GPR21 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HIX

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41467-023-35882-W

PUBLICATION DATE

March 15, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 C 218 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 C 218 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 135 - G.H5 R 380 G.H5.12
Polar TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Van-der-waals TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Hydrophobic TM3 I 131 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 131 3x54 G.H5 Y 391 G.H5.23
Polar TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 F 232 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 F 232 - G.H4 R 347 G.H4.17
Polar ICL2 L 135 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 135 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 135 - G.S1 H 41 G.S1.02
Aromatic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 221 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 221 5x69 G.H5 L 388 G.H5.20
Hydrophobic ICL3 F 232 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 F 232 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 F 232 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 F 232 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 135 - G.S3 V 217 G.S3.01
Hydrophobic TM5 F 215 5x63 G.H5 L 393 G.H5.25
Hydrophobic TM5 R 228 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 R 228 5x76 G.h4s6 T 350 G.h4s6.03
Polar TM6 M 252 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM6 M 252 6x35 G.H5 Y 391 G.H5.23
Van-der-waals TM6 M 252 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM5 C 218 5x66 G.H5 L 393 G.H5.25
Van-der-waals TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 135 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 134 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 134 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 F 232 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 I 225 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 225 5x73 G.h4s6 Y 358 G.h4s6.20
Polar TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 135 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 135 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 131 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 R 231 5x79 G.hgh4 E 322 G.hgh4.12
Van-der-waals TM5 R 231 5x79 G.hgh4 E 322 G.hgh4.12
Polar TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 135 - G.H5 C 379 G.H5.11
Polar TM5 R 228 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 228 5x76 G.S6 C 359 G.S6.01
Hydrophobic TM5 I 217 5x65 G.H5 Q 384 G.H5.16
Ionic TM5 D 224 5x72 G.H5 R 385 G.H5.17
Polar TM5 D 224 5x72 G.H5 R 385 G.H5.17
Ionic TM5 H 221 5x69 G.H5 D 381 G.H5.13
Polar TM5 H 221 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 228 5x76 G.S6 P 361 G.S6.03
Hydrophobic ICL2 P 134 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 131 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 136 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 136 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 135 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 135 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 P 134 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 134 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 N 138 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 M 252 6x35 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 252 6x35 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 217 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 R 228 5x76 G.H4 L 346 G.H4.16
Hydrophobic TM5 I 214 5x62 G.H5 Y 391 G.H5.23