FFA4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8H4K

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41422-023-00835-X

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

46 interactions (Click to see)

LIGANDS

GW9508 - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

linoleic acid, oleic acid, α-linolenic acid, myristic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 262 6x34 G.H5 L 393 G.H5.25
Polar TM5 S 237 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 S 237 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 S 237 5x68 G.H5 D 381 G.H5.13
Polar TM3 I 140 3x54 G.H5 N 387 G.H5.19
Hydrophobic TM3 I 140 3x54 G.H5 N 387 G.H5.19
Hydrophobic ICL3 Y 247 - G.h4s6 I 358 G.h4s6.20
Van-der-waals ICL3 Y 247 - G.h4s6 I 358 G.h4s6.20
Hydrophobic ICL2 G 146 - G.hns1 R 39 G.hns1.03
Hydrophobic TM6 R 254 6x26 G.h4s6 G 353 G.h4s6.09
Ionic TM5 R 240 5x71 G.H5 D 378 G.H5.10
Polar TM5 R 240 5x71 G.H5 D 378 G.H5.10
Van-der-waals TM5 R 240 5x71 G.H5 D 378 G.H5.10
Polar ICL3 A 246 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 R 145 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 140 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Q 144 - G.H5 I 383 G.H5.15
Polar TM5 R 238 5x69 G.H5 Q 385 G.H5.17
Hydrophobic ICL3 Y 247 - G.S6 P 361 G.S6.03
Hydrophobic TM5 L 245 5x76 G.S6 P 361 G.S6.03
Hydrophobic TM5 L 241 5x72 G.h4s6 I 358 G.h4s6.20
Hydrophobic ICL3 Y 247 - G.H4 V 346 G.H4.16
Polar TM3 C 139 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 C 139 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 143 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 143 - G.H5 N 387 G.H5.19
Van-der-waals ICL2 L 143 - G.H5 N 387 G.H5.19
Hydrophobic TM3 I 140 3x54 G.H5 L 384 G.H5.16
Hydrophobic TM5 I 233 5x64 G.H5 L 384 G.H5.16
Van-der-waals TM5 I 233 5x64 G.H5 L 384 G.H5.16
Hydrophobic ICL3 H 251 - G.H4 V 346 G.H4.16
Van-der-waals ICL3 H 251 - G.H4 V 346 G.H4.16
Polar ICL1 T 74 - G.H5 Y 391 G.H5.23
Hydrophobic ICL1 T 74 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 T 74 - G.H5 Y 391 G.H5.23
Polar TM3 C 139 3x53 G.H5 N 387 G.H5.19
Polar TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 245 5x76 G.S6 Y 360 G.S6.02
Van-der-waals TM5 L 245 5x76 G.S6 Y 360 G.S6.02
Ionic ICL3 H 251 - G.H4 D 347 G.H4.17
Polar ICL3 H 251 - G.H4 D 347 G.H4.17
Hydrophobic ICL3 H 251 - G.H4 D 347 G.H4.17
Van-der-waals ICL3 H 251 - G.H4 D 347 G.H4.17
Polar TM5 L 245 5x76 G.H4 R 342 G.H4.12
Polar ICL3 Y 247 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 Y 247 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Y 247 - G.S6 C 359 G.S6.01
Hydrophobic TM5 L 245 5x76 G.S6 H 362 G.S6.04
Van-der-waals TM5 L 245 5x76 G.S6 H 362 G.S6.04
Hydrophobic ICL2 Q 144 - G.H5 K 380 G.H5.12
Hydrophobic TM6 L 262 6x34 G.H5 L 388 G.H5.20
Hydrophobic TM5 T 234 5x65 G.H5 L 388 G.H5.20
Polar C-term T 324 - G.H5 N 392 G.H5.24
Hydrophobic C-term T 324 - G.H5 N 392 G.H5.24
Van-der-waals C-term T 324 - G.H5 N 392 G.H5.24
Hydrophobic TM5 L 241 5x72 G.S6 Y 360 G.S6.02
Hydrophobic ICL3 H 251 - G.H4 K 343 G.H4.13
Hydrophobic TM6 L 266 6x38 G.H5 L 393 G.H5.25