TAAR9 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

May 31, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

SPERMIDINE - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 138 - G.H5 I 383 G.H5.15
Polar TM3 T 135 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 T 135 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 138 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 138 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 Y 140 - G.H5 H 387 G.H5.19
Hydrophobic TM5 I 220 5x61 G.H5 L 393 G.H5.25
Polar TM3 T 135 3x55 G.H5 Q 384 G.H5.16
Hydrophobic TM6 T 259 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 259 6x36 G.H5 L 393 G.H5.25
Polar TM6 K 255 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 255 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 255 6x32 G.H5 L 394 G.H5.26
Hydrophobic H8 Y 315 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 137 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 228 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 Q 227 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM6 A 256 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 138 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 376 G.H5.08
Polar TM3 A 133 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 137 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 137 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 141 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 141 - G.hns1 R 38 G.hns1.02
Polar TM5 Q 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 227 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 231 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 231 5x72 G.H5 R 385 G.H5.17
Ionic TM5 K 230 5x71 G.H5 D 381 G.H5.13
Polar TM5 K 230 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM5 V 223 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 223 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 224 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 137 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 137 - G.H5 R 380 G.H5.12
Polar TM5 Q 227 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 227 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 227 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 260 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 260 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 138 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 138 - G.S1 H 41 G.S1.02
Polar TM3 V 134 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 134 3x54 G.H5 Q 384 G.H5.16
Aromatic TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Polar TM5 Q 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 227 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 227 5x68 G.H5 L 388 G.H5.20
Ionic TM6 K 255 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 255 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 134 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 V 134 3x54 G.H5 Y 391 G.H5.23
Hydrophobic H8 W 317 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 W 317 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM5 I 231 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 252 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 252 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 T 142 - G.hns1 A 39 G.hns1.03
Polar TM6 T 259 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 259 6x36 G.H5 E 392 G.H5.24