc3)c2)S1	10.1016/j.bmcl.2009.10.052
	9995943	207316	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	317	4	1	4	3.5	O=C1NC(=O)C(Cc2ccc(Oc3ccc(F)cc3)cc2)S1	10.1016/j.bmcl.2011.03.114
	CHEMBL598935	207316	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	317	4	1	4	3.5	O=C1NC(=O)C(Cc2ccc(Oc3ccc(F)cc3)cc2)S1	10.1016/j.bmcl.2011.03.114
	86803183	129235	1	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	357	7	1	4	4.6	O=C(O)CCc1ccc(OCc2ncc(-c3cccc(Cl)c3)o2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600999	129235	1	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	357	7	1	4	4.6	O=C(O)CCc1ccc(OCc2ncc(-c3cccc(Cl)c3)o2)cc1	10.1016/j.bmcl.2015.06.018
	54757733	72117	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	343	5	1	3	4.3	O=C(O)CCc1ccc(C#Cc2ccnc(Oc3ccccc3)c2)cc1	10.1021/jm2005699
	CHEMBL1829161	72117	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	343	5	1	3	4.3	O=C(O)CCc1ccc(C#Cc2ccnc(Oc3ccccc3)c2)cc1	10.1021/jm2005699
	54582150	68584	0	None	22	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1773259	68584	0	None	22	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	11271473	81247	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022584	81247	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2027975	81247	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	54586484	68928	0	None	2	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777862	68928	0	None	2	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	118645671	187708	0	None	-5	2	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	476	10	1	5	6.3	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C=C(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4758060	187708	0	None	-5	2	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	476	10	1	5	6.3	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C=C(C)C)c1	10.1016/j.bmcl.2018.01.013
	127034370	145619	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	399	6	1	5	4.8	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	CHEMBL3781477	145619	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	399	6	1	5	4.8	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	44409664	84065	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	360	8	2	3	4.8	CNC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL208175	84065	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	360	8	2	3	4.8	CNC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	71460255	87571	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1021/ml300133f
	CHEMBL2152069	87571	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1021/ml300133f
	168276826	196903	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	396	9	1	4	4.9	CCOc1cccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5173326	196903	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	396	9	1	4	4.9	CCOc1cccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	168278602	197765	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	472	10	1	4	6.5	O=C(O)COc1ccc(OCc2cccc(-c3ccc4cc(OCC5CC5)ccc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	CHEMBL5186275	197765	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	472	10	1	4	6.5	O=C(O)COc1ccc(OCc2cccc(-c3ccc4cc(OCC5CC5)ccc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	9995943	207316	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	317	4	1	4	3.5	O=C1NC(=O)C(Cc2ccc(Oc3ccc(F)cc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL598935	207316	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	317	4	1	4	3.5	O=C1NC(=O)C(Cc2ccc(Oc3ccc(F)cc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	90151529	164547	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	497	6	1	5	5.2	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(F)ccc4F)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4082717	164547	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	497	6	1	5	5.2	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(F)ccc4F)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	1052	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2019.01.014
	3323	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2019.01.014
	5280450	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2019.01.014
	CHEMBL267476	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2019.01.014
	DB14104	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2019.01.014
	1052	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmc.2018.10.019
	3323	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmc.2018.10.019
	5280450	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmc.2018.10.019
	CHEMBL267476	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmc.2018.10.019
	DB14104	9101	85	None	-5	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmc.2018.10.019
	127030344	145923	0	None	69	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787110	145923	0	None	69	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
	51350270	65613	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/ml100106c
	CHEMBL1688463	65613	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)cc1	10.1021/ml100106c
	11327107	80826	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/ml1000855
	CHEMBL2022248	80826	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/ml1000855
	122185444	129466	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	354	7	1	3	5.3	CCOC(CC(=O)O)c1ccc(Oc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604054	129466	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	354	7	1	3	5.3	CCOC(CC(=O)O)c1ccc(Oc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	58172989	118746	0	None	3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	389	6	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2cc3c(cn2)C(CC(=O)O)OC3)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288360	118746	0	None	3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	389	6	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2cc3c(cn2)C(CC(=O)O)OC3)c1	10.1016/j.bmcl.2014.04.065
	122193735	130746	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	410	8	1	4	5.2	COc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3628755	130746	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	410	8	1	4	5.2	COc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	168293256	198918	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	464	10	1	4	6.4	Cc1ccc(OCC2CCCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5203672	198918	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	464	10	1	4	6.4	Cc1ccc(OCC2CCCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	137631853	163091	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1ccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4065518	163091	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1ccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)cc1	10.1021/acs.jmedchem.6b01559
	132606864	164525	0	None	2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4082395	164525	0	None	2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	23111708	80824	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	386	6	1	3	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc3c(CC(=O)O)coc3c2)c1	10.1021/jm2012968
	CHEMBL2022246	80824	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	386	6	1	3	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc3c(CC(=O)O)coc3c2)c1	10.1021/jm2012968
	118145020	177848	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cnc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4457184	177848	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cnc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	127046666	146783	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1cncc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3800040	146783	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1cncc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	45107311	125910	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	360	7	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(Cl)cccc32)cc1	10.1021/ml500391n
	CHEMBL3427711	125910	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	360	7	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(Cl)cccc32)cc1	10.1021/ml500391n
	45107311	125910	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	360	7	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(Cl)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427711	125910	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	360	7	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(Cl)cccc32)cc1	10.1016/j.bmc.2015.07.028
	68194449	189593	0	None	-4	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4790921	189593	0	None	-4	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	90356885	174314	0	None	16	2	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4168422	174314	0	None	16	2	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300181	174314	0	None	16	2	Rat	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	462	7	1	5	5.6	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	90372616	149011	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	45107476	125772	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	4.8	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1021/ml500391n
	CHEMBL3425533	125772	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	4.8	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1021/ml500391n
	45107476	125772	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	4.8	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3425533	125772	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	4.8	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmc.2015.07.028
	73051869	174218	4	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	521	10	1	6	4.7	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2cc3c(cn2)[C@@H]2[C@@H](C(=O)O)[C@@H]2C3)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4297471	174218	4	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	521	10	1	6	4.7	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2cc3c(cn2)[C@@H]2[C@@H](C(=O)O)[C@@H]2C3)c1	10.1021/acs.jmedchem.1c00031
	51350138	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm101405t
	CHEMBL1688473	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm101405t
	51350138	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml1000855
	CHEMBL1688473	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml1000855
	51350138	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPRAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPR	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL1688473	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPRAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPR	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	6483	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
	66553168	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
	CHEMBL2386353	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
	90372613	174523	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4166625	174523	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302869	174523	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.1c00031
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.1c00031
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.1c00031
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acsmedchemlett.7b00460
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acsmedchemlett.7b00460
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acsmedchemlett.7b00460
	137653903	165346	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	410	9	1	4	6.2	CCO[C@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4091723	165346	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	410	9	1	4	6.2	CCO[C@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	145952673	169215	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	443	7	1	4	4.6	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCc4ccccc4C3)o2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4166397	169215	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	443	7	1	4	4.6	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCc4ccccc4C3)o2)cc1	10.1016/j.ejmech.2018.04.023
	145990715	173776	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4288001	173776	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	24825479	154045	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	359	7	2	3	5.3	O=C(O)C1CC1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL392869	154045	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	359	7	2	3	5.3	O=C(O)C1CC1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.12.084
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	51350272	65615	0	None	107	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1688465	65615	0	None	107	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	86817649	129238	2	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	372	7	1	5	4.5	CC(Oc1ccc(CCC(=O)O)cc1)c1nc(-c2ccc(Cl)cc2)no1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601002	129238	2	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	372	7	1	5	4.5	CC(Oc1ccc(CCC(=O)O)cc1)c1nc(-c2ccc(Cl)cc2)no1	10.1016/j.bmcl.2015.06.018
	137636358	162665	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	517	8	1	4	6.8	COc1ccc(F)c(Cc2cccc(Oc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4060499	162665	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	517	8	1	4	6.8	COc1ccc(F)c(Cc2cccc(Oc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	90151428	164830	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	475	6	1	5	5.3	Cc1ccccc1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	CHEMBL4085928	164830	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	475	6	1	5	5.3	Cc1ccccc1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	58218709	165197	0	None	-4	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c1C	10.1021/acs.jmedchem.6b01559
	CHEMBL4090240	165197	0	None	-4	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c1C	10.1021/acs.jmedchem.6b01559
	9995943	207316	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Partial agonist activity at human GPR40 expressed in CHO cells assessed as fatty acid-induced calcium mobilization by FLIPR assayPartial agonist activity at human GPR40 expressed in CHO cells assessed as fatty acid-induced calcium mobilization by FLIPR assay	ChEMBL	317	4	1	4	3.5	O=C1NC(=O)C(Cc2ccc(Oc3ccc(F)cc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL598935	207316	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Partial agonist activity at human GPR40 expressed in CHO cells assessed as fatty acid-induced calcium mobilization by FLIPR assayPartial agonist activity at human GPR40 expressed in CHO cells assessed as fatty acid-induced calcium mobilization by FLIPR assay	ChEMBL	317	4	1	4	3.5	O=C1NC(=O)C(Cc2ccc(Oc3ccc(F)cc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	3514336	52756	15	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	5	1	3	4.0	O=C(O)C1CC(=O)N(c2ccc(OCc3ccc(Cl)cc3Cl)cc2)C1	10.1021/acs.jmedchem.6b01559
	CHEMBL1532576	52756	15	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	5	1	3	4.0	O=C(O)C1CC(=O)N(c2ccc(OCc3ccc(Cl)cc3Cl)cc2)C1	10.1021/acs.jmedchem.6b01559
	24825486	93575	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1cccc(NCc2ccc(-c3ccccc3)cc2)c1	10.1016/j.bmcl.2006.12.084
	CHEMBL232192	93575	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1cccc(NCc2ccc(-c3ccccc3)cc2)c1	10.1016/j.bmcl.2006.12.084
	118623088	148905	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883407	148905	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	57522038	10659	60	None	-1995	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FFAR1 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at FFAR1 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	10659	60	None	-1995	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FFAR1 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at FFAR1 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	10659	60	None	-1995	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at FFAR1 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at FFAR1 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	24825498	159864	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	358	6	2	3	4.4	O=C(O)CCc1ccc(NCc2cc(C(F)(F)F)cnc2Cl)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL397613	159864	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	358	6	2	3	4.4	O=C(O)CCc1ccc(NCc2cc(C(F)(F)F)cnc2Cl)cc1	10.1016/j.bmcl.2006.12.084
	24825497	168645	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	273	6	2	2	3.5	O=C(O)CCc1ccc(NCc2cccc(F)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL414895	168645	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	273	6	2	2	3.5	O=C(O)CCc1ccc(NCc2cccc(F)c2)cc1	10.1016/j.bmcl.2006.12.084
	127033354	145909	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	214	3	1	1	2.5	O=C(O)CCc1ccc(C#CC2CC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786964	145909	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	214	3	1	1	2.5	O=C(O)CCc1ccc(C#CC2CC2)cc1	10.1021/acs.jmedchem.5b01962
	145973087	171480	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	385	7	2	5	3.5	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3cccc(F)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4217225	171480	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	385	7	2	5	3.5	O=C(O)CCc1ccc(NC(=O)c2nnc(Cc3cccc(F)c3)s2)cc1	10.1016/j.ejmech.2017.09.019
	145987309	173881	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@H](CC(=O)O)c1ccc(OC[C@@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4289942	173881	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@H](CC(=O)O)c1ccc(OC[C@@H]2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	127046665	146538	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)n1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798520	146538	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)n1	10.1016/j.ejmech.2016.03.054
	145961656	168111	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	400	6	1	5	4.3	O=C1NC(=O)C(Cc2ccc(OCCn3ccc4ccc(Cl)cc43)cc2)S1	10.1016/j.bmcl.2018.03.051
	CHEMBL4125720	168111	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assayTransactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 secs for 100 secs by FLIPR assay	ChEMBL	400	6	1	5	4.3	O=C1NC(=O)C(Cc2ccc(OCCn3ccc4ccc(Cl)cc43)cc2)S1	10.1016/j.bmcl.2018.03.051
	46231433	207346	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	315	4	1	4	3.7	O=C1NC(=O)C(Cc2ccc(Sc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL599068	207346	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	315	4	1	4	3.7	O=C1NC(=O)C(Cc2ccc(Sc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	54583582	68938	0	None	2	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	431	6	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OC2CCCc3nc(-c4ccc(C)cc4)sc32)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777872	68938	0	None	2	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	431	6	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OC2CCCc3nc(-c4ccc(C)cc4)sc32)cc1	10.1016/j.bmcl.2011.03.114
	145978511	170448	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	460	9	1	5	4.8	CCOc1ccc(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(Cl)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4204628	170448	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	460	9	1	5	4.8	CCOc1ccc(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(Cl)c1	10.1016/j.ejmech.2017.07.001
	44409877	81783	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	346	8	2	3	4.5	NC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL203334	81783	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	346	8	2	3	4.5	NC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	148485044	182149	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	453	11	2	5	5.2	COCCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4574808	182149	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	453	11	2	5	5.2	COCCOc1cc(C)c(-c2cccc(CNc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	155528599	178133	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	385	7	2	3	5.2	O=C(O)COc1ccc(NCc2ccc(Cl)c(-c3ccccc3)c2)cc1F	10.1016/j.ejmech.2019.06.087
	CHEMBL4461611	178133	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	385	7	2	3	5.2	O=C(O)COc1ccc(NCc2ccc(Cl)c(-c3ccccc3)c2)cc1F	10.1016/j.ejmech.2019.06.087
	561372	65601	65	None	20	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm101405t
	CHEMBL1688452	65601	65	None	20	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm101405t
	90151297	163979	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	513	6	1	5	5.7	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(Cl)ccc4F)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4075946	163979	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	513	6	1	5	5.7	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cc(Cl)ccc4F)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	57325916	80882	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	488	11	1	4	6.5	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022581	80882	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	488	11	1	4	6.5	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	24857286	8405	72	None	-3	3	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2018.07.048
	6484	8405	72	None	-3	3	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2018.07.048
	CHEMBL1829174	8405	72	None	-3	3	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2018.07.048
	DB12491	8405	72	None	-3	3	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2018.07.048
	57521811	83041	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	CHEMBL2058522	83041	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	25150114	191939	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	266	3	1	2	2.9	Cc1cccc(C#Cc2ccc(OCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL485713	191939	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	266	3	1	2	2.9	Cc1cccc(C#Cc2ccc(OCC(=O)O)cc2)c1	10.1021/jm8010178
	54757627	72114	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	269	3	1	2	2.6	O=C(O)CCc1ccc(C#Cc2ccnc(F)c2)cc1	10.1021/jm2005699
	CHEMBL1829158	72114	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	269	3	1	2	2.6	O=C(O)CCc1ccc(C#Cc2ccnc(F)c2)cc1	10.1021/jm2005699
	127033020	145854	0	None	18	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786418	145854	0	None	18	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	118637973	169522	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	3	7.1	CSc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4171391	169522	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	3	7.1	CSc1cccc(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	54586484	68928	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777862	68928	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serum	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	90644288	118732	0	None	20	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288346	118732	0	None	20	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	145965661	170877	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	450	7	1	4	4.8	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3C(F)(F)F)c2)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4209622	170877	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	450	7	1	4	4.8	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(-c3ccccc3C(F)(F)F)c2)cc1	10.1016/j.ejmech.2017.07.001
	71613311	96769	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1cccc(C)c1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381305	96769	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1cccc(C)c1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	23157589	65617	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	373	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(CN(C)c2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688467	65617	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	373	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(CN(C)c2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	168285003	198304	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	492	11	1	4	7.2	Cc1ccc(OCCC2CCCCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5194153	198304	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	492	11	1	4	7.2	Cc1ccc(OCCC2CCCCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	137658243	166396	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	327	6	1	4	3.9	COc1ccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4103345	166396	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	327	6	1	4	3.9	COc1ccc(Oc2ccc(N3CCC[C@H]3CC(=O)O)cc2)cc1	10.1021/acs.jmedchem.6b01559
	145993621	174162	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cccc(Cl)c3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4294975	174162	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	386	6	1	4	4.1	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3cccc(Cl)c3O2)cc1	10.1016/j.bmc.2018.10.019
	1049	7151	75	None	1	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	4618	7151	75	None	1	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	5280934	7151	75	None	1	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	CHEMBL8739	7151	75	None	1	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	DB00132	7151	75	None	1	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	164616580	192106	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	297	4	2	1	4.3	Cc1cc(F)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4859651	192106	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay	ChEMBL	297	4	2	1	4.3	Cc1cc(F)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	90372613	174523	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4166625	174523	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302869	174523	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	443	7	1	4	6.0	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)ccn1	10.1021/acsmedchemlett.8b00149
	57521808	83038	0	None	3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL2058519	83038	0	None	3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	71562424	93320	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccc(F)cc2)cc1	10.1021/jm301470a
	CHEMBL2315544	93320	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccc(F)cc2)cc1	10.1021/jm301470a
	54757732	72116	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	281	4	1	3	2.5	COc1cc(C#Cc2ccc(CCC(=O)O)cc2)ccn1	10.1021/jm2005699
	CHEMBL1829160	72116	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	281	4	1	3	2.5	COc1cc(C#Cc2ccc(CCC(=O)O)cc2)ccn1	10.1021/jm2005699
	54582149	68580	0	None	33	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1773255	68580	0	None	33	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	57522038	10659	60	None	-1995	3	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	10659	60	None	-1995	3	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	10659	60	None	-1995	3	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	24857286	8405	72	None	-3	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2021.127969
	6484	8405	72	None	-3	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2021.127969
	CHEMBL1829174	8405	72	None	-3	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2021.127969
	DB12491	8405	72	None	-3	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2021.127969
	122185438	129457	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	325	8	1	4	3.7	CCOC(CC(=O)O)c1ccc(OCc2cccc(C#N)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604045	129457	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	325	8	1	4	3.7	CCOC(CC(=O)O)c1ccc(OCc2cccc(C#N)c2)cc1	10.1016/j.bmc.2015.07.028
	54582629	68930	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777864	68930	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	137646482	164530	0	None	2	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4082459	164530	0	None	2	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	127047529	146596	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	399	8	1	5	4.7	COc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798881	146596	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	399	8	1	5	4.7	COc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	127032539	145588	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	377	6	1	4	4.6	Cc1ccc(C)n1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	CHEMBL3781077	145588	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	377	6	1	4	4.6	Cc1ccc(C)n1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1016/j.bmc.2017.12.030
	145970371	171812	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	393	6	1	5	4.8	Cc1ccc(-c2c(C)noc2C)cc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.bmc.2017.12.030
	CHEMBL4226180	171812	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	393	6	1	5	4.8	Cc1ccc(-c2c(C)noc2C)cc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.bmc.2017.12.030
	54583098	68583	0	None	70	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/ml100106c
	CHEMBL1773258	68583	0	None	70	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/ml100106c
	44409927	84356	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	535	8	2	4	7.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)N[C@H](C)c2ccccc2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL208783	84356	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	535	8	2	4	7.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)N[C@H](C)c2ccccc2)cc1	10.1016/j.bmcl.2006.01.007
	23159951	65630	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	338	7	1	3	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3cccs3)c2)cc1	10.1021/jm101405t
	CHEMBL1688480	65630	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	338	7	1	3	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3cccs3)c2)cc1	10.1021/jm101405t
	75202609	163517	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	494	7	1	4	5.5	COc1ccc(F)c(N2CCC(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4070443	163517	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	494	7	1	4	5.5	COc1ccc(F)c(N2CCC(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	46231483	207575	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	311	4	1	4	2.8	O=C1NC(=O)C(Cc2ccc(C(=O)c3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL600658	207575	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	311	4	1	4	2.8	O=C1NC(=O)C(Cc2ccc(C(=O)c3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	145950191	169716	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	460	7	1	5	4.5	CC#CC(CC(=O)O)c1ccc(OCc2cnc(C(=O)N3CCc4ccccc4C3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4174315	169716	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	460	7	1	5	4.5	CC#CC(CC(=O)O)c1ccc(OCc2cnc(C(=O)N3CCc4ccccc4C3)s2)cc1	10.1016/j.ejmech.2018.04.023
	90372616	149011	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	145947998	174495	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4171104	174495	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302546	174495	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cn2)c1	10.1021/acsmedchemlett.8b00149
	155541840	179836	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	381	8	2	4	4.6	COc1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4519415	179836	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	381	8	2	4	4.6	COc1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	145975522	170320	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3ccc(F)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	CHEMBL4202901	170320	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR methodAgonist activity at human GPR40/FFA1 expressed in CHO cells assessed as increase in calcium flux at 1 uM by Fluo-8 AM dye based FLIPR method	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(NC(=O)c2nnc(COc3ccc(F)cc3)s2)cc1	10.1016/j.ejmech.2017.09.019
	131986112	171196	0	None	-3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccc(OCCOC)c4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4213548	171196	0	None	-3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccc(OCCOC)c4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	145950447	169765	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4175272	169765	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	155516498	176901	0	None	3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4443853	176901	0	None	3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	444	9	1	3	6.1	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@H](F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	132606863	164602	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4083365	164602	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
	122193735	130746	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	410	8	1	4	5.2	COc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2018.07.050
	CHEMBL3628755	130746	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	410	8	1	4	5.2	COc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2018.07.050
	142738551	168820	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	299	4	2	1	4.5	O=C(O)CCc1ccc2[nH]c(-c3ccccc3Cl)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4160141	168820	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	299	4	2	1	4.5	O=C(O)CCc1ccc2[nH]c(-c3ccccc3Cl)cc2c1	10.1021/acsmedchemlett.7b00460
	71612683	96746	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381281	96746	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
	1052	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	3323	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	5280450	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	CHEMBL267476	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	DB14104	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40Agonist activity at GPR40	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	122184686	129239	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	358	7	1	5	4.0	O=C(O)CCc1ccc(OCc2nc(-c3ccc(Cl)cc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601003	129239	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	358	7	1	5	4.0	O=C(O)CCc1ccc(OCc2nc(-c3ccc(Cl)cc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	168281295	197582	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	422	10	1	4	5.3	O=C(O)COc1ccc(OCc2cccc(-c3ccc(OCC4CC4)cc3)c2)cc1F	10.1016/j.bmc.2022.116615
	CHEMBL5183783	197582	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	422	10	1	4	5.3	O=C(O)COc1ccc(OCc2cccc(-c3ccc(OCC4CC4)cc3)c2)cc1F	10.1016/j.bmc.2022.116615
	168294961	199196	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	382	8	1	4	4.5	COc1cccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5208111	199196	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	382	8	1	4	4.5	COc1cccc(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	23111754	80823	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/ml1000855
	CHEMBL2022245	80823	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAAgonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/ml1000855
	1052	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	3323	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	5280450	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	CHEMBL267476	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	DB14104	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	90644289	118733	0	None	-8	2	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	367	7	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288347	118733	0	None	-8	2	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	367	7	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	145947764	174481	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4cccc5c4CCN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4238097	174481	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4cccc5c4CCN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4302391	174481	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4cccc5c4CCN(Cc4ccccc4)C5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	134153562	159502	0	None	-758	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	159502	0	None	-758	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	118637974	168817	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	398	6	1	2	6.4	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3ccccc3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	CHEMBL4160127	168817	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	398	6	1	2	6.4	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3ccccc3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	134130787	149044	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	471	7	1	4	6.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C#N)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884916	149044	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	471	7	1	4	6.4	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C#N)c1	10.1021/acsmedchemlett.6b00443
	155527626	178010	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	554	9	1	3	9.0	COc1ccc(F)c(-c2ccc3c(c2C2=CCCC2(C)C)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4459709	178010	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	554	9	1	3	9.0	COc1ccc(F)c(-c2ccc3c(c2C2=CCCC2(C)C)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	46231844	207315	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	430	4	1	5	5.1	Cc1cc(Oc2ncc(C(F)(F)F)cc2Cl)cc(C)c1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	CHEMBL598934	207315	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	430	4	1	5	5.1	Cc1cc(Oc2ncc(C(F)(F)F)cc2Cl)cc(C)c1CC1SC(=O)NC1=O	10.1016/j.bmcl.2009.10.052
	46231487	209226	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	4	1	4	3.7	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1	10.1016/j.bmcl.2009.10.052
	CHEMBL611084	209226	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	4	1	4	3.7	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1	10.1016/j.bmcl.2009.10.052
	118645756	188241	7	None	-2	3	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulationAgonist activity at rat GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulation	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764485	188241	7	None	-2	3	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity at rat GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulationAgonist activity at rat GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulation	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	155527487	177995	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4459517	177995	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	561372	65601	65	None	20	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688452	65601	65	None	20	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	145978233	170370	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	432	7	2	4	5.6	COc1cc(C)c(-c2cccc(COc3ccc4c(c3)C(O)CC4CC(=O)O)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4203471	170370	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	432	7	2	4	5.6	COc1cc(C)c(-c2cccc(COc3ccc4c(c3)C(O)CC4CC(=O)O)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	145976608	170536	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2ccccc2F)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4205537	170536	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2ccccc2F)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2017.07.001
	54585039	68577	5	None	17	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/ml100106c
	CHEMBL1773252	68577	5	None	17	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/ml100106c
	1052	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	3323	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	5280450	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	CHEMBL267476	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	DB14104	9101	85	None	-5	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2008.10.085
	134151151	161299	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	513	10	1	4	6.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccccc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3963542	161299	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	513	10	1	4	6.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccccc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990756	161299	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	513	10	1	4	6.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccccc3)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	51031010	163410	0	None	3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	409	6	1	4	5.0	COc1ccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c(C)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4069191	163410	0	None	3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	409	6	1	4	5.0	COc1ccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c(C)c1	10.1021/acs.jmedchem.6b01559
	51357276	188786	0	None	-10	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4780641	188786	0	None	-10	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	71612896	96757	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	552	9	1	7	5.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381293	96757	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	552	9	1	7	5.2	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	46231653	207892	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL603064	207892	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	3.8	O=C1NC(=O)C(Cc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)S1	10.1016/j.bmcl.2009.10.052
	118642379	148897	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883354	148897	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	71615468	96766	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	576	9	1	7	5.4	CS(=O)(=O)CCCOc1ccc(-c2ccc(F)c(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381302	96766	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	576	9	1	7	5.4	CS(=O)(=O)CCCOc1ccc(-c2ccc(F)c(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	71613316	96774	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	422	4	1	4	5.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(-c2ccccc2Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381310	96774	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	422	4	1	4	5.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@H](c1cccc(-c2ccccc2Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	75511302	129231	3	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	341	7	1	4	4.1	O=C(O)CCc1ccc(OCc2coc(-c3cccc(F)c3)n2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600995	129231	3	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	341	7	1	4	4.1	O=C(O)CCc1ccc(OCc2coc(-c3cccc(F)c3)n2)cc1	10.1016/j.bmcl.2015.06.018
	122185445	129467	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	370	7	1	3	5.8	CCOC(CC(=O)O)c1ccc(Oc2ccc(Cl)c3ccccc23)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604055	129467	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	370	7	1	3	5.8	CCOC(CC(=O)O)c1ccc(Oc2ccc(Cl)c3ccccc23)cc1	10.1016/j.bmc.2015.07.028
	58218542	163545	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	297	5	1	3	3.9	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4070703	163545	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	297	5	1	3	3.9	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
	122185449	129471	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	327	7	1	4	3.7	CCO[C@@H](CC(=O)O)c1ccc(OC2CCc3ncccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604059	129471	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	327	7	1	4	3.7	CCO[C@@H](CC(=O)O)c1ccc(OC2CCc3ncccc32)cc1	10.1016/j.bmc.2015.07.028
	58218638	164215	0	None	-75	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4078852	164215	0	None	-75	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	51350272	65615	0	None	107	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albumin	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1688465	65615	0	None	107	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.5 % bovine serum albumin	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	11739868	82323	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	359	7	2	3	5.3	O=C(O)[C@@H]1C[C@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL204455	82323	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	359	7	2	3	5.3	O=C(O)[C@@H]1C[C@H]1c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2006.01.007
	25149900	179402	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	268	3	2	3	2.3	O=C(O)COc1ccc(C#Cc2cccc(O)c2)cc1	10.1021/jm8010178
	CHEMBL449321	179402	1	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	268	3	2	3	2.3	O=C(O)COc1ccc(C#Cc2cccc(O)c2)cc1	10.1021/jm8010178
	23136363	65607	0	None	14	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL1688458	65607	0	None	14	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	137661929	166285	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	410	9	1	4	6.2	CCOC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4101950	166285	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	410	9	1	4	6.2	CCOC(CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cccc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	145959598	169134	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	459	7	1	4	5.1	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCc4ccccc4C3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4165046	169134	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	459	7	1	4	5.1	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCc4ccccc4C3)s2)cc1	10.1016/j.ejmech.2018.04.023
	24857286	8405	72	None	-3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
	6484	8405	72	None	-3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
	CHEMBL1829174	8405	72	None	-3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
	DB12491	8405	72	None	-3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
	145964820	171081	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	440	8	1	5	4.4	COc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4212170	171081	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	440	8	1	5	4.4	COc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	23136363	65607	0	None	14	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/ml100106c
	CHEMBL1688458	65607	0	None	14	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/ml100106c
	58218672	163500	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	327	5	1	3	4.6	Cc1ccccc1Sc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4070270	163500	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	327	5	1	3	4.6	Cc1ccccc1Sc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	57325678	80829	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	387	6	1	3	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(n2)CCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022250	80829	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	387	6	1	3	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(n2)CCC3CC(=O)O)c1	10.1021/jm2012968
	58319142	93293	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	280	4	2	2	2.6	O=C(O)CCc1ccc(C#Cc2ccccc2CO)cc1	10.1021/jm301470a
	CHEMBL2315249	93293	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	280	4	2	2	2.6	O=C(O)CCc1ccc(C#Cc2ccccc2CO)cc1	10.1021/jm301470a
	86803224	129229	24	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	337	7	1	4	4.2	Cc1oc(-c2ccccc2)nc1COc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600993	129229	24	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	337	7	1	4	4.2	Cc1oc(-c2ccccc2)nc1COc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2015.06.018
	57398938	76801	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939653	76801	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.bmcl.2011.10.118
	134130352	148923	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883532	148923	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	153213696	182292	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	351	7	2	3	4.6	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3)c2)cc1F	10.1016/j.ejmech.2019.06.087
	CHEMBL4577954	182292	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	351	7	2	3	4.6	O=C(O)COc1ccc(NCc2cccc(-c3ccccc3)c2)cc1F	10.1016/j.ejmech.2019.06.087
	25150118	193469	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	295	4	1	3	3.0	O=C(O)CCc1ccc(C#Cc2cccc([N+](=O)[O-])c2)cc1	10.1021/jm8010178
	CHEMBL488396	193469	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	295	4	1	3	3.0	O=C(O)CCc1ccc(C#Cc2cccc([N+](=O)[O-])c2)cc1	10.1021/jm8010178
	44409916	145676	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	434	7	2	4	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(C(C)CC(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL378275	145676	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	434	7	2	4	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(C(C)CC(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	57393689	76788	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	380	8	1	3	5.0	COc1ccc(COc2ccc(C(CC(=O)O)c3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939640	76788	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	380	8	1	3	5.0	COc1ccc(COc2ccc(C(CC(=O)O)c3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2011.10.118
