MT1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

March 2, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

melatonin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 Y 207 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 125 3x50 G.H5 L 353 G.H5.25
Ionic TM5 R 218 5x69 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 218 5x69 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 240 6x37 G.H5 L 348 G.H5.20
Hydrophobic ICL2 D 136 34x54 G.HN E 28 G.HN.52
Hydrophobic TM5 I 210 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 221 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM5 V 214 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 214 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 129 3x54 G.H5 L 348 G.H5.20
Polar H8 N 301 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 301 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 F 244 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 129 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 129 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 217 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 221 5x72 G.H5 D 337 G.H5.09
Polar ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic H8 N 299 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 299 8x47 G.H5 G 352 G.H5.24
Ionic ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 217 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 217 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Polar H8 N 301 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 301 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Ionic TM5 R 218 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 218 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 222 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 222 - G.S6 Y 320 G.S6.02
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 213 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 210 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 214 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 221 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 129 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 M 240 6x37 G.H5 L 353 G.H5.25
Polar TM3 Y 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 129 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 129 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 217 5x68 G.H5 T 340 G.H5.12
Hydrophobic H8 Q 300 8x48 G.H5 G 352 G.H5.24
Polar TM3 Y 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Y 128 3x53 G.H5 N 347 G.H5.19