OPN1SW - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

June 11, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

all-trans-retinal - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar H8 K 308 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 243 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 223 5x61 G.H5 L 353 G.H5.25
Polar TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 C 351 G.H5.23
Polar TM6 S 237 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 237 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 237 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 A 226 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 136 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 136 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 Q 234 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 234 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 234 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 Q 234 5x72 G.S6 Y 320 G.S6.02
Polar TM6 T 240 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 240 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 T 240 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM2 L 69 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 L 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 243 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 243 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 136 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 247 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 239 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 L 227 5x65 G.H5 I 344 G.H5.16
Polar TM6 T 239 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 239 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM3 V 135 3x53 G.H5 C 351 G.H5.23
Polar H8 Q 309 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM2 L 69 2x39 G.H5 C 351 G.H5.23
Polar TM6 T 240 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 T 240 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 T 240 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 M 250 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 E 246 6x32 G.H5 F 354 G.H5.26
Polar TM3 V 135 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 135 3x53 G.H5 N 347 G.H5.19
Polar ICL2 R 144 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 144 - G.hns1 A 31 G.hns1.02
Polar TM6 A 238 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 A 238 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 K 138 3x56 G.H5 I 343 G.H5.15
Van-der-waals TM3 K 138 3x56 G.H5 I 343 G.H5.15
Hydrophobic TM5 V 230 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 230 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 230 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 136 3x54 G.H5 L 348 G.H5.20
Polar TM6 T 239 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 T 239 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 T 239 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 254 6x40 G.H5 L 353 G.H5.25
Polar H8 N 307 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 223 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 N 142 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 142 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 V 247 6x33 G.H5 L 353 G.H5.25
Polar H8 K 308 8x48 G.H5 L 353 G.H5.25
Polar TM6 S 237 6x23 G.H5 K 345 G.H5.17
Hydrophobic H8 K 308 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 308 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 230 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 K 242 6x28 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 242 6x28 G.H5 F 354 G.H5.26
Polar H8 N 307 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 307 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 307 8x47 G.H5 G 352 G.H5.24
Polar TM5 Q 233 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 Q 233 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 136 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 247 6x33 G.H5 L 348 G.H5.20