	137632053	163136	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	386	8	1	4	5.2	COc1ccc(F)c(-c2cccc(COc3ccc(CCC(=O)O)s3)c2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4065959	163136	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	386	8	1	4	5.2	COc1ccc(F)c(-c2cccc(COc3ccc(CCC(=O)O)s3)c2)c1	10.1021/acs.jmedchem.6b01357
	122185433	129442	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	391	9	1	5	3.1	CCOC(CC(=O)NS(C)(=O)=O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604031	129442	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	391	9	1	5	3.1	CCOC(CC(=O)NS(C)(=O)=O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmc.2015.07.028
	127051658	147064	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccccc3F)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805888	147064	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccccc3F)s2)cc1	10.1016/j.bmc.2016.04.065
	127050770	147069	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	419	8	2	6	3.7	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccc(F)c(F)c3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805952	147069	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	419	8	2	6	3.7	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccc(F)c(F)c3)s2)cc1	10.1016/j.bmc.2016.04.065
	145991380	173764	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	428	7	1	6	3.9	Cn1ccnc1C(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4287775	173764	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	428	7	1	6	3.9	Cn1ccnc1C(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	155513821	176593	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4439462	176593	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	146763588	180569	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	515	12	2	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4537797	180569	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	515	12	2	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	90151022	165109	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	7	1	6	5.1	COc1cccc(F)c1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	CHEMBL4089313	165109	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	509	7	1	6	5.1	COc1cccc(F)c1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	118144976	178033	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	446	8	1	3	6.5	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4460109	178033	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	446	8	1	3	6.5	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	54586484	68928	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777862	68928	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminAgonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albumin	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	59541	183115	92	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells by FLIPR calcium assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells by FLIPR calcium assay	ChEMBL	168	3	1	2	1.9	O=C(O)CSc1ccccc1	10.1016/j.bmcl.2021.127969
	CHEMBL459548	183115	92	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells by FLIPR calcium assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells by FLIPR calcium assay	ChEMBL	168	3	1	2	1.9	O=C(O)CSc1ccccc1	10.1016/j.bmcl.2021.127969
	90655861	118027	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	506	10	1	5	7.1	CC[C@H](CC(=O)O)c1ccnc(OCc2ccc(-c3cc(OC)ncc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/ml4005123
	CHEMBL3265145	118027	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	506	10	1	5	7.1	CC[C@H](CC(=O)O)c1ccnc(OCc2ccc(-c3cc(OC)ncc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/ml4005123
	73891117	121040	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	522	8	1	4	7.1	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(c5ccccc5)C(C)C4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3330550	121040	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	522	8	1	4	7.1	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(c5ccccc5)C(C)C4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmcl.2016.10.074
	6483	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66553168	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	CHEMBL2386353	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	131986035	170836	0	None	5	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	612	10	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4209136	170836	0	None	5	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	612	10	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	51350138	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2005699
	CHEMBL1688473	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2005699
	51350138	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPRAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPR	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL1688473	65623	0	None	660	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPRAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.1% BSA by FLIPR	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	146316684	178344	0	None	-3	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4464769	178344	0	None	-3	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	68194743	189327	12	None	-5	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4787498	189327	12	None	-5	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	6483	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66553168	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	CHEMBL2386353	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	45107281	125901	3	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1021/ml500391n
	CHEMBL3427702	125901	3	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1021/ml500391n
	45107281	125901	3	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427702	125901	3	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	67087246	189656	5	None	-12	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4791842	189656	5	None	-12	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	23157191	65616	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	359	7	2	2	5.6	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688466	65616	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	359	7	2	2	5.6	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	59590895	118032	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	521	9	1	5	6.9	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
	CHEMBL3265150	118032	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in mouse A9 cells assessed as inositol phosphate accumulation using [myo-3H]inositol after 1 hr by scintillation counting in presence of 0.3% human serum albumin	ChEMBL	521	9	1	5	6.9	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
	11674915	65636	1	None	1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL1688486	65636	1	None	1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1016/j.bmcl.2014.04.065
	118638010	174344	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165008	174344	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300503	174344	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	146316684	178344	0	None	3	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4464769	178344	0	None	3	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	44409677	148009	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	447	6	3	5	5.4	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NO)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL382915	148009	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	447	6	3	5	5.4	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NO)cc1	10.1016/j.bmcl.2006.01.007
	46854655	7183	47	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml300133f
	6485	7183	47	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml300133f
	CHEMBL1829173	7183	47	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml300133f
	155527487	177995	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4459517	177995	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	460	8	1	3	6.8	COc1ccc(F)c(-c2ccc3c(c2)CC[C@@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	90150977	162948	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	521	7	1	5	6.2	CC(C)c1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4063905	162948	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	521	7	1	5	6.2	CC(C)c1ccc(F)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	15659413	105501	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	294	6	3	5	3.3	CC(C)CC(=O)c1c(O)cc(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL277845	105501	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	294	6	3	5	3.3	CC(C)CC(=O)c1c(O)cc(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	57521702	83037	0	None	11	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	CHEMBL2058518	83037	0	None	11	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	57521916	83048	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058529	83048	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	54757516	72103	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	285	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2cccnc2Cl)cc1	10.1021/jm2005699
	CHEMBL1829148	72103	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	285	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2cccnc2Cl)cc1	10.1021/jm2005699
	44634023	72099	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2cccnc2)cc1	10.1021/jm2005699
	CHEMBL1829144	72099	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2cccnc2)cc1	10.1021/jm2005699
	15659413	105501	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	294	6	3	5	3.3	CC(C)CC(=O)c1c(O)cc(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL277845	105501	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	294	6	3	5	3.3	CC(C)CC(=O)c1c(O)cc(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	122193975	130757	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	502	12	1	6	4.7	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL3629049	130757	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	502	12	1	6	4.7	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	67087173	189239	0	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4786335	189239	0	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
	134130696	148915	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	CHEMBL3883449	148915	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	490	9	1	4	6.7	COCc1cc(C2CCc3ccc([C@@H](CC(=O)O)C4CC4)cc3O2)ccc1-c1cc(OC)ccc1F	10.1021/acsmedchemlett.6b00443
	127031413	145635	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	421	8	1	5	5.0	CCOc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-n1c(C)ccc1C	10.1016/j.bmc.2016.03.014
	CHEMBL3781733	145635	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay	ChEMBL	421	8	1	5	5.0	CCOc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-n1c(C)ccc1C	10.1016/j.bmc.2016.03.014
	145983006	172258	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	499	13	1	7	5.1	Cc1cc(OCCCO[N+](=O)[O-])cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2018.07.050
	CHEMBL4240026	172258	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	499	13	1	7	5.1	Cc1cc(OCCCO[N+](=O)[O-])cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2018.07.050
	71615669	96778	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	430	4	1	4	5.7	Cc1cc(C)c(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(C)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381314	96778	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	430	4	1	4	5.7	Cc1cc(C)c(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(C)c1	10.1016/j.bmcl.2013.03.060
	86803186	129240	2	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	392	7	1	5	4.4	O=C(O)CCc1ccc(OCc2nc(-c3ccc(C(F)(F)F)cc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601004	129240	2	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	392	7	1	5	4.4	O=C(O)CCc1ccc(OCc2nc(-c3ccc(C(F)(F)F)cc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	168291030	198677	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	424	10	1	4	5.6	CCCOc1ccc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5199948	198677	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	424	10	1	4	5.6	CCCOc1ccc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c1	10.1016/j.bmc.2022.116615
	145956739	168916	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	468	8	1	5	4.4	O=C(O)CCc1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4161630	168916	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	468	8	1	5	4.4	O=C(O)CCc1ccc(OCc2ccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	145986077	173230	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	342	4	1	2	4.7	Cc1ccccc1-c1cccc(COc2ccc(C#CC(=O)O)cc2)c1	10.1016/j.ejmech.2018.08.075
	CHEMBL4277789	173230	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	342	4	1	2	4.7	Cc1ccccc1-c1cccc(COc2ccc(C#CC(=O)O)cc2)c1	10.1016/j.ejmech.2018.08.075
	137629985	167803	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	544	12	1	6	5.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccncc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4101306	167803	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	544	12	1	6	5.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccncc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4116362	167803	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	544	12	1	6	5.9	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccncc3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	137650498	164101	0	None	-2	2	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4077353	164101	0	None	-2	2	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
	137640163	163627	0	None	-5	2	Mouse	4.2	pEC50	=	4.2	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4071523	163627	0	None	-5	2	Mouse	4.2	pEC50	=	4.2	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	127025285	144449	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	457	6	1	4	5.8	O=C1NC(=O)C(Cc2ccc(OCc3cccc(-c4ccc(C(F)(F)F)cc4)c3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3758553	144449	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	457	6	1	4	5.8	O=C1NC(=O)C(Cc2ccc(OCc3cccc(-c4ccc(C(F)(F)F)cc4)c3)cc2)S1	10.1016/j.ejmech.2015.12.049
	73356514	97150	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386368	97150	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	54757514	72101	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	265	3	1	2	2.8	Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)n1	10.1021/jm2005699
	CHEMBL1829146	72101	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	265	3	1	2	2.8	Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)n1	10.1021/jm2005699
	44319268	113948	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	5	1	4	3.2	O=C1NC(=O)C(Cc2ccc(OCc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL316370	113948	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	313	5	1	4	3.2	O=C1NC(=O)C(Cc2ccc(OCc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	67058273	125907	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	340	7	1	3	4.7	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCCc3ccccc32)cc1	10.1021/ml500391n
	CHEMBL3427708	125907	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	340	7	1	3	4.7	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCCc3ccccc32)cc1	10.1021/ml500391n
	67058273	125907	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	340	7	1	3	4.7	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCCc3ccccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427708	125907	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	340	7	1	3	4.7	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCCc3ccccc32)cc1	10.1016/j.bmc.2015.07.028
	121294396	186439	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	603	12	1	7	6.5	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cccc(C(CC(=O)O)OC)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4743254	186439	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	603	12	1	7	6.5	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cccc(C(CC(=O)O)OC)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	118719721	122442	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	516	12	1	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2014.11.016
	CHEMBL3353742	122442	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	516	12	1	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2014.11.016
	118719721	122442	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	516	12	1	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	CHEMBL3353742	122442	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR methodAgonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR method	ChEMBL	516	12	1	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.09.010
	118719721	122442	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	516	12	1	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3353742	122442	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	516	12	1	6	5.0	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2015.10.011
	57400636	76794	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	294	6	1	2	3.8	CC#CC(CC(=O)O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939646	76794	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	294	6	1	2	3.8	CC#CC(CC(=O)O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2011.10.118
	90151177	166511	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	491	7	1	6	5.0	COc1cccc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4104738	166511	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	491	7	1	6	5.0	COc1cccc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	57390187	76795	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	308	7	1	2	3.9	CC#CC(CC(=O)O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939647	76795	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	308	7	1	2	3.9	CC#CC(CC(=O)O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2011.10.118
	137640032	163709	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.4	Cc1ccccc1Cc1ccc(N2[C@@H](C)CC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4072491	163709	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	323	5	1	2	4.4	Cc1ccccc1Cc1ccc(N2[C@@H](C)CC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	90151279	165019	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	495	6	1	5	5.6	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccc(Cl)cc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4088375	165019	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	495	6	1	5	5.6	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4ccc(Cl)cc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	118688890	197023	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)[C@H](CC(=O)O)CO3)c1	10.1016/j.bmc.2022.116615
	CHEMBL5175124	197023	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)[C@H](CC(=O)O)CO3)c1	10.1016/j.bmc.2022.116615
	131986297	170984	0	None	1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4210878	170984	0	None	1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	498	7	1	5	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	46231840	207313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	402	4	1	5	4.7	O=C1NC(=O)C(Cc2ccc(Oc3ncc(Cl)cc3Cl)cc2Cl)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL598917	207313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	402	4	1	5	4.7	O=C1NC(=O)C(Cc2ccc(Oc3ncc(Cl)cc3Cl)cc2Cl)S1	10.1016/j.bmcl.2009.10.052
	118737972	125909	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	370	9	1	4	4.7	CCOc1cccc2c1CC[C@H]2Oc1ccc([C@H](CC(=O)O)OCC)cc1	10.1021/ml500391n
	CHEMBL3427710	125909	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	370	9	1	4	4.7	CCOc1cccc2c1CC[C@H]2Oc1ccc([C@H](CC(=O)O)OCC)cc1	10.1021/ml500391n
	118737972	125909	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	370	9	1	4	4.7	CCOc1cccc2c1CC[C@H]2Oc1ccc([C@H](CC(=O)O)OCC)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427710	125909	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	370	9	1	4	4.7	CCOc1cccc2c1CC[C@H]2Oc1ccc([C@H](CC(=O)O)OCC)cc1	10.1016/j.bmc.2015.07.028
	58172969	129458	3	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	345	9	1	5	3.7	CCOC(CC(=O)O)c1ccc(OCc2cccc([N+](=O)[O-])c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604046	129458	3	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	345	9	1	5	3.7	CCOC(CC(=O)O)c1ccc(OCc2cccc([N+](=O)[O-])c2)cc1	10.1016/j.bmc.2015.07.028
	23136363	65607	0	None	14	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688458	65607	0	None	14	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	145973478	171371	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	454	9	1	5	4.8	CCOc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4215675	171371	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	454	9	1	5	4.8	CCOc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	71612895	96707	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	398	3	1	4	4.3	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cc(F)cc(C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2380322	96707	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	398	3	1	4	4.3	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cc(F)cc(C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	75204487	165746	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	496	8	1	5	5.0	COc1ccc(F)c(N2CC[C@@H](COc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4096102	165746	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	496	8	1	5	5.0	COc1ccc(F)c(N2CC[C@@H](COc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C2)c1	10.1021/acs.jmedchem.7b00982
	134144929	157228	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay	ChEMBL	418	5	2	4	6.2	O=C(O)CCc1ccc2oc(Nc3c(Cl)c(Cl)cc(Cl)c3Cl)nc2c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3954105	157228	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assayAgonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay	ChEMBL	418	5	2	4	6.2	O=C(O)CCc1ccc2oc(Nc3c(Cl)c(Cl)cc(Cl)c3Cl)nc2c1	10.1016/j.bmcl.2016.10.074
	57521809	83039	0	None	-13	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058520	83039	0	None	-13	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL4210970	83039	0	None	-13	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	57521914	83046	0	None	6	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058527	83046	0	None	6	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	73777153	149601	0	None	-81	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	149601	0	None	-81	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	54582148	68571	4	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(COc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1773246	68571	4	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(COc2ccccc2)cc1	10.1021/ml100106c
	134138318	154798	0	None	-23	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	154798	0	None	-23	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	57393691	76793	1	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939645	76793	1	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	118144976	178033	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	446	8	1	3	6.5	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4460109	178033	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	446	8	1	3	6.5	COc1ccc(F)c(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	162652399	187007	0	None	-3	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4749949	187007	0	None	-3	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	1050	8683	94	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2006.01.007
	11595431	8683	94	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2006.01.007
	CHEMBL207881	8683	94	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2006.01.007
	127034369	145534	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	399	6	1	5	4.8	Cc1nc(-c2cccc(F)c2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	CHEMBL3780456	145534	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	399	6	1	5	4.8	Cc1nc(-c2cccc(F)c2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	137646308	164650	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	295	4	1	3	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4083913	164650	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	295	4	1	3	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)s1	10.1021/acs.jmedchem.6b01357
	145992631	173644	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	392	8	1	5	4.1	CCOC(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4285740	173644	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	392	8	1	5	4.1	CCOC(CC(=O)O)c1ccc(OCC2COc3ccc(Cl)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	137635388	162603	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	407	6	1	3	5.8	O=C(O)CC1CCCCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4059947	162603	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	407	6	1	3	5.8	O=C(O)CC1CCCCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	145957539	169020	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	482	7	1	3	7.3	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(OC(F)(F)F)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163496	169020	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	482	7	1	3	7.3	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(OC(F)(F)F)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	46231386	206011	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	349	4	1	3	4.0	O=C1CC(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2)C(=O)N1	10.1016/j.bmcl.2009.10.052
	CHEMBL589992	206011	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	349	4	1	3	4.0	O=C1CC(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2)C(=O)N1	10.1016/j.bmcl.2009.10.052
	8852666	199461	26	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1ccccc1Nc1nc(N)nc(COc2ccc3c(C)cc(=O)oc3c2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL5219102	199461	26	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1ccccc1Nc1nc(N)nc(COc2ccc3c(C)cc(=O)oc3c2)n1	10.1016/j.ejmech.2022.114645
	57522038	10659	60	None	-1995	3	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	10659	60	None	-1995	3	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	10659	60	None	-1995	3	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137658671	166227	0	None	-7	2	Human	5.2	pEC50	=	5.2	Functional	Antagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assayAntagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay	ChEMBL	282	2	2	0	4.5	Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12	10.1021/acs.jmedchem.6b01593
	CHEMBL4101219	166227	0	None	-7	2	Human	5.2	pEC50	=	5.2	Functional	Antagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assayAntagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay	ChEMBL	282	2	2	0	4.5	Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12	10.1021/acs.jmedchem.6b01593
	122185443	129465	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	382	9	1	3	5.2	CCOC(CC(=O)O)c1ccc(OCCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604053	129465	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	382	9	1	3	5.2	CCOC(CC(=O)O)c1ccc(OCCc2ccc(Cl)c(Cl)c2)cc1	10.1016/j.bmc.2015.07.028
	90644289	118733	0	None	8	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	367	7	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288347	118733	0	None	8	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	367	7	1	4	5.0	Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	90644297	118741	0	None	32	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.2	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(C)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288355	118741	0	None	32	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.2	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(C)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	162676686	190265	0	None	-11	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4799453	190265	0	None	-11	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
	71615666	96775	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	388	4	1	4	4.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccccc2)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381311	96775	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	388	4	1	4	4.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccccc2)c1)O3	10.1016/j.bmcl.2013.03.060
	122193736	130747	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	424	9	1	4	5.6	CCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	CHEMBL3628756	130747	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay	ChEMBL	424	9	1	4	5.6	CCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.bmc.2015.10.011
	71449361	87435	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	400	8	1	3	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(-c3cccc(OC)c3)cc2)cc1	10.1021/ml300133f
	CHEMBL2151288	87435	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	400	8	1	3	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(-c3cccc(OC)c3)cc2)cc1	10.1021/ml300133f
	168282466	198036	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assay	ChEMBL	543	12	1	6	5.4	Cn1nc(COCc2ccccc2F)c2c1CCN(Cc1ccc(COc3ccc(CCC(=O)O)cc3)cc1)C2	10.1016/j.bmcl.2021.127969
	CHEMBL5190303	198036	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assay	ChEMBL	543	12	1	6	5.4	Cn1nc(COCc2ccccc2F)c2c1CCN(Cc1ccc(COc3ccc(CCC(=O)O)cc3)cc1)C2	10.1016/j.bmcl.2021.127969
	155529599	178235	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	458	8	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4cccc(OC)c4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4463298	178235	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	458	8	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4cccc(OC)c4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	137646337	164707	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	353	5	1	3	5.2	CC(C)(C)c1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4084441	164707	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	353	5	1	3	5.2	CC(C)(C)c1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	44319268	113948	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	313	5	1	4	3.2	O=C1NC(=O)C(Cc2ccc(OCc3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL316370	113948	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	313	5	1	4	3.2	O=C1NC(=O)C(Cc2ccc(OCc3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	118638016	174431	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163182	174431	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301725	174431	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)cc2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	145967091	170896	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	410	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4209845	170896	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	410	7	1	4	4.4	Cc1cccc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	44409844	81264	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	459	6	1	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)N(C)C)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL202835	81264	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	459	6	1	4	5.9	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)N(C)C)cc1	10.1016/j.bmcl.2006.01.007
	71613315	96773	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	422	4	1	4	5.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(-c2ccccc2Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381309	96773	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	422	4	1	4	5.5	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(-c2ccccc2Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	54757518	72106	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	283	3	1	2	2.9	Cc1cnc(F)c(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2005699
	CHEMBL1829150	72106	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	283	3	1	2	2.9	Cc1cnc(F)c(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2005699
	1622278	101779	10	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	CHEMBL254861	101779	10	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	127051659	146993	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccc(F)cc3)s2)cc1	10.1016/j.bmc.2016.04.065
	CHEMBL3805086	146993	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	401	8	2	6	3.5	O=C(O)CCc1ccc(OCc2nnc(C(=O)Nc3ccc(F)cc3)s2)cc1	10.1016/j.bmc.2016.04.065
	155565451	182374	11	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OC[C@H]2CC(=O)O	10.1016/j.bmcl.2021.127969
	CHEMBL4579901	182374	11	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assayAgonist activity at FFAR1 (unknown origin) expressed in CHO cells assessed as increase in calcium efflux by Fluo-4AM dye based FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OC[C@H]2CC(=O)O	10.1016/j.bmcl.2021.127969
	131986082	170933	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	454	7	1	7	4.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccnn4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4210243	170933	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	454	7	1	7	4.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccnn4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	58218608	163463	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	377	5	1	2	4.8	Cc1ccccc1Cc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4069764	163463	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	377	5	1	2	4.8	Cc1ccccc1Cc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	71613092	96760	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1ccc(F)c([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381296	96760	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1ccc(F)c([C@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	44409690	82348	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	420	7	2	4	5.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL204630	82348	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	420	7	2	4	5.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2006.01.007
	168272362	197429	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	422	10	1	4	5.3	O=C(O)COc1ccc(OCc2cccc(-c3cccc(OCC4CC4)c3)c2)cc1F	10.1016/j.bmc.2022.116615
	CHEMBL5181439	197429	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	422	10	1	4	5.3	O=C(O)COc1ccc(OCc2cccc(-c3cccc(OCC4CC4)c3)c2)cc1F	10.1016/j.bmc.2022.116615
	162657311	187633	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	427	9	1	4	5.1	COc1ccc(F)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4757231	187633	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	427	9	1	4	5.1	COc1ccc(F)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	57393690	76792	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939644	76792	1	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	324	7	1	3	3.9	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	134136175	149458	0	None	-51	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	149458	0	None	-51	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	131986090	171071	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	8	1	7	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(S(C)(=O)=O)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4212041	171071	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	542	8	1	7	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(S(C)(=O)=O)c(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	23136411	65606	0	None	11	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688457	65606	0	None	11	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	5849	6854	44	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assay	ChEMBL	216	10	2	2	3.0	CCCCCCCCCCC(C(=O)O)O	10.1039/C7MD00130D
	97783	6854	44	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assay	ChEMBL	216	10	2	2	3.0	CCCCCCCCCCC(C(=O)O)O	10.1039/C7MD00130D
	CHEMBL4278254	6854	44	None	1	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 15 mins by BRET assay	ChEMBL	216	10	2	2	3.0	CCCCCCCCCCC(C(=O)O)O	10.1039/C7MD00130D
	134134149	150153	0	None	-100	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	150153	0	None	-100	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	162644059	188603	0	None	45	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
	CHEMBL4778264	188603	0	None	45	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
	127033239	145517	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	387	6	1	6	4.7	Cc1nc(-c2ccsc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	CHEMBL3780232	145517	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	387	6	1	6	4.7	Cc1nc(-c2ccsc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	75511301	129241	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	342	7	1	5	3.5	O=C(O)CCc1ccc(OCc2nc(-c3ccc(F)cc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3601005	129241	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	342	7	1	5	3.5	O=C(O)CCc1ccc(OCc2nc(-c3ccc(F)cc3)no2)cc1	10.1016/j.bmcl.2015.06.018
	57705531	87442	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	464	9	1	3	7.3	CC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c(C(C)(C)C)c2)c1	10.1021/ml300133f
	CHEMBL2151295	87442	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	464	9	1	3	7.3	CC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c(C(C)(C)C)c2)c1	10.1021/ml300133f
	137640919	163851	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	331	5	1	3	4.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4074138	163851	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	331	5	1	3	4.6	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.6b01559
	137659517	166038	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	500	6	1	6	5.1	Cc1ccc(C#N)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4099189	166038	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	500	6	1	6	5.1	Cc1ccc(C#N)c(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)CC2)c1	10.1021/acs.jmedchem.7b00982
	168294722	199249	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	427	7	1	5	5.3	O=C(O)COc1ccc(COc2cccc(-c3nc4cc(Cl)ccc4o3)c2)cc1F	10.1016/j.ejmech.2021.114061
	CHEMBL5208754	199249	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayAgonist activity at human FFA1 expressed in CHO cells measured by FLIPR assay	ChEMBL	427	7	1	5	5.3	O=C(O)COc1ccc(COc2cccc(-c3nc4cc(Cl)ccc4o3)c2)cc1F	10.1016/j.ejmech.2021.114061
	1050	8683	94	None	-1	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 H137F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H137F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	11595431	8683	94	None	-1	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 H137F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H137F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	CHEMBL207881	8683	94	None	-1	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR40 H137F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calciumAgonist activity at human GPR40 H137F mutant expressed in HEK-EM 293 cells assessed as increase in intracellular calcium	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm0614782
	164616580	192106	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assay	ChEMBL	297	4	2	1	4.3	Cc1cc(F)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	CHEMBL4859651	192106	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assay	ChEMBL	297	4	2	1	4.3	Cc1cc(F)ccc1-c1cc2cc(CCC(=O)O)ccc2[nH]1	10.1021/acs.jmedchem.1c00031
	54584570	68923	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	344	5	1	2	5.2	O=C(O)CCc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777857	68923	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	344	5	1	2	5.2	O=C(O)CCc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	145983493	172283	0	None	-371	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4240607	172283	0	None	-371	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	46231717	207726	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	382	4	1	5	4.1	Cc1cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)nc(C(F)(F)F)c1	10.1016/j.bmcl.2009.10.052
	CHEMBL601848	207726	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	382	4	1	5	4.1	Cc1cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)nc(C(F)(F)F)c1	10.1016/j.bmcl.2009.10.052
	46231718	208458	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	402	4	1	5	4.4	O=C1NC(=O)C(Cc2ccc(Oc3ncc(C(F)(F)F)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL606206	208458	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	402	4	1	5	4.4	O=C1NC(=O)C(Cc2ccc(Oc3ncc(C(F)(F)F)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	118737971	125905	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@H]2CCc3ccccc32)cc1	10.1021/ml500391n
	CHEMBL3427706	125905	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@H]2CCc3ccccc32)cc1	10.1021/ml500391n
	118737971	125905	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@H]2CCc3ccccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427706	125905	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	326	7	1	3	4.3	CCO[C@@H](CC(=O)O)c1ccc(O[C@H]2CCc3ccccc32)cc1	10.1016/j.bmc.2015.07.028
	57325674	80827	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	372	6	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022249	80827	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	372	6	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CC3CC(=O)O)c1	10.1021/jm2012968
	127047530	146366	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	413	9	1	5	5.1	CCOc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3797383	146366	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	413	9	1	5	5.1	CCOc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	145966647	170968	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	468	10	1	5	5.2	CCCOc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4210719	170968	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	468	10	1	5	5.2	CCCOc1cc(C)c(-c2cccc(COc3ccc(S(=O)(=O)CC(=O)O)cc3)c2)c(C)c1	10.1016/j.ejmech.2017.07.001
	54582145	68567	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	361	8	2	3	5.0	COc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1773167	68567	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	361	8	2	3	5.0	COc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	122193736	130747	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	424	9	1	4	5.6	CCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL3628756	130747	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	424	9	1	4	5.6	CCOc1cc(C)c(-c2cccc(COc3ccc(OCC(=O)O)c(F)c3)c2)c(C)c1	10.1016/j.ejmech.2019.06.087
	155558174	181545	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	381	7	3	4	4.6	Cc1cc(O)ccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4561122	181545	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	381	7	3	4	4.6	Cc1cc(O)ccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	57706031	87443	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	478	10	1	3	7.7	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c(C(C)(C)C)c2)c1	10.1021/ml300133f
	CHEMBL2151296	87443	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	478	10	1	3	7.7	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c(C(C)(C)C)c2)c1	10.1021/ml300133f
	145992604	173612	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	362	4	1	2	5.0	O=C(O)C#Cc1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.ejmech.2018.08.075
	CHEMBL4285071	173612	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	362	4	1	2	5.0	O=C(O)C#Cc1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.ejmech.2018.08.075
	58218740	163224	0	None	-45	2	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	315	5	1	3	4.1	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2F)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4067052	163224	0	None	-45	2	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	315	5	1	3	4.1	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2F)cc1	10.1021/acs.jmedchem.6b01559
	137529983	170656	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	516	8	2	5	6.2	Cc1cc(OCC2CCOC2)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	CHEMBL4206879	170656	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay	ChEMBL	516	8	2	5	6.2	Cc1cc(OCC2CCOC2)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Nc1ccc([C@H]2C[C@@H]2C(=O)O)nc1	10.1021/acsmedchemlett.8b00343
	131986294	170620	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	464	7	1	5	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206445	170620	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	464	7	1	5	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	118623088	148905	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	CHEMBL3883407	148905	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	446	7	1	3	6.5	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2)c1	10.1021/acsmedchemlett.8b00149
	10292451	129460	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	4.8	CCOC(CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604048	129460	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	368	8	1	3	4.8	CCOC(CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1	10.1016/j.bmc.2015.07.028
	134131511	148936	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883627	148936	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	162664735	188865	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4781604	188865	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
	122185448	129470	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)c(F)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604058	129470	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	386	8	1	3	5.0	CCO[C@@H](CC(=O)O)c1ccc(OCc2ccc(C(F)(F)F)c(F)c2)cc1	10.1016/j.bmc.2015.07.028
	118645541	187422	0	None	4	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	526	10	1	5	7.1	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2-c2cc(C)cc(C)c2)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4754974	187422	0	None	4	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	526	10	1	5	7.1	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2-c2cc(C)cc(C)c2)c1	10.1016/j.bmcl.2018.01.013
	11961321	118576	4	None	-4	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1021/ml400501x
	CHEMBL3287569	118576	4	None	-4	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1021/ml400501x
	51350138	65623	0	None	660	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2012968
	CHEMBL1688473	65623	0	None	660	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2012968
	134131511	148936	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883627	148936	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	546	9	1	4	8.3	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/acsmedchemlett.6b00443
	145987484	171989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	413	6	1	5	5.1	Cc1noc(C)c1-c1cc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)ccc1Cl	10.1016/j.bmc.2017.12.030
	CHEMBL4228985	171989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay	ChEMBL	413	6	1	5	5.1	Cc1noc(C)c1-c1cc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)ccc1Cl	10.1016/j.bmc.2017.12.030
	155527805	178050	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	496	7	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)cc4Cl)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4460425	178050	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	496	7	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)cc4Cl)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	137635907	162727	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	527	7	1	6	5.0	COc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](F)C2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4061175	162727	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	527	7	1	6	5.0	COc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](F)C2)c1	10.1021/acs.jmedchem.7b00982
	76900387	164324	6	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	540	7	1	7	5.3	COc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	CHEMBL4080226	164324	6	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	540	7	1	7	5.3	COc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1021/acs.jmedchem.7b00982
	9957245	185764	14	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	490	22	3	5	9.0	CCCCCCCCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCCCCCCCC)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL470757	185764	14	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	490	22	3	5	9.0	CCCCCCCCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCCCCCCCC)c1O	10.1016/j.bmcl.2008.10.085
	11327107	80826	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/jm2012968
