BB1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8H0P

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-022-00743-6

PUBLICATION DATE

Aug. 9, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

NMB30 - Agonist

ENDOGENOUS LIGANDS

gastrin-releasing peptide, neuromedin B, gastrin releasing peptide(14-27) (human), GRP-(18-27)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 145 3x54 G.H5 L 349 G.H5.16
Ionic TM6 R 261 6x30 G.H5 D 346 G.H5.14
Polar TM6 R 261 6x30 G.H5 D 346 G.H5.14
Hydrophobic TM6 R 261 6x30 G.H5 D 346 G.H5.14
Van-der-waals TM6 R 261 6x30 G.H5 D 346 G.H5.14
Hydrophobic TM3 A 144 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM7 L 324 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL1 P 78 - G.H5 E 355 G.H5.22
Hydrophobic ICL3 H 253 - G.H4 V 314 G.H4.16
Hydrophobic TM6 L 264 6x33 G.H5 L 353 G.H5.21
Hydrophobic TM6 R 261 6x30 G.H5 L 349 G.H5.16
Van-der-waals TM6 R 261 6x30 G.H5 L 349 G.H5.16
Hydrophobic ICL3 T 254 - G.S6 I 323 G.S6.01
Polar TM2 N 79 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 79 2x40 G.H5 N 357 G.H5.24
Polar H8 S 330 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 S 330 8x49 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 79 2x40 G.H5 E 355 G.H5.22
Hydrophobic ICL1 P 78 - G.H5 Y 356 G.H5.23
Van-der-waals ICL1 P 78 - G.H5 Y 356 G.H5.23
Hydrophobic H8 F 331 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 331 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 264 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 264 6x33 G.H5 L 358 G.H5.25
Polar TM6 R 261 6x30 G.H5 Q 350 G.H5.18
Van-der-waals TM6 R 261 6x30 G.H5 Q 350 G.H5.18
Hydrophobic ICL3 H 253 - G.S6 I 323 G.S6.01
Van-der-waals ICL3 H 253 - G.S6 I 323 G.S6.01
Polar TM6 Q 257 6x26 G.H5 Q 350 G.H5.18
Hydrophobic TM6 Q 257 6x26 G.H5 Q 350 G.H5.18
Van-der-waals TM6 Q 257 6x26 G.H5 Q 350 G.H5.18
Polar TM6 T 260 6x29 G.H5 V 359 G.H5.26
Aromatic ICL3 H 253 - G.S6 Y 325 G.S6.03
Hydrophobic ICL3 H 253 - G.S6 Y 325 G.S6.03
Van-der-waals ICL3 H 253 - G.S6 Y 325 G.S6.03
Hydrophobic ICL2 P 148 - G.H5 K 345 G.H5.12
Polar ICL3 H 253 - G.S6 C 324 G.S6.02
Hydrophobic ICL3 H 253 - G.S6 C 324 G.S6.02
Van-der-waals ICL3 H 253 - G.S6 C 324 G.S6.02
Hydrophobic TM3 I 145 3x54 G.H5 L 353 G.H5.21
Hydrophobic ICL2 M 149 - G.H5 C 344 G.H5.12
Hydrophobic TM3 I 145 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 358 G.H5.25
Polar ICL2 P 148 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 148 - G.H5 N 352 G.H5.19
Hydrophobic TM6 Q 257 6x26 G.S6 I 323 G.S6.01
Van-der-waals TM6 Q 257 6x26 G.S6 I 323 G.S6.01
Polar ICL4 S 328 - G.H5 N 357 G.H5.24
Hydrophobic ICL4 S 328 - G.H5 N 357 G.H5.24
Van-der-waals ICL4 S 328 - G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 149 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 M 149 - G.H5 K 345 G.H5.12
Hydrophobic ICL2 P 148 - G.H5 L 349 G.H5.16
Hydrophobic ICL2 M 151 - G.H5 Y 356 G.H5.23
Polar TM3 A 144 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM6 Q 257 6x26 G.H5 D 346 G.H5.14
Van-der-waals ICL2 M 151 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 M 151 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 M 151 - G.H5 N 352 G.H5.19
Hydrophobic TM7 L 327 7x56 G.H5 V 359 G.H5.26
Van-der-waals TM7 L 327 7x56 G.H5 V 359 G.H5.26
Hydrophobic ICL3 H 253 - G.S6 P 326 G.S6.04
Van-der-waals ICL3 H 253 - G.S6 P 326 G.S6.04
Hydrophobic ICL2 M 151 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 M 149 - G.S3 V 199 G.S3.02
Van-der-waals ICL2 M 149 - G.S3 V 199 G.S3.02
Hydrophobic ICL2 M 149 - G.S1 L 40 G.S1.02
Polar ICL3 H 253 - G.H4 R 310 G.H4.13
Hydrophobic ICL3 H 253 - G.H4 R 310 G.H4.13
Van-der-waals ICL3 H 253 - G.H4 R 310 G.H4.13
Hydrophobic ICL2 M 149 - G.H5 F 341 G.H5.09
Hydrophobic TM3 R 141 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 D 140 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 140 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 149 - G.H5 I 348 G.H5.15