NOP receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8F7X

RESOLUTION

3.3 Å

REFERENCE

10.1016/J.CELL.2022.12.026

PUBLICATION DATE

Dec. 14, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

58 interactions (Click to see)

LIGANDS

nociceptin/orphanin FQ - Agonist pubchem gtoplig chembl_ligand gtoplig pubchem pubchem

ENDOGENOUS LIGANDS

nociceptin/orphanin FQ



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 238 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 151 3x53 G.H5 C 351 G.H5.23
Polar TM3 A 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 245 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 247 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 R 162 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 162 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 162 - G.H5 C 351 G.H5.23
Hydrophobic TM6 I 261 6x33 G.H5 F 354 G.H5.26
Ionic ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL2 P 155 - G.H5 N 347 G.H5.19
Polar ICL2 R 162 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 156 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 156 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 155 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 155 - G.H5 I 344 G.H5.16
Ionic ICL2 D 160 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 160 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 160 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 247 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 155 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 155 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 248 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 248 - G.H5 F 354 G.H5.26
Van-der-waals H8 D 323 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 N 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 257 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 R 241 5x64 G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 247 - G.S6 Y 320 G.S6.02
Ionic TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Polar H8 N 325 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 242 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 159 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 246 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 246 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 247 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 247 - G.H5 D 341 G.H5.13
Hydrophobic TM6 I 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 353 G.H5.25