GAL1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WQ3

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41467-022-29072-3

PUBLICATION DATE

April 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

53 interactions (Click to see)

LIGANDS

galanin - Agonist pubchem gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem

PHYSIOLOGICAL LIGANDS

galanin-like peptide, galanin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 137 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 K 230 5x68 G.H5 I 344 G.H5.16
Polar TM6 T 248 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 E 308 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 308 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 231 5x69 G.H5 L 348 G.H5.20
Polar ICL2 R 141 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL3 N 233 - G.H5 D 341 G.H5.13
Hydrophobic TM5 L 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 227 5x65 G.H5 L 348 G.H5.20
Polar H8 N 309 8x49 G.H5 K 349 G.H5.21
Polar ICL2 S 143 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 137 3x54 G.H5 L 353 G.H5.25
Polar TM6 T 245 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 245 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 245 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 136 3x53 G.H5 C 351 G.H5.23
Polar TM6 K 236 6x24 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 K 236 6x24 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 K 236 6x24 G.h4s6 K 314 G.h4s6.08
Polar TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 236 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 237 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM2 T 70 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 237 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM5 L 231 5x69 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 237 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 S 140 34x50 G.H5 I 344 G.H5.16
Aromatic TM6 K 244 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 244 6x32 G.H5 F 354 G.H5.26
Van-der-waals H8 N 309 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 137 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 231 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 241 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 241 6x29 G.H5 F 354 G.H5.26
Polar TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 S 140 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 141 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 R 141 34x51 G.H5 F 336 G.H5.08
Hydrophobic H8 S 307 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 307 8x47 G.H5 G 352 G.H5.24
Polar TM6 T 248 6x36 G.H5 F 354 G.H5.26
Polar ICL2 S 140 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 140 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 140 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 227 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 133 3x50 G.H5 L 353 G.H5.25
Polar TM6 K 237 6x25 G.h4s6 T 316 G.h4s6.10