	CHEMBL2022248	80826	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/jm2012968
	162646017	186251	0	None	-5	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4740846	186251	0	None	-5	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	516	10	1	5	7.0	COc1ccc(F)c(-c2cnc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	58319134	93329	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	280	4	1	2	3.1	COc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315553	93329	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	280	4	1	2	3.1	COc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	75511304	129232	3	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	323	7	1	4	3.9	O=C(O)CCc1ccc(OCc2coc(-c3ccccc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	CHEMBL3600996	129232	3	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells by FLIPR calcium flux assay in presence of 0.1% bovine serum albumin	ChEMBL	323	7	1	4	3.9	O=C(O)CCc1ccc(OCc2coc(-c3ccccc3)n2)cc1	10.1016/j.bmcl.2015.06.018
	145990228	173685	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	436	7	1	5	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(OC(F)(F)F)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4286382	173685	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	436	7	1	5	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(OC(F)(F)F)cc3O2)cc1	10.1016/j.bmc.2018.10.019
	54584571	68943	0	None	-1	2	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777877	68943	0	None	-1	2	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	54757517	72104	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	285	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2ccc(Cl)nc2)cc1	10.1021/jm2005699
	CHEMBL1829149	72104	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	285	3	1	2	3.2	O=C(O)CCc1ccc(C#Cc2ccc(Cl)nc2)cc1	10.1021/jm2005699
	134153148	159498	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	519	7	1	6	5.5	COc1ccc(C)c(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmcl.2016.10.074
	CHEMBL3973075	159498	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assayAgonist activity at flag-tagged human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by FLIPR assay	ChEMBL	519	7	1	6	5.5	COc1ccc(C)c(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmcl.2016.10.074
	53248846	68927	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777861	68927	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	90644287	118731	0	None	2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nc2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288345	118731	0	None	2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	361	7	1	3	5.0	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)nc2)c1	10.1016/j.bmcl.2014.04.065
	131986300	170406	0	None	-2	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	528	8	1	6	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4203837	170406	0	None	-2	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	528	8	1	6	7.0	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccc(OC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	57706778	87572	29	None	-8	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	CHEMBL2152070	87572	29	None	-8	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300133f
	58218608	163463	0	None	-10	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	377	5	1	2	4.8	Cc1ccccc1Cc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4069764	163463	0	None	-10	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	377	5	1	2	4.8	Cc1ccccc1Cc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	145963330	168805	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	488	8	1	5	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4159848	168805	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	488	8	1	5	4.9	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccc4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	118129981	166246	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4101472	166246	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	68194159	189840	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4794233	189840	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
	73354950	97153	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386370	97153	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	46231548	207275	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1C	10.1016/j.bmcl.2009.10.052
	CHEMBL598673	207275	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1C	10.1016/j.bmcl.2009.10.052
	153272850	178673	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	376	7	2	4	4.4	N#Cc1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4469691	178673	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	376	7	2	4	4.4	N#Cc1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	58218651	165098	0	None	4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	5	1	3	5.0	Cc1ccccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4089171	165098	0	None	4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	5	1	3	5.0	Cc1ccccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	71612681	96782	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	406	4	1	4	5.0	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccccc2F)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381318	96782	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	406	4	1	4	5.0	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccccc2F)c1)O3	10.1016/j.bmcl.2013.03.060
	127033818	145525	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	395	6	1	5	5.0	Cc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2016.02.040
	CHEMBL3780334	145525	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	395	6	1	5	5.0	Cc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2016.02.040
	155551584	180778	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	448	8	1	4	6.0	COc1ccc(F)c(-c2ccc3c(c2)OC[C@@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4542487	180778	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	448	8	1	4	6.0	COc1ccc(F)c(-c2ccc3c(c2)OC[C@@H]3Oc2cccc([C@@H](CC(=O)O)C3CC3)c2)c1	10.1016/j.bmcl.2019.04.050
	121294455	187982	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	617	13	1	7	6.9	CCOC(CC(=O)O)c1cccc(OCC2CCN(c3cc(OC)ccc3C(=O)N(CC(C)(C)C)c3cccc(C)n3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4761155	187982	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	617	13	1	7	6.9	CCOC(CC(=O)O)c1cccc(OCC2CCN(c3cc(OC)ccc3C(=O)N(CC(C)(C)C)c3cccc(C)n3)CC2)c1	10.1021/acs.jmedchem.0c00843
	58218638	164215	0	None	75	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4078852	164215	0	None	75	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	311	5	1	3	4.2	Cc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	58218694	165250	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	327	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2C[C@@H](F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4090766	165250	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	327	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2C[C@@H](F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	25150016	192202	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	278	3	1	1	3.7	Cc1cc(C)cc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL486139	192202	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	278	3	1	1	3.7	Cc1cc(C)cc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	145971800	171278	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	424	8	1	4	4.9	CC(C)c1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4214530	171278	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	424	8	1	4	4.9	CC(C)c1ccccc1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	71655293	97136	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386354	97136	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assayAgonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	71612682	96745	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	456	4	1	4	5.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccccc2C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381280	96745	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	456	4	1	4	5.8	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccccc2C(F)(F)F)c1)O3	10.1016/j.bmcl.2013.03.060
	71612680	96781	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	440	4	1	4	5.6	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccc(F)cc2Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	CHEMBL2381317	96781	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	440	4	1	4	5.6	O=C(O)C[C@@H]1COc2cc3c(cc21)OCC(c1cccc(-c2ccc(F)cc2Cl)c1)O3	10.1016/j.bmcl.2013.03.060
	57705719	171248	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	520	10	1	3	8.4	CC[C@H](CC(=O)O)c1ccc(F)c(OCc2ccc(-c3cc(OC)ccc3F)c(C3=CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4214121	171248	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	520	10	1	3	8.4	CC[C@H](CC(=O)O)c1ccc(F)c(OCc2ccc(-c3cc(OC)ccc3F)c(C3=CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	87262743	165560	0	None	-4	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	449	6	1	4	5.6	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2OC(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4094160	165560	0	None	-4	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	449	6	1	4	5.6	O=C(O)C[C@@H]1C[C@H](C(F)(F)F)CN1c1ccc(Oc2ccccc2OC(F)(F)F)cc1	10.1021/acs.jmedchem.6b01559
	54582149	68580	0	None	33	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773255	68580	0	None	33	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	127027727	144591	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	9	1	5	6.2	O=C1NC(=O)C(Cc2ccc(OCC[C@H](Oc3ccc(C(F)(F)F)cc3)c3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759746	144591	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	501	9	1	5	6.2	O=C1NC(=O)C(Cc2ccc(OCC[C@H](Oc3ccc(C(F)(F)F)cc3)c3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	54584098	68579	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL1773254	68579	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	54757625	72112	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	270	3	1	2	3.5	Cc1ccsc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm2005699
	CHEMBL1829156	72112	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	270	3	1	2	3.5	Cc1ccsc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm2005699
	9957245	185764	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	490	22	3	5	9.0	CCCCCCCCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCCCCCCCC)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL470757	185764	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	490	22	3	5	9.0	CCCCCCCCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCCCCCCCC)c1O	10.1016/j.bmcl.2008.10.085
	168279392	197919	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assay	ChEMBL	421	9	2	3	5.6	CC1(C)C2CCC1(C)C(NCc1ccc(COc3ccc(CCC(=O)O)cc3)cc1)C2	10.1016/j.bmcl.2021.127969
	CHEMBL5188313	197919	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in calcium efflux by Fluo-8AM dye based FLIPR assay	ChEMBL	421	9	2	3	5.6	CC1(C)C2CCC1(C)C(NCc1ccc(COc3ccc(CCC(=O)O)cc3)cc1)C2	10.1016/j.bmcl.2021.127969
	142738582	191299	0	None	42	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4847662	191299	0	None	42	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assay	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	118638010	174344	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4165008	174344	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4300503	174344	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	480	7	1	5	5.7	COc1cc(-c2cnc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)c(F)cn1	10.1021/acsmedchemlett.8b00149
	3893	9067	98	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
	4642	9067	98	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
	5534	9067	98	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
	CHEMBL108766	9067	98	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
	DB03017	9067	98	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
	23346507	95063	1	None	30	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL234834	95063	1	None	30	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/ml100106c
	54584571	68943	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777877	68943	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	455	6	1	5	4.8	CC#C[C@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	57522038	10659	60	None	-1995	3	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	10659	60	None	-1995	3	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	10659	60	None	-1995	3	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	145983825	172519	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	485	12	1	7	4.7	Cc1cc(OCCO[N+](=O)[O-])cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2018.07.050
	CHEMBL4246335	172519	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	485	12	1	7	4.7	Cc1cc(OCCO[N+](=O)[O-])cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2018.07.050
	127048842	147014	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	367	6	2	5	3.8	Cc1cccc(-c2cccc(NC(=O)c3nnc(CCC(=O)O)s3)c2)c1	10.1016/j.bmc.2016.04.065
	CHEMBL3805328	147014	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium influx assayAgonist activity at human GPR40 expressed in CHO cells by calcium influx assay	ChEMBL	367	6	2	5	3.8	Cc1cccc(-c2cccc(NC(=O)c3nnc(CCC(=O)O)s3)c2)c1	10.1016/j.bmc.2016.04.065
	90644302	118747	0	None	-3	2	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	301	8	1	4	3.2	CCOC(CC(=O)O)c1ccc(OCc2ccccc2)nc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288361	118747	0	None	-3	2	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	301	8	1	4	3.2	CCOC(CC(=O)O)c1ccc(OCc2ccccc2)nc1	10.1016/j.bmcl.2014.04.065
	1622278	101779	10	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	CHEMBL254861	101779	10	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	90372616	149011	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884609	149011	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	530	10	1	4	7.6	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C(OC)C2CC2)c1	10.1021/acsmedchemlett.6b00443
	145982433	173458	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	342	8	1	4	3.8	Cc1ccc(OCCCOc2ccc3c(c2)OCC3CC(=O)O)cc1	10.1016/j.ejmech.2018.09.071
	CHEMBL4281988	173458	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	342	8	1	4	3.8	Cc1ccc(OCCCOc2ccc3c(c2)OCC3CC(=O)O)cc1	10.1016/j.ejmech.2018.09.071
	90151763	164623	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	462	6	1	6	4.3	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cccnc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	CHEMBL4083678	164623	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	462	6	1	6	4.3	C[C@@H]1C(C(F)(F)F)=NN(c2ccc(OC3CCN(c4cccnc4)CC3)cc2)[C@H]1CC(=O)O	10.1021/acs.jmedchem.7b00982
	134141490	161363	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	527	10	1	4	6.6	Cc1ccc(CC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3926143	161363	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	527	10	1	4	6.6	Cc1ccc(CC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3991349	161363	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	527	10	1	4	6.6	Cc1ccc(CC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(=O)O)cc5)cc4)CC3)C2)cc1	10.1016/j.bmc.2016.09.004
	53248846	68927	0	None	1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777861	68927	0	None	1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
	57706009	87441	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	450	8	1	3	7.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](C)CC(=O)O)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151294	87441	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	450	8	1	3	7.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@H](C)CC(=O)O)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	57391960	76799	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1021/ml300133f
	CHEMBL1939651	76799	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	370	7	1	2	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1021/ml300133f
	127025488	144615	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	403	6	1	4	5.1	Cc1ccccc1-c1cccc(COc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759922	144615	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	403	6	1	4	5.1	Cc1ccccc1-c1cccc(COc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.ejmech.2015.12.049
	142738553	169022	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	299	4	2	1	4.5	O=C(O)CCc1ccc2[nH]c(-c3ccc(Cl)cc3)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4163511	169022	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	299	4	2	1	4.5	O=C(O)CCc1ccc2[nH]c(-c3ccc(Cl)cc3)cc2c1	10.1021/acsmedchemlett.7b00460
	46231596	208752	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	401	4	1	4	5.0	O=C1NC(=O)C(Cc2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL607983	208752	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	401	4	1	4	5.0	O=C1NC(=O)C(Cc2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	90644303	118749	0	None	-2	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2cccc(C)c2)cc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288363	118749	0	None	-2	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2cccc(C)c2)cc1	10.1016/j.bmcl.2014.04.065
	137636358	162665	0	None	-1	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	517	8	1	4	6.8	COc1ccc(F)c(Cc2cccc(Oc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	CHEMBL4060499	162665	0	None	-1	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	517	8	1	4	6.8	COc1ccc(F)c(Cc2cccc(Oc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
	1622278	101779	10	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Activity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	CHEMBL254861	101779	10	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Activity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 H137F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	341	7	1	5	3.6	O=C(O)CCCCCN1C(=O)/C(=C\c2cccs2)SC1=S	10.1021/jm7012425
	45107307	118748	4	None	-3	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288362	118748	4	None	-3	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	314	8	1	3	4.1	CCOC(CC(=O)O)c1ccc(OCc2ccccc2C)cc1	10.1016/j.bmcl.2014.04.065
	71460255	87571	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL2152069	87571	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1021/acsmedchemlett.6b00443
	71460255	87571	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL2152069	87571	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	420	9	1	3	6.0	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2)c1	10.1016/j.bmcl.2019.04.050
	127047532	146427	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	427	9	1	5	5.5	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OC(C)C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3797784	146427	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	427	9	1	5	5.5	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OC(C)C)c1	10.1016/j.ejmech.2016.03.054
	1050	8683	94	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2006.12.084
	11595431	8683	94	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2006.12.084
	CHEMBL207881	8683	94	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2006.12.084
	145975484	170773	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	480	10	1	5	5.2	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4208237	170773	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	480	10	1	5	5.2	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	54757830	72125	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	335	3	1	2	4.3	O=C(O)CCc1ccc(C#Cc2ccnc3cc(Cl)ccc23)cc1	10.1021/jm2005699
	CHEMBL1829169	72125	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	335	3	1	2	4.3	O=C(O)CCc1ccc(C#Cc2ccnc3cc(Cl)ccc23)cc1	10.1021/jm2005699
	57521919	83052	0	None	-23	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058532	83052	0	None	-23	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4207911	83052	0	None	-23	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayAgonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	24825491	94806	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	305	6	2	2	4.5	O=C(O)CCc1ccc(NCc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234467	94806	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	305	6	2	2	4.5	O=C(O)CCc1ccc(NCc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2006.12.084
	24825492	156321	0	None	9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL394666	156321	0	None	9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1016/j.bmcl.2006.12.084
	54757829	72124	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	375	5	1	2	4.7	O=C(O)CCc1ccc(C#Cc2ccnc(Cl)c2Cc2ccccc2)cc1	10.1021/jm2005699
	CHEMBL1829168	72124	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	375	5	1	2	4.7	O=C(O)CCc1ccc(C#Cc2ccnc(Cl)c2Cc2ccccc2)cc1	10.1021/jm2005699
	23346507	95063	1	None	30	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1016/j.bmcl.2006.12.084
	CHEMBL234834	95063	1	None	30	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR40 receptorAgonist activity at GPR40 receptor	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1016/j.bmcl.2006.12.084
	137638995	163744	0	None	-16	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	163744	0	None	-16	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	137642604	165296	0	None	-41	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	165296	0	None	-41	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	16058685	179338	0	None	-1	2	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cellsAgonist activity at mouse GPR40 expressed in HEK293 cells	ChEMBL	229	7	1	3	3.1	CCCCCCCCC1SC(=O)NC1=O	10.1016/j.bmcl.2008.10.085
	CHEMBL448569	179338	0	None	-1	2	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cellsAgonist activity at mouse GPR40 expressed in HEK293 cells	ChEMBL	229	7	1	3	3.1	CCCCCCCCC1SC(=O)NC1=O	10.1016/j.bmcl.2008.10.085
	131986030	171593	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	566	11	2	7	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218596	171593	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	566	11	2	7	6.9	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	11674915	65636	1	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL1688486	65636	1	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b01357
	137661294	166279	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	485	7	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(N3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4101901	166279	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	485	7	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(N3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.7b01411
	68194743	189327	12	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4787498	189327	12	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
	90357481	174395	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163916	174395	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301212	174395	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	162676686	190265	0	None	-11	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL4799453	190265	0	None	-11	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
	90644296	118740	0	None	29	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	4.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(F)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288354	118740	0	None	29	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	4.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CC(F)C(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	11674915	65636	1	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688486	65636	1	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	57705880	117990	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL3264816	117990	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	57707025	171340	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	504	10	1	3	8.3	CC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4215239	171340	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	504	10	1	3	8.3	CC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	24857286	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2019.01.014
	6484	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2019.01.014
	CHEMBL1829174	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2019.01.014
	DB12491	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2019.01.014
	155512776	176443	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	462	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccccc4Cl)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4437470	176443	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	462	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccccc4Cl)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	155542122	179885	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	462	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	CHEMBL4520404	179885	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayAgonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay	ChEMBL	462	7	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccc(-c4ccc(Cl)cc4)cc3O2)cc1	10.1016/j.bmcl.2019.01.014
	145971688	169796	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	459	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCCc4ccccc43)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4175666	169796	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	459	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCCc4ccccc43)s2)cc1	10.1016/j.ejmech.2018.04.023
	24857286	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.10.019
	6484	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.10.019
	CHEMBL1829174	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.10.019
	DB12491	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2018.10.019
	90151527	163998	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	493	6	1	5	5.4	Cc1cccc(F)c1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	CHEMBL4076149	163998	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	493	6	1	5	5.4	Cc1cccc(F)c1N1CCC(Oc2ccc(N3N=C(C(F)(F)F)[C@@H](C)[C@@H]3CC(=O)O)cc2)CC1	10.1021/acs.jmedchem.7b00982
	145947468	174453	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CN(Cc4ccccc4)CC5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4244619	174453	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CN(Cc4ccccc4)CC5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	CHEMBL4301987	174453	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	8	1	4	6.4	O=C(O)C[C@@H]1COc2cc(OCc3cccc(-c4ccc5c(c4)CN(Cc4ccccc4)CC5)c3)ccc21	10.1016/j.bmcl.2018.07.048
	145948093	174505	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	9	1	3	7.2	CC(C)(CC(=O)O)c1ccc(OCc2cccc(-c3cccc4c3CCN(Cc3ccccc3)C4)c2)cc1	10.1016/j.bmcl.2018.07.048
	CHEMBL4241897	174505	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	9	1	3	7.2	CC(C)(CC(=O)O)c1ccc(OCc2cccc(-c3cccc4c3CCN(Cc3ccccc3)C4)c2)cc1	10.1016/j.bmcl.2018.07.048
	CHEMBL4302692	174505	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assayTransactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay	ChEMBL	505	9	1	3	7.2	CC(C)(CC(=O)O)c1ccc(OCc2cccc(-c3cccc4c3CCN(Cc3ccccc3)C4)c2)cc1	10.1016/j.bmcl.2018.07.048
	15659412	210729	1	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	266	4	3	5	2.5	CC(C)C(=O)c1c(O)cc(O)c(C(=O)C(C)C)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL6931	210729	1	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	266	4	3	5	2.5	CC(C)C(=O)c1c(O)cc(O)c(C(=O)C(C)C)c1O	10.1016/j.bmcl.2008.10.085
	145990337	173559	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	390	6	1	5	3.3	O=C(O)CC1(c2ccc(OCC3COc4ccc(Cl)cc4O3)cc2)COC1	10.1016/j.bmc.2018.10.019
	CHEMBL4283988	173559	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	390	6	1	5	3.3	O=C(O)CC1(c2ccc(OCC3COc4ccc(Cl)cc4O3)cc2)COC1	10.1016/j.bmc.2018.10.019
	145986689	173988	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	376	4	1	2	5.3	Cc1ccc(-c2cccc(COc3ccc(C#CC(=O)O)cc3)c2)c(Cl)c1	10.1016/j.ejmech.2018.08.075
	CHEMBL4291766	173988	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by calcium-5 dye based assay	ChEMBL	376	4	1	2	5.3	Cc1ccc(-c2cccc(COc3ccc(C#CC(=O)O)cc3)c2)c(Cl)c1	10.1016/j.ejmech.2018.08.075
	137634330	163154	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	540	12	1	6	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	CHEMBL4066238	163154	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	540	12	1	6	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3c(C)cc(OCCCS(C)(=O)=O)cc3C)c2)s1	10.1021/acs.jmedchem.6b01357
	90644294	118738	0	None	13	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(C)n2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288352	118738	0	None	13	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(C)n2)c1	10.1016/j.bmcl.2014.04.065
	66562287	145956	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	232	3	1	1	2.8	C=C(C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787463	145956	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	232	3	1	1	2.8	C=C(C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	51350272	65615	0	None	107	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albumin	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	CHEMBL1688465	65615	0	None	107	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albuminAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay in presence of 0.05 % bovine serum albumin	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
	134133343	161254	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	531	10	1	4	6.4	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccccc3F)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3898066	161254	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	531	10	1	4	6.4	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccccc3F)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	CHEMBL3990349	161254	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as induction of Ca2+ flux by fluo-8 dye based FLIPR assay	ChEMBL	531	10	1	4	6.4	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Cc3ccccc3F)CCO4)cc2)cc1	10.1016/j.bmc.2016.09.004
	118144982	177131	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2F)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4447353	177131	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	478	8	1	3	6.9	COc1ccc(F)c(-c2ccc3c(c2F)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	73777175	150687	0	None	-17	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	150687	0	None	-17	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	71562640	93297	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	386	8	1	4	2.9	CS(=O)(=O)CCCOc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315253	93297	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	386	8	1	4	2.9	CS(=O)(=O)CCCOc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm301470a
	15659412	210729	1	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	266	4	3	5	2.5	CC(C)C(=O)c1c(O)cc(O)c(C(=O)C(C)C)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL6931	210729	1	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	266	4	3	5	2.5	CC(C)C(=O)c1c(O)cc(O)c(C(=O)C(C)C)c1O	10.1016/j.bmcl.2008.10.085
	90372458	149002	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	500	7	1	3	7.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc(CCC(=O)O)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3884347	149002	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	500	7	1	3	7.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc(CCC(=O)O)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	51350273	65632	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.0	COc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	CHEMBL1688482	65632	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	362	8	1	3	5.0	COc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm101405t
	137644843	164938	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	423	6	1	5	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(CC3SC(=O)NC3=O)s2)c1	10.1021/acs.jmedchem.6b01357
	CHEMBL4087365	164938	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay	ChEMBL	423	6	1	5	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc(CC3SC(=O)NC3=O)s2)c1	10.1021/acs.jmedchem.6b01357
	58173000	125906	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	326	7	1	3	3.8	CCO[C@@H](CC(=O)O)c1ccc(OC2Cc3ccccc3C2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3427707	125906	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	326	7	1	3	3.8	CCO[C@@H](CC(=O)O)c1ccc(OC2Cc3ccccc3C2)cc1	10.1016/j.bmc.2015.07.028
	58218673	164304	0	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	413	5	1	3	5.7	Cc1c(Cl)cccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4079930	164304	0	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	413	5	1	3	5.7	Cc1c(Cl)cccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	58218726	165917	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(C)c1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4097951	165917	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	5	1	3	5.3	Cc1cccc(C)c1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
	71613093	96761	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381297	96761	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	570	9	1	7	5.4	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc([C@@H]2COc3cc4c(cc3O2)OC[C@H]4CC(=O)O)c1	10.1016/j.bmcl.2013.03.060
	145951402	169620	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	494	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(C4CCCCC4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4172853	169620	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	494	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(C4CCCCC4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	4987566	101434	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	333	7	2	3	4.6	O=C(O)c1cccc(NCc2cccc(OCc3ccccc3)c2)c1	10.1021/jm7012425
	CHEMBL252527	101434	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayAgonist activity at FFAR1 expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	333	7	2	3	4.6	O=C(O)c1cccc(NCc2cccc(OCc3ccccc3)c2)c1	10.1021/jm7012425
	137638317	163501	0	None	-11	2	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070273	163501	0	None	-11	2	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
	131986250	170464	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	471	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4204776	170464	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	471	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	58173000	125906	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	326	7	1	3	3.8	CCO[C@@H](CC(=O)O)c1ccc(OC2Cc3ccccc3C2)cc1	10.1021/ml500391n
	CHEMBL3427707	125906	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay	ChEMBL	326	7	1	3	3.8	CCO[C@@H](CC(=O)O)c1ccc(OC2Cc3ccccc3C2)cc1	10.1021/ml500391n
	162675949	190077	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	614	12	1	7	6.8	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cc([C@H](CC(=O)O)C4CC4)ccn3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4797024	190077	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	614	12	1	7	6.8	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cc([C@H](CC(=O)O)C4CC4)ccn3)CC2)c1	10.1021/acs.jmedchem.0c00843
	54583098	68583	0	None	70	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1773258	68583	0	None	70	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	58319094	93324	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	328	3	1	1	3.9	O=C(O)CCc1ccc(C#Cc2ccccc2Br)cc1	10.1021/jm301470a
	CHEMBL2315548	93324	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	328	3	1	1	3.9	O=C(O)CCc1ccc(C#Cc2ccccc2Br)cc1	10.1021/jm301470a
	127031001	145911	0	None	91	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786972	145911	0	None	91	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	54586011	68582	0	None	14	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/ml100106c
	CHEMBL1773257	68582	0	None	14	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/ml100106c
	145981771	173447	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	366	6	1	4	3.7	O=C(O)CCc1ccc(OCC2COc3ccc(Cl)cc3O2)cc1F	10.1016/j.bmc.2018.10.019
	CHEMBL4281714	173447	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	366	6	1	4	3.7	O=C(O)CCc1ccc(OCC2COc3ccc(Cl)cc3O2)cc1F	10.1016/j.bmc.2018.10.019
	561372	65601	65	None	20	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/ml100106c
	CHEMBL1688452	65601	65	None	20	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/ml100106c
	90372625	174500	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4159022	174500	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4302640	174500	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	444	7	1	5	5.4	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)nc2)ccn1	10.1021/acsmedchemlett.8b00149
	57325841	80880	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	474	11	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022579	80880	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	474	11	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	121294461	189210	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	615	11	1	7	6.1	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cccc(C4(CC(=O)O)COC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4786019	189210	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	615	11	1	7	6.1	COc1ccc(C(=O)N(CC(C)(C)C)c2cccc(C)n2)c(N2CCC(COc3cccc(C4(CC(=O)O)COC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	90644288	118732	0	None	-20	2	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288346	118732	0	None	-20	2	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	366	7	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)s2)c1	10.1016/j.bmcl.2014.04.065
	145994196	174174	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	354	9	1	4	3.8	O=C(O)COc1ccc(OCCCOc2cccc(Cl)c2)cc1F	10.1016/j.ejmech.2018.09.071
	CHEMBL4295200	174174	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay	ChEMBL	354	9	1	4	3.8	O=C(O)COc1ccc(OCCCOc2cccc(Cl)c2)cc1F	10.1016/j.ejmech.2018.09.071
	131986182	171400	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cc(OCCOC)ccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4216026	171400	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cc(OCCOC)ccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	54582628	68929	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	4.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Br)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777863	68929	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	4.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Br)cc1	10.1016/j.bmcl.2011.03.114
	44589697	198390	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	354	7	1	1	5.5	C=C/C=C/c1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1/C=C/C=C	10.1021/jm8010178
	CHEMBL519548	198390	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	354	7	1	1	5.5	C=C/C=C/c1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1/C=C/C=C	10.1021/jm8010178
	127033821	145594	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	415	6	1	5	5.3	Cc1nc(-c2ccc(Cl)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	CHEMBL3781162	145594	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	415	6	1	5	5.3	Cc1nc(-c2ccc(Cl)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	57521812	83042	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL2058523	83042	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	127027728	144614	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	467	9	1	5	5.8	O=C1NC(=O)C(Cc2ccc(OCC[C@H](Oc3ccc(Cl)cc3)c3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759913	144614	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	467	9	1	5	5.8	O=C1NC(=O)C(Cc2ccc(OCC[C@H](Oc3ccc(Cl)cc3)c3ccccc3)cc2)S1	10.1016/j.ejmech.2015.12.049
	137642604	165296	0	None	-41	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	165296	0	None	-41	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	131986162	171615	0	None	-3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	414	7	1	5	5.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4218822	171615	0	None	-3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	414	7	1	5	5.2	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	58230598	189898	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
	CHEMBL4794904	189898	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
	148173135	177930	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	393	8	2	3	5.7	CC(C)c1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	CHEMBL4458669	177930	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assayAgonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay	ChEMBL	393	8	2	3	5.7	CC(C)c1ccccc1-c1cccc(CNc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2019.06.087
	137638995	163744	0	None	-16	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	163744	0	None	-16	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	127046667	146715	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)ccn1	10.1016/j.ejmech.2016.03.054
	CHEMBL3799646	146715	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	370	7	1	5	4.1	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)ccn1	10.1016/j.ejmech.2016.03.054
	155565379	182345	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c(F)cn1	10.1016/j.bmcl.2019.04.050
	CHEMBL4579146	182345	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1cc(-c2ccc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c(F)cn1	10.1016/j.bmcl.2019.04.050
	25150015	192083	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	278	3	1	1	3.7	Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm8010178
	CHEMBL485935	192083	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	278	3	1	1	3.7	Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm8010178
	3367	7939	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/jm2005699
	46216676	7939	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/jm2005699
	CHEMBL604126	7939	1	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/jm2005699
	1050	8683	94	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/ml100106c
	11595431	8683	94	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/ml100106c
	CHEMBL207881	8683	94	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assayAgonist activity at human FFA1 transfected in 1321N1 cells under serum-free condition after 1 hr by dose response curve/dynamic mass redistribution optical biosensor assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/ml100106c
	168291052	198698	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	472	10	1	4	6.4	Cc1ccc(OCc2ccccc2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5200197	198698	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	472	10	1	4	6.4	Cc1ccc(OCc2ccccc2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	54580626	68940	0	None	3	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777874	68940	0	None	3	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
	131986065	170632	0	None	-4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	465	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206579	170632	0	None	-4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	465	7	1	6	5.7	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	46231841	208907	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	435	4	1	4	5.7	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2C(F)(F)F)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL609037	208907	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	435	4	1	4	5.7	O=C1NC(=O)C(Cc2ccc(Oc3ccc(Cl)cc3Cl)cc2C(F)(F)F)S1	10.1016/j.bmcl.2009.10.052
	71615670	96779	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1ccc(C)c(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381315	96779	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	416	4	1	4	5.4	Cc1ccc(C)c(-c2cccc(C3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c1	10.1016/j.bmcl.2013.03.060
	54582628	68929	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	4.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Br)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777863	68929	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	4.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Br)cc1	10.1016/j.bmcl.2011.03.114
	168289402	198090	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	408	7	1	4	5.8	O=C(O)COc1ccc(OCc2cccc(-c3ccc4ccsc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	CHEMBL5191306	198090	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	408	7	1	4	5.8	O=C(O)COc1ccc(OCc2cccc(-c3ccc4ccsc4c3)c2)cc1F	10.1016/j.bmc.2022.116615
	137647107	164332	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	CHEMBL4080336	164332	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
	10266133	162947	5	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Antagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assayAntagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay	ChEMBL	288	4	2	0	5.6	CCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1021/acs.jmedchem.6b01593
	CHEMBL4063898	162947	5	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Antagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assayAntagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay	ChEMBL	288	4	2	0	5.6	CCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1021/acs.jmedchem.6b01593
	11507535	166077	1	None	-1	2	Human	5.1	pEC50	=	5.1	Functional	Antagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assayAntagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay	ChEMBL	288	3	2	0	5.4	CC(C)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1021/acs.jmedchem.6b01593
	CHEMBL4099626	166077	1	None	-1	2	Human	5.1	pEC50	=	5.1	Functional	Antagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assayAntagonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as inhibition of TUG-424-induced intracellular calcium level preincubated for 30 mins followed by TUG-424 addition measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay	ChEMBL	288	3	2	0	5.4	CC(C)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1021/acs.jmedchem.6b01593
	58172991	129454	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	330	9	1	4	3.8	CCOC(CC(=O)O)c1ccc(OCc2cccc(OC)c2)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604042	129454	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	330	9	1	4	3.8	CCOC(CC(=O)O)c1ccc(OCc2cccc(OC)c2)cc1	10.1016/j.bmc.2015.07.028
	146316684	178344	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	CHEMBL4464769	178344	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayAgonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
	58319135	93321	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	278	4	1	1	3.7	CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315545	93321	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	278	4	1	1	3.7	CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	25150013	193026	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	318	3	1	1	4.1	O=C(O)CCc1ccc(C#Cc2cccc(C(F)(F)F)c2)cc1	10.1021/jm8010178
	CHEMBL487365	193026	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	318	3	1	1	4.1	O=C(O)CCc1ccc(C#Cc2cccc(C(F)(F)F)c2)cc1	10.1021/jm8010178
	54584098	68579	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/ml100106c
	CHEMBL1773254	68579	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/ml100106c
	127047533	146684	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	441	11	1	5	5.9	CCCCOc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3799443	146684	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	441	11	1	5	5.9	CCCCOc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	137658391	166427	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	6	1	3	5.3	Cc1cc(OCc2ccc(Cl)cc2Cl)ccc1N1CCC[C@H]1CC(=O)O	10.1021/acs.jmedchem.6b01559
	CHEMBL4103681	166427	0	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	393	6	1	3	5.3	Cc1cc(OCc2ccc(Cl)cc2Cl)ccc1N1CCC[C@H]1CC(=O)O	10.1021/acs.jmedchem.6b01559
	25150117	193466	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	280	4	2	2	2.6	O=C(O)CCc1ccc(C#Cc2cccc(CO)c2)cc1	10.1021/jm8010178
	CHEMBL488385	193466	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	280	4	2	2	2.6	O=C(O)CCc1ccc(C#Cc2cccc(CO)c2)cc1	10.1021/jm8010178
	118645756	188241	7	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulationAgonist activity at human GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulation	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	CHEMBL4764485	188241	7	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulationAgonist activity at human GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulation	ChEMBL	479	11	1	6	5.4	COc1cc(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2CC(C)C)c(F)cn1	10.1016/j.bmcl.2018.01.013
