CXCR3 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8K2X

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41421-023-00617-0

PUBLICATION DATE

Nov. 29, 2023

3D VIEW

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LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

C-X-C motif chemokine 10 - Agonist

PHYSIOLOGICAL LIGANDS

CCL11, CXCL10, CXCL12α, CXCL11, CCL5, CCL19, CCL20, CCL13, CXCL9, CCL7



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 256 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 153 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 253 6x33 G.H5 L 348 G.H5.20
Polar H8 G 322 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 322 8x47 G.H5 G 352 G.H5.24
Polar TM3 N 152 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 N 152 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 N 152 3x53 G.H5 N 347 G.H5.19
Polar ICL2 G 163 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 163 34x57 G.hns1 R 32 G.hns1.03
Ionic TM6 R 249 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 G 247 - G.H5 K 345 G.H5.17
Van-der-waals H8 K 324 8x49 G.H5 K 349 G.H5.21
Polar TM2 S 86 2x37 G.H5 D 350 G.H5.22
Polar TM2 T 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 88 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 160 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 153 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 153 3x54 G.H5 L 348 G.H5.20
Polar TM6 R 249 6x29 G.h4s6 T 316 G.h4s6.10
Polar ICL2 T 157 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 165 - G.HN E 28 G.HN.52
Van-der-waals ICL2 P 165 - G.HN E 28 G.HN.52
Polar TM3 R 149 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 149 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 160 34x54 G.hns1 R 32 G.hns1.03
Polar ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 Y 160 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 R 252 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 149 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 160 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM3 I 153 3x54 G.H5 C 351 G.H5.23
Polar H8 V 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 V 323 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 V 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 161 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL2 A 156 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 249 6x29 G.H5 L 348 G.H5.20
Ionic H8 K 324 8x49 G.H5 D 350 G.H5.22
Polar H8 K 324 8x49 G.H5 D 350 G.H5.22
Polar TM5 S 245 5x68 G.H5 D 341 G.H5.13
Aromatic TM6 R 249 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 249 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 249 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 157 34x51 G.H5 F 336 G.H5.08
Polar ICL3 Q 248 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 Q 248 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 Q 248 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 Y 160 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 Y 160 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 Y 160 34x54 G.S1 E 33 G.S1.01
Polar ICL3 R 246 - G.H5 K 345 G.H5.17
Hydrophobic TM5 L 242 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 242 5x65 G.H5 L 348 G.H5.20
Ionic ICL2 R 161 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 161 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 161 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 R 249 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 249 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 257 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 156 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 157 34x51 G.S3 L 194 G.S3.01
Hydrophobic H8 V 323 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 Y 160 34x54 G.H5 I 343 G.H5.15