MC3 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8W8Y

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

March 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

64 interactions (Click to see)

LIGANDS

γ-MSH (Human) - Agonist pubchem gtoplig uniprot uniprot uniprot pubchem

PHYSIOLOGICAL LIGANDS

ACTH (Human), ACTH (Mouse), β-MSH (Human), α-MSH (Human), β-MSH (Mouse), γ-MSH (Human), β-MSH (Rat), agouti-related protein (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 151 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 151 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 146 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 F 211 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM2 M 73 2x39 G.H5 Q 390 G.H5.22
Polar TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 - G.S3 V 217 G.S3.01
Polar TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 217 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM6 I 244 6x37 G.H5 L 393 G.H5.25
Polar TM3 T 145 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 150 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 150 - G.H5 I 383 G.H5.15
Hydrophobic TM4 T 157 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 157 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM6 K 239 6x32 G.H5 E 392 G.H5.24
Polar ICL2 H 153 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 153 - G.hns1 R 38 G.hns1.02
Polar TM6 K 239 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 217 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL3 L 224 - G.H4 L 346 G.H4.16
Polar TM3 T 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 T 243 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 214 5x65 G.H5 L 388 G.H5.20
Ionic TM7 R 302 7x56 G.H5 E 392 G.H5.24
Polar TM7 R 302 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 302 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 302 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 F 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 F 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 G 240 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 218 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 V 218 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 F 213 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 H 153 - G.hns1 A 39 G.hns1.03
Polar ICL2 R 151 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 A 149 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 149 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 150 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic TM5 M 210 5x61 G.H5 L 393 G.H5.25
Polar ICL2 H 153 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 H 153 - G.HN Q 35 G.HN.52
Hydrophobic TM5 I 221 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 221 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 214 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 214 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 150 - G.H5 R 380 G.H5.12
Hydrophobic TM5 A 214 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 214 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 217 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 R 220 5x71 G.H5 R 385 G.H5.17
Ionic TM5 R 220 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 220 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 220 5x71 G.H5 D 381 G.H5.13
Polar TM6 T 243 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 243 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 243 6x36 G.H5 E 392 G.H5.24
Polar TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 149 - G.H5 Q 384 G.H5.16
Polar ICL1 H 70 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 H 70 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 150 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 150 - G.H5 F 376 G.H5.08