Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
71508233 93849 0 None 676 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 355 10 1 3 3.9 CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326201 93849 0 None 676 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 355 10 1 3 3.9 CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
139451781 191637 0 None 2 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 289 5 1 5 1.5 CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
CHEMBL4852440 191637 0 None 2 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 289 5 1 5 1.5 CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
46865422 93846 0 None 181 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326199 93846 0 None 181 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
139451764 193046 0 None 2 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 275 4 1 5 1.1 COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
CHEMBL4873903 193046 0 None 2 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 275 4 1 5 1.1 COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
1357 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
1672 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
224 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
896 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
CHEMBL45 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
DB01065 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
198 7101 126 None 3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
82148 7101 126 None 3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
99 7101 126 None 3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
CHEMBL10878 7101 126 None 3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
DB06594 7101 126 None 3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
1357 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
1672 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
224 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
896 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
CHEMBL45 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
DB01065 9263 139 None -1 5 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
139451763 193112 0 None 1 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 305 8 1 5 2.4 CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 10.1021/acs.jmedchem.0c00627
CHEMBL4874954 193112 0 None 1 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 305 8 1 5 2.4 CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 10.1021/acs.jmedchem.0c00627
137647756 164723 0 None 213 2 Human 10.1 pEC50 = 10.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 259 4 2 3 1.7 CNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4084612 164723 0 None 213 2 Human 10.1 pEC50 = 10.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 259 4 2 3 1.7 CNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
9839629 106892 0 None 1 2 Human 10.0 pEC50 = 10.0 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 309 5 1 3 3.8 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL287560 106892 0 None 1 2 Human 10.0 pEC50 = 10.0 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 309 5 1 3 3.8 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
198 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2010.04.008
82148 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2010.04.008
99 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2010.04.008
CHEMBL10878 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2010.04.008
DB06594 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2010.04.008
198 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
82148 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
99 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
CHEMBL10878 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
DB06594 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
198 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
82148 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
99 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
CHEMBL10878 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
DB06594 7101 126 None 3 4 Human 10.0 pEC50 = 10 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
137655238 165664 0 None 891 2 Human 10.0 pEC50 = 10 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 275 4 2 3 1.9 CNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4095210 165664 0 None 891 2 Human 10.0 pEC50 = 10 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 275 4 2 3 1.9 CNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
71508232 93848 0 None 75 2 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 351 7 1 3 3.6 CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326200 93848 0 None 75 2 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 351 7 1 3 3.6 CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
10926138 214756 0 None 147 2 Human 9.8 pEC50 = 9.8 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 349 8 1 3 4.3 C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL97186 214756 0 None 147 2 Human 9.8 pEC50 = 9.8 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 349 8 1 3 4.3 C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
1357 9263 139 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
1672 9263 139 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
224 9263 139 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
896 9263 139 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
CHEMBL45 9263 139 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
DB01065 9263 139 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
198 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
82148 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
99 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
CHEMBL10878 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
DB06594 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
198 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
198 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
82148 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
82148 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
99 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
99 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
CHEMBL10878 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
CHEMBL10878 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
DB06594 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
DB06594 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
139451769 192921 0 None 5 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC 10.1021/acs.jmedchem.0c00627
CHEMBL4872217 192921 0 None 5 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC 10.1021/acs.jmedchem.0c00627
145982070 173254 0 None -1 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 283 3 1 2 3.2 COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4278248 173254 0 None -1 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 283 3 1 2 3.2 COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
145986532 174060 0 None 4 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 269 3 1 2 3.0 COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4293386 174060 0 None 4 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 269 3 1 2 3.0 COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
71508235 93850 0 None 14 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 327 8 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326203 93850 0 None 14 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 327 8 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 10.1016/j.bmc.2012.10.060
137636213 162865 0 None 47 2 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 5 2 3 2.1 CCNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4062947 162865 0 None 47 2 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 5 2 3 2.1 CCNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
137639112 163631 0 None 8128 2 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 245 4 2 3 1.5 COc1ccc2cccc(CCNC(N)=O)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4071572 163631 0 None 8128 2 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 245 4 2 3 1.5 COc1ccc2cccc(CCNC(N)=O)c2n1 10.1016/j.ejmech.2016.12.013
137660333 166299 0 None 3 2 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 244 4 1 3 1.9 COc1ccc2cccc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4102177 166299 0 None 3 2 Human 9.7 pEC50 = 9.7 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 244 4 1 3 1.9 COc1ccc2cccc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.12.013
198 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
82148 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
99 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
CHEMBL10878 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
DB06594 7101 126 None 3 4 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
71508234 7492 0 None 173 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 10.1016/j.bmc.2012.10.060
7924 7492 0 None 173 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 10.1016/j.bmc.2012.10.060
CHEMBL2326202 7492 0 None 173 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay
ChEMBL 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 10.1016/j.bmc.2012.10.060
139451795 192108 0 None -2 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 277 6 1 5 1.6 CCOc1nc2ccc(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4859677 192108 0 None -2 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 277 6 1 5 1.6 CCOc1nc2ccc(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
139451757 191610 0 None -3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 311 6 1 5 2.2 CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4852096 191610 0 None -3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 311 6 1 5 2.2 CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
145990662 173708 0 None 16 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 312 4 2 2 3.4 CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4286896 173708 0 None 16 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 312 4 2 2 3.4 CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
139451766 191226 0 None 4 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 325 7 1 5 2.6 CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4846505 191226 0 None 4 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 325 7 1 5 2.6 CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
139451761 191376 0 None -4 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4848885 191376 0 None -4 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
122220128 166454 0 None 27 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 309 6 2 3 2.3 COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 10.1039/C4MD00149D
CHEMBL4104020 166454 0 None 27 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 309 6 2 3 2.3 COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 10.1039/C4MD00149D
10385056 119013 0 None 354 2 Human 9.4 pEC50 = 9.4 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 379 9 1 4 4.3 C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL329086 119013 0 None 354 2 Human 9.4 pEC50 = 9.4 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 379 9 1 4 4.3 C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm0005252
145988741 174015 0 None 12 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 299 5 1 3 2.6 COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4292336 174015 0 None 12 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 299 5 1 3 2.6 COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
137645530 164502 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 260 4 1 4 2.1 COC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4082097 164502 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 260 4 1 4 2.1 COC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
11824364 119329 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 353 7 1 4 3.7 COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL329960 119329 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 353 7 1 4 3.7 COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 10.1021/jm0005252
164946945 197008 1 None 3 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5174929 197008 1 None 3 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
1357 9263 139 None -1 5 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
1672 9263 139 None -1 5 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
224 9263 139 None -1 5 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
896 9263 139 None -1 5 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
CHEMBL45 9263 139 None -1 5 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
DB01065 9263 139 None -1 5 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
1357 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
1672 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
224 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
896 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
CHEMBL45 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
DB01065 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
1357 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.04.008
1672 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.04.008
224 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.04.008
896 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.04.008
CHEMBL45 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.04.008
DB01065 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.04.008
1357 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
1672 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
224 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
896 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
CHEMBL45 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
DB01065 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
1357 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
1672 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
224 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
896 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
CHEMBL45 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
DB01065 9263 139 None -1 5 Human 9.3 pEC50 = 9.3 Functional
Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
44579115 188614 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 348 6 2 3 4.2 CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
CHEMBL477835 188614 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 348 6 2 3 4.2 CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
57781216 132625 0 None -8 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648356 132625 0 None -8 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
139451767 191783 0 None -5 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 263 5 1 5 1.2 COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
CHEMBL4854625 191783 0 None -5 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 263 5 1 5 1.2 COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
24954989 8314 1 None -25 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 10.1021/jm200385u
7774 8314 1 None -25 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 10.1021/jm200385u
CHEMBL1802025 8314 1 None -25 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 10.1021/jm200385u
139451780 192723 0 None 1 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 303 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 10.1021/acs.jmedchem.0c00627
CHEMBL4869463 192723 0 None 1 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 303 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 10.1021/acs.jmedchem.0c00627
145982333 173336 0 None 2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4279639 173336 0 None 2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
12985495 188165 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 377 8 2 3 4.5 CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
CHEMBL476341 188165 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 377 8 2 3 4.5 CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
23642307 165674 1 None 39 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
CHEMBL4095334 165674 1 None 39 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
53231366 69175 0 None 309 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 363 5 1 3 5.0 CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779804 69175 0 None 309 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 363 5 1 3 5.0 CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
168296374 199297 0 None -9 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
CHEMBL5209359 199297 0 None -9 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
53231465 69174 0 None 35 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 237 3 1 2 2.7 CC(=O)NCCc1csc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779803 69174 0 None 35 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 237 3 1 2 2.7 CC(=O)NCCc1csc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
145988269 173969 0 None 12 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 326 5 2 2 3.8 CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4291381 173969 0 None 12 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 326 5 2 2 3.8 CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
52918079 67529 0 None 2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 261 6 1 4 2.0 CCCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
CHEMBL1760947 67529 0 None 2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 261 6 1 4 2.0 CCCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
12985494 197408 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 363 7 2 3 4.1 CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
CHEMBL518113 197408 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 363 7 2 3 4.1 CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
127026423 144597 0 None 6 2 Human 9.2 pEC50 = 9.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 283 4 1 3 3.3 COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759802 144597 0 None 6 2 Human 9.2 pEC50 = 9.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 283 4 1 3 3.3 COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
137650611 164291 0 None 91 2 Human 9.2 pEC50 = 9.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 244 4 1 3 1.9 CNC(=O)CCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4079784 164291 0 None 91 2 Human 9.2 pEC50 = 9.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 244 4 1 3 1.9 CNC(=O)CCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
1353 10208 5 None 51 2 Human 9.1 pEC50 = 9.1 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm0005252
9998187 10208 5 None 51 2 Human 9.1 pEC50 = 9.1 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm0005252
CHEMBL33549 10208 5 None 51 2 Human 9.1 pEC50 = 9.1 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm0005252
10400294 25321 0 None - 1 Rat 9.1 pEC50 = 9.1 Functional
Agonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptorAgonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptor
ChEMBL 258 5 1 3 2.6 Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL127570 25321 0 None - 1 Rat 9.1 pEC50 = 9.1 Functional
Agonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptorAgonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptor
ChEMBL 258 5 1 3 2.6 Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
139451799 192618 0 None -3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 279 5 1 5 1.9 COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
CHEMBL4867553 192618 0 None -3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 279 5 1 5 1.9 COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
7922 8737 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 10.1016/j.bmc.2008.08.052
9798456 8737 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 10.1016/j.bmc.2008.08.052
CHEMBL476131 8737 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 10.1016/j.bmc.2008.08.052
23658144 164958 1 None 100 2 Human 9.1 pEC50 = 9.1 Functional
Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
CHEMBL4087633 164958 1 None 100 2 Human 9.1 pEC50 = 9.1 Functional
Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
137642160 165171 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 308 5 1 5 1.3 COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4089965 165171 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 308 5 1 5 1.3 COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 10.1016/j.ejmech.2016.12.013
1357 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
1672 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
224 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
896 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
CHEMBL45 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
DB01065 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
1357 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
1672 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
224 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
896 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
CHEMBL45 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
DB01065 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
1357 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
1672 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
224 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
896 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
CHEMBL45 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
DB01065 9263 139 None -1 5 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
139451790 192075 18 None -6 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 297 5 1 5 1.8 COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4859295 192075 18 None -6 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 297 5 1 5 1.8 COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O 10.1021/acs.jmedchem.0c00627
145981162 173276 0 None 2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 270 3 2 2 2.5 COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4278575 173276 0 None 2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 270 3 2 2 2.5 COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 10.1016/j.ejmech.2017.10.025
127026427 144462 0 None 1 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758679 144462 0 None 1 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
127026062 144467 0 None 7 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758717 144467 0 None 7 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 10.1016/j.ejmech.2015.12.047
145982167 173390 0 None 3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 305 4 1 3 2.4 COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4280601 173390 0 None 3 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 305 4 1 3 2.4 COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 10.1016/j.ejmech.2017.10.025
12985491 193759 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 411 6 1 2 5.1 COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL490595 193759 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 411 6 1 2 5.1 COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
137637884 163025 0 None 19 2 Human 9.0 pEC50 = 9 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 280 3 1 2 3.3 CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4064813 163025 0 None 19 2 Human 9.0 pEC50 = 9 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 280 3 1 2 3.3 CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
21581654 67526 1 None 10 2 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760944 67526 1 None 10 2 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
127025784 144511 0 None 8 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759084 144511 0 None 8 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 10.1016/j.ejmech.2015.12.047
137650826 164284 0 None 28 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 289 5 2 3 2.3 CCNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4079699 164284 0 None 28 2 Human 9.0 pEC50 = 9.0 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 289 5 2 3 2.3 CCNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
23658146 163897 1 None 15 2 Human 8.9 pEC50 = 8.9 Functional
Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
CHEMBL4074895 163897 1 None 15 2 Human 8.9 pEC50 = 8.9 Functional
Partial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
11784134 113726 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 391 6 1 3 4.7 COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL314947 113726 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 391 6 1 3 4.7 COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
168274836 196926 0 None -17 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5173623 196926 0 None -17 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
52918080 67538 0 None 12 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 287 4 1 4 2.1 COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 10.1016/j.bmcl.2011.02.097
CHEMBL1760957 67538 0 None 12 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 287 4 1 4 2.1 COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 10.1016/j.bmcl.2011.02.097
1354 10209 15 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 10.1016/j.bmc.2008.08.052
22133318 10209 15 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 10.1016/j.bmc.2008.08.052
CHEMBL490188 10209 15 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 10.1016/j.bmc.2008.08.052
44579259 193893 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 347 6 1 3 4.0 COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL491604 193893 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 347 6 1 3 4.0 COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
53238181 7721 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 10.1021/jm200221q
7780 7721 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 10.1021/jm200221q
CHEMBL1774519 7721 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
ChEMBL 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 10.1021/jm200221q
52918078 67528 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 247 5 1 4 1.6 CCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
CHEMBL1760946 67528 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 247 5 1 4 1.6 CCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
127029516 144412 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758225 144412 0 None 3 2 Human 8.9 pEC50 = 8.9 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
44579163 188908 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 362 6 1 3 4.3 COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL478217 188908 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 362 6 1 3 4.3 COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
54582195 67536 0 None 9 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 329 5 1 5 1.9 COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760955 67536 0 None 9 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 329 5 1 5 1.9 COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
127025787 144510 0 None - 1 Human 8.0 pEC50 = 8 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 298 4 2 3 3.4 CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
CHEMBL3759080 144510 0 None - 1 Human 8.0 pEC50 = 8 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 298 4 2 3 3.4 CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
137653199 165402 0 None - 1 Human 8.0 pEC50 = 8 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 218 2 1 2 1.4 CC(=O)NCC1Cc2ccccc2N(C)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4092308 165402 0 None - 1 Human 8.0 pEC50 = 8 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 218 2 1 2 1.4 CC(=O)NCC1Cc2ccccc2N(C)C1 10.1021/acs.jmedchem.8b00359
10925526 119111 0 None 47 2 Human 8.0 pEC50 = 8 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 329 6 1 3 4.2 COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL329299 119111 0 None 47 2 Human 8.0 pEC50 = 8 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 329 6 1 3 4.2 COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
145991111 173691 0 None 10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 319 5 1 3 2.8 CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4286494 173691 0 None 10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 319 5 1 3 2.8 CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
122178510 128108 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 275 4 2 4 3.0 COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580921 128108 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 275 4 2 4 3.0 COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 10.1021/acs.jmedchem.5b00245
54581170 67537 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 359 4 1 4 1.8 COc1ccc2c(I)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760956 67537 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 359 4 1 4 1.8 COc1ccc2c(I)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
86273228 128098 0 None 18 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 258 6 2 2 2.4 C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580910 128098 0 None 18 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 258 6 2 2 2.4 C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
122178513 128111 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 288 5 2 5 3.1 CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 10.1021/acs.jmedchem.5b00245
CHEMBL3580926 128111 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 288 5 2 5 3.1 CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 10.1021/acs.jmedchem.5b00245
145 6928 49 None -63 11 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
1832 6928 49 None -63 11 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
CHEMBL7257 6928 49 None -63 11 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
DB14010 6928 49 None -63 11 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
49862736 21909 0 None -117 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 569 3 0 4 6.9 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209787 21909 0 None -117 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 569 3 0 4 6.9 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
162663385 188777 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 271 5 1 4 1.7 COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4780509 188777 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 271 5 1 4 1.7 COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2020.112078
86273229 128097 1 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 244 5 2 2 2.0 C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580909 128097 1 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 244 5 2 2 2.0 C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
9850873 15639 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 564 15 2 4 6.4 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 10.1016/j.bmc.2010.04.008
CHEMBL1097314 15639 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 564 15 2 4 6.4 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 10.1016/j.bmc.2010.04.008
44359437 36673 0 None -3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 5 2 3 2.1 COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 10.1039/C4MD00149D
CHEMBL138807 36673 0 None -3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 5 2 3 2.1 COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 10.1039/C4MD00149D
81689735 128103 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay
ChEMBL 257 4 1 4 2.7 COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580916 128103 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay
ChEMBL 257 4 1 4 2.7 COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
46845151 15438 0 None -7 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 499 12 2 4 6.1 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095505 15438 0 None -7 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 499 12 2 4 6.1 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 10.1016/j.bmc.2010.04.008
46919520 21910 0 None -1479 6 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 597 4 0 5 6.3 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209788 21910 0 None -1479 6 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 597 4 0 5 6.3 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
11078652 214697 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 351 7 1 3 4.3 CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL96778 214697 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsIntrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
ChEMBL 351 7 1 3 4.3 CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
168274836 196926 0 None -17 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5173623 196926 0 None -17 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
145986700 173998 0 None 5 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 328 4 2 2 3.5 CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4292109 173998 0 None 5 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 328 4 2 2 3.5 CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
139451776 191790 0 None -3 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 277 6 1 5 1.6 COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
CHEMBL4854836 191790 0 None -3 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 277 6 1 5 1.6 COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
52918077 67527 2 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 233 4 1 4 1.2 COc1ccc2ccn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760945 67527 2 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 233 4 1 4 1.2 COc1ccc2ccn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
52953165 69182 0 None 87 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 389 7 1 3 5.6 C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779810 69182 0 None 87 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 389 7 1 3 5.6 C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
9818487 180312 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 319 5 1 2 4.2 COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL453138 180312 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 319 5 1 2 4.2 COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
10266979 105795 0 None 99 2 Human 8.6 pEC50 = 8.6 Functional
Effective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assayEffective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assay
ChEMBL 303 3 1 3 2.0 CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL280142 105795 0 None 99 2 Human 8.6 pEC50 = 8.6 Functional
Effective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assayEffective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assay
ChEMBL 303 3 1 3 2.0 CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
139451784 192174 0 None 1 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 317 7 1 5 2.4 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 10.1021/acs.jmedchem.0c00627
CHEMBL4860729 192174 0 None 1 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodAgonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method
ChEMBL 317 7 1 5 2.4 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 10.1021/acs.jmedchem.0c00627
23642306 165852 1 None 17 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 6 2 3 2.5 CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
CHEMBL4097233 165852 1 None 17 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 6 2 3 2.5 CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
145993566 174150 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 312 5 2 2 3.6 CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4294790 174150 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 312 5 2 2 3.6 CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
18360658 15662 0 None -10 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 518 13 2 5 5.7 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1097497 15662 0 None -10 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 518 13 2 5 5.7 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
44394435 73701 0 None -34 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulation
ChEMBL 361 8 1 2 5.2 CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL186586 73701 0 None -34 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulation
ChEMBL 361 8 1 2 5.2 CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
49862664 21895 0 None -60 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 513 3 1 4 5.4 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209706 21895 0 None -60 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 513 3 1 4 5.4 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
162649850 186917 0 None 2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4748822 186917 0 None 2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
162644724 186173 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 321 5 1 4 3.0 COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4739898 186173 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 321 5 1 4 3.0 COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
162656758 187701 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4757920 187701 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
162668689 189537 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 285 5 1 4 2.2 COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4790145 189537 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 285 5 1 4 2.2 COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
1357 9263 139 None -1 5 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2019.06.008
1672 9263 139 None -1 5 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2019.06.008
224 9263 139 None -1 5 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2019.06.008
896 9263 139 None -1 5 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2019.06.008
CHEMBL45 9263 139 None -1 5 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2019.06.008
DB01065 9263 139 None -1 5 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2019.06.008
23658143 163156 1 None 41 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
CHEMBL4066279 163156 1 None 41 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
10163052 15293 0 None -10 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 483 12 2 4 5.9 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1094212 15293 0 None -10 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 483 12 2 4 5.9 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 10.1016/j.bmc.2010.04.008
122178509 128106 0 None 9 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580919 128106 0 None 9 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
86273222 128101 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580913 128101 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 10.1021/acs.jmedchem.5b00245
49862738 21912 0 None -36 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 555 4 0 4 6.5 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209790 21912 0 None -36 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 555 4 0 4 6.5 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
145982333 173336 0 None 2 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4279639 173336 0 None 2 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145979689 173402 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 314 3 2 2 3.1 CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4280791 173402 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 314 3 2 2 3.1 CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145987794 173899 0 None 6 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 298 4 2 2 3.2 CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4290302 173899 0 None 6 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 298 4 2 2 3.2 CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
86273226 128096 0 None 12 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 256 5 2 2 1.9 C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580908 128096 0 None 12 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 256 5 2 2 1.9 C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
137645887 164719 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 294 4 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4084568 164719 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 294 4 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
127026426 144578 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759606 144578 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
127025783 144516 0 None 8 2 Human 8.5 pEC50 = 8.5 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759160 144516 0 None 8 2 Human 8.5 pEC50 = 8.5 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 10.1016/j.ejmech.2015.12.047
162647716 186666 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4745789 186666 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
168296374 199297 0 None -9 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
CHEMBL5209359 199297 0 None -9 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
49862665 21896 0 None -128 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 585 5 1 5 5.9 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209707 21896 0 None -128 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 585 5 1 5 5.9 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
19703063 35688 1 None -1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 233 4 2 3 1.2 COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 10.1016/j.bmcl.2011.02.097
CHEMBL137969 35688 1 None -1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 233 4 2 3 1.2 COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 10.1016/j.bmcl.2011.02.097
145992795 173570 0 None 25 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 342 5 2 2 3.9 CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4284223 173570 0 None 25 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 342 5 2 2 3.9 CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
9937825 15640 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 564 17 2 4 6.7 C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1097315 15640 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 564 17 2 4 6.7 C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 10.1016/j.bmc.2010.04.008
1355 10211 5 None -5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1016/j.bmc.2010.04.008
9806449 10211 5 None -5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1016/j.bmc.2010.04.008
CHEMBL14453 10211 5 None -5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1016/j.bmc.2010.04.008
162658247 187797 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2cnnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4759137 187797 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2cnnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
122178508 128104 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 243 4 1 4 2.3 COc1ccc2[nH]cc(CCc3nnco3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580917 128104 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 243 4 1 4 2.3 COc1ccc2[nH]cc(CCc3nnco3)c2c1 10.1021/acs.jmedchem.5b00245
49862739 21913 0 None -23 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 583 6 0 4 7.3 CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 10.1016/j.bmcl.2010.06.068
CHEMBL1209791 21913 0 None -23 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 583 6 0 4 7.3 CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 10.1016/j.bmcl.2010.06.068
9064 111996 94 None -2 4 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader
ChEMBL 290 1 5 6 1.5 Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 10.1016/j.ejmech.2020.112960
CHEMBL311498 111996 94 None -2 4 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT2R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader
ChEMBL 290 1 5 6 1.5 Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 10.1016/j.ejmech.2020.112960
145991966 173615 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 285 3 1 3 3.2 COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4285145 173615 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 285 3 1 3 3.2 COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145986330 173836 0 None 3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 286 3 2 2 2.7 COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4289115 173836 0 None 3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 286 3 2 2 2.7 COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 10.1016/j.ejmech.2017.10.025
122178509 128106 0 None 9 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580919 128106 0 None 9 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayAgonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
127025781 144602 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759859 144602 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
145983175 173210 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 314 4 2 2 3.4 CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4277390 173210 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 314 4 2 2 3.4 CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
86273470 128100 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 256 4 1 3 3.3 COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580912 128100 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 256 4 1 3 3.3 COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
162649247 186854 0 None -1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 351 6 1 5 3.0 COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 10.1016/j.ejmech.2020.112078
CHEMBL4747996 186854 0 None -1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 351 6 1 5 3.0 COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 10.1016/j.ejmech.2020.112078
145979282 173454 0 None 1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4281915 173454 0 None 1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
127025786 144627 0 None 12 2 Human 8.2 pEC50 = 8.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 312 5 2 3 3.5 CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 10.1016/j.ejmech.2015.12.047
CHEMBL3760044 144627 0 None 12 2 Human 8.2 pEC50 = 8.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 312 5 2 3 3.5 CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 10.1016/j.ejmech.2015.12.047
49862740 21914 0 None -10 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 585 6 0 5 6.1 COCC(C)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 10.1016/j.bmcl.2010.06.068
CHEMBL1209792 21914 0 None -10 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 585 6 0 5 6.1 COCC(C)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 10.1016/j.bmcl.2010.06.068
137636079 163006 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 232 3 1 2 1.8 CCN1CC(CNC(C)=O)Cc2ccccc21 10.1021/acs.jmedchem.8b00359
CHEMBL4064626 163006 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 232 3 1 2 1.8 CCN1CC(CNC(C)=O)Cc2ccccc21 10.1021/acs.jmedchem.8b00359
11351216 69178 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 441 6 1 3 5.4 O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779807 69178 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 441 6 1 3 5.4 O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
23658145 164242 1 None 52 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
CHEMBL4079214 164242 1 None 52 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
4018512 49994 42 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 308 5 2 2 3.5 COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1039/d2md00156j
CHEMBL15060 49994 42 None 2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 308 5 2 2 3.5 COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1039/d2md00156j
122178507 128102 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580915 128102 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
49862737 21911 0 None -10 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 611 5 0 5 6.5 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209789 21911 0 None -10 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP releaseAgonist activity at melatonin receptor type 1B expressed in CHO cells assessed as cAMP release
ChEMBL 611 5 0 5 6.5 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
127025782 144509 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 297 4 1 3 3.9 COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759054 144509 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 297 4 1 3 3.9 COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 10.1016/j.ejmech.2015.12.047
127026425 144598 0 None -8 2 Human 8.1 pEC50 = 8.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759816 144598 0 None -8 2 Human 8.1 pEC50 = 8.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
137656715 166326 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 308 5 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4102517 166326 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
ChEMBL 308 5 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
86273227 128095 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 242 4 2 2 1.5 C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580907 128095 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 242 4 2 2 1.5 C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
86079062 187511 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2ncnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4755860 187511 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2ncnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
46888522 15417 0 None -3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 513 12 1 5 6.2 COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 10.1016/j.bmc.2010.04.008
CHEMBL1095197 15417 0 None -3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
ChEMBL 513 12 1 5 6.2 COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 10.1016/j.bmc.2010.04.008
81689735 128103 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 257 4 1 4 2.7 COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580916 128103 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
ChEMBL 257 4 1 4 2.7 COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
198 7101 126 None 3 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/d2md00156j
82148 7101 126 None 3 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/d2md00156j
99 7101 126 None 3 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/d2md00156j
CHEMBL10878 7101 126 None 3 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/d2md00156j
DB06594 7101 126 None 3 4 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/d2md00156j
162661094 188222 3 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4764211 188222 3 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
164946945 197008 1 None 3 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5174929 197008 1 None 3 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
44396074 73927 2 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation
ChEMBL 339 5 0 3 3.8 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 10.1021/jm401343c
CHEMBL187593 73927 2 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation
ChEMBL 339 5 0 3 3.8 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 10.1021/jm401343c
9909783 73910 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation
ChEMBL 415 6 0 3 5.4 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1021/jm401343c
CHEMBL187525 73910 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationAntagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulation
ChEMBL 415 6 0 3 5.4 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1021/jm401343c
16094585 89665 0 None - 0 Human 9.4 pKd = 9.4 Functional
Activity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS bindingActivity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS binding
ChEMBL 321 6 1 2 4.0 COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm060850a
CHEMBL218065 89665 0 None - 0 Human 9.4 pKd = 9.4 Functional
Activity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS bindingActivity at human MT2 receptor expressed in NIH3T3 cells assessed as inhibition of MLT-stimulated [35S]GTPgammaS binding
ChEMBL 321 6 1 2 4.0 COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm060850a
90655902 117644 0 None - 0 Human 9.5 pKi = 9.5 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 330 5 2 4 2.5 CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3 10.1021/jm401343c
CHEMBL3260982 117644 0 None - 0 Human 9.5 pKi = 9.5 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 330 5 2 4 2.5 CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3 10.1021/jm401343c
52918077 67527 2 None 1 2 Human 9.2 pKi = 9.2 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay
ChEMBL 233 4 1 4 1.2 COc1ccc2ccn(CCNC(C)=O)c2n1 10.1021/jm401343c
CHEMBL1760945 67527 2 None 1 2 Human 9.2 pKi = 9.2 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay
ChEMBL 233 4 1 4 1.2 COc1ccc2ccn(CCNC(C)=O)c2n1 10.1021/jm401343c
11185529 10686 5 None - 0 Human 8.9 pKi = 8.9 Functional
Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm401343c
7772 10686 5 None - 0 Human 8.9 pKi = 8.9 Functional
Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm401343c
CHEMBL189449 10686 5 None - 0 Human 8.9 pKi = 8.9 Functional
Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm401343c
24763223 7004 0 None - 0 Human 7.0 pKi = 7.0 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 340 10 1 3 3.7 CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C 10.1021/jm401343c
8289 7004 0 None - 0 Human 7.0 pKi = 7.0 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 340 10 1 3 3.7 CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C 10.1021/jm401343c
CHEMBL3260987 7004 0 None - 0 Human 7.0 pKi = 7.0 Functional
Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 340 10 1 3 3.7 CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C 10.1021/jm401343c
1357 9263 139 None -1 5 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 None -1 5 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 None -1 5 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 None -1 5 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 None -1 5 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 None -1 5 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
10666 10692 0 None -21 2 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 362 4 2 3 4.5 Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1 32040955
