TAS2R42 (t2r42_human)

FAMILY

Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R42

GENE

TAS2R42 (TAS2R55)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 42, T2R42, Taste receptor type 2 member 55, T2R55

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
A
T
E
L
D
K
I
F
L
10
                   
I
L
A
I
A
E
F
I
I
S
20
                   
M
L
G
N
V
F
I
G
L
V
30
                   
N
C
S
E
G
I
K
N
Q
K
40
ICL1 TM2      
V
F
S
A
D
F
I
L
T
C
50
                   
L
A
I
S
T
I
G
Q
L
L
60
                   
V
I
L
F
D
S
F
L
V
G
70
    ECL1   TM3
L
A
S
H
L
Y
T
T
Y
R
80
                   
L
G
K
T
V
I
M
L
W
H
90
                   
M
T
N
H
L
T
T
W
L
A
100
                   
T
C
L
S
I
F
Y
F
F
K
110
    ICL2        
I
A
H
F
P
H
S
L
F
L
120
        TM4      
W
L
R
W
R
M
N
G
M
I
130
                   
V
M
L
L
I
L
S
L
F
L
140
                   
L
I
F
D
S
L
V
L
E
I
150
      ECL2      
F
I
D
I
S
L
N
I
I
D
160
                   
K
S
N
L
T
L
Y
L
D
E
170
                   
S
K
T
L
Y
D
K
L
S
I
180
TM5              
L
K
T
L
L
S
L
T
S
F
190
                   
I
P
F
S
L
F
L
T
S
L
200
                   
L
F
L
F
L
S
L
V
R
H
210
                   
T
R
N
L
K
L
S
S
L
G
220
ICL3 TM6      
S
R
D
S
S
T
E
A
H
R
230
                   
R
A
M
K
M
V
M
S
F
L
240
                   
F
L
F
I
V
H
F
F
S
L
250
                   
Q
V
A
N
W
I
F
F
M
L
260
ECL3 TM7      
W
N
N
K
C
I
K
F
V
M
270
                   
L
A
L
N
A
F
P
S
C
H
280
              H8  
S
F
I
L
I
L
G
N
S
K
290
                   
L
Q
Q
T
A
V
R
L
L
W
300
                   
H
L
R
N
Y
T
K
T
P
N
310
C-term
P
L
P
L

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K V ICL1ECL1 S H L Y T ECL1ICL2 H F P H S L F L W L R W ICL2ECL2 I S L N I I D K S N L T L Y L D E S K T L Y D K L S I ECL2ICL3 L G S R ICL3ECL3 L W N ECL3N-term M N-termC-term K T P N P L P L C-term A T E L D K I F L I L A I A E F I I S M L G N V F I G L V N C S E G I K N Q F S A D F I L T C L A I S T I G Q L L V I L F D S F L V G L A T Y R L G K T V I M L W H M T N H L T T W L A T C L S I F Y F F K I A R M N G M I V M L L I L S L F L L I F D S L V L E I F I D L K T L L S L T S F I P F S L F L T S L L F L F L S L V R H T R N L K L S S D S S T E A H R R A M K M V M S F L F L F I V H F F S L Q V A N W I F F M N K C I K F V M L A L N A F P S C H S F I L I L G N S K A V R L R N L Q Q T L L W H Y T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N G L M S I I F E A I A L I L F I K D 1 T C L A I S T I G Q L L V I L F D S F L 2 C T A L W T T L H N T M H W L M I V T K 3 I V M L L I L S L F L L I F D S L V L E 4 L S T L F L S F P I F S T L S L L T K L 5 V M S F L F L F I V H F F S L Q V A N W 6 F S H C S P F A N L A L M V F K I C K 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

t2r42_human inactive,

t2r42_human active

STRUCTURES

No structures available