5-HT2A receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8UWL

RESOLUTION

2.8 Å

REFERENCE

10.1126/SCIENCE.ADN6354

PUBLICATION DATE

May 29, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

lisuride - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine, tryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 180 34x50 G.H5 L 236 G.H5.16
Hydrophobic ICL2 P 180 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 180 34x50 G.H5 I 235 G.H5.15
Polar ICL2 S 184 34x54 G.hns1 R 31 G.hns1.02
Polar TM2 N 107 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM2 N 107 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM3 R 173 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 181 34x51 G.S3 V 79 G.S3.01
Hydrophobic TM6 L 325 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 325 6x37 G.H5 L 245 G.H5.25
Hydrophobic TM6 A 321 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 A 321 6x33 G.H5 L 240 G.H5.20
Polar TM7 Y 380 7x53 G.H5 N 244 G.H5.24
Van-der-waals ICL4 F 383 - G.H5 N 244 G.H5.24
Hydrophobic TM6 K 320 6x32 G.H5 V 246 G.H5.26
Hydrophobic TM6 M 312 6x24 G.S6 Y 212 G.S6.02
Hydrophobic TM3 I 177 3x54 G.H5 L 236 G.H5.16
Polar TM6 S 314 6x26 G.H5 Q 237 G.H5.17
Hydrophobic TM6 S 314 6x26 G.H5 Q 237 G.H5.17
Hydrophobic TM6 Q 313 6x25 G.h4s6 I 210 G.h4s6.20
Hydrophobic ICL4 N 384 - G.H5 N 244 G.H5.24
Van-der-waals ICL4 N 384 - G.H5 N 244 G.H5.24
Polar TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Polar ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 N 317 6x29 G.H5 V 246 G.H5.26
Van-der-waals TM6 N 317 6x29 G.H5 V 246 G.H5.26
Polar ICL2 P 180 34x50 G.H5 N 239 G.H5.19
Polar ICL2 R 185 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 185 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 185 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 173 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM2 T 109 2x39 G.H5 Y 243 G.H5.23
Polar TM2 T 109 2x39 G.H5 E 242 G.H5.22
Polar ICL2 H 183 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 H 183 34x53 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 H 183 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 181 34x51 G.H5 I 235 G.H5.15
Van-der-waals ICL2 I 181 34x51 G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 180 34x50 G.H5 K 232 G.H5.12
Polar ICL2 R 185 34x55 G.s2s3 K 78 G.s2s3.02
Hydrophobic ICL2 I 181 34x51 G.H5 F 228 G.H5.08
Hydrophobic TM6 V 324 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM3 A 176 3x53 G.H5 Y 243 G.H5.23
Polar TM6 N 317 6x29 G.H5 Q 237 G.H5.17
Van-der-waals TM6 N 317 6x29 G.H5 Q 237 G.H5.17
Hydrophobic TM6 A 321 6x33 G.H5 V 246 G.H5.26