138993662 10692 0 None -21 2 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 362 4 2 3 4.5 Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1 32040955
10665 10690 0 None -50 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 3 4.2 CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C 32040955
137977202 10690 0 None -50 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 3 4.2 CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C 32040955
103828029 10691 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 292 4 1 3 3.5 COc1ccc(c(c1)CNc1cccnc1)Br 32040955
10667 10691 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 292 4 1 3 3.5 COc1ccc(c(c1)CNc1cccnc1)Br 32040955


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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10440 9458 20 None -3 3 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay
ChEMBL 417 7 3 7 4.2 OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F 10.1021/acs.jmedchem.9b00869
139030523 9458 20 None -3 3 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay
ChEMBL 417 7 3 7 4.2 OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F 10.1021/acs.jmedchem.9b00869
CHEMBL4449712 9458 20 None -3 3 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay
ChEMBL 417 7 3 7 4.2 OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F 10.1021/acs.jmedchem.9b00869
23634404 132628 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 3.1 CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648359 132628 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 3.1 CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 nan
57781211 132630 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 376 8 1 3 4.9 CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21 nan
CHEMBL3648361 132630 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 376 8 1 3 4.9 CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21 nan
23725569 132632 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 3 1 3 3.2 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21 nan
CHEMBL3648363 132632 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 3 1 3 3.2 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21 nan
57781216 132625 0 None -2 2 Human 9.9 pIC50 = 9.9 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648356 132625 0 None -2 2 Human 9.9 pIC50 = 9.9 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 nan
57781258 132638 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 312 3 1 3 3.2 Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3 nan
CHEMBL3648369 132638 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 312 3 1 3 3.2 Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3 nan
57781244 167612 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 270 3 1 3 3.0 CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 nan
CHEMBL4114700 167612 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 270 3 1 3 3.0 CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 nan
57781280 167743 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 2 1 3 3.1 CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21 nan
CHEMBL4115681 167743 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 2 1 3 3.1 CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21 nan
23725512 132622 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 256 3 1 3 2.6 CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648350 132622 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 256 3 1 3 2.6 CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21 nan
23725514 132627 0 None -1 2 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 3.1 CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648358 132627 0 None -1 2 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 3.1 CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 nan
23725567 132631 0 None -2 2 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 3 1 3 3.2 CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 nan
CHEMBL3648362 132631 0 None -2 2 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 3 1 3 3.2 CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 nan
23725612 132636 0 None 2 2 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 4 1 4 2.4 COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 nan
CHEMBL3648367 132636 0 None 2 2 Human 9.6 pIC50 = 9.6 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 4 1 4 2.4 COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 nan
1357 9263 139 None 1 9 Human 9.5 pIC50 = 9.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/s0960-894x(03)00090-8
1672 9263 139 None 1 9 Human 9.5 pIC50 = 9.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/s0960-894x(03)00090-8
224 9263 139 None 1 9 Human 9.5 pIC50 = 9.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/s0960-894x(03)00090-8
896 9263 139 None 1 9 Human 9.5 pIC50 = 9.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/s0960-894x(03)00090-8
CHEMBL45 9263 139 None 1 9 Human 9.5 pIC50 = 9.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/s0960-894x(03)00090-8
DB01065 9263 139 None 1 9 Human 9.5 pIC50 = 9.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/s0960-894x(03)00090-8
57781227 132623 0 None 6 2 Human 9.5 pIC50 = 9.5 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 244 3 1 3 2.4 CC(=O)NCCC1CCc2ccc3ncoc3c21 nan
CHEMBL3648354 132623 0 None 6 2 Human 9.5 pIC50 = 9.5 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 244 3 1 3 2.4 CC(=O)NCCC1CCc2ccc3ncoc3c21 nan
23725565 132624 0 None -1 2 Human 9.5 pIC50 = 9.5 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 258 3 1 3 2.7 CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648355 132624 0 None -1 2 Human 9.5 pIC50 = 9.5 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 258 3 1 3 2.7 CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 nan
57781268 167609 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 256 2 1 3 2.6 CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 nan
CHEMBL4114658 167609 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 256 2 1 3 2.6 CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 nan
23725515 132634 0 None 1 2 Human 9.4 pIC50 = 9.4 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 2.9 CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 nan
CHEMBL3648365 132634 0 None 1 2 Human 9.4 pIC50 = 9.4 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 2.9 CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 nan
57781262 167615 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 374 7 1 3 4.9 CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21 nan
CHEMBL4114715 167615 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 374 7 1 3 4.9 CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21 nan
1357 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.010
1672 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.010
224 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.010
896 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.010
CHEMBL45 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.010
DB01065 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.010
1357 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.03.036
1672 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.03.036
224 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.03.036
896 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.03.036
CHEMBL45 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.03.036
DB01065 9263 139 None 1 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.03.036
10059864 116600 5 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.03.036
CHEMBL323332 116600 5 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.03.036
57781246 132635 0 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 284 4 1 3 3.3 CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 nan
CHEMBL3648366 132635 0 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 284 4 1 3 3.3 CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 nan
57781261 132637 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 284 4 1 3 3.1 Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3 nan
CHEMBL3648368 132637 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 284 4 1 3 3.1 Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3 nan
9859969 181802 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 259 4 1 2 3.2 CSc1ccc2cccc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2011.02.010
CHEMBL456727 181802 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 259 4 1 2 3.2 CSc1ccc2cccc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2011.02.010
22375372 74032 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 302 3 0 3 2.5 COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2 10.1016/s0960-894x(03)00090-8
CHEMBL18808 74032 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 302 3 0 3 2.5 COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2 10.1016/s0960-894x(03)00090-8
44272486 76603 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 302 3 0 3 2.5 COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2 10.1016/s0960-894x(03)00090-8
CHEMBL19374 76603 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 302 3 0 3 2.5 COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2 10.1016/s0960-894x(03)00090-8
44272591 78480 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 300 3 0 3 2.2 COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2 10.1016/s0960-894x(03)00090-8
CHEMBL19653 78480 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 300 3 0 3 2.2 COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2 10.1016/s0960-894x(03)00090-8
10266979 105795 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 303 3 1 3 2.0 CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL280142 105795 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 303 3 1 3 2.0 CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
11213541 134282 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 469 6 0 3 5.9 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C(F)(F)F)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL366115 134282 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 469 6 0 3 5.9 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C(F)(F)F)CC2 10.1016/j.bmcl.2004.09.024
10198772 199862 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 246 4 2 3 1.2 CC(=O)NCCc1coc2ccc(C(N)=O)cc12 10.1016/j.bmc.2008.03.036
CHEMBL522528 199862 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 246 4 2 3 1.2 CC(=O)NCCc1coc2ccc(C(N)=O)cc12 10.1016/j.bmc.2008.03.036
44396113 73616 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 469 6 0 3 6.1 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL186167 73616 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 469 6 0 3 6.1 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 10.1016/j.bmcl.2004.09.024
44272252 105498 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 316 5 0 3 3.0 CCCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL277828 105498 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 316 5 0 3 3.0 CCCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
11784859 130073 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 477 7 0 3 6.7 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccccc1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL361458 130073 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 477 7 0 3 6.7 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccccc1)CC2 10.1016/j.bmcl.2004.09.024
44396149 73773 4 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 355 4 0 1 5.4 CC(=O)N1CCc2ccccc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL186915 73773 4 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 355 4 0 1 5.4 CC(=O)N1CCc2ccccc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
44395896 73638 3 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 373 4 0 1 5.5 CC(=O)N1CCc2cc(F)ccc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL186251 73638 3 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 373 4 0 1 5.5 CC(=O)N1CCc2cc(F)ccc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
46919520 21910 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human melatonin receptor type 1BInhibition of human melatonin receptor type 1B
ChEMBL 597 4 0 5 6.3 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
CHEMBL1209788 21910 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human melatonin receptor type 1BInhibition of human melatonin receptor type 1B
ChEMBL 597 4 0 5 6.3 Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N 10.1016/j.bmcl.2010.06.068
44396148 73763 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 340 5 1 3 3.3 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(N)=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL186866 73763 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 340 5 1 3 3.3 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(N)=O)CC2 10.1016/j.bmcl.2004.09.024
22375370 74788 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 302 4 0 3 2.6 CCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL19123 74788 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 302 4 0 3 2.6 CCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
18175057 194174 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 314 4 2 3 2.6 CC(=O)NCCc1coc2ccc(NC(=O)C(F)(F)F)cc12 10.1016/j.bmc.2008.03.036
CHEMBL493607 194174 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 314 4 2 3 2.6 CC(=O)NCCc1coc2ccc(NC(=O)C(F)(F)F)cc12 10.1016/j.bmc.2008.03.036
11430378 174998 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 431 6 0 4 5.6 COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL433573 174998 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 431 6 0 4 5.6 COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
44396058 73823 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 407 6 0 3 5.3 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCCCC1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL187148 73823 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 407 6 0 3 5.3 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCCCC1)CC2 10.1016/j.bmcl.2004.09.024
44272451 74425 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 294 4 0 3 2.1 COc1ccc(F)c(CN2CCN(C(=O)C(C)C)CC2)c1 10.1016/s0960-894x(03)00090-8
CHEMBL19061 74425 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 294 4 0 3 2.1 COc1ccc(F)c(CN2CCN(C(=O)C(C)C)CC2)c1 10.1016/s0960-894x(03)00090-8
11178762 73780 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 463 5 0 2 6.1 COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL186941 73780 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 463 5 0 2 6.1 COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
44396057 133870 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 379 6 0 3 4.6 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCC1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL365648 133870 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 379 6 0 3 4.6 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCC1)CC2 10.1016/j.bmcl.2004.09.024
44396034 134081 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 455 7 0 3 6.2 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL365899 134081 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 455 7 0 3 6.2 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 10.1016/j.bmcl.2004.09.024
17957000 68179 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 286 4 2 3 2.7 COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2011.02.010
CHEMBL1770214 68179 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 286 4 2 3 2.7 COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2011.02.010
44272539 73898 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 292 4 0 3 1.9 COc1ccc(F)c(CN2CCN(C(=O)C3CC3)CC2)c1 10.1016/s0960-894x(03)00090-8
CHEMBL18747 73898 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 292 4 0 3 1.9 COc1ccc(F)c(CN2CCN(C(=O)C3CC3)CC2)c1 10.1016/s0960-894x(03)00090-8
44396136 175203 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 385 5 0 2 5.4 COc1ccc2c(c1)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL434916 175203 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 385 5 0 2 5.4 COc1ccc2c(c1)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
44395939 130463 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 471 10 0 3 6.9 CCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL362162 130463 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 471 10 0 3 6.9 CCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
22375366 76268 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 300 3 0 3 2.2 COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2 10.1016/s0960-894x(03)00090-8
CHEMBL19339 76268 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 300 3 0 3 2.2 COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2 10.1016/s0960-894x(03)00090-8
22375392 105958 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 303 3 1 3 2.0 CCNC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL281345 105958 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 303 3 1 3 2.0 CCNC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
11247050 73641 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 416 6 1 3 4.9 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(N)=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL186262 73641 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 416 6 1 3 4.9 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(N)=O)CC2 10.1016/j.bmcl.2004.09.024
44396034 134081 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 455 7 0 3 6.2 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL365899 134081 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 455 7 0 3 6.2 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 10.1016/j.bmcl.2004.09.024
22375417 74038 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 288 3 0 3 2.2 CCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL18810 74038 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 288 3 0 3 2.2 CCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
44395994 73511 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 483 7 0 3 6.9 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCCCC1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL185733 73511 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 483 7 0 3 6.9 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCCCC1)CC2 10.1016/j.bmcl.2004.09.024
18175008 182274 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 292 4 2 3 1.2 CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12 10.1016/j.ejmech.2011.02.010
CHEMBL457763 182274 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 292 4 2 3 1.2 CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12 10.1016/j.ejmech.2011.02.010
9861677 194338 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 315 5 1 4 3.1 COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1 10.1016/j.bmc.2008.03.036
CHEMBL494566 194338 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 315 5 1 4 3.1 COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1 10.1016/j.bmc.2008.03.036
44396073 73926 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 485 11 0 3 7.3 CCCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL187592 73926 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 485 11 0 3 7.3 CCCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
4284525 195493 42 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 275 4 3 3 2.0 COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2011.02.010
CHEMBL504585 195493 42 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 275 4 3 3 2.0 COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2011.02.010
4284525 195493 42 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 275 4 3 3 2.0 COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.03.036
CHEMBL504585 195493 42 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 275 4 3 3 2.0 COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.03.036
22037991 105447 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 274 2 0 3 1.8 COc1ccc2c(c1)C(N1CCN(C(C)=O)CC1)CC2 10.1016/s0960-894x(03)00090-8
CHEMBL277429 105447 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 274 2 0 3 1.8 COc1ccc2c(c1)C(N1CCN(C(C)=O)CC1)CC2 10.1016/s0960-894x(03)00090-8
44395915 73820 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 415 6 0 3 5.4 COc1cc2c(c(OC)c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL187136 73820 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 415 6 0 3 5.4 COc1cc2c(c(OC)c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
17957007 199434 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 304 5 2 4 2.9 COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1 10.1016/j.bmc.2008.03.036
CHEMBL521826 199434 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 304 5 2 4 2.9 COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1 10.1016/j.bmc.2008.03.036
9064 111996 94 None - 0 Human 4.3 pIC50 = 4.3 Binding
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cellsAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells
ChEMBL 290 1 5 6 1.5 Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 10.1016/j.bmc.2021.116270
CHEMBL311498 111996 94 None - 0 Human 4.3 pIC50 = 4.3 Binding
Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cellsAgonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells
ChEMBL 290 1 5 6 1.5 Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 10.1016/j.bmc.2021.116270
11749479 73672 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 385 5 0 2 5.4 COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL186452 73672 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 385 5 0 2 5.4 COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
44576406 194149 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 330 5 2 4 3.5 COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1 10.1016/j.bmc.2008.03.036
CHEMBL493414 194149 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 330 5 2 4 3.5 COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1 10.1016/j.bmc.2008.03.036
44593610 194151 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 302 6 2 4 2.8 C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12 10.1016/j.bmc.2008.03.036
CHEMBL493424 194151 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 302 6 2 4 2.8 C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12 10.1016/j.bmc.2008.03.036
25014882 194474 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 302 5 2 4 2.7 COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1 10.1016/j.bmc.2008.03.036
CHEMBL495232 194474 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 302 5 2 4 2.7 COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1 10.1016/j.bmc.2008.03.036
23725566 132629 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 3.1 CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648360 132629 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 272 4 1 3 3.1 CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 nan
53827707 117643 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 279 6 1 3 3.0 CCCNC(=O)CCCc1cccc2c1SCCO2 10.1021/jm401343c
CHEMBL3260981 117643 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 279 6 1 3 3.0 CCCNC(=O)CCCc1cccc2c1SCCO2 10.1021/jm401343c
11304981 73702 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 430 6 1 3 5.2 CNC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL186590 73702 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 430 6 1 3 5.2 CNC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
11304958 74040 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 429 7 0 3 5.8 CCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL188120 74040 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 429 7 0 3 5.8 CCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
18175032 182375 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 358 6 2 4 2.3 CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1 10.1016/j.ejmech.2011.02.010
CHEMBL457992 182375 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 358 6 2 4 2.3 CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1 10.1016/j.ejmech.2011.02.010
22375402 105133 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 314 3 0 3 2.6 COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CCC2 10.1016/s0960-894x(03)00090-8
CHEMBL275205 105133 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 314 3 0 3 2.6 COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CCC2 10.1016/s0960-894x(03)00090-8
44396074 73927 2 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 339 5 0 3 3.8 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL187593 73927 2 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 339 5 0 3 3.8 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
11476283 73671 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 443 8 0 3 6.2 CCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
CHEMBL186451 73671 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 443 8 0 3 6.2 CCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.09.024
23725568 132633 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 3 1 3 3.2 CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21 nan
CHEMBL3648364 132633 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 274 3 1 3 3.2 CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21 nan
44396100 128826 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 545 7 0 3 7.7 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL359576 128826 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 545 7 0 3 7.7 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 10.1016/j.bmcl.2004.09.024
10663827 129705 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 325 6 0 3 3.4 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL360641 129705 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 325 6 0 3 3.4 COc1cc2c(cc1OC)C(CCc1ccccc1)N(C=O)CC2 10.1016/j.bmcl.2004.09.024
21916760 182478 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 291 4 1 3 1.9 CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12 10.1016/j.ejmech.2011.02.010
CHEMBL458209 182478 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 291 4 1 3 1.9 CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12 10.1016/j.ejmech.2011.02.010
23725513 132626 0 None 3 2 Human 8.0 pIC50 = 8.0 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 nan
CHEMBL3648357 132626 0 None 3 2 Human 8.0 pIC50 = 8.0 Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 nan
9909783 73910 0 None - 1 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 415 6 0 3 5.4 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL187525 73910 0 None - 1 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 415 6 0 3 5.4 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1016/j.bmcl.2004.09.024
11361621 132585 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 401 7 0 3 5.0 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2 10.1016/j.bmcl.2004.09.024
CHEMBL364816 132585 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory concentration against Melatonin receptor type 1BInhibitory concentration against Melatonin receptor type 1B
ChEMBL 401 7 0 3 5.0 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2 10.1016/j.bmcl.2004.09.024
44272521 77088 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 310 3 0 3 2.9 COc1ccc2cccc(N3CCN(C(=O)C4CC4)CC3)c2c1 10.1016/s0960-894x(03)00090-8
CHEMBL19442 77088 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 310 3 0 3 2.9 COc1ccc2cccc(N3CCN(C(=O)C4CC4)CC3)c2c1 10.1016/s0960-894x(03)00090-8
22375407 77413 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 317 3 1 3 2.4 CCNC(=O)N1CCN(C2CCCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
CHEMBL19503 77413 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro receptor binding at MT2 (Melatonin) receptor.In vitro receptor binding at MT2 (Melatonin) receptor.
ChEMBL 317 3 1 3 2.4 CCNC(=O)N1CCN(C2CCCc3ccc(OC)cc32)CC1 10.1016/s0960-894x(03)00090-8
9817006 181763 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 275 4 1 2 2.3 CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12 10.1016/j.ejmech.2011.02.010
CHEMBL456646 181763 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human MT2 receptorBinding affinity to human MT2 receptor
ChEMBL 275 4 1 2 2.3 CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12 10.1016/j.ejmech.2011.02.010
1357 9263 139 None 1 9 Human 9.8 pKd = 9.8 Binding
Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
1672 9263 139 None 1 9 Human 9.8 pKd = 9.8 Binding
Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
224 9263 139 None 1 9 Human 9.8 pKd = 9.8 Binding
Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
896 9263 139 None 1 9 Human 9.8 pKd = 9.8 Binding
Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
CHEMBL45 9263 139 None 1 9 Human 9.8 pKd = 9.8 Binding
Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
DB01065 9263 139 None 1 9 Human 9.8 pKd = 9.8 Binding
Binding affinity to melatonin receptor MT2 (unknown origin)Binding affinity to melatonin receptor MT2 (unknown origin)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
10440 9458 20 None -3 3 Human 6.0 pKd = 6.0 Binding
Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay
ChEMBL 417 7 3 7 4.2 OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F 10.1021/acs.jmedchem.9b00869
139030523 9458 20 None -3 3 Human 6.0 pKd = 6.0 Binding
Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay
ChEMBL 417 7 3 7 4.2 OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F 10.1021/acs.jmedchem.9b00869
CHEMBL4449712 9458 20 None -3 3 Human 6.0 pKd = 6.0 Binding
Agonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT2 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay
ChEMBL 417 7 3 7 4.2 OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F 10.1021/acs.jmedchem.9b00869
11723593 113655 0 None 1 2 Human 11.0 pKi = 11 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 321 6 1 3 4.0 C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL314512 113655 0 None 1 2 Human 11.0 pKi = 11 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 321 6 1 3 4.0 C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
53237949 68791 0 None 3 2 Human 11.0 pKi = 11 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 339 4 1 2 3.7 CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1 10.1021/jm200221q
CHEMBL1774516 68791 0 None 3 2 Human 11.0 pKi = 11 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 339 4 1 2 3.7 CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1 10.1021/jm200221q
53237947 68789 0 None 1 2 Human 11.0 pKi = 11.0 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 299 5 1 2 3.5 CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774514 68789 0 None 1 2 Human 11.0 pKi = 11.0 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 299 5 1 2 3.5 CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
53238410 68802 0 None 1174 2 Human 11.0 pKi = 11.0 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 361 5 1 2 4.7 CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774529 68802 0 None 1174 2 Human 11.0 pKi = 11.0 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 361 5 1 2 4.7 CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
53238181 7721 0 None 741 2 Human 10.9 pKi = 10.9 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 10.1021/jm200221q
7780 7721 0 None 741 2 Human 10.9 pKi = 10.9 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 10.1021/jm200221q
CHEMBL1774519 7721 0 None 741 2 Human 10.9 pKi = 10.9 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 10.1021/jm200221q
53238183 68795 2 None - 1 Human 10.9 pKi = 10.9 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 321 3 1 2 2.8 CC(=O)NCCC1=C(Br)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774521 68795 2 None - 1 Human 10.9 pKi = 10.9 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 321 3 1 2 2.8 CC(=O)NCCC1=C(Br)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
1358 6912 41 None 870 2 Human 10.8 pKi = 10.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm048956y
3976006 6912 41 None 870 2 Human 10.8 pKi = 10.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm048956y
CHEMBL285718 6912 41 None 870 2 Human 10.8 pKi = 10.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm048956y
53237946 68788 0 None 1 2 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 285 4 1 2 3.1 CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774513 68788 0 None 1 2 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 285 4 1 2 3.1 CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
9839629 106892 0 None -1 2 Human 10.7 pKi = 10.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 309 5 1 3 3.8 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL287560 106892 0 None -1 2 Human 10.7 pKi = 10.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 309 5 1 3 3.8 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
10925712 119357 0 None -1 2 Human 10.7 pKi = 10.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 335 7 1 3 4.3 C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL330137 119357 0 None -1 2 Human 10.7 pKi = 10.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 335 7 1 3 4.3 C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
9839629 106892 0 None -1 2 Human 10.7 pKi = 10.7 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins
ChEMBL 309 5 1 3 3.8 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.5b00982
CHEMBL287560 106892 0 None -1 2 Human 10.7 pKi = 10.7 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins
ChEMBL 309 5 1 3 3.8 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.5b00982
53238186 68798 0 None 54 2 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 349 5 1 3 3.6 COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1 10.1021/jm200221q
CHEMBL1774525 68798 0 None 54 2 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 349 5 1 3 3.6 COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1 10.1021/jm200221q
22004791 68787 0 None 2 2 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 243 3 1 2 2.1 CC(=O)NCCC1=CCc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774512 68787 0 None 2 2 Human 10.7 pKi = 10.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 243 3 1 2 2.1 CC(=O)NCCC1=CCc2ccc3c(c21)CCO3 10.1021/jm200221q
24750077 155823 0 None 691 2 Human 10.6 pKi = 10.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 314 7 1 4 3.0 COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1 10.1021/jm700957j
CHEMBL394273 155823 0 None 691 2 Human 10.6 pKi = 10.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 314 7 1 4 3.0 COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1 10.1021/jm700957j
137642160 165171 0 None 165 2 Human 10.5 pKi = 10.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 308 5 1 5 1.3 COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4089965 165171 0 None 165 2 Human 10.5 pKi = 10.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 308 5 1 5 1.3 COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 10.1016/j.ejmech.2016.12.013
127042442 144689 0 None 6 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 328 5 1 4 3.3 COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3763503 144689 0 None 6 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 328 5 1 4 3.3 COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
71533430 93189 0 None 1 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 241 3 1 2 3.0 COc1ccc2cccc(/C=C/NC(C)=O)c2c1 10.1016/j.bmcl.2012.11.069
CHEMBL2314255 93189 0 None 1 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 241 3 1 2 3.0 COc1ccc2cccc(/C=C/NC(C)=O)c2c1 10.1016/j.bmcl.2012.11.069
46884551 14957 0 None - 1 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 373 10 1 5 3.4 COc1cc(COc2ccc(OC)cc2CCCNC(C)=O)cc(OC)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1091998 14957 0 None - 1 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 373 10 1 5 3.4 COc1cc(COc2ccc(OC)cc2CCCNC(C)=O)cc(OC)c1 10.1016/j.bmcl.2010.02.084
18466111 26617 0 None -1 2 Human 10.5 pKi = 10.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL130214 26617 0 None -1 2 Human 10.5 pKi = 10.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
53238185 68797 0 None 2 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 320 4 1 3 3.0 CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774524 68797 0 None 2 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 320 4 1 3 3.0 CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
53237948 68790 0 None 3 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 311 5 1 2 3.5 CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1 10.1021/jm200221q
CHEMBL1774515 68790 0 None 3 2 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 311 5 1 2 3.5 CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1 10.1021/jm200221q
53238408 68800 0 None 81 2 Human 10.4 pKi = 10.4 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 349 5 1 3 3.6 COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1 10.1021/jm200221q
CHEMBL1774527 68800 0 None 81 2 Human 10.4 pKi = 10.4 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 349 5 1 3 3.6 COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1 10.1021/jm200221q
1351 9174 21 None 1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)
ChEMBL 280 4 2 2 3.1 COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C 10.1039/C4MD00149D
219018 9174 21 None 1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)
ChEMBL 280 4 2 2 3.1 COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C 10.1039/C4MD00149D
CHEMBL4079759 9174 21 None 1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)
ChEMBL 280 4 2 2 3.1 COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C 10.1039/C4MD00149D
9873402 42613 0 None -1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 596 19 2 4 7.9 CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
CHEMBL14417 42613 0 None -1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 596 19 2 4 7.9 CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
10925379 214344 0 None -1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 324 5 2 3 3.6 CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL94838 214344 0 None -1 2 Human 10.4 pKi = 10.4 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 324 5 2 3 3.6 CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
44272335 75451 0 None 23 2 Human 10.4 pKi = 10.4 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 7 2 3 3.6 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2 10.1016/j.bmcl.2003.12.052
CHEMBL19211 75451 0 None 23 2 Human 10.4 pKi = 10.4 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 7 2 3 3.6 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2 10.1016/j.bmcl.2003.12.052
1356 10061 99 None -3 2 Human 10.4 pKi = 10.4 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/jm0201159
208902 10061 99 None -3 2 Human 10.4 pKi = 10.4 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/jm0201159
2355 10061 99 None -3 2 Human 10.4 pKi = 10.4 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/jm0201159
CHEMBL1218 10061 99 None -3 2 Human 10.4 pKi = 10.4 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/jm0201159
DB00980 10061 99 None -3 2 Human 10.4 pKi = 10.4 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/jm0201159
11100761 108568 4 None 1 2 Human 10.3 pKi = 10.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 372 4 1 3 2.5 COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C 10.1021/jm011053+
CHEMBL300056 108568 4 None 1 2 Human 10.3 pKi = 10.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 372 4 1 3 2.5 COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C 10.1021/jm011053+
46885226 14844 0 None 18620 2 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 313 8 1 3 3.3 COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1091160 14844 0 None 18620 2 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 313 8 1 3 3.3 COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
9927219 119099 0 None 25 2 Human 10.3 pKi = 10.3 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 323 6 1 3 3.7 COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL329263 119099 0 None 25 2 Human 10.3 pKi = 10.3 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 323 6 1 3 3.7 COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
1350 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10.1021/jm980684+
4172142 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10.1021/jm980684+
CHEMBL10009 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10.1021/jm980684+
9927219 119099 0 None 25 2 Human 10.3 pKi = 10.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins
ChEMBL 323 6 1 3 3.7 COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.5b00982
CHEMBL329263 119099 0 None 25 2 Human 10.3 pKi = 10.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins
ChEMBL 323 6 1 3 3.7 COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.5b00982
9927219 119099 0 None 25 2 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 323 6 1 3 3.7 COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm401343c
CHEMBL329263 119099 0 None 25 2 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 323 6 1 3 3.7 COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm401343c
1350 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10.1021/jm401343c
4172142 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10.1021/jm401343c
CHEMBL10009 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10.1021/jm401343c
164621472 192674 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 288 4 1 3 3.6 CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4868554 192674 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 288 4 1 3 3.6 CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21 10.1021/acs.jmedchem.0c01836
10926138 214756 0 None 57 2 Human 10.2 pKi = 10.2 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 349 8 1 3 4.3 C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL97186 214756 0 None 57 2 Human 10.2 pKi = 10.2 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 349 8 1 3 4.3 C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
9858255 214856 0 None 30 2 Human 10.2 pKi = 10.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 320 4 1 3 3.4 COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 10.1021/jm980684+
CHEMBL9772 214856 0 None 30 2 Human 10.2 pKi = 10.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 320 4 1 3 3.4 COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 10.1021/jm980684+
16656789 95326 0 None 63 2 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 284 6 1 3 3.0 COc1cccc(N(CCNC(C)=O)c2ccccc2)c1 10.1021/jm700957j
CHEMBL235327 95326 0 None 63 2 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 284 6 1 3 3.0 COc1cccc(N(CCNC(C)=O)c2ccccc2)c1 10.1021/jm700957j
9839199 28135 0 None 1 2 Human 10.2 pKi = 10.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
CHEMBL131424 28135 0 None 1 2 Human 10.2 pKi = 10.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
9904304 27917 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL131252 27917 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2cccc3ccc(OC)c1c23 10.1021/jm000922c
10452167 85564 0 None -1 2 Human 10.2 pKi = 10.2 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 376 9 1 3 5.0 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2003.12.052
CHEMBL2112690 85564 0 None -1 2 Human 10.2 pKi = 10.2 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 376 9 1 3 5.0 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2003.12.052
145982333 173336 0 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4279639 173336 0 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
57781216 132625 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648356 132625 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
71533431 6866 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 271 4 1 3 3.0 COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC 10.1016/j.bmcl.2012.11.069
7775 6866 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 271 4 1 3 3.0 COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC 10.1016/j.bmcl.2012.11.069
CHEMBL2314259 6866 0 None -2 2 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 271 4 1 3 3.0 COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC 10.1016/j.bmcl.2012.11.069
57781227 132623 0 None 6 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 244 3 1 3 2.4 CC(=O)NCCC1CCc2ccc3ncoc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648354 132623 0 None 6 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 244 3 1 3 2.4 CC(=O)NCCC1CCc2ccc3ncoc3c21 10.1021/acs.jmedchem.0c01836
71508232 93848 0 None 524 2 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 351 7 1 3 3.6 CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326200 93848 0 None 524 2 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 351 7 1 3 3.6 CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
44272320 105378 0 None 2 2 Human 10.1 pKi = 10.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 288 6 2 3 3.2 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL276921 105378 0 None 2 2 Human 10.1 pKi = 10.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 288 6 2 3 3.2 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1 10.1016/j.bmcl.2003.12.052
127042791 144838 0 None 2 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 360 4 1 4 2.1 COc1ccc2oc(I)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3765401 144838 0 None 2 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 360 4 1 4 2.1 COc1ccc2oc(I)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
53237950 68792 0 None 13 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 314 5 2 2 3.3 CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774517 68792 0 None 13 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 314 5 2 2 3.3 CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
10659603 27028 0 None 1 2 Human 10.1 pKi = 10.1 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 4 1 2 3.0 CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL130542 27028 0 None 1 2 Human 10.1 pKi = 10.1 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 4 1 2 3.0 CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
24955343 70566 0 None -1 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 321 4 1 4 2.6 CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802022 70566 0 None -1 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 321 4 1 4 2.6 CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3 10.1021/jm200385u
23725567 132631 0 None -2 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 274 3 1 3 3.2 CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648362 132631 0 None -2 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 274 3 1 3 3.2 CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 10.1021/acs.jmedchem.0c01836
23725514 132627 0 None -1 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 272 4 1 3 3.1 CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648358 132627 0 None -1 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 272 4 1 3 3.1 CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
127026423 144597 0 None 31 3 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 283 4 1 3 3.3 COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759802 144597 0 None 31 3 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 283 4 1 3 3.3 COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
137636213 162865 0 None 8 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 273 5 2 3 2.1 CCNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4062947 162865 0 None 8 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 273 5 2 3 2.1 CCNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
137647756 164723 0 None 6 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 259 4 2 3 1.7 CNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4084612 164723 0 None 6 2 Human 10.1 pKi = 10.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 259 4 2 3 1.7 CNC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
127040021 144797 0 None 24 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 360 5 1 4 4.3 COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3764765 144797 0 None 24 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 360 5 1 4 4.3 COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
71540389 93190 0 None 1 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 241 3 1 2 3.0 COc1ccc2ccccc2c1/C=C/NC(C)=O 10.1016/j.bmcl.2012.11.069
CHEMBL2314257 93190 0 None 1 2 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 241 3 1 2 3.0 COc1ccc2ccccc2c1/C=C/NC(C)=O 10.1016/j.bmcl.2012.11.069
10515048 123589 0 None 8 2 Human 10.0 pKi = 10.0 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 253 4 1 1 3.4 CCCC(=O)NCC1Cc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL337882 123589 0 None 8 2 Human 10.0 pKi = 10.0 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 253 4 1 1 3.4 CCCC(=O)NCC1Cc2cccc3cccc1c23 10.1021/jm000922c
9903515 29565 0 None -9 2 Human 10.0 pKi = 10.0 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 3 1 2 3.0 COc1ccc2cccc3c2c1C(CNC(C)=O)CC3 10.1021/jm000922c
CHEMBL132802 29565 0 None -9 2 Human 10.0 pKi = 10.0 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 3 1 2 3.0 COc1ccc2cccc3c2c1C(CNC(C)=O)CC3 10.1021/jm000922c
9797460 124931 0 None -6 2 Human 10.0 pKi = 10 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 327 6 1 3 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL340832 124931 0 None -6 2 Human 10.0 pKi = 10 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 327 6 1 3 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
44264769 103772 0 None 10 2 Human 10.0 pKi = 10 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 298 6 1 3 4.2 CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL266549 103772 0 None 10 2 Human 10.0 pKi = 10 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 298 6 1 3 4.2 CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
145982070 173254 0 None -1 2 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 283 3 1 2 3.2 COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4278248 173254 0 None -1 2 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 283 3 1 2 3.2 COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
145981162 173276 0 None 3 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 270 3 2 2 2.5 COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4278575 173276 0 None 3 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 270 3 2 2 2.5 COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 10.1016/j.ejmech.2017.10.025
145982167 173390 0 None 7 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 305 4 1 3 2.4 COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4280601 173390 0 None 7 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 305 4 1 3 2.4 COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 10.1016/j.ejmech.2017.10.025
145979282 173454 0 None 16 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4281915 173454 0 None 16 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145987794 173899 0 None 19 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 298 4 2 2 3.2 CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4290302 173899 0 None 19 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 298 4 2 2 3.2 CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145988741 174015 0 None 6 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 299 5 1 3 2.6 COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4292336 174015 0 None 6 3 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 299 5 1 3 2.6 COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
137655238 165664 0 None 19 2 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 275 4 2 3 1.9 CNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4095210 165664 0 None 19 2 Human 10.0 pKi = 10 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 275 4 2 3 1.9 CNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
198 7101 126 None 1 6 Human 10.0 pKi = 10 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmcl.2012.11.069
82148 7101 126 None 1 6 Human 10.0 pKi = 10 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmcl.2012.11.069
99 7101 126 None 1 6 Human 10.0 pKi = 10 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmcl.2012.11.069
CHEMBL10878 7101 126 None 1 6 Human 10.0 pKi = 10 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmcl.2012.11.069
DB06594 7101 126 None 1 6 Human 10.0 pKi = 10 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmcl.2012.11.069
24750071 105696 0 None 39 2 Human 10.0 pKi = 10.0 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 312 8 1 3 3.8 CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1 10.1021/jm700957j
CHEMBL279401 105696 0 None 39 2 Human 10.0 pKi = 10.0 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 312 8 1 3 3.8 CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1 10.1021/jm700957j
9839199 28135 0 None 1 2 Human 10.0 pKi = 10.0 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
CHEMBL131424 28135 0 None 1 2 Human 10.0 pKi = 10.0 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
10385056 119013 0 None 194 2 Human 10.0 pKi = 10.0 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 379 9 1 4 4.3 C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL329086 119013 0 None 194 2 Human 10.0 pKi = 10.0 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 379 9 1 4 4.3 C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm0005252
44581851 181990 0 None 1202 2 Human 10.0 pKi = 10.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 333 6 1 2 4.5 COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1 10.1021/jm800974d
CHEMBL457128 181990 0 None 1202 2 Human 10.0 pKi = 10.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 333 6 1 2 4.5 COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1 10.1021/jm800974d
10385056 119013 0 None 194 2 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 379 9 1 4 4.3 C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm401343c
CHEMBL329086 119013 0 None 194 2 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 379 9 1 4 4.3 C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm401343c
1356 10061 99 None -3 2 Human 10.0 pKi = 10.0 Binding
Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/acs.jmedchem.0c01836
208902 10061 99 None -3 2 Human 10.0 pKi = 10.0 Binding
Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/acs.jmedchem.0c01836
2355 10061 99 None -3 2 Human 10.0 pKi = 10.0 Binding
Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/acs.jmedchem.0c01836
CHEMBL1218 10061 99 None -3 2 Human 10.0 pKi = 10.0 Binding
Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/acs.jmedchem.0c01836
DB00980 10061 99 None -3 2 Human 10.0 pKi = 10.0 Binding
