chemerin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7YKD

RESOLUTION

2.8 Å

REFERENCE

10.1073/PNAS.2214324120

PUBLICATION DATE

April 19, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

60 interactions (Click to see)

LIGANDS

chemerin C-terminal peptide - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

chemerin C-terminal peptide, chemerin, 18R-HEPE, resolvin E1, EPA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 P 258 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 252 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 252 - G.H5 K 345 G.H5.17
Hydrophobic TM7 M 319 7x56 G.H5 D 350 G.H5.22
Hydrophobic TM5 Y 240 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 257 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 257 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Q 148 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 252 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 252 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 145 34x51 G.S3 L 194 G.S3.01
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 243 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 252 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 252 - G.H5 F 354 G.H5.26
Hydrophobic ICL1 K 71 - G.HN R 24 G.HN.48
Van-der-waals ICL1 K 71 - G.HN R 24 G.HN.48
Hydrophobic TM6 I 261 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x36 G.H5 L 353 G.H5.25
Polar TM2 N 74 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 N 74 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 145 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM7 M 319 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 M 319 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Q 148 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM5 K 246 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 141 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 145 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM2 N 74 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 144 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 144 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM7 M 319 7x56 G.H5 K 349 G.H5.21
Van-der-waals TM7 M 319 7x56 G.H5 K 349 G.H5.21
Hydrophobic TM5 L 247 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 A 253 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 A 253 - G.H5 F 354 G.H5.26
Polar ICL2 N 149 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 149 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 149 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 Q 148 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 148 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 148 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Polar ICL2 R 151 34x57 G.hns1 R 32 G.hns1.03
Polar TM3 S 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 145 34x51 G.H5 T 340 G.H5.12
Polar ICL2 N 149 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 149 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 149 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 262 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 262 6x37 G.H5 L 353 G.H5.25
Polar TM6 K 257 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 257 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 P 258 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 258 6x33 G.H5 L 353 G.H5.25