MAS1 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

25IK

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

May 20, 2026

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 137 34x50 G.H5 K 232 G.H5.12
Polar TM2 N 64 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM2 N 64 2x37 G.H5 E 242 G.H5.22
Hydrophobic ICL2 R 141 34x54 G.H5 N 239 G.H5.19
Van-der-waals ICL2 R 141 34x54 G.H5 N 239 G.H5.19
Hydrophobic ICL2 I 138 34x51 G.S3 V 79 G.S3.01
Hydrophobic ICL2 I 138 34x51 G.H5 F 228 G.H5.08
Hydrophobic TM2 P 65 2x38 G.H5 E 242 G.H5.22
Polar TM3 S 133 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 N 239 G.H5.19
Polar C-term G 284 - G.H5 N 244 G.H5.24
Hydrophobic C-term G 284 - G.H5 N 244 G.H5.24
Van-der-waals C-term G 284 - G.H5 N 244 G.H5.24
Hydrophobic TM3 V 134 3x54 G.H5 L 245 G.H5.25
Polar ICL2 P 137 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 239 G.H5.19
Hydrophobic TM5 L 210 5x59 G.H5 L 245 G.H5.25
Van-der-waals TM5 L 210 5x59 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 235 G.H5.15
Polar TM7 F 281 7x54 G.H5 N 244 G.H5.24
Hydrophobic TM7 F 281 7x54 G.H5 N 244 G.H5.24
Van-der-waals TM7 F 281 7x54 G.H5 N 244 G.H5.24
Hydrophobic TM5 I 214 5x63 G.H5 L 245 G.H5.25
Hydrophobic TM3 V 134 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM3 V 134 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 V 134 3x54 G.H5 L 236 G.H5.16
Polar TM2 P 65 2x38 G.H5 Y 243 G.H5.23
Hydrophobic TM2 F 66 2x39 G.H5 N 244 G.H5.24
Polar ICL2 R 144 34x57 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 R 141 34x54 G.H5 I 235 G.H5.15
Van-der-waals ICL2 R 141 34x54 G.H5 I 235 G.H5.15
Aromatic TM2 F 66 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM2 F 66 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 138 34x51 G.H5 I 235 G.H5.15
Van-der-waals ICL2 I 138 34x51 G.H5 I 235 G.H5.15
Polar ICL2 Y 140 34x53 G.H5 Y 243 G.H5.23
Aromatic ICL2 Y 140 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 140 34x53 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 Y 140 34x53 G.H5 Y 243 G.H5.23
Polar ICL2 R 141 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 I 214 5x63 G.H5 L 240 G.H5.20
Van-der-waals TM5 I 214 5x63 G.H5 L 240 G.H5.20
Hydrophobic ICL2 C 142 34x55 G.S1 L 34 G.S1.02
Van-der-waals ICL2 C 142 34x55 G.S1 L 34 G.S1.02
Hydrophobic TM3 R 130 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 245 G.H5.25
Polar ICL2 R 144 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 144 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 137 34x50 G.H5 L 236 G.H5.16
Polar ICL2 Y 140 34x53 G.H5 E 242 G.H5.22
Hydrophobic ICL2 Y 140 34x53 G.H5 E 242 G.H5.22
Van-der-waals ICL2 Y 140 34x53 G.H5 E 242 G.H5.22
Hydrophobic ICL2 I 138 34x51 G.H5 K 232 G.H5.12
Van-der-waals ICL2 I 138 34x51 G.H5 K 232 G.H5.12
Polar ICL2 R 141 34x54 G.h2s4 T 104 G.h2s4.05
Polar ICL2 C 142 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 142 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 142 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 K 213 5x62 G.H5 L 236 G.H5.16
Van-der-waals TM5 K 213 5x62 G.H5 L 236 G.H5.16
Hydrophobic ICL2 R 141 34x54 G.H5 M 238 G.H5.18
Van-der-waals ICL2 R 141 34x54 G.H5 M 238 G.H5.18
Polar ICL2 C 142 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 C 142 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 C 142 34x55 G.hns1 R 31 G.hns1.02
Polar TM3 E 129 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 E 129 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM4 K 146 4x39 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 K 146 4x39 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 I 230 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 I 230 6x37 G.H5 L 245 G.H5.25
Polar TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 140 34x53 G.H5 N 239 G.H5.19
Van-der-waals ICL2 Y 140 34x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 S 133 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 H 143 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 143 34x56 G.hns1 R 32 G.hns1.03