Binding affinity to human MT2 expressed in CHO cellsBinding affinity to human MT2 expressed in CHO cells
ChEMBL 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 10.1021/acs.jmedchem.0c01836
24750189 96255 0 None 1174 2 Human 10.0 pKi = 10.0 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 334 6 1 3 4.1 COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1 10.1021/jm700957j
CHEMBL237234 96255 0 None 1174 2 Human 10.0 pKi = 10.0 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 334 6 1 3 4.1 COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1 10.1021/jm700957j
10562968 26967 0 None -1 2 Human 9.9 pKi = 9.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 255 3 1 2 2.6 COc1ccc2cccc3c2c1C(CNC(C)=O)C3 10.1021/jm000922c
CHEMBL130490 26967 0 None -1 2 Human 9.9 pKi = 9.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 255 3 1 2 2.6 COc1ccc2cccc3c2c1C(CNC(C)=O)C3 10.1021/jm000922c
44264818 212004 0 None 91 2 Human 9.9 pKi = 9.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 283 6 1 2 4.0 CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7867 212004 0 None 91 2 Human 9.9 pKi = 9.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 283 6 1 2 4.0 CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
10712733 215221 0 None 48 2 Human 9.9 pKi = 9.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 5 1 3 3.9 CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 10.1021/jm980684+
CHEMBL9997 215221 0 None 48 2 Human 9.9 pKi = 9.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 5 1 3 3.9 CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 10.1021/jm980684+
1357 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
1672 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
224 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
896 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
CHEMBL45 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
DB01065 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c00627
57781240 192767 0 None 36 2 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 334 5 1 3 4.0 CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4870108 192767 0 None 36 2 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 334 5 1 3 4.0 CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21 10.1021/acs.jmedchem.0c01836
1357 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm970437q
1672 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm970437q
224 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm970437q
896 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm970437q
CHEMBL45 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm970437q
DB01065 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm970437q
9817262 26256 0 None 1 2 Human 9.9 pKi = 9.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 4 1 2 3.4 CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
CHEMBL129889 26256 0 None 1 2 Human 9.9 pKi = 9.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 4 1 2 3.4 CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
44272410 74791 0 None 7 2 Human 9.9 pKi = 9.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 274 5 2 3 2.9 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL19128 74791 0 None 7 2 Human 9.9 pKi = 9.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 274 5 2 3 2.9 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 10.1016/j.bmcl.2003.12.052
23725565 132624 0 None -1 2 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648355 132624 0 None -1 2 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
1357 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2020.112090
1672 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2020.112090
224 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2020.112090
896 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2020.112090
CHEMBL45 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2020.112090
DB01065 9263 139 None 1 9 Human 9.9 pKi = 9.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2020.112090
44272317 105689 0 None 1 2 Human 9.9 pKi = 9.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 300 6 2 3 3.2 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL279343 105689 0 None 1 2 Human 9.9 pKi = 9.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 300 6 2 3 3.2 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 10.1016/j.bmcl.2003.12.052
53310841 70571 0 None -5 2 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 299 5 1 4 2.2 CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802028 70571 0 None -5 2 Human 9.9 pKi = 9.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 299 5 1 4 2.2 CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 10.1021/jm200385u
127042142 144853 0 None -3 2 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 310 5 1 4 3.2 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3765540 144853 0 None -3 2 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 310 5 1 4 3.2 COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
9926304 123353 0 None -9 2 Human 9.8 pKi = 9.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 299 4 1 3 3.0 COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O 10.1021/jm000922c
CHEMBL336509 123353 0 None -9 2 Human 9.8 pKi = 9.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 299 4 1 3 3.0 COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O 10.1021/jm000922c
115348 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1016/S0960-894X(97)00444-7
1343 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1016/S0960-894X(97)00444-7
CHEMBL289233 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1016/S0960-894X(97)00444-7
DB08190 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cellsCompound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1016/S0960-894X(97)00444-7
1357 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
1672 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
224 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
896 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
CHEMBL45 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
DB01065 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.5b00245
1357 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.09.003
1672 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.09.003
224 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.09.003
896 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.09.003
CHEMBL45 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.09.003
DB01065 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.09.003
57781246 132635 0 None 2 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 284 4 1 3 3.3 CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648366 132635 0 None 2 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 284 4 1 3 3.3 CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 10.1021/acs.jmedchem.0c01836
23725612 132636 0 None 2 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 274 4 1 4 2.4 COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 10.1021/acs.jmedchem.0c01836
CHEMBL3648367 132636 0 None 2 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 274 4 1 4 2.4 COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 10.1021/acs.jmedchem.0c01836
9796846 123214 0 None -12 2 Human 9.8 pKi = 9.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 313 5 1 3 3.4 CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL336054 123214 0 None -12 2 Human 9.8 pKi = 9.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 313 5 1 3 3.4 CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
10522674 214540 0 None 56 2 Human 9.8 pKi = 9.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 7 1 3 4.5 CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2 10.1021/jm980684+
CHEMBL9590 214540 0 None 56 2 Human 9.8 pKi = 9.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 7 1 3 4.5 CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2 10.1021/jm980684+
10244841 74269 1 None 8 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 309 4 1 2 3.5 CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 10.1021/jm800974d
CHEMBL189414 74269 1 None 8 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 309 4 1 2 3.5 CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 10.1021/jm800974d
23725515 132634 0 None 1 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 272 4 1 3 2.9 CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 10.1021/acs.jmedchem.0c01836
CHEMBL3648365 132634 0 None 1 2 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 272 4 1 3 2.9 CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 10.1021/acs.jmedchem.0c01836
115348 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm011053+
1343 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm011053+
CHEMBL289233 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm011053+
DB08190 6858 47 None -4 2 Human 9.8 pKi = 9.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm011053+
10244841 74269 1 None 8 2 Human 9.8 pKi = 9.8 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 309 4 1 2 3.5 CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 10.1021/jm040768k
CHEMBL189414 74269 1 None 8 2 Human 9.8 pKi = 9.8 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 309 4 1 2 3.5 CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 10.1021/jm040768k
44264892 211959 0 None 5 2 Human 9.8 pKi = 9.8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 284 5 1 3 3.8 CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7832 211959 0 None 5 2 Human 9.8 pKi = 9.8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 284 5 1 3 3.8 CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
9840647 104997 0 None 25 2 Human 9.8 pKi = 9.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 334 5 1 3 3.7 CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2 10.1021/jm980684+
CHEMBL274317 104997 0 None 25 2 Human 9.8 pKi = 9.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 334 5 1 3 3.7 CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2 10.1021/jm980684+
11079938 200636 4 None 1 2 Human 9.8 pKi = 9.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 403 5 2 4 2.4 COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL52755 200636 4 None 1 2 Human 9.8 pKi = 9.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 403 5 2 4 2.4 COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-] 10.1021/jm011053+
1357 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
1672 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
224 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
896 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
CHEMBL45 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
DB01065 9263 139 None 1 9 Human 9.8 pKi = 9.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.2c00717
9916005 39486 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 568 17 2 4 7.1 CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
CHEMBL14136 39486 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 568 17 2 4 7.1 CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
44353165 123692 0 None 7 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 267 4 1 1 3.8 CCCC(=O)NCC1CCc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL338425 123692 0 None 7 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 267 4 1 1 3.8 CCCC(=O)NCC1CCc2cccc3cccc1c23 10.1021/jm000922c
1357 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1672 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
224 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
896 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
CHEMBL45 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
DB01065 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1357 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1672 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
224 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
896 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
CHEMBL45 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
DB01065 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
9798080 26257 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 341 7 1 3 4.2 CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL129890 26257 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 341 7 1 3 4.2 CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
15453821 211884 0 None 151 2 Human 9.7 pKi = 9.7 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 301 6 1 3 4.6 CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7771 211884 0 None 151 2 Human 9.7 pKi = 9.7 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 301 6 1 3 4.6 CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
10016733 85574 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 284 5 1 3 3.0 CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2003.12.052
CHEMBL2112724 85574 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 284 5 1 3 3.0 CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2003.12.052
56653119 178571 0 None -1 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 322 7 2 2 3.5 CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12 10.1016/j.ejmech.2019.111847
CHEMBL4467954 178571 0 None -1 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 322 7 2 2 3.5 CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12 10.1016/j.ejmech.2019.111847
53310839 70568 0 None -2 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 273 4 1 4 1.6 CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802024 70568 0 None -2 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 273 4 1 4 1.6 CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 10.1021/jm200385u
1357 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0201159
1672 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0201159
224 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0201159
896 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0201159
CHEMBL45 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0201159
DB01065 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Binding affinity against human Melatonin receptor type 1B (MT2)Binding affinity against human Melatonin receptor type 1B (MT2)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0201159
24750191 95327 0 None 85 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 332 5 1 2 3.7 CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1 10.1021/jm700957j
CHEMBL235328 95327 0 None 85 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 332 5 1 2 3.7 CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1 10.1021/jm700957j
11810280 214710 0 None 16 2 Human 9.7 pKi = 9.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 351 8 1 3 4.5 CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL96859 214710 0 None 16 2 Human 9.7 pKi = 9.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 351 8 1 3 4.5 CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
1346 6948 47 None 25 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 10.1016/j.ejmech.2019.111847
1858 6948 47 None 25 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 10.1016/j.ejmech.2019.111847
CHEMBL34730 6948 47 None 25 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 10.1016/j.ejmech.2019.111847
10522675 11110 0 None 20 2 Human 9.7 pKi = 9.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 6 1 3 4.3 CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 10.1021/jm980684+
CHEMBL10099 11110 0 None 20 2 Human 9.7 pKi = 9.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 6 1 3 4.3 CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 10.1021/jm980684+
10522675 11110 0 None 20 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 362 6 1 3 4.3 CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 10.1016/j.ejmech.2019.111847
CHEMBL10099 11110 0 None 20 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 362 6 1 3 4.3 CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 10.1016/j.ejmech.2019.111847
198 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
82148 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
99 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
CHEMBL10878 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
DB06594 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2017.10.025
145982333 173336 0 None -1 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4279639 173336 0 None -1 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145979689 173402 0 None 5 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 314 3 2 2 3.1 CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4280791 173402 0 None 5 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 314 3 2 2 3.1 CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145981769 173446 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 270 3 1 3 2.4 COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4281712 173446 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 270 3 1 3 2.4 COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
145993214 173530 0 None 5 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 285 3 2 3 2.2 CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4283539 173530 0 None 5 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 285 3 2 3 2.2 CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 10.1016/j.ejmech.2017.10.025
145993188 173801 0 None 3 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 319 4 1 3 2.6 COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4288497 173801 0 None 3 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 319 4 1 3 2.6 COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3 10.1016/j.ejmech.2017.10.025
145988269 173969 0 None 10 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 326 5 2 2 3.8 CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4291381 173969 0 None 10 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 326 5 2 2 3.8 CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145986532 174060 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 269 3 1 2 3.0 COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4293386 174060 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 269 3 1 2 3.0 COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
145993566 174150 0 None 25 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 312 5 2 2 3.6 CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4294790 174150 0 None 25 3 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 312 5 2 2 3.6 CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
198 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
82148 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
99 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
CHEMBL10878 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
DB06594 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2016.12.013
137639112 163631 0 None 10 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 245 4 2 3 1.5 COc1ccc2cccc(CCNC(N)=O)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4071572 163631 0 None 10 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 245 4 2 3 1.5 COc1ccc2cccc(CCNC(N)=O)c2n1 10.1016/j.ejmech.2016.12.013
137660333 166299 0 None 1 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 COc1ccc2cccc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4102177 166299 0 None 1 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 COc1ccc2cccc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.12.013
56659223 71763 0 None -5 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 309 5 2 3 2.9 COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2011.06.030
CHEMBL1823015 71763 0 None -5 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 309 5 2 3 2.9 COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2011.06.030
1346 6948 47 None 25 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 10.1021/jm401343c
1858 6948 47 None 25 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 10.1021/jm401343c
CHEMBL34730 6948 47 None 25 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 10.1021/jm401343c
15453090 93187 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 285 4 1 3 2.8 COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1 10.1016/j.bmcl.2012.11.069
CHEMBL2314253 93187 0 None -3 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 285 4 1 3 2.8 COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1 10.1016/j.bmcl.2012.11.069
11110447 214568 0 None 4 2 Human 9.7 pKi = 9.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 335 6 1 3 4.3 C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL96104 214568 0 None 4 2 Human 9.7 pKi = 9.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 335 6 1 3 4.3 C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
10854190 105089 0 None 87 2 Human 9.7 pKi = 9.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 334 5 1 3 3.7 CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 10.1021/jm980684+
CHEMBL274896 105089 0 None 87 2 Human 9.7 pKi = 9.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 334 5 1 3 3.7 CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 10.1021/jm980684+
198 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
82148 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
99 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
CHEMBL10878 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
DB06594 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2015.12.047
1357 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
1672 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
224 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
896 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
CHEMBL45 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
DB01065 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200385u
1357 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
1672 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
224 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
896 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
CHEMBL45 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
DB01065 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.0c01836
198 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
82148 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
99 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
CHEMBL10878 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
DB06594 7101 126 None 1 6 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.ejmech.2020.112078
1357 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
1672 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
224 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
896 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
CHEMBL45 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
DB01065 9263 139 None 1 9 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm200221q
16094584 90020 0 None 33 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 281 5 1 2 3.3 COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 10.1021/jm060850a
CHEMBL218708 90020 0 None 33 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 281 5 1 2 3.3 COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 10.1021/jm060850a
10752506 26758 0 None 5 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 239 2 1 1 3.0 CC(=O)NCC1CCc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL130319 26758 0 None 5 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 239 2 1 1 3.0 CC(=O)NCC1CCc2cccc3cccc1c23 10.1021/jm000922c
10561982 29794 0 None 12 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 239 3 1 1 3.0 CCC(=O)NCC1Cc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL133001 29794 0 None 12 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 239 3 1 1 3.0 CCC(=O)NCC1Cc2cccc3cccc1c23 10.1021/jm000922c
11002840 214306 0 None 33 2 Human 9.7 pKi = 9.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 357 6 1 3 4.4 COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL94607 214306 0 None 33 2 Human 9.7 pKi = 9.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 357 6 1 3 4.4 COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
137648419 164618 0 None 15 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 293 4 1 1 3.9 CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1 10.1021/acs.jmedchem.8b00359
CHEMBL4083618 164618 0 None 15 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 293 4 1 1 3.9 CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1 10.1021/acs.jmedchem.8b00359
24954990 70569 0 None -5 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 287 5 1 4 1.9 CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802026 70569 0 None -5 2 Human 9.7 pKi = 9.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 287 5 1 4 1.9 CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3 10.1021/jm200385u
115348 6858 47 None -4 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm401343c
1343 6858 47 None -4 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm401343c
CHEMBL289233 6858 47 None -4 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm401343c
DB08190 6858 47 None -4 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 10.1021/jm401343c
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00392-2
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00392-2
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00392-2
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00392-2
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00392-2
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00392-2
9884406 214405 0 None 3 2 Human 9.6 pKi = 9.6 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 341 6 1 3 3.9 COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL95166 214405 0 None 3 2 Human 9.6 pKi = 9.6 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 341 6 1 3 3.9 COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
44264903 212397 0 None -4 2 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 270 4 1 3 3.4 COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL8168 212397 0 None -4 2 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 270 4 1 3 3.4 COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1 10.1016/j.bmcl.2003.11.030
137637541 162777 0 None 269 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 293 4 1 1 3.9 CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1 10.1021/acs.jmedchem.8b00359
CHEMBL4061850 162777 0 None 269 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 293 4 1 1 3.9 CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1 10.1021/acs.jmedchem.8b00359
57781208 192400 0 None 5 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 320 4 1 3 4.1 CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4864102 192400 0 None 5 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 320 4 1 3 4.1 CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21 10.1021/acs.jmedchem.0c01836
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm700957j
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm700957j
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm700957j
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm700957j
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm700957j
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm700957j
10540964 123406 0 None -1 2 Human 9.6 pKi = 9.6 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL336858 123406 0 None -1 2 Human 9.6 pKi = 9.6 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
44272316 74374 0 None -4 2 Human 9.6 pKi = 9.6 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 392 10 2 3 5.3 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 10.1016/j.bmcl.2003.12.052
CHEMBL19026 74374 0 None -4 2 Human 9.6 pKi = 9.6 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 392 10 2 3 5.3 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 10.1016/j.bmcl.2003.12.052
139451781 191637 0 None 1 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 289 5 1 5 1.5 CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
CHEMBL4852440 191637 0 None 1 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 289 5 1 5 1.5 CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
52953165 69182 0 None 218 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 7 1 3 5.6 C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779810 69182 0 None 218 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 7 1 3 5.6 C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
10019103 74267 0 None 5 2 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 323 5 1 2 3.8 CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 10.1021/jm040768k
CHEMBL189395 74267 0 None 5 2 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 323 5 1 2 3.8 CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 10.1021/jm040768k
129776 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 10.1016/j.ejmech.2019.111847
1364 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 10.1016/j.ejmech.2019.111847
CHEMBL339105 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method
ChEMBL 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 10.1016/j.ejmech.2019.111847
1353 10208 5 None 112 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm800974d
9998187 10208 5 None 112 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm800974d
CHEMBL33549 10208 5 None 112 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm800974d
129776 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 10.1021/jm401343c
1364 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 10.1021/jm401343c
CHEMBL339105 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 10.1021/jm401343c
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm060850a
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm060850a
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm060850a
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm060850a
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm060850a
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm060850a
9840277 30335 0 None -10 2 Human 9.6 pKi = 9.6 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 325 5 1 3 3.4 COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1 10.1021/jm000922c
CHEMBL133416 30335 0 None -10 2 Human 9.6 pKi = 9.6 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 325 5 1 3 3.4 COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1 10.1021/jm000922c
10617720 214598 0 None 56 2 Human 9.6 pKi = 9.6 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 6 1 3 4.1 CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1 10.1021/jm980684+
CHEMBL9630 214598 0 None 56 2 Human 9.6 pKi = 9.6 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 6 1 3 4.1 CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1 10.1021/jm980684+
198 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
82148 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
99 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
CHEMBL10878 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
DB06594 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm0255872
198 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
82148 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
99 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
CHEMBL10878 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
DB06594 7101 126 None 1 6 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1016/j.bmc.2008.08.052
1354 10209 15 None 275 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 10.1016/j.bmc.2008.08.052
22133318 10209 15 None 275 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 10.1016/j.bmc.2008.08.052
CHEMBL490188 10209 15 None 275 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 10.1016/j.bmc.2008.08.052
11644612 85073 0 None 9 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.4 COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C 10.1021/jm0512544
CHEMBL210791 85073 0 None 9 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.4 COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C 10.1021/jm0512544
16094586 89923 4 None 213 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 311 6 1 3 3.3 COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1 10.1021/jm060850a
CHEMBL218225 89923 4 None 213 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 311 6 1 3 3.3 COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1 10.1021/jm060850a
44272334 74409 0 None 17 2 Human 9.6 pKi = 9.6 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 6 2 3 3.5 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL19050 74409 0 None 17 2 Human 9.6 pKi = 9.6 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 6 2 3 3.5 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 10.1016/j.bmcl.2003.12.052
139451763 193112 0 None 1 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 305 8 1 5 2.4 CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 10.1021/acs.jmedchem.0c00627
CHEMBL4874954 193112 0 None 1 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 305 8 1 5 2.4 CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 10.1021/acs.jmedchem.0c00627
52918078 67528 0 None 11 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 247 5 1 4 1.6 CCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
CHEMBL1760946 67528 0 None 11 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 247 5 1 4 1.6 CCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
53310840 70570 0 None -6 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 285 4 1 4 1.8 CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802027 70570 0 None -6 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 285 4 1 4 1.8 CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 10.1021/jm200385u
12985495 188165 0 None 213 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 8 2 3 4.5 CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
CHEMBL476341 188165 0 None 213 2 Human 9.6 pKi = 9.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 8 2 3 4.5 CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm040768k
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm040768k
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm040768k
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm040768k
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm040768k
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm040768k
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm001125h
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm001125h
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm001125h
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm001125h
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm001125h
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm001125h
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm048956y
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm048956y
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm048956y
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm048956y
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm048956y
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm048956y
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.8b00893
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.8b00893
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.8b00893
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.8b00893
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.8b00893
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/acs.jmedchem.8b00893
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00444-7
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00444-7
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00444-7
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00444-7
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00444-7
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/S0960-894X(97)00444-7
46865422 93846 0 None 575 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326199 93846 0 None 575 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm020982d
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm020982d
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm020982d
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm020982d
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm020982d
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm020982d
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.09.030
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.09.030
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.09.030
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.09.030
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.09.030
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.09.030
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.04.082
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.04.082
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.04.082
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.04.082
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.04.082
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.04.082
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.12.052
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.12.052
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.12.052
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.12.052
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.12.052
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.12.052
137641357 163858 0 None 3 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.1 CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4074273 163858 0 None 3 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.1 CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
21581654 67526 1 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760944 67526 1 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
52918079 67529 0 None 4 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 261 6 1 4 2.0 CCCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
CHEMBL1760947 67529 0 None 4 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 261 6 1 4 2.0 CCCC(=O)NCCn1ccc2ccc(OC)nc21 10.1016/j.bmcl.2011.02.097
145979282 173454 0 None 16 3 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4281915 173454 0 None 16 3 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145992795 173570 0 None 29 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 342 5 2 2 3.9 CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4284223 173570 0 None 29 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 342 5 2 2 3.9 CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145990662 173708 0 None 2 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 312 4 2 2 3.4 CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4286896 173708 0 None 2 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 312 4 2 2 3.4 CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
137636173 162780 0 None 63 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 276 6 1 3 2.3 COc1ccc2cccc(CCC(=O)NCCF)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4061905 162780 0 None 63 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 276 6 1 3 2.3 COc1ccc2cccc(CCC(=O)NCCF)c2n1 10.1016/j.ejmech.2016.12.013
137650611 164291 0 None 26 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 CNC(=O)CCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4079784 164291 0 None 26 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 CNC(=O)CCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
137645530 164502 0 None 23 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 260 4 1 4 2.1 COC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4082097 164502 0 None 23 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 260 4 1 4 2.1 COC(=O)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.03.080
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.03.080
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.03.080
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.03.080
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.03.080
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.03.080
71540396 93192 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 286 4 2 3 2.8 CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12 10.1016/j.bmcl.2012.11.069
CHEMBL2314260 93192 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 286 4 2 3 2.8 CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12 10.1016/j.bmcl.2012.11.069
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
44358146 33850 0 None -2 2 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 4 1 3 2.1 CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL136531 33850 0 None -2 2 Human 9.5 pKi = 9.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 4 1 3 2.1 CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
10850411 122135 0 None 4 2 Human 9.5 pKi = 9.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 281 4 1 2 3.0 COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3 10.1021/jm000922c
CHEMBL334962 122135 0 None 4 2 Human 9.5 pKi = 9.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 281 4 1 2 3.0 COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3 10.1021/jm000922c
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0005252
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.12.013
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.12.013
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.12.013
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.12.013
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.12.013
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.12.013
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm011053+
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm011053+
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm011053+
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm011053+
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm011053+
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm011053+
23658146 163897 1 None 10 3 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
CHEMBL4074895 163897 1 None 10 3 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
1353 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm0005252
9998187 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm0005252
CHEMBL33549 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm0005252
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.11.030
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.11.030
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.11.030
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.11.030
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.11.030
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2003.11.030
44272430 173711 0 None 15 2 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 288 5 2 3 3.1 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
CHEMBL428692 173711 0 None 15 2 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 288 5 2 3 3.1 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
1353 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm048956y
9998187 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm048956y
CHEMBL33549 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm048956y
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm980684+
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm980684+
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm980684+
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm980684+
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm980684+
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm980684+
10446712 85573 0 None -6 2 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 286 6 1 3 3.4 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 10.1016/j.bmcl.2003.12.052
CHEMBL2112722 85573 0 None -6 2 Human 9.5 pKi = 9.5 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 286 6 1 3 3.4 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 10.1016/j.bmcl.2003.12.052
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
53310987 70573 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 327 4 1 4 2.4 CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802030 70573 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 327 4 1 4 2.4 CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 10.1021/jm200385u
1353 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm401343c
9998187 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm401343c
CHEMBL33549 10208 5 None 112 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cells
ChEMBL 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 10.1021/jm401343c
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2011.06.063
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2011.06.063
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2011.06.063
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2011.06.063
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2011.06.063
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2011.06.063
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.04.013
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.04.013
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.04.013
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.04.013
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.04.013
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2007.04.013
71508235 93850 0 None 95 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 327 8 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326203 93850 0 None 95 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 327 8 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 10.1016/j.bmc.2012.10.060
10661735 175103 0 None 1 2 Human 9.5 pKi = 9.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 6 1 2 3.8 CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL434226 175103 0 None 1 2 Human 9.5 pKi = 9.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 6 1 2 3.8 CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
10059864 116600 5 None -2 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL323332 116600 5 None -2 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1021/jm0005252
11824364 119329 0 None 42 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL329960 119329 0 None 42 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 10.1021/jm0005252
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2011.02.097
10059864 116600 5 None -2 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL323332 116600 5 None -2 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1016/j.ejmech.2015.12.047
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.06.030
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.06.030
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.06.030
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.06.030
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.06.030
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.06.030
53238409 68801 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 377 6 1 3 4.4 CC(=O)NCCC1=C(c2ccccc2OC(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774528 68801 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 377 6 1 3 4.4 CC(=O)NCCC1=C(c2ccccc2OC(C)C)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.01.008
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.01.008
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.01.008
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.01.008
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.01.008
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2016.01.008
10059864 116600 5 None -2 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1016/j.ejmech.2016.01.008
CHEMBL323332 116600 5 None -2 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 1 3 2.1 COc1ccc2occ(CCNC(C)=O)c2c1 10.1016/j.ejmech.2016.01.008
122220128 166454 0 None 5 3 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 309 6 2 3 2.3 COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 10.1039/C4MD00149D
CHEMBL4104020 166454 0 None 5 3 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 309 6 2 3 2.3 COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 10.1039/C4MD00149D
18466111 26617 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL130214 26617 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
10882307 214253 0 None 15 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 338 6 2 3 3.5 CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL94301 214253 0 None 15 2 Human 9.5 pKi = 9.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 338 6 2 3 3.5 CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.044
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.044
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.044
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.044
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.044
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2011.02.044
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0512544
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0512544
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0512544
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0512544
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0512544
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0512544
25024912 192698 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 271 4 1 3 2.5 CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4869029 192698 0 None -1 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 271 4 1 3 2.5 CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21 10.1021/acs.jmedchem.0c01836
16750569 94137 0 None 14 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 338 6 2 2 3.4 CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL233308 94137 0 None 14 2 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 338 6 2 2 3.4 CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
1357 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2007.01.005
1672 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2007.01.005
224 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2007.01.005
896 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2007.01.005
CHEMBL45 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2007.01.005
DB01065 9263 139 None 1 9 Human 9.5 pKi = 9.5 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2007.01.005
7922 8737 0 None 741 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 10.1016/j.bmc.2008.08.052
9798456 8737 0 None 741 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 10.1016/j.bmc.2008.08.052
CHEMBL476131 8737 0 None 741 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 10.1016/j.bmc.2008.08.052
21581654 67526 1 None -1 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2011.06.030
CHEMBL1760944 67526 1 None -1 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2011.06.030
21581654 67526 1 None -1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL1760944 67526 1 None -1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 2 3 1.3 COc1ccc2[nH]cc(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
9998754 85569 0 None -7 2 Human 9.4 pKi = 9.4 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 362 8 1 3 4.6 CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2003.12.052
CHEMBL2112700 85569 0 None -7 2 Human 9.4 pKi = 9.4 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 362 8 1 3 4.6 CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2003.12.052
9818487 180312 0 None 141 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 319 5 1 2 4.2 COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL453138 180312 0 None 141 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 319 5 1 2 4.2 COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
139451764 193046 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 275 4 1 5 1.1 COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
CHEMBL4873903 193046 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 275 4 1 5 1.1 COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 10.1021/acs.jmedchem.0c00627
10016919 107386 1 None -3 2 Human 9.4 pKi = 9.4 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 287 6 1 3 2.9 CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL291857 107386 1 None -3 2 Human 9.4 pKi = 9.4 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 287 6 1 3 2.9 CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
10016919 107386 1 None -3 2 Human 9.4 pKi = 9.4 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 287 6 1 3 2.9 CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 10.1021/jm970437q
CHEMBL291857 107386 1 None -3 2 Human 9.4 pKi = 9.4 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 287 6 1 3 2.9 CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 10.1021/jm970437q
198 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
82148 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
99 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
CHEMBL10878 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
DB06594 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1039/C4MD00149D
9925797 29024 0 None -3 2 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 4 1 2 3.4 COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3 10.1021/jm000922c
CHEMBL132340 29024 0 None -3 2 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 4 1 2 3.4 COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3 10.1021/jm000922c
44264705 211240 1 None 79 2 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 284 6 2 3 4.2 CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7229 211240 1 None 79 2 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 284 6 2 3 4.2 CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
44358196 126064 0 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 260 3 1 3 1.7 CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL343825 126064 0 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 260 3 1 3 1.7 CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
127026062 144467 0 None 5 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758717 144467 0 None 5 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 10.1016/j.ejmech.2015.12.047
145979585 173269 0 None 17 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 313 5 2 3 3.0 CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4278446 173269 0 None 17 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 313 5 2 3 3.0 CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 10.1016/j.ejmech.2017.10.025
145991966 173615 0 None 5 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 285 3 1 3 3.2 COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4285145 173615 0 None 5 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 285 3 1 3 3.2 COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145991111 173691 0 None 17 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 319 5 1 3 2.8 CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4286494 173691 0 None 17 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 319 5 1 3 2.8 CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145986330 173836 0 None 15 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 286 3 2 2 2.7 COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4289115 173836 0 None 15 3 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 286 3 2 2 2.7 COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 10.1016/j.ejmech.2017.10.025
