kisspeptin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XGU

RESOLUTION

3.0 Å

REFERENCE

10.1126/SCIADV.ADN7771

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

81 interactions (Click to see)

LIGANDS

TAK448 - Agonist

PHYSIOLOGICAL LIGANDS

kisspeptin-10, kisspeptin-54, kisspeptin-52, kisspeptin-14, kisspeptin-13



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 261 6x33 G.H5 L 348 G.H5.20
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 148 - G.H5 I 343 G.H5.15
Polar TM3 V 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 148 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 148 - G.H5 F 336 G.H5.08
Hydrophobic ICL1 M 73 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 M 73 - G.H5 D 350 G.H5.22
Ionic H8 H 329 8x49 G.H5 D 350 G.H5.22
Polar H8 H 329 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 H 329 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 257 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Polar ICL2 L 151 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 147 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 147 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 148 - G.H5 T 340 G.H5.12
Hydrophobic TM3 V 143 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 T 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 T 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 257 6x29 G.H5 F 354 G.H5.26
Hydrophobic H8 G 327 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 151 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 147 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 147 - G.H5 I 344 G.H5.16
Polar TM2 T 77 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 152 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 152 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 148 - G.S3 L 194 G.S3.01
Hydrophobic TM5 M 227 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 227 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 151 - G.S3 L 194 G.S3.01
Polar H8 H 329 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 H 329 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 H 329 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM5 L 231 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 231 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM7 L 326 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 326 7x56 G.H5 G 352 G.H5.24