	131986295	170321	0	None	-2	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4202907	170321	0	None	-2	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	538	11	1	7	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCOC)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	131986294	170620	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	464	7	1	5	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206445	170620	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	464	7	1	5	6.3	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	90644562	118583	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2cnco2)cc1	10.1021/ml400501x
	CHEMBL3287576	118583	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayAgonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2cnco2)cc1	10.1021/ml400501x
	118129979	162573	0	None	3	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL4059614	162573	0	None	3	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
	131986116	170603	0	None	1	2	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	600	12	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	CHEMBL4206318	170603	0	None	1	2	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayAgonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay	ChEMBL	600	12	1	8	6.1	CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1	10.1016/j.bmcl.2017.12.022
	51049992	152397	5	None	-23	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.7b01411
	CHEMBL3915620	152397	5	None	-23	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assayAgonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.7b01411
	51049992	152397	5	None	-23	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	CHEMBL3915620	152397	5	None	-23	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assayAgonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
	60195125	10660	8	None	4	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	10660	8	None	4	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	10660	8	None	4	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	44409926	82758	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	485	7	2	4	6.5	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC2CCC2)cc1	10.1016/j.bmcl.2006.01.007
	CHEMBL205433	82758	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist potency at human GPR40 expressed in CHO cellsAgonist potency at human GPR40 expressed in CHO cells	ChEMBL	485	7	2	4	6.5	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc([C@H]2C[C@@H]2C(=O)NC2CCC2)cc1	10.1016/j.bmcl.2006.01.007
	127045863	146758	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	403	7	1	4	5.3	Cc1noc(C)c1-c1ccc(Cl)c(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3799898	146758	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	403	7	1	4	5.3	Cc1noc(C)c1-c1ccc(Cl)c(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1016/j.ejmech.2016.03.054
	90644293	118737	0	None	13	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ncc1CCC(=O)O	10.1016/j.bmcl.2014.04.065
	CHEMBL3288351	118737	0	None	13	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(OCc2cccc(-c3c(C)cccc3C)c2)ncc1CCC(=O)O	10.1016/j.bmcl.2014.04.065
	60195038	88567	0	None	912	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164239	88567	0	None	912	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilizationAgonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	142738539	169098	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	343	4	2	1	4.6	O=C(O)CCc1ccc2[nH]c(-c3ccccc3Br)cc2c1	10.1021/acsmedchemlett.7b00460
	CHEMBL4164625	169098	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assayAgonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay	ChEMBL	343	4	2	1	4.6	O=C(O)CCc1ccc2[nH]c(-c3ccccc3Br)cc2c1	10.1021/acsmedchemlett.7b00460
	118645671	187708	0	None	5	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	476	10	1	5	6.3	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C=C(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4758060	187708	0	None	5	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	476	10	1	5	6.3	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C=C(C)C)c1	10.1016/j.bmcl.2018.01.013
	162659599	187977	0	None	4	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4761101	187977	0	None	4	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	515	10	1	4	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2C2=CCCC2(C)C)c1	10.1016/j.bmcl.2018.01.013
	118645392	186888	0	None	2	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	494	12	1	6	5.9	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2OCC(C)C)c1	10.1016/j.bmcl.2018.01.013
	CHEMBL4748392	186888	0	None	2	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysisAgonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based fluorescence analysis	ChEMBL	494	12	1	6	5.9	COc1ccc(F)c(-c2ncc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)nc2OCC(C)C)c1	10.1016/j.bmcl.2018.01.013
	51350407	65638	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1ccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm101405t
	CHEMBL1688488	65638	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSAAgonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL	360	7	1	2	5.6	Cc1ccc(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm101405t
	45107323	129477	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	410	8	1	4	5.2	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(OC(F)(F)F)cccc32)cc1	10.1016/j.bmc.2015.07.028
	CHEMBL3604065	129477	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	410	8	1	4	5.2	CCO[C@@H](CC(=O)O)c1ccc(O[C@@H]2CCc3c(OC(F)(F)F)cccc32)cc1	10.1016/j.bmc.2015.07.028
	57705679	170288	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	522	10	1	3	8.5	CC[C@H](CC(=O)O)c1cc(F)cc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4202429	170288	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	522	10	1	3	8.5	CC[C@H](CC(=O)O)c1cc(F)cc(OCc2ccc(-c3cc(OC)ccc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/acsmedchemlett.8b00213
	57706280	171606	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	530	10	1	3	8.7	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	CHEMBL4218710	171606	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assayAgonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aequorin based luminescence assay	ChEMBL	530	10	1	3	8.7	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CCC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.8b00213
	46231778	206260	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	4.1	O=C1NC(=O)C(Cc2ccc(Oc3ncc(Cl)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL591686	206260	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	368	4	1	5	4.1	O=C1NC(=O)C(Cc2ccc(Oc3ncc(Cl)cc3Cl)cc2)S1	10.1016/j.bmcl.2009.10.052
	145992623	173637	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	352	6	1	4	3.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmc.2018.10.019
	CHEMBL4285582	173637	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	352	6	1	4	3.5	CC#C[C@@H](CC(=O)O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmc.2018.10.019
	134130352	148923	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883532	148923	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	540	8	1	3	8.7	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@@H](CC(=O)O)C5CC5)cc4O3)cc2C2=CCCC2(C)C)c1	10.1021/acsmedchemlett.6b00443
	118145020	177848	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cnc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	CHEMBL4457184	177848	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting methodPositive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method	ChEMBL	461	8	1	4	6.2	COc1ccc(F)c(-c2cnc3c(c2)CC[C@H]3Oc2cccc([C@H](C3CC3)[C@H](C)C(=O)O)c2)c1	10.1016/j.bmcl.2019.04.050
	127046663	146553	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	439	10	1	5	5.5	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OCC2CC2)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798609	146553	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	439	10	1	5	5.5	Cc1noc(C)c1-c1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(OCC2CC2)c1	10.1016/j.ejmech.2016.03.054
	57705863	87440	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	436	8	1	3	6.4	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	CHEMBL2151293	87440	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumAgonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL	436	8	1	3	6.4	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2C(C)(C)C)c1	10.1021/ml300133f
	57391957	76787	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	312	8	1	3	4.0	C=CC(CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	CHEMBL1939639	76787	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayAgonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay	ChEMBL	312	8	1	3	4.0	C=CC(CC(=O)O)c1ccc(OCc2ccc(OC)cc2)cc1	10.1016/j.bmcl.2011.10.118
	137640781	163796	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	516	10	1	6	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Oc3ccccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	CHEMBL4073421	163796	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay	ChEMBL	516	10	1	6	5.3	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(Oc3ccccn3)CCO4)cc2)cc1	10.1016/j.ejmech.2017.01.005
	57325917	80883	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	476	11	1	5	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)COC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022582	80883	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	476	11	1	5	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)COC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
	54586011	68582	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773257	68582	0	None	14	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	25150012	200231	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	275	3	1	2	3.0	N#Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	CHEMBL526510	200231	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	275	3	1	2	3.0	N#Cc1cccc(C#Cc2ccc(CCC(=O)O)cc2)c1	10.1021/jm8010178
	168274068	197065	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	478	10	1	4	6.8	Cc1ccc(OCC2CCCCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	CHEMBL5175750	197065	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in calcium level measured by Fluo-4-AM staining based FLIPR assay	ChEMBL	478	10	1	4	6.8	Cc1ccc(OCC2CCCCC2)cc1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2022.116615
	90644295	118739	0	None	-3	2	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(CCC(=O)O)cnc1OCc1cccc(-c2c(C)cccc2C)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288353	118739	0	None	-3	2	Rat	5.0	pEC50	=	5.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	375	7	1	3	5.3	Cc1cc(CCC(=O)O)cnc1OCc1cccc(-c2c(C)cccc2C)c1	10.1016/j.bmcl.2014.04.065
	51349860	65602	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1021/ml100106c
	CHEMBL1688453	65602	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assayAgonist activity at human FFA1 transfected in 1321N1 cells assessed as calcium mobilization by microplate assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1	10.1021/ml100106c
	54757619	72107	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	286	3	1	3	2.5	O=C(O)CCc1ccc(C#Cc2ccnc(Cl)n2)cc1	10.1021/jm2005699
	CHEMBL1829151	72107	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	286	3	1	3	2.5	O=C(O)CCc1ccc(C#Cc2ccnc(Cl)n2)cc1	10.1021/jm2005699
	118642379	148897	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	CHEMBL3883354	148897	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	460	7	1	3	6.8	COc1ccc(F)c(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@@H](C)C(=O)O)cc4O3)cc2)c1	10.1021/acsmedchemlett.6b00443
	118719720	122441	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	532	12	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(Cl)c2)c1	10.1016/j.bmc.2014.11.016
	CHEMBL3353741	122441	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assayAgonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay	ChEMBL	532	12	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(Cl)c2)c1	10.1016/j.bmc.2014.11.016
	90357481	174395	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163916	174395	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	CHEMBL4301212	174395	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of 100% human serum by HTRF assay	ChEMBL	461	7	1	4	6.2	COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1	10.1021/acsmedchemlett.8b00149
	137646368	164807	0	None	-3	2	Mouse	5.0	pEC50	=	5.0	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4085695	164807	0	None	-3	2	Mouse	5.0	pEC50	=	5.0	Functional	Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assayAgonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	134133297	150557	0	None	-117	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	150557	0	None	-117	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	46231434	207384	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	297	4	1	3	3.2	O=C1NC(=O)C(Cc2ccc(Cc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	CHEMBL599270	207384	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	297	4	1	3	3.2	O=C1NC(=O)C(Cc2ccc(Cc3ccccc3)cc2)S1	10.1016/j.bmcl.2009.10.052
	54582629	68930	0	None	-1	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777864	68930	0	None	-1	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
	71562421	93315	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	Cc1cccc(C#Cc2ccc([C@H]3C[C@@H]3C(=O)O)cc2)c1	10.1021/jm301470a
	CHEMBL2315539	93315	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	276	2	1	1	3.6	Cc1cccc(C#Cc2ccc([C@H]3C[C@@H]3C(=O)O)cc2)c1	10.1021/jm301470a
	145985123	172688	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	513	14	1	7	5.5	Cc1cc(OCCCCO[N+](=O)[O-])cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2018.07.050
	CHEMBL4250135	172688	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	513	14	1	7	5.5	Cc1cc(OCCCCO[N+](=O)[O-])cc(C)c1-c1cccc(COc2ccc(OCC(=O)O)c(F)c2)c1	10.1016/j.bmc.2018.07.050
	57521810	83040	0	None	-1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058521	83040	0	None	-1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	11265145	93309	1	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	248	2	1	1	3.2	O=C(O)/C=C/c1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	CHEMBL2315533	93309	1	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	248	2	1	1	3.2	O=C(O)/C=C/c1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	145957539	169020	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	482	7	1	3	7.3	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(OC(F)(F)F)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	CHEMBL4163496	169020	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay	ChEMBL	482	7	1	3	7.3	O=C(O)C[C@H](c1ccc2c(c1)OC(c1ccc(-c3cccc(OC(F)(F)F)c3)cc1)CC2)C1CC1	10.1021/acsmedchemlett.8b00149
	54580624	68926	0	None	2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	362	5	1	2	5.4	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2C)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777860	68926	0	None	2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	362	5	1	2	5.4	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2C)cc1	10.1016/j.bmcl.2011.03.114
	145954367	169344	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	533	9	1	7	4.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4168467	169344	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	533	9	1	7	4.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	71613095	96763	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	558	9	1	7	5.3	CS(=O)(=O)CCCOc1ccc(-c2cccc([C@@H]3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	CHEMBL2381299	96763	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 transfected in CHO cells by calcium flux assayAgonist activity at human GPR40 transfected in CHO cells by calcium flux assay	ChEMBL	558	9	1	7	5.3	CS(=O)(=O)CCCOc1ccc(-c2cccc([C@@H]3COc4cc5c(cc4O3)OC[C@H]5CC(=O)O)c2)c(Cl)c1	10.1016/j.bmcl.2013.03.060
	75204485	162775	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	496	8	1	5	5.0	COc1ccc(F)c(N2CC[C@H](COc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C2)c1	10.1021/acs.jmedchem.7b00982
	CHEMBL4061819	162775	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assay	ChEMBL	496	8	1	5	5.0	COc1ccc(F)c(N2CC[C@H](COc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C2)c1	10.1021/acs.jmedchem.7b00982
	23111754	80823	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/jm2012968
	CHEMBL2022245	80823	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/jm2012968
	134144214	157137	0	None	-354	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	157137	0	None	-354	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human GPR40 measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR40 measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	54582630	68932	0	None	1	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777866	68932	0	None	1	2	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
	71562637	93331	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	334	4	1	2	4.0	O=C(O)CCc1ccc(C#Cc2cccc(OC(F)(F)F)c2)cc1	10.1021/jm301470a
	CHEMBL2315555	93331	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	334	4	1	2	4.0	O=C(O)CCc1ccc(C#Cc2cccc(OC(F)(F)F)c2)cc1	10.1021/jm301470a
	25149901	193465	1	None	61	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm8010178
	CHEMBL488384	193465	1	None	61	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm8010178
	145974719	171475	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	482	10	1	5	5.4	Cc1cc(OCC(C)C)cc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	CHEMBL4217180	171475	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	482	10	1	5	5.4	Cc1cc(OCC(C)C)cc(C)c1-c1cccc(COc2ccc(S(=O)(=O)CC(=O)O)cc2)c1	10.1016/j.ejmech.2017.07.001
	54585512	68937	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	335	5	1	4	3.0	CC#CC(c1ccc(OCc2ccccc2)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777871	68937	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	335	5	1	4	3.0	CC#CC(c1ccc(OCc2ccccc2)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
	57521919	83052	0	None	-23	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058532	83052	0	None	-23	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4207911	83052	0	None	-23	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	54757620	72108	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	282	4	1	4	1.9	COc1nccc(C#Cc2ccc(CCC(=O)O)cc2)n1	10.1021/jm2005699
	CHEMBL1829152	72108	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryAgonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry	ChEMBL	282	4	1	4	1.9	COc1nccc(C#Cc2ccc(CCC(=O)O)cc2)n1	10.1021/jm2005699
	25149901	193465	1	None	61	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm8010178
	CHEMBL488384	193465	1	None	61	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assayAgonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/jm8010178
	46231488	206121	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1cc(C)cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	CHEMBL590699	206121	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAAgonist activity at human GPR40 by FLIPR assay in presence of 1% BSA	ChEMBL	327	4	1	4	4.0	Cc1cc(C)cc(Oc2ccc(CC3SC(=O)NC3=O)cc2)c1	10.1016/j.bmcl.2009.10.052
	90644299	118743	0	None	-5	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc(C(F)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	CHEMBL3288357	118743	0	None	-5	2	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	379	7	1	3	5.4	Cc1cccc(C)c1-c1cccc(COc2ccc(C(F)CC(=O)O)cn2)c1	10.1016/j.bmcl.2014.04.065
	127029850	145516	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	CHEMBL3780211	145516	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as Ca2+ influx by FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2016.02.040
	127047531	146499	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	427	10	1	5	5.5	CCCOc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	CHEMBL3798213	146499	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assayAgonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay	ChEMBL	427	10	1	5	5.5	CCCOc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)noc2C)c1	10.1016/j.ejmech.2016.03.054
	57325840	80879	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	460	10	1	4	5.8	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CC(C(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	CHEMBL2022578	80879	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSAAgonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR assay in presence of 0.1% BSA	ChEMBL	460	10	1	4	5.8	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CC(C(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
	58218655	162944	0	None	2	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	341	6	1	4	3.9	CO[C@H]1C[C@@H](CC(=O)O)N(c2ccc(Oc3ccccc3C)cc2)C1	10.1021/acs.jmedchem.6b01559
	CHEMBL4063889	162944	0	None	2	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assay	ChEMBL	341	6	1	4	3.9	CO[C@H]1C[C@@H](CC(=O)O)N(c2ccc(Oc3ccccc3C)cc2)C1	10.1021/acs.jmedchem.6b01559
	145957072	169053	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4cccc(F)c4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	CHEMBL4163958	169053	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayAgonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assay	ChEMBL	506	8	1	5	5.0	CC#CC(CC(=O)O)c1ccc(OCc2ccc(C(=O)N3CCN(c4cccc(F)c4)CC3)s2)cc1	10.1016/j.ejmech.2018.04.023
	24825509	94721	0	None	29	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234057	94721	0	None	29	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	145967558	171611	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	398	8	1	5	3.9	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.ejmech.2017.07.001
	CHEMBL4218763	171611	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo 4AM dye-based FLIPR assay	ChEMBL	398	8	1	5	3.9	O=C(O)CS(=O)(=O)c1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.ejmech.2017.07.001
	853224	101350	11	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Activity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	CHEMBL251963	101350	11	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Activity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assayActivity at FFAR1 L186F mutant expressed in HEK-EM293 cells assessed as calcium influx by FLIPR assay	ChEMBL	348	6	1	6	4.2	O=C(O)CSc1nnc(SCc2cccc3ccccc23)s1	10.1021/jm7012425
	58172984	129450	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	398	9	1	4	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1OC	10.1016/j.bmc.2015.07.028
	CHEMBL3604039	129450	2	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	398	9	1	4	5.1	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1OC	10.1016/j.bmc.2015.07.028
	54581632	68924	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	388	6	2	3	4.5	O=C(O)C(Cc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1)C(=O)O	10.1016/j.bmcl.2011.03.114
	CHEMBL1777858	68924	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	388	6	2	3	4.5	O=C(O)C(Cc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1)C(=O)O	10.1016/j.bmcl.2011.03.114
	146314522	187499	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	495	12	2	5	5.7	COc1ccc(CCC(C)(C)O)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	CHEMBL4755717	187499	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayAgonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay	ChEMBL	495	12	2	5	5.7	COc1ccc(CCC(C)(C)O)c(N2CCC(COc3cccc(C(CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acs.jmedchem.0c00843
	44571477	190721	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	350	9	3	5	4.6	CCCCc1c(O)c(C(=O)CC(C)C)c(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL481542	190721	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	350	9	3	5	4.6	CCCCc1c(O)c(C(=O)CC(C)C)c(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	70522117	93332	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	236	2	1	1	2.7	O=C(O)Cc1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	CHEMBL2315556	93332	1	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysisAgonist activity at human FFA1 assessed as calcium mobilization measured for 50 intervals of 0.4 secs by microplate reader analysis	ChEMBL	236	2	1	1	2.7	O=C(O)Cc1ccc(C#Cc2ccccc2)cc1	10.1021/jm301470a
	44571477	190721	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	350	9	3	5	4.6	CCCCc1c(O)c(C(=O)CC(C)C)c(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	CHEMBL481542	190721	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayAgonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay	ChEMBL	350	9	3	5	4.6	CCCCc1c(O)c(C(=O)CC(C)C)c(O)c(C(=O)CC(C)C)c1O	10.1016/j.bmcl.2008.10.085
	25098573	9523	8	None	-8	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	5587	9523	8	None	-8	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	CHEMBL463785	9523	8	None	-8	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assayAgonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	58172978	129449	2	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	402	8	1	3	5.8	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1Cl	10.1016/j.bmc.2015.07.028
	CHEMBL3604038	129449	2	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assayAgonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level after 60 mins by FLIPR assay	ChEMBL	402	8	1	3	5.8	CCOC(CC(=O)O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1Cl	10.1016/j.bmc.2015.07.028
	145982071	173255	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	410	6	1	4	3.8	O=C(O)CCc1ccc(OCC2COc3cc(Br)ccc3O2)cc1F	10.1016/j.bmc.2018.10.019
	CHEMBL4278249	173255	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assayAgonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay	ChEMBL	410	6	1	4	3.8	O=C(O)CCc1ccc(OCC2COc3cc(Br)ccc3O2)cc1F	10.1016/j.bmc.2018.10.019
	54583581	68934	0	None	2	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	307	5	1	5	2.7	CC#CC(CC(=O)O)c1ccc(Oc2nccnc2C#N)cc1	10.1016/j.bmcl.2011.03.114
	CHEMBL1777868	68934	0	None	2	2	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	307	5	1	5	2.7	CC#CC(CC(=O)O)c1ccc(Oc2nccnc2C#N)cc1	10.1016/j.bmcl.2011.03.114
	12002185	82608	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	513	12	2	5	5.6	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	CHEMBL2048625	82608	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSAAgonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the presence of 0.1% BSA	ChEMBL	513	12	2	5	5.6	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
	1050	8683	94	None	1	3	Rat	7.0	pEC50	=	7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.04.065
	11595431	8683	94	None	1	3	Rat	7.0	pEC50	=	7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.04.065
	CHEMBL207881	8683	94	None	1	3	Rat	7.0	pEC50	=	7	Functional	Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assayAgonist activity at rat GPR40 expressed in CHO cells by calcium flux assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.04.065
	85970906	144556	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	389	6	1	4	4.8	O=C1NC(=O)C(Cc2ccc(OCc3cccc(-c4ccccc4)c3)cc2)S1	10.1016/j.ejmech.2015.12.049
	CHEMBL3759467	144556	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	ChEMBL	389	6	1	4	4.8	O=C1NC(=O)C(Cc2ccc(OCc3cccc(-c4ccccc4)c3)cc2)S1	10.1016/j.ejmech.2015.12.049
	44591693	191014	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	419	6	1	2	5.8	CCC(CC)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.03.082
	CHEMBL483546	191014	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	419	6	1	2	5.8	CCC(CC)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.03.082
	44591612	191303	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	421	6	1	3	5.4	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(O[C@H]2CC[C@@H](C)CC2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL484771	191303	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	421	6	1	3	5.4	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(O[C@H]2CC[C@@H](C)CC2)cc1	10.1016/j.bmcl.2009.03.082
	44591719	191557	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	408	6	1	4	5.1	CCC(CC)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1nc2ccccc2s1	10.1016/j.bmcl.2009.03.082
	CHEMBL485131	191557	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	408	6	1	4	5.1	CCC(CC)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1nc2ccccc2s1	10.1016/j.bmcl.2009.03.082
	127038399	143535	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	338	6	1	5	4.1	CC(C)Nc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741045	143535	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	338	6	1	5	4.1	CC(C)Nc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	4671033	152140	9	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	339	5	1	3	4.6	Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccccc3)cc2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3913640	152140	9	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	339	5	1	3	4.6	Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccccc3)cc2)cc1	10.1021/acs.jmedchem.6b00685
	127042700	143450	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	302	4	0	5	3.3	Cc1cc(COc2ccccc2C#N)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740222	143450	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	302	4	0	5	3.3	Cc1cc(COc2ccccc2C#N)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	100502467	149631	2	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	357	5	0	3	4.4	CN(c1ccc(Oc2ccccc2)cc1)S(=O)(=O)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3893258	149631	2	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	357	5	0	3	4.4	CN(c1ccc(Oc2ccccc2)cc1)S(=O)(=O)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	44591691	190990	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	349	4	1	3	4.2	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1cc2ccccc2o1	10.1016/j.bmcl.2009.03.082
	CHEMBL483342	190990	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	349	4	1	3	4.2	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1cc2ccccc2o1	10.1016/j.bmcl.2009.03.082
	44591613	191304	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	387	5	1	3	4.9	CCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL484772	191304	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	387	5	1	3	4.9	CCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	127040115	143434	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	401	7	0	5	4.7	Fc1ccc(OCc2cc(OCC3CCC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	CHEMBL3740072	143434	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	401	7	0	5	4.7	Fc1ccc(OCc2cc(OCC3CCC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	127042382	143354	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	5	0	5	3.3	COc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3739442	143354	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	5	0	5	3.3	COc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127042380	143419	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2c(F)cc(F)cc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3739963	143419	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2c(F)cc(F)cc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	674995	149782	14	None	-3	2	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3894632	149782	14	None	-3	2	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	44591692	191013	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	405	5	1	2	5.4	CC[C@H](C)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.03.082
	CHEMBL483545	191013	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	405	5	1	2	5.4	CC[C@H](C)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.03.082
	44591651	191483	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	373	4	1	3	4.5	CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL485025	191483	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	373	4	1	3	4.5	CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	126961699	143458	0	None	-2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	411	5	0	6	3.9	CC1(C#N)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	CHEMBL3740291	143458	0	None	-2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	411	5	0	6	3.9	CC1(C#N)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	127042378	143678	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2c(F)ccc(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3742333	143678	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2c(F)ccc(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127041066	143684	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	324	5	0	5	3.3	CN(C)c1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3742371	143684	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	324	5	0	5	3.3	CN(C)c1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	134134846	151017	0	None	1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3904654	151017	0	None	1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	127040434	143501	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	307	5	0	5	3.4	COc1ccccc1OCc1cc(C)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740758	143501	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	307	5	0	5	3.4	COc1ccccc1OCc1cc(C)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127040748	143509	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	307	5	0	5	3.4	COc1cccc(OCc2cc(C)nc(-c3ccccn3)n2)c1	10.1039/C5MD00037H
	CHEMBL3740835	143509	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	307	5	0	5	3.4	COc1cccc(OCc2cc(C)nc(-c3ccccn3)n2)c1	10.1039/C5MD00037H
	134147328	156828	0	None	-3	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3950610	156828	0	None	-3	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	44591628	191468	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	429	6	1	3	5.9	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2cc(C)cc(C)c2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL485006	191468	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	429	6	1	3	5.9	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2cc(C)cc(C)c2)cc1	10.1016/j.bmcl.2009.03.082
	44244518	191690	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	377	5	1	3	4.8	CC[C@H](C)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1cc2ccccc2o1	10.1016/j.bmcl.2009.03.082
	CHEMBL485328	191690	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	377	5	1	3	4.8	CC[C@H](C)CN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1cc2ccccc2o1	10.1016/j.bmcl.2009.03.082
	25272661	191564	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	339	5	1	3	3.5	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL485146	191564	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	339	5	1	3	3.5	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1	10.1016/j.bmcl.2009.03.082
	44591690	191057	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	343	4	1	2	4.1	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1cccc(Cl)c1	10.1016/j.bmcl.2009.03.082
	CHEMBL483937	191057	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	343	4	1	2	4.1	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1cccc(Cl)c1	10.1016/j.bmcl.2009.03.082
	67134965	157785	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	4	0	3	4.1	O=S1(=O)c2ccccc2CN1c1cc(F)cc(OCc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3958418	157785	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	4	0	3	4.1	O=S1(=O)c2ccccc2CN1c1cc(F)cc(OCc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	127038400	143654	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	400	5	0	5	4.4	CC1(C)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	CHEMBL3742135	143654	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	400	5	0	5	4.4	CC1(C)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	5332902	143380	4	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	288	4	1	4	3.9	Cc1cc(N/N=C/c2ccccc2)nc(-c2ccccc2)n1	10.1039/C5MD00037H
	CHEMBL3739652	143380	4	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	288	4	1	4	3.9	Cc1cc(N/N=C/c2ccccc2)nc(-c2ccccc2)n1	10.1039/C5MD00037H
	127040096	143390	0	None	-1	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2ccc(F)c(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3739712	143390	0	None	-1	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2ccc(F)c(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127040433	143570	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	4	0	4	4.1	Cc1cc(COc2ccc(Cl)cc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741358	143570	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	4	0	4	4.1	Cc1cc(COc2ccc(Cl)cc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127042383	143637	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	325	6	0	5	3.7	CCOc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741974	143637	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	325	6	0	5	3.7	CCOc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127042701	143527	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	302	4	0	5	3.3	Cc1cc(COc2cccc(C#N)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740984	143527	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	302	4	0	5	3.3	Cc1cc(COc2cccc(C#N)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	134154953	158055	0	None	-7	2	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3960369	158055	0	None	-7	2	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	805130	101813	13	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assayAntagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assay	ChEMBL	348	6	1	4	4.3	O=C(NCc1cccc(Oc2ccccc2)c1)c1ccc([N+](=O)[O-])cc1	10.1021/jm7012425
	CHEMBL255074	101813	13	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assayAntagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assay	ChEMBL	348	6	1	4	4.3	O=C(NCc1cccc(Oc2ccccc2)c1)c1ccc([N+](=O)[O-])cc1	10.1021/jm7012425
	134138099	154600	0	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3932897	154600	0	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	44591630	198263	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	470	6	1	4	5.7	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccc(C(F)(F)F)cn2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL519358	198263	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	470	6	1	4	5.7	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccc(C(F)(F)F)cn2)cc1	10.1016/j.bmcl.2009.03.082
	44591629	191469	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	429	6	1	3	5.9	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccc(C)c(C)c2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL485007	191469	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	429	6	1	3	5.9	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Oc2ccc(C)c(C)c2)cc1	10.1016/j.bmcl.2009.03.082
	127040388	143534	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	4	0	4	4.1	Cc1cc(COc2ccccc2Cl)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741030	143534	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	4	0	4	4.1	Cc1cc(COc2ccccc2Cl)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127040116	143575	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	403	7	0	6	3.6	Fc1ccc(OCc2cc(OCC3COC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	CHEMBL3741385	143575	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	403	7	0	6	3.6	Fc1ccc(OCc2cc(OCC3COC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	127040723	143627	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	388	5	1	6	2.7	OC1CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	CHEMBL3741899	143627	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	388	5	1	6	2.7	OC1CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	127042702	143608	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	302	4	0	5	3.3	Cc1cc(COc2ccc(C#N)cc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741704	143608	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	302	4	0	5	3.3	Cc1cc(COc2ccc(C#N)cc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	134141650	153477	0	None	1	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3923955	153477	0	None	1	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	134145778	156126	0	None	-13	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3945213	156126	0	None	-13	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	127040118	143367	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	442	8	0	7	3.8	N#CCC1(COc2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)COC1	10.1039/C5MD00037H
	CHEMBL3739522	143367	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	442	8	0	7	3.8	N#CCC1(COc2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)COC1	10.1039/C5MD00037H
	127039708	143441	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	4	0	4	4.1	Cc1cc(COc2cccc(Cl)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740168	143441	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	311	4	0	4	4.1	Cc1cc(COc2cccc(Cl)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127040059	143459	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	295	4	0	4	3.6	Cc1cc(COc2ccccc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740298	143459	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	295	4	0	4	3.6	Cc1cc(COc2ccccc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127042381	143477	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2cc(F)c(F)c(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740515	143477	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2cc(F)c(F)c(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127042379	143518	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2cc(F)c(F)cc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740906	143518	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2cc(F)c(F)cc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127038708	143543	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	313	4	0	4	3.7	Cc1cc(COc2ccc(F)cc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741109	143543	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	313	4	0	4	3.7	Cc1cc(COc2ccc(F)cc2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127040094	143557	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	313	4	0	4	3.7	Cc1cc(COc2cccc(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741230	143557	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	313	4	0	4	3.7	Cc1cc(COc2cccc(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	44591652	198374	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	413	6	1	3	5.3	O=C(O)[C@@H]1c2ccccc2C(=O)N(CC2CC2)[C@H]1c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL519525	198374	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	413	6	1	3	5.3	O=C(O)[C@@H]1c2ccccc2C(=O)N(CC2CC2)[C@H]1c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	134153067	159035	0	None	-16	2	Human	4.4	pIC50	=	4.4	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3969073	159035	0	None	-16	2	Human	4.4	pIC50	=	4.4	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	127038401	143562	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	414	5	0	6	3.5	Fc1ccc(OCc2cc(N3CC4(CCO4)C3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	CHEMBL3741297	143562	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	414	5	0	6	3.5	Fc1ccc(OCc2cc(N3CC4(CCO4)C3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	127040095	143593	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	313	4	0	4	3.7	Cc1cc(COc2ccc(F)c(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741570	143593	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	313	4	0	4	3.7	Cc1cc(COc2ccc(F)c(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127039385	143595	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	433	8	0	7	3.3	COC1(COc2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)COC1	10.1039/C5MD00037H
	CHEMBL3741582	143595	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	433	8	0	7	3.3	COC1(COc2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)COC1	10.1039/C5MD00037H
	127040097	143631	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2cc(F)cc(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741919	143631	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2cc(F)cc(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	2233248	175642	9	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assayAntagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assay	ChEMBL	334	5	1	4	4.6	O=C(Nc1ccccc1)c1cccc(Oc2ccc([N+](=O)[O-])cc2)c1	10.1021/jm7012425
	CHEMBL438164	175642	9	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assayAntagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assay	ChEMBL	334	5	1	4	4.6	O=C(Nc1ccccc1)c1cccc(Oc2ccc([N+](=O)[O-])cc2)c1	10.1021/jm7012425
	134152545	160256	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3979588	160256	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	127041988	143612	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	421	7	0	6	3.7	Fc1ccc(OCc2cc(OCC3(F)COC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	CHEMBL3741735	143612	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	421	7	0	6	3.7	Fc1ccc(OCc2cc(OCC3(F)COC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	58137077	143391	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	348	5	0	6	3.0	c1ccc(OCc2cc(N3CCOCC3)nc(-c3ccccn3)n2)cc1	10.1039/C5MD00037H
	CHEMBL3739715	143391	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	348	5	0	6	3.0	c1ccc(OCc2cc(N3CCOCC3)nc(-c3ccccn3)n2)cc1	10.1039/C5MD00037H
	127040093	143462	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	295	4	0	4	3.6	Cc1cc(COc2ccc(F)cc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740314	143462	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	295	4	0	4	3.6	Cc1cc(COc2ccc(F)cc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127042713	143625	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	324	6	1	5	3.7	CCNc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3741858	143625	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	324	6	1	5	3.7	CCNc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127038402	143569	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	478	7	0	7	3.4	CC1(CS(C)(=O)=O)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	CHEMBL3741353	143569	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	478	7	0	7	3.4	CC1(CS(C)(=O)=O)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
	127038403	143568	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	415	6	0	5	4.5	Fc1ccc(OCc2cc(OCC(F)(F)F)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	CHEMBL3741349	143568	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	415	6	0	5	4.5	Fc1ccc(OCc2cc(OCC(F)(F)F)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
	127040117	143483	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	417	7	0	6	4.0	CC1(COc2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)COC1	10.1039/C5MD00037H
	CHEMBL3740598	143483	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	417	7	0	6	4.0	CC1(COc2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)COC1	10.1039/C5MD00037H
	127040432	143478	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	277	4	0	4	3.4	Cc1cc(COc2ccccc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740555	143478	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	277	4	0	4	3.4	Cc1cc(COc2ccccc2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127039748	143504	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	295	4	0	4	3.6	Cc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	CHEMBL3740771	143504	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	295	4	0	4	3.6	Cc1cc(COc2cccc(F)c2)nc(-c2ccccn2)n1	10.1039/C5MD00037H
	127040749	143361	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	307	5	0	5	3.4	COc1ccc(OCc2cc(C)nc(-c3ccccn3)n2)cc1	10.1039/C5MD00037H
	CHEMBL3739500	143361	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysisAntagonist activity against human GPR40 expressed in HEK293s FLPIN cells assessed as elaidic acid stimulated IP1 release after 2 hrs by TR-FRET analysis	ChEMBL	307	5	0	5	3.4	COc1ccc(OCc2cc(C)nc(-c3ccccn3)n2)cc1	10.1039/C5MD00037H
	2843133	154425	51	None	-1	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3931570	154425	51	None	-1	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assayAntagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
	44591689	191056	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	377	4	1	2	4.8	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.03.082
	CHEMBL483936	191056	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	377	4	1	2	4.8	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.03.082
	44591627	191701	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	415	7	1	3	5.0	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	CHEMBL485335	191701	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAntagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	415	7	1	3	5.0	CCCN1C(=O)c2ccccc2[C@@H](C(=O)O)[C@@H]1c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2009.03.082
	5280933	184999	64	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	Drug Central	278	13	1	1	5.7	CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O	None
