FFA4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8G59

RESOLUTION

2.6 Å

REFERENCE

10.1126/SCIENCE.ADD6220

PUBLICATION DATE

March 8, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

55 interactions (Click to see)

LIGANDS

TUG-891 - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

linoleic acid, oleic acid, α-linolenic acid, myristic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 140 3x54 G.H5 L 349 G.H5.16
Polar TM6 T 265 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 265 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 265 6x37 G.H5 L 358 G.H5.25
Polar C-term T 324 - G.H5 N 357 G.H5.24
Hydrophobic TM5 I 233 5x64 G.H5 L 349 G.H5.16
Hydrophobic ICL2 Q 144 - G.H5 I 348 G.H5.15
Hydrophobic TM5 L 241 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 254 6x26 G.H4 D 315 G.H4.17
Hydrophobic TM5 L 241 5x72 G.H5 A 342 G.H5.09
Van-der-waals TM5 L 241 5x72 G.H5 A 342 G.H5.09
Hydrophobic ICL3 A 246 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 A 246 - G.H5 F 339 G.H5.06
Hydrophobic TM3 I 140 3x54 G.H5 N 352 G.H5.19
Hydrophobic ICL3 L 245 - G.h4s6 F 323 G.h4s6.20
Hydrophobic ICL3 Y 247 - G.h4s6 E 318 G.h4s6.09
Polar TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Aromatic TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 L 262 6x34 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 143 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 L 143 - G.H5 K 345 G.H5.12
Hydrophobic TM6 L 262 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM5 R 240 5x71 G.H5 K 345 G.H5.12
Van-der-waals TM5 R 240 5x71 G.H5 K 345 G.H5.12
Polar ICL3 Y 247 - G.H5 D 346 G.H5.13
Hydrophobic TM6 L 266 6x38 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 140 3x54 G.H5 L 353 G.H5.20
Polar TM6 R 254 6x26 G.H4 K 314 G.H4.16
Hydrophobic TM6 R 254 6x26 G.H4 K 314 G.H4.16
Van-der-waals TM6 R 254 6x26 G.H4 K 314 G.H4.16
Polar TM6 H 251 6x23 G.h4s6 I 319 G.h4s6.10
Van-der-waals TM6 H 251 6x23 G.h4s6 I 319 G.h4s6.10
Polar TM3 C 139 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 C 139 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 C 139 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 Q 258 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 Q 258 6x30 G.H5 V 359 G.H5.26
Hydrophobic TM6 R 261 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 261 6x33 G.H5 V 359 G.H5.26
Polar TM3 H 142 3x56 G.HN R 32 G.HN.50
Aromatic TM3 H 142 3x56 G.HN R 32 G.HN.50
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.20
Hydrophobic TM6 L 262 6x34 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 262 6x34 G.H5 V 359 G.H5.26
Ionic TM5 R 238 5x69 G.H5 D 346 G.H5.13
Polar TM5 R 238 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM5 L 241 5x72 G.h4s6 Y 320 G.h4s6.11
Van-der-waals TM5 L 241 5x72 G.h4s6 Y 320 G.h4s6.11
Polar C-term M 323 - G.H5 N 357 G.H5.24
Van-der-waals C-term M 323 - G.H5 N 357 G.H5.24
Hydrophobic TM5 T 234 5x65 G.H5 L 349 G.H5.16
Van-der-waals TM5 T 234 5x65 G.H5 L 349 G.H5.16
Ionic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.09
Polar TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.09
Hydrophobic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.09
Van-der-waals TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.09
Polar TM5 S 237 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 S 237 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 I 230 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 I 230 5x61 G.H5 L 358 G.H5.25
Hydrophobic ICL2 Q 144 - G.H5 N 352 G.H5.19
Polar ICL3 Y 247 - G.h4s6 Y 320 G.h4s6.11
Hydrophobic ICL3 Y 247 - G.h4s6 Y 320 G.h4s6.11
Van-der-waals ICL3 Y 247 - G.h4s6 Y 320 G.h4s6.11
Hydrophobic TM5 S 237 5x68 G.H5 L 349 G.H5.16
Polar TM3 E 135 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 143 - G.H5 I 348 G.H5.15
Hydrophobic ICL3 A 246 - G.h4s6 Y 320 G.h4s6.11
Van-der-waals ICL3 A 246 - G.h4s6 Y 320 G.h4s6.11
Hydrophobic TM5 T 234 5x65 G.H5 L 353 G.H5.20
Polar TM5 R 238 5x69 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 238 5x69 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 238 5x69 G.H5 Q 350 G.H5.17
Hydrophobic TM3 R 136 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 140 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 I 140 3x54 G.H5 Y 356 G.H5.23