137650826 164284 0 None 10 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 289 5 2 3 2.3 CCNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4079699 164284 0 None 10 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 289 5 2 3 2.3 CCNC(=S)NCCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
10333442 210665 0 None 5 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 272 6 1 3 2.7 CCCC(=O)NCCc1ccnc2ccc(OC)cc12 10.1016/S0960-894X(97)00392-2
CHEMBL68864 210665 0 None 5 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 272 6 1 3 2.7 CCCC(=O)NCCc1ccnc2ccc(OC)cc12 10.1016/S0960-894X(97)00392-2
1357 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
1672 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
224 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
896 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
CHEMBL45 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
DB01065 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm0255872
10199282 123371 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 3 1 2 3.0 COc1ccc2cccc3c2c1CCC3CNC(C)=O 10.1021/jm000922c
CHEMBL336647 123371 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 3 1 2 3.0 COc1ccc2cccc3c2c1CCC3CNC(C)=O 10.1021/jm000922c
11733059 118431 0 None 21 2 Human 9.4 pKi = 9.4 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 449 7 1 3 4.1 COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1 10.1021/jm0005252
CHEMBL328617 118431 0 None 21 2 Human 9.4 pKi = 9.4 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 449 7 1 3 4.1 COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1 10.1021/jm0005252
1357 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
1672 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
224 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
896 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
CHEMBL45 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
DB01065 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.08.052
1357 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2014.09.038
1672 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2014.09.038
224 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2014.09.038
896 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2014.09.038
CHEMBL45 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2014.09.038
DB01065 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2014.09.038
11644612 85073 0 None 9 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.4 COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C 10.1021/jm0512544
CHEMBL210791 85073 0 None 9 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.4 COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C 10.1021/jm0512544
10468642 33891 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 275 3 2 3 1.5 CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL136564 33891 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 275 3 2 3 1.5 CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
24954989 8314 1 None -6 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 10.1021/jm200385u
7774 8314 1 None -6 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 10.1021/jm200385u
CHEMBL1802025 8314 1 None -6 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 10.1021/jm200385u
44579259 193893 0 None 331 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 347 6 1 3 4.0 COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL491604 193893 0 None 331 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 347 6 1 3 4.0 COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
1357 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2012.10.060
1672 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2012.10.060
224 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2012.10.060
896 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2012.10.060
CHEMBL45 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2012.10.060
DB01065 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2012.10.060
1357 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2010.02.084
1672 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2010.02.084
224 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2010.02.084
896 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2010.02.084
CHEMBL45 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2010.02.084
DB01065 9263 139 None 1 9 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2010.02.084
10423378 85575 0 None -8 2 Human 9.4 pKi = 9.4 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 272 5 1 3 3.0 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 10.1016/j.bmcl.2003.12.052
CHEMBL2112727 85575 0 None -8 2 Human 9.4 pKi = 9.4 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 272 5 1 3 3.0 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 10.1016/j.bmcl.2003.12.052
198 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm000922c
82148 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm000922c
99 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm000922c
CHEMBL10878 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm000922c
DB06594 7101 126 None 1 6 Human 9.4 pKi = 9.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 10.1021/jm000922c
86273228 128098 0 None 5 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 258 6 2 2 2.4 C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580910 128098 0 None 5 2 Human 9.4 pKi = 9.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 258 6 2 2 2.4 C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
1358 6912 41 None 870 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm800974d
3976006 6912 41 None 870 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm800974d
CHEMBL285718 6912 41 None 870 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm800974d
11652196 145091 0 None 9 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 288 6 1 3 3.2 CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
CHEMBL377101 145091 0 None 9 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 288 6 1 3 3.2 CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
11741001 85579 0 None -9 2 Human 9.3 pKi = 9.3 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 388 9 1 3 5.0 O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 10.1016/j.bmcl.2003.12.052
CHEMBL2112734 85579 0 None -9 2 Human 9.3 pKi = 9.3 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 388 9 1 3 5.0 O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 10.1016/j.bmcl.2003.12.052
137631636 163387 0 None 7 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 308 4 1 2 3.4 CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1 10.1021/acs.jmedchem.8b00359
CHEMBL4068887 163387 0 None 7 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 308 4 1 2 3.4 CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1 10.1021/acs.jmedchem.8b00359
44264861 211923 0 None 74 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 310 5 1 3 4.1 CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7807 211923 0 None 74 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 310 5 1 3 4.1 CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
11824365 114144 0 None 47 2 Human 9.3 pKi = 9.3 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1 10.1021/jm0005252
CHEMBL317742 114144 0 None 47 2 Human 9.3 pKi = 9.3 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 353 7 1 4 3.7 COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1 10.1021/jm0005252
1359 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm980684+
5311198 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm980684+
CHEMBL274438 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm980684+
1359 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm800974d
5311198 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm800974d
CHEMBL274438 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm800974d
137640407 163522 0 None 67 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 270 5 1 3 2.5 COc1ccc2cccc(CCC(=O)NC3CC3)c2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4070527 163522 0 None 67 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 270 5 1 3 2.5 COc1ccc2cccc(CCC(=O)NC3CC3)c2n1 10.1016/j.ejmech.2016.12.013
11644612 85073 0 None 9 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.4 COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C 10.1021/jm0512544
CHEMBL210791 85073 0 None 9 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.4 COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C 10.1021/jm0512544
1357 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2012.11.069
1672 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2012.11.069
224 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2012.11.069
896 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2012.11.069
CHEMBL45 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2012.11.069
DB01065 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2012.11.069
1359 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm401343c
5311198 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm401343c
CHEMBL274438 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm401343c
1359 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm048956y
5311198 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm048956y
CHEMBL274438 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10.1021/jm048956y
10704399 28279 0 None 8 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 225 2 1 1 2.6 CC(=O)NCC1Cc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL131602 28279 0 None 8 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 225 2 1 1 2.6 CC(=O)NCC1Cc2cccc3cccc1c23 10.1021/jm000922c
10616723 105081 0 None 14 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 334 4 1 3 3.6 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1 10.1021/jm980684+
CHEMBL274842 105081 0 None 14 2 Human 9.3 pKi = 9.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 334 4 1 3 3.6 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1 10.1021/jm980684+
44579115 188614 0 None 162 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 348 6 2 3 4.2 CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
CHEMBL477835 188614 0 None 162 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 348 6 2 3 4.2 CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
1357 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.12.047
1672 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.12.047
224 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.12.047
896 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.12.047
CHEMBL45 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.12.047
DB01065 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2015.12.047
12985494 197408 0 None 239 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 7 2 3 4.1 CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
CHEMBL518113 197408 0 None 239 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 7 2 3 4.1 CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 10.1016/j.bmc.2008.08.052
16094585 89665 0 None 204 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 321 6 1 2 4.0 COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm060850a
CHEMBL218065 89665 0 None 204 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 321 6 1 2 4.0 COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm060850a
1357 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm000922c
1672 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm000922c
224 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm000922c
896 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm000922c
CHEMBL45 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm000922c
DB01065 9263 139 None 1 9 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm000922c
24954991 70567 0 None -3 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 259 3 1 4 1.3 CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802023 70567 0 None -3 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 259 3 1 4 1.3 CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 10.1021/jm200385u
23642307 165674 1 None 8 3 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
CHEMBL4095334 165674 1 None 8 3 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
44429448 94522 0 None 7 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 324 5 2 2 3.0 CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL233729 94522 0 None 7 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 324 5 2 2 3.0 CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
9948714 27476 0 None -2 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 313 5 1 3 3.4 COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O 10.1021/jm000922c
CHEMBL130898 27476 0 None -2 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 313 5 1 3 3.4 COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O 10.1021/jm000922c
9883864 123432 0 None -7 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 327 6 1 3 3.8 CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL337024 123432 0 None -7 2 Human 9.3 pKi = 9.3 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 327 6 1 3 3.8 CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 10.1021/jm000922c
71508233 93849 0 None 40 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 355 10 1 3 3.9 CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
CHEMBL2326201 93849 0 None 40 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 355 10 1 3 3.9 CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 10.1016/j.bmc.2012.10.060
12985491 193759 0 None 91 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 411 6 1 2 5.1 COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL490595 193759 0 None 91 2 Human 9.3 pKi = 9.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 411 6 1 2 5.1 COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
10753255 125269 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 251 3 1 1 3.0 O=C(NCC1Cc2cccc3cccc1c23)C1CC1 10.1021/jm000922c
CHEMBL341439 125269 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 251 3 1 1 3.0 O=C(NCC1Cc2cccc3cccc1c23)C1CC1 10.1021/jm000922c
10778397 26607 0 None -1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 4 1 2 3.0 COc1ccc2cccc3c2c1C(CCNC(C)=O)C3 10.1021/jm000922c
CHEMBL130203 26607 0 None -1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 269 4 1 2 3.0 COc1ccc2cccc3c2c1C(CCNC(C)=O)C3 10.1021/jm000922c
52918077 67527 2 None 2 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 1 4 1.2 COc1ccc2ccn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760945 67527 2 None 2 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 1 4 1.2 COc1ccc2ccn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
127026427 144462 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758679 144462 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
1357 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.06.100
1672 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.06.100
224 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.06.100
896 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.06.100
CHEMBL45 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.06.100
DB01065 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2010.06.100
44579260 193894 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 1 4 4.0 COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
CHEMBL491605 193894 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 1 4 4.0 COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
24750192 10689 13 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 222 5 1 3 1.3 COc1cccc(c1)N(CCNC(=O)C)C 10.1021/jm700957j
7777 10689 13 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 222 5 1 3 1.3 COc1cccc(c1)N(CCNC(=O)C)C 10.1021/jm700957j
CHEMBL237236 10689 13 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 222 5 1 3 1.3 COc1cccc(c1)N(CCNC(=O)C)C 10.1021/jm700957j
11185529 10686 5 None 14 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm040768k
7772 10686 5 None 14 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm040768k
CHEMBL189449 10686 5 None 14 2 Human 9.2 pKi = 9.2 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm040768k
11185529 10686 5 None 14 2 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm048956y
7772 10686 5 None 14 2 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm048956y
CHEMBL189449 10686 5 None 14 2 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 10.1021/jm048956y
44429447 94521 0 None 5 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 310 4 2 2 2.6 COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.04.013
CHEMBL233728 94521 0 None 5 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 310 4 2 2 2.6 COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.04.013
44429443 152123 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 6 2 2 2.9 CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL391350 152123 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 6 2 2 2.9 CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
44264871 211809 0 None 26 2 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 297 5 1 3 4.2 CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7700 211809 0 None 26 2 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 297 5 1 3 4.2 CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
52918080 67538 0 None 13 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 287 4 1 4 2.1 COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 10.1016/j.bmcl.2011.02.097
CHEMBL1760957 67538 0 None 13 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 287 4 1 4 2.1 COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 10.1016/j.bmcl.2011.02.097
9884156 214655 0 None 77 2 Human 9.2 pKi = 9.2 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 335 7 1 3 3.9 C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL96548 214655 0 None 77 2 Human 9.2 pKi = 9.2 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 335 7 1 3 3.9 C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 10.1021/jm0005252
164946945 197008 1 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5174929 197008 1 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
1357 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2005.01.015
1672 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2005.01.015
224 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2005.01.015
896 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2005.01.015
CHEMBL45 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2005.01.015
DB01065 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2005.01.015
127029516 144412 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758225 144412 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 269 3 1 3 3.2 COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 10.1016/j.ejmech.2015.12.047
127025784 144511 0 None 8 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759084 144511 0 None 8 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 10.1016/j.ejmech.2015.12.047
15453084 93185 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 255 3 1 2 2.8 COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1 10.1016/j.bmcl.2012.11.069
CHEMBL2314251 93185 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 255 3 1 2 2.8 COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1 10.1016/j.bmcl.2012.11.069
1357 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.07.055
1672 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.07.055
224 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.07.055
896 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.07.055
CHEMBL45 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.07.055
DB01065 9263 139 None 1 9 Human 9.2 pKi = 9.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmcl.2004.07.055
44264904 212400 0 None 57 2 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 295 5 1 2 4.0 CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL8169 212400 0 None 57 2 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 295 5 1 2 4.0 CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
12985492 188610 0 None 177 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 459 6 1 2 5.1 COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL477833 188610 0 None 177 2 Human 9.2 pKi = 9.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 459 6 1 2 5.1 COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
11681026 83915 0 None 11 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 302 6 1 3 3.4 CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
CHEMBL207745 83915 0 None 11 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 302 6 1 3 3.4 CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
1357 9263 139 None 1 9 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.07.012
1672 9263 139 None 1 9 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.07.012
224 9263 139 None 1 9 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.07.012
896 9263 139 None 1 9 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.07.012
CHEMBL45 9263 139 None 1 9 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.07.012
DB01065 9263 139 None 1 9 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2008.07.012
9947753 211679 0 None 83 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7599 211679 0 None 83 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
44264949 211747 0 None 83 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 299 7 1 3 4.6 CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7650 211747 0 None 83 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 299 7 1 3 4.6 CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
44272422 174658 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 288 5 2 3 3.1 CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL431103 174658 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 288 5 2 3 3.1 CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 10.1016/j.bmcl.2003.12.052
59145872 192955 0 None -2 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 257 3 1 3 2.1 CC(=O)NCCC1CCc2ccc3nn(C)cc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4872592 192955 0 None -2 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 257 3 1 3 2.1 CC(=O)NCCC1CCc2ccc3nn(C)cc3c21 10.1021/acs.jmedchem.0c01836
10750842 195461 3 None 30 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 207 5 1 2 1.8 COc1cccc(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL50398 195461 3 None 30 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 207 5 1 2 1.8 COc1cccc(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
24750069 157262 0 None 66 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 298 7 1 3 2.8 COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1 10.1021/jm700957j
CHEMBL395437 157262 0 None 66 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 298 7 1 3 2.8 COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1 10.1021/jm700957j
53238411 68803 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 375 4 1 2 4.9 CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
CHEMBL1774530 68803 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
ChEMBL 375 4 1 2 4.9 CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3 10.1021/jm200221q
10873443 202003 4 None 1 2 Human 9.1 pKi = 9.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 417 5 1 5 2.4 COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL55084 202003 4 None 1 2 Human 9.1 pKi = 9.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 417 5 1 5 2.4 COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-] 10.1021/jm011053+
44264909 212013 0 None 117 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 293 5 1 2 4.8 CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7875 212013 0 None 117 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 293 5 1 2 4.8 CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1 10.1016/j.bmcl.2003.11.030
137641357 163858 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.1 CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4074273 163858 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.1 CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
9817636 27447 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 295 4 1 2 3.4 COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1 10.1021/jm000922c
CHEMBL130876 27447 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 295 4 1 2 3.4 COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1 10.1021/jm000922c
44272443 202266 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 6 2 3 3.5 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
CHEMBL553105 202266 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 6 2 3 3.5 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
139451790 192075 18 None 2 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 297 5 1 5 1.8 COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4859295 192075 18 None 2 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 297 5 1 5 1.8 COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O 10.1021/acs.jmedchem.0c00627
127025788 144545 0 None 53 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 300 3 2 3 3.2 CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
CHEMBL3759372 144545 0 None 53 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 300 3 2 3 3.2 CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
145983929 173200 0 None 6 3 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 4 1 3 2.8 COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4277185 173200 0 None 6 3 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 4 1 3 2.8 COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
1348 8626 5 None 100 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 10.1021/jm401343c
44208891 8626 5 None 100 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 10.1021/jm401343c
CHEMBL3260983 8626 5 None 100 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 10.1021/jm401343c
57381112 8198 0 None -20 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 279 5 1 2 2.8 COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 10.1039/C5MD00190K
7776 8198 0 None -20 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 279 5 1 2 2.8 COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 10.1039/C5MD00190K
CHEMBL1946221 8198 0 None -20 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 279 5 1 2 2.8 COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 10.1039/C5MD00190K
57381112 8198 0 None -20 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 279 5 1 2 2.8 COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 10.1039/C5MD00190K
7776 8198 0 None -20 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 279 5 1 2 2.8 COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 10.1039/C5MD00190K
CHEMBL1946221 8198 0 None -20 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 279 5 1 2 2.8 COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 10.1039/C5MD00190K
11536939 83889 0 None 12 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 314 6 1 3 3.5 CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 10.1021/jm0512544
CHEMBL207625 83889 0 None 12 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 314 6 1 3 3.5 CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 10.1021/jm0512544
53231366 69175 0 None 66 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 5 1 3 5.0 CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779804 69175 0 None 66 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 5 1 3 5.0 CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
24750188 156023 0 None 114 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 314 7 1 4 3.0 COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1 10.1021/jm700957j
CHEMBL394430 156023 0 None 114 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 314 7 1 4 3.0 COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1 10.1021/jm700957j
44272440 74300 0 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 260 4 2 3 2.5 CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL18960 74300 0 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 260 4 2 3 2.5 CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 10.1016/j.bmcl.2003.12.052
11426853 173147 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 309 3 1 3 2.7 COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O 10.1021/jm040768k
CHEMBL427516 173147 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 309 3 1 3 2.7 COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O 10.1021/jm040768k
10044270 196323 0 None 891 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 1 2 4.8 COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2 10.1021/jm800974d
CHEMBL514280 196323 0 None 891 2 Human 9.1 pKi = 9.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 1 2 4.8 COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2 10.1021/jm800974d
139451757 191610 0 None -1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 311 6 1 5 2.2 CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4852096 191610 0 None -1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 311 6 1 5 2.2 CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
139451795 192108 0 None -2 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 277 6 1 5 1.6 CCOc1nc2ccc(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4859677 192108 0 None -2 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 277 6 1 5 1.6 CCOc1nc2ccc(OC)cc2n1CCNC(C)=O 10.1021/acs.jmedchem.0c00627
24954992 70572 0 None -1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 313 3 1 4 2.0 CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 10.1021/jm200385u
CHEMBL1802029 70572 0 None -1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 313 3 1 4 2.0 CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 10.1021/jm200385u
44358274 35726 0 None -1 2 Human 9.0 pKi = 9.0 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 261 2 2 3 1.1 CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL138012 35726 0 None -1 2 Human 9.0 pKi = 9.0 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 261 2 2 3 1.1 CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
44579163 188908 0 None 53 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 362 6 1 3 4.3 COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL478217 188908 0 None 53 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 362 6 1 3 4.3 COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
10712600 11130 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 346 5 1 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 10.1021/jm980684+
CHEMBL10110 11130 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 346 5 1 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 10.1021/jm980684+
1357 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1672 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
224 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
896 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
CHEMBL45 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
DB01065 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 1 hr by gamma counting method
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
12985493 193871 0 None 213 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 7 1 3 4.3 COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
CHEMBL491403 193871 0 None 213 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 7 1 3 4.3 COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
25025104 193094 0 None -5 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 271 4 1 3 2.6 CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4874630 193094 0 None -5 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 271 4 1 3 2.6 CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21 10.1021/acs.jmedchem.0c01836
1357 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C1MD00149C
1672 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C1MD00149C
224 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C1MD00149C
896 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C1MD00149C
CHEMBL45 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C1MD00149C
DB01065 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C1MD00149C
1357 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
1672 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
224 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
896 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
CHEMBL45 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
DB01065 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1039/C5MD00190K
1357 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm800974d
1672 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm800974d
224 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm800974d
896 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm800974d
CHEMBL45 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm800974d
DB01065 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1021/jm800974d
1357 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2009.04.068
1672 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2009.04.068
224 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2009.04.068
896 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2009.04.068
CHEMBL45 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2009.04.068
DB01065 9263 139 None 1 9 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.bmc.2009.04.068
10061064 109745 0 None 7 2 Human 9.0 pKi = 9.0 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 258 5 1 3 2.3 CCC(=O)NCCc1ccnc2ccc(OC)cc12 10.1016/S0960-894X(97)00392-2
CHEMBL306468 109745 0 None 7 2 Human 9.0 pKi = 9.0 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 258 5 1 3 2.3 CCC(=O)NCCc1ccnc2ccc(OC)cc12 10.1016/S0960-894X(97)00392-2
23658144 164958 1 None 6 3 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
CHEMBL4087633 164958 1 None 6 3 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
44358184 123318 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 246 2 1 3 1.3 CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL336268 123318 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 246 2 1 3 1.3 CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
10015475 23535 0 None 3 2 Human 9.0 pKi = 9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 6 1 3 2.8 CCC(=O)NCCCc1cccc2nc(CC)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL124362 23535 0 None 3 2 Human 9.0 pKi = 9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 6 1 3 2.8 CCC(=O)NCCCc1cccc2nc(CC)oc12 10.1016/j.bmcl.2004.04.082
9970584 23543 0 None 8 2 Human 9.0 pKi = 9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 7 1 3 3.2 CCCC(=O)NCCCc1cccc2nc(CC)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL124422 23543 0 None 8 2 Human 9.0 pKi = 9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 7 1 3 3.2 CCCC(=O)NCCCc1cccc2nc(CC)oc12 10.1016/j.bmcl.2004.04.082
44272444 74721 0 None 3 2 Human 9.0 pKi = 9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 303 6 3 3 3.0 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL19109 74721 0 None 3 2 Human 9.0 pKi = 9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 303 6 3 3 3.0 CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1 10.1016/j.bmcl.2003.12.052
137636079 163006 0 None 19 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 232 3 1 2 1.8 CCN1CC(CNC(C)=O)Cc2ccccc21 10.1021/acs.jmedchem.8b00359
CHEMBL4064626 163006 0 None 19 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 232 3 1 2 1.8 CCN1CC(CNC(C)=O)Cc2ccccc21 10.1021/acs.jmedchem.8b00359
137645887 164719 0 None 58 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 294 4 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4084568 164719 0 None 58 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 294 4 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
86273226 128096 0 None 5 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 256 5 2 2 1.9 C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580908 128096 0 None 5 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 256 5 2 2 1.9 C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
137660726 166111 0 None 15 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 322 6 1 5 1.6 CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
CHEMBL4100108 166111 0 None 15 2 Human 9.0 pKi = 9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 322 6 1 5 1.6 CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12 10.1016/j.ejmech.2016.12.013
11550834 146322 0 None 4 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 5 1 3 2.8 CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
CHEMBL379616 146322 0 None 4 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 5 1 3 2.8 CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
44429442 157002 0 None 1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 5 2 2 2.6 CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL395221 157002 0 None 1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 5 2 2 2.6 CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
25210130 6857 0 None 91 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 10.1021/jm800974d
7782 6857 0 None 91 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 10.1021/jm800974d
CHEMBL514415 6857 0 None 91 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 10.1021/jm800974d
57781248 191342 0 None 1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 274 4 2 4 1.9 CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4848381 191342 0 None 1 2 Human 9.0 pKi = 9.0 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 274 4 2 4 1.9 CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21 10.1021/acs.jmedchem.0c01836
11507534 172912 0 None 5 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 288 5 1 3 3.0 CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
CHEMBL426127 172912 0 None 5 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 288 5 1 3 3.0 CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 10.1021/jm0512544
11784134 113726 0 None 67 2 Human 8.9 pKi = 8.9 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 391 6 1 3 4.7 COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL314947 113726 0 None 67 2 Human 8.9 pKi = 8.9 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 391 6 1 3 4.7 COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
25210130 6857 0 None 91 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 10.1021/jm800974d
7782 6857 0 None 91 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 10.1021/jm800974d
CHEMBL514415 6857 0 None 91 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 10.1021/jm800974d
44272431 105633 0 None 4 2 Human 8.9 pKi = 8.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 274 4 2 3 2.7 CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
CHEMBL278922 105633 0 None 4 2 Human 8.9 pKi = 8.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 274 4 2 3 2.7 CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
19703015 144676 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 234 4 1 4 1.5 COc1ccc2occ(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3763281 144676 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 234 4 1 4 1.5 COc1ccc2occ(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
10754723 175977 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 273 5 2 3 2.6 CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL440692 175977 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 273 5 2 3 2.6 CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
44317845 212285 0 None -3 2 Human 8.9 pKi = 8.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 301 7 1 3 3.3 CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC 10.1016/S0960-894X(97)00444-7
CHEMBL80736 212285 0 None -3 2 Human 8.9 pKi = 8.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 301 7 1 3 3.3 CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC 10.1016/S0960-894X(97)00444-7
11587169 84092 0 None 8 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 4 1 3 2.6 COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C 10.1021/jm0512544
CHEMBL208307 84092 0 None 8 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 4 1 3 2.6 COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C 10.1021/jm0512544
127039212 144805 0 None 154 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 360 5 1 4 4.3 COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3764879 144805 0 None 154 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 360 5 1 4 4.3 COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
10495702 212014 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 317 8 2 4 2.3 CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL78751 212014 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 317 8 2 4 2.3 CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
44429449 94138 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 324 4 1 3 2.6 COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C 10.1016/j.bmc.2007.04.013
CHEMBL233309 94138 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 324 4 1 3 2.6 COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C 10.1016/j.bmc.2007.04.013
44429446 153510 0 None 14 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 288 6 1 3 3.0 CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL392422 153510 0 None 14 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 288 6 1 3 3.0 CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
137641357 163858 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.1 CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4074273 163858 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.1 CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
10399579 210762 0 None 4 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 244 4 1 3 1.9 COc1ccc2nccc(CCNC(C)=O)c2c1 10.1016/S0960-894X(97)00392-2
CHEMBL69521 210762 0 None 4 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
ChEMBL 244 4 1 3 1.9 COc1ccc2nccc(CCNC(C)=O)c2c1 10.1016/S0960-894X(97)00392-2
139451769 192921 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC 10.1021/acs.jmedchem.0c00627
CHEMBL4872217 192921 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC 10.1021/acs.jmedchem.0c00627
59145922 193051 0 None -7 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 257 3 1 3 2.2 CC(=O)NCCC1CCc2ccn3nc(C)cc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL4874010 193051 0 None -7 2 Human 8.9 pKi = 8.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 257 3 1 3 2.2 CC(=O)NCCC1CCc2ccn3nc(C)cc3c21 10.1021/acs.jmedchem.0c01836
44426096 92511 0 None 4 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 211 2 1 1 2.9 CC(=O)N/C=C/c1cccc2ccccc12 10.1016/j.bmcl.2012.11.069
CHEMBL229015 92511 0 None 4 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 211 2 1 1 2.9 CC(=O)N/C=C/c1cccc2ccccc12 10.1016/j.bmcl.2012.11.069
10737372 11404 0 None 37 2 Human 8.9 pKi = 8.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 5 1 3 4.3 CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2 10.1021/jm980684+
CHEMBL10293 11404 0 None 37 2 Human 8.9 pKi = 8.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 5 1 3 4.3 CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2 10.1021/jm980684+
1358 6912 41 None 870 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm401343c
3976006 6912 41 None 870 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm401343c
CHEMBL285718 6912 41 None 870 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 10.1021/jm401343c
9819843 214917 0 None 20 2 Human 8.8 pKi = 8.8 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 351 8 1 3 4.3 COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL98074 214917 0 None 20 2 Human 8.8 pKi = 8.8 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 351 8 1 3 4.3 COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
16094594 90021 0 None 165 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 321 6 1 2 4.0 COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm060850a
CHEMBL218709 90021 0 None 165 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 321 6 1 2 4.0 COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm060850a
44429444 153509 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.2 COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C 10.1016/j.bmc.2007.04.013
CHEMBL392421 153509 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 1 3 2.2 COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C 10.1016/j.bmc.2007.04.013
10640828 28254 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 339 6 1 3 3.8 COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1 10.1021/jm000922c
CHEMBL131575 28254 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 339 6 1 3 3.8 COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1 10.1021/jm000922c
46885284 14877 0 None 114 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 251 7 1 3 2.2 CCOc1ccc(OC)cc1CCCNC(C)=O 10.1016/j.bmcl.2010.02.084
CHEMBL1091561 14877 0 None 114 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 251 7 1 3 2.2 CCOc1ccc(OC)cc1CCCNC(C)=O 10.1016/j.bmcl.2010.02.084
139451766 191226 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 325 7 1 5 2.6 CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4846505 191226 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 325 7 1 5 2.6 CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
10831675 28552 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 349 7 1 4 3.1 CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12 10.1021/jm970437q
CHEMBL131919 28552 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
ChEMBL 349 7 1 4 3.1 CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12 10.1021/jm970437q
46884552 14899 0 None 1122 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 314 8 1 4 2.7 COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1091716 14899 0 None 1122 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 314 8 1 4 2.7 COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
10567865 10950 0 None 38 2 Human 8.8 pKi = 8.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 322 6 1 3 3.7 CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1 10.1021/jm001125h
CHEMBL100104 10950 0 None 38 2 Human 8.8 pKi = 8.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 322 6 1 3 3.7 CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1 10.1021/jm001125h
46865422 93846 0 None 575 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1039/C1MD00149C
CHEMBL2326199 93846 0 None 575 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1039/C1MD00149C
12324 10683 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 591 13 3 4 7.0 O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 10.1021/acs.jmedchem.8b00893
145966622 10683 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 591 13 3 4 7.0 O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 10.1021/acs.jmedchem.8b00893
CHEMBL4210086 10683 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 591 13 3 4 7.0 O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 10.1021/acs.jmedchem.8b00893
11068422 214623 0 None 7 2 Human 8.8 pKi = 8.8 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 361 6 1 4 4.7 COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1 10.1021/jm0005252
CHEMBL96420 214623 0 None 7 2 Human 8.8 pKi = 8.8 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 361 6 1 4 4.7 COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1 10.1021/jm0005252
127026424 144470 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 283 4 1 3 3.3 COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3758720 144470 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 283 4 1 3 3.3 COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1 10.1016/j.ejmech.2015.12.047
46865422 93846 0 None 575 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1016/j.ejmech.2016.01.008
CHEMBL2326199 93846 0 None 575 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 357 10 1 4 3.7 CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 10.1016/j.ejmech.2016.01.008
11776674 123427 1 None 1 2 Human 8.8 pKi = 8.8 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 246 4 1 3 1.9 COc1ccc2c(c1)c(CCNC(C)=O)cn2C 10.1021/jm020982d
CHEMBL33700 123427 1 None 1 2 Human 8.8 pKi = 8.8 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 246 4 1 3 1.9 COc1ccc2c(c1)c(CCNC(C)=O)cn2C 10.1021/jm020982d
44429441 93501 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 246 4 2 2 2.2 COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.04.013
CHEMBL231872 93501 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 246 4 2 2 2.2 COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.04.013
9914839 104932 0 None -34 2 Human 8.8 pKi = 8.8 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 526 14 2 4 6.0 CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
CHEMBL273787 104932 0 None -34 2 Human 8.8 pKi = 8.8 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 526 14 2 4 6.0 CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
10424693 116420 1 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 297 4 1 2 3.1 COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 10.1039/C5MD00190K
CHEMBL322339 116420 1 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 297 4 1 2 3.1 COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 10.1039/C5MD00190K
127038129 143650 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 311 5 1 2 3.3 COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 10.1039/C5MD00190K
CHEMBL3742090 143650 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 311 5 1 2 3.3 COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 10.1039/C5MD00190K
22718564 23552 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 5 1 3 2.3 CCC(=O)NCCCc1cccc2ncoc12 10.1016/j.bmcl.2004.04.082
CHEMBL124476 23552 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 5 1 3 2.3 CCC(=O)NCCCc1cccc2ncoc12 10.1016/j.bmcl.2004.04.082
44264706 211209 1 None 33 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 270 5 2 3 3.8 CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7215 211209 1 None 33 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 270 5 2 3 3.8 CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
46888521 15416 0 None -26 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 499 12 1 5 5.6 COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095196 15416 0 None -26 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 499 12 1 5 5.6 COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
10611901 30348 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 267 5 1 1 3.8 CCCC(=O)NCCC1Cc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL133426 30348 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 267 5 1 1 3.8 CCCC(=O)NCCC1Cc2cccc3cccc1c23 10.1021/jm000922c
10729569 123334 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 253 4 1 1 3.4 CCC(=O)NCCC1Cc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL336333 123334 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 253 4 1 1 3.4 CCC(=O)NCCC1Cc2cccc3cccc1c23 10.1021/jm000922c
12985489 197015 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL517502 197015 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
44272305 74097 0 None -14 2 Human 8.7 pKi = 8.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 392 9 2 3 5.1 CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 10.1016/j.bmcl.2003.12.052
CHEMBL18845 74097 0 None -14 2 Human 8.7 pKi = 8.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 392 9 2 3 5.1 CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 10.1016/j.bmcl.2003.12.052
24750193 95328 1 None -2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 236 6 1 3 1.7 COc1cccc(N(C)CCCNC(C)=O)c1 10.1021/jm700957j
CHEMBL235329 95328 1 None -2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 236 6 1 3 1.7 COc1cccc(N(C)CCCNC(C)=O)c1 10.1021/jm700957j
168274836 196926 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5173623 196926 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
22718610 23660 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 308 6 1 3 4.0 CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL125033 23660 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 308 6 1 3 4.0 CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
9797715 211719 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 333 6 1 4 3.3 CCCC(=O)Nc1ccc(S(=O)(=O)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7637 211719 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 333 6 1 4 3.3 CCCC(=O)Nc1ccc(S(=O)(=O)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL3109563 217870 0 None 3 2 Human 8.0 pKi = 8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins
ChEMBL None None None COc1ccc2c(c1)c(CCNC(C)=O)c1n2[B-](F)(F)[N+]2=C(C)C=C(C)C2=C1 10.1021/ml4004155
10545399 212291 0 None 4 2 Human 8.0 pKi = 8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 344 9 1 4 2.9 CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL80792 212291 0 None 4 2 Human 8.0 pKi = 8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 344 9 1 4 2.9 CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
44394435 73701 0 None -3 2 Human 8.0 pKi = 8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 361 8 1 2 5.2 CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL186586 73701 0 None -3 2 Human 8.0 pKi = 8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 361 8 1 2 5.2 CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
44394415 131185 0 None -1 2 Human 8.0 pKi = 8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 389 10 1 2 6.0 CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL363947 131185 0 None -1 2 Human 8.0 pKi = 8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 389 10 1 2 6.0 CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
122162 9166 75 None 18 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1021/jm401343c
1363 9166 75 None 18 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1021/jm401343c
CHEMBL286615 9166 75 None 18 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1021/jm401343c
11066802 106863 0 None 21 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 308 5 1 3 3.7 CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1 10.1021/jm001125h
CHEMBL287343 106863 0 None 21 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 308 5 1 3 3.7 CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1 10.1021/jm001125h