	CHEMBL464982	184999	64	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayAgonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay	Drug Central	278	13	1	1	5.7	CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O	None
	1049	7151	75	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	Drug Central	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	None
	4618	7151	75	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	Drug Central	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	None
	5280934	7151	75	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	Drug Central	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	None
	CHEMBL8739	7151	75	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	Drug Central	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	None
	DB00132	7151	75	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assayAgonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay	Drug Central	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	None
	1056	10144	116	None	15	10	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	None
	2405	10144	116	None	15	10	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	None
	77999	10144	116	None	15	10	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	None
	CHEMBL121	10144	116	None	15	10	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	None
	DB00412	10144	116	None	15	10	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	None
	1052	9101	85	None	-5	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	3323	9101	85	None	-5	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	5280450	9101	85	None	-5	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	CHEMBL267476	9101	85	None	-5	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	DB14104	9101	85	None	-5	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	1054	9691	85	None	1	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	3400	9691	85	None	1	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	445639	9691	85	None	1	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	CHEMBL8659	9691	85	None	1	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	1051	8237	63	None	-14	2	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	None
	4289	8237	63	None	-14	2	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	None
	445580	8237	63	None	-14	2	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	None
	57417355	8237	63	None	-14	2	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	None
	CHEMBL367149	8237	63	None	-14	2	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	None
	DB03756	8237	63	None	-14	2	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	None
	3893	9067	98	None	-1	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	Drug Central	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	None
	4642	9067	98	None	-1	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	Drug Central	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	None
	5534	9067	98	None	-1	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	Drug Central	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	None
	CHEMBL108766	9067	98	None	-1	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	Drug Central	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	None
	DB03017	9067	98	None	-1	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assayAgonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay	Drug Central	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	None
	10043	10366	0	None	-2	2	Human	3.0	pEC50	=	3.0	Functional	In a β-arrestin 2 recruitment assay measured by BRET.In a β-arrestin 2 recruitment assay measured by BRET.	Guide to Pharmacology	206	6	1	1	3.0	CCCCCc1cccc(c1)CC(=O)O	29454750
	24749700	10366	0	None	-2	2	Human	3.0	pEC50	=	3.0	Functional	In a β-arrestin 2 recruitment assay measured by BRET.In a β-arrestin 2 recruitment assay measured by BRET.	Guide to Pharmacology	206	6	1	1	3.0	CCCCCc1cccc(c1)CC(=O)O	29454750
	CHEMBL4297635	10366	0	None	-2	2	Human	3.0	pEC50	=	3.0	Functional	In a β-arrestin 2 recruitment assay measured by BRET.In a β-arrestin 2 recruitment assay measured by BRET.	Guide to Pharmacology	206	6	1	1	3.0	CCCCCc1cccc(c1)CC(=O)O	29454750
	DB15447	10366	0	None	-2	2	Human	3.0	pEC50	=	3.0	Functional	In a β-arrestin 2 recruitment assay measured by BRET.In a β-arrestin 2 recruitment assay measured by BRET.	Guide to Pharmacology	206	6	1	1	3.0	CCCCCc1cccc(c1)CC(=O)O	29454750
	1055	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12496284
	1055	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12565875
	1055	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12629551
	135369651	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12496284
	135369651	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12565875
	135369651	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12629551
	985	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12496284
	985	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12565875
	985	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12629551
	CHEMBL82293	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12496284
	CHEMBL82293	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12565875
	CHEMBL82293	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12629551
	DB03796	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12496284
	DB03796	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12565875
	DB03796	9768	105	None	-2884	2	Human	4.6	pEC50	=	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	14	1	1	5.6	CCCCCCCCCCCCCCCC(=O)O	12629551
	1054	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12496284
	1054	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12565875
	1054	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12629551
	3400	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12496284
	3400	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12565875
	3400	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12629551
	445639	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12496284
	445639	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12565875
	445639	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12629551
	CHEMBL8659	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12496284
	CHEMBL8659	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12565875
	CHEMBL8659	9691	85	None	1	5	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	12629551
	11005	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12496284
	11005	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12565875
	11005	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12629551
	2806	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12496284
	2806	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12565875
	2806	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12629551
	CHEMBL111077	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12496284
	CHEMBL111077	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12565875
	CHEMBL111077	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12629551
	DB08231	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12496284
	DB08231	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12565875
	DB08231	9471	107	None	-2	3	Human	4.8	pEC50	=	4.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	12629551
	1052	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	1052	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	1052	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	3323	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	3323	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	3323	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	5280450	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	5280450	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	5280450	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	CHEMBL267476	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	CHEMBL267476	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	CHEMBL267476	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	DB14104	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	DB14104	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	DB14104	9101	85	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	1049	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	1049	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	1049	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	4618	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	4618	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	4618	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	5280934	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	5280934	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	5280934	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	CHEMBL8739	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	CHEMBL8739	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	CHEMBL8739	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	DB00132	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12496284
	DB00132	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12565875
	DB00132	7151	75	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	12629551
	1051	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12496284
	1051	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12629551
	4289	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12496284
	4289	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12629551
	445580	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12496284
	445580	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12629551
	57417355	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12496284
	57417355	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12629551
	CHEMBL367149	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12496284
	CHEMBL367149	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12629551
	DB03756	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12496284
	DB03756	8237	63	None	-14	2	Human	5.7	pEC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	328	14	1	1	6.5	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O	12629551
	3367	7939	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	18477808
	46216676	7939	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	18477808
	CHEMBL604126	7939	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	18477808
	24857286	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	21752941
	24857286	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	24900210
	24857286	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25043059
	24857286	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25787200
	6484	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	21752941
	6484	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	24900210
	6484	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25043059
	6484	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25787200
	CHEMBL1829174	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	21752941
	CHEMBL1829174	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	24900210
	CHEMBL1829174	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25043059
	CHEMBL1829174	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25787200
	DB12491	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	21752941
	DB12491	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	24900210
	DB12491	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25043059
	DB12491	8405	72	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	25787200
	1050	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	11595431	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	CHEMBL207881	8683	94	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	25150014	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	18947221
	3952	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	18947221
	CHEMBL449588	10657	55	None	44	2	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	18947221
	10668	8734	16	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	366	7	1	3	4.8	OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C	31971610
	139600331	8734	16	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	366	7	1	3	4.8	OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C	31971610
	CHEMBL5169614	8734	16	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	366	7	1	3	4.8	OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C	31971610
	60195125	10660	8	None	4	3	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	22724451
	9149	10660	8	None	4	3	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	22724451
	CHEMBL2164242	10660	8	None	4	3	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	22724451
	6483	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	23687558
	66553168	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	23687558
	CHEMBL2386353	10658	54	None	13	4	Human	8.2	pEC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	23687558
	46854655	7183	47	None	-8	3	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	22859723
	6485	7183	47	None	-8	3	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	22859723
	CHEMBL1829173	7183	47	None	-8	3	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	22859723
	1056	10144	116	None	15	10	Human	5.6	pEC50	None	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	12565875
	2405	10144	116	None	15	10	Human	5.6	pEC50	None	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	12565875
	77999	10144	116	None	15	10	Human	5.6	pEC50	None	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	12565875
	CHEMBL121	10144	116	None	15	10	Human	5.6	pEC50	None	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	12565875
	DB00412	10144	116	None	15	10	Human	5.6	pEC50	None	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	12565875
	1053	9260	0	None	-	1	Human	5.9	pEC50	None	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	342	15	2	2	5.9	OC(=O)CC(CCCCCCCCCCC(CC(=O)O)(C)C)(C)C	12565875
	121871	9260	0	None	-	1	Human	5.9	pEC50	None	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	342	15	2	2	5.9	OC(=O)CC(CCCCCCCCCCC(CC(=O)O)(C)C)(C)C	12565875
	CHEMBL63829	9260	0	None	-	1	Human	5.9	pEC50	None	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	342	15	2	2	5.9	OC(=O)CC(CCCCCCCCCCC(CC(=O)O)(C)C)(C)C	12565875
	1057	8675	0	None	-	1	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	520	10	0	9	4.6	CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F	16702987
	1057	8675	0	None	-	1	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	520	10	0	9	4.6	CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F	17200419
	11692123	8675	0	None	-	1	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	520	10	0	9	4.6	CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F	16702987
	11692123	8675	0	None	-	1	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	520	10	0	9	4.6	CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F	17200419
	CHEMBL4303679	8675	0	None	-	1	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	520	10	0	9	4.6	CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F	16702987
	CHEMBL4303679	8675	0	None	-	1	Human	6.0	pIC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	520	10	0	9	4.6	CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F	17200419

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		162673875	189765	0	None	-	1	Mouse	9.4	pEC50	=	9.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4793371	189765	0	None	-	1	Mouse	9.4	pEC50	=	9.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		52936292	188889	27	None	-	1	Mouse	9.3	pEC50	=	9.3	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4782004	188889	27	None	-	1	Mouse	9.3	pEC50	=	9.3	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		67087100	189377	0	None	-	1	Mouse	9.3	pEC50	=	9.3	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4788206	189377	0	None	-	1	Mouse	9.3	pEC50	=	9.3	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162673875	189765	0	None	-	1	Rat	9.3	pEC50	=	9.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4793371	189765	0	None	-	1	Rat	9.3	pEC50	=	9.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		67087041	189150	0	None	-	1	Mouse	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4785057	189150	0	None	-	1	Mouse	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		67087100	189377	0	None	-	1	Rat	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4788206	189377	0	None	-	1	Rat	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		67087095	190154	0	None	-	1	Mouse	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797858	190154	0	None	-	1	Mouse	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		68194465	190085	0	None	-	1	Mouse	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797124	190085	0	None	-	1	Mouse	9.2	pEC50	=	9.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		134139282	153270	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	501	11	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)CC(F)(F)F)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3922381	153270	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	501	11	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)CC(F)(F)F)c2)cc1	10.1021/acsmedchemlett.6b00331
		162668378	189286	0	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787010	189286	0	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		162674654	190234	0	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798993	190234	0	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		67087095	190154	0	None	-	1	Rat	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797858	190154	0	None	-	1	Rat	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		51049992	152397	5	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3915620	152397	5	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		67087246	189656	5	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4791842	189656	5	None	-	1	Mouse	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		67087041	189150	0	None	-	1	Rat	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4785057	189150	0	None	-	1	Rat	9.1	pEC50	=	9.1	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		52936292	188889	27	None	-	1	Rat	9.0	pEC50	=	9.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4782004	188889	27	None	-	1	Rat	9.0	pEC50	=	9.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		71257551	157372	24	None	-	1	Mouse	9.0	pEC50	=	9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3955132	157372	24	None	-	1	Mouse	9.0	pEC50	=	9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.6b00892
		162674654	190234	0	None	-	1	Rat	9.0	pEC50	=	9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798993	190234	0	None	-	1	Rat	9.0	pEC50	=	9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		162668378	189286	0	None	-	1	Rat	9.0	pEC50	=	9.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787010	189286	0	None	-	1	Rat	9.0	pEC50	=	9.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		68194465	190085	0	None	-	1	Rat	9.0	pEC50	=	9.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797124	190085	0	None	-	1	Rat	9.0	pEC50	=	9.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		162668378	189286	0	None	-	1	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787010	189286	0	None	-	1	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		68194743	189327	12	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787498	189327	12	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		162674998	190170	0	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798023	190170	0	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		162676881	190364	0	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4800563	190364	0	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		45254027	97080	10	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	514	7	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL2385460	97080	10	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	514	7	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/acsmedchemlett.2c00160
		67087246	189656	5	None	-	1	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4791842	189656	5	None	-	1	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162674998	190170	0	None	-	1	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798023	190170	0	None	-	1	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		162664735	188865	0	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4781604	188865	0	None	-	1	Mouse	8.9	pEC50	=	8.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		134136015	150985	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	475	12	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)CC(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3904378	150985	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	475	12	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)CC(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		46854655	7183	47	None	-	1	Mouse	8.8	pEC50	=	8.8	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		6485	7183	47	None	-	1	Mouse	8.8	pEC50	=	8.8	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		CHEMBL1829173	7183	47	None	-	1	Mouse	8.8	pEC50	=	8.8	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		67087095	190154	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797858	190154	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		68194743	189327	12	None	-	1	Rat	8.8	pEC50	=	8.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787498	189327	12	None	-	1	Rat	8.8	pEC50	=	8.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		162673875	189765	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4793371	189765	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		24857286	8405	72	None	10	2	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		6484	8405	72	None	10	2	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		CHEMBL1829174	8405	72	None	10	2	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		DB12491	8405	72	None	10	2	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		134134433	150011	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	510	12	1	5	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccncc3)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3896509	150011	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	510	12	1	5	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccncc3)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		134150797	158764	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	459	11	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3966739	158764	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	459	11	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		134137203	149617	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	523	12	1	5	5.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)S(=O)(=O)C3CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3893141	149617	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	523	12	1	5	5.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)S(=O)(=O)C3CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		162664735	188865	0	None	-	1	Human	8.0	pEC50	=	8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4781604	188865	0	None	-	1	Human	8.0	pEC50	=	8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		68194159	189840	0	None	-	1	Rat	7.0	pEC50	=	7	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4794233	189840	0	None	-	1	Rat	7.0	pEC50	=	7	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		67087160	189123	0	None	-	1	Human	7.0	pEC50	=	7	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4784555	189123	0	None	-	1	Human	7.0	pEC50	=	7	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5271504	200466	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	544	13	1	7	5.0	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](OCCCOC)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5285139	201059	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)ccc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		11961321	118576	4	None	-	0	Human	5.0	pEC50	=	5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3287569	118576	4	None	-	0	Human	5.0	pEC50	=	5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		127033514	145558	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	381	6	1	5	4.6	Cc1nc(-c2ccccc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		CHEMBL3780725	145558	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	381	6	1	5	4.6	Cc1nc(-c2ccccc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		46854655	7183	47	None	-	1	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml400501x
		6485	7183	47	None	-	1	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml400501x
		CHEMBL1829173	7183	47	None	-	1	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml400501x
		156010524	183895	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4cccc(C)c4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4633625	183895	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4cccc(C)c4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		57705838	118021	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	508	10	1	3	8.1	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@H](F)C(C)(C)C)c1	10.1021/ml4005123
		CHEMBL3265139	118021	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	508	10	1	3	8.1	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@H](F)C(C)(C)C)c1	10.1021/ml4005123
		58379987	97084	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	547	7	1	4	7.6	COc1cc(-c2ccc(COc3ccc4c(c3F)[C@]3(CCC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml300427u
		CHEMBL2385464	97084	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	547	7	1	4	7.6	COc1cc(-c2ccc(COc3ccc4c(c3F)[C@]3(CCC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml300427u
		127033821	145594	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	415	6	1	5	5.3	Cc1nc(-c2ccc(Cl)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		CHEMBL3781162	145594	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	415	6	1	5	5.3	Cc1nc(-c2ccc(Cl)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		90655860	118026	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	518	10	1	5	7.1	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265144	118026	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	518	10	1	5	7.1	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		91809187	153902	13	None	-	1	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL3927519	153902	13	None	-	1	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		67087160	189123	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4784555	189123	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		68194449	189593	0	None	-	1	Rat	8.0	pEC50	=	8.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4790921	189593	0	None	-	1	Rat	8.0	pEC50	=	8.0	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		46854655	7183	47	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		6485	7183	47	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		CHEMBL1829173	7183	47	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		67087246	189656	5	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4791842	189656	5	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		46941175	68586	26	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b00202
		CHEMBL1773261	68586	26	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b00202
		58230598	189898	0	None	-	1	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		CHEMBL4794904	189898	0	None	-	1	Mouse	7.0	pEC50	=	7.0	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		CHEMBL5266348	200256	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	564	11	1	7	5.8	CCOc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](Oc5cccc(OC)c5)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5267060	200288	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	473	7	1	6	4.7	COc1cc(N2CC[C@@H](Oc3ccc(N4CC[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		132606863	164602	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cellsPositive allosteric modulation of human GPR40 expressed in HEK293 cells	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmc.2023.117273
		CHEMBL4083365	164602	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cellsPositive allosteric modulation of human GPR40 expressed in HEK293 cells	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5290549	201280	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	436	8	2	7	3.3	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5290651	201285	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	432	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5277986	200740	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3C)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5281518	200893	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	409	5	2	8	3.8	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4cccc(Cl)c4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		155530111	178272	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	391	7	1	5	4.4	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		CHEMBL4463798	178272	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	391	7	1	5	4.4	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		127036748	144295	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	496	9	1	5	6.2	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754173	144295	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	496	9	1	5	6.2	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2015.11.050
		127029850	145516	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		CHEMBL3780211	145516	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		57707214	118023	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	534	12	1	4	8.2	CCO[C@@H](c1cc(COc2cccc([C@@H](CC(=O)O)C3CC3)c2)ccc1-c1cc(OC)ccc1F)C(C)(C)C	10.1021/ml4005123
		CHEMBL3265141	118023	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	534	12	1	4	8.2	CCO[C@@H](c1cc(COc2cccc([C@@H](CC(=O)O)C3CC3)c2)ccc1-c1cc(OC)ccc1F)C(C)(C)C	10.1021/ml4005123
		1056	10144	116	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1016/j.bmcl.2014.07.043
		2405	10144	116	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1016/j.bmcl.2014.07.043
		77999	10144	116	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1016/j.bmcl.2014.07.043
		CHEMBL121	10144	116	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1016/j.bmcl.2014.07.043
		DB00412	10144	116	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1016/j.bmcl.2014.07.043
		134138359	154399	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	419	10	2	4	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CNCc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3931296	154399	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	419	10	2	4	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CNCc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		15604310	118578	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	462	8	1	6	5.0	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nnnn3C)cc2)c1	10.1021/ml400501x
		CHEMBL3287571	118578	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	462	8	1	6	5.0	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nnnn3C)cc2)c1	10.1021/ml400501x
		134155821	157706	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	463	12	2	5	4.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(CCO)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3957744	157706	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	463	12	2	5	4.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(CCO)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		24857286	8405	72	None	10	2	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		6484	8405	72	None	10	2	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		CHEMBL1829174	8405	72	None	10	2	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		DB12491	8405	72	None	10	2	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		57705806	117991	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	515	10	1	4	7.6	COc1cc(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3264817	117991	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	515	10	1	4	7.6	COc1cc(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		162666840	189233	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4786299	189233	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		132578495	189665	2	None	-	1	Rat	6.9	pEC50	=	6.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792027	189665	2	None	-	1	Rat	6.9	pEC50	=	6.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		59132613	144040	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	483	8	1	4	7.0	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1nccs1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752026	144040	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	483	8	1	4	7.0	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1nccs1	10.1016/j.bmcl.2015.11.050
		CHEMBL5284294	201028	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	556	11	1	8	5.0	COc1cc(N2CC[C@@H](Oc3ccc(N4C[C@H](OCCCC#N)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		CHEMBL5285235	201066	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	507	8	1	7	4.1	COc1cc(N2CC[C@@H](Oc3ccc(N4C[C@H](F)[C@@H](OC)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		CHEMBL5269688	200384	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5278791	200775	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5288405	201202	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	448	9	2	8	3.1	COc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5092999	222179	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	IPOne assayIPOne assay	ChEMBL		None	None	None		COCCCS(=O)(=O)c1cc(C)c(-c2ccc(F)c3c2CC[C@H]3Oc2ccc3c(c2)OC[C@H]3CC(=O)O)c(C)c1	10.6019/CHEMBL5058643
		156021111	184831	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	410	7	1	4	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4647211	184831	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	410	7	1	4	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		59590781	118029	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	517	8	1	4	7.4	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265147	118029	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	517	8	1	4	7.4	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL5289774	201259	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	375	5	2	8	3.2	Cc1ccc(Nc2nc(N)nc(COc3ccc4ccc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
		46854655	7183	47	None	-	1	Human	7.9	pEC50	=	7.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		6485	7183	47	None	-	1	Human	7.9	pEC50	=	7.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		CHEMBL1829173	7183	47	None	-	1	Human	7.9	pEC50	=	7.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		58758896	144330	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	480	8	1	4	6.3	Cn1ccnc1C(CC(=O)O)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754486	144330	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	480	8	1	4	6.3	Cn1ccnc1C(CC(=O)O)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL5276368	200675	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	510	7	1	5	5.5	COc1ccc(F)c(N2CC[C@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C[C@@H]2C)c1	10.1016/j.bmc.2023.117273
		90176463	121038	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	528	8	1	4	7.0	CCC1C(C(F)(F)F)=NN(c2ccc(Cc3ccc(-c4cc(OC)ccc4F)cc3C)cc2)C1CC(=O)O	10.1021/ml5002757
		CHEMBL3330549	121038	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	528	8	1	4	7.0	CCC1C(C(F)(F)F)=NN(c2ccc(Cc3ccc(-c4cc(OC)ccc4F)cc3C)cc2)C1CC(=O)O	10.1021/ml5002757
		CHEMBL5285406	201076	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	417	5	2	9	3.2	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc5c(c4)COC5)n3)ccc12	10.1021/acsmedchemlett.2c00160
		155523655	177682	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	357	7	1	5	3.8	Cc1nc(-c2ccccc2)oc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		CHEMBL4454699	177682	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	357	7	1	5	3.8	Cc1nc(-c2ccccc2)oc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		134465785	182890	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assayAgonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
		CHEMBL4591657	182890	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assayAgonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assay	ChEMBL	426	9	1	3	6.2	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@@H](CC(=O)O)C4CC4)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
		73356502	97088	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	486	8	1	3	7.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H]4C[C@H]4C(=O)O)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385471	97088	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	486	8	1	3	7.5	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H]4C[C@H]4C(=O)O)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		91809187	153902	13	None	-	1	Rat	7.9	pEC50	=	7.9	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL3927519	153902	13	None	-	1	Rat	7.9	pEC50	=	7.9	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL5285988	201104	0	None	-	0	Mouse	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of mouse GPR40Positive allosteric modulation of mouse GPR40	ChEMBL	561	12	1	8	4.8	COCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		60195125	10660	8	None	-	1	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		9149	10660	8	None	-	1	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		CHEMBL2164242	10660	8	None	-	1	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		CHEMBL5290885	201296	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	423	5	2	8	4.2	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		134134768	151105	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	516	11	1	5	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCN(C)CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3905435	151105	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	516	11	1	5	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCN(C)CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL5265829	200235	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	484	8	1	5	5.6	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4CC(C)(C)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		130253300	165890	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cellsPositive allosteric modulation of human GPR40 expressed in HEK293 cells	ChEMBL	428	7	1	5	4.3	COc1ccc(F)c(N2CCC(Oc3ccc(N4CCC[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		CHEMBL4097617	165890	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cellsPositive allosteric modulation of human GPR40 expressed in HEK293 cells	ChEMBL	428	7	1	5	4.3	COc1ccc(F)c(N2CCC(Oc3ccc(N4CCC[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5273939	200566	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(C)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		162644059	188603	0	None	-	1	Rat	4.9	pEC50	=	4.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		CHEMBL4778264	188603	0	None	-	1	Rat	4.9	pEC50	=	4.9	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		57706451	118025	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	520	11	1	4	7.8	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H](OC)C(C)(C)C)c1	10.1021/ml4005123
		CHEMBL3265143	118025	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	520	11	1	4	7.8	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H](OC)C(C)(C)C)c1	10.1021/ml4005123
		CHEMBL5278350	200756	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		71816761	97085	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	498	7	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@@H]3[C@@H](C(=O)O)[C@@H]3C4)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385466	97085	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	498	7	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@@H]3[C@@H](C(=O)O)[C@@H]3C4)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		57706220	118022	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	520	11	1	4	7.8	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/ml4005123
		CHEMBL3265140	118022	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	520	11	1	4	7.8	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@H](OC)C(C)(C)C)c1	10.1021/ml4005123
		155563228	182085	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	441	7	1	5	5.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		CHEMBL4573403	182085	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	441	7	1	5	5.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		118129974	163973	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4075819	163973	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		90655861	118027	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	506	10	1	5	7.1	CC[C@H](CC(=O)O)c1ccnc(OCc2ccc(-c3cc(OC)ncc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/ml4005123
		CHEMBL3265145	118027	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	506	10	1	5	7.1	CC[C@H](CC(=O)O)c1ccnc(OCc2ccc(-c3cc(OC)ncc3F)c([C@@H]3CCCC3(C)C)c2)c1	10.1021/ml4005123
		58380381	97090	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	526	7	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CCC4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385473	97090	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	526	7	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CCC4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL5288340	201196	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	482	9	2	8	3.9	COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1	10.1021/acsmedchemlett.2c00160
		156017497	184635	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4cccc(C)c4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4644239	184635	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4cccc(C)c4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		46854655	7183	47	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
		6485	7183	47	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
		CHEMBL1829173	7183	47	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
		127029851	145640	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	411	7	1	6	4.7	COc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL3781779	145640	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	411	7	1	6	4.7	COc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2018.12.069
		155547595	180444	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	387	7	1	5	4.6	Cc1ccc(-c2nc(C)c(COc3ccc(OCC(=O)O)c(F)c3)s2)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4534812	180444	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	387	7	1	5	4.6	Cc1ccc(-c2nc(C)c(COc3ccc(OCC(=O)O)c(F)c3)s2)cc1	10.1016/j.ejmech.2018.12.069
		156013146	184246	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	454	9	1	5	5.6	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4OCC)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4639050	184246	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	454	9	1	5	5.6	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4OCC)cn3c2)cc1	10.1016/j.bmc.2020.115574
		162667620	189336	0	None	-	1	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4787628	189336	0	None	-	1	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		134137248	149875	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	473	12	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)CC3CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3895442	149875	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	473	12	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)CC3CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		134138706	154676	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	551	11	1	6	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCS(=O)(=O)CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3933446	154676	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	551	11	1	6	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCS(=O)(=O)CC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL5266881	200279	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	458	6	2	7	4.5	Cc1ccc(Nc2nc(N)nc(COc3cc(Cl)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5273250	200533	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	437	6	2	8	4.4	CCc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		58230552	188998	0	None	-	1	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4783190	188998	0	None	-	1	Rat	6.8	pEC50	=	6.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		57706778	87572	29	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2152070	87572	29	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL5282952	200957	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	530	13	1	7	4.7	CCOc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](OCCCOC)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5268182	200329	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(F)ccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5278391	200758	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		57706778	87572	29	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml4005123
		CHEMBL2152070	87572	29	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml4005123
		86288852	118031	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	522	11	1	6	6.6	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265149	118031	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	522	11	1	6	6.6	COc1cc(-c2ccc(COc3cc([C@@H](CC(=O)O)C4CC4)ccn3)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
		118151370	165882	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4097527	165882	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		68194237	188985	0	None	-	1	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4783033	188985	0	None	-	1	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		68194449	189593	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4790921	189593	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		168298569	199458	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	389	5	2	8	3.5	Cc1cccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5219055	199458	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	389	5	2	8	3.5	Cc1cccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5284985	201053	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	389	5	2	8	3.5	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
		68194159	189840	0	None	-	1	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4794233	189840	0	None	-	1	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		67087160	189123	0	None	-	1	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4784555	189123	0	None	-	1	Rat	7.8	pEC50	=	7.8	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5281753	200903	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of mouse GPR40Positive allosteric modulation of mouse GPR40	ChEMBL	558	13	1	7	5.2	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](OCCCOC)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		6483	10658	54	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
		66553168	10658	54	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
		CHEMBL2386353	10658	54	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
		68265494	97087	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	512	7	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385470	97087	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	512	7	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL5275737	200648	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	486	9	1	6	4.6	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](OC)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5277523	200716	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	577	13	1	9	4.3	COCCOCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		CHEMBL5287383	201161	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	524	8	1	5	5.8	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5281423	200890	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5287642	201167	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	7	2	8	3.9	COc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5285988	201104	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	561	12	1	8	4.8	COCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		CHEMBL5266810	200273	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	393	5	2	8	3.3	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(F)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		155525700	177819	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	391	7	1	5	4.4	Cc1nc(-c2cccc(F)c2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		CHEMBL4456869	177819	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	391	7	1	5	4.4	Cc1nc(-c2cccc(F)c2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		46941175	68586	26	None	-	1	Mouse	7.7	pEC50	=	7.7	Binding	Activation of FFA1 in mouse islets assessed as glucose-dependent insulin secretionActivation of FFA1 in mouse islets assessed as glucose-dependent insulin secretion	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
