Y1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

May 18, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

pancreatic polypeptide, neuropeptide Y, peptide YY



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 P 145 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 145 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 145 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 145 - G.H5 I 344 G.H5.16
Hydrophobic TM6 M 264 6x36 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 146 - G.S3 L 194 G.S3.01
Ionic TM6 E 257 6x29 G.H5 K 345 G.H5.17
Polar TM6 E 257 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 257 6x29 G.H5 K 345 G.H5.17
Polar H8 N 326 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 326 8x49 G.H5 K 349 G.H5.21
Polar TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM7 L 323 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 L 323 7x56 G.H5 F 354 G.H5.26
Polar ICL2 R 146 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 R 146 - G.H5 T 340 G.H5.12
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic H8 N 324 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 324 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 261 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 261 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 Y 253 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 Y 253 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 347 G.H5.19
Polar TM2 N 73 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 73 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 I 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 141 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 N 324 8x47 G.H5 F 354 G.H5.26
Polar H8 K 325 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 K 325 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 K 325 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 W 148 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 W 148 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 146 - G.H5 I 343 G.H5.15
Van-der-waals TM6 E 257 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Hydrophobic H8 K 325 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 325 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 146 - G.H5 F 336 G.H5.08