11098363 175895 1 None 14 2 Human 8.0 pKi = 8.0 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 293 5 1 2 3.7 CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12 10.1021/jm0005252
CHEMBL440144 175895 1 None 14 2 Human 8.0 pKi = 8.0 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 293 5 1 2 3.7 CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12 10.1021/jm0005252
53231464 69180 0 None 21 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 375 6 1 3 5.2 C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779809 69180 0 None 21 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 375 6 1 3 5.2 C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
44358275 175232 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 287 3 2 3 1.7 O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL435023 175232 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 287 3 2 3 1.7 O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
9937825 15640 0 None -12 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 564 17 2 4 6.7 C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1097315 15640 0 None -12 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 564 17 2 4 6.7 C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 10.1016/j.bmc.2010.04.008
56661512 71221 0 None -23 2 Human 6.0 pKi = 6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 470 15 2 6 3.1 CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813319 71221 0 None -23 2 Human 6.0 pKi = 6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 470 15 2 6 3.1 CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
11681201 147854 0 None 2 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 314 5 1 3 3.5 CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 10.1021/jm0512544
CHEMBL382555 147854 0 None 2 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 314 5 1 3 3.5 CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 10.1021/jm0512544
46884550 14956 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 409 8 1 3 4.2 COc1ccc(OCc2ccc(Br)cc2F)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1091997 14956 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 409 8 1 3 4.2 COc1ccc(OCc2ccc(Br)cc2F)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
44412079 173036 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 4 2 3 2.8 CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 10.1021/jm0512544
CHEMBL426861 173036 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 4 2 3 2.8 CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 10.1021/jm0512544
46884599 15191 0 None 13 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 343 9 1 4 3.4 COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1093457 15191 0 None 13 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 343 9 1 4 3.4 COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1 10.1016/j.bmcl.2010.02.084
9795837 168578 4 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1ccc(Oc2ccccc2OC)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL414212 168578 4 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1ccc(Oc2ccccc2OC)cc1 10.1016/j.bmcl.2003.11.030
162661094 188222 3 None 10 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4764211 188222 3 None 10 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
49865203 22621 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(O[C@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223049 22621 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(O[C@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
54583162 67535 0 None 7 2 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 276 6 2 5 0.9 CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12 10.1016/j.bmcl.2011.02.097
CHEMBL1760954 67535 0 None 7 2 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 276 6 2 5 0.9 CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12 10.1016/j.bmcl.2011.02.097
11208578 132667 0 None 1 2 Human 5.0 pKi = 5.0 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 292 2 1 2 3.0 CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21 10.1021/jm040768k
CHEMBL364845 132667 0 None 1 2 Human 5.0 pKi = 5.0 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 292 2 1 2 3.0 CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21 10.1021/jm040768k
139451776 191790 0 None -5 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 277 6 1 5 1.6 COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
CHEMBL4854836 191790 0 None -5 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 277 6 1 5 1.6 COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
127025781 144602 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759859 144602 0 None 6 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 10.1016/j.ejmech.2015.12.047
18007985 15488 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 538 14 2 4 6.0 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095832 15488 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 538 14 2 4 6.0 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12 10.1016/j.bmc.2010.04.008
16094582 90089 5 None 44 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 251 4 1 1 3.3 CC(=O)NCC=C(c1ccccc1)c1ccccc1 10.1021/jm060850a
CHEMBL219076 90089 5 None 44 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 251 4 1 1 3.3 CC(=O)NCC=C(c1ccccc1)c1ccccc1 10.1021/jm060850a
16743295 99964 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 284 6 1 2 3.4 CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2 10.1016/j.ejmech.2007.01.005
CHEMBL244472 99964 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 284 6 1 2 3.4 CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2 10.1016/j.ejmech.2007.01.005
9860588 26718 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 4 1 2 3.4 COc1ccc2cccc3c2c1CCC3CCNC(C)=O 10.1021/jm000922c
CHEMBL130286 26718 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 4 1 2 3.4 COc1ccc2cccc3c2c1CCC3CCNC(C)=O 10.1021/jm000922c
46888492 15615 0 None -18 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 564 14 2 5 6.5 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1096991 15615 0 None -18 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 564 14 2 5 6.5 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12 10.1016/j.bmc.2010.04.008
44264964 212045 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 281 5 1 3 3.4 C#CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7898 212045 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 281 5 1 3 3.4 C#CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
130400672 163775 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 204 2 2 2 1.4 CC(=O)NCC1CNc2ccccc2C1 10.1021/acs.jmedchem.8b00359
CHEMBL4073210 163775 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 204 2 2 2 1.4 CC(=O)NCC1CNc2ccccc2C1 10.1021/acs.jmedchem.8b00359
162673578 189897 0 None 5 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 272 5 2 5 2.4 CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1 10.1016/j.ejmech.2020.112090
CHEMBL4794879 189897 0 None 5 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 272 5 2 5 2.4 CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1 10.1016/j.ejmech.2020.112090
1362 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm0255872
9870523 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm0255872
CHEMBL429392 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm0255872
1362 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
9870523 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
CHEMBL429392 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
1362 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
9870523 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
CHEMBL429392 10210 22 None -39 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
10544425 215116 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 330 4 1 2 4.1 O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1 10.1021/jm980684+
CHEMBL9934 215116 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 330 4 1 2 4.1 O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1 10.1021/jm980684+
44349270 119869 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 286 6 1 3 3.4 CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL331317 119869 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 286 6 1 3 3.4 CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
10893437 215228 0 None 6 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 348 6 1 3 4.1 COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1 10.1021/jm001125h
CHEMBL99987 215228 0 None 6 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 348 6 1 3 4.1 COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1 10.1021/jm001125h
12436515 22604 2 None 1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)NCC(C)Oc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1222985 22604 2 None 1 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)NCC(C)Oc1ccccc1 10.1016/j.bmc.2010.06.100
86079062 187511 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2ncnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4755860 187511 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2ncnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
10666373 105097 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 5 1 3 4.3 CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL274995 105097 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 362 5 1 3 4.3 CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 10.1021/jm980684+
19703063 35688 1 None -2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 2 3 1.2 COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 10.1016/j.bmcl.2011.02.097
CHEMBL137969 35688 1 None -2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 233 4 2 3 1.2 COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 10.1016/j.bmcl.2011.02.097
19703063 35688 1 None -2 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 2 3 1.2 COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 10.1016/j.ejmech.2016.01.008
CHEMBL137969 35688 1 None -2 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 2 3 1.2 COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 10.1016/j.ejmech.2016.01.008
25210135 181703 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 378 6 3 4 3.0 COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL456505 181703 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 378 6 3 4 3.0 COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
25210135 181703 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 378 6 3 4 3.0 COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL456505 181703 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 378 6 3 4 3.0 COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
44349171 23427 1 None 6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 275 6 2 3 2.6 CCNC(=O)NCCCc1cccc2nc(CC)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL124217 23427 1 None 6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 275 6 2 3 2.6 CCNC(=O)NCCCc1cccc2nc(CC)oc12 10.1016/j.bmcl.2004.04.082
10738183 11149 0 None 41 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 374 5 1 3 4.3 COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL10124 11149 0 None 41 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 374 5 1 3 4.3 COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 10.1021/jm980684+
10591657 11448 0 None 14 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 318 5 1 2 4.1 CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 10.1021/jm980684+
CHEMBL10328 11448 0 None 14 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 318 5 1 2 4.1 CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 10.1021/jm980684+
162674428 190059 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 273 4 2 4 2.2 COc1ccc2[nH]cc(CC(C)c3n[nH]c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
CHEMBL4796759 190059 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 273 4 2 4 2.2 COc1ccc2[nH]cc(CC(C)c3n[nH]c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
44436051 158142 6 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 209 5 1 3 1.2 COc1cccc(OCCNC(C)=O)c1 10.1021/jm700957j
CHEMBL396132 158142 6 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 209 5 1 3 1.2 COc1cccc(OCCNC(C)=O)c1 10.1021/jm700957j
44272424 75850 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 289 4 3 3 2.5 CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
CHEMBL19237 75850 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 289 4 3 3 2.5 CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
46884598 14962 0 None 20 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 223 5 2 3 1.5 COc1cc(CCCNC(C)=O)ccc1O 10.1016/j.bmcl.2010.02.084
CHEMBL1092047 14962 0 None 20 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 223 5 2 3 1.5 COc1cc(CCCNC(C)=O)ccc1O 10.1016/j.bmcl.2010.02.084
9930390 214659 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 391 6 1 3 5.0 COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL96562 214659 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 391 6 1 3 5.0 COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1 10.1021/jm0005252
10991315 215074 0 None 23 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 336 7 1 3 4.1 CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1 10.1021/jm001125h
CHEMBL99001 215074 0 None 23 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 336 7 1 3 4.1 CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1 10.1021/jm001125h
49865268 22649 0 None -13 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 249 6 1 3 2.0 COc1cccc(OC(C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223128 22649 0 None -13 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 249 6 1 3 2.0 COc1cccc(OC(C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
44358088 33554 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 246 2 1 3 1.3 CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL136273 33554 0 None 1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 246 2 1 3 1.3 CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
46884555 15114 0 None 16 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 327 9 1 3 3.7 CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1092911 15114 0 None 16 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 327 9 1 3 3.7 CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1 10.1016/j.bmcl.2010.02.084
9903953 211816 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 5 1 3 4.1 COc1cccc(Oc2ccc(NC(=O)C(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7703 211816 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 5 1 3 4.1 COc1cccc(Oc2ccc(NC(=O)C(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
10705590 214986 0 None 1 2 Human 5.9 pKi = 5.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 246 4 1 3 1.9 COc1ccc2cc(CCNC(C)=O)n(C)c2c1 10.1021/jm001125h
CHEMBL98484 214986 0 None 1 2 Human 5.9 pKi = 5.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 246 4 1 3 1.9 COc1ccc2cc(CCNC(C)=O)n(C)c2c1 10.1021/jm001125h
49865377 22706 0 None -1 2 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SC[C@@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223280 22706 0 None -1 2 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SC[C@@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
11403195 130457 1 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 278 3 1 2 3.4 CC(=O)NCCN1c2ccccc2C=Cc2ccccc21 10.1021/jm040768k
CHEMBL362133 130457 1 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 278 3 1 2 3.4 CC(=O)NCCN1c2ccccc2C=Cc2ccccc21 10.1021/jm040768k
49865147 22602 2 None 3 2 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1ccc(OC(C)CNC(C)=O)cc1 10.1016/j.bmc.2010.06.100
CHEMBL1222983 22602 2 None 3 2 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1ccc(OC(C)CNC(C)=O)cc1 10.1016/j.bmc.2010.06.100
44412078 146295 0 None 1 2 Human 5.9 pKi = 5.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 272 3 2 3 2.4 CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 10.1021/jm0512544
CHEMBL379504 146295 0 None 1 2 Human 5.9 pKi = 5.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 272 3 2 3 2.4 CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 10.1021/jm0512544
18522208 134064 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 349 9 1 2 5.1 CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL365852 134064 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 349 9 1 2 5.1 CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
145974583 171269 0 None -4 2 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 279 9 2 4 1.4 CC(=O)NCCN(C)c1cccc(OCCCCN)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4214348 171269 0 None -4 2 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 279 9 2 4 1.4 CC(=O)NCCN(C)c1cccc(OCCCCN)c1 10.1021/acs.jmedchem.8b00893
18702059 211776 4 None 7 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 283 5 1 3 3.8 COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7673 211776 4 None 7 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 283 5 1 3 3.8 COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1 10.1016/j.bmcl.2003.11.030
16094583 172919 3 None 69 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 291 5 1 1 4.0 O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1 10.1021/jm060850a
CHEMBL426168 172919 3 None 69 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 291 5 1 1 4.0 O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1 10.1021/jm060850a
10542922 123370 0 None -6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 309 5 1 2 3.8 COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1 10.1021/jm000922c
CHEMBL336633 123370 0 None -6 2 Human 7.9 pKi = 7.9 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 309 5 1 2 3.8 COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1 10.1021/jm000922c
127026426 144578 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759606 144578 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 309 5 1 3 3.7 COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
46885286 14940 0 None 218 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 327 9 1 3 3.4 COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1091895 14940 0 None 218 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 327 9 1 3 3.4 COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
9850873 15639 0 None -13 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 564 15 2 4 6.4 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 10.1016/j.bmc.2010.04.008
CHEMBL1097314 15639 0 None -13 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 564 15 2 4 6.4 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 10.1016/j.bmc.2010.04.008
44359437 36673 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 273 5 2 3 2.1 COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 10.1039/C4MD00149D
CHEMBL138807 36673 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 273 5 2 3 2.1 COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 10.1039/C4MD00149D
168274836 196926 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5173623 196926 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 411 7 1 7 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
9870683 15661 0 None -9 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 502 13 2 5 5.2 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1097496 15661 0 None -9 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 502 13 2 5 5.2 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
9860638 212533 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1ccccc1Oc1cccc(OC)c1 10.1016/j.bmcl.2003.11.030
CHEMBL8278 212533 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1ccccc1Oc1cccc(OC)c1 10.1016/j.bmcl.2003.11.030
49865376 22705 2 None 9 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SCC(C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223279 22705 2 None 9 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SCC(C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
10447987 123747 2 None 1 2 Human 6.9 pKi = 6.9 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 308 5 1 3 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1 10.1021/jm020982d
CHEMBL33869 123747 2 None 1 2 Human 6.9 pKi = 6.9 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 308 5 1 3 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1 10.1021/jm020982d
162663385 188777 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 271 5 1 4 1.7 COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4780509 188777 0 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 271 5 1 4 1.7 COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2020.112078
11573203 147856 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 312 5 1 3 3.1 COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C 10.1021/jm0512544
CHEMBL382579 147856 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 312 5 1 3 3.1 COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C 10.1021/jm0512544
10361427 119648 0 None -18 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 364 10 1 3 4.9 CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL330969 119648 0 None -18 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 364 10 1 3 4.9 CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
25209860 195762 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.8 COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL508552 195762 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.8 COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 10.1021/jm800974d
44394532 74020 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 376 7 1 3 4.7 CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
CHEMBL188016 74020 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 376 7 1 3 4.7 CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
25209860 195762 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.8 COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL508552 195762 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.8 COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 10.1021/jm800974d
44424017 92098 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 592 14 4 8 3.4 COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL226112 92098 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 592 14 4 8 3.4 COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
127041170 143467 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 584 15 2 4 6.1 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
CHEMBL3740377 143467 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 584 15 2 4 6.1 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
25210131 182094 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 7 2 3 3.8 CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 10.1021/jm800974d
CHEMBL457352 182094 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 7 2 3 3.8 CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 10.1021/jm800974d
25210131 182094 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 7 2 3 3.8 CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 10.1021/jm800974d
CHEMBL457352 182094 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 7 2 3 3.8 CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 10.1021/jm800974d
25210133 196340 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.7 COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL514427 196340 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.7 COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
11058163 214993 0 None 22 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 386 5 1 3 4.1 COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1 10.1021/jm001125h
CHEMBL98520 214993 0 None 22 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 386 5 1 3 4.1 COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1 10.1021/jm001125h
5151463 90108 12 None 29 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 253 5 1 1 3.3 CC(=O)NCCC(c1ccccc1)c1ccccc1 10.1021/jm060850a
CHEMBL219177 90108 12 None 29 2 Human 6.9 pKi = 6.9 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 253 5 1 1 3.3 CC(=O)NCCC(c1ccccc1)c1ccccc1 10.1021/jm060850a
10903463 215143 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 324 5 2 2 3.0 CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br 10.1021/jm001125h
CHEMBL99502 215143 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 324 5 2 2 3.0 CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br 10.1021/jm001125h
44412063 84363 0 None -2 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 298 4 2 3 2.8 Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21 10.1021/jm0512544
CHEMBL208802 84363 0 None -2 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 298 4 2 3 2.8 Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21 10.1021/jm0512544
10609620 215088 1 None 5 2 Human 5.8 pKi = 5.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2cc(CCNC(C)=O)[nH]c2c1 10.1021/jm001125h
CHEMBL99091 215088 1 None 5 2 Human 5.8 pKi = 5.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2cc(CCNC(C)=O)[nH]c2c1 10.1021/jm001125h
16094578 90047 1 None 8 2 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 251 4 1 1 3.4 CC(=O)NC/C(=C\c1ccccc1)c1ccccc1 10.1021/jm060850a
CHEMBL218808 90047 1 None 8 2 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 251 4 1 1 3.4 CC(=O)NC/C(=C\c1ccccc1)c1ccccc1 10.1021/jm060850a
25210132 177656 0 None 9 2 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 403 7 2 3 4.2 COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 10.1021/jm800974d
CHEMBL445427 177656 0 None 9 2 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 403 7 2 3 4.2 COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 10.1021/jm800974d
1362 10210 22 None -39 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
9870523 10210 22 None -39 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
CHEMBL429392 10210 22 None -39 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
22718585 23278 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 6 1 3 3.4 CCC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL123634 23278 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 6 1 3 3.4 CCC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
44264950 211825 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 299 6 1 3 4.5 COc1cccc(Oc2ccc(NC(=O)CC(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7708 211825 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 299 6 1 3 4.5 COc1cccc(Oc2ccc(NC(=O)CC(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
137653199 165402 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 218 2 1 2 1.4 CC(=O)NCC1Cc2ccccc2N(C)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4092308 165402 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 218 2 1 2 1.4 CC(=O)NCC1Cc2ccccc2N(C)C1 10.1021/acs.jmedchem.8b00359
127041170 143467 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 584 15 2 4 6.1 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
CHEMBL3740377 143467 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 584 15 2 4 6.1 O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
127026425 144598 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759816 144598 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 295 4 1 3 3.6 COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 10.1016/j.ejmech.2015.12.047
25210133 196340 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.7 COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL514427 196340 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.7 COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
71540393 93188 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 226 2 2 1 2.7 CNC(=O)N/C=C/c1cccc2ccccc12 10.1016/j.bmcl.2012.11.069
CHEMBL2314254 93188 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 226 2 2 1 2.7 CNC(=O)N/C=C/c1cccc2ccccc12 10.1016/j.bmcl.2012.11.069
44424021 148869 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 690 21 4 8 6.2 COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL388141 148869 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 690 21 4 8 6.2 COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
145969866 171620 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 546 15 3 6 4.8 CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4218897 171620 0 None 2 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 546 15 3 6 4.8 CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1 10.1021/acs.jmedchem.8b00893
162644724 186173 0 None 57 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 321 5 1 4 3.0 COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4739898 186173 0 None 57 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 321 5 1 4 3.0 COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
44264965 212118 1 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 286 5 2 4 4.0 CCOC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7959 212118 1 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 286 5 2 4 4.0 CCOC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
44394556 131003 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 402 8 1 3 5.1 O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1 10.1016/j.bmcl.2004.07.055
CHEMBL363441 131003 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 402 8 1 3 5.1 O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1 10.1016/j.bmcl.2004.07.055
56671857 71227 0 None -10 2 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 384 13 1 4 4.3 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813324 71227 0 None -10 2 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 384 13 1 4 4.3 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1 10.1016/j.bmc.2011.06.063
22718619 23546 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 7 1 3 3.8 CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL124445 23546 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 7 1 3 3.8 CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
10089253 123863 0 None -12 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 350 9 1 3 4.5 CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL339265 123863 0 None -12 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 350 9 1 3 4.5 CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
145 6928 49 None -3 30 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
1832 6928 49 None -3 30 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
CHEMBL7257 6928 49 None -3 30 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
DB14010 6928 49 None -3 30 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/acs.jmedchem.5b00245
122178507 128102 0 None 13 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580915 128102 0 None 13 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
44317822 111653 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 315 8 1 3 3.7 CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC 10.1016/S0960-894X(97)00444-7
CHEMBL311106 111653 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 315 8 1 3 3.7 CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC 10.1016/S0960-894X(97)00444-7
10801655 28147 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 265 4 1 1 3.4 O=C(NCCC1Cc2cccc3cccc1c23)C1CC1 10.1021/jm000922c
CHEMBL131431 28147 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 265 4 1 1 3.4 O=C(NCCC1Cc2cccc3cccc1c23)C1CC1 10.1021/jm000922c
18360658 15662 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 518 13 2 5 5.7 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1097497 15662 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 518 13 2 5 5.7 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
86272990 128105 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 245 3 2 4 1.4 COc1ccc2[nH]cc(Cc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580918 128105 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 245 3 2 4 1.4 COc1ccc2[nH]cc(Cc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
44394478 73063 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 404 8 1 3 5.3 CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
CHEMBL184762 73063 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 404 8 1 3 5.3 CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
10465460 215085 2 None 1 2 Human 5.8 pKi = 5.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 202 3 2 1 1.8 CC(=O)NCCc1cc2ccccc2[nH]1 10.1021/jm001125h
CHEMBL99083 215085 2 None 1 2 Human 5.8 pKi = 5.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 202 3 2 1 1.8 CC(=O)NCCc1cc2ccccc2[nH]1 10.1021/jm001125h
1355 10211 5 None -70 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
9806449 10211 5 None -70 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
CHEMBL14453 10211 5 None -70 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
16105169 181456 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 345 3 1 3 3.3 CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 10.1016/j.bmc.2009.04.068
CHEMBL455909 181456 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 345 3 1 3 3.3 CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 10.1016/j.bmc.2009.04.068
22718596 124151 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 322 7 1 3 4.3 CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL339784 124151 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 322 7 1 3 4.3 CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
11078652 214697 0 None 16 2 Human 7.8 pKi = 7.8 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 351 7 1 3 4.3 CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL96778 214697 0 None 16 2 Human 7.8 pKi = 7.8 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 351 7 1 3 4.3 CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
10517621 214843 0 None 11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 290 3 1 2 3.3 CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 10.1021/jm980684+
CHEMBL9765 214843 0 None 11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 290 3 1 2 3.3 CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 10.1021/jm980684+
122178513 128111 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 288 5 2 5 3.1 CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 10.1021/acs.jmedchem.5b00245
CHEMBL3580926 128111 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 288 5 2 5 3.1 CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 10.1021/acs.jmedchem.5b00245
16743123 99851 0 None 4 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 270 5 1 2 3.0 CCC(=O)NCCCc1cn2c3c(cccc13)CCC2 10.1016/j.ejmech.2007.01.005
CHEMBL244263 99851 0 None 4 2 Human 7.8 pKi = 7.8 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 270 5 1 2 3.0 CCC(=O)NCCCc1cn2c3c(cccc13)CCC2 10.1016/j.ejmech.2007.01.005
10518621 104090 0 None 11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 304 4 1 2 3.7 CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 10.1021/jm980684+
CHEMBL269175 104090 0 None 11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 304 4 1 2 3.7 CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 10.1021/jm980684+
10640625 215075 0 None 46 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 336 7 1 3 3.8 CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1 10.1021/jm001125h
CHEMBL99002 215075 0 None 46 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 336 7 1 3 3.8 CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1 10.1021/jm001125h
16105169 181456 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 345 3 1 3 3.3 CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 10.1016/j.bmc.2009.04.068
CHEMBL455909 181456 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 345 3 1 3 3.3 CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 10.1016/j.bmc.2009.04.068
16105169 181456 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 345 3 1 3 3.3 CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 10.1016/j.bmc.2008.07.012
CHEMBL455909 181456 0 None -1 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 345 3 1 3 3.3 CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 10.1016/j.bmc.2008.07.012
44412082 146057 0 None -2 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 5 2 3 3.2 CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 10.1021/jm0512544
CHEMBL379096 146057 0 None -2 2 Human 5.8 pKi = 5.8 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 5 2 3 3.2 CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 10.1021/jm0512544
10022570 175326 0 None -13 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 378 10 1 3 5.1 CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL435586 175326 0 None -13 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 378 10 1 3 5.1 CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
11131123 177412 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 323 6 1 3 3.7 COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1 10.1021/jm0005252
CHEMBL445117 177412 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 323 6 1 3 3.7 COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1 10.1021/jm0005252
56664925 71224 0 None -53 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 498 17 2 6 3.8 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813321 71224 0 None -53 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 498 17 2 6 3.8 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
11485537 141990 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 370 5 1 4 4.0 CCC(=O)NCc1cc2c(OC)cccc2n1C(=O)c1ccc(Cl)cc1 10.1021/jm048956y
CHEMBL372243 141990 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 370 5 1 4 4.0 CCC(=O)NCc1cc2c(OC)cccc2n1C(=O)c1ccc(Cl)cc1 10.1021/jm048956y
9805364 43737 0 None -89 2 Human 6.7 pKi = 6.7 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 484 11 2 4 4.8 CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
CHEMBL14514 43737 0 None -89 2 Human 6.7 pKi = 6.7 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 484 11 2 4 4.8 CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
16743125 99078 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 296 5 1 2 3.4 O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1 10.1016/j.ejmech.2007.01.005
CHEMBL242786 99078 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 296 5 1 2 3.4 O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1 10.1016/j.ejmech.2007.01.005
44358217 34285 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 287 3 2 3 1.7 O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL136894 34285 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 287 3 2 3 1.7 O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
145971624 171392 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 517 15 2 5 6.0 CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4215980 171392 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 517 15 2 5 6.0 CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
10301190 15337 0 None -7 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 511 12 1 5 6.2 COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1 10.1016/j.bmc.2010.04.008
CHEMBL1094545 15337 0 None -7 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 511 12 1 5 6.2 COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1 10.1016/j.bmc.2010.04.008
12004056 181001 0 None -13 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 340 6 3 3 2.0 CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12 10.1016/j.ejmech.2019.111847
CHEMBL4548591 181001 0 None -13 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 340 6 3 3 2.0 CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12 10.1016/j.ejmech.2019.111847
81689735 128103 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 257 4 1 4 2.7 COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580916 128103 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 257 4 1 4 2.7 COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
118712372 120929 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 308 2 1 2 3.4 CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21 10.1016/j.ejmech.2014.09.038
CHEMBL3329390 120929 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 308 2 1 2 3.4 CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21 10.1016/j.ejmech.2014.09.038
16094577 90253 4 None 2 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 297 7 1 2 3.5 CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1 10.1021/jm060850a
CHEMBL220136 90253 4 None 2 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 297 7 1 2 3.5 CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1 10.1021/jm060850a
11418246 69177 0 None 4 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 403 6 1 3 5.8 O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1 10.1016/j.ejmech.2011.02.044
CHEMBL1779806 69177 0 None 4 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 403 6 1 3 5.8 O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1 10.1016/j.ejmech.2011.02.044
10946222 201520 0 None 43 2 Human 6.7 pKi = 6.7 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 291 5 1 5 1.8 COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL53622 201520 0 None 43 2 Human 6.7 pKi = 6.7 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 291 5 1 5 1.8 COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-] 10.1021/jm011053+
11208632 129683 1 None 2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 294 4 1 2 3.5 CCC(=O)NCCN1c2ccccc2CCc2ccccc21 10.1021/jm040768k
CHEMBL360600 129683 1 None 2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 294 4 1 2 3.5 CCC(=O)NCCN1c2ccccc2CCc2ccccc21 10.1021/jm040768k
11014883 214907 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 400 6 1 3 4.1 COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1 10.1021/jm001125h
CHEMBL98028 214907 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 400 6 1 3 4.1 COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1 10.1021/jm001125h
90666309 116163 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 403 7 2 3 4.2 COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1 10.1039/C1MD00149C
CHEMBL3219330 116163 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 403 7 2 3 4.2 COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1 10.1039/C1MD00149C
11581340 129119 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 363 8 1 2 4.6 CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL359921 129119 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 363 8 1 2 4.6 CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
20590652 136756 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 391 10 1 2 5.4 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL367604 136756 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 391 10 1 2 5.4 CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
20590654 136948 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 377 9 1 2 5.0 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL367797 136948 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 377 9 1 2 5.0 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
137637884 163025 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.3 CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4064813 163025 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 280 3 1 2 3.3 CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 10.1021/acs.jmedchem.8b00359
10424693 116420 1 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 297 4 1 2 3.1 COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 10.1039/C5MD00190K
CHEMBL322339 116420 1 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 297 4 1 2 3.1 COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 10.1039/C5MD00190K
127038129 143650 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 311 5 1 2 3.3 COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 10.1039/C5MD00190K
CHEMBL3742090 143650 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 311 5 1 2 3.3 COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 10.1039/C5MD00190K
145983175 173210 0 None 3 3 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 314 4 2 2 3.4 CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4277390 173210 0 None 3 3 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 314 4 2 2 3.4 CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145988801 173825 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 283 4 1 2 3.4 COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
CHEMBL4288925 173825 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 283 4 1 2 3.4 COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3 10.1016/j.ejmech.2017.10.025
44358231 33721 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 275 3 2 3 1.5 CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL136431 33721 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 275 3 2 3 1.5 CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
44264962 211629 0 None 46 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 283 5 1 3 4.0 C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7559 211629 0 None 46 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 283 5 1 3 4.0 C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
127025783 144516 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759160 144516 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 4 1 3 3.2 COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 10.1016/j.ejmech.2015.12.047
46885285 14939 0 None 186 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 265 8 1 3 2.6 CCCOc1ccc(OC)cc1CCCNC(C)=O 10.1016/j.bmcl.2010.02.084
CHEMBL1091894 14939 0 None 186 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 265 8 1 3 2.6 CCCOc1ccc(OC)cc1CCCNC(C)=O 10.1016/j.bmcl.2010.02.084
44429451 155991 0 None 15 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 352 6 1 3 3.4 CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL394406 155991 0 None 15 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 352 6 1 3 3.4 CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
168296374 199297 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
CHEMBL5209359 199297 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
10038243 123739 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 6 1 3 3.0 CCCC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL338659 123739 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 6 1 3 3.0 CCCC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
44272425 74101 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 300 5 2 3 3.1 CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 10.1016/j.bmcl.2003.12.052
CHEMBL18846 74101 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 300 5 2 3 3.1 CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 10.1016/j.bmcl.2003.12.052
44272406 75957 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 289 5 3 3 2.7 CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2 10.1016/j.bmcl.2003.12.052
CHEMBL19260 75957 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 289 5 3 3 2.7 CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2 10.1016/j.bmcl.2003.12.052
20355585 117642 6 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 280 4 2 2 2.8 COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl 10.1021/jm401343c
CHEMBL3260979 117642 6 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 280 4 2 2 2.8 COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl 10.1021/jm401343c
90666305 116159 0 None 125 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1 10.1039/C1MD00149C
CHEMBL3219326 116159 0 None 125 2 Human 8.7 pKi = 8.7 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.4 COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1 10.1039/C1MD00149C
44241666 202875 0 None 6 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 351 7 2 3 3.5 COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
CHEMBL560865 202875 0 None 6 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 351 7 2 3 3.5 COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
44429450 94139 0 None 6 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 338 5 1 3 3.0 CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL233310 94139 0 None 6 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 338 5 1 3 3.0 CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 10.1016/j.bmc.2007.04.013
22718561 24027 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 246 5 1 3 2.5 CCc1nc2cccc(CCCNC(C)=O)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL125665 24027 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 246 5 1 3 2.5 CCc1nc2cccc(CCCNC(C)=O)c2o1 10.1016/j.bmcl.2004.04.082
10015474 25332 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 5 1 3 2.8 Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL127596 25332 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 5 1 3 2.8 Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1 10.1016/j.bmcl.2004.04.082
9893513 37734 0 None -29 2 Human 8.6 pKi = 8.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 540 15 2 4 6.4 CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
CHEMBL13985 37734 0 None -29 2 Human 8.6 pKi = 8.6 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 540 15 2 4 6.4 CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm0255872
10925526 119111 0 None 26 2 Human 8.6 pKi = 8.6 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 329 6 1 3 4.2 COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL329299 119111 0 None 26 2 Human 8.6 pKi = 8.6 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 329 6 1 3 4.2 COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
44272438 77084 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 5 2 3 3.3 CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
CHEMBL19441 77084 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BBinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 302 5 2 3 3.3 CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 10.1016/j.bmcl.2003.12.052
16094584 90020 0 None 33 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 281 5 1 2 3.3 COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 10.1021/jm800974d
CHEMBL218708 90020 0 None 33 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 281 5 1 2 3.3 COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 10.1021/jm800974d
16094593 172823 0 None 91 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 281 5 1 2 3.3 COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1 10.1021/jm060850a
CHEMBL425644 172823 0 None 91 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 281 5 1 2 3.3 COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1 10.1021/jm060850a
25270146 37466 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 262 5 1 3 2.2 CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1 10.1016/j.bmcl.2003.09.030
CHEMBL139497 37466 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 262 5 1 3 2.2 CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1 10.1016/j.bmcl.2003.09.030
44358276 125750 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 289 4 2 3 1.9 CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL342393 125750 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 289 4 2 3 1.9 CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
15453093 93186 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 255 3 1 2 2.8 COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O 10.1016/j.bmcl.2012.11.069
CHEMBL2314252 93186 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 255 3 1 2 2.8 COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O 10.1016/j.bmcl.2012.11.069
16094588 143500 4 None 208 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 311 8 1 2 4.1 CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 10.1021/jm060850a
CHEMBL374075 143500 4 None 208 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 311 8 1 2 4.1 CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 10.1021/jm060850a
44429445 94307 0 None 6 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 5 1 3 2.6 CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL233516 94307 0 None 6 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 274 5 1 3 2.6 CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 10.1016/j.bmc.2007.04.013
10400294 25321 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 258 5 1 3 2.6 Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL127570 25321 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 258 5 1 3 2.6 Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
11536239 83477 1 None -2 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 2 2 2.6 COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1 10.1021/jm0512544
CHEMBL206472 83477 1 None -2 2 Human 8.6 pKi = 8.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 260 4 2 2 2.6 COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1 10.1021/jm0512544
49865321 22670 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 251 7 1 3 2.4 CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223195 22670 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 251 7 1 3 2.4 CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
11046748 214716 0 None 19 2 Human 8.6 pKi = 8.6 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 365 8 1 4 3.9 C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm0005252
CHEMBL96916 214716 0 None 19 2 Human 8.6 pKi = 8.6 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 365 8 1 4 3.9 C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 10.1021/jm0005252
20642483 37425 0 None -2 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 272 3 1 3 1.7 O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 10.1016/j.bmcl.2003.09.030
CHEMBL139439 37425 0 None -2 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 272 3 1 3 1.7 O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 10.1016/j.bmcl.2003.09.030
10332159 23566 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 246 5 1 3 2.6 CCC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL124577 23566 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 246 5 1 3 2.6 CCC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
44394438 73738 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 375 9 1 2 5.6 CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL186736 73738 0 None -1 2 Human 8.6 pKi = 8.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 375 9 1 2 5.6 CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
11630146 84860 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 246 4 2 2 2.4 COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1 10.1021/jm0512544
CHEMBL210147 84860 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 246 4 2 2 2.4 COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1 10.1021/jm0512544
23642306 165852 1 None -2 3 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 6 2 3 2.5 CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