		CHEMBL1773261	68586	26	None	-	1	Mouse	7.7	pEC50	=	7.7	Binding	Activation of FFA1 in mouse islets assessed as glucose-dependent insulin secretionActivation of FFA1 in mouse islets assessed as glucose-dependent insulin secretion	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/ml100106c
		75204006	121037	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	484	7	1	5	6.4	COc1cccc(-c2ccc(Oc3ccc(N4N=C(C(F)(F)F)CC4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		CHEMBL3330548	121037	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	484	7	1	5	6.4	COc1cccc(-c2ccc(Oc3ccc(N4N=C(C(F)(F)F)CC4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		68676271	144092	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	477	8	1	3	7.0	O=C(O)CC(c1ccncc1)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752557	144092	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	477	8	1	3	7.0	O=C(O)CC(c1ccncc1)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		127035472	144154	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	482	8	1	3	7.6	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1cccs1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753088	144154	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	482	8	1	3	7.6	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1cccs1	10.1016/j.bmcl.2015.11.050
		CHEMBL5278354	200757	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	531	10	1	7	5.1	CCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		CHEMBL5282559	200938	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	559	12	1	7	5.9	CCCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		162649435	186819	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4747554	186819	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		67087173	189239	0	None	-	1	Mouse	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4786335	189239	0	None	-	1	Mouse	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		51049992	152397	5	None	-	1	Rat	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3915620	152397	5	None	-	1	Rat	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		134140466	153413	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	501	11	1	4	7.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCCCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3923431	153413	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	501	11	1	4	7.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCCCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		68194476	189666	0	None	-	1	Mouse	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792075	189666	0	None	-	1	Mouse	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		162676686	190265	0	None	-	1	Mouse	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4799453	190265	0	None	-	1	Mouse	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162676881	190364	0	None	-	1	Rat	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4800563	190364	0	None	-	1	Rat	8.7	pEC50	=	8.7	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		134129919	149185	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	515	12	1	5	7.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3889768	149185	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	515	12	1	5	7.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		46854655	7183	47	None	-	1	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acsmedchemlett.6b00331
		6485	7183	47	None	-	1	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acsmedchemlett.6b00331
		CHEMBL1829173	7183	47	None	-	1	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acsmedchemlett.6b00331
		67087100	189377	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4788206	189377	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5268316	200338	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		90176463	121038	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	528	8	1	4	7.0	CCC1C(C(F)(F)F)=NN(c2ccc(Cc3ccc(-c4cc(OC)ccc4F)cc3C)cc2)C1CC(=O)O	10.1021/ml5002757
		CHEMBL3330549	121038	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	528	8	1	4	7.0	CCC1C(C(F)(F)F)=NN(c2ccc(Cc3ccc(-c4cc(OC)ccc4F)cc3C)cc2)C1CC(=O)O	10.1021/ml5002757
		134137874	159760	0	None	-	0	Rat	4.7	pEC50	=	4.7	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3930086	159760	0	None	-	0	Rat	4.7	pEC50	=	4.7	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3975239	159760	0	None	-	0	Rat	4.7	pEC50	=	4.7	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL5283269	200975	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	502	9	2	8	4.0	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3OC(F)(F)F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5274344	200589	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	492	6	2	7	4.9	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5269158	200372	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	7	2	8	3.9	COc1ccc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc1N1CCCC1=O	10.1021/acsmedchemlett.2c00160
		162656082	187481	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4755578	187481	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL5288493	201209	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	403	5	2	8	3.8	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1C	10.1021/acsmedchemlett.2c00160
		75204360	164396	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	496	7	1	5	5.1	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		CHEMBL4081072	164396	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	496	7	1	5	5.1	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		132606863	164602	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmc.2023.117273
		CHEMBL4083365	164602	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmc.2023.117273
		127037633	144344	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	444	8	1	4	5.7	Cc1cc(F)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754659	144344	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	444	8	1	4	5.7	Cc1cc(F)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		58379893	97081	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	514	7	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2[C@H]2CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385461	97081	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	514	7	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2[C@H]2CCCC2(C)C)c1	10.1021/ml300427u
		71816808	97089	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	500	8	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@]4(C)C[C@H]4C(=O)O)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385472	97089	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	500	8	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@]4(C)C[C@H]4C(=O)O)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		118129979	162573	0	None	-	1	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4059614	162573	0	None	-	1	Rat	6.7	pEC50	=	6.7	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		6483	10658	54	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		66553168	10658	54	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL2386353	10658	54	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL5266488	200262	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	575	13	1	8	5.1	CCOCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		CHEMBL5275101	200617	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	500	9	1	6	5.0	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@](C)(OC)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		15603739	144349	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	460	8	1	4	6.2	Cc1c(Cl)cccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754682	144349	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	460	8	1	4	6.2	Cc1c(Cl)cccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL5275388	200630	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	415	5	2	8	3.7	Cc1ccc(Nc2nc(N)nc(COc3ccc4c5c(c(=O)oc4c3)CCC5)n2)cc1	10.1021/acsmedchemlett.2c00160
		CHEMBL5278703	200769	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.3	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		57705939	118024	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	532	10	1	4	7.9	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2OCCCC2(C)C)c1	10.1021/ml4005123
		CHEMBL3265142	118024	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	532	10	1	4	7.9	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2OCCCC2(C)C)c1	10.1021/ml4005123
		46854655	7183	47	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at FFA1 receptor (unknown origin)Agonist activity at FFA1 receptor (unknown origin)	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmc.2016.09.004
		6485	7183	47	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at FFA1 receptor (unknown origin)Agonist activity at FFA1 receptor (unknown origin)	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmc.2016.09.004
		CHEMBL1829173	7183	47	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at FFA1 receptor (unknown origin)Agonist activity at FFA1 receptor (unknown origin)	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmc.2016.09.004
		68194127	189974	0	None	-	1	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4795763	189974	0	None	-	1	Rat	7.6	pEC50	=	7.6	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5283315	200978	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	532	9	1	5	6.4	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](c5ccccc5)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		127035636	144053	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	490	9	1	6	4.7	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3S(C)(=O)=O)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752168	144053	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	490	9	1	6	4.7	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3S(C)(=O)=O)c2)cc1	10.1016/j.bmcl.2015.11.050
		127036959	144197	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1C	10.1016/j.bmcl.2015.11.050
		CHEMBL3753362	144197	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1C	10.1016/j.bmcl.2015.11.050
		156017123	184522	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	454	9	1	5	5.6	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4OCC)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4642543	184522	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	454	9	1	5	5.6	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4OCC)nc3c2)cc1	10.1016/j.bmc.2020.115574
		51049992	152397	5	None	-	1	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at FFA1 receptor (unknown origin)Agonist activity at FFA1 receptor (unknown origin)	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.bmc.2016.09.004
		CHEMBL3915620	152397	5	None	-	1	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at FFA1 receptor (unknown origin)Agonist activity at FFA1 receptor (unknown origin)	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1016/j.bmc.2016.09.004
		59590895	118032	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	521	9	1	5	6.9	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265150	118032	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	521	9	1	5	6.9	COc1cc(-c2ccc(COc3ccc4c(c3)[C@@](C)(CC(=O)O)CC4)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
		67072752	93304	0	None	-	1	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albuminAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albumin	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
		CHEMBL2315528	93304	0	None	-	1	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albuminAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albumin	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
		CHEMBL5268389	200342	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	423	5	2	8	4.2	Cc1cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)ccc1Cl	10.1021/acsmedchemlett.2c00160
		127036959	144197	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1C	10.1016/j.bmcl.2015.11.050
		CHEMBL3753362	144197	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1C	10.1016/j.bmcl.2015.11.050
		CHEMBL5274396	200593	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	599	11	1	7	6.1	COc1cc(N2CC[C@@H](Oc3ccc(N4C[C@H](OCCCC(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		CHEMBL5289929	201264	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	458	6	2	7	4.5	Cc1ccc(Nc2nc(N)nc(COc3ccc(Cl)c(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		155561358	182433	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	387	7	1	5	4.6	Cc1cccc(-c2nc(C)c(COc3ccc(OCC(=O)O)c(F)c3)s2)c1	10.1016/j.ejmech.2018.12.069
		CHEMBL4581313	182433	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	387	7	1	5	4.6	Cc1cccc(-c2nc(C)c(COc3ccc(OCC(=O)O)c(F)c3)s2)c1	10.1016/j.ejmech.2018.12.069
		90655863	118030	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	516	7	1	5	6.5	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265148	118030	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	516	7	1	5	6.5	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		67087173	189239	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4786335	189239	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		57393692	76802	11	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	438	7	1	2	6.5	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL1939654	76802	11	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	438	7	1	2	6.5	CC#CC(CC(=O)O)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		58380220	118033	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	520	8	1	6	5.9	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265151	118033	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	520	8	1	6	5.9	COc1cc(-c2ccc(COc3cc4c(cn3)CC[C@]43C[C@H]3C(=O)O)cc2[C@H](OC)C(C)(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL5281304	200888	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	522	10	1	6	5.2	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](OC(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5274496	200600	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	524	7	1	5	5.6	COc1ccc(F)c(N2C[C@@H](C)[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@@H](C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5267671	200314	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	446	8	2	7	3.7	Cc1cc(OCc2nc(N)nc(NCCc3c(C)cccc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5287009	201150	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	418	8	2	7	3.1	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		155569735	183455	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	371	7	1	4	4.9	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4535460	183455	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	371	7	1	4	4.9	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4598257	183455	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	371	7	1	4	4.9	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		145965707	170982	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4210871	170982	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	421	7	1	6	3.7	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		162676686	190265	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4799453	190265	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		6483	10658	54	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albuminAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albumin	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		66553168	10658	54	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albuminAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albumin	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL2386353	10658	54	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albuminAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay in presence of bovine serum albumin	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL5272492	200506	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	403	6	2	8	3.8	CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		24857286	8405	72	None	-10	2	Rat	4.6	pEC50	=	4.6	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		6484	8405	72	None	-10	2	Rat	4.6	pEC50	=	4.6	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		CHEMBL1829174	8405	72	None	-10	2	Rat	4.6	pEC50	=	4.6	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		DB12491	8405	72	None	-10	2	Rat	4.6	pEC50	=	4.6	Binding	Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAAgonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.6b00331
		1050	8683	94	None	1	2	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.6b00202
		11595431	8683	94	None	1	2	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.6b00202
		CHEMBL207881	8683	94	None	1	2	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.6b00202
		90655862	118028	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	492	9	1	5	6.7	COc1cc(-c2ccc(COc3cc([C@H](C)CC(=O)O)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3265146	118028	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	492	9	1	5	6.7	COc1cc(-c2ccc(COc3cc([C@H](C)CC(=O)O)ccn3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		156635003	187715	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4758125	187715	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		11961321	118576	4	None	-	0	Crab-eating macaque	7.5	pEC50	=	7.5	Binding	Agonist activity at cynomolgus monkey GPR40 in presence of 0.01% human serum albumin relative to AMG 837Agonist activity at cynomolgus monkey GPR40 in presence of 0.01% human serum albumin relative to AMG 837	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3287569	118576	4	None	-	0	Crab-eating macaque	7.5	pEC50	=	7.5	Binding	Agonist activity at cynomolgus monkey GPR40 in presence of 0.01% human serum albumin relative to AMG 837Agonist activity at cynomolgus monkey GPR40 in presence of 0.01% human serum albumin relative to AMG 837	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL5283236	200972	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	491	7	1	6	4.7	COc1cc(N2CC[C@@H](Oc3ccc(N4C[C@H](F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		134139990	153106	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	461	10	1	4	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)=O)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3921143	153106	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	461	10	1	4	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)=O)c2)cc1	10.1021/acsmedchemlett.6b00331
		75204006	121037	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	484	7	1	5	6.4	COc1cccc(-c2ccc(Oc3ccc(N4N=C(C(F)(F)F)CC4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		CHEMBL3330548	121037	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	484	7	1	5	6.4	COc1cccc(-c2ccc(Oc3ccc(N4N=C(C(F)(F)F)CC4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		CHEMBL5282578	200941	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	552	9	1	5	6.4	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](C(C)C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5279836	200819	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	417	7	2	8	4.1	CCCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		127035669	144095	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	440	8	1	4	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752601	144095	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	440	8	1	4	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		71257551	157372	24	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3955132	157372	24	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.6b00892
		162664735	188865	0	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4781604	188865	0	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5075693	221169	3	None	-	1	Human	8.5	pEC50	=	8.5	Binding	IPOne assayIPOne assay	ChEMBL		None	None	None		Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O	10.6019/CHEMBL5058643
		46854655	7183	47	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		6485	7183	47	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		CHEMBL1829173	7183	47	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		51357276	188786	0	None	-	1	Mouse	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4780641	188786	0	None	-	1	Mouse	8.5	pEC50	=	8.5	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		67087041	189150	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4785057	189150	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162674654	190234	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798993	190234	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		134465794	177857	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assayAgonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
		CHEMBL4457303	177857	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assayAgonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assay	ChEMBL	458	9	1	3	6.5	COc1ccc(F)c([C@H]2CC[C@H](COc3cccc([C@H](C4CC4)[C@@](C)(F)C(=O)O)c3)CC2)c1	10.1021/acsmedchemlett.8b00444
		68194237	188985	0	None	-	1	Mouse	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4783033	188985	0	None	-	1	Mouse	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		68194449	189593	0	None	-	1	Mouse	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4790921	189593	0	None	-	1	Mouse	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		68194465	190085	0	None	-	1	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797124	190085	0	None	-	1	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		118129999	164546	0	None	-	1	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4082711	164546	0	None	-	1	Rat	7.5	pEC50	=	7.5	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL5277813	200731	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	541	7	1	6	5.5	COc1cc(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		90159227	164846	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	514	7	1	4	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmc.2023.117273
		CHEMBL4086198	164846	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	514	7	1	4	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5275546	200640	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3c(F)cccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5278836	200778	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	452	8	2	7	3.8	Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5280494	200849	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	450	8	2	7	3.6	Cc1cc(OCc2nc(N)nc(NCCc3cc(C)ccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5282108	200924	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		90655859	117992	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	461	10	1	4	7.0	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cncc(OC)c3)c(C(C)(C)C)c2)c1	10.1021/ml4005123
		CHEMBL3264818	117992	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	461	10	1	4	7.0	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cncc(OC)c3)c(C(C)(C)C)c2)c1	10.1021/ml4005123
		127036829	144085	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	480	8	1	4	6.6	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccc(Cl)cc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752487	144085	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	480	8	1	4	6.6	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccc(Cl)cc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		118129981	166246	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4101472	166246	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		162645828	186442	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4743323	186442	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
		162652317	187100	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4751137	187100	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL5284113	201023	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	575	12	1	8	5.1	COCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)C1(C)C	10.1016/j.bmc.2023.117273
		156013152	184257	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	7	1	4	5.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C)cc4C)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4639182	184257	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	7	1	4	5.8	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C)cc4C)cn3c2)cc1	10.1016/j.bmc.2020.115574
		1050	8683	94	None	1	2	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.07.043
		11595431	8683	94	None	1	2	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.07.043
		CHEMBL207881	8683	94	None	1	2	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationAgonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2014.07.043
		CHEMBL5289099	201239	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	425	6	2	8	4.1	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C(F)F)cc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
		CHEMBL5286632	201132	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	492	6	2	7	4.9	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)cc(C(F)(F)F)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		58230552	188998	0	None	-	1	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4783190	188998	0	None	-	1	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		132606864	164525	0	None	-	1	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayAgonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL4082395	164525	0	None	-	1	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayAgonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL5284884	201048	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	544	9	2	7	5.8	Cc1cc(OCc2nc(N)nc(NCCc3cccc(S(F)(F)(F)(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		6483	10658	54	None	-	1	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused rat FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused rat FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		66553168	10658	54	None	-	1	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused rat FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused rat FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL2386353	10658	54	None	-	1	Rat	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused rat FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused rat FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL5267399	200306	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	409	5	2	8	3.8	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		9823501	106983	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	421	7	1	4	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL288341	106983	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	421	7	1	4	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4445519	106983	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	421	7	1	4	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		11961321	118576	4	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1021/ml400501x
		CHEMBL3287569	118576	4	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1021/ml400501x
		15603842	118577	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	461	8	1	5	5.6	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3ncnn3C)cc2)c1	10.1021/ml400501x
		CHEMBL3287570	118577	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	461	8	1	5	5.6	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3ncnn3C)cc2)c1	10.1021/ml400501x
		11961321	118576	4	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3287569	118576	4	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		132606863	164602	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayAgonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL4083365	164602	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayAgonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assay	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		68674201	144067	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	476	8	1	2	7.6	O=C(O)CC(c1ccccc1)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752303	144067	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	476	8	1	2	7.6	O=C(O)CC(c1ccccc1)c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		127035471	144269	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	477	8	1	3	7.0	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1ccccn1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753980	144269	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	477	8	1	3	7.0	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1ccccn1	10.1016/j.bmcl.2015.11.050
		CHEMBL5281020	200875	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		57522038	10659	60	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
		6490	10659	60	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
		CHEMBL2058533	10659	60	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
		58230552	188998	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4783190	188998	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL5287358	201160	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	448	9	2	8	3.1	COc1ccccc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1	10.1021/acsmedchemlett.2c00160
		67361692	97073	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	540	7	1	3	8.4	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CCC4)CC[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385303	97073	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	540	7	1	3	8.4	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CCC4)CC[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		24857286	8405	72	None	-10	2	Rat	7.4	pEC50	=	7.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		6484	8405	72	None	-10	2	Rat	7.4	pEC50	=	7.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		CHEMBL1829174	8405	72	None	-10	2	Rat	7.4	pEC50	=	7.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		DB12491	8405	72	None	-10	2	Rat	7.4	pEC50	=	7.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		90644561	118575	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	418	7	1	2	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccc(Cl)cc3C)c2)cc1	10.1021/ml400501x
		CHEMBL3287568	118575	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	418	7	1	2	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccc(Cl)cc3C)c2)cc1	10.1021/ml400501x
		24897670	118581	23	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ccon2)cc1	10.1021/ml400501x
		CHEMBL3287574	118581	23	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ccon2)cc1	10.1021/ml400501x
		162667620	189336	0	None	-	1	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4787628	189336	0	None	-	1	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		127036828	144215	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	444	8	1	4	5.7	Cc1ccc(F)cc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753533	144215	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	444	8	1	4	5.7	Cc1ccc(F)cc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		76900387	164324	6	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	540	7	1	7	5.3	COc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		CHEMBL4080226	164324	6	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationPositive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	540	7	1	7	5.3	COc1cc(N2CC[C@@H](Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		90158812	121036	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	335	5	1	5	3.7	Cc1ccccc1Oc1ccc(N2N=C(C#N)CC2CC(=O)O)cc1	10.1021/ml5002757
		CHEMBL3330547	121036	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	335	5	1	5	3.7	Cc1ccccc1Oc1ccc(N2N=C(C#N)CC2CC(=O)O)cc1	10.1021/ml5002757
		57706032	118020	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	460	10	1	3	7.6	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cccc(OC)c3)c(C(C)(C)C)c2)c1	10.1021/ml4005123
		CHEMBL3265138	118020	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	460	10	1	3	7.6	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cccc(OC)c3)c(C(C)(C)C)c2)c1	10.1021/ml4005123
		145965467	170945	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	403	7	1	6	3.6	Cc1nc(-c2ccccc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4210415	170945	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	403	7	1	6	3.6	Cc1nc(-c2ccccc2)sc1COc1ccc(S(=O)(=O)CC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL5275951	200658	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	524	7	1	5	5.8	COc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)C(C)(C)C2)c1	10.1016/j.bmc.2023.117273
		90655858	118019	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	461	10	1	4	7.0	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cccc(OC)n3)c(C(C)(C)C)c2)c1	10.1021/ml4005123
		CHEMBL3265137	118019	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	461	10	1	4	7.0	CCC[C@H](CC(=O)O)c1cccc(OCc2ccc(-c3cccc(OC)n3)c(C(C)(C)C)c2)c1	10.1021/ml4005123
		155512244	176408	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	373	7	1	5	4.3	Cc1nc(-c2ccccc2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		CHEMBL4436948	176408	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	373	7	1	5	4.3	Cc1nc(-c2ccccc2)sc1COc1ccc(OCC(=O)O)c(F)c1	10.1016/j.ejmech.2018.12.069
		70901463	97086	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	512	7	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@@]3(CC4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385467	97086	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	512	7	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@@]3(CC4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		134136203	149749	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	433	10	1	4	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(C)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3894356	149749	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	433	10	1	4	5.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(C)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		162644059	188603	0	None	-	1	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		CHEMBL4778264	188603	0	None	-	1	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		156020437	184927	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4C)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4648853	184927	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4C)cn3c2)cc1	10.1016/j.bmc.2020.115574
		67072752	93304	0	None	-	1	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse FFA1Agonist activity at mouse FFA1	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
		CHEMBL2315528	93304	0	None	-	1	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse FFA1Agonist activity at mouse FFA1	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
		89671280	153466	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	406	5	3	3	4.1	CC#C[C@@H](CC(=O)O)c1ccc(NC(=O)C(=O)Nc2cccc(C(C)(C)C)c2)cc1	10.1016/j.bmc.2017.03.001
		CHEMBL3923877	153466	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at FFA1 (unknown origin)Agonist activity at FFA1 (unknown origin)	ChEMBL	406	5	3	3	4.1	CC#C[C@@H](CC(=O)O)c1ccc(NC(=O)C(=O)Nc2cccc(C(C)(C)C)c2)cc1	10.1016/j.bmc.2017.03.001
		68194476	189666	0	None	-	1	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792075	189666	0	None	-	1	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		134140675	153557	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	509	12	1	4	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccccc3)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3924534	153557	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	509	12	1	4	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccccc3)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		162676686	190265	0	None	-	1	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4799453	190265	0	None	-	1	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		67087173	189239	0	None	-	1	Rat	8.3	pEC50	=	8.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4786335	189239	0	None	-	1	Rat	8.3	pEC50	=	8.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		134147518	156896	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	487	11	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3951157	156896	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	487	11	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		59132740	144148	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	477	8	1	3	7.0	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1cccnc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753057	144148	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis	ChEMBL	477	8	1	3	7.0	O=C(O)CC(c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1)c1cccnc1	10.1016/j.bmcl.2015.11.050
		CHEMBL5266730	200269	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)cc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		15602772	118580	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	503	8	1	8	4.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nnnn2C)cc1	10.1021/ml400501x
		CHEMBL3287573	118580	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	503	8	1	8	4.8	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nnnn2C)cc1	10.1021/ml400501x
		127035638	144247	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	442	9	1	5	5.3	COc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753790	144247	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	442	9	1	5	5.3	COc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL5290988	201297	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Positive allosteric modulation of human GPR40 expressed in HEK293 cellsPositive allosteric modulation of human GPR40 expressed in HEK293 cells	ChEMBL	428	7	1	5	4.3	COc1ccc(F)c(N2CCC(Oc3ccc(N4CCC[C@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		156010854	183898	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	492	8	1	4	7.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C5CCCCC5)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4633642	183898	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	492	8	1	4	7.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C5CCCCC5)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL5283217	200970	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	449	6	2	8	3.7	Cc1ccc(Nc2nc(N)nc(COc3cc(C#N)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		162666840	189233	0	None	-	1	Rat	6.4	pEC50	=	6.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4786299	189233	0	None	-	1	Rat	6.4	pEC50	=	6.4	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		127036828	144215	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	444	8	1	4	5.7	Cc1ccc(F)cc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753533	144215	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	444	8	1	4	5.7	Cc1ccc(F)cc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		127035667	144064	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	446	8	1	4	5.9	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752274	144064	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	446	8	1	4	5.9	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		127037608	144177	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	426	8	1	4	5.6	Cc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753265	144177	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	426	8	1	4	5.6	Cc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL5268183	200330	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	538	9	1	5	6.1	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](CC)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5280786	200862	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	566	10	1	5	6.8	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](CC(C)C)C2)c1	10.1016/j.bmc.2023.117273
		127036747	144347	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	442	9	1	5	5.3	COc1ccc(-c2cccc(COc3ccc([C@H](CC(=O)O)c4nccn4C)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754670	144347	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	442	9	1	5	5.3	COc1ccc(-c2cccc(COc3ccc([C@H](CC(=O)O)c4nccn4C)cc3)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL5285104	201058	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)cc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		118129979	162573	0	None	-	1	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4059614	162573	0	None	-	1	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		24857286	8405	72	None	10	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.12.069
		6484	8405	72	None	10	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.12.069
		CHEMBL1829174	8405	72	None	10	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.12.069
		DB12491	8405	72	None	10	2	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.ejmech.2018.12.069
		CHEMBL5268798	200357	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	534	10	1	6	5.8	CCOc1ccc(F)c(N2CCC(Oc3ccc(N4C[C@H](Oc5ccccc5)C[C@@H]4CC(=O)O)cc3)CC2)c1	10.1016/j.bmc.2023.117273
		156016183	184447	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4C)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4641652	184447	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4C)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL5276740	200692	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	417	6	2	8	4.3	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		156013404	184238	3	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	440	8	1	5	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4638956	184238	3	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	440	8	1	5	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		1050	8683	94	None	1	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
		11595431	8683	94	None	1	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
		CHEMBL207881	8683	94	None	1	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
		127035668	144117	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	440	9	1	4	5.8	CCc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752807	144117	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	440	9	1	4	5.8	CCc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL5283236	200972	0	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Positive allosteric modulation of mouse GPR40Positive allosteric modulation of mouse GPR40	ChEMBL	491	7	1	6	4.7	COc1cc(N2CC[C@@H](Oc3ccc(N4C[C@H](F)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c(Cl)cn1	10.1016/j.bmc.2023.117273
		CHEMBL5273852	200561	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	478	8	2	7	4.3	Cc1cc(OCc2nc(N)nc(NCC3(c4cccc(Cl)c4)CC3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		837245	17371	46	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL1170012	17371	46	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL5285988	201104	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	561	12	1	8	4.8	COCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		156019672	184769	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	8	1	4	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(CC)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4646212	184769	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	8	1	4	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(CC)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		52936292	188889	27	None	-	1	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4782004	188889	27	None	-	1	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		51357276	188786	0	None	-	1	Rat	8.3	pEC50	=	8.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4780641	188786	0	None	-	1	Rat	8.3	pEC50	=	8.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162667620	189336	0	None	-	1	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4787628	189336	0	None	-	1	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL5271268	200456	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at FFAR1 (unknown origin) incubated for 16 hrs by Promoter-luciferase assayAgonist activity at FFAR1 (unknown origin) incubated for 16 hrs by Promoter-luciferase assay	ChEMBL	470	9	1	5	5.3	CC#CC(CC(=O)O)c1ccc(OCc2cccc(CN3CCc4oc(C5CC5)nc4C3)c2)cc1	10.1016/j.ejmech.2018.04.061
		44223813	97093	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	500	8	1	3	7.8	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@@H](CC(=O)O)CC4)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385476	97093	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	500	8	1	3	7.8	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@@H](CC(=O)O)CC4)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL5266523	200264	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	484	10	2	8	3.7	Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5267225	200292	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	436	8	2	7	3.3	Cc1cc(OCc2nc(N)nc(NCCc3cccc(F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		156013456	184254	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	7	1	4	5.8	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C)cc4C)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4639121	184254	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	7	1	4	5.8	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C)cc4C)nc3c2)cc1	10.1016/j.bmc.2020.115574
		156019224	184750	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4645989	184750	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL5281753	200903	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	558	13	1	7	5.2	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](OCCCOC)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		67359903	97091	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	526	7	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)CC[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385474	97091	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	526	7	1	3	8.0	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)CC[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		68194159	189840	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4794233	189840	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		156012263	184073	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	452	8	1	4	6.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4636540	184073	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	452	8	1	4	6.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		24857286	8405	72	None	10	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2020.115574
		6484	8405	72	None	10	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2020.115574
		CHEMBL1829174	8405	72	None	10	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2020.115574
		DB12491	8405	72	None	10	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmc.2020.115574
		3367	7939	1	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/acs.jmedchem.6b00202
		46216676	7939	1	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/acs.jmedchem.6b00202
		CHEMBL604126	7939	1	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/acs.jmedchem.6b00202
		58230598	189898	0	None	-	1	Rat	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		CHEMBL4794904	189898	0	None	-	1	Rat	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		132578495	189665	2	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792027	189665	2	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5283683	201004	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	482	9	2	8	3.8	COc1ccc(Cl)cc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1	10.1021/acsmedchemlett.2c00160
		561372	65601	65	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/acs.jmedchem.6b00202
		CHEMBL1688452	65601	65	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/acs.jmedchem.6b00202
		156014759	184031	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	478	7	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(F)(F)F)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4635975	184031	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	478	7	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(F)(F)F)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		156011495	184133	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	492	8	1	4	7.2	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C5CCCCC5)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4637557	184133	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	492	8	1	4	7.2	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C5CCCCC5)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		51357276	188786	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4780641	188786	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		90158812	121036	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	335	5	1	5	3.7	Cc1ccccc1Oc1ccc(N2N=C(C#N)CC2CC(=O)O)cc1	10.1021/ml5002757
		CHEMBL3330547	121036	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	335	5	1	5	3.7	Cc1ccccc1Oc1ccc(N2N=C(C#N)CC2CC(=O)O)cc1	10.1021/ml5002757
