D3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IRT

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41422-023-00808-0

PUBLICATION DATE

June 7, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

58 interactions (Click to see)

LIGANDS

rotigotine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

ENDOGENOUS LIGANDS

dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 R 222 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 222 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 222 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 222 5x72 G.H5 D 341 G.H5.13
Polar ICL2 Q 139 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 139 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 139 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 R 323 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 323 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 136 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 136 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 Y 138 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 138 - G.H5 N 347 G.H5.19
Hydrophobic TM4 Q 144 4x36 G.HN E 28 G.HN.52
Hydrophobic TM3 A 131 3x53 G.H5 C 351 G.H5.23
Ionic TM6 E 324 6x30 G.H5 K 345 G.H5.17
Polar TM6 E 324 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 E 324 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 324 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM3 V 132 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 132 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 R 222 5x72 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 222 5x72 G.H5 K 345 G.H5.17
Polar TM3 R 128 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 128 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM2 T 64 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 64 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 64 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 K 326 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 326 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 135 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 135 - G.H5 I 343 G.H5.15
Van-der-waals TM6 M 330 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 135 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 135 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 H 140 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 140 - G.hns1 A 31 G.hns1.02
Polar TM5 R 218 5x68 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 222 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM3 V 132 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 132 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM6 K 326 6x32 G.H5 G 352 G.H5.24
Ionic TM5 R 222 5x72 G.h4s6 E 318 G.h4s6.12
Ionic TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 Y 138 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 138 - G.H5 D 350 G.H5.22
Polar TM6 A 327 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 327 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 327 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 330 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 330 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 N 387 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 387 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Q 139 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 139 - G.hns1 R 32 G.hns1.03
Polar ICL2 Q 139 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 139 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Q 139 - G.H5 N 347 G.H5.19
Hydrophobic TM6 E 324 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 324 6x30 G.H5 F 354 G.H5.26
Polar H8 N 387 8x47 G.H5 K 349 G.H5.21
Hydrophobic ICL2 Q 139 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 139 - G.H5 I 343 G.H5.15
Hydrophobic TM6 K 326 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 326 6x32 G.H5 L 353 G.H5.25
Polar TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 131 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 211 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 215 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 215 5x65 G.H5 L 348 G.H5.20
Polar ICL2 Y 138 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 138 - G.H5 C 351 G.H5.23
Polar ICL2 G 141 - G.H5 D 350 G.H5.22
Polar ICL2 P 135 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 135 - G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 128 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 135 - G.H5 T 340 G.H5.12