CHEMBL4097233 165852 1 None -2 3 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 6 2 3 2.5 CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
44389812 69776 0 None -19 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 365 10 1 2 4.9 CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL178678 69776 0 None -19 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 365 10 1 2 4.9 CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
44424024 91948 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 522 16 2 6 5.6 COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL225301 91948 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 522 16 2 6 5.6 COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
49865269 22650 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 249 6 1 3 2.0 COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223129 22650 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 249 6 1 3 2.0 COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
16094591 90098 4 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 283 6 1 2 3.2 COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1 10.1021/jm060850a
CHEMBL219127 90098 4 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 283 6 1 2 3.2 COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1 10.1021/jm060850a
56661499 71198 0 None -102 2 Human 5.7 pKi = 5.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 456 14 2 6 2.7 CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813174 71198 0 None -102 2 Human 5.7 pKi = 5.7 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 456 14 2 6 2.7 CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
90666302 116156 0 None 11 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.4 COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1 10.1039/C1MD00149C
CHEMBL3219323 116156 0 None 11 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 2 3 3.4 COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1 10.1039/C1MD00149C
127038130 143401 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 347 8 1 2 4.5 CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3739824 143401 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 347 8 1 2 4.5 CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 10.1039/C5MD00190K
85880795 117645 0 None -12 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 319 9 1 3 4.0 CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 10.1021/jm401343c
CHEMBL3260984 117645 0 None -12 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 319 9 1 3 4.0 CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 10.1021/jm401343c
10714573 105269 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 376 6 1 3 4.7 CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL276005 105269 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 376 6 1 3 4.7 CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1 10.1021/jm980684+
22718571 23610 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 8 1 3 3.6 CCCC(=O)NCCCc1cccc2nc(CCC)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL124782 23610 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 8 1 3 3.6 CCCC(=O)NCCCc1cccc2nc(CCC)oc12 10.1016/j.bmcl.2004.04.082
44349100 121589 0 None -34 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 376 10 1 3 4.9 O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 10.1016/j.bmcl.2004.04.082
CHEMBL334079 121589 0 None -34 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 376 10 1 3 4.9 O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 10.1016/j.bmcl.2004.04.082
137640743 163824 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 COc1ccc2ccc(CCNC(C)=O)cc2n1 10.1016/j.ejmech.2016.12.013
CHEMBL4073867 163824 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 COc1ccc2ccc(CCNC(C)=O)cc2n1 10.1016/j.ejmech.2016.12.013
44349100 121589 0 None -34 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 10 1 3 4.9 O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 10.1021/jm401343c
CHEMBL334079 121589 0 None -34 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 10 1 3 4.9 O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 10.1021/jm401343c
44357899 125459 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 4 1 3 2.1 CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL341705 125459 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 4 1 3 2.1 CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
86272984 128110 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 288 4 2 4 3.0 CCn1c(Cc2c[nH]c3ccc(OC)cc23)n[nH]c1=S 10.1021/acs.jmedchem.5b00245
CHEMBL3580924 128110 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 288 4 2 4 3.0 CCn1c(Cc2c[nH]c3ccc(OC)cc23)n[nH]c1=S 10.1021/acs.jmedchem.5b00245
10610443 215086 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 246 5 2 2 2.2 CCC(=O)NCCc1cc2c(OC)cccc2[nH]1 10.1021/jm001125h
CHEMBL99084 215086 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 246 5 2 2 2.2 CCC(=O)NCCc1cc2c(OC)cccc2[nH]1 10.1021/jm001125h
45268309 203050 0 None 4 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 303 7 2 3 2.3 CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1016/j.bmc.2009.04.068
CHEMBL561928 203050 0 None 4 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 303 7 2 3 2.3 CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1016/j.bmc.2009.04.068
10567427 11012 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 316 4 1 2 3.7 O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1 10.1021/jm980684+
CHEMBL10043 11012 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 316 4 1 2 3.7 O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1 10.1021/jm980684+
10853021 104913 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 318 3 1 2 3.9 CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 10.1021/jm980684+
CHEMBL273623 104913 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 318 3 1 2 3.9 CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 10.1021/jm980684+
127025786 144627 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 312 5 2 3 3.5 CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 10.1016/j.ejmech.2015.12.047
CHEMBL3760044 144627 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 312 5 2 3 3.5 CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 10.1016/j.ejmech.2015.12.047
139451784 192174 0 None -6 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 317 7 1 5 2.4 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 10.1021/acs.jmedchem.0c00627
CHEMBL4860729 192174 0 None -6 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 317 7 1 5 2.4 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 10.1021/acs.jmedchem.0c00627
12985490 187999 0 None 12 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL476132 187999 0 None 12 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 349 6 2 3 3.7 COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
10390684 18102 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 359 9 1 3 3.0 CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL1179488 18102 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 359 9 1 3 3.0 CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL78338 18102 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 359 9 1 3 3.0 CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
10069719 200177 4 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 403 5 2 4 2.4 COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL52559 200177 4 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 403 5 2 4 2.4 COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-] 10.1021/jm011053+
162673916 189813 0 None 2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 327 6 1 5 2.9 COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
CHEMBL4793947 189813 0 None 2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 327 6 1 5 2.9 COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
46885229 14478 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 375 9 1 3 4.6 COc1ccc(OCc2ccccc2)c(CCCNC(=O)c2ccccc2)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1088826 14478 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 375 9 1 3 4.6 COc1ccc(OCc2ccccc2)c(CCCNC(=O)c2ccccc2)c1 10.1016/j.bmcl.2010.02.084
16743464 99101 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 310 3 1 2 3.9 CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 10.1016/j.ejmech.2007.01.005
CHEMBL243002 99101 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 310 3 1 2 3.9 CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 10.1016/j.ejmech.2007.01.005
44412141 83518 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 312 4 2 3 3.2 Cn1cc(C2(CNC(=O)C3CCC3)CCC2)c2cc(O)ccc21 10.1021/jm0512544
CHEMBL206686 83518 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 312 4 2 3 3.2 Cn1cc(C2(CNC(=O)C3CCC3)CCC2)c2cc(O)ccc21 10.1021/jm0512544
49865266 22647 2 None 1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 225 5 1 3 1.9 COc1ccc(SCCNC(C)=O)cc1 10.1016/j.bmc.2010.06.100
CHEMBL1223126 22647 2 None 1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 225 5 1 3 1.9 COc1ccc(SCCNC(C)=O)cc1 10.1016/j.bmc.2010.06.100
127025782 144509 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 297 4 1 3 3.9 COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 10.1016/j.ejmech.2015.12.047
CHEMBL3759054 144509 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 297 4 1 3 3.9 COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 10.1016/j.ejmech.2015.12.047
25210134 196403 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 315 6 2 3 2.5 COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL514904 196403 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 315 6 2 3 2.5 COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 10.1021/jm800974d
53231367 69179 0 None 117 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 425 8 1 3 6.0 O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779808 69179 0 None 117 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 425 8 1 3 6.0 O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
11045144 215061 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 310 4 2 2 3.0 CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br 10.1021/jm001125h
CHEMBL98956 215061 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 310 4 2 2 3.0 CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br 10.1021/jm001125h
56662799 71230 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 526 15 2 6 2.9 COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813327 71230 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 526 15 2 6 2.9 COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1 10.1016/j.bmc.2011.06.063
9888609 15664 0 None -46 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrs
ChEMBL 424 7 2 2 5.0 CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1039/C5MD00190K
CHEMBL1097525 15664 0 None -46 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO-K1 cells after 2 hrs
ChEMBL 424 7 2 2 5.0 CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1039/C5MD00190K
9888609 15664 0 None -46 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 424 7 2 2 5.0 CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm401343c
CHEMBL1097525 15664 0 None -46 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 424 7 2 2 5.0 CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1021/jm401343c
25210134 196403 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 315 6 2 3 2.5 COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL514904 196403 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 315 6 2 3 2.5 COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 10.1021/jm800974d
162668689 189537 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 285 5 1 4 2.2 COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4790145 189537 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 285 5 1 4 2.2 COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
44264857 211888 2 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 286 5 2 3 3.6 CCNC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7772 211888 2 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 286 5 2 3 3.6 CCNC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
137646628 164357 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 275 4 2 3 1.9 CNC(=S)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
CHEMBL4080608 164357 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 275 4 2 3 1.9 CNC(=S)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
11602301 83476 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 326 5 1 3 3.5 COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C 10.1021/jm0512544
CHEMBL206471 83476 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 326 5 1 3 3.5 COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C 10.1021/jm0512544
44349258 23689 1 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 261 5 2 3 2.4 CCNC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL125226 23689 1 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 261 5 2 3 2.4 CCNC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
137660180 165901 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 270 5 1 3 2.3 COc1cnc2cccc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2016.12.013
CHEMBL4097817 165901 0 None 4 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 270 5 1 3 2.3 COc1cnc2cccc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2016.12.013
CHEMBL3109560 217867 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins
ChEMBL None None None COc1ccc(/C=C/C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1 10.1021/ml4004155
46885283 15027 0 None 48 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 237 6 1 3 1.8 COc1ccc(OC)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1092400 15027 0 None 48 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 237 6 1 3 1.8 COc1ccc(OC)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
25210000 196273 0 None 11 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 408 7 2 5 3.3 COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL513933 196273 0 None 11 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 408 7 2 5 3.3 COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
49865323 22672 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 267 7 1 3 3.1 CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223197 22672 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 267 7 1 3 3.1 CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
25210000 196273 0 None 11 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 408 7 2 5 3.3 COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL513933 196273 0 None 11 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 408 7 2 5 3.3 COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
9925874 169009 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1cccc(Oc2cccc(OC)c2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL416328 169009 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 285 6 1 3 4.2 CCCC(=O)Nc1cccc(Oc2cccc(OC)c2)c1 10.1016/j.bmcl.2003.11.030
145975938 170678 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 519 14 3 6 5.4 CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4207166 170678 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 519 14 3 6 5.4 CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1 10.1021/acs.jmedchem.8b00893
162674710 190113 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 270 3 1 4 2.4 COc1ccc2c(c1)C(/C=C/c1n[nH]c(=O)o1)=CCC2 10.1016/j.ejmech.2020.112090
CHEMBL4797429 190113 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 270 3 1 4 2.4 COc1ccc2c(c1)C(/C=C/c1n[nH]c(=O)o1)=CCC2 10.1016/j.ejmech.2020.112090
46935149 22623 2 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SC(C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223051 22623 2 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SC(C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
49865378 22707 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SC[C@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223281 22707 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(SC[C@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
22718661 23611 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 7 1 3 3.2 CCCc1nc2cccc(CCCNC(=O)CC)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL124783 23611 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 7 1 3 3.2 CCCc1nc2cccc(CCCNC(=O)CC)c2o1 10.1016/j.bmcl.2004.04.082
24749950 10688 8 None 588 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 284 6 1 3 3.0 COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C 10.1021/jm700957j
7923 10688 8 None 588 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 284 6 1 3 3.0 COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C 10.1021/jm700957j
CHEMBL394676 10688 8 None 588 2 Human 7.6 pKi = 7.6 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 284 6 1 3 3.0 COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C 10.1021/jm700957j
46885288 15101 0 None 95 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 343 9 1 4 3.4 COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1 10.1016/j.bmcl.2010.02.084
CHEMBL1092839 15101 0 None 95 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 343 9 1 4 3.4 COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1 10.1016/j.bmcl.2010.02.084
10903368 214883 0 None 4 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 322 6 1 3 3.7 CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1 10.1021/jm001125h
CHEMBL97885 214883 0 None 4 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 322 6 1 3 3.7 CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1 10.1021/jm001125h
164946945 197008 1 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5174929 197008 1 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 427 9 1 7 3.3 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
11529521 83534 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 298 5 2 2 3.1 COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1 10.1021/jm0512544
CHEMBL206790 83534 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 298 5 2 2 3.1 COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1 10.1021/jm0512544
162645859 186486 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 315 3 1 5 1.5 CCNC(=O)N1CCN(c2ncnc3ccc(OC)cc23)CC1 10.1016/j.ejmech.2020.112078
CHEMBL4743884 186486 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 315 3 1 5 1.5 CCNC(=O)N1CCN(c2ncnc3ccc(OC)cc23)CC1 10.1016/j.ejmech.2020.112078
10657206 126467 2 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 2.2 CCC(=O)NCc1cc2c(OC)cccc2[nH]1 10.1021/jm001125h
CHEMBL34728 126467 2 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 2.2 CCC(=O)NCc1cc2c(OC)cccc2[nH]1 10.1021/jm001125h
11326232 134202 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 372 6 1 5 2.9 CCC(=O)NCc1cc2c(OC)cccc2n1S(=O)(=O)c1ccccc1 10.1021/jm048956y
CHEMBL366004 134202 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 372 6 1 5 2.9 CCC(=O)NCc1cc2c(OC)cccc2n1S(=O)(=O)c1ccccc1 10.1021/jm048956y
10091075 24053 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 378 11 1 3 5.2 CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL125705 24053 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 378 11 1 3 5.2 CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
22718654 120109 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 7 1 3 3.5 CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL331636 120109 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 7 1 3 3.5 CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 10.1016/j.bmcl.2004.04.082
85880795 117645 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 319 9 1 3 4.0 CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 10.1021/jm401343c
CHEMBL3260984 117645 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 319 9 1 3 4.0 CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 10.1021/jm401343c
11065731 108658 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 277 5 2 4 1.8 COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1 10.1021/jm011053+
CHEMBL300729 108658 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 277 5 2 4 1.8 COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1 10.1021/jm011053+
145976375 170576 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 525 15 2 6 5.7 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4206000 170576 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 525 15 2 6 5.7 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 10.1021/acs.jmedchem.8b00893
145990308 173811 0 None 13 3 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 328 5 2 2 3.8 CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4288690 173811 0 None 13 3 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 328 5 2 2 3.8 CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
145986700 173998 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 328 4 2 2 3.5 CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4292109 173998 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 328 4 2 2 3.5 CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
139451767 191783 0 None -2 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 263 5 1 5 1.2 COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
CHEMBL4854625 191783 0 None -2 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 263 5 1 5 1.2 COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
11776674 123427 1 None 1 2 Human 8.5 pKi = 8.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 246 4 1 3 1.9 COc1ccc2c(c1)c(CCNC(C)=O)cn2C 10.1021/jm011053+
CHEMBL33700 123427 1 None 1 2 Human 8.5 pKi = 8.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 246 4 1 3 1.9 COc1ccc2c(c1)c(CCNC(C)=O)cn2C 10.1021/jm011053+
139451799 192618 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 279 5 1 5 1.9 COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
CHEMBL4867553 192618 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 279 5 1 5 1.9 COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 10.1021/acs.jmedchem.0c00627
10938056 113835 0 None 2 2 Human 8.5 pKi = 8.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 393 11 1 3 5.7 CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL315653 113835 0 None 2 2 Human 8.5 pKi = 8.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 393 11 1 3 5.7 CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
11637615 84022 0 None 2 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 272 4 2 2 2.7 COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1 10.1021/jm0512544
CHEMBL207960 84022 0 None 2 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 272 4 2 2 2.7 COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1 10.1021/jm0512544
71508234 7492 0 None 38 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 10.1016/j.bmc.2012.10.060
7924 7492 0 None 38 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 10.1016/j.bmc.2012.10.060
CHEMBL2326202 7492 0 None 38 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
ChEMBL 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 10.1016/j.bmc.2012.10.060
10427851 188612 0 None 407 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 348 6 2 3 3.7 COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL477834 188612 0 None 407 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 348 6 2 3 3.7 COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
122193492 130720 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 261 4 1 4 1.5 COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2015.09.003
CHEMBL3628489 130720 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry
ChEMBL 261 4 1 4 1.5 COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2015.09.003
189748 23588 9 None 60 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 262 5 2 3 1.9 COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC 10.1021/jm401343c
CHEMBL124699 23588 9 None 60 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
ChEMBL 262 5 2 3 1.9 COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC 10.1021/jm401343c
11088627 214324 0 None 8 2 Human 8.5 pKi = 8.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 324 6 1 4 3.1 COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL94745 214324 0 None 8 2 Human 8.5 pKi = 8.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 324 6 1 4 3.1 COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
44349108 23636 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 246 6 1 3 2.7 CCCC(=O)NCCCc1cccc2ncoc12 10.1016/j.bmcl.2004.04.082
CHEMBL124914 23636 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 246 6 1 3 2.7 CCCC(=O)NCCCc1cccc2ncoc12 10.1016/j.bmcl.2004.04.082
10711649 214563 0 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 332 5 1 2 4.3 CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 10.1021/jm980684+
CHEMBL9605 214563 0 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 332 5 1 2 4.3 CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 10.1021/jm980684+
90666306 116160 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 7 2 3 3.8 CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 10.1039/C1MD00149C
CHEMBL3219327 116160 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 7 2 3 3.8 CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 10.1039/C1MD00149C
24750194 96723 0 None 87 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 324 7 1 3 3.8 COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm700957j
CHEMBL238049 96723 0 None 87 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 324 7 1 3 3.8 COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1 10.1021/jm700957j
49865319 22668 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 251 7 1 3 2.4 CCCC(=O)NCC(C)Oc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223193 22668 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 251 7 1 3 2.4 CCCC(=O)NCC(C)Oc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
137644121 164928 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 291 4 1 1 4.0 CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1 10.1021/acs.jmedchem.8b00359
CHEMBL4087265 164928 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 291 4 1 1 4.0 CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1 10.1021/acs.jmedchem.8b00359
86273227 128095 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 242 4 2 2 1.5 C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580907 128095 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 242 4 2 2 1.5 C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
10800029 123488 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 239 3 1 1 3.0 CC(=O)NCCC1Cc2cccc3cccc1c23 10.1021/jm000922c
CHEMBL337295 123488 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 239 3 1 1 3.0 CC(=O)NCCC1Cc2cccc3cccc1c23 10.1021/jm000922c
24750190 96660 1 None 32 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 254 5 1 2 3.0 CC(=O)NCCN(c1ccccc1)c1ccccc1 10.1021/jm700957j
CHEMBL237840 96660 1 None 32 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 254 5 1 2 3.0 CC(=O)NCCN(c1ccccc1)c1ccccc1 10.1021/jm700957j
139451780 192723 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 303 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 10.1021/acs.jmedchem.0c00627
CHEMBL4869463 192723 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 303 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 10.1021/acs.jmedchem.0c00627
44389845 71606 0 None -15 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 377 10 1 2 4.9 O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 10.1016/j.bmcl.2005.01.015
CHEMBL181974 71606 0 None -15 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 377 10 1 2 4.9 O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 10.1016/j.bmcl.2005.01.015
44389813 138152 0 None -15 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 379 11 1 2 5.3 CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL368886 138152 0 None -15 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 379 11 1 2 5.3 CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
54582195 67536 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 329 5 1 5 1.9 COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760955 67536 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 329 5 1 5 1.9 COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
25209999 182297 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 441 6 2 3 4.2 COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL457807 182297 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 441 6 2 3 4.2 COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
11173131 130876 0 None 7 2 Human 7.5 pKi = 7.5 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 265 2 1 1 3.1 CC(=O)NCC1Cc2ccccc2Cc2ccccc21 10.1021/jm040768k
CHEMBL363321 130876 0 None 7 2 Human 7.5 pKi = 7.5 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 265 2 1 1 3.1 CC(=O)NCC1Cc2ccccc2Cc2ccccc21 10.1021/jm040768k
25209999 182297 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 441 6 2 3 4.2 COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
CHEMBL457807 182297 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 441 6 2 3 4.2 COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 10.1021/jm800974d
162667374 189334 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 357 10 1 5 4.1 CCCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O 10.1016/j.ejmech.2020.112090
CHEMBL4787595 189334 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 357 10 1 5 4.1 CCCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O 10.1016/j.ejmech.2020.112090
44429452 94140 0 None 4 2 Human 5.5 pKi = 5.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 308 5 2 2 3.5 COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.04.013
CHEMBL233311 94140 0 None 4 2 Human 5.5 pKi = 5.5 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 308 5 2 2 3.5 COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.04.013
49865375 22704 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OC[C@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223278 22704 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OC[C@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
10737123 104155 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 358 4 1 2 4.7 O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1 10.1021/jm980684+
CHEMBL269670 104155 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 358 4 1 2 4.7 O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1 10.1021/jm980684+
56662798 71229 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 554 21 2 6 5.4 COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813326 71229 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 554 21 2 6 5.4 COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 10.1016/j.bmc.2011.06.063
11794657 215100 0 None 23 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 388 5 1 3 4.7 COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL9917 215100 0 None 23 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 388 5 1 3 4.7 COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL3109561 217868 0 None -6 2 Human 6.5 pKi = 6.5 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins
ChEMBL None None None COc1ccc(C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1 10.1021/ml4004155
11680808 83854 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 5 2 2 3.1 CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 10.1021/jm0512544
CHEMBL207420 83854 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 5 2 2 3.1 CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 10.1021/jm0512544
145978811 170639 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 531 16 2 5 6.4 CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4206642 170639 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 531 16 2 5 6.4 CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
162668486 189353 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 377 8 1 5 3.7 COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
CHEMBL4787877 189353 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 377 8 1 5 3.7 COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
10595585 105322 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 374 5 1 3 4.3 COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1 10.1021/jm980684+
CHEMBL276490 105322 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 374 5 1 3 4.3 COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1 10.1021/jm980684+
162646341 186279 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 312 3 0 5 1.7 COc1ccc2ncnc(N3CCN(C(=O)C4CC4)CC3)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4741114 186279 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 312 3 0 5 1.7 COc1ccc2ncnc(N3CCN(C(=O)C4CC4)CC3)c2c1 10.1016/j.ejmech.2020.112078
9817692 212440 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 297 6 1 3 3.7 CCCC(=O)Nc1ccc(C(=O)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL8200 212440 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 297 6 1 3 3.7 CCCC(=O)Nc1ccc(C(=O)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
44394394 129488 0 None -2 2 Human 7.5 pKi = 7.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 387 9 1 2 5.6 O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 10.1016/j.bmcl.2004.07.055
CHEMBL360428 129488 0 None -2 2 Human 7.5 pKi = 7.5 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 387 9 1 2 5.6 O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 10.1016/j.bmcl.2004.07.055
11515177 147838 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 314 5 1 3 3.4 COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C 10.1021/jm0512544
CHEMBL382439 147838 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 314 5 1 3 3.4 COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C 10.1021/jm0512544
145963877 171035 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 503 14 2 5 5.7 CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4211530 171035 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 503 14 2 5 5.7 CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
44587356 200163 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 423 8 3 5 2.8 COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1016/j.bmc.2008.07.012
CHEMBL525374 200163 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 423 8 3 5 2.8 COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1016/j.bmc.2008.07.012
90666308 116162 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 7 2 3 3.8 COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1 10.1039/C1MD00149C
CHEMBL3219329 116162 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 7 2 3 3.8 COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1 10.1039/C1MD00149C
10520058 104914 0 None 8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 324 3 1 2 4.0 CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2 10.1021/jm980684+
CHEMBL273624 104914 0 None 8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 324 3 1 2 4.0 CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2 10.1021/jm980684+
145968467 171568 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 400 13 2 5 4.0 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4218247 171568 0 None -5 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 400 13 2 5 4.0 CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1 10.1021/acs.jmedchem.8b00893
13250272 22646 17 None 11 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 195 4 1 2 1.9 CC(=O)NCCSc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223125 22646 17 None 11 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 195 4 1 2 1.9 CC(=O)NCCSc1ccccc1 10.1016/j.bmc.2010.06.100
10950593 118298 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 459 6 1 3 5.7 COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL327864 118298 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 459 6 1 3 5.7 COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
49865373 22702 2 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OCC(C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223276 22702 2 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OCC(C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
9860296 35990 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 272 3 1 3 1.7 O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 10.1016/j.bmcl.2003.09.030
CHEMBL138228 35990 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 272 3 1 3 1.7 O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 10.1016/j.bmcl.2003.09.030
22718579 23294 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 5 1 3 3.0 CC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL123690 23294 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 5 1 3 3.0 CC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
22718521 23425 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 6 1 3 2.8 CCCc1nc2cccc(CCCNC(C)=O)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL124216 23425 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 260 6 1 3 2.8 CCCc1nc2cccc(CCCNC(C)=O)c2o1 10.1016/j.bmcl.2004.04.082
21581653 144821 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 2 3 1.3 COc1cc2c(CCNC(C)=O)c[nH]c2cn1 10.1016/j.ejmech.2016.01.008
CHEMBL3765249 144821 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 233 4 2 3 1.3 COc1cc2c(CCNC(C)=O)c[nH]c2cn1 10.1016/j.ejmech.2016.01.008
10638747 215146 0 None 11 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 310 4 2 2 2.6 COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1 10.1021/jm001125h
CHEMBL99512 215146 0 None 11 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 310 4 2 2 2.6 COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1 10.1021/jm001125h
1362 10210 22 None -39 2 Human 6.5 pKi = 6.5 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
9870523 10210 22 None -39 2 Human 6.5 pKi = 6.5 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
CHEMBL429392 10210 22 None -39 2 Human 6.5 pKi = 6.5 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
10736247 215142 0 None 5 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 344 4 1 2 4.3 O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1 10.1021/jm980684+
CHEMBL9950 215142 0 None 5 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 344 4 1 2 4.3 O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1 10.1021/jm980684+
44349329 25320 1 None 13 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 289 7 2 3 3.0 CCCc1nc2cccc(CCCNC(=O)NCC)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL127565 25320 1 None 13 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 289 7 2 3 3.0 CCCc1nc2cccc(CCCNC(=O)NCC)c2o1 10.1016/j.bmcl.2004.04.082
44587357 194929 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 393 7 3 4 2.8 COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.07.012
CHEMBL498494 194929 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 393 7 3 4 2.8 COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.07.012
10709646 214612 0 None 10 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 304 3 1 2 3.5 CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 10.1021/jm980684+
CHEMBL9634 214612 0 None 10 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 304 3 1 2 3.5 CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 10.1021/jm980684+
56671858 71228 0 None 20 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 498 17 2 6 3.8 COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813325 71228 0 None 20 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 498 17 2 6 3.8 COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 10.1016/j.bmc.2011.06.063
10948786 214579 0 None 18 2 Human 7.4 pKi = 7.4 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 375 7 1 4 4.6 COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1 10.1021/jm0005252
CHEMBL96173 214579 0 None 18 2 Human 7.4 pKi = 7.4 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 375 7 1 4 4.6 COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1 10.1021/jm0005252
11624018 147666 0 None -5 2 Human 5.4 pKi = 5.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 326 5 1 3 3.5 COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C 10.1021/jm0512544
CHEMBL382050 147666 0 None -5 2 Human 5.4 pKi = 5.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 326 5 1 3 3.5 COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C 10.1021/jm0512544
44349305 177915 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 320 6 1 3 4.0 O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1 10.1016/j.bmcl.2004.04.082
CHEMBL445840 177915 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 320 6 1 3 4.0 O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1 10.1016/j.bmcl.2004.04.082
11393103 132582 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 322 5 1 3 3.8 CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21 10.1021/jm040768k
CHEMBL364806 132582 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 322 5 1 3 3.8 CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21 10.1021/jm040768k
118712360 120928 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 330 4 0 4 2.6 CCN(CC)C(=O)CN1CCCC2Cc3cc4c(cc3C21)OCO4 10.1016/j.ejmech.2014.09.038
CHEMBL3329377 120928 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting
ChEMBL 330 4 0 4 2.6 CCN(CC)C(=O)CN1CCCC2Cc3cc4c(cc3C21)OCO4 10.1016/j.ejmech.2014.09.038
12436514 22699 6 None 3 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)NC(C)COc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223273 22699 6 None 3 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)NC(C)COc1ccccc1 10.1016/j.bmc.2010.06.100
44264983 212177 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 296 5 2 3 4.1 CCCC(=O)Nc1ccc(Nc2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL8004 212177 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 296 5 2 3 4.1 CCCC(=O)Nc1ccc(Nc2cccc3c2CCO3)cc1 10.1016/j.bmcl.2003.11.030
11623375 145470 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 5 1 3 2.7 CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 10.1021/jm0512544
CHEMBL377871 145470 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 5 1 3 2.7 CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 10.1021/jm0512544
10454621 108657 4 None 47 2 Human 7.4 pKi = 7.4 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 417 5 1 5 2.4 COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL300728 108657 4 None 47 2 Human 7.4 pKi = 7.4 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 417 5 1 5 2.4 COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-] 10.1021/jm011053+
44358035 36737 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 260 3 1 3 1.7 CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL138848 36737 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 260 3 1 3 1.7 CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
11392720 73825 0 None 4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 309 4 1 2 3.5 COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2 10.1021/jm040768k
CHEMBL187160 73825 0 None 4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 309 4 1 2 3.5 COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2 10.1021/jm040768k
168288029 198400 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 471 9 1 9 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5195595 198400 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 471 9 1 9 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
49865265 22645 2 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 225 5 1 3 1.9 COc1cccc(SCCNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223124 22645 2 None 1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 225 5 1 3 1.9 COc1cccc(SCCNC(C)=O)c1 10.1016/j.bmc.2010.06.100
162644334 188598 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 341 6 1 5 3.3 COc1ccc2[nH]cc(CCc3nn(CC4CCCC4)c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
CHEMBL4778192 188598 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 341 6 1 5 3.3 COc1ccc2[nH]cc(CCc3nn(CC4CCCC4)c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
162643514 188466 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 271 5 1 4 1.7 COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4776540 188466 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 271 5 1 4 1.7 COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1 10.1016/j.ejmech.2020.112078
145965883 170861 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 307 11 2 4 2.2 CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4209446 170861 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 307 11 2 4 2.2 CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1 10.1021/acs.jmedchem.8b00893
122178509 128106 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580919 128106 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1021/acs.jmedchem.5b00245
137655435 165589 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 COc1cnc2cccc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2016.12.013
CHEMBL4094436 165589 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 244 4 1 3 1.9 COc1cnc2cccc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2016.12.013
122178509 128106 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
CHEMBL3580919 128106 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 259 4 2 4 1.6 COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
9796251 124888 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
CHEMBL340745 124888 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
9839199 28135 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
CHEMBL131424 28135 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 297 5 1 2 3.8 CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 10.1021/jm000922c
9859913 212309 0 None 20 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 257 4 1 3 3.4 COc1cccc(Oc2ccc(NC(C)=O)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL8094 212309 0 None 20 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 257 4 1 3 3.4 COc1cccc(Oc2ccc(NC(C)=O)cc2)c1 10.1016/j.bmcl.2003.11.030
44264707 103946 1 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 256 4 2 3 3.4 COc1cccc(Nc2ccc(NC(C)=O)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL268165 103946 1 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 256 4 2 3 3.4 COc1cccc(Nc2ccc(NC(C)=O)cc2)c1 10.1016/j.bmcl.2003.11.030
127025787 144510 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 298 4 2 3 3.4 CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
CHEMBL3759080 144510 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 298 4 2 3 3.4 CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
46888522 15417 0 None -11 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 513 12 1 5 6.2 COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 10.1016/j.bmc.2010.04.008
CHEMBL1095197 15417 0 None -11 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 513 12 1 5 6.2 COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 10.1016/j.bmc.2010.04.008
22718532 23555 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 218 4 1 3 1.9 CC(=O)NCCCc1cccc2ncoc12 10.1016/j.bmcl.2004.04.082
CHEMBL124488 23555 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 218 4 1 3 1.9 CC(=O)NCCCc1cccc2ncoc12 10.1016/j.bmcl.2004.04.082
46935150 22651 0 None -6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 249 6 1 3 2.0 COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223130 22651 0 None -6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 249 6 1 3 2.0 COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
11463056 69176 0 None 51 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 1 3 5.4 CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779805 69176 0 None 51 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 377 6 1 3 5.4 CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
11638009 172542 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 5 1 3 3.1 CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 10.1021/jm0512544
CHEMBL424693 172542 0 None 7 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 5 1 3 3.1 CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 10.1021/jm0512544
22718602 103319 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 6 1 3 3.1 CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL262890 103319 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 274 6 1 3 3.1 CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 10.1016/j.bmcl.2004.04.082
139451761 191376 0 None -4 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
CHEMBL4848885 191376 0 None -4 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 291 7 1 5 2.0 CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O 10.1021/acs.jmedchem.0c00627
53310838 70565 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 321 4 1 4 2.8 CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3 10.1021/jm200385u
CHEMBL1802021 70565 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 321 4 1 4 2.8 CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3 10.1021/jm200385u
168296374 199297 0 None 2 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
CHEMBL5209359 199297 0 None 2 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
ChEMBL 505 9 1 8 4.5 CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 10.1021/acs.jmedchem.2c00717
145972981 171274 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 513 13 3 4 6.2 CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 10.1021/acs.jmedchem.8b00893
CHEMBL4214478 171274 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 513 13 3 4 6.2 CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 10.1021/acs.jmedchem.8b00893
44358238 126150 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 261 2 2 3 1.1 CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL344449 126150 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 261 2 2 3 1.1 CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
49865204 22622 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(O[C@@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223050 22622 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(O[C@@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
44348996 23979 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 272 6 1 3 2.8 CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL125642 23979 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 272 6 1 3 2.8 CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
44264942 212223 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 313 5 1 4 4.0 CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL8032 212223 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 313 5 1 4 4.0 CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1 10.1016/j.bmcl.2003.11.030
44264844 211641 0 None 2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 296 5 1 3 3.8 COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7567 211641 0 None 2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 296 5 1 3 3.8 COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1 10.1016/j.bmcl.2003.11.030
44424023 151592 0 None 14 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 346 9 2 4 3.2 CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1016/j.bmc.2007.03.080
CHEMBL390944 151592 0 None 14 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 346 9 2 4 3.2 CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1016/j.bmc.2007.03.080
53231465 69174 0 None 5 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 237 3 1 2 2.7 CC(=O)NCCc1csc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779803 69174 0 None 5 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 237 3 1 2 2.7 CC(=O)NCCc1csc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
86273229 128097 1 None 3 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 244 5 2 2 2.0 C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
CHEMBL3580909 128097 1 None 3 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 244 5 2 2 2.0 C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 10.1021/acs.jmedchem.5b00245
44389864 71110 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 380 10 2 2 4.7 CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL181192 71110 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 380 10 2 2 4.7 CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
44389839 71375 0 None -10 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 379 10 1 2 5.1 CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL181687 71375 0 None -10 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 379 10 1 2 5.1 CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
11165283 129910 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 392 9 2 2 4.8 CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL361206 129910 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 392 9 2 2 4.8 CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
137655489 165754 0 None 7 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 245 4 2 3 1.5 COc1cnc2cccc(CCNC(N)=O)c2c1 10.1016/j.ejmech.2016.12.013
CHEMBL4096197 165754 0 None 7 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 245 4 2 3 1.5 COc1cnc2cccc(CCNC(N)=O)c2c1 10.1016/j.ejmech.2016.12.013
56681902 71226 0 None -10 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 554 21 2 6 5.4 CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813323 71226 0 None -10 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 554 21 2 6 5.4 CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
54584155 67530 0 None 2 2 Human 5.4 pKi = 5.4 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 366 8 1 5 2.8 COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760949 67530 0 None 2 2 Human 5.4 pKi = 5.4 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 366 8 1 5 2.8 COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
11501012 84017 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 340 5 1 3 3.9 COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C 10.1021/jm0512544
CHEMBL207959 84017 0 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 340 5 1 3 3.9 COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C 10.1021/jm0512544
16105170 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1021/jm800974d
CHEMBL515696 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1021/jm800974d
16105170 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1016/j.bmc.2009.04.068
CHEMBL515696 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1016/j.bmc.2009.04.068
16743288 99102 0 None 14 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 338 5 1 2 4.7 CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 10.1016/j.ejmech.2007.01.005
CHEMBL243003 99102 0 None 14 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 338 5 1 2 4.7 CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 10.1016/j.ejmech.2007.01.005