		127035667	144064	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	446	8	1	4	5.9	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752274	144064	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	446	8	1	4	5.9	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		118129998	164102	0	None	-	1	Rat	6.3	pEC50	=	6.3	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4077366	164102	0	None	-	1	Rat	6.3	pEC50	=	6.3	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		162673626	189972	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4795755	189972	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		90644562	118583	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2cnco2)cc1	10.1021/ml400501x
		CHEMBL3287576	118583	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2cnco2)cc1	10.1021/ml400501x
		68194237	188985	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4783033	188985	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		127035669	144095	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	440	8	1	4	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752601	144095	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	440	8	1	4	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL5269274	200375	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	500	9	1	6	4.8	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](OC)[C@@H](C)[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5289252	201242	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	510	7	1	5	5.4	COc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@@H](C)C2)c1	10.1016/j.bmc.2023.117273
		156013517	184289	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4F)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4639658	184289	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4F)cn3c2)cc1	10.1016/j.bmc.2020.115574
		127037633	144344	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	444	8	1	4	5.7	Cc1cc(F)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754659	144344	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	444	8	1	4	5.7	Cc1cc(F)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		155569722	183037	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	353	7	1	4	4.7	Cc1nc(-c2ccccc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4528449	183037	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	353	7	1	4	4.7	Cc1nc(-c2ccccc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL4594952	183037	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	353	7	1	4	4.7	Cc1nc(-c2ccccc2)sc1COc1ccc(CCC(=O)O)cc1	10.1016/j.ejmech.2018.12.069
		156021563	184804	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR40 expressed in HEK293 cells incubated for 1 hrs by calcium flux assayAgonist activity at human GPR40 expressed in HEK293 cells incubated for 1 hrs by calcium flux assay	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.ejmech.2018.04.061
		CHEMBL4646784	184804	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR40 expressed in HEK293 cells incubated for 1 hrs by calcium flux assayAgonist activity at human GPR40 expressed in HEK293 cells incubated for 1 hrs by calcium flux assay	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.ejmech.2018.04.061
		73891117	121040	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	522	8	1	4	7.1	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(c5ccccc5)C(C)C4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		CHEMBL3330550	121040	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	522	8	1	4	7.1	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(c5ccccc5)C(C)C4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		132578495	189665	2	None	-	1	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792027	189665	2	None	-	1	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		46854655	7183	47	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml300427u
		6485	7183	47	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml300427u
		CHEMBL1829173	7183	47	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/ml300427u
		CHEMBL5286544	201129	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	457	5	2	8	4.8	Cc1c(Cl)cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		162644059	188603	0	None	-	1	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		CHEMBL4778264	188603	0	None	-	1	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		CHEMBL5268800	200358	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	452	8	2	7	3.8	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5283726	201006	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.3	Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		15603739	144349	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	460	8	1	4	6.2	Cc1c(Cl)cccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754682	144349	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	460	8	1	4	6.2	Cc1c(Cl)cccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		67072752	93304	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.6b00202
		CHEMBL2315528	93304	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.6b00202
		CHEMBL5271725	200473	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	478	8	2	7	4.3	Cc1cc(OCc2nc(N)nc(NC3(Cc4cccc(Cl)c4)CC3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		127036748	144295	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	496	9	1	5	6.2	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754173	144295	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	496	9	1	5	6.2	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2015.11.050
		156019823	184718	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	452	8	1	4	6.3	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C(C)C)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4645557	184718	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	452	8	1	4	6.3	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C(C)C)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		156016011	184386	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4640818	184386	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	424	7	1	4	5.5	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		68194476	189666	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792075	189666	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		137633536	163074	0	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA1 receptorAgonist activity at mouse FFA1 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
		CHEMBL4065397	163074	0	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA1 receptorAgonist activity at mouse FFA1 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
		156010092	183886	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(F)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4633473	183886	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(F)cc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL5290818	201291	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	545	11	1	7	5.5	CCCCO[C@H]1CN(c2ccc(O[C@@H]3CCN(c4cc(OC)ncc4Cl)C[C@H]3C)cc2)[C@@H](CC(=O)O)[C@@H]1C	10.1016/j.bmc.2023.117273
		156019930	184741	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	446	7	1	4	5.4	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4cc(F)ccc4F)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4645938	184741	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	446	7	1	4	5.4	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4cc(F)ccc4F)nc3c2)cc1	10.1016/j.bmc.2020.115574
		11961321	118576	4	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat GPR40 in presence of 0.01% human serum albuminAgonist activity at rat GPR40 in presence of 0.01% human serum albumin	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3287569	118576	4	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Agonist activity at rat GPR40 in presence of 0.01% human serum albuminAgonist activity at rat GPR40 in presence of 0.01% human serum albumin	ChEMBL	460	8	1	4	6.2	Cc1cc(Cl)ccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		73891117	121040	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	522	8	1	4	7.1	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(c5ccccc5)C(C)C4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		CHEMBL3330550	121040	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Modulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assayModulation activity at human GPR40 expressed in HEK293 cells by IP-1 detection based HTRF assay	ChEMBL	522	8	1	4	7.1	COc1ccc(F)c(-c2ccc(Cc3ccc(N4N=C(c5ccccc5)C(C)C4CC(=O)O)cc3)c(C)c2)c1	10.1021/ml5002757
		23083113	184231	6	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	306	6	1	2	4.4	O=C(O)CCc1ccc(OCc2cccc3ccccc23)cc1	10.1016/j.bmc.2019.115263
		CHEMBL4638816	184231	6	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	306	6	1	2	4.4	O=C(O)CCc1ccc(OCc2cccc3ccccc23)cc1	10.1016/j.bmc.2019.115263
		15603947	118579	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	502	8	1	7	5.5	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ncnn2C)cc1	10.1021/ml400501x
		CHEMBL3287572	118579	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	502	8	1	7	5.5	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ncnn2C)cc1	10.1021/ml400501x
		8852666	199461	26	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1ccccc1Nc1nc(N)nc(COc2ccc3c(C)cc(=O)oc3c2)n1	10.1021/acsmedchemlett.2c00160
		CHEMBL5219102	199461	26	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1ccccc1Nc1nc(N)nc(COc2ccc3c(C)cc(=O)oc3c2)n1	10.1021/acsmedchemlett.2c00160
		127035668	144117	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	440	9	1	4	5.8	CCc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752807	144117	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	440	9	1	4	5.8	CCc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		118129999	164546	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4082711	164546	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		25150014	10657	55	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/acs.jmedchem.6b00202
		3952	10657	55	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/acs.jmedchem.6b00202
		CHEMBL449588	10657	55	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/acs.jmedchem.6b00202
		156017576	184618	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	8	1	4	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(CC)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4644067	184618	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	438	8	1	4	5.7	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(CC)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		156021586	184859	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	478	7	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C(F)(F)F)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4647663	184859	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	478	7	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(C(F)(F)F)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		162674533	190244	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4799103	190244	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assayAgonist activity at human FFA1 receptor expressed in CHO-K1 cells assessed as increase in dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		57706227	117989	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	517	10	1	4	7.7	COc1cc(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3264815	117989	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	517	10	1	4	7.7	COc1cc(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		155565451	182374	11	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OC[C@H]2CC(=O)O	10.1016/j.ejmech.2018.12.069
		CHEMBL4579901	182374	11	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	449	6	1	5	5.7	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(c1)OC[C@H]2CC(=O)O	10.1016/j.ejmech.2018.12.069
		118129981	166246	0	None	-	1	Rat	7.2	pEC50	=	7.2	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4101472	166246	0	None	-	1	Rat	7.2	pEC50	=	7.2	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		162666840	189233	0	None	-	1	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4786299	189233	0	None	-	1	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		118129998	164102	0	None	-	1	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4077366	164102	0	None	-	1	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		15604434	118582	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ncco2)cc1	10.1021/ml400501x
		CHEMBL3287575	118582	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	488	8	1	6	6.3	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ncco2)cc1	10.1021/ml400501x
		127036829	144085	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	480	8	1	4	6.6	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccc(Cl)cc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3752487	144085	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	480	8	1	4	6.6	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccc(Cl)cc3Cl)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL5268534	200348	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	510	7	1	5	5.4	COc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](C)C2)c1	10.1016/j.bmc.2023.117273
		67072752	93304	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
		CHEMBL2315528	93304	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA1 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
		127035637	144033	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	437	8	1	5	5.1	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3C#N)c2)cc1	10.1016/j.bmcl.2015.11.050
		CHEMBL3751968	144033	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	437	8	1	5	5.1	Cn1ccnc1[C@@H](CC(=O)O)c1ccc(OCc2cccc(-c3ccccc3C#N)c2)cc1	10.1016/j.bmcl.2015.11.050
		134139119	152764	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	511	12	1	5	5.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)S(=O)(=O)CC)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3918387	152764	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	511	12	1	5	5.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)S(=O)(=O)CC)c2)cc1	10.1021/acsmedchemlett.6b00331
		71257551	157372	24	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3955132	157372	24	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.6b00892
		68194127	189974	0	None	-	1	Mouse	8.1	pEC50	=	8.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4795763	189974	0	None	-	1	Mouse	8.1	pEC50	=	8.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		24857286	8405	72	None	10	2	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.2c00160
		6484	8405	72	None	10	2	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.2c00160
		CHEMBL1829174	8405	72	None	10	2	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.2c00160
		DB12491	8405	72	None	10	2	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at FFAR1 (unknown origin)Agonist activity at FFAR1 (unknown origin)	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acsmedchemlett.2c00160
		134142245	152278	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	503	11	1	5	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCOCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3914686	152278	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	503	11	1	5	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCOCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		134142149	152246	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	519	11	1	5	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCSCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3914418	152246	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	519	11	1	5	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C3CCSCC3)c2)cc1	10.1021/acsmedchemlett.6b00331
		68194743	189327	12	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787498	189327	12	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL5267168	200290	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	415	6	2	8	4.1	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C5CC5)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		CHEMBL5283407	200985	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	425	5	2	8	4.3	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc5ccccc5c4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		CHEMBL5279649	200812	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	432	8	2	7	3.4	Cc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5289306	201243	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		156016727	184497	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4F)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4642297	184497	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccccc4F)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL5280836	200866	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR40 expressed in HEK293 cells incubated for 18 to 24 hrs by HTRF assayAgonist activity at human GPR40 expressed in HEK293 cells incubated for 18 to 24 hrs by HTRF assay	ChEMBL	541	7	2	8	3.9	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)[C@H](N)C2)c(Cl)cn1	10.1016/j.ejmech.2018.04.061
		156016929	184504	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR40 (unknown origin)Modulation of GPR40 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
		CHEMBL4642324	184504	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR40 (unknown origin)Modulation of GPR40 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
		CHEMBL5285725	201090	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	446	8	2	7	3.7	Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)cc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		15603946	118435	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	501	8	1	6	6.1	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nccn2C)cc1	10.1021/ml400501x
		CHEMBL3286409	118435	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR40 expressed in CHO cells by aequorin assayAgonist activity at human GPR40 expressed in CHO cells by aequorin assay	ChEMBL	501	8	1	6	6.1	Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2nccn2C)cc1	10.1021/ml400501x
		58230598	189898	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		CHEMBL4794904	189898	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		CHEMBL5267340	200300	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	600	10	1	5	7.0	CCOc1ccc(F)c(N2CC[C@@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@H](Cc3ccccc3)C2)c1	10.1016/j.bmc.2023.117273
		CHEMBL5286962	201145	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		23136411	65606	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.bmc.2019.115263
		CHEMBL1688457	65606	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1016/j.bmc.2019.115263
		127035639	144333	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	442	9	1	5	5.3	COc1cccc(-c2cccc(COc3ccc([C@H](CC(=O)O)c4nccn4C)cc3)c2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3754524	144333	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	442	9	1	5	5.3	COc1cccc(-c2cccc(COc3ccc([C@H](CC(=O)O)c4nccn4C)cc3)c2)c1	10.1016/j.bmcl.2015.11.050
		57705880	117990	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml4005123
		CHEMBL3264816	117990	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	516	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml4005123
		71575419	96747	0	None	-	0	Rat	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretionAgonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
		CHEMBL2381282	96747	0	None	-	0	Rat	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretionAgonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion	ChEMBL	390	3	1	4	3.9	O=C(O)C[C@@H]1COc2cc3c(cc21)OC[C@@H](c1cccc(Br)c1)O3	10.1016/j.bmcl.2013.03.060
		8852666	199461	26	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulation of GPR40 (unknown origin)Positive allosteric modulation of GPR40 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1ccccc1Nc1nc(N)nc(COc2ccc3c(C)cc(=O)oc3c2)n1	10.1016/j.ejmech.2022.114645
		CHEMBL5219102	199461	26	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulation of GPR40 (unknown origin)Positive allosteric modulation of GPR40 (unknown origin)	ChEMBL	389	5	2	8	3.5	Cc1ccccc1Nc1nc(N)nc(COc2ccc3c(C)cc(=O)oc3c2)n1	10.1016/j.ejmech.2022.114645
		CHEMBL5278642	200767	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	443	5	2	8	4.5	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)c(Cl)c4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		CHEMBL5268155	200328	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	407	6	2	8	3.2	Cc1cc(=O)oc2cc(OCc3nc(N)nc(NCc4ccc(F)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		156011880	184109	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(F)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4637214	184109	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	428	7	1	4	5.3	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(F)cc4)nc3c2)cc1	10.1016/j.bmc.2020.115574
		127034370	145619	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	399	6	1	5	4.8	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		CHEMBL3781477	145619	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	399	6	1	5	4.8	Cc1nc(-c2ccc(F)cc2)sc1COc1ccc2c(c1)OCC2CC(=O)O	10.1016/j.ejmech.2018.12.069
		57705648	97092	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	474	9	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385475	97092	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	474	9	1	3	7.3	COc1ccc(F)c(-c2ccc(COc3cccc(CCC(=O)O)c3)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		156016232	184551	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	446	7	1	4	5.4	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(F)cc4F)nc3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4642960	184551	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	446	7	1	4	5.4	CC#CC(CC(=O)O)c1ccc(OCc2ccn3cc(-c4ccc(F)cc4F)nc3c2)cc1	10.1016/j.bmc.2020.115574
		3893	9067	98	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
		4642	9067	98	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
		5534	9067	98	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
		CHEMBL108766	9067	98	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
		DB03017	9067	98	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1021/acs.jmedchem.6b00202
		156009878	183903	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	281	6	1	3	3.2	N#Cc1ccccc1COc1ccc(CCC(=O)O)cc1	10.1016/j.bmc.2019.115263
		CHEMBL4633698	183903	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	281	6	1	3	3.2	N#Cc1ccccc1COc1ccc(CCC(=O)O)cc1	10.1016/j.bmc.2019.115263
		162676881	190364	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4800563	190364	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		24857286	8405	72	None	-	2	Mouse	8.1	pEC50	=	8.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		6484	8405	72	None	-	2	Mouse	8.1	pEC50	=	8.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		CHEMBL1829174	8405	72	None	-	2	Mouse	8.1	pEC50	=	8.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		DB12491	8405	72	None	-	2	Mouse	8.1	pEC50	=	8.1	Binding	Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		134143418	152111	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	477	13	1	5	5.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(CCOC)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3913383	152111	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	477	13	1	5	5.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(CCOC)Cc3ccsc3)c2)cc1	10.1021/acsmedchemlett.6b00331
		134137874	159760	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3930086	159760	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		CHEMBL3975239	159760	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayAgonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay	ChEMBL	461	11	1	4	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1	10.1021/acsmedchemlett.6b00331
		51049992	152397	5	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3915620	152397	5	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		46854655	7183	47	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		6485	7183	47	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		CHEMBL1829173	7183	47	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		45254027	97080	10	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	514	7	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385460	97080	10	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	514	7	1	3	7.7	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL5278718	200771	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	424	6	2	7	3.9	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		58380284	97078	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	498	7	1	3	7.2	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(C4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385459	97078	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	498	7	1	3	7.2	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(C4)C[C@H]3C(=O)O)cc2C2=CCCC2(C)C)c1	10.1021/ml300427u
		156021515	184917	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	446	7	1	4	5.4	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(F)cc4F)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4648621	184917	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	446	7	1	4	5.4	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(F)cc4F)cn3c2)cc1	10.1016/j.bmc.2020.115574
		68194127	189974	0	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4795763	189974	0	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		57706902	117987	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	490	10	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2CC(C)(C)C)c1	10.1021/ml4005123
		CHEMBL3264813	117987	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	490	10	1	3	7.6	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2CC(C)(C)C)c1	10.1021/ml4005123
		46854655	7183	47	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		6485	7183	47	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		CHEMBL1829173	7183	47	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1016/j.bmcl.2015.11.050
		127037608	144177	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	426	8	1	4	5.6	Cc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		CHEMBL3753265	144177	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	426	8	1	4	5.6	Cc1ccccc1-c1cccc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)c1	10.1016/j.bmcl.2015.11.050
		162674998	190170	0	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798023	190170	0	None	-	1	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		24857286	8405	72	None	10	2	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		6484	8405	72	None	10	2	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		CHEMBL1829174	8405	72	None	10	2	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		DB12491	8405	72	None	10	2	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assayAgonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		58380255	97082	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	528	7	1	3	8.1	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CCC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385462	97082	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	528	7	1	3	8.1	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3)[C@]3(CCC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml300427u
		57707110	117988	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	535	10	1	4	7.9	COc1cc(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3F)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		CHEMBL3264814	117988	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albuminAgonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0.01% human serum albumin	ChEMBL	535	10	1	4	7.9	COc1cc(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3F)cc2[C@@H]2CCCC2(C)C)c(F)cn1	10.1021/ml4005123
		24857286	8405	72	None	-10	2	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretionAgonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
		6484	8405	72	None	-10	2	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretionAgonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
		CHEMBL1829174	8405	72	None	-10	2	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretionAgonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
		DB12491	8405	72	None	-10	2	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretionAgonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1016/j.bmcl.2013.03.060
		127033818	145525	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	395	6	1	5	5.0	Cc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2018.12.069
		CHEMBL3780334	145525	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayAgonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay	ChEMBL	395	6	1	5	5.0	Cc1ccc(-c2nc(C)c(COc3ccc4c(c3)OCC4CC(=O)O)s2)cc1	10.1016/j.ejmech.2018.12.069
		118129974	163973	0	None	-	1	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4075819	163973	0	None	-	1	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		127036960	144167	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)ccc1C	10.1016/j.bmcl.2015.11.050
		CHEMBL3753188	144167	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albuminPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)ccc1C	10.1016/j.bmcl.2015.11.050
		CHEMBL5274923	200609	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR1 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	460	6	2	8	3.3	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCS4(=O)=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		156009978	183877	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	410	7	1	4	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		CHEMBL4633252	183877	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at GPR40 (unknown origin)Agonist activity at GPR40 (unknown origin)	ChEMBL	410	7	1	4	5.2	CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccccc4)cn3c2)cc1	10.1016/j.bmc.2020.115574
		58379717	97083	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	546	7	1	3	8.2	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3F)[C@]3(CCC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml300427u
		CHEMBL2385463	97083	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayAgonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay	ChEMBL	546	7	1	3	8.2	COc1ccc(F)c(-c2ccc(COc3ccc4c(c3F)[C@]3(CCC4)C[C@H]3C(=O)O)cc2[C@@H]2CCCC2(C)C)c1	10.1021/ml300427u
		118151370	165882	0	None	-	1	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4097527	165882	0	None	-	1	Rat	7.0	pEC50	=	7.0	Binding	Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assayAgonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL5274742	200605	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisPositive allosteric modulation of human GPR40 by calcium based FLIPR analysis	ChEMBL	524	7	1	5	5.6	COc1ccc(F)c(N2C[C@@H](C)[C@H](Oc3ccc(N4C[C@H](C(F)(F)F)C[C@@H]4CC(=O)O)cc3)[C@@H](C)C2)c1	10.1016/j.bmc.2023.117273
		127036960	144167	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)ccc1C	10.1016/j.bmcl.2015.11.050
		CHEMBL3753188	144167	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serumPartial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum	ChEMBL	474	8	1	4	6.5	Cc1cc(Cl)ccc1-c1cc(COc2ccc([C@H](CC(=O)O)c3nccn3C)cc2)ccc1C	10.1016/j.bmcl.2015.11.050
		54580627	68941	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
		CHEMBL1777875	68941	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
		53248846	68927	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777861	68927	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	414	7	1	3	5.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1	10.1016/j.bmcl.2011.03.114
		54582629	68930	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777864	68930	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	355	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
		54584572	68944	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	455	6	1	5	4.8	CC#C[C@@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		CHEMBL1777878	68944	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	455	6	1	5	4.8	CC#C[C@@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		53248848	68942	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		CHEMBL1777876	68942	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	455	6	1	5	4.8	CC#CC(c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		127040096	143390	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Antagonist activity against rat GPR40Antagonist activity against rat GPR40	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2ccc(F)c(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
		CHEMBL3739712	143390	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Antagonist activity against rat GPR40Antagonist activity against rat GPR40	ChEMBL	331	4	0	4	3.8	Cc1cc(COc2ccc(F)c(F)c2F)nc(-c2ccccn2)n1	10.1039/C5MD00037H
		54586485	68931	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	398	5	1	2	6.2	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777865	68931	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	398	5	1	2	6.2	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)c3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
		54586484	68928	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777862	68928	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	339	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
		54583582	68938	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	431	6	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OC2CCCc3nc(-c4ccc(C)cc4)sc32)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777872	68938	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	431	6	1	4	6.2	CC#CC(CC(=O)O)c1ccc(OC2CCCc3nc(-c4ccc(C)cc4)sc32)cc1	10.1016/j.bmcl.2011.03.114
		54584571	68943	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	455	6	1	5	4.8	CC#C[C@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		CHEMBL1777877	68943	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	455	6	1	5	4.8	CC#C[C@H](c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1)[C@H]1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		54583581	68934	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	307	5	1	5	2.7	CC#CC(CC(=O)O)c1ccc(Oc2nccnc2C#N)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777868	68934	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	307	5	1	5	2.7	CC#CC(CC(=O)O)c1ccc(Oc2nccnc2C#N)cc1	10.1016/j.bmcl.2011.03.114
		54582630	68932	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777866	68932	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	383	5	1	3	5.1	CC#CC(CC(=O)O)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1	10.1016/j.bmcl.2011.03.114
		127041988	143612	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity against rat GPR40Antagonist activity against rat GPR40	ChEMBL	421	7	0	6	3.7	Fc1ccc(OCc2cc(OCC3(F)COC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
		CHEMBL3741735	143612	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity against rat GPR40Antagonist activity against rat GPR40	ChEMBL	421	7	0	6	3.7	Fc1ccc(OCc2cc(OCC3(F)COC3)nc(-c3ccccn3)n2)c(F)c1F	10.1039/C5MD00037H
		54580625	68939	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	272	5	1	2	3.6	CC#CC(CC(=O)O)c1ccc(OC2CCCC2)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777873	68939	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	272	5	1	2	3.6	CC#CC(CC(=O)O)c1ccc(OC2CCCC2)cc1	10.1016/j.bmcl.2011.03.114
		54581633	68935	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	331	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2nccc3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777869	68935	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	331	5	1	3	4.6	CC#CC(CC(=O)O)c1ccc(Oc2nccc3ccccc23)cc1	10.1016/j.bmcl.2011.03.114
		54580626	68940	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
		CHEMBL1777874	68940	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	394	4	1	2	5.5	CC#C[C@]1(c2ccc(Oc3ccc(C(F)(F)F)cc3Cl)cc2)C[C@@H]1C(=O)O	10.1016/j.bmcl.2011.03.114
		54582628	68929	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	383	5	1	3	4.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Br)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777863	68929	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	383	5	1	3	4.7	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C#N)cc2Br)cc1	10.1016/j.bmcl.2011.03.114
		54580624	68926	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	362	5	1	2	5.4	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2C)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777860	68926	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	362	5	1	2	5.4	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2C)cc1	10.1016/j.bmcl.2011.03.114
		54586486	68936	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	320	5	1	2	4.3	CC#CC(CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777870	68936	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	320	5	1	2	4.3	CC#CC(CC(=O)O)c1ccc(O[C@@H]2CCc3ccccc32)cc1	10.1016/j.bmcl.2011.03.114
		54582631	68933	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	360	5	1	4	3.6	CC#CC(CC(=O)O)c1ccc(Oc2ncc(Br)cn2)cc1	10.1016/j.bmcl.2011.03.114
		CHEMBL1777867	68933	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	360	5	1	4	3.6	CC#CC(CC(=O)O)c1ccc(Oc2ncc(Br)cn2)cc1	10.1016/j.bmcl.2011.03.114
		54585512	68937	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	335	5	1	4	3.0	CC#CC(c1ccc(OCc2ccccc2)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		CHEMBL1777871	68937	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	335	5	1	4	3.0	CC#CC(c1ccc(OCc2ccccc2)cc1)C1OC(=O)NC1=O	10.1016/j.bmcl.2011.03.114
		53248847	68921	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
		CHEMBL1777855	68921	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayInhibition of human GPR40 expressed in CHO cells by SPA based binding assay	ChEMBL	432	7	1	3	5.8	CC#CC(CC(=O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2OC(F)F)cc1F	10.1016/j.bmcl.2011.03.114
		126961699	143458	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Antagonist activity against rat GPR40Antagonist activity against rat GPR40	ChEMBL	411	5	0	6	3.9	CC1(C#N)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
		CHEMBL3740291	143458	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Antagonist activity against rat GPR40Antagonist activity against rat GPR40	ChEMBL	411	5	0	6	3.9	CC1(C#N)CN(c2cc(COc3ccc(F)c(F)c3F)nc(-c3ccccn3)n2)C1	10.1039/C5MD00037H
		16661950	144444	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Modulation of FFAR1 (unknown origin)Modulation of FFAR1 (unknown origin)	ChEMBL	415	10	1	6	4.2	CCOC(=O)CCCCCOc1ccc2cc(CC3SC(=O)NC3=O)ccc2c1	10.1016/j.ejmech.2015.12.049
		CHEMBL3758511	144444	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Modulation of FFAR1 (unknown origin)Modulation of FFAR1 (unknown origin)	ChEMBL	415	10	1	6	4.2	CCOC(=O)CCCCCOc1ccc2cc(CC3SC(=O)NC3=O)ccc2c1	10.1016/j.ejmech.2015.12.049
		16058685	179338	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Modulation of FFAR1 (unknown origin)Modulation of FFAR1 (unknown origin)	ChEMBL	229	7	1	3	3.1	CCCCCCCCC1SC(=O)NC1=O	10.1016/j.ejmech.2015.12.049
		CHEMBL448569	179338	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Modulation of FFAR1 (unknown origin)Modulation of FFAR1 (unknown origin)	ChEMBL	229	7	1	3	3.1	CCCCCCCCC1SC(=O)NC1=O	10.1016/j.ejmech.2015.12.049
		46854655	7183	47	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		6485	7183	47	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		CHEMBL1829173	7183	47	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		24857286	8405	72	None	10	2	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisBinding affinity to human GPR40 expressed in CHO cells by LC-MS analysis	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.0c00843
		6484	8405	72	None	10	2	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisBinding affinity to human GPR40 expressed in CHO cells by LC-MS analysis	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.0c00843
		CHEMBL1829174	8405	72	None	10	2	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisBinding affinity to human GPR40 expressed in CHO cells by LC-MS analysis	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.0c00843
		DB12491	8405	72	None	10	2	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisBinding affinity to human GPR40 expressed in CHO cells by LC-MS analysis	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.0c00843
		52936292	188889	27	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4782004	188889	27	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		67087246	189656	5	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4791842	189656	5	None	-	1	Human	8.7	pKd	=	8.7	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		51049992	152397	5	None	-	1	Human	8.6	pKd	=	8.6	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3915620	152397	5	None	-	1	Human	8.6	pKd	=	8.6	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		68194743	189327	12	None	-	1	Human	8.5	pKd	=	8.5	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787498	189327	12	None	-	1	Human	8.5	pKd	=	8.5	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		162644059	188603	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		CHEMBL4778264	188603	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		127051856	147505	0	None	-	1	Human	8.4	pKd	=	8.4	Binding	Binding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 preincubated for 5 mins followed by TUG-905 addition measured after 15 mins by kinetic BRET assayBinding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 preincubated for 5 mins followed by TUG-905 addition measured after 15 mins by kinetic BRET assay	ChEMBL	630	16	2	10	6.3	Cc1cc(OCCOCCNc2ccc([N+](=O)[O-])c3nonc23)ccc1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/acs.jmedchem.6b00202
		CHEMBL3817889	147505	0	None	-	1	Human	8.4	pKd	=	8.4	Binding	Binding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 preincubated for 5 mins followed by TUG-905 addition measured after 15 mins by kinetic BRET assayBinding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 preincubated for 5 mins followed by TUG-905 addition measured after 15 mins by kinetic BRET assay	ChEMBL	630	16	2	10	6.3	Cc1cc(OCCOCCNc2ccc([N+](=O)[O-])c3nonc23)ccc1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/acs.jmedchem.6b00202
		24857286	8405	72	None	10	2	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		6484	8405	72	None	10	2	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		CHEMBL1829174	8405	72	None	10	2	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		DB12491	8405	72	None	10	2	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		57706778	87572	29	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisBinding affinity to human GPR40 expressed in CHO cells by LC-MS analysis	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acs.jmedchem.0c00843
		CHEMBL2152070	87572	29	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisBinding affinity to human GPR40 expressed in CHO cells by LC-MS analysis	ChEMBL	514	10	1	3	8.3	COc1ccc(F)c(-c2ccc(COc3cccc([C@@H](CC(=O)O)C4CC4)c3)cc2C2=CCCC2(C)C)c1	10.1021/acs.jmedchem.0c00843
		58230552	188998	0	None	-	1	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4783190	188998	0	None	-	1	Human	7.2	pKd	=	7.2	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		127051856	147505	0	None	-	1	Human	8.1	pKd	=	8.1	Binding	Binding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayBinding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	630	16	2	10	6.3	Cc1cc(OCCOCCNc2ccc([N+](=O)[O-])c3nonc23)ccc1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/acs.jmedchem.6b00202
		CHEMBL3817889	147505	0	None	-	1	Human	8.1	pKd	=	8.1	Binding	Binding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayBinding affinity to N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	630	16	2	10	6.3	Cc1cc(OCCOCCNc2ccc([N+](=O)[O-])c3nonc23)ccc1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/acs.jmedchem.6b00202
		51357276	188786	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4780641	188786	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assayDisplacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162668378	189286	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787010	189286	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	559	8	1	3	7.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.6b00892
		162673875	189765	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4793371	189765	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	505	8	1	3	6.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(C)c2)cc1	10.1021/acs.jmedchem.6b00892
		67087095	190154	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797858	190154	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	570	9	1	4	7.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(c3ccccc3)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		162674654	190234	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798993	190234	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	525	8	1	3	7.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(Cl)c2)cc1	10.1021/acs.jmedchem.6b00892
		67085761	163804	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	485	8	1	4	6.6	Cc1cc(OCc2ccccc2)ccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4073525	163804	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	485	8	1	4	6.6	Cc1cc(OCc2ccccc2)ccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		57413290	82601	0	None	2	2	Rat	8.0	pKi	=	8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	448	12	1	4	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048617	82601	0	None	2	2	Rat	8.0	pKi	=	8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	448	12	1	4	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		23111682	80877	0	None	-5	2	Rat	7.0	pKi	=	7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022576	80877	0	None	-5	2	Rat	7.0	pKi	=	7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		68194159	189840	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4794233	189840	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2sc(CN3CCC4(C=Cc5ccccc54)CC3)nc2C)cc1	10.1021/acs.jmedchem.6b00892
		23083015	82595	0	None	-19	2	Rat	5.0	pKi	=	5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(-c2c(C)cccc2C)cc1COc1ccc(CCC(=O)O)cc1	10.1021/jm2016123
		CHEMBL2048611	82595	0	None	-19	2	Rat	5.0	pKi	=	5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(-c2c(C)cccc2C)cc1COc1ccc(CCC(=O)O)cc1	10.1021/jm2016123
		118129998	164102	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4077366	164102	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	485	11	1	7	4.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCOC)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		57414677	82400	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	552	13	1	6	5.8	CCc1cc(OCCCS(C)(=O)=O)cc(CC)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047164	82400	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	552	13	1	6	5.8	CCc1cc(OCCCS(C)(=O)=O)cc(CC)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		51357276	188786	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4780641	188786	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	508	8	1	4	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		11271473	81247	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022584	81247	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2027975	81247	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		57414402	82389	0	None	-4	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047152	82389	0	None	-4	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		24857375	82405	0	None	-5	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	558	11	1	6	6.0	Cc1cc(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047169	82405	0	None	-5	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	558	11	1	6	6.0	Cc1cc(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		23111781	80825	0	None	-6	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022247	80825	0	None	-6	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		23111781	80825	0	None	-6	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022247	80825	0	None	-6	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/ml1000855
		57414543	82398	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	529	9	1	6	7.2	Cc1nc(C)c(COc2cc(C)c(-c3cccc(COc4ccc5c(c4)OC[C@H]5CC(=O)O)c3)c(C)c2)s1	10.1021/jm300170m
		CHEMBL2047162	82398	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	529	9	1	6	7.2	Cc1nc(C)c(COc2cc(C)c(-c3cccc(COc4ccc5c(c4)OC[C@H]5CC(=O)O)c3)c(C)c2)s1	10.1021/jm300170m
		24857376	82406	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	592	11	1	6	6.6	Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047170	82406	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	592	11	1	6	6.6	Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57413373	82602	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	12	1	4	6.1	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048618	82602	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	12	1	4	6.1	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		57413375	83994	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
