GPR174 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XV3

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-023-36575-0

PUBLICATION DATE

Feb. 15, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid - Agonist pubchem

ENDOGENOUS LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 123 - G.H5 I 383 G.H5.15
Hydrophobic H8 F 299 8x50 G.H5 L 393 G.H5.25
Van-der-waals H8 F 299 8x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 124 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 124 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 126 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 F 126 - G.H5 Y 391 G.H5.23
Hydrophobic ICL3 M 218 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 M 218 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 Q 220 - G.h4s6 T 350 G.h4s6.03
Polar TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 H 127 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 C 129 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 120 3x54 G.H5 L 388 G.H5.20
Ionic ICL3 D 221 - G.H5 R 385 G.H5.17
Polar ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 D 221 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 L 222 - G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL4 T 296 - G.H5 L 393 G.H5.25
Polar TM6 K 225 6x30 G.H5 Q 384 G.H5.16
Polar TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 D 128 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 D 128 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 123 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 Y 216 - G.S6 Y 360 G.S6.02
Polar ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Polar H8 N 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 297 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 297 8x48 G.H5 E 392 G.H5.24
Polar H8 E 298 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM1 F 44 1x57 G.H5 L 393 G.H5.25
Hydrophobic ICL1 V 55 - G.H5 L 393 G.H5.25
Van-der-waals ICL1 V 55 - G.H5 L 393 G.H5.25
Hydrophobic TM3 I 112 3x46 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 124 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 124 - G.H5 F 376 G.H5.08
Hydrophobic TM2 M 58 2x43 G.H5 L 393 G.H5.25
Ionic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar TM6 K 225 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar ICL1 R 53 - G.H5 Y 391 G.H5.23
Hydrophobic ICL1 R 53 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 R 53 - G.H5 Y 391 G.H5.23
Aromatic ICL2 F 124 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 124 - G.S1 H 41 G.S1.02
Hydrophobic ICL4 Y 293 - G.H5 L 393 G.H5.25
Polar ICL2 F 126 - G.H5 H 387 G.H5.19
Aromatic ICL2 F 126 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 126 - G.H5 H 387 G.H5.19
Hydrophobic TM2 M 58 2x43 G.H5 L 394 G.H5.26
Ionic TM6 E 224 6x29 G.H5 R 385 G.H5.17
Polar TM6 E 224 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 224 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM3 R 116 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM1 Y 47 1x60 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 115 3x49 G.H5 L 394 G.H5.26
Hydrophobic H8 E 298 8x49 G.H5 L 393 G.H5.25
Hydrophobic TM3 F 119 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 F 119 3x53 G.H5 L 394 G.H5.26
Polar ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 124 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 F 119 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 F 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 228 6x33 G.H5 L 388 G.H5.20
Polar ICL3 Q 220 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 220 - G.S6 C 359 G.S6.01
Polar ICL3 L 222 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 M 218 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 F 124 - G.H5 C 379 G.H5.11
Polar ICL2 P 123 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 123 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 123 - G.H5 H 387 G.H5.19
Hydrophobic ICL4 T 296 - G.H5 E 392 G.H5.24