162649850 186917 0 None 7 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4748822 186917 0 None 7 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 273 6 1 4 2.1 CCCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
162656758 187701 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4757920 187701 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1ncnc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
10637638 27373 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 295 5 1 2 3.4 COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3 10.1021/jm000922c
CHEMBL130813 27373 0 None -4 2 Human 7.4 pKi = 7.4 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 295 5 1 2 3.4 COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3 10.1021/jm000922c
16105170 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1021/jm401343c
CHEMBL515696 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to MT2 receptor (unknown origin)Binding affinity to MT2 receptor (unknown origin)
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1021/jm401343c
16105170 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1021/jm800974d
CHEMBL515696 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1021/jm800974d
16105170 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1016/j.bmc.2008.07.012
CHEMBL515696 196506 0 None 4 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 405 5 1 5 3.3 COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 10.1016/j.bmc.2008.07.012
162647716 186666 0 None 3 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
CHEMBL4745789 186666 0 None 3 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 259 5 1 4 1.7 CCC(=O)NCCc1nncc2ccc(OC)cc12 10.1016/j.ejmech.2020.112078
16094576 144910 6 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 253 5 1 1 3.1 CC(=O)NCC(Cc1ccccc1)c1ccccc1 10.1021/jm060850a
CHEMBL376693 144910 6 None 1 2 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 253 5 1 1 3.1 CC(=O)NCC(Cc1ccccc1)c1ccccc1 10.1021/jm060850a
45269183 202804 0 None 6 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 385 7 2 3 4.1 COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
CHEMBL560186 202804 0 None 6 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 385 7 2 3 4.1 COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
10704742 114038 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1cccc2cc(CCNC(C)=O)[nH]c12 10.1021/jm001125h
CHEMBL316952 114038 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1cccc2cc(CCNC(C)=O)[nH]c12 10.1021/jm001125h
44579261 193758 0 None 87 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.9 COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL490594 193758 0 None 87 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 363 6 2 3 3.9 COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
127038131 143429 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 363 9 1 3 4.4 CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3740052 143429 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 363 9 1 3 4.4 CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
137655126 165405 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 260 4 1 4 2.1 COC(=O)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
CHEMBL4092353 165405 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 260 4 1 4 2.1 COC(=O)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
49865425 22732 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 4 1 2 2.3 CC(=O)N[C@@H](C)CSc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223347 22732 0 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 4 1 2 2.3 CC(=O)N[C@@H](C)CSc1ccccc1 10.1016/j.bmc.2010.06.100
127038131 143429 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 363 9 1 3 4.4 CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3740052 143429 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 363 9 1 3 4.4 CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
86273222 128101 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580913 128101 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 243 3 1 4 2.5 COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 10.1021/acs.jmedchem.5b00245
44424022 90247 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 718 23 4 8 6.9 COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL220091 90247 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 718 23 4 8 6.9 COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
145964105 170997 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 475 12 2 5 4.9 CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4211018 170997 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 475 12 2 5 4.9 CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 10.1021/acs.jmedchem.8b00893
122162 9166 75 None 18 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1021/jm980684+
1363 9166 75 None 18 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1021/jm980684+
CHEMBL286615 9166 75 None 18 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1021/jm980684+
10664333 214962 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 332 4 1 2 4.3 CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 10.1021/jm980684+
CHEMBL9838 214962 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 332 4 1 2 4.3 CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 10.1021/jm980684+
11002150 114330 0 None 7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 334 6 1 3 3.7 COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1 10.1021/jm001125h
CHEMBL318871 114330 0 None 7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 334 6 1 3 3.7 COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1 10.1021/jm001125h
18007928 15437 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 485 12 2 4 5.5 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095504 15437 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 485 12 2 4 5.5 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12 10.1016/j.bmc.2010.04.008
44429455 94523 0 None 2 2 Human 6.3 pKi = 6.3 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 322 5 1 3 3.5 COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C 10.1016/j.bmc.2007.04.013
CHEMBL233740 94523 0 None 2 2 Human 6.3 pKi = 6.3 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 322 5 1 3 3.5 COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C 10.1016/j.bmc.2007.04.013
11287002 22701 2 None 4 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)N[C@@H](C)COc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223275 22701 2 None 4 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)N[C@@H](C)COc1ccccc1 10.1016/j.bmc.2010.06.100
3964826 22626 30 None 1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 5 1 3 1.2 COc1ccc(OCCNC(C)=O)cc1 10.1016/j.bmc.2010.06.100
CHEMBL1223054 22626 30 None 1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 5 1 3 1.2 COc1ccc(OCCNC(C)=O)cc1 10.1016/j.bmc.2010.06.100
127025170 144520 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 312 5 2 3 3.5 CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
CHEMBL3759180 144520 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 312 5 2 3 3.5 CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
162649247 186854 0 None 10 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 351 6 1 5 3.0 COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 10.1016/j.ejmech.2020.112078
CHEMBL4747996 186854 0 None 10 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 351 6 1 5 3.0 COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 10.1016/j.ejmech.2020.112078
46885230 14965 0 None 8 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 223 5 2 3 1.5 COc1ccc(O)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1092062 14965 0 None 8 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 223 5 2 3 1.5 COc1ccc(O)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
122162 9166 75 None 18 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1016/j.ejmech.2007.01.005
1363 9166 75 None 18 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1016/j.ejmech.2007.01.005
CHEMBL286615 9166 75 None 18 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10.1016/j.ejmech.2007.01.005
137656715 166326 0 None 5 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 308 5 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4102517 166326 0 None 5 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 308 5 1 2 3.0 CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
12985496 189110 0 None 31 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 7 2 3 4.5 COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL478438 189110 0 None 31 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 7 2 3 4.5 COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 10.1016/j.bmc.2008.08.052
49865317 22666 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 265 6 1 3 2.7 COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223191 22666 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 265 6 1 3 2.7 COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
49865374 22703 0 None 7 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OC[C@@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223277 22703 0 None 7 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OC[C@@H](C)NC(C)=O)c1 10.1016/j.bmc.2010.06.100
56653120 117646 0 None -12 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 336 8 2 2 3.9 CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12 10.1021/jm401343c
CHEMBL3260985 117646 0 None -12 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 336 8 2 2 3.9 CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12 10.1021/jm401343c
86273470 128100 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 256 4 1 3 3.3 COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580912 128100 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 256 4 1 3 3.3 COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 10.1021/acs.jmedchem.5b00245
20590653 130053 0 None -5 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 389 9 1 2 5.0 O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 10.1016/j.bmcl.2005.01.015
CHEMBL361410 130053 0 None -5 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 389 9 1 2 5.0 O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 10.1016/j.bmcl.2005.01.015
54581170 67537 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 359 4 1 4 1.8 COc1ccc2c(I)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760956 67537 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 359 4 1 4 1.8 COc1ccc2c(I)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
127040355 144691 0 None 13 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 410 5 1 4 5.5 COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3763537 144691 0 None 13 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 410 5 1 4 5.5 COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
127040022 144729 0 None 6 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 410 5 1 4 5.5 COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3764063 144729 0 None 6 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 410 5 1 4 5.5 COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
10641756 105054 0 None 57 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 352 3 1 2 4.6 CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2 10.1021/jm980684+
CHEMBL274630 105054 0 None 57 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 352 3 1 2 4.6 CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2 10.1021/jm980684+
16094587 90037 3 None 72 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 297 7 1 2 3.7 CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 10.1021/jm060850a
CHEMBL218774 90037 3 None 72 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 297 7 1 2 3.7 CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 10.1021/jm060850a
49865322 22671 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 267 7 1 3 3.1 CCCC(=O)NCC(C)Sc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223196 22671 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 267 7 1 3 3.1 CCCC(=O)NCC(C)Sc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
162674581 190091 0 None 51 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 268 3 1 4 2.7 COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
CHEMBL4797226 190091 0 None 51 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 268 3 1 4 2.7 COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1 10.1016/j.ejmech.2020.112090
11351216 69178 0 None 4 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 441 6 1 3 5.4 O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
CHEMBL1779807 69178 0 None 4 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 441 6 1 3 5.4 O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 10.1016/j.ejmech.2011.02.044
22718576 121383 0 None 4 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 1 3 2.2 CC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL333810 121383 0 None 4 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 232 4 1 3 2.2 CC(=O)NCCCc1cccc2nc(C)oc12 10.1016/j.bmcl.2004.04.082
3956219 108324 11 None 2 2 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 277 5 2 4 1.8 COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL298335 108324 11 None 2 2 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 277 5 2 4 1.8 COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-] 10.1021/jm011053+
16094595 90036 4 None 407 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 283 6 1 2 3.4 COc1cccc(C(CCNC(C)=O)c2ccccc2)c1 10.1021/jm060850a
CHEMBL218773 90036 4 None 407 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 283 6 1 2 3.4 COc1cccc(C(CCNC(C)=O)c2ccccc2)c1 10.1021/jm060850a
23658145 164242 1 None 33 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
CHEMBL4079214 164242 1 None 33 2 Human 8.3 pKi = 8.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 287 6 2 3 2.5 CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 10.1039/C4MD00149D
1347 6950 56 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 10.1016/j.ejmech.2019.111847
1864 6950 56 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 10.1016/j.ejmech.2019.111847
CHEMBL127421 6950 56 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
ChEMBL 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 10.1016/j.ejmech.2019.111847
44264849 212151 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 298 5 1 3 4.1 COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7990 212151 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 298 5 1 3 4.1 COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
10808489 214554 0 None 42 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 360 6 1 3 4.1 CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 10.1021/jm980684+
CHEMBL9600 214554 0 None 42 2 Human 8.3 pKi = 8.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 360 6 1 3 4.1 CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 10.1021/jm980684+
90666303 116157 0 None 31 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 361 6 2 3 3.9 COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1 10.1039/C1MD00149C
CHEMBL3219324 116157 0 None 31 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 361 6 2 3 3.9 COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1 10.1039/C1MD00149C
44358218 34289 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 289 4 2 3 1.9 CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL136895 34289 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 289 4 2 3 1.9 CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
15453819 211762 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 287 6 1 4 3.1 COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7659 211762 0 None 30 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 287 6 1 4 3.1 COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
49865267 22648 2 None 7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 225 5 1 3 1.9 COc1ccccc1SCCNC(C)=O 10.1016/j.bmc.2010.06.100
CHEMBL1223127 22648 2 None 7 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 225 5 1 3 1.9 COc1ccccc1SCCNC(C)=O 10.1016/j.bmc.2010.06.100
7778 7601 0 None -97 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 497 12 2 4 6.1 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2 10.1016/j.bmc.2010.04.008
9957516 7601 0 None -97 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 497 12 2 4 6.1 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2 10.1016/j.bmc.2010.04.008
CHEMBL1094546 7601 0 None -97 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 497 12 2 4 6.1 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2 10.1016/j.bmc.2010.04.008
49865148 22603 2 None 2 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1ccccc1OC(C)CNC(C)=O 10.1016/j.bmc.2010.06.100
CHEMBL1222984 22603 2 None 2 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1ccccc1OC(C)CNC(C)=O 10.1016/j.bmc.2010.06.100
44349269 23360 1 None 3 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 289 6 2 3 3.2 CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL123972 23360 1 None 3 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 289 6 2 3 3.2 CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
44394456 72890 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 378 10 2 2 5.3 CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL183962 72890 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 378 10 2 2 5.3 CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
23658143 163156 1 None 6 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
CHEMBL4066279 163156 1 None 6 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 291 6 2 3 2.0 COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 10.1039/C4MD00149D
24750195 95329 0 None 24 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 298 6 0 3 3.3 COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1 10.1021/jm700957j
CHEMBL235334 95329 0 None 24 2 Human 7.3 pKi = 7.3 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 298 6 0 3 3.3 COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1 10.1021/jm700957j
11791741 214889 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 344 4 1 2 4.3 O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1 10.1021/jm980684+
CHEMBL9791 214889 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 344 4 1 2 4.3 O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1 10.1021/jm980684+
16094592 90060 1 None 6 2 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 251 4 1 1 3.4 CC(=O)NC/C(=C/c1ccccc1)c1ccccc1 10.1021/jm060850a
CHEMBL218926 90060 1 None 6 2 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 251 4 1 1 3.4 CC(=O)NC/C(=C/c1ccccc1)c1ccccc1 10.1021/jm060850a
145966403 170987 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 497 13 2 6 4.9 CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4210884 170987 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 497 13 2 6 4.9 CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 10.1021/acs.jmedchem.8b00893
122178510 128108 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 275 4 2 4 3.0 COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580921 128108 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 275 4 2 4 3.0 COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 10.1021/acs.jmedchem.5b00245
162670470 189688 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 343 9 1 5 3.7 CCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O 10.1016/j.ejmech.2020.112090
CHEMBL4792353 189688 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 343 9 1 5 3.7 CCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O 10.1016/j.ejmech.2020.112090
86272988 128107 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 261 3 2 4 2.8 COc1ccc2[nH]cc(Cc3n[nH]c(=S)o3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580920 128107 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 261 3 2 4 2.8 COc1ccc2[nH]cc(Cc3n[nH]c(=S)o3)c2c1 10.1021/acs.jmedchem.5b00245
11310062 22700 2 None 1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)N[C@H](C)COc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223274 22700 2 None 1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 193 4 1 2 1.6 CC(=O)N[C@H](C)COc1ccccc1 10.1016/j.bmc.2010.06.100
44394416 73012 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 389 9 1 2 5.9 CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL184562 73012 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 389 9 1 2 5.9 CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
12436516 22628 6 None 2 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 179 4 1 2 1.2 CC(=O)NCCOc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223056 22628 6 None 2 2 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 179 4 1 2 1.2 CC(=O)NCCOc1ccccc1 10.1016/j.bmc.2010.06.100
54586060 67532 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 332 6 1 6 1.0 COc1ccc2c(CN3CCOCC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760951 67532 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 332 6 1 6 1.0 COc1ccc2c(CN3CCOCC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
137657824 166576 0 None 1 2 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 289 5 2 3 2.3 CCNC(=S)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
CHEMBL4105511 166576 0 None 1 2 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 289 5 2 3 2.3 CCNC(=S)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
86272986 128109 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 258 3 2 4 1.2 COc1ccc2[nH]cc(Cc3n[nH]c(=O)n3C)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580922 128109 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 258 3 2 4 1.2 COc1ccc2[nH]cc(Cc3n[nH]c(=O)n3C)c2c1 10.1021/acs.jmedchem.5b00245
22718548 23273 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 322 6 1 3 4.2 CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL123612 23273 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 322 6 1 3 4.2 CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
11543959 83899 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 6 2 2 3.5 CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 10.1021/jm0512544
CHEMBL207676 83899 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 6 2 2 3.5 CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 10.1021/jm0512544
44424026 149114 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 546 17 4 4 5.8 COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL388591 149114 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 546 17 4 4 5.8 COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 10.1016/j.bmc.2007.03.080
11666721 71764 0 None 18 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 309 5 1 4 2.7 CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12 10.1016/j.ejmech.2011.06.030
CHEMBL1823016 71764 0 None 18 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 309 5 1 4 2.7 CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12 10.1016/j.ejmech.2011.06.030
127039218 144674 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 234 4 1 4 1.5 COc1cc2c(CCNC(C)=O)coc2cn1 10.1016/j.ejmech.2016.01.008
CHEMBL3763247 144674 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 234 4 1 4 1.5 COc1cc2c(CCNC(C)=O)coc2cn1 10.1016/j.ejmech.2016.01.008
46845151 15438 0 None -38 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 499 12 2 4 6.1 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095505 15438 0 None -38 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 499 12 2 4 6.1 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 10.1016/j.bmc.2010.04.008
137656978 166542 0 None 147 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 294 4 1 2 3.1 CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
CHEMBL4105125 166542 0 None 147 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 294 4 1 2 3.1 CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1 10.1021/acs.jmedchem.8b00359
137661786 165894 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 262 5 1 3 1.9 COc1cnc2cccc(CCNC(=O)CF)c2c1 10.1016/j.ejmech.2016.12.013
CHEMBL4097693 165894 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 262 5 1 3 1.9 COc1cnc2cccc(CCNC(=O)CF)c2c1 10.1016/j.ejmech.2016.12.013
44394535 73787 0 None -2 2 Human 8.2 pKi = 8.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 390 8 1 3 5.1 CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
CHEMBL186977 73787 0 None -2 2 Human 8.2 pKi = 8.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 390 8 1 3 5.1 CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
16094580 88333 4 None 11 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 283 6 1 2 3.0 COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1 10.1021/jm060850a
CHEMBL216158 88333 4 None 11 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 283 6 1 2 3.0 COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1 10.1021/jm060850a
49865324 22673 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 267 7 1 3 3.1 CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223198 22673 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 267 7 1 3 3.1 CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
24955342 70564 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 321 4 1 4 2.6 CC(=O)NCCc1c(-c2ccccc2)nc2ccc3c(n12)CCO3 10.1021/jm200385u
CHEMBL1802020 70564 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 321 4 1 4 2.6 CC(=O)NCCc1c(-c2ccccc2)nc2ccc3c(n12)CCO3 10.1021/jm200385u
23725513 132626 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
CHEMBL3648357 132626 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay
ChEMBL 258 3 1 3 2.7 CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 10.1021/acs.jmedchem.0c01836
10760155 105195 0 None 43 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 4 1 3 3.9 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL275529 105195 0 None 43 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 348 4 1 3 3.9 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 10.1021/jm980684+
145976009 170311 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 541 15 3 4 7.0 CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 10.1021/acs.jmedchem.8b00893
CHEMBL4202816 170311 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 541 15 3 4 7.0 CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 10.1021/acs.jmedchem.8b00893
44358312 36595 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 3 1 3 2.0 CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL138744 36595 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 3 1 3 2.0 CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
10829695 125983 0 None 21 2 Human 8.2 pKi = 8.2 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 322 6 1 3 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 10.1021/jm020982d
CHEMBL34327 125983 0 None 21 2 Human 8.2 pKi = 8.2 Binding
Binding Affinity (pKi) towards human Melatonin receptor type 1BBinding Affinity (pKi) towards human Melatonin receptor type 1B
ChEMBL 322 6 1 3 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 10.1021/jm020982d
10829695 125983 0 None 21 2 Human 8.2 pKi = 8.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 322 6 1 3 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 10.1021/jm048956y
CHEMBL34327 125983 0 None 21 2 Human 8.2 pKi = 8.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 322 6 1 3 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 10.1021/jm048956y
10596576 10945 0 None 39 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 390 7 1 3 5.1 CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2 10.1021/jm980684+
CHEMBL10007 10945 0 None 39 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 390 7 1 3 5.1 CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2 10.1021/jm980684+
71540395 93191 0 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 256 3 2 2 2.7 CNC(=O)N/C=C/c1c(OC)ccc2ccccc12 10.1016/j.bmcl.2012.11.069
CHEMBL2314258 93191 0 None -2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 256 3 2 2 2.7 CNC(=O)N/C=C/c1c(OC)ccc2ccccc12 10.1016/j.bmcl.2012.11.069
10163052 15293 0 None -72 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 483 12 2 4 5.9 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1094212 15293 0 None -72 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 483 12 2 4 5.9 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 10.1016/j.bmc.2010.04.008
44317725 212450 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 329 9 1 3 4.1 CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC 10.1016/S0960-894X(97)00444-7
CHEMBL82135 212450 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 329 9 1 3 4.1 CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC 10.1016/S0960-894X(97)00444-7
49865318 22667 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 265 6 1 3 2.7 COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223192 22667 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 265 6 1 3 2.7 COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
18360631 15487 0 None -26 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 516 13 2 4 5.7 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095831 15487 0 None -26 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 516 13 2 4 5.7 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12 10.1016/j.bmc.2010.04.008
9881917 103816 0 None 44 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 271 5 1 3 3.8 CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL266970 103816 0 None 44 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 271 5 1 3 3.8 CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
71540275 93184 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 225 2 1 1 2.8 CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12 10.1016/j.bmcl.2012.11.069
CHEMBL2314250 93184 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 225 2 1 1 2.8 CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12 10.1016/j.bmcl.2012.11.069
44241665 202479 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 329 6 1 4 2.6 CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2 10.1016/j.bmc.2009.04.068
CHEMBL556908 202479 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 329 6 1 4 2.6 CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2 10.1016/j.bmc.2009.04.068
168288029 198400 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 471 9 1 9 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
CHEMBL5195595 198400 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
ChEMBL 471 9 1 9 3.4 COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] 10.1021/acs.jmedchem.2c00717
10384120 131169 0 None -7 2 Human 7.2 pKi = 7.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 363 10 1 2 5.5 CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL363936 131169 0 None -7 2 Human 7.2 pKi = 7.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 363 10 1 2 5.5 CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
25022442 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1021/jm800974d
CHEMBL514413 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1021/jm800974d
145977894 170628 0 None -3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 372 11 2 5 3.2 CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1 10.1021/acs.jmedchem.8b00893
CHEMBL4206516 170628 0 None -3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 372 11 2 5 3.2 CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1 10.1021/acs.jmedchem.8b00893
11314110 77513 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 350 6 1 3 4.3 CCC(=O)NCc1cc2c(OC)cccc2n1Cc1c(C)cccc1C 10.1021/jm048956y
CHEMBL195074 77513 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 350 6 1 3 4.3 CCC(=O)NCc1cc2c(OC)cccc2n1Cc1c(C)cccc1C 10.1021/jm048956y
44349294 25325 1 None 5 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 323 6 2 3 3.7 CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL127576 25325 1 None 5 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 323 6 2 3 3.7 CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
44429453 94316 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 322 6 2 2 3.9 CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL233517 94316 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 322 6 2 2 3.9 CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
11500596 145457 0 None 7 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 312 5 2 2 3.5 COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1 10.1021/jm0512544
CHEMBL377809 145457 0 None 7 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 312 5 2 2 3.5 COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1 10.1021/jm0512544
44424018 92133 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 620 16 4 8 4.2 COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL226162 92133 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 620 16 4 8 4.2 COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
45268310 203342 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 419 7 2 3 4.5 COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
CHEMBL563847 203342 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 419 7 2 3 4.5 COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
10807560 214926 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 346 5 1 2 4.7 CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 10.1021/jm980684+
CHEMBL9815 214926 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 346 5 1 2 4.7 CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 10.1021/jm980684+
45268310 203342 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 419 7 2 3 4.5 COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
CHEMBL563847 203342 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 419 7 2 3 4.5 COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
44264689 211830 1 None -1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 282 5 2 3 3.8 COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7713 211830 1 None -1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 282 5 2 3 3.8 COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1 10.1016/j.bmcl.2003.11.030
25022442 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1016/j.bmc.2009.04.068
CHEMBL514413 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1016/j.bmc.2009.04.068
10563168 126470 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 258 4 2 2 2.6 COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12 10.1021/jm001125h
CHEMBL34729 126470 0 None -1 2 Human 6.2 pKi = 6.2 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 258 4 2 2 2.6 COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12 10.1021/jm001125h
49865424 22731 0 None 1 2 Human 4.2 pKi = 4.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 4 1 2 2.3 CC(=O)N[C@H](C)CSc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223346 22731 0 None 1 2 Human 4.2 pKi = 4.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 4 1 2 2.3 CC(=O)N[C@H](C)CSc1ccccc1 10.1016/j.bmc.2010.06.100
25022442 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1021/jm800974d
CHEMBL514413 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1021/jm800974d
44424019 92134 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 648 18 4 8 5.0 COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL226163 92134 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 648 18 4 8 5.0 COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
25022442 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1016/j.bmc.2008.07.012
CHEMBL514413 196338 0 None 5 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 375 4 1 4 3.3 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 10.1016/j.bmc.2008.07.012
11536746 146229 0 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 4 1 3 3.1 COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C 10.1021/jm0512544
CHEMBL379403 146229 0 None 2 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 4 1 3 3.1 COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C 10.1021/jm0512544
45267465 201546 0 None 1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 365 8 2 3 3.5 COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
CHEMBL538129 201546 0 None 1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 365 8 2 3 3.5 COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2009.04.068
16094579 87617 5 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 267 6 1 1 3.3 CCC(=O)NCCc1cccc(Cc2ccccc2)c1 10.1021/jm060850a
CHEMBL215252 87617 5 None -1 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in NIH3T3 cells
ChEMBL 267 6 1 1 3.3 CCC(=O)NCCc1cccc(Cc2ccccc2)c1 10.1021/jm060850a
49865205 22624 0 None 4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(S[C@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223052 22624 0 None 4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(S[C@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
4207624 22627 37 None 5 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 5 1 3 1.2 COc1ccccc1OCCNC(C)=O 10.1016/j.bmc.2010.06.100
CHEMBL1223055 22627 37 None 5 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 5 1 3 1.2 COc1ccccc1OCCNC(C)=O 10.1016/j.bmc.2010.06.100
49865320 22669 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 251 7 1 3 2.4 CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223194 22669 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 251 7 1 3 2.4 CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1 10.1016/j.bmc.2010.06.100
44436051 158142 6 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 5 1 3 1.2 COc1cccc(OCCNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL396132 158142 6 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 5 1 3 1.2 COc1cccc(OCCNC(C)=O)c1 10.1016/j.bmc.2010.06.100
44429456 94704 0 None 8 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 336 6 1 3 3.9 CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL233945 94704 0 None 8 2 Human 6.2 pKi = 6.2 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 336 6 1 3 3.9 CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
49865423 22730 2 None 4 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 4 1 2 2.3 CC(=O)NC(C)CSc1ccccc1 10.1016/j.bmc.2010.06.100
CHEMBL1223345 22730 2 None 4 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 209 4 1 2 2.3 CC(=O)NC(C)CSc1ccccc1 10.1016/j.bmc.2010.06.100
122178508 128104 0 None 8 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 243 4 1 4 2.3 COc1ccc2[nH]cc(CCc3nnco3)c2c1 10.1021/acs.jmedchem.5b00245
CHEMBL3580917 128104 0 None 8 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
ChEMBL 243 4 1 4 2.3 COc1ccc2[nH]cc(CCc3nnco3)c2c1 10.1021/acs.jmedchem.5b00245
162672373 189866 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 298 4 1 5 2.7 COc1cc2cccc(/C=C/c3n[nH]c(=O)o3)c2cc1OC 10.1016/j.ejmech.2020.112090
CHEMBL4794450 189866 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis
ChEMBL 298 4 1 5 2.7 COc1cc2cccc(/C=C/c3n[nH]c(=O)o3)c2cc1OC 10.1016/j.ejmech.2020.112090
46884554 15070 0 None 128 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 313 8 1 3 3.3 COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1 10.1016/j.bmcl.2010.02.084
CHEMBL1092647 15070 0 None 128 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 313 8 1 3 3.3 COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1 10.1016/j.bmcl.2010.02.084
127027022 144587 0 None 19 3 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 314 4 2 3 3.6 CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
CHEMBL3759677 144587 0 None 19 3 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins
ChEMBL 314 4 2 3 3.6 CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 10.1016/j.ejmech.2015.12.047
10104923 108277 2 None 12 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 221 6 1 2 2.2 CCC(=O)NCCCc1cccc(OC)c1 10.1016/j.bmcl.2010.02.084
CHEMBL297947 108277 2 None 12 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 221 6 1 2 2.2 CCC(=O)NCCCc1cccc(OC)c1 10.1016/j.bmcl.2010.02.084
25209998 196521 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 393 7 2 4 3.4 COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1021/jm800974d
CHEMBL515856 196521 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 393 7 2 4 3.4 COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1021/jm800974d
49865206 22625 1 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(S[C@@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223053 22625 1 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 239 5 1 3 2.3 COc1cccc(S[C@@H](C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
25209998 196521 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 393 7 2 4 3.4 COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1021/jm800974d
CHEMBL515856 196521 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 393 7 2 4 3.4 COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O 10.1021/jm800974d
44264843 211626 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 300 5 1 4 4.0 CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
CHEMBL7556 211626 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 300 5 1 4 4.0 CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 10.1016/j.bmcl.2003.11.030
44394508 72919 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 404 9 1 3 5.5 CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
CHEMBL184144 72919 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 404 9 1 3 5.5 CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
18466111 26617 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
CHEMBL130214 26617 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
ChEMBL 283 5 1 2 3.4 CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 10.1021/jm000922c
24750070 160332 4 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 208 5 2 3 1.2 COc1cccc(NCCNC(C)=O)c1 10.1021/jm700957j
CHEMBL398017 160332 4 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 208 5 2 3 1.2 COc1cccc(NCCNC(C)=O)c1 10.1021/jm700957j
11688043 84770 0 None 28 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 6 1 3 3.1 CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 10.1021/jm0512544
CHEMBL209712 84770 0 None 28 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 300 6 1 3 3.1 CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 10.1021/jm0512544
44579296 193573 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 6 2 3 4.2 COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
CHEMBL489170 193573 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 376 6 2 3 4.2 COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.08.052
10639585 121241 0 None 83 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 322 6 1 3 3.7 CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1 10.1021/jm001125h
CHEMBL33346 121241 0 None 83 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 322 6 1 3 3.7 CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1 10.1021/jm001125h
44349362 23346 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 286 7 1 3 3.2 CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
CHEMBL123899 23346 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 286 7 1 3 3.2 CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 10.1016/j.bmcl.2004.04.082
44424020 92137 0 None 7 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 676 20 4 8 5.8 COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL226171 92137 0 None 7 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 676 20 4 8 5.8 COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
10518884 119331 0 None 11 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 308 5 1 3 3.3 COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1 10.1021/jm001125h
CHEMBL329979 119331 0 None 11 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 308 5 1 3 3.3 COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1 10.1021/jm001125h
127041168 143382 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 388 10 2 3 3.9 O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F 10.1039/C5MD00190K
CHEMBL3739674 143382 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 388 10 2 3 3.9 O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F 10.1039/C5MD00190K
45268303 203524 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 301 4 1 4 1.8 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1 10.1016/j.bmc.2009.04.068
CHEMBL565176 203524 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 301 4 1 4 1.8 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1 10.1016/j.bmc.2009.04.068
127041168 143382 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 388 10 2 3 3.9 O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F 10.1039/C5MD00190K
CHEMBL3739674 143382 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 388 10 2 3 3.9 O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F 10.1039/C5MD00190K
25022429 194928 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 393 7 3 4 2.8 COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.07.012
CHEMBL498493 194928 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
ChEMBL 393 7 3 4 2.8 COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2008.07.012
16750566 148810 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 662 19 4 8 5.4 COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL387655 148810 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 662 19 4 8 5.4 COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 10.1016/j.bmc.2007.03.080
16743124 98984 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 282 5 1 2 3.0 O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1 10.1016/j.ejmech.2007.01.005
CHEMBL242573 98984 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 282 5 1 2 3.0 O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1 10.1016/j.ejmech.2007.01.005
11616210 146236 0 None 6 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 4 1 3 2.7 COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C 10.1021/jm0512544
CHEMBL379413 146236 0 None 6 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 286 4 1 3 2.7 COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C 10.1021/jm0512544
46885287 14941 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 341 10 1 3 3.8 COc1ccc(OCCCc2ccccc2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
CHEMBL1091896 14941 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 341 10 1 3 3.8 COc1ccc(OCCCc2ccccc2)c(CCCNC(C)=O)c1 10.1016/j.bmcl.2010.02.084
1355 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm0255872
9806449 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm0255872
CHEMBL14453 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm0255872
1355 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1016/j.bmc.2010.04.008
9806449 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1016/j.bmc.2010.04.008
CHEMBL14453 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1016/j.bmc.2010.04.008
44424025 91949 0 None -1 2 Human 5.1 pKi = 5.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 504 14 4 4 4.6 COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 10.1016/j.bmc.2007.03.080
CHEMBL225302 91949 0 None -1 2 Human 5.1 pKi = 5.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells
ChEMBL 504 14 4 4 4.6 COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 10.1016/j.bmc.2007.03.080
137633839 163389 0 None 7 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 273 5 2 3 2.1 CCNC(=O)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
CHEMBL4068922 163389 0 None 7 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 mins
ChEMBL 273 5 2 3 2.1 CCNC(=O)NCCc1cccc2ncc(OC)cc12 10.1016/j.ejmech.2016.12.013
10526493 212073 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 427 8 1 3 3.7 CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
CHEMBL79224 212073 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 427 8 1 3 3.7 CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12 10.1016/S0960-894X(97)00444-7
1355 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
9806449 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
CHEMBL14453 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT2 receptor (unknown origin) expressed in HEK cells
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1021/jm401343c
1355 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
9806449 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
CHEMBL14453 10211 5 None -70 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins
ChEMBL 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 10.1039/C5MD00190K
54582194 67531 0 None -1 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 330 6 1 5 2.2 COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760950 67531 0 None -1 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 330 6 1 5 2.2 COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
54583161 67534 0 None 1 2 Human 5.1 pKi = 5.1 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 452 8 1 6 3.4 COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760953 67534 0 None 1 2 Human 5.1 pKi = 5.1 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 452 8 1 6 3.4 COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
10849065 6925 8 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 262 6 3 3 1.2 OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
1345 6925 8 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 262 6 3 3 1.2 OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
CHEMBL126809 6925 8 None -4 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis
ChEMBL 262 6 3 3 1.2 OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10.1016/j.ejmech.2019.111847
11109646 213851 0 None 7 2 Human 7.1 pKi = 7.1 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 309 5 2 3 3.4 CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12 10.1021/jm0005252
CHEMBL91813 213851 0 None 7 2 Human 7.1 pKi = 7.1 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 309 5 2 3 3.4 CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12 10.1021/jm0005252
54770909 71766 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 339 6 2 5 2.0 COc1ccc2nc(-c3ccccc3)c(CC(CO)NC(C)=O)n2c1 10.1016/j.ejmech.2011.06.030
CHEMBL1823018 71766 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 339 6 2 5 2.0 COc1ccc2nc(-c3ccccc3)c(CC(CO)NC(C)=O)n2c1 10.1016/j.ejmech.2011.06.030
162658247 187797 0 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2cnnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
CHEMBL4759137 187797 0 None 2 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assay
ChEMBL 245 4 1 4 1.3 COc1ccc2cnnc(CCNC(C)=O)c2c1 10.1016/j.ejmech.2020.112078
12071674 130721 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 351 9 1 2 4.5 CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL362849 130721 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 351 9 1 2 4.5 CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
25209861 181998 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 8 2 3 4.6 CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 10.1021/jm800974d
CHEMBL457138 181998 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 8 2 3 4.6 CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 10.1021/jm800974d
11702296 71765 6 None 3 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 309 5 1 4 2.7 COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1 10.1016/j.ejmech.2011.06.030
CHEMBL1823017 71765 6 None 3 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in human HEK293 cells by radioligand binding assay
ChEMBL 309 5 1 4 2.7 COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1 10.1016/j.ejmech.2011.06.030
127041169 143626 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 570 14 2 4 5.7 O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
CHEMBL3741890 143626 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 570 14 2 4 5.7 O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
127041169 143626 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 570 14 2 4 5.7 O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
CHEMBL3741890 143626 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 570 14 2 4 5.7 O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F 10.1039/C5MD00190K
25209861 181998 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 8 2 3 4.6 CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 10.1021/jm800974d
CHEMBL457138 181998 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 405 8 2 3 4.6 CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 10.1021/jm800974d
10969292 214611 0 None 7 2 Human 8.1 pKi = 8.1 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 321 6 1 2 4.3 CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL96333 214611 0 None 7 2 Human 8.1 pKi = 8.1 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 321 6 1 2 4.3 CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
44579164 188909 0 None 14 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 406 7 2 4 4.8 CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
CHEMBL478218 188909 0 None 14 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 406 7 2 4 4.8 CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 10.1016/j.bmc.2008.08.052
46888520 15415 0 None -10 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 538 15 2 4 6.1 C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095195 15415 0 None -10 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 538 15 2 4 6.1 C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
10428383 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity at human MT2 receptorAntagonist activity at human MT2 receptor
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm401343c
7783 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity at human MT2 receptorAntagonist activity at human MT2 receptor
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm401343c
CHEMBL33185 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity at human MT2 receptorAntagonist activity at human MT2 receptor
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm401343c
10428383 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm001125h
7783 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm001125h
CHEMBL33185 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm001125h
10428383 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm048956y
7783 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm048956y
CHEMBL33185 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm048956y
127038132 143592 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 361 9 1 2 4.9 CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3741561 143592 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 361 9 1 2 4.9 CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 10.1039/C5MD00190K
90666304 116158 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 401 7 2 3 4.6 COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 10.1039/C1MD00149C
CHEMBL3219325 116158 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 401 7 2 3 4.6 COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 10.1039/C1MD00149C