		CHEMBL2048620	83994	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
		CHEMBL2079468	83994	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
		57414679	82402	0	None	-3	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	552	11	1	6	5.9	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OCCCS(C)(=O)=O	10.1021/jm300170m
		CHEMBL2047166	82402	0	None	-3	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	552	11	1	6	5.9	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OCCCS(C)(=O)=O	10.1021/jm300170m
		57413287	82596	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	408	8	1	3	5.7	COc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)cccc2C)c1	10.1021/jm2016123
		CHEMBL2048612	82596	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	408	8	1	3	5.7	COc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)cccc2C)c1	10.1021/jm2016123
		68194449	189593	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4790921	189593	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cnc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		57325674	80827	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	372	6	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022249	80827	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	372	6	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CC3CC(=O)O)c1	10.1021/jm2012968
		58218673	164304	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	413	5	1	3	5.7	Cc1c(Cl)cccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4079930	164304	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	413	5	1	3	5.7	Cc1c(Cl)cccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		162667620	189336	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4787628	189336	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		23111693	80833	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	418	7	1	4	5.5	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-c1c(C)cccc1C	10.1021/jm2012968
		CHEMBL2022255	80833	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	418	7	1	4	5.5	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-c1c(C)cccc1C	10.1021/jm2012968
		23111766	80836	0	None	-3	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	402	6	1	3	5.8	Cc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022258	80836	0	None	-3	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	402	6	1	3	5.8	Cc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		68194127	189974	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4795763	189974	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	498	8	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ncc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		58218740	163224	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	315	5	1	3	4.1	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2F)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4067052	163224	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	315	5	1	3	4.1	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2F)cc1	10.1021/acs.jmedchem.6b01559
		58218551	165826	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	309	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4096887	165826	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	309	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		561372	65601	65	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/acs.jmedchem.6b00202
		CHEMBL1688452	65601	65	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/acs.jmedchem.6b00202
		67087173	189239	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4786335	189239	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	522	8	1	4	6.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		24857286	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		6484	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		CHEMBL1829174	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		DB12491	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		24857286	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		6484	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		CHEMBL1829174	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		DB12491	8405	72	None	-10	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		91809187	153902	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL3927519	153902	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	439	7	1	5	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		57414676	82399	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	534	9	1	6	6.7	Cc1cc(OCc2cccc3nccn23)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047163	82399	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	534	9	1	6	6.7	Cc1cc(OCc2cccc3nccn23)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		11190525	82600	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	10	1	3	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		CHEMBL2048616	82600	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	10	1	3	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		11226058	82605	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	514	12	1	5	5.5	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048622	82605	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	514	12	1	5	5.5	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		57413289	82599	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	430	10	1	3	6.4	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		CHEMBL2048615	82599	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	430	10	1	3	6.4	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		11203294	82606	3	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048623	82606	3	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		162676686	190265	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4799453	190265	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	523	8	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1	10.1021/acs.jmedchem.6b00892
		11203294	82606	3	None	-2	5	Human	7.8	pKi	=	7.8	Binding	FFAR1 binding assayFFAR1 binding assay	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.6019/CHEMBL5058642
		CHEMBL2048623	82606	3	None	-2	5	Human	7.8	pKi	=	7.8	Binding	FFAR1 binding assayFFAR1 binding assay	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.6019/CHEMBL5058642
		23111693	80833	0	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	418	7	1	4	5.5	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-c1c(C)cccc1C	10.1021/jm2012968
		CHEMBL2022255	80833	0	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	418	7	1	4	5.5	COc1ccc(COc2ccc3c(c2)OCC3CC(=O)O)cc1-c1c(C)cccc1C	10.1021/jm2012968
		23111689	80835	0	None	-27	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1ccc(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022257	80835	0	None	-27	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1ccc(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		71457285	89432	27	None	-4	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2179472	89432	27	None	-4	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/ml1000855
		23111781	80825	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022247	80825	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		23111694	80834	0	None	-24	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cccc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1OCc1ccccc1	10.1021/jm2012968
		CHEMBL2022256	80834	0	None	-24	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cccc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1OCc1ccccc1	10.1021/jm2012968
		57414405	82392	0	None	-4	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047155	82392	0	None	-4	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		24857285	82394	0	None	-7	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	566	9	2	7	4.8	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047157	82394	0	None	-7	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	566	9	2	7	4.8	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57414539	82395	0	None	-4	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	524	11	1	6	5.3	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2047158	82395	0	None	-4	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	524	11	1	6	5.3	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		57414540	82397	0	None	-5	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	529	11	1	5	5.9	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047160	82397	0	None	-5	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	529	11	1	5	5.9	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		23111781	80825	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022247	80825	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	388	6	1	3	5.5	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/ml1000855
		23111682	80877	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022576	80877	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		23642299	82404	1	None	11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	542	11	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047168	82404	1	None	11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	542	11	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		12002202	82609	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	525	9	2	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048626	82609	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	525	9	2	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		23157282	83995	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048628	83995	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2079469	83995	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		58218694	165250	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	327	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2C[C@@H](F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4090766	165250	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	327	5	1	2	4.0	Cc1ccccc1Cc1ccc(N2C[C@@H](F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		137653896	165324	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	326	6	1	4	3.4	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cn1	10.1021/acs.jmedchem.6b01559
		CHEMBL4091552	165324	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	326	6	1	4	3.4	Cc1ccccc1COc1ccc(N2CCC[C@H]2CC(=O)O)cn1	10.1021/acs.jmedchem.6b01559
		24857375	82405	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	558	11	1	6	6.0	Cc1cc(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047169	82405	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	558	11	1	6	6.0	Cc1cc(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		11398822	82607	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	556	10	2	6	5.0	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048624	82607	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	556	10	2	6	5.0	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		12002201	82610	1	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	555	10	3	6	5.1	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048627	82610	1	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	555	10	3	6	5.1	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		57414676	82399	0	None	-12	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	534	9	1	6	6.7	Cc1cc(OCc2cccc3nccn23)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047163	82399	0	None	-12	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	534	9	1	6	6.7	Cc1cc(OCc2cccc3nccn23)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		46854655	7183	47	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		6485	7183	47	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		CHEMBL1829173	7183	47	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00892
		162664735	188865	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4781604	188865	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	521	9	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(OC)c2)cc1	10.1021/acs.jmedchem.6b00892
		67087100	189377	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4788206	189377	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	576	8	1	4	6.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(C(F)(F)F)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		11236925	82603	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	478	9	1	4	6.3	Cc1cc(OC2CCOCC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048619	82603	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	478	9	1	4	6.3	Cc1cc(OC2CCOCC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		12002185	82608	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	513	12	2	5	5.6	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048625	82608	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	513	12	2	5	5.6	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		68194476	189666	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792075	189666	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	481	8	1	4	6.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)o2)cc1	10.1021/acs.jmedchem.6b00892
		23111734	80878	0	None	-7	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022577	80878	0	None	-7	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		23642299	82404	1	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	542	11	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047168	82404	1	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	542	11	1	6	5.5	Cc1cc(OCCCS(C)(=O)=O)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		58230598	189898	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		CHEMBL4794904	189898	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	487	8	1	3	6.5	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1Cl	10.1021/acs.jmedchem.6b00892
		67072752	93304	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.6b00202
		CHEMBL2315528	93304	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.6b00202
		57414401	82388	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047151	82388	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		11489259	82604	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	519	12	1	4	6.1	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048621	82604	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	519	12	1	4	6.1	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		23111668	80821	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022243	80821	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/jm2012968
		57414404	82391	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047154	82391	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		23111668	80821	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022243	80821	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/ml1000855
		57325916	80882	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	488	11	1	4	6.5	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022581	80882	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	488	11	1	4	6.5	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
		1050	8683	94	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.6b00202
		11595431	8683	94	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.6b00202
		CHEMBL207881	8683	94	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.6b00202
		57414403	82390	0	None	-8	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047153	82390	0	None	-8	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		57414267	82386	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2047149	82386	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		57413290	82601	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	448	12	1	4	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048617	82601	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	448	12	1	4	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL5075693	221169	3	None	-	1	Human	7.6	pKi	=	7.6	Binding	FFAR1 biochemical assayFFAR1 biochemical assay	ChEMBL		None	None	None		Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O	10.6019/CHEMBL5058643
		137649008	163925	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	323	5	1	2	4.4	Cc1ccccc1Cc1ccc(N2CCC[C@@]2(C)CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4075190	163925	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	323	5	1	2	4.4	Cc1ccccc1Cc1ccc(N2CCC[C@@]2(C)CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		24857285	82394	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	566	9	2	7	4.8	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047157	82394	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	566	9	2	7	4.8	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57414267	82386	0	None	-10	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2047149	82386	0	None	-10	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		23111754	80823	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022245	80823	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/jm2012968
		23111754	80823	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022245	80823	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	414	6	1	2	6.8	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCCC3CC(=O)O)c1	10.1021/ml1000855
		57414402	82389	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047152	82389	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57413288	82598	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048614	82598	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		71257551	157372	24	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL3955132	157372	24	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	475	9	1	5	5.9	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCCc4cccc(OC)c43)s2)cc1	10.1021/acs.jmedchem.7b01411
		11674915	65636	1	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		CHEMBL1688486	65636	1	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		11327107	80826	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/jm2012968
		CHEMBL2022248	80826	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/jm2012968
		57325841	80880	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	474	11	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022579	80880	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	474	11	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CC(CC(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
		57414403	82390	0	None	8	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047153	82390	0	None	8	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		57414680	82403	0	None	-8	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	554	8	1	6	5.6	Cc1cc(OC2CCS(=O)(=O)CC2)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047167	82403	0	None	-8	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	554	8	1	6	5.6	Cc1cc(OC2CCS(=O)(=O)CC2)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		11327107	80826	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/ml1000855
		CHEMBL2022248	80826	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	402	5	1	3	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)OCCC(C(=O)O)C3)c1	10.1021/ml1000855
		24857286	8405	72	None	10	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		6484	8405	72	None	10	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		CHEMBL1829174	8405	72	None	10	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		DB12491	8405	72	None	10	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		57325842	80881	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	474	10	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(C(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022580	80881	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	474	10	1	4	6.2	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)CCC(C(=O)O)C4)c2)c(C)c1	10.1021/jm2012968
		57414268	82387	0	None	26	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2047150	82387	0	None	26	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		67087160	189123	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4784555	189123	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	538	9	1	5	5.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3ccc(OC)cc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		23111666	80831	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4csc5ccccc45)c3)ccc21	10.1021/jm2012968
		CHEMBL2022253	80831	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4csc5ccccc45)c3)ccc21	10.1021/jm2012968
		67087041	189150	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4785057	189150	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	542	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C)c3c(Cl)cccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		68194465	190085	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4797124	190085	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	511	8	1	4	6.8	CC#C[C@@H](CC(=O)O)c1ccc(OCc2cc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		23083189	82594	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	374	7	1	2	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm2016123
		CHEMBL2048610	82594	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	374	7	1	2	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm2016123
		57414538	82393	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047156	82393	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		23111734	80878	0	None	-7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2022577	80878	0	None	-7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		57414540	82397	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	529	11	1	5	5.9	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047160	82397	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	529	11	1	5	5.9	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57414680	82403	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	554	8	1	6	5.6	Cc1cc(OC2CCS(=O)(=O)CC2)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047167	82403	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	554	8	1	6	5.6	Cc1cc(OC2CCS(=O)(=O)CC2)c(F)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		137638269	163655	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	433	7	1	3	5.8	COc1ccc(F)c(-c2ccc(Cc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL4071899	163655	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	433	7	1	3	5.8	COc1ccc(F)c(-c2ccc(Cc3ccc(N4CCC[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		58218640	165701	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2CC[C@H](C)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4095599	165701	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2CC[C@H](C)[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		132578495	189665	2	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4792027	189665	2	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	491	8	1	3	6.4	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		118129999	164546	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4082711	164546	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	453	8	1	5	5.7	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C(C)C)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		51350138	65623	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2012968
		CHEMBL1688473	65623	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2012968
		23111734	80878	0	None	7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022577	80878	0	None	7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		23111734	80878	0	None	7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2022577	80878	0	None	7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		51350138	65623	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL1688473	65623	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		51350138	65623	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml1000855
		CHEMBL1688473	65623	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml1000855
		57414679	82402	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	552	11	1	6	5.9	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OCCCS(C)(=O)=O	10.1021/jm300170m
		CHEMBL2047166	82402	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	552	11	1	6	5.9	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OCCCS(C)(=O)=O	10.1021/jm300170m
		58218651	165098	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	379	5	1	3	5.0	Cc1ccccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4089171	165098	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	379	5	1	3	5.0	Cc1ccccc1Oc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		118129979	162573	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4059614	162573	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	436	7	1	6	4.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(C#N)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		23111766	80836	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	402	6	1	3	5.8	Cc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022258	80836	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	402	6	1	3	5.8	Cc1cc(C)c(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		57414405	82392	0	None	4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047155	82392	0	None	4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		51350138	65623	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL1688473	65623	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		58218607	162719	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2C[C@@H](C)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4061093	162719	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	323	5	1	2	4.3	Cc1ccccc1Cc1ccc(N2C[C@@H](C)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		57414543	82398	0	None	-30	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	529	9	1	6	7.2	Cc1nc(C)c(COc2cc(C)c(-c3cccc(COc4ccc5c(c4)OC[C@H]5CC(=O)O)c3)c(C)c2)s1	10.1021/jm300170m
		CHEMBL2047162	82398	0	None	-30	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	529	9	1	6	7.2	Cc1nc(C)c(COc2cc(C)c(-c3cccc(COc4ccc5c(c4)OC[C@H]5CC(=O)O)c3)c(C)c2)s1	10.1021/jm300170m
		118129981	166246	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4101472	166246	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	513	11	2	7	5.1	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OCCC(C)(C)O)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		57414539	82395	0	None	4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	524	11	1	6	5.3	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2047158	82395	0	None	4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	524	11	1	6	5.3	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		71457285	89432	27	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2179472	89432	27	None	4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/ml1000855
		23111704	80822	0	None	-63	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022244	80822	0	None	-63	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/jm2012968
		23111704	80822	0	None	-63	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022244	80822	0	None	-63	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/ml1000855
		24857286	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		6484	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		CHEMBL1829174	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		DB12491	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/jm300170m
		24857286	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		6484	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		CHEMBL1829174	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		DB12491	8405	72	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/ml1000855
		51031010	163410	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	409	6	1	4	5.0	COc1ccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c(C)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL4069191	163410	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	409	6	1	4	5.0	COc1ccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c(C)c1	10.1021/acs.jmedchem.6b01559
		57325917	80883	0	None	-5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)COC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022582	80883	0	None	-5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)COC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		162674998	190170	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4798023	190170	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	509	8	1	3	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)c(F)c2)cc1	10.1021/acs.jmedchem.6b00892
		162676881	190364	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4800563	190364	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	536	9	1	4	6.6	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CC3)CN(C(C)C)c3ccccc34)cc2)cc1	10.1021/acs.jmedchem.6b00892
		11226058	82605	0	None	3	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	514	12	1	5	5.5	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048622	82605	0	None	3	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	514	12	1	5	5.5	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		60195125	10660	8	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		9149	10660	8	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		CHEMBL2164242	10660	8	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00202
		57413373	82602	0	None	2	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	12	1	4	6.1	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048618	82602	0	None	2	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	12	1	4	6.1	CCOCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		12002185	82608	0	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	513	12	2	5	5.6	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048625	82608	0	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	513	12	2	5	5.6	CCS(=O)(=O)CCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		12002201	82610	1	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	555	10	3	6	5.1	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048627	82610	1	None	4	2	Rat	8.4	pKi	=	8.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	555	10	3	6	5.1	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		67087246	189656	5	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4791842	189656	5	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	493	8	1	3	6.3	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		51049992	152397	5	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL3915620	152397	5	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.7b01411
		51049992	152397	5	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL3915620	152397	5	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	491	8	1	3	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1	10.1021/acs.jmedchem.6b00892
		52936292	188889	27	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4782004	188889	27	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	497	8	1	4	6.5	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		57414678	82401	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	564	8	1	6	6.1	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OC1CCS(=O)(=O)CC1	10.1021/jm300170m
		CHEMBL2047165	82401	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	564	8	1	6	6.1	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OC1CCS(=O)(=O)CC1	10.1021/jm300170m
		57414678	82401	0	None	-10	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	564	8	1	6	6.1	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OC1CCS(=O)(=O)CC1	10.1021/jm300170m
		CHEMBL2047165	82401	0	None	-10	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	564	8	1	6	6.1	Cc1c(C)c(-c2cccc(COc3ccc4c(c3)OC[C@H]4CC(=O)O)c2)c(C)c(C)c1OC1CCS(=O)(=O)CC1	10.1021/jm300170m
		23111791	80830	0	None	11	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	424	6	1	3	6.3	Cc1ccc2ccccc2c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022252	80830	0	None	11	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	424	6	1	3	6.3	Cc1ccc2ccccc2c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		46854655	7183	47	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
		6485	7183	47	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
		CHEMBL1829173	7183	47	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	438	7	1	2	6.5	CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O	10.1021/acs.jmedchem.6b00202
		162666840	189233	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4786299	189233	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	509	8	1	3	6.5	CC#C[C@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		11271473	81247	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022584	81247	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2027975	81247	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	475	11	2	5	5.9	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		58218638	164215	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	311	5	1	3	4.2	Cc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4078852	164215	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	311	5	1	3	4.2	Cc1ccccc1Oc1ccc(N2CCC[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		132606864	164525	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL4082395	164525	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	501	7	1	3	6.6	COc1ccc(F)c(-c2ccc(Cc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c(C)c2)c1	10.1021/acs.jmedchem.6b01559
		11674915	65636	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		CHEMBL1688486	65636	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	360	7	1	2	5.6	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		23082877	82597	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1-c1c(C)cccc1C	10.1021/jm2016123
		CHEMBL2048613	82597	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1-c1c(C)cccc1C	10.1021/jm2016123
		23111791	80830	0	None	-11	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	424	6	1	3	6.3	Cc1ccc2ccccc2c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022252	80830	0	None	-11	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	424	6	1	3	6.3	Cc1ccc2ccccc2c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm2012968
		137636358	162665	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	517	8	1	4	6.8	COc1ccc(F)c(Cc2cccc(Oc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
		CHEMBL4060499	162665	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	517	8	1	4	6.8	COc1ccc(F)c(Cc2cccc(Oc3ccc(N4C[C@@H](C(F)(F)F)C[C@H]4CC(=O)O)cc3)c2C)c1	10.1021/acs.jmedchem.6b01559
		12002202	82609	0	None	3	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	525	9	2	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048626	82609	0	None	3	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	525	9	2	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		57413289	82599	0	None	2	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	430	10	1	3	6.4	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		CHEMBL2048615	82599	0	None	2	2	Rat	8.3	pKi	=	8.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	430	10	1	3	6.4	Cc1cc(OCC2CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		46941175	68586	26	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b00202
		CHEMBL1773261	68586	26	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/acs.jmedchem.6b00202
		57414538	82393	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047156	82393	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@@H]3CC(=O)O)c1	10.1021/jm300170m
		23111668	80821	0	None	-2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022243	80821	0	None	-2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/jm2012968
		23083015	82595	0	None	19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(-c2c(C)cccc2C)cc1COc1ccc(CCC(=O)O)cc1	10.1021/jm2016123
		CHEMBL2048611	82595	0	None	19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(-c2c(C)cccc2C)cc1COc1ccc(CCC(=O)O)cc1	10.1021/jm2016123
		23111668	80821	0	None	-2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022243	80821	0	None	-2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	386	6	1	2	6.1	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCC3CC(=O)O)c1	10.1021/ml1000855
		51350138	65623	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2012968
		CHEMBL1688473	65623	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2012968
		51350138	65623	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml1000855
		CHEMBL1688473	65623	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml1000855
		57414677	82400	0	None	-5	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	552	13	1	6	5.8	CCc1cc(OCCCS(C)(=O)=O)cc(CC)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047164	82400	0	None	-5	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	552	13	1	6	5.8	CCc1cc(OCCCS(C)(=O)=O)cc(CC)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		23111689	80835	0	None	27	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1ccc(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022257	80835	0	None	27	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	388	6	1	3	5.5	Cc1ccc(-c2cccc(COc3ccc4c(c3)OCC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		23111671	80832	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4ccc5sccc5c4)c3)ccc21	10.1021/jm2012968
		CHEMBL2022254	80832	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	416	6	1	4	6.1	O=C(O)CC1COc2cc(OCc3cccc(-c4ccc5sccc5c4)c3)ccc21	10.1021/jm2012968
		23083189	82594	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	374	7	1	2	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm2016123
		CHEMBL2048610	82594	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	374	7	1	2	5.9	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1C	10.1021/jm2016123
		23111704	80822	0	None	63	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/jm2012968
		CHEMBL2022244	80822	0	None	63	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/jm2012968
		24857376	82406	0	None	-4	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	592	11	1	6	6.6	Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047170	82406	0	None	-4	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	592	11	1	6	6.6	Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		23111704	80822	0	None	63	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/ml1000855
		CHEMBL2022244	80822	0	None	63	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membranes after 90 mins by liquid scintillation counting in presence of 0.2 % BSA	ChEMBL	400	6	1	2	6.4	Cc1cccc(C)c1-c1cccc(COc2ccc3c(c2)CCCC3CC(=O)O)c1	10.1021/ml1000855
		68194237	188985	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4783033	188985	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	512	8	1	5	6.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2nc(C)c(CN3CCC4(C=Cc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		57413288	82598	0	None	4	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048614	82598	0	None	4	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)O)cc3)c2)c(C)c1	10.1021/jm2016123
		23157282	83995	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2048628	83995	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		CHEMBL2079469	83995	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	465	12	2	4	6.2	CCOCCOc1cc(C)c(-c2cccc(CNc3ccc(CCC(=O)O)c(F)c3)c2)c(C)c1	10.1021/jm2016123
		11203294	82606	3	None	2	5	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048623	82606	3	None	2	5	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	526	9	1	5	5.7	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		11190525	82600	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	10	1	3	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		CHEMBL2048616	82600	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	466	10	1	3	7.1	Cc1cc(OCc2ccccc2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm2016123
		11236925	82603	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	478	9	1	4	6.3	Cc1cc(OC2CCOCC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048619	82603	0	None	2	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	478	9	1	4	6.3	Cc1cc(OC2CCOCC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		57413375	83994	0	None	1	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
		CHEMBL2048620	83994	0	None	1	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
		CHEMBL2079468	83994	0	None	1	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	485	9	1	4	7.2	Cc1cccc(Oc2cc(C)c(-c3cccc(COc4ccc(CCC(=O)O)c(F)c4)c3)c(C)c2)n1	10.1021/jm2016123
		23111694	80834	0	None	24	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cccc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1OCc1ccccc1	10.1021/jm2012968
		CHEMBL2022256	80834	0	None	24	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	494	9	1	4	7.1	Cc1cccc(C)c1-c1cc(COc2ccc3c(c2)OCC3CC(=O)O)ccc1OCc1ccccc1	10.1021/jm2012968
		58218709	165197	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	393	5	1	3	5.3	Cc1cccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c1C	10.1021/acs.jmedchem.6b01559
		CHEMBL4090240	165197	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	393	5	1	3	5.3	Cc1cccc(Oc2ccc(N3C[C@@H](C(F)(F)F)C[C@H]3CC(=O)O)cc2)c1C	10.1021/acs.jmedchem.6b01559
		118151370	165882	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4097527	165882	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	477	9	1	6	5.2	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4ccc(OC(F)F)cc4)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		118129974	163973	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4075819	163973	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	575	12	1	8	5.0	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)nn3c2)cc1	10.1021/acs.jmedchem.7b01411
		25150014	10657	55	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/acs.jmedchem.6b00202
		3952	10657	55	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/acs.jmedchem.6b00202
		CHEMBL449588	10657	55	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/acs.jmedchem.6b00202
		58218542	163545	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	297	5	1	3	3.9	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4070703	163545	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	297	5	1	3	3.9	O=C(O)C[C@@H]1CCCN1c1ccc(Oc2ccccc2)cc1	10.1021/acs.jmedchem.6b01559
		57414542	83991	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047161	83991	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2079433	83991	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57325917	80883	0	None	5	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)COC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		CHEMBL2022582	80883	0	None	5	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA	ChEMBL	476	11	1	5	6.0	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)COC4CC(=O)O)c2)c(C)c1	10.1021/jm2012968
		58230552	188998	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		CHEMBL4783190	188998	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	471	8	1	3	6.0	O=C(O)CCc1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1F	10.1021/acs.jmedchem.6b00892
		3367	7939	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/acs.jmedchem.6b00202
		46216676	7939	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/acs.jmedchem.6b00202
		CHEMBL604126	7939	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	416	4	1	5	4.7	O=C1NC(=O)C(S1)Cc1ccc(cc1C)Oc1ncc(cc1Cl)C(F)(F)F	10.1021/acs.jmedchem.6b00202
		24857286	8405	72	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		6484	8405	72	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		CHEMBL1829174	8405	72	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		DB12491	8405	72	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	524	11	1	6	5.3	OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C	10.1021/acs.jmedchem.6b00892
		58218608	163463	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	377	5	1	2	4.8	Cc1ccccc1Cc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4069764	163463	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	377	5	1	2	4.8	Cc1ccccc1Cc1ccc(N2C[C@@H](C(F)(F)F)C[C@H]2CC(=O)O)cc1	10.1021/acs.jmedchem.6b01559
		57414268	82387	0	None	-26	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		CHEMBL2047150	82387	0	None	-26	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	476	11	1	5	5.9	CCOCCOc1cc(C)c(-c2cccc(COc3ccc4c(c3)OC[C@@H]4CC(=O)O)c2)c(C)c1	10.1021/jm300170m
		162644059	188603	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		CHEMBL4778264	188603	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	440	8	1	7	4.6	O=C(O)C[C@@H](c1ccc(OCc2ccc3nc(-c4ccccc4)nn3c2)cc1)c1ccon1	10.1021/acs.jmedchem.6b00892
		137661294	166279	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	485	7	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(N3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.7b01411
		CHEMBL4101901	166279	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation countingCompetitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation counting	ChEMBL	485	7	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(N3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.7b01411
		11398822	82607	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	556	10	2	6	5.0	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048624	82607	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	556	10	2	6	5.0	Cc1cc(OCC2(O)CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		68194743	189327	12	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		CHEMBL4787498	189327	12	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting methodDisplacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method	ChEMBL	499	8	1	4	6.4	CC#C[C@@H](CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc54)CC3)s2)cc1	10.1021/acs.jmedchem.6b00892
		57414542	83991	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047161	83991	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2079433	83991	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	501	8	1	5	6.0	Cc1cc(OC2CCN(C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1	10.1021/jm300170m
		57414404	82391	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047154	82391	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	536	8	1	6	5.5	Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		57414401	82388	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		CHEMBL2047151	82388	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA	ChEMBL	488	9	1	5	5.9	Cc1cc(OCC2(C)COC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1	10.1021/jm300170m
		6483	10658	54	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
		66553168	10658	54	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
		CHEMBL2386353	10658	54	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assayDisplacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/acs.jmedchem.6b00202
		23082877	82597	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1-c1c(C)cccc1C	10.1021/jm2016123
		CHEMBL2048613	82597	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	390	8	1	3	5.6	COc1ccc(COc2ccc(CCC(=O)O)cc2)cc1-c1c(C)cccc1C	10.1021/jm2016123
		58218630	166434	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
		CHEMBL4103729	166434	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	379	6	1	3	5.0	O=C(O)C[C@@H]1CCCN1c1ccc(OCc2ccc(Cl)cc2Cl)cc1	10.1021/acs.jmedchem.6b01559
		11489259	82604	0	None	2	2	Rat	8.0	pKi	=	8.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	519	12	1	4	6.1	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		CHEMBL2048621	82604	0	None	2	2	Rat	8.0	pKi	=	8.0	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	519	12	1	4	6.1	Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm2016123
		58218655	162944	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	341	6	1	4	3.9	CO[C@H]1C[C@@H](CC(=O)O)N(c2ccc(Oc3ccccc3C)cc2)C1	10.1021/acs.jmedchem.6b01559
		CHEMBL4063889	162944	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting methodBinding affinity to human GPR40 expressed in HEK293 cell membranes after 1 hr by radioligand displacement based scintillation counting method	ChEMBL	341	6	1	4	3.9	CO[C@H]1C[C@@H](CC(=O)O)N(c2ccc(Oc3ccccc3C)cc2)C1	10.1021/acs.jmedchem.6b01559
		57413287	82596	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	408	8	1	3	5.7	COc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)cccc2C)c1	10.1021/jm2016123
		CHEMBL2048612	82596	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSADisplacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA	ChEMBL	408	8	1	3	5.7	COc1cc(COc2ccc(CCC(=O)O)c(F)c2)cc(-c2c(C)cccc2C)c1	10.1021/jm2016123
		137076846	7898	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	629	16	3	9	4.7	OC(=O)CCc1ccc(cc1F)OCc1cccc(c1)c1ccc(cc1C)OCCOCCNc1ccc(c2=NCN=c12)N(O)[O]	27074625
		9148	7898	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	629	16	3	9	4.7	OC(=O)CCc1ccc(cc1F)OCc1cccc(c1)c1ccc(cc1C)OCCOCCNc1ccc(c2=NCN=c12)N(O)[O]	27074625

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Main reference

Ligand source activities (1 row/activity)