10656443 215154 2 None 1 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 218 3 2 2 1.8 COc1cccc2[nH]c(CNC(C)=O)cc12 10.1021/jm001125h
CHEMBL99534 215154 2 None 1 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 218 3 2 2 1.8 COc1cccc2[nH]c(CNC(C)=O)cc12 10.1021/jm001125h
56678563 71223 0 None -14 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 484 16 2 6 3.5 CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813320 71223 0 None -14 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 484 16 2 6 3.5 CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
18522267 73099 0 None -5 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 377 11 1 2 5.8 CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL184990 73099 0 None -5 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 377 11 1 2 5.8 CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
10956792 108588 7 None 1 2 Human 6.1 pKi = 6.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 277 5 2 4 1.8 COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-] 10.1021/jm011053+
CHEMBL300195 108588 7 None 1 2 Human 6.1 pKi = 6.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
ChEMBL 277 5 2 4 1.8 COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-] 10.1021/jm011053+
10022490 73831 0 None -22 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 377 10 1 2 5.7 CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL187186 73831 0 None -22 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 377 10 1 2 5.7 CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
44264692 212012 1 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 284 5 2 3 4.0 COc1cccc(Nc2ccc(NC(=O)C(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
CHEMBL7874 212012 1 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human melatonin receptor type 1BBinding affinity towards human melatonin receptor type 1B
ChEMBL 284 5 2 3 4.0 COc1cccc(Nc2ccc(NC(=O)C(C)C)cc2)c1 10.1016/j.bmcl.2003.11.030
46888491 15443 0 None -20 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 501 13 3 4 4.9 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
CHEMBL1095522 15443 0 None -20 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 501 13 3 4 4.9 CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12 10.1016/j.bmc.2010.04.008
44358087 123191 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 3 1 3 2.0 CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
CHEMBL336024 123191 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cellsBinding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
ChEMBL 274 3 1 3 2.0 CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 10.1016/j.bmcl.2003.09.030
10620323 215119 0 None 34 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 388 6 1 3 4.7 CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 10.1021/jm980684+
CHEMBL9935 215119 0 None 34 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 388 6 1 3 4.7 CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 10.1021/jm980684+
11595087 83442 0 None 6 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 328 6 1 3 3.9 CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 10.1021/jm0512544
CHEMBL206419 83442 0 None 6 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 328 6 1 3 3.9 CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 10.1021/jm0512544
11277044 133380 1 None 6 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 263 2 1 1 3.3 CC(=O)NCC1=Cc2ccccc2Cc2ccccc21 10.1021/jm040768k
CHEMBL365249 133380 1 None 6 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 263 2 1 1 3.3 CC(=O)NCC1=Cc2ccccc2Cc2ccccc21 10.1021/jm040768k
45269177 201644 0 None 3 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 299 5 1 3 2.5 CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2 10.1016/j.bmc.2009.04.068
CHEMBL540182 201644 0 None 3 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 299 5 1 3 2.5 CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2 10.1016/j.bmc.2009.04.068
44429457 176130 0 None 6 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 350 7 1 3 4.3 CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL441916 176130 0 None 6 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 350 7 1 3 4.3 CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
71540390 93193 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 235 4 1 3 1.7 COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1 10.1016/j.bmcl.2012.11.069
CHEMBL2314263 93193 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
ChEMBL 235 4 1 3 1.7 COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1 10.1016/j.bmcl.2012.11.069
56653479 117647 0 None -10 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 352 9 2 3 3.7 CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3260986 117647 0 None -10 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 352 9 2 3 3.7 CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
56653479 117647 0 None -10 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 352 9 2 3 3.7 CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 10.1021/jm401343c
CHEMBL3260986 117647 0 None -10 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 352 9 2 3 3.7 CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 10.1021/jm401343c
56653479 117647 0 None -10 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 352 9 2 3 3.7 CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3260986 117647 0 None -10 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 352 9 2 3 3.7 CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 10.1039/C5MD00190K
44429454 155994 0 None 1 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 336 7 2 2 4.3 CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
CHEMBL394408 155994 0 None 1 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 336 7 2 2 4.3 CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 10.1016/j.bmc.2007.04.013
22718555 23361 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 6 1 3 3.7 CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL123973 23361 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 288 6 1 3 3.7 CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12 10.1016/j.bmcl.2004.04.082
22718530 24719 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 294 5 1 3 3.6 CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
CHEMBL126005 24719 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
ChEMBL 294 5 1 3 3.6 CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 10.1016/j.bmcl.2004.04.082
11219713 132621 0 None 4 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 279 3 1 1 3.4 CC(=O)NCCC1Cc2ccccc2Cc2ccccc21 10.1021/jm040768k
CHEMBL364835 132621 0 None 4 2 Human 7.1 pKi = 7.1 Binding
Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
ChEMBL 279 3 1 1 3.4 CC(=O)NCCC1Cc2ccccc2Cc2ccccc21 10.1021/jm040768k
45268318 203105 0 None 6 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 315 4 1 4 2.2 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1 10.1016/j.bmc.2009.04.068
CHEMBL562328 203105 0 None 6 2 Human 6.1 pKi = 6.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 315 4 1 4 2.2 COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1 10.1016/j.bmc.2009.04.068
127038130 143401 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 347 8 1 2 4.5 CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3739824 143401 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 347 8 1 2 4.5 CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 10.1039/C5MD00190K
127038132 143592 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 361 9 1 2 4.9 CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 10.1039/C5MD00190K
CHEMBL3741561 143592 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in CHO cells after 1 hr by gamma counting analysis
ChEMBL 361 9 1 2 4.9 CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 10.1039/C5MD00190K
145979282 173454 0 None 16 3 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4281915 173454 0 None 16 3 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 300 3 2 2 3.0 CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
10428383 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm800974d
7783 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm800974d
CHEMBL33185 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 10.1021/jm800974d
45270052 202172 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 381 8 2 4 3.5 COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 10.1016/j.bmc.2009.04.068
CHEMBL552002 202172 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 381 8 2 4 3.5 COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 10.1016/j.bmc.2009.04.068
127038225 144766 0 None 13 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 338 5 1 4 3.8 COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
CHEMBL3764421 144766 0 None 13 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT2 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
ChEMBL 338 5 1 4 3.8 COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1 10.1016/j.ejmech.2016.01.008
10853020 104942 0 None 15 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 318 4 1 2 3.9 CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 10.1021/jm980684+
CHEMBL273897 104942 0 None 15 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
ChEMBL 318 4 1 2 3.9 CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 10.1021/jm980684+
90666307 116161 0 None 2 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 8 2 3 3.9 C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 10.1039/C1MD00149C
CHEMBL3219328 116161 0 None 2 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in CHO cells
ChEMBL 389 8 2 3 3.9 C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 10.1039/C1MD00149C
45270052 202172 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 381 8 2 4 3.5 COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 10.1016/j.bmc.2009.04.068
CHEMBL552002 202172 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells by gamma counting
ChEMBL 381 8 2 4 3.5 COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 10.1016/j.bmc.2009.04.068
49865149 22605 2 None -2 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OC(C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
CHEMBL1222986 22605 2 None -2 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 223 5 1 3 1.6 COc1cccc(OC(C)CNC(C)=O)c1 10.1016/j.bmc.2010.06.100
10959837 214357 0 None 4 2 Human 8.0 pKi = 8.0 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 379 10 1 3 5.3 CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
CHEMBL94919 214357 0 None 4 2 Human 8.0 pKi = 8.0 Binding
Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
ChEMBL 379 10 1 3 5.3 CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 10.1021/jm0005252
49865270 22652 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 265 6 1 3 2.7 COc1cccc(SC(C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
CHEMBL1223131 22652 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cells after 90 mins
ChEMBL 265 6 1 3 2.7 COc1cccc(SC(C)CNC(=O)C2CC2)c1 10.1016/j.bmc.2010.06.100
9909783 73910 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 415 6 0 3 5.4 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1021/jm048956y
CHEMBL187525 73910 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
ChEMBL 415 6 0 3 5.4 COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 10.1021/jm048956y
44389768 71317 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 426 9 2 2 5.5 CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL181457 71317 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 426 9 2 2 5.5 CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
20590665 130407 0 None -14 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 391 9 1 2 5.3 CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
CHEMBL361854 130407 0 None -14 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
ChEMBL 391 9 1 2 5.3 CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 10.1016/j.bmcl.2005.01.015
11616029 84769 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 272 4 1 3 2.4 COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C 10.1021/jm0512544
CHEMBL209711 84769 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
ChEMBL 272 4 1 3 2.4 COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C 10.1021/jm0512544
20590664 130450 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 390 9 2 2 5.4 CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
CHEMBL362097 130450 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 390 9 2 2 5.4 CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12 10.1016/j.bmcl.2004.07.055
24763223 7004 0 None -74 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins
ChEMBL 340 10 1 3 3.7 CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C 10.1039/C5MD00190K
8289 7004 0 None -74 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins
ChEMBL 340 10 1 3 3.7 CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C 10.1039/C5MD00190K
CHEMBL3260987 7004 0 None -74 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins
ChEMBL 340 10 1 3 3.7 CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C 10.1039/C5MD00190K
681 8247 72 None -42 38 Human 5.0 pKi = 5.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1016/S0960-894X(97)00444-7
940 8247 72 None -42 38 Human 5.0 pKi = 5.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1016/S0960-894X(97)00444-7
947 8247 72 None -42 38 Human 5.0 pKi = 5.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1016/S0960-894X(97)00444-7
CHEMBL59 8247 72 None -42 38 Human 5.0 pKi = 5.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1016/S0960-894X(97)00444-7
DB00988 8247 72 None -42 38 Human 5.0 pKi = 5.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1016/S0960-894X(97)00444-7
54586061 67533 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 441 7 1 6 3.2 COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
CHEMBL1760952 67533 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cells
ChEMBL 441 7 1 6 3.2 COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1 10.1016/j.bmcl.2011.02.097
56671856 71225 0 None -4 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 526 19 2 6 4.6 CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
CHEMBL1813322 71225 0 None -4 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in mouse NIH-3T3 cell membrane
ChEMBL 526 19 2 6 4.6 CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 10.1016/j.bmc.2011.06.063
10513751 170073 1 None -1 2 Human 6.0 pKi = 6.0 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1cccc2[nH]c(CCNC(C)=O)cc12 10.1021/jm001125h
CHEMBL418789 170073 1 None -1 2 Human 6.0 pKi = 6.0 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1cccc2[nH]c(CCNC(C)=O)cc12 10.1021/jm001125h
10513752 115277 3 None 1 2 Human 5.0 pKi = 5.0 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2[nH]c(CCNC(C)=O)cc2c1 10.1021/jm001125h
CHEMBL319970 115277 3 None 1 2 Human 5.0 pKi = 5.0 Binding
Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatoninBinding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
ChEMBL 232 4 2 2 1.9 COc1ccc2[nH]c(CCNC(C)=O)cc2c1 10.1021/jm001125h
18522272 72863 0 None -15 2 Human 7.0 pKi = 7.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 375 10 1 2 5.5 O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 10.1016/j.bmcl.2004.07.055
CHEMBL183846 72863 0 None -15 2 Human 7.0 pKi = 7.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 375 10 1 2 5.5 O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 10.1016/j.bmcl.2004.07.055
16743294 98856 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 256 4 1 2 2.7 CC(=O)NCCCc1cn2c3c(cccc13)CCC2 10.1016/j.ejmech.2007.01.005
CHEMBL241928 98856 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT2 receptor expressed in NIH 3T3 cells
ChEMBL 256 4 1 2 2.7 CC(=O)NCCCc1cn2c3c(cccc13)CCC2 10.1016/j.ejmech.2007.01.005
CHEMBL3109562 217869 0 None 2 2 Human 7.0 pKi = 7.0 Binding
Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins
ChEMBL None None None CCC1=C(C)C2=Cc3c(CCNC(C)=O)c4cc(OC)ccc4n3[B-](F)(F)[N+]2=C1C 10.1021/ml4004155
145982333 173336 0 None -1 3 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
CHEMBL4279639 173336 0 None -1 3 Human 6.0 pKi = 6.0 Binding
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding method
ChEMBL 284 3 2 2 2.8 CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 10.1016/j.ejmech.2017.10.025
44394338 128821 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 405 8 2 3 4.9 CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
CHEMBL359561 128821 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
ChEMBL 405 8 2 3 4.9 CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 10.1016/j.bmcl.2004.07.055
1357 9263 139 None 1 9 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10696085
1672 9263 139 None 1 9 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10696085
224 9263 139 None 1 9 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10696085
896 9263 139 None 1 9 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10696085
CHEMBL45 9263 139 None 1 9 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10696085
DB01065 9263 139 None 1 9 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 10696085
1358 6912 41 125I-Iodomelatonin 870 2 Human 11.0 pKi = 11 Binding
NoneNone
PDSP KiDatabase 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 None
3976006 6912 41 125I-Iodomelatonin 870 2 Human 11.0 pKi = 11 Binding
NoneNone
PDSP KiDatabase 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 None
CHEMBL285718 6912 41 125I-Iodomelatonin 870 2 Human 11.0 pKi = 11 Binding
NoneNone
PDSP KiDatabase 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 None
198 7101 126 125I-Iodomelatonin 1 6 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
82148 7101 126 125I-Iodomelatonin 1 6 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
99 7101 126 125I-Iodomelatonin 1 6 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
CHEMBL10878 7101 126 125I-Iodomelatonin 1 6 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
DB06594 7101 126 125I-Iodomelatonin 1 6 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
198 7101 126 125I-Iodomelatonin 1 6 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
82148 7101 126 125I-Iodomelatonin 1 6 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
99 7101 126 125I-Iodomelatonin 1 6 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
CHEMBL10878 7101 126 125I-Iodomelatonin 1 6 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
DB06594 7101 126 125I-Iodomelatonin 1 6 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 10.0 pKi = 10.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 10.0 pKi = 10.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 10.0 pKi = 10.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 10.0 pKi = 10.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 10.0 pKi = 10.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 10.0 pKi = 10.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1349 8630 0 125I-Iodomelatonin 1 2 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 None
5311134 8630 0 125I-Iodomelatonin 1 2 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Mel 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Mel 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Mel 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Mel 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Mel 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Mel 1 9 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
198 7101 126 125I-Mel 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
82148 7101 126 125I-Mel 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
99 7101 126 125I-Mel 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
CHEMBL10878 7101 126 125I-Mel 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
DB06594 7101 126 125I-Mel 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1357 9263 139 125I-Mel 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Mel 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Mel 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Mel 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Mel 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Mel 1 9 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
198 7101 126 UNDEFINED 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
82148 7101 126 UNDEFINED 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
99 7101 126 UNDEFINED 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
CHEMBL10878 7101 126 UNDEFINED 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
DB06594 7101 126 UNDEFINED 1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
1354 10209 15 UNDEFINED 275 2 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N None
22133318 10209 15 UNDEFINED 275 2 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N None
CHEMBL490188 10209 15 UNDEFINED 275 2 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N None
12985495 188165 0 UNDEFINED 213 2 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 377 8 2 3 4.5 CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 None
CHEMBL476341 188165 0 UNDEFINED 213 2 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 377 8 2 3 4.5 CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
7922 8737 0 UNDEFINED 741 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO None
9798456 8737 0 UNDEFINED 741 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO None
CHEMBL476131 8737 0 UNDEFINED 741 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO None
9818487 180312 0 UNDEFINED 141 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 319 5 1 2 4.2 COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 None
CHEMBL453138 180312 0 UNDEFINED 141 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 319 5 1 2 4.2 COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 None
1357 9263 139 UNDEFINED 1 9 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 UNDEFINED 1 9 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 UNDEFINED 1 9 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 UNDEFINED 1 9 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 UNDEFINED 1 9 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 UNDEFINED 1 9 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
44579259 193893 0 UNDEFINED 331 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 347 6 1 3 4.0 COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL491604 193893 0 UNDEFINED 331 2 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 347 6 1 3 4.0 COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 None
1349 8630 0 125I-Iodomelatonin 1 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 None
5311134 8630 0 125I-Iodomelatonin 1 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
44579115 188614 0 UNDEFINED 162 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 348 6 2 3 4.2 CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
CHEMBL477835 188614 0 UNDEFINED 162 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 348 6 2 3 4.2 CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
12985494 197408 0 UNDEFINED 239 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 363 7 2 3 4.1 CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 None
CHEMBL518113 197408 0 UNDEFINED 239 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 363 7 2 3 4.1 CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 None
12985491 193759 0 UNDEFINED 91 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 411 6 1 2 5.1 COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL490595 193759 0 UNDEFINED 91 2 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 411 6 1 2 5.1 COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 None
44579260 193894 0 UNDEFINED 38 2 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 377 6 1 4 4.0 COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
CHEMBL491605 193894 0 UNDEFINED 38 2 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 377 6 1 4 4.0 COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
1357 9263 139 125I-Mel 1 9 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Mel 1 9 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Mel 1 9 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Mel 1 9 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Mel 1 9 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Mel 1 9 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
12985492 188610 0 UNDEFINED 177 2 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 459 6 1 2 5.1 COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL477833 188610 0 UNDEFINED 177 2 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 459 6 1 2 5.1 COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 None
44579163 188908 0 UNDEFINED 53 2 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 362 6 1 3 4.3 COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL478217 188908 0 UNDEFINED 53 2 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 362 6 1 3 4.3 COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 None
12985493 193871 0 UNDEFINED 213 2 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 363 7 1 3 4.3 COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
CHEMBL491403 193871 0 UNDEFINED 213 2 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 363 7 1 3 4.3 COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
1357 9263 139 125I-Mel 1 9 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Mel 1 9 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Mel 1 9 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Mel 1 9 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Mel 1 9 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Mel 1 9 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1358 6912 41 125I-Iodomelatonin 870 2 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 None
3976006 6912 41 125I-Iodomelatonin 870 2 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 None
CHEMBL285718 6912 41 125I-Iodomelatonin 870 2 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
12985489 197015 0 UNDEFINED 3 2 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 None
CHEMBL517502 197015 0 UNDEFINED 3 2 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 None
198 7101 126 None 1 6 Human 8.0 pKi = 8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
Drug Central 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
82148 7101 126 None 1 6 Human 8.0 pKi = 8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
Drug Central 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
99 7101 126 None 1 6 Human 8.0 pKi = 8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
Drug Central 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
CHEMBL10878 7101 126 None 1 6 Human 8.0 pKi = 8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
Drug Central 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
DB06594 7101 126 None 1 6 Human 8.0 pKi = 8 Binding
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting
Drug Central 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 None
122162 9166 75 125I-Iodomelatonin 18 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
1363 9166 75 125I-Iodomelatonin 18 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
CHEMBL286615 9166 75 125I-Iodomelatonin 18 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
1356 10061 99 None -3 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 None
208902 10061 99 None -3 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 None
2355 10061 99 None -3 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 None
CHEMBL1218 10061 99 None -3 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 None
DB00980 10061 99 None -3 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 None
5 6927 72 125I-Mel -23442 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-Mel -23442 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-Mel -23442 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-Mel -23442 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
107 6929 121 125I-Iodomelatonin -14791 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 125I-Iodomelatonin -14791 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 125I-Iodomelatonin -14791 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
4209 9937 75 125I-Mel -26915 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 125I-Mel -26915 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 125I-Mel -26915 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 125I-Mel -26915 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 125I-Mel -26915 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 125I-Mel -26915 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
122162 9166 75 125I-Iodomelatonin 18 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
1363 9166 75 125I-Iodomelatonin 18 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
CHEMBL286615 9166 75 125I-Iodomelatonin 18 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
70547 120120 79 125I-Iodomelatonin 10 2 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 202 3 2 1 1.8 CC(=O)NCCc1c[nH]c2ccccc12 None
CHEMBL33171 120120 79 125I-Iodomelatonin 10 2 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 202 3 2 1 1.8 CC(=O)NCCc1c[nH]c2ccccc12 None
122162 9166 75 125I-Iodomelatonin 18 2 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
1363 9166 75 125I-Iodomelatonin 18 2 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
CHEMBL286615 9166 75 125I-Iodomelatonin 18 2 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
903 119678 89 125I-Iodomelatonin -1 2 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 218 3 3 2 1.6 CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
CHEMBL33103 119678 89 125I-Iodomelatonin -1 2 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 218 3 3 2 1.6 CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
903 119678 89 125I-Iodomelatonin -1 2 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 218 3 3 2 1.6 CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
CHEMBL33103 119678 89 125I-Iodomelatonin -1 2 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 218 3 3 2 1.6 CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
1357 9263 139 125I-Iodomelatonin 1 9 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
12985490 187999 0 UNDEFINED 12 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 None
CHEMBL476132 187999 0 UNDEFINED 12 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 349 6 2 3 3.7 COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 None
122162 9166 75 125I-Iodomelatonin 18 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
1363 9166 75 125I-Iodomelatonin 18 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
CHEMBL286615 9166 75 125I-Iodomelatonin 18 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 None
10427851 188612 0 UNDEFINED 407 2 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 348 6 2 3 3.7 COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL477834 188612 0 UNDEFINED 407 2 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 348 6 2 3 3.7 COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 None
164157684 222881 0 125I-Iodomelatonin 60 2 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 1094 24 4 18 8.7 CC(C)(C)OC(=O)N(C)CC(CN(C)C(=O)OC(C)(C)C)CSP(=O)(O)O.CNCC(CNC)CSP(=O)(OCOC(=O)C1=CC=CC=C1)OCOC(=O)C2=CC=CC=C2.C1=CC=C(C=C1)C(=O)OCCl None
903 119678 89 125I-Iodomelatonin -1 2 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 218 3 3 2 1.6 CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
CHEMBL33103 119678 89 125I-Iodomelatonin -1 2 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 218 3 3 2 1.6 CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
44579261 193758 0 UNDEFINED 87 2 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 363 6 2 3 3.9 COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL490594 193758 0 UNDEFINED 87 2 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 363 6 2 3 3.9 COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 None
12985496 189110 0 UNDEFINED 31 2 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 389 7 2 3 4.5 COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 None
CHEMBL478438 189110 0 UNDEFINED 31 2 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 389 7 2 3 4.5 COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 None
681 8247 72 None -42 38 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 8247 72 None -42 38 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 8247 72 None -42 38 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 8247 72 None -42 38 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 8247 72 None -42 38 Human 8.3 pKi = 8.3 Binding
Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
1357 9263 139 125I-Iodomelatonin 1 9 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
1672 9263 139 125I-Iodomelatonin 1 9 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
224 9263 139 125I-Iodomelatonin 1 9 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
896 9263 139 125I-Iodomelatonin 1 9 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
CHEMBL45 9263 139 125I-Iodomelatonin 1 9 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
DB01065 9263 139 125I-Iodomelatonin 1 9 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 None
None 222878 0 125I-Mel 1 2 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 218 2 2 4 1.5 CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN None
70547 120120 79 125I-Iodomelatonin 10 2 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 202 3 2 1 1.8 CC(=O)NCCc1c[nH]c2ccccc12 None
CHEMBL33171 120120 79 125I-Iodomelatonin 10 2 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 202 3 2 1 1.8 CC(=O)NCCc1c[nH]c2ccccc12 None
44579296 193573 0 UNDEFINED 5 2 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 376 6 2 3 4.2 COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 None
CHEMBL489170 193573 0 UNDEFINED 5 2 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 376 6 2 3 4.2 COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 None
12835 222882 0 125I-Iodomelatonin 6 2 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 191 3 2 2 1.7 COC1=CC2=C(C=C1)NC=C2CCO None
44579164 188909 0 UNDEFINED 14 2 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 406 7 2 4 4.8 CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
CHEMBL478218 188909 0 UNDEFINED 14 2 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 406 7 2 4 4.8 CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 None
10220503 10528 0 None 2 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 None
4820 10528 0 None 2 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 None
7393 10528 0 None 2 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 None
CHEMBL2103822 10528 0 None 2 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 None
DB09071 10528 0 None 2 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 None
70547 120120 79 125I-Iodomelatonin 10 2 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 202 3 2 1 1.8 CC(=O)NCCc1c[nH]c2ccccc12 None
CHEMBL33171 120120 79 125I-Iodomelatonin 10 2 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 202 3 2 1 1.8 CC(=O)NCCc1c[nH]c2ccccc12 None
11196 8767 0 None 3 2 Human 5.5 pKi = 5.5 Binding
For ERK1/2 activation.For ERK1/2 activation.
Guide to Pharmacology 888 18 3 11 5.9 COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-] 28493341
154699456 8767 0 None 3 2 Human 5.5 pKi = 5.5 Binding
For ERK1/2 activation.For ERK1/2 activation.
Guide to Pharmacology 888 18 3 11 5.9 COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-] 28493341
115348 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 12764576
115348 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 2991499
115348 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9089668
115348 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9618428
1343 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 12764576
1343 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 2991499
1343 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9089668
1343 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9618428
CHEMBL289233 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 12764576
CHEMBL289233 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 2991499
CHEMBL289233 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9089668
CHEMBL289233 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9618428
DB08190 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 12764576
DB08190 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 2991499
DB08190 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9089668
DB08190 6858 47 None -4 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 358 4 2 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I 9618428
1356 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 15695169
1356 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 21182402
208902 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 15695169
208902 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 21182402
2355 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 15695169
2355 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 21182402
CHEMBL1218 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 15695169
CHEMBL1218 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 21182402
DB00980 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 15695169
DB00980 10061 99 None -3 2 Human 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 4 1 2 2.6 CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 21182402
198 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 12764576
198 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 9618428
82148 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 12764576
82148 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 9618428
99 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 12764576
99 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 9618428
CHEMBL10878 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 12764576
CHEMBL10878 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 9618428
DB06594 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 12764576
DB06594 7101 126 None 1 6 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 243 4 1 2 2.5 COc1ccc2c(c1)c(CCNC(=O)C)ccc2 9618428
10220503 10528 0 None 2 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 19054552
4820 10528 0 None 2 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 19054552
7393 10528 0 None 2 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 19054552
CHEMBL2103822 10528 0 None 2 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 19054552
DB09071 10528 0 None 2 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 4 1 2 2.3 CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 19054552
24749950 10688 8 None 588 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 284 6 1 3 3.0 COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C 18052314
7923 10688 8 None 588 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 284 6 1 3 3.0 COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C 18052314
CHEMBL394676 10688 8 None 588 2 Human 10.2 pKi = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 284 6 1 3 3.0 COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C 18052314
1350 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10420436
1350 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10737738
1350 8771 0 None -1 3 Mouse 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 24106342
4172142 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10420436
4172142 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10737738
4172142 8771 0 None -1 3 Mouse 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 24106342
CHEMBL10009 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10420436
CHEMBL10009 8771 0 None 1 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 10737738
CHEMBL10009 8771 0 None -1 3 Mouse 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 24106342
53238181 7721 0 None 741 2 Human 10.9 pKi = 10.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 21473625
7780 7721 0 None 741 2 Human 10.9 pKi = 10.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 21473625
CHEMBL1774519 7721 0 None 741 2 Human 10.9 pKi = 10.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 5 1 2 4.4 CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 21473625
57381997 8867 0 None - 1 Human 11.0 pKi = 11 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 7 1 2 4.1 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C 22301214
7781 8867 0 None - 1 Human 11.0 pKi = 11 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 7 1 2 4.1 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C 22301214
CHEMBL1946226 8867 0 None - 1 Human 11.0 pKi = 11 Binding
UnclassifiedUnclassified
Guide to Pharmacology 313 7 1 2 4.1 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C 22301214
121231413 10681 1 None 16982 2 Human 12.0 pKi = 12 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 6 1 3 3.5 CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC 26334942
9226 10681 1 None 16982 2 Human 12.0 pKi = 12 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 6 1 3 3.5 CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC 26334942
CHEMBL3612464 10681 1 None 16982 2 Human 12.0 pKi = 12 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 6 1 3 3.5 CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC 26334942
122162 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10696085
122162 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 12764576
122162 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 2843633
122162 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9089668
122162 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9737724
1363 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10696085
1363 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 12764576
1363 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 2843633
1363 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9089668
1363 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9737724
CHEMBL286615 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 10696085
CHEMBL286615 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 12764576
CHEMBL286615 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 2843633
CHEMBL286615 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9089668
CHEMBL286615 9166 75 None 18 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 292 5 2 1 3.4 CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9737724
3366 8192 40 None - 1 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 334 8 2 1 4.6 CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9840420
3467177 8192 40 None - 1 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 334 8 2 1 4.6 CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9840420
CHEMBL1327247 8192 40 None - 1 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 334 8 2 1 4.6 CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 9840420
7773 10687 0 None 12 2 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 3 2 2 2.6 COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1 15293992
86277838 10687 0 None 12 2 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 3 2 2 2.6 COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1 15293992
10428383 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 15943478
7783 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 15943478
CHEMBL33185 10685 5 None 151 2 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 6 1 3 4.4 CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC 15943478
1347 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 10696085
1347 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 2991499
1347 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 9089668
1864 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 10696085
1864 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 2991499
1864 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 9089668
CHEMBL127421 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 10696085
CHEMBL127421 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 2991499
CHEMBL127421 6950 56 None 1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O 9089668
12324 10683 0 None -2 2 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 591 13 3 4 7.0 O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 30126274
145966622 10683 0 None -2 2 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 591 13 3 4 7.0 O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 30126274
CHEMBL4210086 10683 0 None -2 2 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 591 13 3 4 7.0 O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 30126274
25210130 6857 0 None 91 2 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 19193160
7782 6857 0 None 91 2 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 19193160
CHEMBL514415 6857 0 None 91 2 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 363 6 2 3 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 19193160
11185529 10686 5 None 14 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 15293992
11185529 10686 5 None 14 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 17907131
7772 10686 5 None 14 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 15293992
7772 10686 5 None 14 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 17907131
CHEMBL189449 10686 5 None 14 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 15293992
CHEMBL189449 10686 5 None 14 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 3 1 2 3.1 COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 17907131
1358 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 12764576
1358 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 9089668
1358 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 9737724
3976006 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 12764576
3976006 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 9089668
3976006 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 9737724
CHEMBL285718 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 12764576
CHEMBL285718 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 9089668
CHEMBL285718 6912 41 None 870 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 279 3 1 1 3.7 CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 9737724
24750192 10689 13 None 1 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 222 5 1 3 1.3 COc1cccc(c1)N(CCNC(=O)C)C 18052314
7777 10689 13 None 1 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 222 5 1 3 1.3 COc1cccc(c1)N(CCNC(=O)C)C 18052314
CHEMBL237236 10689 13 None 1 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 222 5 1 3 1.3 COc1cccc(c1)N(CCNC(=O)C)C 18052314
1359 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10420436
1359 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10737738
5311198 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10420436
5311198 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10737738
CHEMBL274438 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10420436
CHEMBL274438 8951 21 None 125 2 Human 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 6 1 3 4.7 CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 10737738
24954989 8314 1 None -6 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 21568291
7774 8314 1 None -6 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 21568291
CHEMBL1802025 8314 1 None -6 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 273 4 1 4 1.5 CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 21568291
7922 8737 0 None 741 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 18778943
9798456 8737 0 None 741 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 18778943
CHEMBL476131 8737 0 None 741 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 349 6 2 3 3.7 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO 18778943
71508234 7492 0 None 38 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 23228808
7924 7492 0 None 38 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 23228808
CHEMBL2326202 7492 0 None 38 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 341 9 1 3 3.8 CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC 23228808
1346 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 12764576
1346 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 2991499
1346 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 9089668
1346 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 9618428
1858 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 12764576
1858 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 2991499
1858 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 9089668
1858 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 9618428
CHEMBL34730 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 12764576
CHEMBL34730 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 2991499
CHEMBL34730 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 9089668
CHEMBL34730 6948 47 None 25 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 266 4 2 2 2.5 COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl 9618428
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 12764576
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 2991499
1357 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 9089668
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 12764576
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 2991499
1672 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 9089668
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 12764576
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 2991499
224 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 9089668
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 12764576
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 2991499
896 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 9089668
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 12764576
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 2991499
CHEMBL45 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 9089668
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 12764576
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 2991499
DB01065 9263 139 None 1 9 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 232 4 2 2 1.9 COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 9089668
129776 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 9089668
1364 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 9089668
CHEMBL339105 6930 6 None 128 2 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 322 6 2 2 3.4 COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 9089668
1351 9174 21 None 1 2 Human 10.4 pKi None 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 280 4 2 2 3.1 COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C 15302228
219018 9174 21 None 1 2 Human 10.4 pKi None 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 280 4 2 2 3.1 COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C 15302228
CHEMBL4079759 9174 21 None 1 2 Human 10.4 pKi None 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 280 4 2 2 3.1 COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C 15302228
1362 10210 22 None -39 2 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 12764576
9870523 10210 22 None -39 2 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 12764576
CHEMBL429392 10210 22 None -39 2 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 498 12 2 4 5.2 CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 12764576
1355 10211 5 None -70 2 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 12764576
9806449 10211 5 None -70 2 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 12764576
CHEMBL14453 10211 5 None -70 2 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 13 2 4 5.6 CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 12764576
10849065 6925 8 None -4 2 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 262 6 3 3 1.2 OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 11068946
1345 6925 8 None -4 2 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 262 6 3 3 1.2 OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 11068946
CHEMBL126809 6925 8 None -4 2 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 262 6 3 3 1.2 OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 11068946
127856 10206 0 None 3 2 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 4 1 1 3.3 O=C(C1CCC1)NCCc1cccc2c1cccc2 12764576
1360 10206 0 None 3 2 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 4 1 1 3.3 O=C(C1CCC1)NCCc1cccc2c1cccc2 12764576
CHEMBL12296 10206 0 None 3 2 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 4 1 1 3.3 O=C(C1CCC1)NCCc1cccc2c1cccc2 12764576
1361 10207 0 None 1 2 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 4 1 2 3.1 CCc1ccc2c(c1)c(CCNC(=O)C)cs2 12764576
9816339 10207 0 None 1 2 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 4 1 2 3.1 CCc1ccc2c(c1)c(CCNC(=O)C)cs2 12764576
1348 8626 5 None 100 2 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 10205014
1348 8626 5 None 100 2 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 9089668
44208891 8626 5 None 100 2 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 10205014
44208891 8626 5 None 100 2 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 9089668
CHEMBL3260983 8626 5 None 100 2 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 10205014
CHEMBL3260983 8626 5 None 100 2 Human 8.9 pKi None 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 2 1 2 2.9 COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C 9089668
1354 10209 15 None 275 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 12764576
22133318 10209 15 None 275 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 12764576
CHEMBL490188 10209 15 None 275 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 334 5 2 3 3.8 COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N 12764576
1353 10208 5 None 112 2 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 12764576
9998187 10208 5 None 112 2 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 12764576
CHEMBL33549 10208 5 None 112 2 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 7 1 4 3.7 COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC 12764576
1349 8630 0 None 1 2 Human 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 10696085
1349 8630 0 None 1 2 Human 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 9618428
5311134 8630 0 None 1 2 Human 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 10696085
5311134 8630 0 None 1 2 Human 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 246 3 1 3 1.1 CC(=O)NCCN1CCc2c1c1CCOc1cc2 9618428